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A Member of Mennen Medical Group MTRE Advanced Technologies Medical Thermo Regulation Expertise A Member of Mennen Medical Group July 2010

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A Member of Mennen Medical Group

MTRE Advanced Technologies

Medical Thermo Regulation Expertise

A Member of Mennen Medical Group

July 2010

A Member of Mennen Medical Group

• An Integrated Patient Monitoring and Temperature Management System

• Combines the advantages of CritiCool with Mennen Medical’s VitaLogik Patient Monitor

A Member of Mennen Medical Group

A Member of Mennen Medical Group

• Whole body, Non invasive Servo control cooling therapy offers fast and precise cooling to target temperature, using the CureWrapTM – a flexible, three dimensional heat exchange garment.

A Member of Mennen Medical Group

Cooling with care, Monitor the Beat

A Member of Mennen Medical GroupA Member of Mennen Medical Group

Cool Fast

• For Use on Adults or Infants• High heat exchange by 3-dimensional body coverage with _______

_, maximizes energy transfer and provides effective induction and maintenance of mild hypothermia

• Precise control of patient core temperature using the temperature control algorithm

• Continuous temperature feedback enables Automatic temperature control throughout treatment

• Reduces staff time and labor • Convenient and easy to use• Patient cooling is achieved in three simple steps:

Simply Set, wrap & Cool

A Member of Mennen Medical Group

• Re-warm - Automatically Controlled and Gradual • Controlled re-warming with CritiCool pro significantly reduces the

rebound increase in intracranial pressure, CritiCool pro actively controls the process of re-warming and achieves a gradual increase in temperature

A Member of Mennen Medical Group

Cool Fast, Re-warm Slow

Re-Warming

Cooling and Automatic Re-warming at 33.5-36.5°C for 82.3 hours

A Member of Mennen Medical Group

• Adult / Neonatal Mode• ECG and Heart Rate• ST Segment Analysis• Full Range of Arrhythmias• Respiration• SpO2• NIBP• Temperature Regulation

The monitoring capability has an extensive storagecapability of Full Disclosure, charts, trends and event strips. Alarms with status messages of all the vital signs parameters can beconfigured to the needs of the patient’s clinical condition.

A Member of Mennen Medical Group

Vital Signs Parameters and Waveforms On a 12.1”TFT Display Monitor

A Member of Mennen Medical GroupA Member of Mennen Medical Group

Displayed Temperature Regulation Parameters - Cooling

Cooling Adult / Neonatal

Set Point temp for cooling mode

Cooling binary state

33.5°C

Core Temperature OC / OF

Surface Temperature OC / OF

A Member of Mennen Medical GroupA Member of Mennen Medical Group

Displayed Temperature Regulation Parameters - Re Warming

Adult Re-Warm rate

Target temp for re-warming mode

Heating binary state

Core Temperature OC / OF

Surface Temperature OC / OF

A Member of Mennen Medical Group

Simply Set ,Wrap & Cool

• One piece, body shaped garment that facilitates wrapping of your patient.

• Maximize surface coverage to ensure optimal energy transfer.• Simultaneous water flow through numerous channels provides

superior heat exchange capacity.• Bio-compatible, latex free and anti static that suits any hospital

setting.• Secured onto your patient using pre-attached hook & loop

(Velcro) strips, it allows easy and intuitive access to your patient.

• Permits 72h treatment.

A Member of Mennen Medical GroupA Member of Mennen Medical Group

Cooling with CritiCool proClinical studies show that Cooling improves Neurological

Outcome in many indications:

• ROSC after Cardiac Arrest: Hypothermia has become routine practice in medical centers worldwide in patients with Return of Spontaneous Circulation after VF or Pulseless VT

• Stroke: A decrease of brain temperature reduces ischemic brain injury, brain edema and intracranial pressure (ICP)

• Traumatic Brain Injury (TBI): hypothermia has been shown to improve patient outcome by reducing ICP and limiting secondary brain injury after severe head trauma

• Asphyxia and Hypoxic Ischemic Encephalopathy: Cooling therapy can significantly improve neurological outcomes of newborns with Hypoxic-Ischemic Encephalopathy (HIE)

• Uncontrolled Hypothermia: Fever in critically ill patients, mainly neurointensive care unit patients

A Member of Mennen Medical GroupA Member of Mennen Medical Group

The Need for Therapeutic Hypothermia

A Member of Mennen Medical Group

The Need for Therapeutic Hypothermia

In 2002, two randomized controlled trials published in the NEJM, prove that therapeutic hypothermia (reduction of temperature to 32-34°C) after cardiac arrest

• Improves neurologic & functional outcome• Reduces mortality

A Member of Mennen Medical Group

ILCOR Recommendations

The ALS task force of the International Liaison committee on resuscitation (ILCOR) made the following recommendation in 2002:• “Unconscious adult patients with spontaneous circulation after out-of-

hospital cardiac arrest should be cooled to 32°C to 34°C for 12 to 24 hours when the initial rhythm was VF.

• Such cooling may also be beneficial for other rhythms or in-hospital cardiac arrest”.

A Member of Mennen Medical Group

A Member of Mennen Medical Group

Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy

TOBY study Group, NEJM 2009

• Apgar score of 5 or less or a continued need for resuscitation or, acidosis within 60 minutes after birth

• Moderate-to-severe encephalopathy, an absent or weak suck, or clinical seizures.

• Abnormal background activity of at least 30 minutes’ duration or seizures on amplitude integrated electroencephalography

• Results: No significant reduction in the combined rates of death and severe disability with cooling, as compared with no cooling, but a significant improvement in several secondary neurologic outcomes among survivors

In this randomized, control study comparing intensive care plus total-body cooling for 72 hours with intensive care without cooling, Neonates with the following signs and symptoms were included:

A Member of Mennen Medical Group

Temperature control saves lives

A Member of Mennen Medical Group

Contact details

Our address: 4 Hayarden St. YavneP.O Box 102 Rehovot, 76100, Israel

Tel: +972-8-9323333Fax: +972-8-9328510

Visit our website: www.mtre.com

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