6 – 9 may 2014 · barcelona · spain europact · pdf file6 – 9 may...

program and Book of aBstracts

6 – 9 May 2014 · Barcelona · Spain

Europact 2014 3rd European conference on process analytics and control technologywww.euro-pact.org

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Gesellschaft Deutscher Chemiker

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table of contents

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[email protected]

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VisiProDO Ex

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InsideTRANSMITTER

Page

SCIENTIFIC COMMITTEE 4

CO-ORGANISING GROUPS 4

CONFERENCE OFFICE 4

SPONSORS / EXHIBITORS 5

SIEMENS AWARD 5

PROGRAM At A GLANCE 6

PRE-CONFERENCE COURSES 8

LECTURE PROGRAM 9

POSTER PROGRAM 17

LECTURE ABSTRACTS 25

POSTER ABSTRACTS 83

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committee / organisation sponsors / exhibitors / award

sponsorsWe thank the following companies for their support.

goLd sponsor

sILVEr sponsor

exhibitorsThe following companies will participate in the exhibition (as of March 05, 2014):amphasys ag, Root, CHart photonics gmbH, Berlin, DBonsai advanced technologies sL, Madrid, EEndress+Hauser conducta gmbH+co.kg, Gerlingen, DHellma gmbH & co. kg, Müllheim, DHamILton Bonaduz ag, CHIndatEcH, Prades Le Lez, FIdEEL – Institut des Énergies décarbonées et des Écotechnologies de Lyon, FInnopharma Labs, Dublin, IRLinno-spec gmbH, Nürnberg, Dkaiser optical systems, Ecully, Fmagritek gmbH, Aachen, Dpolytec gmbH, Waldbronn, Ds•pact gmbH, Aachen, Dspectral Engines, Espoo, FINtec5 ag, Oberursel, DtracE analytics gmbH, Braunschweig, DVtt / promIs centre / University of Eastern finland, FIN

siemens awardSiemens Process Analytics Prize for Young Scientists

The German Working Group “Prozessanalytik” in cooperation with Siemens will award the 4th Siemens Process Analytics Prize to a young scientist for an outstanding publication in the field of Process Analytics.

The prize is endowed with € 1.500. A EuroPACT 2014 prize committee will select the winner. The award will be presented during the closing session.

scientific committeedr. pieter k. de Bokx Philips Research MiPlaza, Eindhoven, NLprof. Jose cardoso de menezes Technical University of Lisbon, Pdr. fabien chauchard Indatech, Prades Le Lez, Fprof. staffan folestad AstraZeneca, Mölndal, Sprof. anna de Juan capdevila University of Barcelona, Eprof. rudolf W. kessler Reutlingen University, Ddr. renata körfer DECHEMA e.V., Frankfurt am Main, Dprof. david Littlejohn University of Strathclyde, Glasgow, UKdr. michael maiwald BAM – Bundesanstalt für Materialforschung und -prüfung, Berlin, Ddr. per Öhrngren EUFEPS European Federation for Pharmaceutical Sciences, Järfälla, Sprof. romà tauler Spanish National Research Council (CSIC), Barcelona, E

co-organising groupsarBEItskrEIs proZEssanaLYtIk – Working Group Process Analyticscpact – Centre for Process Analytics and Control TechnologydEcHEma – Society for Chemical Engineering and Biotechnology e.V.apact – Advances in Process Analytics and Control TechnologycIs – China Instrument and Control SocietyEUfEps – European Federation for Pharmaceutical Sciencesgdch – German Chemical Society e.V.kncV – Koninklijke Nederlandse Chemische VerenigingnamUr – User Association for Automation in Process Industriespac – The Austrian research-network for Process Analytical Chemistry

conference officeDECHEMA e.V.Claudia MartzTheodor-Heuss-Allee 2560486 Frankfurt am MainGermany

Phone: ++49 (0)69 7564-129E-mail: [email protected]

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program at a glance

thursday 8 may 2014

Meeting room 9

08:30 plenary lecture: Thomas Steckenreiter

09:15 plenary lecture: Theodora Kourti

10:00 Coffee break

Meeting room 9 Meeting room 7+8

10:30WHat’s nExt for pat In tHE pHarmacEUtIcaL IndUstrY?

rEaL-tImE procEss pErformancE monItorIng

13:00 Lunch

14:00 poster short presentationssession d

poster short presentationssession c

14:45 poster sessions c+d at the exhibition area

15:30 – 17:30pat In rEaL LIfE manUfactUrIng

mULtIVarIatE procEss modELIng

19:30 Bus transport to dinner location

friday 9 may 2014

Meeting room 9

08:40 plenary lecture: Jean-Michel Roger


09:30 pat In agrofood and BIoprocEss anaLYsIs

ImagE anaLYsIs and procEss tomograpHY

10:30 Coffee break

11:30 pat In agrofood and BIoprocEss anaLYsIs


Meeting room 9

12:30 plenary lecture: Thomas de Beer

13:15 poster award, siemens prize, closing

13:30 Lunch

tuesday 6 may 2014

09:30 – 13:00 pre-conference courses 1-4 (Meeting rooms 1-4)

14:00 – 17:30 pre-conference courses 5-7 (Meeting rooms 1-4)

18:00 – 20:00 Registration & Set-up Exhibition/Posters

19:30 – 21:00 Welcome Reception at the exhibition area

Meeting room 9

20:00 evening lecture: Rudolf Kessler

Wednesday 7 may 2014

08:00 – 09:00 registration & opening

Meeting room 9

09:00 plenary lecture: Sune Svanberg

09:45 plenary lecture: Onno E. de Noord

10:30 Coffee break


11:00

procEss cHEmomEtrIcsnEW tEcHnoLogIEs

for procEss anaLYsIs

13:00 Lunch

Meeting room 9

14:00 plenary lecture: Hongfu Yuan

14:45 plenary lecture: Barry M. Wise

15:30 Coffee break


16:00



17:30 poster short presentationssession B

poster short presentationssession a

18:15 – 19:00 poster sessions a+B at the exhibition area

program at a glance

lecture program lecture program

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Page Page

Wednesday, 7 may 2014

08:00 registration

Meeting room 9

08:45 opening

Chair: F. Chauchard, Indatech, Prades Le Lez/F

09:00 plenary lecture Examples of advances in optical technologies and control

Sune Svanberg, Lund University/S, and South China Normal University, Guangzhou/CHN

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09:45 plenary lecture adventures in process data analysis and monitoring

Onno E. de Noord, Shell Global Solutions International B.V., Amsterdam/NL

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10:30 Coffee break




Chair: R. Tauler, Spanish National Research Council (CSIC), Barcelona/E

F. Chauchard, Indatech, Prades Le Lez/F

11:00 optimal strategies and tools for inter-pretation and variable selection in spectral profiles from process analysers O.M. Kvalheim, University of Bergen/N; R. Arneberg, Tel-Tek, Porsgrunn/N; O. Bleie, University of Bergen and Tel-Tek, Porsgrunn/N; F. Brakstad, Tel-Tek, Porsgrunn/N; T. Rajalahti, Haukeland University Hospital and University of Bergen/N; A.K. Smilde, J.A. Westerhuis, University of Amsterdam and Netherlands Metabolomics Center, Leiden/NL

30 mid-Ir quantum cascade lasers: new oppor tunities for process analytical chemistry B. Lendl, H. Moser, J. Waclawek, J. Ofner, C. Reidl-Leuthner, Vienna University of Technology/A; A. Genner, W. Ritter, B. Lendl, QuantaRed Technologies, Vienna/A

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11:30 fused stage-wise lasso – a waveband selection algorithm for spectroscopy B. Zauner, T. Natschläger, Software Competence Center, Hagenberg im Mühlkreis/A

31 sensitivity enhanced reflection raman spectroscopy for pat E. Ostertag, Reutlingen University/D; D. Oelkrug, University of Tuebingen/D; K. Rebner, R.W. Kessler, Reutlingen University/D

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12:00 capture, resolution and analysis of process trajectories: methodological consider-ations and practical examples A. Bogomolov, Global Modelling GmbH, Berlin/D and Samara State Technical Uni-versity/RUS; H. Meyer, J&M Analytik AG, Essingen/D; J. Mannhardt, art photonics GmbH, Berlin/D

32 Broadband photon time of flight spectros-copy: advanced spectroscopic tool for pat in pharmaceutical and dairy industries D. Khoptyar, Lund University/S; F. Kamran, O.H.A Nielsen, Technical University of Denmark, Roskilde/DK; S. Andersson-Engels, Lund University/S

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tuesday, 6 may 2014

09:00 Registration for Course Participants

09:30 – 13:00 pre-conference course 1: Barry M. Wise, Eigenvector Research, Inc., Wenatchee, WA/USA chemometrics without equations

09:30 – 13:00 pre-conference course 2: Jürgen von Frese, Data Analysis Solutions DA-SOL GmbH, Utting/D support Vector machines

09:30 – 13:00 pre-conference course 3: Oliver Reich, Roland Hass, InnoFSPEC Potsdam/D, Michael Maiwald, BAM, Berlin/D particle size monitoring using various techniques

09:30 – 13:00 pre-conference course 4: Fabien Chauchard, Indatech, Prades Le Lez/F; Dimitry Kophar, Lund; Suresh Thennadil, University of Strathclyde, Glasgow/UK spatially resolved spectroscopy: theoretical and chemometrics implementation for pat

13:00 – 14:00 Lunch for Course Participants

14:00 – 17:30 pre-conference course 5: Alberto Ferrer, Universidad Politecnica Valencia/E Introduction to multivariate statistical process control (mspc)

14:00 – 17:30 pre-conference course 6: Anna de Juan Capdevila, University of Barcelona/E; Romà Tauler, Joaquim Jaumot, Spanish National Research Council (CSIC), Barcelona/E multivariate curve resolution

14:00 – 17:30 pre-conference course 7: Jose Cardoso de Menezes, Technical University of Lisbon/P End-to-end business process excellence with pat and Qbd

18:00 – 20:00 set-up exhibition/posters

19:30 – 21:00 Welcome reception at Hotel Barcelo saints (with refreshments) & Evening Lecture

Chair: A. de Juan Capdevila, University of Barcelona/E

20:00 evening lecture perspectives in process analysis: science and fiction Rudolf W. Kessler, Reutlingen University/D

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Page Page


17:00 fuzzy finite state machine for multivariate calibration. application to near infrared spectroscopy C. Cernuda, E. Lughofer, University Linz/A; P. Hintenaus, W. Märzinger, i-RED Infrarot Systeme GmbH, Linz/A; T. Reischer, Dynea Austria GmbH, Krems/A; J. Kasberger, Recendt GmbH, Linz/A

38 continuous manufacturing of pharmaceutical tablets: the feasibility study of a pilot scale line S.-P. Simonaho, T. Ervasti, K. Pajula, Uni-versity of Eastern Finland, Kuopio/FIN; M. Toiviainen, M. Juuti, VTT, Kuopio/FIN; O. Korhonen, J. Ketolainen, University of Eastern Finland, Kuopio/FIN

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Chair: M. Maiwald, BAM, Berlin/D P.K. de Bokx, Philips Research MiPlaza, Eindhoven/NL

17:30 poster short presentationssession B: 2 min., 1 sheet

poster short presentationssession a: 2 min., 1 sheet

18:15 – 19:00

poster sessions a+B at the exhibition area


12:30 kernel-based models for batch process monitoring: an industrial case study R. Vitale, Universitat Politècnica de València/E; O.E. de Noord, Shell Global Solutions International B.V., Amsterdam/NL; A. Ferrer, Universitat Politècnica de València/E

33 new fiber-optical technologies for in-line characterization of chemical and biotechnolo gical processes O. Reich, L. Bressel, R. Hass, M. Münzberg, J. Wolter, M. Sandmann, University of Potsdam/D

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13:00 Lunch

Meeting room 9

Chair: M. Maiwald, BAM, Berlin/D

14:00 plenary lecture process analytical technology and its future in china

Hongfu Yuan, Beijing University of Chemical Technology/CHN

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14:45 plenary lecture model maintenance: the unrecognized cost in pat and Qbd

Barry M. Wise, Eigenvector Research, Inc., Wenatchee, WA/USA

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15:30 Coffee break


procEss cHEmomEtrIcs nEW tEcHnoLogIEs for procEss anaLYsIs

Chair: O.E. de Noord, Shell Global Solutions International B.V., Amsterdam/NL

P.K. de Bokx, Philips Research MiPlaza, Eindhoven/NL

16:00 a strategy for extracting information from historical process data F. Brakstad, Tel-Tek, Porsgrunn/N; O.M. Kvalheim, University of Bergen/N; R. Arneberg, Tel-Tek, Porsgrun and Pattern Recognition Systems AS, Bergen/N; B. Grung, University of Bergen/N

36 advanced bioprocess monitoring key to process and systems understanding G. Striedner, M. Luchner, University of Natu-ral Resources and Life Sciences, Vienna/A; R. Gutmann, Ionimed Analytik G.m.b.H, Innsbruck/A; K. Bayer, University of Natural Resources and Life Sciences, Vienna/A

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16:30 Blending process modeling and control by multivariate curve resolution J. Jaumot, CSIC-IDAEA, Barcelona/E; A. de Juan, University of Barcelona/E; J. Lallemand, S. Preys, Ondalys, Prades-le-Lez/F; B. Igne, J.K. Drennen, C.A. Anderson, Duquesne University, Pittsburgh, PA/USA

37 Quantum cascade laser spectroscopy for monitoring of ppb-concentration levels of phosgene M. Theuer, W. Kasten, BASF SE, Ludwigs-hafen/D; M. Nägele, OptoPrecision GmbH, Bremen/D

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Page Page

thursday 8 may 2014

12:30 model-based analysis and experimental validation of residence time distribution in twin-screw granulation A. Kumar, J. Vercruysse, University of Ghent/B; M. Toiviainen, P.-E. Panouillot, M. Juuti, VTT Technical Research Centre, Kuopio/FIN; V. Vanhoorne, VTT Technical Research Centre, Gent/B; K.V. Gernaey, Technical University of Denmark, Kongens Lyngby/DK; T. De Beer, I. Nopens, Univer-sity of Ghent/B

53 real-time fluorescence imagining analysis for inline quality control P. Holz, A. Brandenburg, M. Kemmler, FhI for Physical Measurement Techniques, Freiburg/D

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13:00 Lunch

Chair: D. Littlejohn, University of Strathclyde, Glasgow/UK

R. Körfer, DECHEMA e.V., Frankfurt am Main/D

14:00 poster short presentationssession d: 2 min., 1 sheet

poster short presentationssession c: 2 min., 1 sheet

14:45 poster session c+d at the exhibition area


pat In rEaL LIfE manUfactUrIngmULtIVarIatE procEss

modELLIng

Chair: S. Folestad, AstraZeneca, Mölndal/S

B.M. Wise, Eigenvector Research, Inc., Wenatchee, WA/USA

15:30 pat improves the production of biopharma-ceutical proteins in plants J.F. Buyel, RWTH Aachen University/D; A. Reimann, R. Fischer, FhI for Molecular Biology and Applied Ecology, Aachen/D

54 Improving industrial processes through advanced modelling of the reactions M. Maeder, A. Nguyen, University of Newcastle/AUS; G. Puxty, CSIRO Energy Technology, Mayfield West/AUS

64

16:00 msat strategies for business process excellence in pharma & biopharma: Qbd 2.0 J.C. Menezes, P. Felizardo, J. Machado, 4Tune Engineering Ltd, Lisbon/P

55 study of time-dependent structural changes of laponite colloidal system by means of nIr and hybrid hard- and soft-modeling mcr-aLs S. Mas, Universitat de Barcelona/E; R. Bendoula, G. Agoda-Tandjawa, Irstea, Montpellier/F; A. de Juan, Universitat de Barcelona/E; J.M. Roger, Irstea, Montpellier/F

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thursday 8 may 2014

Meeting room 9

Chair: D. Littlejohn, University of Strathclyde, Glasgow/UK

08:30 plenary lectureHow pat generates added value! Efficiency, quality, competitive advantage

Thomas Steckenreiter, Bayer Technology Services GmbH, Leverkusen/D

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09:15 plenary lecture pat in the pharmaceutical industry: a decade since fda’s guidance for industry on pat

Theodora Kourti, GSK

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10:00 Coffee break


WHat`s nExt for pat In tHE pHarmacEUtIcaL IndUstrY?


Chair: T. Kourti, GSK J. Cardoso de Menezes, Technical University of Lisbon/P

10:30 pharmaceutical production under the framework of the Qbd and pat initiatives: examples, challenges and benefits L. Liesum, A. Peinado-Amores, Novartis Pharma AG, Basel/CH

48 In-line monitoring of polymer content during microgel polymerization J. Meyer-Kirschner, J. Viell, M. Kather, A. Pich, W. Marquardt, A. Mitsos, RWTH Aachen University/D

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11:00 datamanagement and control strategies for continuous Bioproduction K. Francois, Siemens NV, Huizingen/B; I. Backx, Siemens NV, Zwijndrecht/B; B. Kavsek, Siemens AG, Vienna/A

49 Investigating the suspension polymerisation of styrene using raman spectrometry B.T. Robertson, M. Sanders, A. Nordon, D. Littlejohn, G. Emidio, Y.C. Chen, S.N. Thennadil, University of Strathclyde, Glasgow/UK

59

11:30 real-time inspection of pharmaceutical production processes S. Borchert, F. Stäudle, visiotec GmbH, Laupheim/D; H. Siesler, University of Duisburg-Essen, Essen/D

51 recent developments of medium resolution nmr spectroscopy for reaction monitoring applications N. Zientek, M. Maiwald, BAM Federal Insti-tute for Materials Research and Testing, Berlin/D; F. Dalitz, G. Guthausen, Karlsruhe Institute of Technology (KIT)/D; M. Kraume, Technische Universität Berlin/D

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12:00 Intelligent control and real time optimization of a multi step drying process K. Hong, M. Moshgbar, J. Huang, Pfizer Global Supply, Peapack, NJ/USA

52 combining fundamental knowledge with chemometric techniques for process monitoring – a hybrid modeling metho do-logy for pat M. von Stosch, R. Oliveira, University Nova de Lisboa, Caparica/P; J. Peres, S. Feyo de Azevedo, University do Porto/P

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Page Page

friday, 9 may 2014

Meeting room 9

Chair: A. Ferrer, Universidad Politecnica Valencia/E

08:40 plenary lecturenear infrared based technologies for agro, food and feed process monitoring

Jean-Michel Roger, Irstea, Montpellier/F

69

09:25 Time for room change


pat In agrofood and BIoprocEss anaLYsIs


Chair: A. Ferrer, Universidad Politecnica Valencia/E R.W. Kessler, Reutlingen University/D

09:30 strategies for use of historical process data for optimisation of industrial bioseparation unit operations A. Klimkiewicz, Novozymes A/S, Kalund borg and University of Copenhagen, Frederiks-berg/DK; C.B. Zachariassen, P.P. Mortensen, Novozymes A/S, Kalundborg/DK; F.W.J. van den Berg, University of Copen-hagen, Frederiksberg/DK

70 maize kernel density measurements with x-ray micro computed tomography (µct) M. Manley, A. Guelpa, T. Mokhoro, A. Du Plessis, Stellenbosch University, Matieland (Stellenbosch)/ZA

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10:00 off-line analysis and on-line monitoring of biopharmaceutical production processes with spectroscopic methods and multi-variate data analysis J.-P. Voss, N.E. Mittelheuser, Hamburg Uni-versity of Applied Sciences/D; M. Maiwald, Bundes anstalt für Material forschung und -pruefung, Berlin/D; R. Luttmann, Hamburg University of Applied Sciences/D

71 combination of laser-optical methods for inline dough rheology monitoring F. Perez Alvarado, M.A. Hussein, T. Becker, Technische Universität München, Freising/D

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10:30 Coffee break

Chair: A. Ferrer, Universidad Politecnica Valencia/E R.W. Kessler, Reutlingen University/D

11:00 combing on-demand data aggregation and multivariate modeling to improve control strategies for cell growth and product titers V. Shashilov, Accelrys, Lafayette/USA; C. Beckett, Umetrics, Crewe/UK

72 spatially resolved spectroscopy for real-time monitoring of apI concentration, density and dosage homogeneity of tablets B. Igne, J.K. Drennen, C.A. Anderson, Duquesne University, Pittsburgh/USA; F. Chauchard, INDATECH, Prades le Lez/F

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thursday 8 may 2014

16:30 ftIr analysis in oil oxidation process R. Leardi, University of Genoa/I; G. Polotti, Lamberti S.p.A., Albizzate/I

56 mechanistic modelling for process under-standing of fluidized bed drying process part of a full continuous pharmaceutical manufacturing line S.T.F.C. Mortier, Ghent University/B; T. De Beer, Ghent University/BY; K.V. Gernaey, Technical University of Denmark, Kgs. Lyngby/DK; I. Nopens, Ghent University/B

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17:00 – 17:30

What does it take to develop, implement and achieve regulatory approval of pat based control strategy and real-time release of solid oral product? P. Shah, Bristol-Myers Squibb, New Brunswick, NJ/USA

57 mcr-aLs study of actinides reduction in spent nuclear fuel reprocessing D. Kirsanov, St. Petersburg State University and University ITMO/RUS; C. Ruckebusch, LASIR CNRS - Université Lille 1/F; V. Babain, A. Lumpov, M. Agafonova-Moroz, Khlopin Radium Institute, St. Petersburg/RUS; A. Legin, St. Petersburg State University and University ITMO/RUS

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19:15 Bus transport to conference dinner

poster program

17

lecture program

16

Page

The Short Poster Presentation Sessions A and B take place on Wednesday 7 May 2014 at 17:30 h (2 min./1 slide per presentation). Followed by the Poster Sessions A and B from 18:15-19:00 h.

The Short Poster Presentation Sessions C and D take place on Thursday 8 May 2014 at 14:00 h (2 min./1 slide per presentation). Followed by the Poster Sessions C and D from 14:45-15:30 h.

poster number

short session Page


01 C real time monitoring and control of crystal shape A. Borsos, A. Majumder, Loughborough University/UK; Z.K. Nagy, Lough-borough University/UK and Purdue University, West Lafayette/USA

85

02 C terahertz Hyper spectral Imaging and multivariate data analysis deploying ImageLab H. Pühringer, Recendt GmbH, Linz/A; H. Lohninger, Vienna University of Technology/A; R. Holzer, S. Katletz, M. Pfleger, E. Schuhfried, K. Wiesauer, Recendt GmbH, Linz/A

86

03 C Infrared hyperspectral imaging combine with mcr-aLs for chocolate analysis X. Zhang, CSIC IDAEA, Barcelona/E; A. Juan, University of Barcelona/E; R. Tauler, CSIC IDAEA, Barcelona/E

87

04 C Electrical capacitance tomography imaging of wet granules during drying: temperature dependence of the data and scale-up of the sensor V. Rimpilainen, J.P. Kaipio, University of Auckland/NZ; T. Savolainen, P. Kaipio, L.M. Heikkinen, M. Vauhkonen, University of Eastern Finland, Kuopio/FIN

89

05 C Quantification and heterogeneity study of pharmaceutical nIr and fast raman images and multivariate analysis S. Piqueras Solsona, Universitat de Barcelona and CSIC-IDAEA, Barcelona/E; V. Olmos, Universitat de Barcelona/E; J. Burger, BurgerMetrics SIA, Rigga/LV; R. Tauler, CSIC-IDAEA, Barcelona/E; A. De Juan, Universitat de Barcelona, Barcelona/E

90

78 C Validation of diffusion models in dW-mrI images using mIa-mcrE. Aguado-Sarrió, J.M. Prats-Montalbán, Universitat Politecnica Valencia/E; R. Sanz-Requena, Hospital Quirón Valencia/E; L. Martí-Bonmatí, Hospital Universitari i Politècnic La Fe, Valencia/E; A. Ferrer, Universitat Politecnica Valencia/E

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friday, 9 may 2014

11:30 “snakes on a plane”: using time-dependent multivariable techniques to predict func-tional properties of milk powder in the control room V. Rimpilainen, J.P. Kaipio, I. Boiarkina, T. Munir, W. Yu, B. Young, N. Depree, University of Auckland/NZ; A. Prince-Pike, D.I. Wilson, Auckland University of Technology/NZ

73 monitoring and control of particle process-ing by Electrical capacitance tomography (Ect) L.P. Gradinarsky, AstraZeneca R&D, Mölndal/S; W. Yang, University of Manchester/UK; L. Cerullo, Chalmers University of Technology, Gothenburg/S; S. Folestad, AstraZeneca R&D, Mölndal/S

79

12:00 assessment of caramel colour in the scotch whisky industry using mid-infrared spectrometry and an attenuated total reflectance probe M. Holden, A. Nordon, D. Littlejohn, W. Johnstone, University of Strathclyde, Glasgow/UK; I. Goodall, C. Owen, Scotch Whisky Research Institute, Edinburgh/UK; G. Colquhoun, Fibre Photonics, Livingston/UK

74 the undecimated wavelet transform multivariate image analysis (UWt-mIa) for texture segmentation P.-M. Juneau, A. Garnier, C. Duchesne, Université Laval, Quebec/CDN

80

Meeting room 9

Chair: R.W. Kessler, Reutlingen University/D

12:30 plenary lecture future imaging and process tomography: pat for pharma and life science

Thomas de Beer , Ghent University/B

81

13:15 poster award, siemens prize, closing

13:30 Lunch

poster program poster program

18 19

poster number

short session Page

17 A monitoring of crystallisation using non-invasive broadband acoustic emission L. Palmer, N. Massey, C. Carrigan, J. Dunn, A. Nordon, D. Littlejohn, University of Strathclyde, Glasgow/UK

105

18 A real time analysis at high resolution with a small ft-Icr mass spectrometer J. Leprovost, G. Mauclaire, P. Boissel, AlyXan, Juvisy sur Orge/F; J. Lemaire, LCP, CNRS, Orsay/F; M. Heninger, LCP, CNRS, Orsay/F

106

19 A Quantitative nmr spectroscopy in the gas phase – applications for gas industry and metrology K. Meyer, M. Maiwald, BAM Federal Institute for Materials Research and Testing, Berlin/D; U. Panne, K. Rademann, Humboldt-Universität zu Berlin/D

107

20 - Evaluation of an ultra-compact nIr spectrometer for pharmaceutical product and process monitoring D. Bu, C. Corredor, G. McGeorge, D. Both, Bristol-Myers Squibb, New Brunswick, NJ/USA

108

21 - multimodal spectroscopic analysis of bioprocesses for inline detection of cell viability MULTISPEC Network partners/D; Sartorius Stedim Biotech GmbH, Goettingen/D; Reutlingen University, Leibniz University Hannover/D; art photonics GmbH, Berlin/D; Institut für Lasertechnologien, in der Medizin und Meßtechnik, Ulm/D

109

22 - novel microwave sensor systems for 2d and 3d monitoring of particle processing L.P. Gradinarsky, AstraZeneca R&D, Mölndal/S; L. Cerullo, J. Nohlert, J. Winges, T. Rylander, T. McKelvey, M. Viberg, Chalmers University of Technology, Gothenburg/S; S. Folestad, AstraZeneca R&D, Mölndal/S

110

23 - considerations for process raman spectrometer systems H. Eckhardt, C. Mattolat, tec5 AG, Oberursel/D

111

24 - process monitoring by real-time calorimetry J. Antes, S. Löbbecke, FhI for Chemical Technology, Pfinztal/D

112

pat In agrofood and LIfE scIEncEs

25 D In-line particle sizing and process characterization of highly concentrated polymer dispersions by photon density Wave spectroscopy M. Münzberg, J. Wolter, R. Hass, O. Reich, University of Potsdam/D

113

26 D a comparison of methods for Quality by design in bioprocess optimization M. von Stosch, C. de Azevedo, A. Marques, R. Oliveira, University Nova de Lisboa, Caparica/P

114

poster number

short session Page

nEW tEcHnoLogIEs for procEss anaLYsIs

06 A a new center of excellence in process analysis & technology K. Rebner, R.W. Kessler, Reutlingen University/D

92

07 A fiber spectroscopy for process-control from UV to mid Ir V. Artyushenko, J. Mannhardt, art photonics GmbH, Berlin/D

93

08 A spectroscopic techniques - enabling improvement for cell culture processes in miniature bioreactors R.C. Rowland-Jones, Newcastle University/UK; C. Jaques, Lonza Biologics, Slough/UK; E.B. Martin, Newcastle University/UK; A.J. Racher, Lonza Biologics, Slough/UK

94

09 A online-ethanol and online-methanol measurements in fermentation processes M. Hartlep, W. Künnecke, TRACE Analytics GmbH, Braunschweig/D; H. Penders, Sanofi-Aventis Deutschland GmbH, Frankfurt am Main/D

95

10 A from laboratory nIr models calibration to online low-cost process monitoring of diesel refinery pilot units N. Caillol, F. Baco-Antoniali, O. Delpoux, IFP Energies nouvelles, Solaize/F; M. Lacoue-Nègre, A. Bonhommé, K. Stiti, ISA - Université Lyon 1/F

96

11 A Heated sample line for special atEx requirements J. Erens, PSG Petro Service GmbH & Co.KG, Steinbach/D

97

12 A fast continuous flow titration J.G. Schramm, Hochschule Mannheim/D; R. Lehnig, C. Schwarz, BASF SE, Ludwigshafen/D

100

13 A High-throughput multiplexing gas chromatography – a new perspective for on-line process control K. Rebner, Process Analysis & Technology (PA&T), Reutlingen/D; R. Lehnig, BASF SE, Ludwigshafen/D; A. Siegle, O. Trapp, Heidelberg University/D

101

14 A the evaluation of twin-screw granulation as a continuous blending tool by means of the moving f-test M. Fonteyne, J. Vercruysse, J.P. Remon, C. Vervaet, T. De Beer, Ghent University/B

102

15 A Innovative concepts for on-line titration N. Richter, BASF SE, Ludwigshafen/D; J.G. Schramm, Hochschule Mannheim/D; R. Lehnig, BASF SE, Ludwigshafen/D

103

16 A non-invasive monitoring of powder drying by broadband acoustic emission spectrometry in comparison with spectroscopic techniques D. Logue, L. Wurker, J. Dunn, A. Nordon, D. Littlejohn, University of Strathclyde, Glasgow/UK

104


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37 - pat data management as a tool to support continuous production in secondary manufacturing K. Francois, I. Backx, J. Verelst, Siemens NV, Huizingen/B

126

38 - characterization of recycled tire fibers by diffuse reflectance spectroscopy combined with chemometric tools B. Boldrini, N. Fritz, T. Goll, K. Nebel, K. Rebner, R.W. Kessler, Reutlingen University/D

127

procEss cHEmomEtrIcs and mULtIVarIatE procEss modELLIng

39 B modelling the relationship between chemical properties and process performance to develop predictive models to support operations K. Ferguson, C.J. Steele, F. Wright, Sellafield Ltd, Seascale/UK; A. Wood, J. Zhang, Newcastle University/UK

128

40 B a new multi-block pLs algorithm including a sequential pathway J. Lauzon-Gauthier, C. Duchesne, Université Laval, Quebec/CDN

130

41 B pharmaceutical blend monitoring and end-point determination by near-Infrared spectroscopy using a qualitative approach J. Lallemand, S. Preys, Ondalys, Prades-le-Lez/F; J. Jaumot, A. De Juan, University of Barcelona/E; B. Igne, J.K. Drennen, C.A. Anderson, Duquesne University, Pittsburgh, PA/USA

131

42 B How Indirect Hard modeling (IHm) complements chemometrics: operating conditions and applications D. Engel, C. Minnich, S-PACT GmbH, Aachen/D; M.-P. Feth, Sanofi-Aventis Deutschland GmbH, Frankfurt am Main/D; L. Helmdach, J. Ulrich, University of Halle-Wittenberg/D

132

43 B the pure analyte signal from oblique projection and its process modeling Z. Yao, H. Yuan, A. Hu, H. Su, Guangxi University of Science and Technology, Liuzhou, Guangxi/CHN

133

44 B study of carbamazepine photodegradation by spectroscopic, chromatographic and chemometric techniques V. Olmos, A. Marqueño, S. Mas, A. de Juan, University of Barcelona/E

136

45 B In situ process control of a fed-batch biotransformation by means of atr-fourier transform Infrared spectroscopy S. Baum, Hamburg University of Technology/D; M. Schilling, F. Cabirol, Evonik Industries AG, Essen/D; D. Sellin, L. Hilterhaus, A. Liese, Hamburg University of Technology/D

138

46 B a novel strategy to evaluate the quality of traditional chinese medicines based on chromatographic fingerprint and chemometrics methods P. Wang, L. Nie, H.C. Zang, Shandong University, Jinan/CHN

139

poster number

short session Page

27 D Inline characterization of bioprocesses during curdling of milk, beer mashing and blood deoxygenation by photon density Wave spectroscopy R. Hass, D. Munzke, O. Reich, University of Potsdam/D

115

28 - geographical traceability models based on mIr spectroscopic markers to discriminate among spanish protected extra virgin olive oils J.M. González-Sáiz, I. Esteban-Díez, S. Rodríguez-Tecedor, C. Pizarro, University of La Rioja, Logroño/E

116

29 - modulation of red wine color during accelerated aging by controlling process variables J.M. González-Sáiz, I. Esteban-Díez, N. Pérez-del-Notario, I. Arenzana- Rámila, C. Pizarro, University of La Rioja, Logroño/E

117

pat In rEaL LIfE manUfactUrIng

31 D Business productivity improvement through the application of analyser device Integration E. Raut, Newcastle University, Newcastle upon Tyne and ABB, St. Neots/UK; C. Hobbs, ABB, St. Neots/UK; E. Martin, Newcastle University, Newcastle upon Tyne/UK

118

32 D process control of stock preparation process in a paper mill by nIr monitoring of recovered paper E. Pigorsch, G. Gärtner, PTS Papiertechnische Stiftung, Heidenau/D

120

33 D application of spectroscopic methods in the continuous industrial process viscose fibre production G. Mayr, F. Zeppetzauer, Competence Center for Wood Chemistry and Wood Composites (Wood K plus), Linz/A; P. Hintenaus, H. Trinker, University Salzburg/A; W. Märzinger, J. Kowalski, iRED-Infrared Systems, Linz/A; T. Röder, Lenzing AG/A

122

34 D online monitoring of batch processes F. Westad, L. Gidskehaug, G.R. Flåten, Camo Software AS, Oslo/N; B. Swarbrick, Camo Software AS, Woodbridge, NJ/USA

123

35 D process control in the food and feed value chain M. Graeber, M. Heine, M. Agarwal, B. Conde-Petit, J. Lisner, M. Hersche, Buhler AG, Uzwil/CH

124

36 D Integration of dielectric spectroscopy with other spectroscopies to enhance monitoring and control of mammalian cell cultivations P. Felizardo, J. Mendes, F. Folque, 4Tune Engineering Ltd, Lisbon/P; S. Buziol, M. Roth, C. Jung, Roche Diagnostics GmbH, Penzberg/D; J.C. Menezes, 4Tune Engineering Ltd, Lisbon/P

125


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57 C nIr spectroscopy for in-line blend uniformity evaluation in the feed frame of a tablet press F. De Leersnyder, E. Peeters, C. Vervaet, J.P. Remon, T. De Beer, Ghent University/B

150

58 C monitoring of biogas plants using inline-atr-ftmIr spectroscopy C. Wolf, University of Applied Sciences Cologne, Gummersbach/D; S. Janz, M. Balsam, A. Rehorek, University of Applied Sciences Cologne, Leverkusen/D; M. Bongards, University of Applied Sciences Cologne, Gummersbach/D

151

59 C mechanistic modelling of enzymatic biodiesel production for fed batch control J. Price, M. Nordblad, J.M. Woodley, J.K. Huusom, Technical University of Denmark, Kgs. Lyngby/DK

152

60 C 100% monitoring of manufactured tablets with nIr chemical imaging P.R. Wahl, O. Scheibelhofer, S. Sacher, RCPE GmbH, Graz/A; P. Kerschhaggl, EVK DI Kerschhaggl GmbH, Rabba/Graz/A; J.G. Khinast, RCPE GmbH and Graz University of Technology/A

153

61 C In-line mammalian cells culture monitoring: comparison of predictive performances offered by nIr and raman spectroscopies D. Didion, A.-L. Hantson, University of Mons/B

154

62 C statistical process monitoring of a continuous pharmaceutical twin screw granulation and drying process A.F. Tavares da Silva, Ghent University/B and University of Porto/P; J. Vercruysse, Ghent University/B; P. Cappuyns, Janssen Pharmaceutica, Beerse/B; J.A. Lopes, University of Porto/P; C. Vervaet, J.P. Remon, T. De Beer, Ghent University/B

155

63 C online monitoring of emulsion polymerization with raman spectroscopy, conductivity and mass spectroscopy C. Houben, A.A. Lapkin, University of Cambridge/UK

156

64 C process control of semi-batch emulsion polymerizations by atr-ftIr, raman and calorimetry P. Broege, W. Pauer, H.-U. Moritz, University of Hamburg/D

157

65 C monitoring and control of continuous and periodic flow crystallization in msmpr using process analytical technologies (pat) and crystallization process Informatics system (cryprIns) K.A. Powell, A.N. Saleemi, C.D. Rielly, Loughborough University/UK; Z.K. Nagy, Purdue University, West Lafayette/USA

158

poster number

short session Page

47 B on-line atr mIr spectroscopy of bio catalysis in two phase system J. Hospital, K. Spornhauer, A.C. Spieß, RWTH Aachen University/D

140

48 B on-line measurement of reaction components and control of recycle ratio using ft-nIr spectroscopy E. Mantovani, University of Modena and Basic Chemical & Plastics Research Centre, versalis s.p.a., Mantova/I; F. Bonacini, A. Ferrando, Basic Chemical & Plastics Research Centre, versalis s.p.a., Mantova/I

141

49 B mcr-aLs: a useful tool for bioprocess understanding A. Folch-Fortuny, Universitat Politècnica de València/E; M. Tortajada, Biopolis S.L., Valencia/E; J.M. Prats-Montalbán, J. Picó, A. Ferrer, Universitat Politècnica de València/E

142

50 B dyam: software tool for mixture optimization D. Palací, A. Ferrer, Universidad Politécnica de Valencia/E

143

51 B multivariate modeling and doE for on-line and at-line near-Infrared (nIr) methods to support the real time analytics strategies C. Corredor, D. Bu, G. McGeorge, D. Both, P. Shah, Bristol-Myers squibb, New Brunswick, NJ/USA

144

52 B spatial investigation of Uf membrane residual-fouling in full scale dairy production using ft-Ir to quantify protein and fat residuals J.K. Jensen, F. van den Berg, University of Copenhagen, Frederiksberg C/DK

145

53 B relationship between processing parameters and critical to quality attributes A. Hertrampf, H. Müller, Merck KGaA, Darmstadt/D; J.C. Menezes, Institute for Biotechnology & Bioengineering, IST, Lisbon/P; T. Herdling, Merck KGaA, Darmstadt/D

146

54 - Quality assessment of wastewater treatment plant effluent based on a multi-parametric UV LEd monitoring system S. Platikanov, Spanish National Research Council, Barcelona/E; S. Rodriguez- Mozaz, B. Huerta, D. Barcelò, Catalan Institute for Water Research, Girona/E; J. Cros, M. Batle, ADASA Sistemas S.A.U, Barcelona/E; G. Poch, TRARGISA, Girona/E; R. Tauler, Spanish National Research Council, Barcelona/E

147

55 - a nondestructive near infrared spectroscopy method to identify the foods containing trans-fatty acids C. Song, H. Yuan, J. Xie, X. Li, Beijing University of Chemical Technology/CHN

148

56 - studies of the unfolding and protonation processes of cytosine-rich dna sequences using multivariate analysis methods S. Benabou, University of Barcelona/E; A. Aviñó, R. Eritja, IQAC-CSIC, Barcelona/E; R. Gargallo, University of Barcelona/E

149

25

abstractsLectures

24

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66 C application of process analysis technology (pat) during the production of modern traditional chinese medicine prescriptionG. Luo, Y. Wang, Tsinghua University, Beijing/CHN

160

67 - the in-line measurement of plant cell biomass using radio frequency impedance spectroscopy as a component of process analytical technology T. Holland, D. Blessing, S. Hellwig, R. Fischer, FhI for Molecular Biology and Applied Ecology, Aachen/D; M. Sack, RWTH Aachen University/D

162

68 - In-situ spectroscopy of multiphase reactions from sugars to platform chemicals T. Eifert, M.A. Liauw, RWTH Aachen University/D

163

69 - real time monitoring and control of bioprocesses M. Hoehse, J. Fernandes, C. Grimm, Sartorius Stedim Biotech GmbH, Goettingen/D

164

70 - pat data management to enable advanced process monitoring and control on hot melt extrusion lines J. Baronsky-Probst, Grünenthal GmbH, Aachen/D; K. Francois, Siemens NV, Brussels/B

165

sYstEms IntEgratIon for IntELLIgEnt manUfactUrIng

73 A combined use of raman and atr-UV/Vis to obtain the desired polymorphic form of anthranilic acid E. Simone, A.N. Saleemi, Loughborough University/UK; Z.K. Nagy, Purdue University, West Lafayette/USA

166

WHat`s nExt for pat In tHE pHarmacEUtIcaL IndUstrY?

74 D small scale bioproduction: application of pat and process control B. Kavsek, Siemens, Vienna/A; K. Francois, Siemens, Huizingen/B

167

75 D a pat approach for the on-line monitoring of pharmaceutical co-crystals formation with near infrared spectroscopy M. Sarraguça, Universidade do Porto/P; P. Ribeiro, Universidade Federal do Maranhão, Imperatriz/BR; J. Lopes, Universidade do Porto/P

168

76 D multi-spectroscopic approach for the analysis of dissolution profiles of pharmaceuticals N. Zientek, M. Albrecht, K. Meyer, L. Tröbs, M. Maiwald, A. Paul, BAM Federal Institute for Materials Research and Testing, Berlin/D

169

77 D monitoring of batch and continuous crystallisation using non-invasive raman spectrometry L. Palmer, A. Nordon, D. Littlejohn, University of Strathclyde, Glasgow/UK

171

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6 – 9 may 2014 · barcelona · spain europact · pdf file6 – 9 may...

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