New Treatments in Chronic

Liver Disease

Endorsed By

More than 40 national CME conferences, in over 15 specialty areasScripps Conference Services & CME • www.scripps.org/conferenceservices

Hyatt Regency La Jolla at AventineSan Diego, California

March 26-27, 2011

26Th

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Randolph Schaffer, MDScripps Clinic Division of Organ and Cell Transplantation La Jolla, California Jill Lane, MD Division of Gastroenterology Scripps Clinic La Jolla, California Andrea Scherschel, NP Division of Gastroenterology/ Hepatology Scripps Clinic La Jolla, California

Albert Czaja, MD, fACP, fACG, AGAf, Professor of Medicine Emeritus Mayo Clinic College of Medicine Rochester, Minnesota Douglas Dieterich, MD, fACG

Professor of MedicineDivision of Liver DiseasesDirector of Continuing Medical Education, Department of MedicineMount Sinai School of MedicineNew York, New York Stephen harrison, MDChief of HepatologyBrooke Army Medical CenterSan Antonio, Texas

Tarek hassanein, MD, fACP, fACG, AGAfMedical DirectorSouthern California Liver CentersDivision of Organ and Cell TransplantationScripps ClinicCoronado, California

Paul Martin, MD, fACP, fACGProfessor of MedicineChief, Division of HepatologyUniversity of MiamiLeonard M. Miller Schoolof MedicineMiami, Florida

Norman Sussman, MDAssociate Professor, Liver CenterBaylor College of MedicineHouston, Texas

William S. haubrich, MD

Dr. Haubrich graduated from Franklin & Marshall College in Lancaster, Pennsylvania in 1943 and from the medical school of Case-Western Reserve University in Cleveland, Ohio in 1947. His postgraduate training in pathology and internal medicine was at Cleveland City Hospital (now MetroHealth). His mentor in gastroenterology was Dr. Henry L. Bockus at the Graduate Hospital of the University of Pennsylvania in Philadelphia.

During the Korean War he served as gastroenterologist to the Madigan Army Hospital at Fort Lewis, Washington. From 1955 to 1970 he was on the gastroenterology staff at the Henry Ford Hospital in Detroit. In 1970 he was appointed Clinical Member

at the Scripps Clinic and Research Foundation where he headed the division of gastro-enterology from 1972 to 1984.

He has served as Clinical Professor of Medicine at the University of California, San Di-ego since 1971. His scholarly contributions include more than 200 journal articles and textbook chapters. He was consultant in life sciences to the editors of the 3rd and 4th editions of the American Heritage Dictionary of the English Language. In 1960 he was awarded the Vincent Lyon Prize by the American Gastroenterology Association and in 1985 received the Rudolf Schindler Award of the American Society of Gastrointestinal Endoscopy. He has been named a Master of the American College of Physicians.

t h e w i l l i a m s . h a u b r i c h d i s t i n g u i s h e d l e c t u r e r

William S. Haubrich, M.D.Dr. Haubrich graduated from Franklin & Marshall College in Lancaster, Pennsylvania in 1943 and from the medical school of Case-Western Reserve University in Cleveland, Ohio in 1947. His postgraduate training in pathol-ogy and internal medicine was at Cleveland City Hospital (now MetroHealth). His mentor in gastroenterology was Dr. Henry L. Bockus at the Graduate Hospital of the University of

Pennsylvania in Philadelphia.

During the Korean War he served as gastroenterologist to the Madigan Army Hospital at Fort Lewis, Washington. From 1955 to 1970 he was on the gastroenterology staff at the Henry Ford Hospital in Detroit. In 1970 he was appointed Clinical Member at the Scripps Clinic and Research Foundation where he headed the division of gastroenterology from 1972 to 1984.

He has served as Clinical Professor of Medicine at the University of California, San Diego since 1971. His scholarly contributions include more than 200 journal articles and textbook chapters. He was consultant in life sciences to the editors of the 3rd and 4th editions of the American Heritage Dictionary of the English Language. In 1960 he was awarded the Vincent Lyon Prize by the American Gastroenterology Association and in 1985 received the Rudolf Schindler Award of the American Society of Gastrointestinal Endoscopy. He has been named a Master of the American College of Physicians.

Willis C. Maddrey, M.D.Willis C. Maddrey, MD, is Professor of Internal Medicine and Executive Vice President for Clinical Affairs at The University of Texas Southwestern Medical Center at Dallas. Dr. Maddrey received his medical degree from The Johns Hopkins University School of Medicine in Baltimore, Maryland, and com-pleted his residency on the Osler Medical

Service of The Johns Hopkins Hospital. He was Chief Medical Resident in 1969. Additional postgraduate work includes a fellowship in liver disease with Dr. Gerald Klatskin at Yale University School of Medicine.

From 1970 to 1981, Dr. Maddrey directed the liver unit at The Johns Hopkins University School of Medicine where he was Professor of Medicine and Associate Physician in Chief. From 1982 to 1990, he was Magee Professor and Chairman of the Department of Medicine at Jefferson Medical College.

Dr. Maddrey has authored numerous scientific publications. He has published extensively in the areas of chronic viral hepatitis, drug-induced liver disease, alcohol-induced liver disease, liver transplantation, and primary biliary cirrhosis. He has authored numerous publications focusing on hepatitis and liver disease. He has edited or co-edited nine books including Transplantation of the Liver, which is now in its third edition, and Schiff's Diseases of the Liver, the ninth edition of which was published in November, 2002.

c o u r s e d i r e c t o r

Paul J. Pockros, M.D., F.A.C.P., F.A.C.G.Head, Division of Gastroenterology/HepatologyCo-Director, Liver Disease CenterScripps ClinicDirector, SC Liver Research ConsortiumLa Jolla, California

g u e s t f a c u l t y

Adrian M. Di Bisceglie, M.D., F.A.C.P.Professor of Internal MedicineActing ChairmanSaint Louis University School of MedicineSt. Louis, Missouri

Edward Krawitt, M.D., F.A.C.G.Adjunct Professor of MedicineDartmouth CollegeProfessor of MedicineUniversity of VermontBurlington, Vermont

Willis C. Maddrey, M.D., M.A.C.G.Professor of Internal MedicineUT Southwestern Medical CenterDallas, Texas

Paul Martin, M.D., F.A.C.G.Professor of Medicine, Liver DiseasesProfessor of SurgeryMt. Sinai School of MedicineNew York, New York

Norman L. Sussman, M.D.Associate Professor of Surgery and MedicineBaylor College of MedicineHouston, Texas

Zobair M. Younossi, M.D., M.P.H.Executive Director, Center for Liver Diseases at Inova Fairfax HospitalExecutive Director of Research, Inova Health SystemProfessor of Medicine, VCU – Inova CampusAnnandale, Virginia

s c r i p p s f a c u l t y

Donald J. Hillebrand, M.D.Medical Director, Liver TransplantationDivision of Gastroenterology/HepatologyScripps ClinicLa Jolla, California

Jill A. Lane, M.D.Division of Gastroenterology/HepatologyScripps ClinicLa Jolla, California

Faculty

Hilton La Jolla Torrey Pines San Diego, California

Hyatt Regency La Jolla at AventineSan Diego, California

March 26-27, 2011

faculty Disclosure In accordance with the ACCME Standards for Commercial Support, course directors, planning committees, faculty and all others in control of the educational content of the CME activity must disclose all relevant financial relationships with any commercial interest that they or their spouse/partner may have had within the past 12 months. If an individual refuses to disclose relevant financial relationships, they will be disqualified from being a part of the planning and implementation of this CME activity. Employees of a commercial interest with business lines or products relating to the content of the CME activity will not participate in the planning or any accredited portion of the conference. Disclosure will be made to all participants at the conference location, prior to the educational activity commencement.

T h E W I L L I A M S . h A u B R I C h D I S T I N G u I S h E D L E C T u R E R

Jill Chang, PA-C Division of Gastroenterology/Hepatology Scripps Clinic La Jolla, California Miguel Goicoechea, MD Division of Infectious Diseases Scripps Clinic La Jolla, California Donald hillebrand, MD Medical Director, Liver Transplantation Division of Gastroenterology Division of Organ and Cell Transplantation Scripps Clinic La Jolla, California

Course Director Paul Pockros, MD, fACP, fACG

Head, Division of Gastroenterology/HepatologyDirector, Liver Disease CenterScripps ClinicDirector, SC Liver Research ConsortiumLa Jolla, California

Faculty

hyatt Regency La Jolla at Aventine 3777 La Jolla Village DriveSan Diego, CA 92122 Reservations: 800-233-1234 hotel Direct: 858-552-1234 Web: hyattregencylajolla.com

Only a few miles from downtown San Diego and minutes away from down-town La Jolla, the unique Hyatt Regency La Jolla at Aventine is defined by the dichotomy that is this town – the quaint charm of a European village mingled with the energetic high style you’d expect from Southern Califor-nia. Embark upon self-renewal within the luxurious spa, enjoy the expansive 32,000 square foot Sporting Club - that includes a regulation basketball court and two lighted tennis courts – dive into the Olympic-style pool or relax in the whirlpool surrounded by private cabanas. Situated on 11 acres, the lush grounds also offer the perfect setting for a jog or hike. When you’re ready to explore the area, the knowledgeable concierge is on hand to assist you with planning of your itinerary to make the most of your stay at this Four-Diamond La Jolla California hotel.

DiningEither located within the hotel or directly across from the front entrance, the Hyatt Regency La Jolla at Aventine offers many dining options:

Rates & ReservationsPlease make your own reservations and mention the Scripps Liver Disease Conference to receive the reduced rate of $175 per night (excludes tax). Make your reservations early! A block of rooms will be held for Scripps until March 11, 2011. After this date, reservations will be accepted on a space and rate available basis only.

All Scripps discounted rooms come with: • Complimentary wired internet in guest rooms • Discounted self-parking

Albert Czaja, MD, fACG, AGAf, fACP

Albert J. Czaja, MD is emeritus professor of medicine at the Mayo Clinic College of Medicine, Rochester, Minnesota. He graduated from Dartmouth College in 1965, and Harvard Medi-cal School in 1968. He was trained in internal medicine at the Philadelphia General Hospital, University of Pennsylvania Divi-sion, from 1968-1972. As a major in the United States Army Medical Corps from 1972-1975, Dr. Czaja was stationed at the United States Army Institute of Surgical Research at Fort Sam Houston in San Antonio, Texas. It was here that he performed key studies on the prevalence, patho-physiology and treatment of burn-related (Curling’s) gastric and duodenal ulcers. Dr. Cza-

ja was an NIH Research Fellow in hepatology at the Mayo Clinic under the mentorship of W.H.J. Summerskill, MD from 1975-1977, and he joined the staff of the Mayo Clinic Division of Gastroenterology and Hepatology in 1977 where he was appointed professor of medicine in 1986.

His research has focused on chronic hepatitis, especially autoimmune hepatitis. Dr. Czaja received the AGA Fiterman Award for distinguished clinical investigation in hepatology in 1997, the Henry S. Plummer Distinguished Physician Award by the Mayo Clinic Depart-ment of Medicine in 2006, the Distinguished Clinician Award of the AGA in 2007, and the Distinguished Clinician Educator Award (1st recipient) of the AASLD in 2008. Dr. Czaja was a founding member of the International Autoimmune Hepatitis Group in 1992.

Conference Location

• Barcino Grill – California cuisine• Café Japengo – Sushi/Pacific Rim cuisine• Fleming’s Prime Steakhouse

• Michael’s Lounge• The Melting Pot – Foundue• Truluck’s – Seafood, Steak & Crab House

Guest facultyScripps faculty

Course IntroductionCourse overview

This CME conference will review new medications and therapies that are available, or will soon be available, and discuss their comparative values. The results of trials using new drugs to treat chronic viral hepatitis B and C, non-alcoholic fatty liver diseases, autoimmune hepatitis, primary biliary cirrhosis, hepatocellular carcinoma and complications of end-stage liver disease will be reviewed in detail. New Treatments in Chronic Liver Disease is a comprehen-sive yet concise program for updating physicians on these and other commonly encountered problems in the treatment of liver diseases.

There will be a fundamental change in treatment of chronic renal hepatitis C in 2011 with the addition of direct-acting antiviral (DAAs) drugs to current standard of care. There will be two separate lectures devoted to this topic this year. The first will be on triple therapies which will be approved in 2011. The second will be on combination therapies using two or more DAA’s.

We anticipate that there will be a number of demands placed on treatment providers which will be new, including different pretreatment predictors, viral resistance monitoring, rash and anemia management, and learning different therapeutic regimens. Looking beyond 2011, we see numerous combinations of DAA’s in development including protease inhibitors, nucleoside polymerase inhibitors, non-nucleoside polymerase inhibitors and N55A inhibitors. All of these agents are entering phase 3 development rapidly. In hepatitis B, the treatments have not changed but there are more mature data available on viral resistance, long-term HBsAg loss and clinical outcomes. The explosive growth of NASH in the US has created a significant need for effective drug therapy. New therapies for NAFLD and NASH are in development and will be explored. The diagnosis and treatment of hepatocellular carcinoma will be updated as this disease is one of the few cancers with a growing incidence in the US. New oral therapy is moving this field forward. There will be an update on non-malignant hepatic tumors and their management as these are com-monly seen in practice.

Educational objectives

After participating in this course, attendees should be able to:• Review our current knowledge of NAFLD and non-alcoholic steatohepatitis and explore the use of new agents and approaches to treatment of the conditions. • Integrate the algorithm for a therapeutic approach to treatment of HBV using new drugs. • Discuss novel therapies for HCV including NSSA, protease and polymerase inhibitors. • Update the skills and management required for transplant hepatology. • Apply current options of therapy for hepatocellular carcinoma to determine the best approach for your patients. • Discuss new treatment paradigms for HCV direct-acting antiviral drugs. • Recognizing the impact of NAFLD and NASH in the US and consider new treatment options for these patients. • Describe the diagnosis and treatment of autoimmune hepatitis. • Integrate treatment options discussed for patients with ESLD due to alcohol who have complicating factors such as HCV, NASH or inherited genetic disorder. • Discuss the issues complicating drug treatment in decompensated hepatic C, hepatic encephalopathy and acute alcoholic hepatitis. • Review the management of non-malignant hepatic tumors.

AccreditationScripps Health is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Scripps Health designates this live activity for a maximum number of 9.75 AMA PRA Category 1 Credit(s)™. Physicians should only claim creditcommensurate with the extent of their participation in the activity.

Documentation of awarded credit is provided for registered attendees in exchange for completed activity evaluation. Certificates of attendance are available, upon request, at the end of the course.

Nurses: The California State Board of Registered Nurses (BRN)accepts AMA PRA Category 1 Credit(s)™ as meeting continuing educationrequirements for license renewal. Most state Boards of Registered Nurses accept AMA PRA Category 1 Credit(s)™ as meeting continuing educationrequirements for license renewal. Nurses should check with their state board regarding use of CME credit.

Nurse Practitioners: This program will be submitted to the AmericanAcademy of Nurse Practitioners for continuing education credit.

Physicians Assistants: The American Academy of Physician Assistants ac-cepts Category 1 credit from AMA Category 1 CME organizations accredited by ACCME.

Pharmacists: This conference meets CE Standards for Pharmacists by the California State Board of Pharmacy.

Educational GrantsThis course is supported, in part, by educational grants from industry, in accordance with ACCME accreditation Standards for Commercial Support. At the time of printing, a complete listing of commercial supporters was not available. Appropriate acknowledgement will be given to all supporters at the time of the educational activity.

Cultural and Linguistic CompetencyThis activity is in compliance with California Assembly Bill 1195 which requires that all CME activities comprising a patient care element include curriculum addressing the topic of cultural and linguistic competency. The intent of this bill is to ensure that health care professionals are able to meet the cultural and linguistic concerns of a diverse patient population through effective and appropriate profes-sional development. Cultural and linguistic competency was incorporated into the planning of this activity.

Accreditation & Disclosure

HepatologistsGastroenterologists

Infectious Disease SpecialistsNurse Practitioners

Physician AssistantsNursesResidents/Fellows and others desiring an update in these specialty areas

Target Audience

Program

SATURDAY, MARCH 26, 20117:30 a.m. Registration, Continental Breakfast & View Exhibits

8:30 a.m. Welcome & Introduction Paul Pockros, MD

NAfLD, NASh, PBC, PSC and AIh Moderator: Paul Pockros, MD 8:40 a.m. Advances in Non-Alcoholic fatty Liver Disease and Non-Alcoholic Steatohepatitis Steve Harrison, MD The William S. haubrich Lecture 9:30 a.m. What's New in Autoimmune hepatitis? Albert Czaja, MD

10:20 a.m. Break & View Exhibits

ControversyCorticosteroids or Pentoxyfyline for Acute Alcoholic hepatitis?

10:40 a.m. Corticosteroids Tarek Hassanein, MD

10:55 a.m. Pentoxyfyline Steve Harrison, MD

11: 10 a.m. Panel Discussion

11:40 a.m. Lunch

hepatitis B and C Moderator: Donald Hillebrand, MD 12:40 p.m. Triple Therapy for hCV in 2011 Douglas Dieterich, MD 1:30 p.m. update on hBV Paul Martin, MD 2:20 p.m. Changes in hCV Therapy for Difficult to Treat Patients and Beyond 2011 Paul Pockros, MD 2:50 p.m. Break & View Exhibits

Controversy Treating Decompensated hCV Cirrhotic with Antiviral Therapy: Yes or No? 3:20 p.m. Pro Douglas Dieterich, MD

3:35 p.m. Con Paul Martin, MD

4 p.m. Panel Discussion

4:30 p.m. Adjourn

SUNDAY, MARCH 27, 20117:30 a.m. Continental Breakfast & View Exhibits

ESLD, hCC and hepatic fibrosis Moderator: Jill Lane, MD

8 a.m. Diagnosis and Management of hepatocellular Carcinoma in 2011 Donald Hillebrand, MD

8:50 a.m. Management of End Stage Liver Disease and Alcoholic Liver Disease Norman Sussman, MD

9:40 a.m. Management of Non-Malignant Liver Tumors Randolph Schaffer, MD

10:30 a.m. Break & View Exhibits

Controversy Lactulose or Rifaximine as first Line Therapy for hepatic Encephalopathy?

11 a.m. Lactulose Norman Sussman, MD

11:15 a.m. Rifaximine Donald Hillebrand, MD

11:30 a.m. Panel Discussion Noon Adjourn

F I R S T, M I , L A S T N A M E D E G R E E ( M D , D O , P H D , R N , E T C . )

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Included: Course tuition, breakfasts, breaks, lunch and the course syllabus.Not Included: Travel costs, parking, lodging and dinners.

Conference Course Materials

Provided for all registered guests, but additional copies are available for purchase and will be mailed 2-4 weeks after the conference.

Printed Presentation Syllabus Only _____$75

full Conference Thru Feb 28 Mar 1 – Mar 22 Onsite after Mar 22 Physicians _____ $245 _____ $275 _____ $300

Nurses/Nurse PractitionersPhysician Assistants/PharmacistsAllied Health Professionals _____ $175 _____ $200 _____ $225

Fellows and Residents _____ $105 _____ $130 _____ $155

Please note: there are no day rates available for this conference.

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New Treatmentsin Chronic Liver Disease

March 26-27, 2011Hyatt Regency La Jolla at Aventine • San Diego, California

fouR EASY WAYS To REGISTER

online www.scripps.org/conferenceservicesfax 858-652-5565Phone 858-652-5400Mail Scripps Conference Services & CME Chronic Liver Disease 11025 North Torrey Pines Road Suite 200, Maildrop: SCRC200 La Jolla, California 92037 QuESTIoNS?Contact Scripps Conference Services & CMEPhone 858-652-5400Email med.edu@scrippshealth.org

ATTENDANCE PoLICIES

Registration ConfirmationA confirmation letter will be e-mailed or mailed to you upon receipt of the conference registration form and pay-ment. If you have not received it within two weeks, please contact the Scripps Conference Services & CME office.

Attendee Cancellation, Substitution, RefundThe course tuition is refundable, minus a $50 processing fee ($25 for Fellows and Residents), if your cancellation is received in writing no later than March 18, 2011. At-tendee substitutions are allowed, but notification must be made in writing by March 18, 2011. After this date, under no circumstances will refunds, credits, or substitu-tions be granted. No refunds or credits will be given to “no shows.”

Guest Attendance PolicyAll conference activities (including educational sessions, meal functions, exhibit hall, etc.) are exclusively reserved for conference attendees. Non-registered guests (includ-ing children, family members, colleagues, etc.) are not allowed in the conference areas. Badges provided at reg-istration are required for entrance into all functions and will be strictly enforced.

Scripps Conference Modification or CancellationScripps reserves the right to modify the course’s schedule or program as necessary. Scripps also reserves the right to cancel this conference, in which case a full refund of the registration fee will be provided. We are unable to refund any travel costs (flight, hotel, etc.) in the case of Scripps cancellation.

Recording and Photography ClauseScripps reserves exclusive rights to record (audio and video) and/or photograph all conference proceedings for use in marketing materials, presentations and course content sales.

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during this and many other Scripps educationalconferences, please contact:

Scripps Conference Services & CME858-652-5400

med.edu@scrippshealth.org

Conference Services & CME

11025 North Torrey Pines Road

Suite 200, Maildrop: SCRC200

La Jolla, California 92037

New Treatments in Chronic

Liver Disease

2 6 T h A N N u A L C o N f E R E N C E

March 26-27, 2011Hyatt Regency La Jolla at Aventine

San Diego, California

New Treatments in Chronic

Liver Disease

March 26-27, 2011Hyatt Regency La Jolla at Aventine

San Diego, California

2 0 1 1 C o N f E R E N C E h I G h L I G h T S• Comprehensive presentations of the latest advances in hepatology with renowned faculty chosen for their expertise as well as teaching skills.

• Controversies presented on the treatment of Decompensated HCV, Acute Alcoholic Hepatitis and Hepatic Encephalopathy.

• Audience Response System incorporated for instant feedback and interactive learning.

• Endorsed by the American College of Gastroenterology

• Attendees will have opportunities to network with each other and interact with speakers to discuss topics from the course.

Th

NEWC O N F E R E N C EL O C A T I O N !

HepatologistsGastroenterologists

Infectious Disease SpecialistsNurse Practitioners

Physician AssistantsNursesResidents/Fellows and others desiringan update in these specialty areas

Target Audience

26A N N u A L

Endorsed By