Circulated monthly to 26,000OphthalmologistsWorldwide

A European Outlookon the World ofOphthalmology

Circulation

Editorial

Features

Educational Supplements

ET Today - Congress Daily

EuroTimes Satellite Education Programme

Rates & Deadlines

Production

Contents

“I always look at it,every page”- Ophthalmologist, Slovenia

‘EuroTimes isregarded byophthalmologists asan essential read’( ASE Readership Survey)

EuroTimes is circulated monthly to over 25,000 ophthalmologists in over 150 countries worldwide. It is the leading ophthalmicmagazine published outside the United States and each of our readers receives a personally addressed copy 12 times a year.

EuroTimes is a monthly publication, which allows any advertisement placed to be circulated for a full calendar month. This isparticularly important to our advertisers as '3 or 4 ophthalmologists may share one copy of EuroTimes andtake turns to read it.' (ASE Readership Survey)

Our readers practice in a wide range of ophthalmic sub-specialties including glaucoma, cornea, retina and macular diseases. They relyon EuroTimes to keep them up-to-date on the ever evolving field of ophthalmology.

EuroTimes Regional circulation by geographical area (May 2005)

11

Circulation

Advertisers can reach atarget audience withregional distribution

Europe 19,749

Africa & the Middle East 2,021

Asia,Australia & New Zealand 2,791

North America 1,668

Central & South America 525

Editorial Advisory Board

Emanuel Rosen UK

Josep Güell Spain

Thomas Kohnen Germany

Michiel Luger The Netherlands

Olivia Serdarevic USA

Dimitrios Siganos Greece

Marie-José Tassignon Belgium

EuroTimes is a monthly magazine for ophthalmologists published by the European Society of Cataract & Refractive Surgeons (ESCRS,a non profit organisation).With a focus on the practice of ophthalmology in Europe, the magazine meets the demand for up-to-datetimely coverage of scientific congresses and events worldwide. Additional features include articles on personalities, travel, innovation& technology of interest to today’s busy ophthalmologist.The EuroTimes Editorial team is under the direction of Medical Editors ClivePeckar and Paul Rosen. In addition to our editors, leading ophthalmologists head the Editorial Advisory Board.

Editorial

Paul Rosen, UK

Medical Editors

Editorial Calendar Bonus Distribution

Clive Peckar, UK

22

January 10th Anniversary Issue

February Ensuring Patient Satisfactionafter Refractive Surgery

March MICS – The Future of Cataract Surgery?

April Keratoplasty Update

May Medical Therapy for Retinal Disease

June Diagnostic Imaging of the Eye

July New Paradigm: Innovations in Glaucoma Diagnosis and Treatment

November Presbyopia –Lens vs Lasers

December Global Ophthalmology

February 10th ESCRS Winter Refractive Surgery Meeting, Monte Carlo

World Ophthalmology Congress,Sao Paulo, Brazil

March ASCRS, San Francisco, CA

6th International Symposium on Ocular Pharmacology and

Therapeutics (ISOPT), Berlin, Germany

May EU Retina, Lisbon, Portugal

German Ophthalmic Surgeons Meeting,Nuremberg, Germany

June Asia Pacific Academy of Ophthalmology,Singapore

September XXIV Congress of ESCRS,London, UK

November American Academy of Ophthalmology,Las Vegas, USA

‘EuroTimes mainstrength wasperceived to lie inthe journalisticstyle ofpresentation’(ASE Readership Survey)

‘You read it to seewhat is happening,what’s new’- Ophthalmologist, Slovenia

33

Journal Watch Vision science highlights from the world’sleading journals of medicine and science

Prime Site Worldwide web for Ophthalmology

Eye on Travel Ideas and recommendations for destinations around the globe, often featuring cities that are soon to host major congresses

In Your Good Books Monthly review and synopsis of new texts available of interest to ophthalmologists

Bio Ophthalmology Basic Science for today’s ophthalmologist

Regulatory Matters A look at developments at EU level that effect the practice of medicine in Europe

Industry Briefs Recent Developments in the Vision Care Industry

Calendar of Events A comprehensive look at worldwide ophthalmic events for the year ahead

Features

Each issue of EuroTimes contains news and editorial on the latest developments and advances in the world of ophthalmology. Inaddition to this EuroTimes has a number of regular features that offers readers valuable up to date information & reviews on topicsof interest to today's ophthalmologist.

44

“Although it is easyreading, thecontent is stillprofessional”- Ophthalmologist, UK

Aside from advertising and sponsorship, EuroTimes also creates customised opportunities for our corporate partners.We offer avariety of educational tools to publicise your company’s developments and innovations, to our EuroTimes readers and beyond.

Print Supplements

Printed supplements provide Industry with an opportunity to expand the audience for their educational activities beyond the scopeof meetings and Congresses. Over the past years EuroTimes has worked with many companies to prepare supplements and insertsthat highlight new devices, therapies and procedures, and to communicate the company message to the EuroTimes reader. Our 2003Readership Survey found that EuroTimes readers were very appreciative of this form of communication and found it extremelyuseful to their practice.

Printed supplements and inserts can be developed from a wide range ofeducational activities including EuroTimes Satellite Education Symposia,Roundtables, and one-on-one interviews.

EuroTimes journalists can prepare supplements from material presented at anyESCRS Congresses or other ophthalmology meetings. In addition we can organiseturnkey stand-alone sessions and roundtables.These enduring materials providevaluable information to busy ophthalmologists and in addition to print format areavailable online at www.escrs.org.

In the past we have developed supplements on the follow topics:

� Next Step in IOL Revolution – Filtering Blue Light� Strategies in Cataract and Refractive Technology� The Initial Management of Glaucoma� Comprehensive Solutions in Refractive Surgery

Educational Supplements Language

Communication throughEnglish can still be a majorissue in Europe, especially

in Italy, Spain and manynew EU-Member

countries.

In order to address thesecultural differences, from

2006, printed supplementscan be translated into

selected Europeanlanguages and distributed

by country or region.

55

CD ROMsCD Roms can be produced for conference symposia to offer users the oppportunity to re-live the conference experience at theirown pace. This method of documenting symposia is particularly beneficial to ophthalmologists who do not have English as theirfirst language.

� A CD Rom of your symposium is mailed out with Eurotimes to over 25,000 ophthalmologists worldwide or, to a specific regionaltarget audience decided by the sponsor.

� Information can be accessed in an interactive manner and at the users own pace.

� Ophthalmologists will be able to easily pass on the information and message of your company on CD Rom to other colleagues.

Previous CD ROM titles that have been distributed with EuroTimes are:

� Standards in Cataracts and Refractive Technology- ESCRS Paris 2004

� Quality of Vision: Cataract and Refractive Live Surgery- ESCRS Munich 2003

66

For the duration of the ESCRS congress, our journalists are on hand to report on the activities taking place at the event and the latestnews from the industry. EuroTimes publishes ET Today a daily edition of EuroTimes for distribution each morning to congressdelegates. Advertising in ET Today is an excellent vehicle to attract visitors to your stand and advertise your products. A fullsponsorship option of an edition of ET Today is available.

ET Today contains articles and highlights of the ESCRS congress in a way that is interesting, informative and allows everyone involvedto reminisce about the congress. ET Today is often kept as a souvenir and taken home by delegates to share with their colleagueswho were unable to attend the meeting.

ET Today

Full Sponsorship of an issue of ETToday offers the following toadvertisers:

■ 4 out of 8 pages of the daily, dedicatedto your company's advertising oreditorial features.

■ Advertising space options include theoutside back and inside front covers.

■ Editorial coverage of your booth,products or symposia at the ESCRSannual congress.

■ Unrivalled coverage at the meetingthat will last beyond the event.

‘ESCRS EuroTimesmagazine is veryinteresting andcovers all fields ofophthalmology’- Ophthalmologist, Europe

77

EuroTimes Satellite Symposia are held in the Congress Centre outside the time of the main Scientific Programme. All Symposia aresponsored by Industry, and Scientific Programmes are agreed between the sponsor and EuroTimes. All EuroTimes Satellite Meetingsare approved for CME credit by the European Accreditation Council for Continuing Medical Education (EACCME).

Satellite Meeting Costs Include:

� Venue Rental

� Online Promotion and registration from ESCRS website

� Advertising in June, July and August issues of EuroTimes

� Audio Visual

� Onsite signage and registration facilities

� Programme information handout

� CME Accreditation and evaluation forms

� Lists of attendees with names and address details

� Opportunities for follow-up publication in EuroTimes

EuroTimes Satellite Education Programme

At the ESCRS Congress held inParis 2004, EuroTimes organised and

supported 10 successful SatelliteSymposia on behalf of our industrypartners.These symposia attracted

over 2000 delegates in total and covered a wide variety of

subject matter.

‘I can read aboutall the recentimprovements inophthalmology inESCRS EuroTimesmagazine on amonthly basis.Thanks you..’- Ophthalmologist, Middle East

88

‘Ads that areperceived to beinformative/usefulare cut out or usedto take notes.’( ASE Readership Survey)

Rates & Deadlines

Frequency Full pg Full pg 3/4 pg 1/2 pg 1/2 pg 1/3 pg 1/4 pg 1/4 pgSpread Spread Spread

1 11,128 5,564 4,173 6,255 3,055 2,006 2,140 1,241

6 10,935 5,500 4,125 6,211 3,001 1,958 2,119 1,198

12 10,796 5,446 4,082 6,040 2,943 1,905 2,087 1,161

18 10,540 5,404 4,045 5,992 2,878 1,851 2,054 1,136

24 10,272 5,318 4,007 5,955 2,825 1,798 2,033 1,107

36 10,144 5,216 3,970 5,912 2,766 1,749 2,006 1,070

48 10,020 5,141 3,916 5,869 2,643 1,696 1,963 1,038

Deadlines

Space Booking Artwork

January 15th Nov 2005 1st Dec 2005

February 15th December 2005 1st January 2006

March 15th January 2006 1st February 2006

April 15th February 2006 1st March 2006

May 15th March 2006 1st April 2006

June 15th April 2006 1st May 2006

July 15th May 2006 1st June 2006

August 15th June 2006 1st July 2006

September 15th July 2006 1st August 2006

October 15th August 2006 1st September 2006

November 15th September 2006 1st October 2006

December 15th October 2006 1st November 2006

Agency Commission10% commission on earned black and white rate pluscolour charges

InsertsAdvertiser supplied inserts from 2 to 4 pages areaccepted. A paper and insert sample must besubmitted to the publisher for approval. Quotesavailable from advertising office on custom printedinserts.

Cost of Inserts

2 page - 2 x earned black and white rate for 1/2 pgisland adverts plus E1,255.00

4 page - 4 x earned black and white rate for 1/2 pgisland adverts plus E1,255.00

Business Reply Cards1 x earned black and white rate for applicable sizeplus E1,160.00 for gummed insertion

Premium Positions

Inside Front Cover:Earned B&W rate plus 25%

Inside Back Cover:Earned B&W rate plus 15%

Outside Back Cover:Earned B&W rate plus 40%

Colour Charges

Full Colour / 4 Colour e1,950 in addition to black andwhite earned rates

Enhance your boothposition at the ESCRSAnnual Congresses byaccumulating prioritypoints in conjunction

with all marketingopportunities detailed in

this media guide.

Every e spent withESCRS & EuroTimesearns a priority pointwhich can be used to

determine yourpreferred booth location

at the ESCRSCongresses.

■ All prices quoted are in e Effective 2006

Priority Points

99

‘Some of the adsI’ve clipped outbefore.You seesomething that youmight want, so theydo their job verywell… I like to lookat these because Ilike to know theway things aregoing.’- Ophthalmologist, Switzerland

Production

Full pg270 x 320mm+5mm bleed

Full pg Spread540 x 320mm+5mm bleed

1/2 pg Spread300 x 230mm

1/4 pg Island Spread310 x 95mm

1/2 pgvertical

140 x 230mm

1/3 pg95 x 210mm

1/4 pgvertical

95 x 140mm

1/4 pghorizontal

strip250 x 50mm

1/4 pgvertical

strip45 x 295mm

1/4 pghorizontal150 x 95mm

1/2 pghorizontal250 x 140mm

Production Requirements

� EuroTimes is a full colour production throughout.

� We accept four colour process ads, (CMYK) or B/W.

� You must provide a valid colour proof with the ad, if you do not provide us with a valid proof, we cannot be responsible for any inconsistencies.

� We can accept ads on CD, by Email or from FTP sites, provided the files are high resolution PDFs only.

� All fonts must be embedded.

� Allow 5mm for all sides that bleed (Full page ads only)

If we detect an error with your PDF before going to press (usually non-embedded fonts), we will make everyreasonable effort to contact you so that you may correct and resubmit your PDF before publication.However, if we have to use the failed PDF you have provided, we will render, save and use it as an .EPS or.TIFF file.This process may result in some loss of quality for which the Publisher accepts no responsibility.

For more details on any of theopportunities featured and to request an

insertion form, please contact

Caroline FitzpatrickAdvertising Manager

Telephone: +353 1 209 1100Fax: +353 1 209 1122

Email: caroline.fitzpatrick@agenda-comm.ie

Sizes stated are actual size of ads to be supplied.

European Society of Cataract & Refractive SurgeonsTemple House, Temple Road, Blackrock, Co. Dublin, Ireland

Tel: + 353 1 209 1100 Fax: + 353 1 209 1112 Email: eurotimes@escrs.org

Web: www.escrs.org