-~s reql.!ired by law (7 USC 2143). Failure to report according to the regulations canresult,n an order to cease and desist and to be subjeclto penalties as provided for in Section 211

DEC () 2 ?On~ //\ t- '( olUU.5. ~ee attached form for Interagency Report COI\trol No.:

additional information.

UNITED STATES DEPARTMENT OF AGRICUL.TURE 1. CERTIFICATE NUMBER: 31-F-0003 FORM APPROVED ~ANIMAL AND PLANT HEAL.TH INSPECTION SERVICE OMB NO. 0579--0036

CUSTOMER NUMBER: 451

U.S. Environmental Protection AgencyANNUAL REPORT OF RESEARCH FACILITY National Exposure Research Lab

(TYPE OR PRINT) 26 W. MU<ing Drive.1 - n,a, 1I.~~n~ •.."'- "

.National E~o"SlmrRese8fdl..Laboratofy--·Cincinnati, OH 45268

3. REPORTING FACILITY (List all locations where animals were hOused or used In actual research, tasting, or eJqlerirnenl8tion, or held for these purposes. Attach addili0J\81 sheels if necessary ) IFACILITY LOCATIONS ( Sites) - See Atached listing

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach Iddltlonll sheets if necessarY or use APHIS Form 1023A I IA. B. Number of animal C, Number of D. Number of animals upon E. Nufri)er of animals upon which teaching, experiments, F.

being bred, animals upon v.tlich experiments. research, surgery or tests were conducted invoillingconditioned, or v.tllch teaching, teaching, research, accolJ1lilnying pain or distress to tha aninls and fOr wh

TOTAL NUMBERAnimals Covered held for use In research, surgery, or tests were the use of appropriate anesthetic, analgeSiC, or tranquili2

OF ANIMALSBy The Animal teaching, testing, eJqleriments, or conducted inYOlliing drugs would have adversely affected the procedures, res

Welfare RegulaUorw experimel1ts, teslsware aCCOlTl*1ying pain or or Inlerprelation of the teaching, research, experiments,research, or conducted dlslJess III the animals an surgery, Dr tests, (An explanation of the procedures ( COLUMNSsurgery but not lit Involving no pain, for which appropriate producing pain or distress in these animals and the rease C+D+E)used for such distress, or use 0- anesthetic, analgesiC, or such drugs were not used nuS! be attached to this repor!purposes. paln-rell8\ling tranquilizing drugs ware

drugs. used.----

4. Dogs 0 0 () 0 05. Cats n 0 C) 0 C)6. Guinea Pigs n 0 0 0 07. Hamsters 0 () 0 0 C)

8. Rabbits 0 () 0 C> 0--9. Non-human Primates 0 n 0 0 010. Sheep (J 0 0 0 ()11. Pigs () 0 0 0 012. Other Farm Animals 0 0 0 cJ 0

-

13. Other AnimalS 0Ge.rbi Is. lJ () t') 8b () G8<Q1'V\ ~ c. e <..""<"; 0 .J...;~ 50 r', :J. a-56-

·7.ebn.l'fs~ .500 Cl ' S-CD 0 I/ OO()

I ASSURANCE STATEMENTS I1) Professionally acceptable standards goveming the care, treatment, and use of animals, including appropriate use of anastetic, analgesic, and tranqu~izjng drugs. prior to, during, and following actual res«

teaching, tes~ng, surgery, or experimentation were followed by this research facility.

2) Each principal investigator has considered altematives to painful prooeclures.

3) This facility's adhenng to the standards and regulations under the Act, and it has required lIlat exceptions to the standards and regulations be specified and explained by tha principal investigator and apInstitutiOnal Animal Care and Use CofrTrilleG (IACUC). A IU/IllNIry of all Iuch excepUons Is attactled to this annuall'llPOrt- In addition to Identifying the lACU(;..approved exeep/iOl\s. this SUlTV1'\ilCY incbnef explanation of the exceptions, as welt as the species and nufri)er of animals affected.

4) The attending veterinarian for this research facility has appropriate authocity III ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and use.

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL( Chief Executive Officer or legally Responsible Institutional OffIcial)

-------- -- ------- ---- --------- ---- --------------------- -------------- - ------- -- ------- ------- M~er Ch(l,~r ------- -

---- ----- I~J..,t:.crlc( -- ---------- --- -----

DATESGNEO

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Inleragency RepOrt Control No01SO OOA-AN

See reverse side loradditional ,nformation

ThiS ,.porI is reqUifed by law (7 uSC 21431. Failure to report according to lIle regulallons cand n6 d 's! d 10 b bjec1 to penalties as prollided for ill section 2150resuilin an or er 10 cease a e$l an esu .

UNITED STATES DEPARTMENT OF AGRICULTURE 1, REGISTRATION NO. CUSTOMER NO. I FORM APPROVEDANIMAL AND PLANT HEALTH INSPECTION SERVICE '31-F- 0003 /·1--5 l 0"15 NO, 0579-0036

CONTINUATION SHEET FOR ANNUAL REPORT2. HEADQUARTl!A5 RESEARCH FACILITY (Nam. and Address, as regislered wdh USCA,

ifIcJlWfI Zip Code) . R . t AOF RESEARCH FACILITY V.S;, ffHt~nmefl-r..( ,.:'te..~ ,on ,gencj

(TYPE OR PRINT) 1C;, \/v. L i<.fl1 1> f' .

L,."\ejol1ai" OU 4-S~.l~g 1E'ISI?>5~·9·7m

REPORT OF ANiMAlS USED BY OR UNDER CONTROL OF RESEARCH FACIUTY (Altacll addMlonal sh••'s if n.cosswy or use this form.)

A, B. Nunilerd C. N~erof D. Number 01 anlr1'llls upon E. Number oIeni!T1lls upon wtr.ch leeching. F..nimals being anomllis upOn which explltlmenll, experiments, reseanell. surgery or lests were

Animals Covered bred, WhiCh leaching, leaching, reManell. conducted in~ol~ing acc0r!'4l8ny,nll pain or diStress TOTAL NO.By The Aflimal condit,oned. or r_arch. surgery. or leslS were 10 th4l 8tllmals and for which the use 01 appropriate OF ANIMALS

Welfare Regulations held tor use in expenmenls. or conducted Ilwolving aneslhetic.lnalgesk:. or ''Ilnquihzing drugs WOlIldteactllng, les~ng. lesls were accompanying pain or ~a~. adversely affected the p«lctdures, resulls. or (Cois. C.expenmenls. conducled <listress to the InltTWlS interprelllbon 01 the teaching, research. D + E)research. or invtaVtng no and fer wh'ch appropriate exp"mnenll. surgery. or lests. (An e""/.".t/Oll ofsurgery but nol pain, distreSS. or anesthetic, analgesic, or the ptOCedfJre,~ pain or dIStress in /f'I.s.yet used tor such UI, of pain. lranquillzing drugs were anm.t.1IIl11 the reaSOll. such I1rugs ..- no/usedpurposes. relieving dlUgs. used. muSf be .ttllChf1d 10 this reporl)

p, )lle<.l.ll ~,nfi>h 0 0 /oC4 0 /00It;d·}1.....)-'Ill; n no '. !~ goon 0 .30.0DC) 0 3CfOOQ

r -.

ASSURANCE STATEMENTS

1) Profe..lonally acceptable $Iandards govemrng the care, trealmrtnC. and us. ot an,,,..,II, Including apPropnal. use of aneslh"hc. analgeSC. and IranQulti..ng drugs, pnor to. dUfln9,~nd followrng aOlual research. lear;hjng. lesUng, surgery, or experimentallon were followed b)/ thIS research fac,lity.

2) Each ",,"clpal ",~esbgalorhas conSIdered all4lmati~. to painful proclldures.

31 T~,s faclilly IS adheong 10 the Slan<larns and rl!glJl.lIons under Ihe Acl, and il has required lhal excepl,ons to the Slandards ana regUlations be specIfied and explaIned by lhepnneipal ,n·'.51Igalor and appro~ed by lhe Inslilutional An'l\""8l Care and Use Conmtlee (lACUCI. A .~mmary of .U the uc.pUone I. alllctlacl to thl. In.....1r.port. In.,Jd,lion 10 ,d@{llifyirg the IACUC·.ppro~ eoeephons. thl. SUtml8ry ,ndudes a ~net eMplanaUon oIlhe exceptions. as well as [he speCies and number 0' animall affected.

'4) The ••lIcnd'"9 ,cte""ar,an lor IhlS ,.•••rch fachly hal appropcate .I>lhorily Ie ""sote Ihe pro......on ot adequale ,,"(ericary care and Ie o_seelhe adequacy of oth.r.):s~ecls of anlma1 care find use.

CERTIFICATION BY HEADQUARTERS RESEARCH FACIUTY OFFICIAL(Chief Executive Officer or Legally Responsible Institutional official)

: certify thai the above is true. correct, and complete (7 U.S.C. Section 2143)

-------- - - ---- ADQUARTERS

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