a family of matched parent-child hla haplotypes: a case study … · 2020-06-21 · a family of...
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![Page 1: A family of matched parent-child HLA haplotypes: A case study … · 2020-06-21 · A family of matched parent-child HLA haplotypes: A case study from Bahrain Mariam Fida, MD, PhD](https://reader036.vdocuments.net/reader036/viewer/2022070918/5fb85829d35a631abb44bcc8/html5/thumbnails/1.jpg)
A family of matched parent-child HLA haplotypes:
A case study from Bahrain
Mariam Fida, MD, PhD Director | PGD
Consultant| Medical Genetics
GCC Forensics Conference & Exhibition 14.Nov.2019
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HLA Typing
Match patient & donors for bone marrow, cord blood or organ transplants
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HLA Complex
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HLA Typing
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Relatives of patient
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Relatives of patient
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Relatives of patient
100% match
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Human Identification Test
Mother
Son
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Human Identification Test
Mother
Son
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Consanguinity
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Extended family pedigree
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Family Haplotypes
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Conclusion
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Sickle Cell Carrier
Sickle Cell Affected
Sickle Cell Disease
Sickle Cell Carrier
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PGT
Hemophilia
Sickle Cell Disease
Colon Cancer
Breast Cancer
SCID
↓G6PD
Phynelketonuria
α-Thalassemia
β-Thalassemia
Cystic Fibrosis
Down Syndrome
Fragile X Spinal Muscular Atrophy
Polycystic Kidney Disease
A test performed to analyze the DNA from oocytes or embryos for HLA-typing or for determining genetic abnormalities
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Sickle Cell Carrier
Sickle Cell Affected
Sickle Cell Disease
Sickle Cell Carrier
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Sickle Cell Carrier
Sickle Cell Affected
Sickle Cell Disease
Sickle Cell Carrier
Healthy unaffected
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Sickle Cell Carrier
Sickle Cell Affected
Sickle Cell Disease
Sickle Cell Carrier
Healthy unaffected
HLA match to affected sibling
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IVF
PGT
PGT - M
(day 3)
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IVF
PGT
PGT - M
(day 3)
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IVF
PGT
PGT - M
(day 3)
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IVF
PGT
PGT - M
(day 3)
Transfer into mother
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Acknowledgment
Ryan Ed Bangate
Ferdinand Webnda
Arnold A. Villanueva
PGT Team
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Thank you!