9.3 cell cycle regulation what you will learn -how cancer relates to the cell cycle -the role of...
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9.3 CELL CYCLE REGULATION
WHAT YOU WILL LEARN-How cancer relates to the cell cycle-The role of apoptosis-Types / Uses of stem cells
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READING Q’s
NAME-When are some of the important combinations active?
-mitosis and interphase (G1, S, G2)
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READING Q’s
DEFINE-What is cancer?
-the uncontrolled growth and division of cells
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READING Q’s
IDENTIFY-What is an example of a carcinogen that occurs in nature?
-ultraviolet radiation from the SUN
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READING Q’s
IDENTIFY-Which statement about apoptosis is correct?
A- Apoptosis can lead to cancer.
B- Apoptosis can prevent cancer.
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READING Q’s
DESCRIBE-What are stem cells?
-unspecialized cells that can develop into a variety of specialized cells
http://www.youtube.com/watch?v=cs2cNLNMjN0
Bill Nye Greatest Discoveries—CELL DIVISION
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GROUP WORK: APPLICATION NOTES
-As a group complete the application notes using your knowledge from the reading.
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9.3 MAIN IDEA
Normal cell cycle is regulated by cyclin proteins
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9.3 CELL CYCLE REGULATION
WHAT YOU WILL LEARN-How cancer relates to the cell cycle-The role of apoptosis-Types / Uses of stem cells
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READING Q’s
DEFINE-What is cancer?
-the uncontrolled growth and division of cells
NORMAL CELL CYCLE
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NORMAL CELL CYCLE
SUMMARIZE: How cells regulate the cell cycle.-Cells use _______________ and _______________ to control the cell cycle.
-Different combinations of _______________ start the cell cycle at different _______________.
-The cell also uses _______________ to monitor the cycle for quality control.
-In _______________, the cell checks the DNA for damage. If there is any damage, the cycle won’t proceed to _______________.
-In _______________, the spindle fibers are malfunctioning, the cycle won’t proceed to ___________.
CDK-Cyclin dependent kinases
mitosis
G1 stageS stage
cytokinesis
cyclins
cyclin/CDKcheckpoin
ts cyclin/CDK
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CANCER CELL CYCLE
SEQUENCE:The cause/effects of cancer
A failure in regulation of cell cycle
uncontrolled growth/division of cells
cancer cells go unchecked
crowding out normal cells--leading to tissue/organ failure
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SUMMARIZE
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ABNORMAL CELL CYCLE
IDENTIFY:Four environmental factors that cause cancer.
1-__________________________
2-__________________________
3-__________________________
4-__________________________http://www.youtube.com/watch?v=IeUANxFVXKcUnregulated cancer cell growth
CIGARETTE SMOKE/TOBACCO
ASBESTOS
X RAYS
ULTRAVIOLET RADIATION
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APOPTOSIS
SUMMARIZE: Information about apoptosis-APOPTOSIS IS--process of programmed cell deathOrganisms use apoptosis to--destroy cells that are no longer needed -destroy cells damaged beyond repairProcesses that use apoptosis (examples)-
1-trees losing their leaves in autumn2-development of hands and feet in
embryo
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READING Q’s
IDENTIFY-Which statement about apoptosis is correct?
A- Apoptosis can lead to cancer.
B- Apoptosis can prevent cancer.
APOPTOSIS
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READING Q’sAPOPTOSIS
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READING Q’s
1-”triggers” in body send signals for cell death[viruses/free radicals/stress/radiation]
2-capsases [proteins]:-break down cell components-produce DNases—destroys DNA in nucleus
3-cell shrinks and sends “distress” signals4-macrophages ingest/clean away shrunken cells
APOPTOSIS
http://www.youtube.com/watch?v=7WRkY8q_F3k
http://www.youtube.com/watch?v=xkASer3gEnc
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STEM CELLS
LIST: Write three facts you discovered about stem cells
1-unspecialized cells that can develop into a variety of specialized cells
2- 2 types: adult & embryonic
3- can be directed to a specific type of cellhttp://www.youtube.com/watch?v=cs2cNLNMjN0
Bill Nye Greatest Discoveries—CELL DIVISION
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STEM CELLS
COMPARE/CONTRAST: Adult and embryonic stem cells
-comes from various tissues in body-present from infancy thru adulthood
-unspecialized cells that have potential to become specialized
-100-150 cells formed after fertilization-become specialized as embryo grows
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SUMMARIZE
COMPLETE: A=apoptosis S=stem cells___ 1-After a sperm fertilizes an egg, the resulting mass of cells divides until there are about 100-150 cells.
___ 2-Some cells go through a programmed death.
___ 3-Embryonic cells shrivel and die, resulting in the formation of fingers and toes.
___ 4-Unspecialized cells are either embryonic or adult.
___ 5. This event occurs in cells that are damaged beyond repair.
S
A
A
S
A
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SUMMARIZE
EXPLAIN: How cancerous cell growth differs from normal cell growth-The cancer cell cycle is much faster than the normal cycle.
-interphase is dramatically shorter in cancer cells
NORM stomach cellsCANCER stomach cellsInterphase 120 min 16 minProphase 60 min 15 minMetaphase 10 min 2 minAnanphase 3 min 1 minTelophase 12 min 3 min
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CANCER DRUGS
OVERVIEW:-damage DNA
work in all phases of cell cycle-interfere w/DNA & RNA growth by replacing building blocks
destroy cell in S phase-interfere w/enzymes involved in DNA replication
work in all phases of cell cycle-inhibit enzymes needed to make proteins in cell cycle
work during MITOSIS, can damage cells at all stages
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ILLUSTRATE