a multiscale model for the simulation of cerebral and … · qtot q qex qvv qjl1 qjr1 qjl2 qjr2...
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![Page 1: A multiscale model for the simulation of cerebral and … · Qtot Q Qex Qvv Qjl1 Qjr1 Qjl2 Qjr2 Qjl3 Qjr3 Qvp Qejl Qejr Qvs Qdcv] Adult simulation Pediatric MRI data Pediatric simulation](https://reader031.vdocuments.net/reader031/viewer/2022013023/5fc7fdc1f6887426bd7d82c2/html5/thumbnails/1.jpg)
Dott. Giacomo Gadda
31-05-2019
A multiscale model for the
simulation of cerebral and extracerebral
blood flows and pressures in humans
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Model features
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Model features
• POSTURE
![Page 4: A multiscale model for the simulation of cerebral and … · Qtot Q Qex Qvv Qjl1 Qjr1 Qjl2 Qjr2 Qjl3 Qjr3 Qvp Qejl Qejr Qvs Qdcv] Adult simulation Pediatric MRI data Pediatric simulation](https://reader031.vdocuments.net/reader031/viewer/2022013023/5fc7fdc1f6887426bd7d82c2/html5/thumbnails/4.jpg)
Model features
• POSTURE
• STENOSIS
![Page 5: A multiscale model for the simulation of cerebral and … · Qtot Q Qex Qvv Qjl1 Qjr1 Qjl2 Qjr2 Qjl3 Qjr3 Qvp Qejl Qejr Qvs Qdcv] Adult simulation Pediatric MRI data Pediatric simulation](https://reader031.vdocuments.net/reader031/viewer/2022013023/5fc7fdc1f6887426bd7d82c2/html5/thumbnails/5.jpg)
Model features
• POSTURE
• BREATHING
• STENOSIS
![Page 6: A multiscale model for the simulation of cerebral and … · Qtot Q Qex Qvv Qjl1 Qjr1 Qjl2 Qjr2 Qjl3 Qjr3 Qvp Qejl Qejr Qvs Qdcv] Adult simulation Pediatric MRI data Pediatric simulation](https://reader031.vdocuments.net/reader031/viewer/2022013023/5fc7fdc1f6887426bd7d82c2/html5/thumbnails/6.jpg)
Model features
• POSTURE
• BREATHING
• STENOSIS
• PaCO2 PRESSURE
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Scheme of the model
Gadda et al. AM J Physiol – 2015 Gadda et al. Conf Proc IEEE – 2015
Gadda et al. AJNR – 2016 Gadda et al. Conf Proc RTSI – 2016Gadda et al. Eur J Appl Physiol – 2018
EXTRACRANIAL
ARTERIES EXTRACRANIAL
VEINS
BRAINCASE
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Work at the MRI Institute (Detroit, USA)Posture modelling
𝐺𝑥 = 𝑘𝑥 1 +2
πtan−1
𝑃𝑥 𝑖𝑛𝑡 − 𝑃𝑥 𝑒𝑥𝑡𝐴
2
Gadda et al. AM J Physiol – 2015
![Page 9: A multiscale model for the simulation of cerebral and … · Qtot Q Qex Qvv Qjl1 Qjr1 Qjl2 Qjr2 Qjl3 Qjr3 Qvp Qejl Qejr Qvs Qdcv] Adult simulation Pediatric MRI data Pediatric simulation](https://reader031.vdocuments.net/reader031/viewer/2022013023/5fc7fdc1f6887426bd7d82c2/html5/thumbnails/9.jpg)
Work at the MRI Institute (Detroit, USA)Posture modelling
US supine upright variation
Qj3 6.0±2.6 4.1±2.0 -32%
Qj2 8.9±3.4 5.2±3.3 -42%
Qj1 22.0±10.3 20.4±12.5 -7%
Qvv 1.1±0.7 2.3±1.2 +109%
Every flow 𝑄𝑥 is reported in ml/s
Gadda et al. AJNR 2016
𝐺𝑥 = 𝑘𝑥 1 +2
πtan−1
𝑃𝑥 𝑖𝑛𝑡 − 𝑃𝑥 𝑒𝑥𝑡𝐴
2
![Page 10: A multiscale model for the simulation of cerebral and … · Qtot Q Qex Qvv Qjl1 Qjr1 Qjl2 Qjr2 Qjl3 Qjr3 Qvp Qejl Qejr Qvs Qdcv] Adult simulation Pediatric MRI data Pediatric simulation](https://reader031.vdocuments.net/reader031/viewer/2022013023/5fc7fdc1f6887426bd7d82c2/html5/thumbnails/10.jpg)
Work at the MRI Institute (Detroit, USA)Stenosis modelling
Gadda et al. AJNR 2016
![Page 11: A multiscale model for the simulation of cerebral and … · Qtot Q Qex Qvv Qjl1 Qjr1 Qjl2 Qjr2 Qjl3 Qjr3 Qvp Qejl Qejr Qvs Qdcv] Adult simulation Pediatric MRI data Pediatric simulation](https://reader031.vdocuments.net/reader031/viewer/2022013023/5fc7fdc1f6887426bd7d82c2/html5/thumbnails/11.jpg)
Work at the MRI Institute (Detroit, USA)Stenosis modelling
Gadda et al. AJNR 2016
![Page 12: A multiscale model for the simulation of cerebral and … · Qtot Q Qex Qvv Qjl1 Qjr1 Qjl2 Qjr2 Qjl3 Qjr3 Qvp Qejl Qejr Qvs Qdcv] Adult simulation Pediatric MRI data Pediatric simulation](https://reader031.vdocuments.net/reader031/viewer/2022013023/5fc7fdc1f6887426bd7d82c2/html5/thumbnails/12.jpg)
Work at the MRI Institute (Detroit, USA)Pressure modelling
Gadda et al. Eur J Appl Physiol 2018
![Page 13: A multiscale model for the simulation of cerebral and … · Qtot Q Qex Qvv Qjl1 Qjr1 Qjl2 Qjr2 Qjl3 Qjr3 Qvp Qejl Qejr Qvs Qdcv] Adult simulation Pediatric MRI data Pediatric simulation](https://reader031.vdocuments.net/reader031/viewer/2022013023/5fc7fdc1f6887426bd7d82c2/html5/thumbnails/13.jpg)
Work at the MRI Institute (Detroit, USA)Pressure modelling
Gadda et al. Eur J Appl Physiol 2018
![Page 14: A multiscale model for the simulation of cerebral and … · Qtot Q Qex Qvv Qjl1 Qjr1 Qjl2 Qjr2 Qjl3 Qjr3 Qvp Qejl Qejr Qvs Qdcv] Adult simulation Pediatric MRI data Pediatric simulation](https://reader031.vdocuments.net/reader031/viewer/2022013023/5fc7fdc1f6887426bd7d82c2/html5/thumbnails/14.jpg)
Work at the MRI Institute (Detroit, USA)Pressure modelling
Gadda et al. Eur J Appl Physiol 2018
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Model features
• POSTURE
• BREATHING
• STENOSIS
• PaCO2 pressure
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Model features
• POSTURE
• BREATHING
• STENOSIS
• PaCO2 pressure
• AGING
• MICROGRAVITY
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Qtot Q Qex Qvv Qjl1 Qjr1 Qjl2 Qjr2 Qjl3 Qjr3 Qvp Qejl Qejr Qvs Qdcv
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Adult simulation
Pediatric MRI data
Pediatric
simulation
Future developments
![Page 18: A multiscale model for the simulation of cerebral and … · Qtot Q Qex Qvv Qjl1 Qjr1 Qjl2 Qjr2 Qjl3 Qjr3 Qvp Qejl Qejr Qvs Qdcv] Adult simulation Pediatric MRI data Pediatric simulation](https://reader031.vdocuments.net/reader031/viewer/2022013023/5fc7fdc1f6887426bd7d82c2/html5/thumbnails/18.jpg)
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Qtot Q Qex Qvv Qjl1 Qjr1 Qjl2 Qjr2 Qjl3 Qjr3 Qvp Qejl Qejr Qvs Qdcv
Flo
w [
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Adult simulation
Pediatric MRI data
Pediatric
simulation
Future developments
Taibi et al. Sens Actuators A Phys 2018 Taibi et al. Physiol Meas 2017
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Thanks for your attention
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Aging modelling