A better world for older people is a better world for everyone

Research into action

Old age has historically been accompanied by

ill health

Understanding thebiology of ageing will change things

for the better

It doesn't have to be that way

But only if you

help us

What we came here to say

Life expectancy: a brief history

1900 Global averages

1950

1990

Today

2050 UN forecast

2100

Middle/upper-middle class

Good health, socially active

Gym, wine club or similar

Interested in change

Keeping up to date

Satisfied innovators

Former manual workers

Dependent on state pension

Poor health, multiple medicines

Socially isolated

Lots of TV

Old age: a time of satisfaction or struggle?

Bored and depressed

Some old people are so happy, healthy and wealthy they should be helping us

But many others

are not

Health is a key determinant of happiness

Poor health costs money and

causes misery

The situation today

Health costs today

Cost of items dispensed by NHS

Admissions to NHS hospitalsof people over 65

60%

£8.4bn

£5.5bn of which spent on older patients

1900 Global averages

1950

1990

Today

2050 UN forecast

2100

Life expectancy: a brief history

Success brings its own problems

Number of people with chronic conditions

Health costs tomorrow

UK health care

UK long-term care

Spending increase per capita

Age increases vulnerability to disease and functional impairment. We have known this happens for a long time but not why.

We now know enough about the physiology of ageing to extend healthspan.

You can help us do important things for older people now and transformative things later.

It doesn't have to be this way

Mechanisms that maintain health are shared between species

InsectsInvertebrates HumansMice

Shift focus on research

Sicknessand death

OthersMenopause,

hearing loss, joint stiffness, immune

diseases

Natural changes

Grey hair, wrinkles, weakness

Diseases of ageingAlzheimer’s

CancerCardiovascular

Parkinson’sMacular degeneration

Type II diabetesOsteoporosis

A few ageing mechanisms

In 2009 Science identified healthy lifespan extension byrapamycin as one of the most significant breakthroughs that year.

Live long and prosper

Extended potential healthspan

Rapamycin-treated miceControl

Survival rate of male mice

Survival rate of female mice

0 days 1400 0 days 1400

Rapamycin improves health

Infection after hip fracture

Hip fracture in previously independent, healthy older people

No infection Chest Wound UTI

A simple supplement could stop this

DHEA levels decline with age

Serum DHEAs Cortisol

20 years old 40 60 80

4

8

12

16uM

Control Trauma Trauma +5 weeks

Trauma suppresses neutrophil bactericidal function in older people

Old Young

2

6

10

14

Superoxide CPM

Cells treated with drug SB203580

Normal + drugNormal Disease

Disease + drug

Cell growth Cell growth

0 days 100 0 days 100

A cure for accelerated ageing

Removing senescent cells improves health

Removing senescent cells in mice increases exercise capacity

Old mouse with senescent cells removed

Old mouse

Distance travelled at time of exhaustion

Running time to exhaustion

0% 100%

0% 100%

Mice today, independent elders tomorrow?

Distance travelled at time of exhaustion Time to exhaustion Speed

Old person 'with senescent cells removed'

Old person

Show me the money

Today there is little research funding on ageing relative to the scale of the problem or the potential rewards.

No UK charity now funds research into the biology of ageing. The British Society for Research on Ageing now seeks to do so.

Ageing is a global issue and so we are acting with AFAR and the Glenn Foundation. We welcome other partners.

UK disease costs vs. research spend

£11.0bn Cost of stroke £19.0bn Cost of dementia

£15.8bn Cost of cancer£23.7bn Cost of diabetes

£8.3bn All medical research

£0.02bn Biology of ageing research

Amount spent on US research

DiabetesCancer Parkinson's Dementia Visual impairment

Cardio-vascular

Osteoarthritis Ageing research

$364 $135 $125 $38 $35 $23 $12 $8

Per sufferer of disease

You get what you pay for

£715bn UK budget

£106bnNHS Spent on

people aged 65 and over

£10bnScience

£0.02bn Biology of ageing research

£42bn

What if we succeed? Lifespan Onset of ill health

Now

Compressed morbidity

Extended healthy lifespan

Nightmare scenario

Age 50 85

Improved healthspan had the largest impact on number of healthy older adults

Number of non-disabled people 65 and older in the US

90m

70

50

302010 2020 2030 2040 2050 2060

87.2m Improved healthspan

76.5m Delayed cancer

75.5m Medical care baseline 76.1m Delayed heart disease

26.6m Improved healthspan

32.0m Delayed cancer31.2m Delayed heart disease30.9m Medical care baseline

And it did so without increasing the number of disabled people

102010 2020 2030 2040 2050 2060

20

30m

Number of disabled people 65 and older in the US

A large benefit

There will be a large social benefit when we improve healthspan.

$8bn

$4bn

0

Improved healthspan Delayed cancer Delayed heart disease

$430bn $450bn-$470bn

$270bn

$7,110bn

$3,040bn

$4,070bndifference

Net cost

Benefit

43% of all the gold ever mined

29 years of clean drinking water globally

1.7% of total global wealth

The US alone could save $4 trillion if findings from ageing research were to be applied. That is the same as:

How much is $4 trillion?

Policy implications

Progress brings the promise of increased healthspan.

More than $7 trillion in social value awaits the US alone if we succeed.

Fiscal challenges are manageable.

“The only thing we have to fear is fear itself.” Franklin D. Roosevelt

No. We're offering you something better.

The chance to spend more of your life contented, useful and interesting to know.

Which is what everyone wants.

Are we offering immortality?

What should you do next?

Ask us the hard questions.

Tell us if you support us, tell us if you don't, but tell us why.

Enjoy the wine.