Programme Overview Level 1, Zeus Hall

Thursday May 20, 2010 8:00-18:30 Registrations

19:30 Official Opening Ceremony – Welcome Reception 5th International Hydrocephalus Workshop & 24th Annual Hellenic Congress of Neurosurgery

Friday May 21, 20107:45-8:00 Welcome and Announcements Harold L. Rekate, President of the 5th International Hydrocephalus Workshop Konstantinos Kouzelis, Vice President of the 5th International Hydrocephalus Workshop and President of the Hellenic Neurosurgical Society

Session I Definition and classification Moderators Carsten Wikkelso, President ISHCSF Petra Klinge, President-Elect ISHCSF

8:00-8:30 The definition and classification of hydrocephalus: A consensus statement from the Hydrocephalus Classification Study Group Harold L. Rekate MD

8:30-9:00 Treatment of hydrocephalus based on the new classification Spyros Sgouros MD FRCS(SN)

9:00-9:30 Clinical research in hydrocephalus Where are we now and where are we going? John Kestle MD

9:30-10:00 International study of infant hydrocephalus Shunts vs. ETV Shlomi Constantini MD MSc

10:00-10:30 Coffee with exhibitors

Session II Pediatric hydrocephalus Moderators Shlomi Constantini, Thomas Brinker

17

10:30-12:00 Oral presentations

12:00-13:00 Poster discussions

13:00-14:00 Lunch and poster viewing

Session III Special session: The importance of Dr. Anthony Marmarou Moderators Harold L. Rekate, President of the 5th International Hydrocephalus Workshop Konstantinos Kouzelis, Vice-President of the 5th International Hydrocephalus Workshop and President of the Hellenic Neurosurgical Society

14:00-14:30 Modeling of CSF dynamics and cerebral blood flow Marek Czosnyka PhD

14:30-15:00 The practice guidelines for the diagnosis and management of NPH History and perspectives Petra Klinge MD PhD

15:00-15:15 The NPH program at Medical College of Virginia: Patient Selection Gunes Aygok MD PhD

15:15-15:30 The NPH program at Medical College of Virginia: Surgical management Harold F. Young MD

15:30-16:00 Break with exhibitors

Session IV Engineering aspects Moderators Michael Pollay, Panagiotis Selviaridis 16:00-17:10 Oral presentations

17:10-18:10 Poster presentations

20:00 Cretan night (optional – please consult the Workshop Secretariat)

Programme Overview

Saturday May 22, 2010

Session V The basic science of hydrocephalus Moderators John Kestle, Vasilios Varsos

08:00 – 10:00 Oral presentations

10:00-10:30 Break with exhibitors

Session VI Physiology and neuroimaging Moderators Jogi Pattisapu, Spyros Sgouros

10:30-11:00 Overview of the dual CSF outflow system Michael Pollay MD PhD

11:00-11:30 Cranial pulsatility: Physiologically important or just a passing wave Mark Luciano MD PhD

11:30-12:00 Disproportionately enlarged subarachnoid-space hydrocephalus Matsasune Ishikawa MD PhD

12:00-12:30 Neuro-imaging of hydrocephalus What’s missing from the picture? Norman Relkin MD PhD

12:30-13:30 Lunch and poster viewing

Level 0, Minos Hall

Session VII Clinical studies Moderators Michael Kiefer, Alexander Andreou

13:30-14:00 Ethical considerations in hydrocephalus research in children and adults Michael Williams MD

14:00-14:30 Alzheimer disease, systemic hypertension and congenital factors What are their roles in normal pressure hydrocephalus? Neil Graff-Radford MD

14:30-15:00 Adjustable valves in the treatment of INPH Carsten Wikkelso MD PhD

15:00-15:30 Lessons learned and questions raised during 20 years of ETV Andre Grotenhuis MD

15:30-16:00 Break with exhibitors

Session VIII Neuroendoscopy Moderators Martin Schuhmann, George Stratzalis

16:00-18:00 Oral presentations

20:30 Gala dinner

Sunday May 23, 2010

Session IX NPH and diagnosis Moderators Michael Pollay, Marek Czosnyka

09:00 – 10:30 Oral presentations

10:30 – 10:50 Break with exhibitors

Session X NPH and shunts Moderators Mark Luciano, Konstantinos Polyzoidis

10:50-13:00 Oral presentations

13:00-13:30 Summary of the accomplishments of the meeting Harold L. Rekate, Kostantinos Kouzelis, Michael Pollay

Programme Overview

Final Programme Level 1, Zeus Hall

Thursday May 20, 2010 8:00-18:30 Registrations

19:30 Official Opening Ceremony – Welcome Reception 5th International Hydrocephalus Workshop & 24th Annual Hellenic Congress of Neurosurgery

Friday May 21, 20107:45-8:00 Welcome and Announcements Harold L. Rekate, President of the 5th International Hydrocephalus Workshop Konstantinos Kouzelis, Vice President of the 5th International Hydrocephalus Workshop and President of the Hellenic Neurosurgical Society

Session I Definition and classification Moderators Carsten Wikkelso, President ISHCSF Petra Klinge, President-Elect ISHCSF

8:00-8:30 The definition and classification of hydrocephalus: A consensus statement from the Hydrocephalus Classification Study Group Harold L. Rekate MD

8:30-9:00 Treatment of hydrocephalus based on the new classification Spyros Sgouros MD FRCS(SN)

9:00-9:30 Clinical research in hydrocephalus Where are we now and where are we going? John Kestle MD

9:30-10:00 International study of infant hydrocephalus Shunts vs. ETV Shlomi Constantini MD MSc

10:00-10:30 Coffee with exhibitors

Session II Pediatric hydrocephalus Moderators Shlomi Constantini, Thomas Brinker

10:30-12:00 Oral presentations

o01. QuAlITy AND SAFETy oF HoME ICP MoNITorINg CoMPArEDTo IN-HoSPITAl MoNITorINgAndresen M., Juhler M., Munch T.Clinic of Neurosurgery, Copenhagen University Hospital, Denmarko02. PATHoPHySIology oF BrAIN STEM lESIoNS DuE To oVErDrAINAgEAntes S., Eymann R., Schmitt M., Kiefer M.Saarland University, Medical School, Department of Neurosurgery, Homburg-Saar, Germanyo03. INAPProPrIATEly loW-PrESSurE (NEgATIVE-PrESSurE) HyDroCEPHAluS: EXPErIENCE WITH 20 PATIENTSHamilton Μ., MDCM, FRCSCDepartment of Clinical Neurosciences, Division of Neurosurgery, University of Calgary, Canadao04. ADulTS TrEATED For INFANTIlE HyDroCEPHAluS – A VEry loNg TErMFolloW-uP STuDyPersson E.K. MD PhD, Lindquist B. PhD, Fernell E. MD PhD, Uvebrant P. MD PhDInstitute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Swedeno05. MEDICATIoN oVEruSE AS A CAuSE oF CHroNIC HEADACHE IN SHuNTED HyDroCEPHAluS PATIENTSJuhler M., Willer L., Jensen R.H.Department of Neurosurgery, Rigshospitalet, Denmark The Headache Research Centre, Glostrup Hospital, Denmarko06. TrEATMENT oF PrEMATurE CHIlDrEN WITH PoSTHEMorrHAgIC HyDroCEPHAluSBy TEMPorAry METHoDS oF ICP NorMAlISATIoNZinenko D., Vladimirov M., Hafizov F.Moscow Pediatric and Children Surgery Research Institute, Russiao07. SHuNT SurgEry CAN BE AVoIDED IN MoST PATIENTS WITH BENIgN INTrACrANIAl CySTSHögfeldt M.1, Tisell M.1, Hellström P.2, Edsbagge M.2, Wikkelsö C.2

(1) Department of Neurosurgery, Sahlgrenska University Hospital Gothenburg, Sweden(2) Department of Neurology, Sahlgrenska University Hospital Gothenburg, Swedeno08. ASyMPToMATIC TrEATMENT FAIlurE IN PEDIATrIC HyDroCEPHAluS- FEATurES oF AN uNDEr-DIAgNoSED (?) ENTITySchuhmann M. U.1, Speil A.2, Haas-Lude K.2, Alber M.2, Bevot A.2

(1) Section of Pediatric Neurosurgery, Department of Neurosurgery, Eberhard Karls University Hospital, Tuebingen, Germany(2) Department of Pediatric Neurology, Eberhard Karls University Children‘s Hospital, Tuebingen, Germanyo09. THE MANAgEMENT AND THE ouTCoME oF INTrAVENTrICulAr HEMorrHAgE IN BABIES WITH loW BIrTH WEIgHTInagaki T.1, Kawamoto K.2, Kinoshita Y.3

(1) Pediatric Neurosurgery, Kansai Medical University, Japan(2) Neurosurgery, Kansai Medical University, Japan(3) Pediatrics, Kansai Medical University, Japan

12:00-13:00 Poster discussions

Final Programme

Associated disorders

P01. PoSTCrANIECToMy HyDroCEPHAluSVenetikidis A., Paleologos T.S., Markellos A., Papanikolaou P.G., Stamatiou S., Voidonikolas L., Georgoulis G., Damilakis K., Kiriakou T.Department of Neurosurgery, General Hospital Nikaia-Piraeus, GreeceP02. PoST-TrAuMATIC HyDroCEPHAluS IN SEVErE HEAD INJury - SErIES oF 9 CASESSyrmos N.1, Iliadis Ch.1, Barkatsa V.1, Valadakis V.1, Grigoriou K.1, Gavridakis G.2, Arvanitakis D.1

(1) Department of Neurosurgery, Venizeleio General Hospital, Heraklion, Crete, Greece(2) CT Scan Department, Venizeleio General Hospital, Heraklion, Crete, GreeceP03. lHErMITTE-DuCloS DISEASE PrESENTINg WITH HyDroCEPHAluS: CASE rEPorT AND lITErATurE rEVIEW Choong Hyun Kim MD PhD, Jin Hwan Cheong MD PhD, Jae Min Kim MD PhDDepartment of Neurosurgery, Hanyang University, Guri, Korea

Discussion

Complications

P04. rArE ABDoMINAl CoMPlICATIoNS oF VENTrICulo-PErIToNEAl (VP) SHuNTSPaidakakos N., Rokas E., Theodoropoulos S., Dimogerontas G., Rovlias A., Makrigiannakis G., Papadopoulos M., Konstantinidis E.Department of Neurosurgery, Asclepeion General Hospital of Voula, Athens, GreeceP05. INFECTIoNS AFTEr CErEBroSPINAl FluID SHuNT IN ElDErly PATIENTSSyrmos N.1, Iliadis Ch.1 , Barkatsa V.1, Valadakis V.1, Grigoriou K.1, Gavridakis G.2, Arvanitakis D.1

(1) Department of Neurosurgery, Venizeleio General Hospital, Heraklion, Crete, Greece(2) CT Scan Department, Venizeleio General Hospital, Heraklion, Crete, GreeceP06. VENTrICuloATrIAl SHuNTS: PrEDICTorS oF FAIlurESBatra S., Solomon D., Moghekar A., Blitz A., Rigamonti D.The Departments of Neurology and Neurosurgery, Johns Hopkins University School of Medicine,Baltimore, USAP07. ENDoSCoPIC BrAIN-WASHINg oN TrEATMENT oF VENTrICulAr INFECTIoNQing Xiao, Guo-qiang Chen, Jia-ping Zheng, Jin-ting Wu, Hui Liang, Huan-cong ZuoDepartment of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing, China

Discussion

Associated disorders

P08. A 40-yEAr SErIES WITH 1070 SyrINX- AND CHIArI-PATIENTS Aschoff A.1, Akbar M.2, Wiedenhöfer B.2, Muhcu S.1, Orakcioglu B.1, Geletneky C.1

(1) Department of Neurosurgery, University of Heidelberg, Germany(2) Department of Orthopaedics, University of Heidelberg, Germany

P09. EXPrESSIoN ANAlySIS oF HIgH MoBIlITy grouP BoX-1 ProTEIN (HMgB-1) IN THE CErEBrAl CorTEX, HyPPoCAMPuS, CErEBElluM oF THE CoNgENITAl HyDroCEPHAluS rAT (H-TX)Mitsuya Watanabe MD, Masakazu Miyajima MD, Madoka Nakajima MD, Hajime Arai MD, Ikuko Ogino, Sinji Nakamura, Miyuki KunichikaDepartment of Neurosurgery, Juntendo University, Bunkyoku, Tokyo, JapanP10. ATyPICAl MENINgIoMA IN THE PoSTErIor FoSSA ASSoCIATED WITH ColPoCEPHAly AND CorPuS CAllouS AgENESISChoong Hyun Kim MD PhD, Jin Hwan Cheong MD PhD, Jae Min Kim MD PhDDepartment of Neurosurgery, Hanyang University, Guri, Korea

Potpourri

P11. EFFECT oF ANTIBIoTIC IMPrEgNATED SHuNTS oN INFECTIoN rATE IN ADulT HyDroCEPHAluS: A SINglE INSTITuTIoN’S EXPErIENCEHarrison Farber S., Parker S.L., Adogwa O., McGirt M.J., Solomon D., Rigamonti D.The Departments of Neurology and Neurosurgery, Johns Hopkins University School of Medicine,Baltimore, USAP12. THE oBSTruCTIVE NATurE oF PEDIATrIC HyDroCEPHAluS - rESulTS oF A HIgH-rESoluTIoN MrI STuDySchuhmann M.U.1, Filip Z.1, Ries B.G.2, Tatagiba M.S.1, Nägele T.1

(1) Section of Pediatric Neurosurgery, Department of Neurosurgery, Eberhard Karls University Hospital, Tuebingen, Germany(2) Department of Neuroradiology, Eberhard Karls University Hospital, Tuebingen, GermanyP13. SHuNT rElATED oCCluSIVE EXTErNAl HyDroCEPHAluSZinenko D.Moscow Pediatric and Children Surgery Research Institute, Russia Discussion

13:00-14:00 Lunch and poster viewing

Session III Special session: The importance of Dr. Anthony Marmarou Moderators Harold L. Rekate, President of the 5th International Hydrocephalus Workshop Konstantinos Kouzelis, Vice President of the 5th International Hydrocephalus Workshop and President of the Hellenic Neurosurgical Society

14:00-14:30 Modeling of CSF dynamics and cerebral blood flow Marek Czosnyka PhD

14:30-15:00 The practice guidelines for the diagnosis and management of NPH History and perspectives Petra Klinge MD PhD

15:00-15:15 The NPH program at Medical College of Virginia: Patient Selection Gunes Aygok MD PhD

Final Programme

15:15-15:30 The NPH program at Medical College of Virginia: Surgical management Harold F. Young MD

15:30-16:00 Break with exhibitors

Session IV Engineering aspects Moderators Michael Pollay, Panagiotis Selviaridis 16:00-17:10 Oral presentations

o10. SloW VASogENIC FluCTuATIoNS oF INTrACrANIAl PrESSurE AND CErEBrAl NEAr INFrArED SPECTroSCoPy – AN oBSErVATIoNAl STuDyCzosnyka Z.1, Weerakkody R. A.1, Czosnyka M.1, Balédent O.2, Souraya Stoquart El-sankari2, Pickard J.1

(1) Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (2) Department of Medical Physics and Imaging, University of Amiens Hospital, Amiens, France(3) Department of Neurology, Cliniques Universitaires Saint-Luc, Brussels, Belgiumo11. WHo NEEDS A SHuNT? CSF DyNAMICS PErSPECTIVECzosnyka M.1, Schuhmann M.2, Werrakody R.1, Keong N.2, Santarius T.1, Schmidt EA.4, Balédent O.1, Pickard JD.1, Czosnyka Z.1

(1) Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK

(2) Department of Neurosurgery, University of Tuebingen, Germany(3) Department of Medical Physics and Imaging, University of Amiens Hospital, France(4) Neurosurgery, Hopital Pourpan, Toulouse, Franceo12. SIMulATIoN oF SHuNT VAlVES IN A HyDroCEPHAluS MoDElKrause I.1, Walter M.1, Kiefer M.2, Leonhardt S.1

(1) Chair for Medical Information Technology, Helmholtz-Institute, RWTH Aachen, Germany (2) Neurosurgery, Saarland University, Medical School, Homburg-Saar, Germanyo13. rEAlISTIC PHANToM oF CrANIo-SPINAl HyDroDyNAMICSBouzerar R.1, Czosnyka M.2, Czosnyka Z.2, Balédent O.1

(1) Department of Medical Physics and Imaging, University of Amiens Hospital, Amiens, France(2) Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK o14. CSF DyNAMIC ProFIlE oF PoTENTIAl SHuNT CANDIDATES IN CoMPArISoNWITH HEAlTHy ElDErlyFrankel J. MSc1, Eklund A. PhD1,2, Malm J. MD PhD3

(1) Department of Biomedical Engineering, Umeå University Hospital, Sweden(2) Department of Radiation Sciences, Umeå University, Sweden (3) Department of Clinical Neuroscience, Umeå University, Swedeno15. ESTIMATIoN oF ouTFloW rESISTANCE – MoDEl DEPENDENCyEklund A. PhD1,2, Andersson K. MSc2, Malm J. MD PhD3

(1) Department of Biomedical Engineering, Umeå University Hospital, Sweden(2) Department of Radiation Sciences, Umeå University, Sweden(3) Department of Clinical Neuroscience, Umeå University, Sweden

o16. ENDoSCoPIC IIIrD VENTrICuloSToMy (ETV). SurgICAl TECHNIQuE AND PITFAllSBouramas D.1,2, Paidakakos N.2, Sotiriou F.1, Kouzounias K.1, Sklavounou M.2, Gekas N.1

(1) Department of Neurosurgery, Athens Naval Hospital, Greece(2) Department of Neurosurgery, Athens Bioclinic, Greece

17:10-18:10 Poster presentations

Engineering aspects 1

P14. ICMPluS SoFTWArE uSED For ASSESSMENT oF CSF DyNAMICSCzosnyka Z., Czosnyka M., Pickard J.D., Smielewski P.Department of Clinical Neurosciences, University of Cambridge, Cambridge, UKP15. ProgrAMMABlE SHuNT ASSISTANT TESTED IN CAMBrIDgE SHuNT EVAluATIoN lABorAToryCzosnyka M., Czosnyka Z.Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK P16. FAST FourIEr TrANSForMATIoN (FFT) For ICP SloW WAVES DETECTIoN Kiefer M.1, Schmitt M.1, Antes S.1, Krause I.2, Eymann R.1

(1) Department of Neurosurgery, Medical School, Saarland University, Homburg-Saar, Germany(2) Philips Chair for Medical Information Technology, Helmholtz-Institut, Aachen, GermanyP17. EXAMINATIoN oF DEPoSITS IN CSF SHuNT VAlVES uSINg SCANNINg ElECTroN MICroSCoPyCharalambides C., Sgouros S.Department of Neurosurgery, “Attikon” University Hospital, University of Athens, Greece

Discussion

Engineering aspects 2

P18. ICP ANAlySIS IN NPH: CoMPArISoN oF TIME-DoMAIN DErIVED VErSuS FrEQuENCy-DoMAIN DErIVED PulSE WAVE AMPlITuDE AND rElATED PArAMETErSSchuhmann M.U.1, Buddhakoralage S.1, Speil A.1, Helm J.2, Jaeger M.2, Eide P.3

(1) Section of Pediatric Neurosurgery, Department of Neurosurgery, Eberhard Karls University Hospital, Tuebingen, Germany (2) Department of Neurosurgery, University of Leipzig, Leipzig, Germany (3) Department of Neurosurgery, Rikshospitalet, Oslo University Hospital, Oslo, NorwayP19. AN INNoVATIVE PErMANENTly IMPlANTED WIrElESS INTrACrANIAl PrESSurE MoNITor uSINg MEMS TECHNology AND MICroWAVE TElEMETry For THE DIAgNoSIS oF HyDroCEPHAluSKralick F.A.1, Kawoos U.2, Warty R.3, Tofighi M.R.4, Rosen A.2

(1) Department of Neurosurgery, Hahnemann University Hospital, Philadelphia, USA (2) Department of Biomedical Engineering, Drexel University, Philadelphia, USA (3) Department of Electrical Engineering, Philadelphia, USA (4) Penn State University, the Capital College, Middletown, USA

Final Programme

P20. MICroSTruCTurAl AlTErATIoNS oF SIlICoNE CATHETErS IN AN ANIMAl EXPErIMENT: HISToPATHology AND SEM-FINDINgSEymann R.1, Kim Y.J.2, Bohle R.M.2, Kiefer M.1

(1) Department of Neurosurgery, Medical School, Saarland University, Homburg-Saar, Germany(2) Department of Pathology, Medical School, Saarland University, Homburg-Saar, Germany

Discussion

Selecting the right shunt

P21. WHAT IS THE APProPrIATE SHuNT SySTEM For NorMAl PrESSurE HyDroCEPHAluS?Chrissicopoulos C.¹, Mourgela S.¹, Kirgiannis K.¹, Petritsis K.¹, Ampertos N.¹, Sakellaropoulos A.², Spanos A.¹(¹) “Agios Savvas” Anticancer Institute, Department of Neurosurgery, Athens, Greece(2) “Neon Athineon” Hospital, Pulmonary and Critical Care Medicine, Athens, GreeceP22. SurgICAl MANAgEMENT oF ADulT CHroNIC HyDroCEPHAluS By uSINg VENTrICulo-PErIToNEAl SHuNTS WITH ADJuSTABlE VAlVES Paidakakos N., Rokas E., Theodoropoulos S., Dimogerontas G., Makrigiannakis G., Rovlias A.,Papadopoulos M., Konstantinidis E.Department of Neurosurgery, Asclepeion General Hospital of Voula, Athens, GreeceP23. ADJuSTABlE grAVITATIoNAl VAlVES – TECHNICAl oVErkIll or NECESSITy?Aschoff A.1, Kiefer M.2, Kehler U.3, Jung C.1, Dictus C.1

(1) Department of Neurosurgery, University of Heidelberg, Germany(2) Department of Neurosurgery University of Homburg/S, Germany(3) Department of Neurosurgery, Asklepios Klinik Hamburg-Altona, Germany

Discussion

Neuroendoscopy

P24. ADulT ENDoSCoPIC THIrD VENTrICuloSToMy IN oBSTruCTIVE HyDroCEPHAluSWoodworth G.F., See A., Batra S., Jallo G.I., Solomon D., Rigamonti D.Departments of Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USAP25. EFFICACy AND SAFETy oF THE 2MICroN CoNTINuouS WAVE lASEr IN NEuro-ENDoSCoPIC ProCEDurESSchuhmann M.U., Nagel C., Ebner F.E., Tatagiba M.S.Section of Pediatric Neurosurgery, Department of Neurosurgery, Eberhard Karls University Hospital, Tuebingen, Germany P26. BENIgN CErEBrAl AQuEDuCT STENoSIS IN AN ADulTChrissicopoulos C.¹, Mourgela S.¹, Ampertos N.¹, Sakellaropoulos A.², Kirgiannis K.¹, Petritsis K.¹, Spanos A.¹(1) “Agios Savvas” Anticancer Institute, Department of Neurosurgery, Athens, Greece(2) “Neon Athineon” Hospital, Pulmonary and Critical Care Medicine, Athens, Greece

Discussion

20:00 Cretan night (optional – please consult the Workshop Secretariat)

Saturday May 22, 2010

Session V The basic science of hydrocephalus Moderators John Kestle, Vasilios Varsos

08:00 – 10:00 Oral presentations

Ο17. CHANgES oF FrACTIoNAl ANISoTroPy (FA) AND APPArENT DIFFuSIoN CoEFFICIENT (ADC) IN PATIENTS WITH IDIoPATHIC NorMAl PrESSurE HyDroCEPHAluSMase M.1, Demura K.1, Osawa T.1, HattoriI M.2, KasaiI H.3, Miyati T.4, Yamada K.1

(1) Department of Neurosurgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan(2) Department of Neurology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan(3) Department of Radiology, Nagoya City University Hospital, Nagoya, Japan(4) Faculty of Health Science, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japano18. Mr-ElASTogrAPHy IN NorMAl PrESSurE HyDroCEPHAluS PrE- AND PoSTSHuNT – EVAluATIoN oF A NEW IN-VIVo METHoD AND IMPlICATIoNS For PATHogENESISSprung C.1, Freimann F.B.1, Streitberger K.J.2, Wiener E.3, Sack I.2

(1) Department of Neurosurgery, Charité - University Berlin, Campus Rudolf Virchow, Berlin, Germany(2) Department of Radiology, Charité - University Medicine Berlin, Campus Charité Mitte, Berlin, Germany(3) Department of Neuroradiology, Charité - University Medicine Berlin, Campus Charité Mitte, Berlin, Germany o19. NEW EPENDyMAl CEllS ArE BorN PoSTNATAlly AND SuPPorT VENTrICuloMEgAly IN HyDroCEPHAlIC MICEBátiz L.F.1, Jiménez A.J.2, Toledo C.D.1, Guerra M.1, Vio K.1, Rodríguez-Pérez L.M.2, Páez P.2,Pérez-Fígares J.M.2, Rodríguez E.M.1 (1) Instituto de Anatomía, Histología y Patología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile(2) Departamento de Biología Celular, Genética y Fisiología, Facultad de Ciencias, Universidad de Málaga, Málaga, Spaino20. gENE EXPrESSIoN ProFIlINg oF CHoroID PlEXuS IN AlZHEIMEr’S DISEASE rEVEAl IMPorTANT IMPlICATIoNS For CSF DyNAMICSStopa E.G.1, Nikonova E.V.2, Tanis K.Q.2, Podtelezhnikov A.A.2, Finney E.M.2, Stone D.J.2, Camargo L.M.2, Parker L.2, Verma A.2, Baird A.3, 4, Miller M.C.1, Donahue J.E.1, Gonzalez A.M.4, Eliceiri B.3, Silverberg G.D.1, Klinge P.M.1, Johanson C.E.1

(1) Departments of Neurosurgery and Pathology (Neuropathology Division), Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence, RI, USA(2) Molecular Profiling & Research Informatics, Merck Sharp & Dohme, West Point, PA, USA(3) Department of Surgery, University of California San Diego Medical Center, San Diego, CA, USA(4) School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, UK

Final Programme

o21. HyDroCEPHAluS AND AQuAPorINS. THE rolE oF AQuAPorIN-1Kalani MYS, Filippidis A.S., Rekate H.L. Division of Pediatric Neurosurgery, Barrow Neurological Institute, Phoenix, AZo22. HyDroCEPHAluS AND AQuAPorINS. THE rolE oF AQuAPorIN-4Filippidis A.S., Kalani MYS, Rekate H.L. Division of Pediatric Neurosurgery, Barrow Neurological Institute, Phoenix, AZo23. EXPErIMENTAl HyDroCEPHAluS INDuCES CHANgES IN CoNSTITuTIVE AQuAPorIN-4 EXPrESSIoN AND CHANgES MorPHology oF AQuAPorIN-4 PoSITIVE EPENDyMASkjolding A.D.1, Rowland I.2, Soegaard L.V.2, Praetorius J.3, Penkowa M.4, Juhler M.1

(1) University Clinic of Neurosurgery, Rigshospitalet, Copenhagen, Denmark(2) Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark(3) The Water and Salt Research Center, Department of Anatomy, Aarhus University, Aarhus, Denmark(4) Section of Neuroprotection, Department of Neuroscience and Pharmacology, Faculty of Health Science, Copenhagen University, Copenhagen, Denmarko24. PrENATAl MolECulAr DIAgNoSIS AND STEM CEll rESEArCH IN SEVErE TyPE oF l1CAM SyNDroME (X-lINkED HyDroCEPHAluS)Yamasaki M. MD PhD1,2, Nonaka M. MD PhD2, Shofuda T. MS1, Kanemura Y. MD PhD1,2

(1) Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Japan(2) Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, Japano25. EFFECT oF ACETAZolAMIDE oN AQuAPorIN-1 EXPrESSIoN oF CulTurED CHoroID PlEXuS CEllSPouya Ameli, Meenu Madan, Srinu Chigurupati, Amin Yu, Sic L. Chan, Jogi V. Pattisapu Hydrocephalus Research Laboratory, University of Central Florida College of Medicine o26. EXPErIENCE WITH FroNTo-TEMPorAl DEMENTIA IN PATIENTS SHuNTED For HyDroCEPHAluSWilliams M.A., Wilson R.K., Smith C.A.Sandra and Malcolm Berman Brain & Spine Institute, Adult Hydrocephalus Center, Sinai Hospital of Baltimore, Baltimore, MD USAo27. DIFFuSIoN TENSor IMAgINg EXPoSES FurTHEr lESIoNS To WHITE MATTEr IN INPHLenfeldt N. E.P. PhD MSc1,5, Larsson A. PhD2, Nyberg L. PhD2,3, Birgander R. MD PhD2, Eklund A. PhD2,4,5, Malm J. MD PhD1

(1) Department of Clinical Neuroscience, Umeå University, Sweden(2) Department of Radiation Sciences, Umeå University, Sweden(3) Department of Integrative Medical Biology, Umeå University, Sweden(4) Department of Biomedical Engineering and Informatics, Umeå University, Sweden(5) Centre for Biomedical Engineering and Physics, Umeå University, Swedeno28. QuANTITATIVE EVAluATIoN oF CSF CIrCulATIoN AT THE AQuEDuCT oF SylVIuSIN 3T Mr uNITKapsalaki E.1, Tsougos I.2, Theodorou K.2, Paterakis K.N.3, Fountas K.N.3

(1) Department of Diagnostic Radiology, University Hospital of Larisa, School of Medicine, University of Thessaly, Larisa, Greece(2) Department of Medical Physics, University Hospital of Larisa, School of Medicine, University of Thessaly, Larisa, Greece(3) Department of Neurosurgery, University Hospital of Larisa, School of Medicine, University of Thessaly, Larisa, Greece

10:00-10:30 Break with exhibitors

Session VI Physiology and neuroimaging Moderators Jogi Pattisapu, Spyros Sgouros

10:30-11:00 Overview of the dual CSF outflow system Michael Pollay MD PhD

11:00-11:30 Cranial pulsatility: Physiologically important or just a passing wave Mark Luciano MD PhD

11:30-12:00 Disproportionately enlarged subarachnoid-space hydrocephalus Matsasune Ishikawa MD PhD

12:00-12:30 Neuro-imaging of hydrocephalus What’s missing from the picture? Norman Relkin MD PhD

12:30-13:30 Lunch and poster viewing

Level 0, Minos Hall

Session VII Clinical studies Moderators Michael Kiefer, Alexander Andreou

13:30-14:00 Ethical considerations in hydrocephalus research in children and adults Michael Williams MD

14:00-14:30 Alzheimer disease, systemic hypertension and congenital factors What are their roles in normal pressure hydrocephalus? Neil Graff-Radford MD

14:30-15:00 Adjustable valves in the treatment of INPH Carsten Wikkelso MD PhD

15:00-15:30 Lessons learned and questions raised during 20 years of ETV Andre Grotenhuis MD

15:30-16:00 Break with exhibitors

Session VIII Neuroendoscopy Moderators Martin Schuhmann, George Stratzalis

16:00-18:00 Oral presentations

Final Programme

o29. ENDoSCoPIC FourTH VENTrICuloSToMy oN TrEATMENT oF FourTH VENTrIClE oBSTruCTIVE HyDroCEPHAluSGuo-qiang Chen, Qing Xiao, Jia-ping Zheng, Jin-ting Wu, Hui Liang, Huan-cong ZuoDepartment of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing, Chinao30. A ProSPECTIVE, rANDoMISED, CoNTrollED TrIAl To EVAluATE THE EFFICACy AND SAFETy oF ENDoSCoPIC CHoroID PlEXuS CoAgulATIoN WITH THIrD VENTrICuloSToMy IN THE TrEATMENT oF IDIoPATHIC NorMAl PrESSurE HyDroCEPHAluS (ISrCTN29863839)Edwards R.J., Aquilina K., Bunnage M., Pople I.K.Department of Neurosurgery, Frenchay Hospital, Bristol, UKo31. NorMAl PrESSurE HyDroCEPHAluS (NPH): INDICATIoNS For ENDoSCoPIC THIrD VENTrICuloSToMy (ETV)Paidakakos N., Borgarello S., Naddeo M.Department of Neurosurgery, C.T.O. Hospital, Turin, Italyo32. CoMPlICATIoNS oF ENDoSCoPIC THIrD VENTrICuloSCoPy. A META-ANAlySISBouras T., Sgouros S.Department of Neurosurgery, “Attikon” University Hospital, University of Athens, Greeceo33. THE rolE oF ENDoSCoPIC THIrD VENTrICuloSToMy IN THE TrEATMENT oF SElECTED PATIENTS WITH NorMAl PrESSurE HyDroCEPHAluS Fountas K.N. MD PhD1, Kapsalaki E.Z. MD PhD2, Paterakis K.N. MD PhD1, Lee G.P. PhD3,Hadjigeorgiou G. MD PhD4

(1) Department of Neurosurgery, University Hospital of Larisa, University of Thessaly, School of Medicine, Larisa, Greece(2) Department of Diagnostic Radiology University Hospital of Larisa, University of Thessaly, School of Medicine, Larisa, Greece(3) Department of Neurology, Medical College of Georgia, Augusta, GA, USA(4) Department of Neurology, University Hospital of Larisa, University of Thessaly, School of Medicine, Larisa, Greeceo34. THE rolE oF ArTIFICIAl CErEBroSPINAl FluID AS PErFuSATE IN NEuroENDoSCoPIC SurgEry-BASIC INVESTIgATIoN-Masakazu Miyajima, Misuya Watanabe, Madoka Nakajima, Ikuko Ogino, Hajime AraiDepartment of Neurosurgery, Juntendo University, Tokyo, Japano35. A TWElVE-yEAr HoSPITAl ouTCoME oN PATIENTS WITH IDIoPATHIC HyDroCEPHAluSStranjalis G.1,2, Kalamatianos T.1,2, Koutsarnakis C.1,2, Loufardaki M.1,2, Stavrinou L.1,2, Sakas D.E.1,2

(1) Department of Neurosurgery, University of Athens, Athens, Greece(2) HCNR “Professor Petros S. Kokkalis”, Athens, Greece o36. INTrACrANIAl PrESSurE ANAlySIS IN PATIENTS WITH CHIArI 1 MAlForMATIoN Radek Frič, Per Kristian EideDepartment of Neurosurgery, Rikshospitalet, Oslo University Hospital, Norwayo37. A 22-yEAr-SErIES oF 1042 PATIENTS WITH 1271 ADJuSTABlE VAlVESDictus C., Biedermann N., Piotrowicz A., Unterberg A., Vienenkoetter B., Schiebel P., Hertle D., Haux D., Jung C., Aschoff A.Department of Neurosurgery, University of Heidelberg, Germanyo38. THE IDIoPATHIC ADulT’S HyDroCEPHAluS. A HISTorICAl rESEArCHMissori P.1, Paolini S.2, Currà A.1

(1) Department of Neuroscience, Neurology and Neurosurgery, University of Rome “Sapienza”, Italy(2) University of Perugia, Neurosurgery, IRCCS “Neuromed” Pozzilli, Italy

o39. DyNAMICS oF CSF FloW IN SlIT VENTrIClE SyNDroMEEymann R.1, Schmitt M.1, Antes S.1, Shamdeen M.G., Kiefer M.(1) Department of Neurosurgery, Medical School, Saarland University, Homburg-Saar, Germany(2) Department of Pediatrics, Medical School, Saarland University, Homburg-Saar, Germany

20:30 Gala dinner

Sunday May 23, 2010

Session IX NPH and diagnosis Moderators Michael Pollay, Marek Czosnyka

09:00 – 10:30 Oral presentations

o40. IDIoPATHIC NorMAl PrESSurE HyDroCEPHAluS (INPH) IN A DEFINED PoPulATIoN – loNg-TErM ouTCoME oF 172 SHuNTED PATIENTSPyykkö O.T. BM1, Koivisto A. MD PhD3,4, Alafuzoff I. MD PhD3,5, Vainikka S. MD, Tamminen J. MD2, Tillgren T. MD2, Savolainen S. MD PhD2, Fraunberg M. MD PhD2, Pirttilä T. MD PhD3,4, Jääskeläinen J.E. MD PhD1,2, Soininen H. MD PhD3,4, Rinne J. MD PhD2, Leinonen V. MD PhD2

(1) Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland and University of Eastern Finland(2) Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland(3) Unit of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland(4) Department of Neurology, Kuopio University Hospital, Kuopio, Finland(5) Unit of Pathology, Department of Clinical Medicine, University of Eastern Finland, Kuopio, Finlando41. THE VAluE oF CErEBroSPINAl FluID DyNAMICS (CSF) AND ITS CorrElATIoN WITH TAP TEST For THE PrEoPErATIVE ASSESSMENT oF IDIoPATHIC NorMAl PrESSurE HyDroCEPHAluS (INPH) PATIENTS Aygok G.A.1, Kayis C.2, Marmarou A.1, Young H.F.1 (1) Department of Neurosurgery, Medical College of Virginia, Commonwealth University, USA(2) Department of Electrical Engineering, Virginia Commonwealth University, Richmond, VA, USAo42. CorrElATIoN BETWEEN TAP TEST rESulTS AND CSF AQuEDuCTAl STrokE VoluME IN IDIoPATHIC NorMAl PrESSurE HyDroCEPHAluSElSankari S.1,2, Fichten A.3, Gondry-Jouet C.4, Csoznyka M.5, Legars D.3, Deramond H.4, Balédent O.2

(1) Neurology Department, Amiens University Hospital, Amiens, France (2) Imaging and Biophysics Unit, Amiens University Hospital, Amiens, France(3) Neurosurgery Department, Amiens University Hospital, Amiens, France (4) Radiology Department, Amiens University Hospital, Amiens, France(5) Academic Neurosurgical Unit, Department of Clinical Neurosciences, University of Cambridge, Addenbroke’s Hospital, Cambridge, UKo43. TAP TEST - TIME WINDoW AND CoNSISTENCyVirhammar J.1, Cesarini K.G.2, Laurell K.1

(1) Department of Neuroscience, Uppsala University Hospital, Sweden(2) Department Neurology and Neurosurgery, Uppsala University Hospital, Sweden

Final Programme

o44. NEuroPSyCHologICAl CHANgES FolloWINg SHuNT TrEATMENT IN THE EuroPEAN MulTICENTrE STuDy oN INPHHellström P., Klinge P., Tans J., Wikkelsø C.Institute of Neuroscience and Physiology, Göteborg University, Sweden o45. CHArACTErIZATIoN oF urINAry INCoNTINENCE IN PATIENTS WITH NorMAl PrESSurE HyDroCEPHAluS (NPH) Klausner A.P.2, Aygok G.A.1, Young H.F.1, Boling P.A.3, Wolfe L.2, Koo H.P.2, Marmarou A.1

(1) Department of Neurosurgery, Medical College of Virginia Commonwealth University, Richmond, VA, USA(2) Department of Urology, Medical College of Virginia Commonwealth University, Richmond, VA, USA(3) Department Internal Medicine, Medical College of Virginia Commonwealth University, Richmond, VA, USAo46. ProPoSAl AND EVAluATIoN oF A CoMPuTErISED NEuroPSyCHologICAl TEST BATTEry For IDIoPATHIC NorMAl PrESSurE HyDroCEPHAluS (INPH)Behrens A.1, Eklund A.2,3,4, Elgh E.5, J. Malm1

(1) Department of Clinical Neuroscience, Umeå University, Sweden(2) Department of Biomedical Engineering and Informatics, Umeå University, Sweden(3) Centre for Biomedical Engineering and Physics, Umeå University, Sweden(4) Department of Radiation Sciences, Umeå University, Sweden(5) Department of Community Medicine and Rehabilitation, Umeå University, Swedeno47. ASSESSINg TrIAl DESIgN CHoICES IN A DEVICE-BASED AD EFFICACy STuDy: A PoST HoC ANAlySIS oF CHroNIC CSF DrAINAgESilverberg G. MD1, Saul T.1, Williams J. MD2

(1) Warren Alpert Medical School, Brown University, Providence RI, USA(2) Oxford University, Oxford, UKo48. THE VAlIDITy oF JAPANESE INPH guIDElINES IN A ProSPECTIVE STuDy oF INPH (SINPHoNI)Hashimoto M.1, Ishikawa M.2, Mori E.3, Kuwana N.4

(1) Noto General Hospital, Japan(2) Rakuwakai Otowa Hospital, Japan(3) Touhoku University Graduate School of Medicine, Japan(4) Tokyo Kyosai Hospital, Japan

10:30 – 10:50 Break with exhibitors

Session X NPH and shunts Moderators Mark Luciano, Konstantinos Polyzoidis

10:50-13:00 Oral presentations

o49. ATrIAl SHuNTS – NEuroSurgICAl ATAVISM or ESSENTIAl SECoND-CHoICE ProCEDurE?Aschoff A., Sakowitz O., Dictus C., Haux D., Steiner-Milz H.Department of Neurosurgery, University of Heidelberg, Germany

o50. DIVErSE MorPHology IN ArACHNoID CySTS INDICATES DIFFErENT EMBryologICAl orIgINRabie K.MD3, Tisell M. MD PhD2, Högfeldt M. MD2, Wikkelsø C. MD PhD3, Johansson BR. MD PhD1

(1) Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden(2) Department of Neurosurgery, Sahlgrenska Academy, University of Gothenburg, Sweden(3) Department of Neuroscience, Sahlgrenska Academy, University of Gothenburg, Swedeno51. CoNSErVATIVE VErSuS SurgICAl TrEATMENT oF IDIoPATHIC NorMAl PrESSurE HyDroCEPHAluSToma A., Papadopoulos M., Stapleton S., Kitchen N., Watkins L.o52. AMPlITuDES oF ICP PulSATIoNS IN A WIDE PrESSurE rANgEQvarlander S. MSc1, Malm J. MD PhD2, Eklund A. PhD1,3

(1) Department of Radiation Sciences, Umeå University, Sweden(2) Department of Clinical Neuroscience, Umeå University, Sweden(3) Department of Biomedical Engineering, Umeå University Hospital, Swedeno53. SyMPToMS AND SIgNS IN 158 PATIENTS WITH IDIoPATHIC NorMAl PrESSurE HyDroCEPHAluSTullberg M. MD PhD, Skagervik I. MD, Edsbagge M. MD, Hellström P. MSc, Blomsterwall E. RPt MSca, Wikkelso C. MD PhDHydrocephalus Research Unit, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Swedeno54. TEN yEArS oF EXPErIENCE WITH THE uSE oF ProgrAMMABlE AND FIXED PrESSurE VAlVES. A rETroSPECTIVE CoMPArATIVE STuDy oF 159 PATIENTSGatos H., Mpakopoulou M., Paterakis K., Fountas K.Department of Neurosurgery, University Hospital of Larisa, School of Medicine, Universityof Thessaly, Larisa, Greeceo55. A 25-yEAr-SErIES oF 700 PATIENTS WITH grAVITATIoNAl VAlVESVienenkoetter B., Haux D., Jung C.S., Unterberg A., Dictus C., Aschoff A.Department of Neurosurgery, University of Heidelberg, Germanyo56. SuBDurAl or INTrAPArENCHyMAl PlACEMENT oF loNg-TErM TElEMETrIC ICP MEASurEMENT DEVICES?Schmitt M., Eymann R., Antes S., Kiefer M.Department of Neurosurgery, Medical School, Saarland University, Homburg-Saar, Germanyo57. VENTrICuloATrIAl (VA) SHuNT CAN IMProVE SAFEly HIgHEr CorTICAl FuNCTIoN IN THE PATIENTS WITH IDIoPATHIC NorMAl PrESSurE HyDroCEPHAluS (INPH) Kiyoshi Takagi1,2, Katsuhiko Takeda3

(1) Department of Neurosurgery, Chiba-Kashiwa Tanaka Hospital, Japan(2) Department of Neurosurgery, Fujita Health University, Japan(3) Department of Neurology, Mita Hospital, International University of Health and Welfare, Japano58. VIrCHoW-roBIN SPACES IN IDIoPATHIC NorMAl PrESSurE HyDroCEPHAluS: A SurrogATE IMAgINg MArkEr For MICroVASCulAr DISEASE?Tarnaris A., Tamangani J., Fayeye O., Murphy H., Kombogiorgas D., Gan Y.C., Flint G.o59. BrAIN CT SCAN INDEXES IN THE NorMAl PrESSurE HyDroCEPHAluS: PrEDICTIVE VAluE IN THE ouTCoME oF PATIENTS AND CorrElATIoN To THE ClINICAl SyMPToMSStamatiou S., Chatzidakis E., Fratzoglu M., Barkas K., Markellos A., Voidonikolas L., Kyriakou T.Department of Neurosurgery, General State Hospital of Nikaia, Piraeus, Saint Panteleimon, Greece

Final Programme

o60. ProSAIkA - ProgrAMMABlE SHuNTASSISTANT IN INITIAl ClINICAl APPlICATIoN. DESIgN oF A ProSPECTIVE MulTICENTEr STuDyKehler U.1, Kiefer M.2

(1) Department of Neurosurgery, Asklepios Klinik Hamburg-Altona, Germany(2) University Homburg/Saar, Germanyo61. BrAIN loCAlIZATIoN oF lEuCINE-rICH α2 glyCoProTEIN AND ITS rolENakajima M.1, Miyajima M.1, Ogino I.1, Hagiwara Y.2, Arai H.1

(1) Department of Neurosurgery, Juntendo University School of Medicine, Japan(2) Department of Pathology and Oncology, Juntendo University, School of Medicine, Japan

13:00-13:30 Summary of the accomplishments of the meeting Harold L. Rekate, Kostantinos Kouzelis, Michael Pollay