a301 vi-various cancer tissues with - biocat gmbhvi).pdf · 2013. 4. 18. · nocoordinate sex age...

For research use only(formalin fixed)

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A301 VI- Various cancer tissues with

corresponding normal tissues

Specifications:

• No. of cases: 28

• Tissue type: Various cancer tissues with


• No. of spots: 2 spots from each cancer case (56 spots)

28 non-neoplastic spots (28 spots)

•Total spots: 84

• Corresponding normal tissues with cancers: Yes

• Diameter: 1. 0 mm

Documents:

• Product specification: layout, summary of tissue spots

• H&E stained images

• Detailed pathological information

Layout:

Summary of tissue spotsFor research use only(formalin fixed)

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QC sheet_LOT#132121010141

Hematoxylin and Eosin staining


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A1 A2 A3 A4

A5 A6 A7 A8

A9 A10 A11 A12

B1 B2 B3 B4

B5 B6 B7 B8

B9 B10 B11 B12


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C1 C2 C3 C4

C5 C6 C7 C8

C9 C10 C11 C12

D1 D2 D3 D4

D5 D6 D7 D8

D9 D10 D11 D12


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E1 E2 E3 E4

E5 E6 E7 E8

E9 E10 E11 E12

F1 F2 F3 F4

F5 F6 F7 F8

F9 F10 F11 F12


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G1 G2 G3 G4

G5 G6 G7 G8

G9 G10 G11 G12

No Sex Age Key word Histological Diagnosis

1 A 1,2 f 52

adrenal gland:

pheochromocytoma

1. Adrenal gland, right, adrenalectomy: pheochromocytoma

1) high nuclear grade

2) clear cells: less than 25%

3) presence of capsular invasion,

4) consistent with adrenal cortical carcinoma, by modified Weiss histopathologic criteria.

5) immunohistochemical stain: chromogranin A, NSE, Synaptophysin: (+)

2 A 3 f 52 non-neoplastic non-neoplastic from A1,2

3 A 4,5 m 62

esophagus:

squamous cell

carcinoma

Esophagus and cardia of stomach, esophagectomy and node dissection:

1.Ulcerative squamous cell carcinoma, poorly differentiated,

1) size: 3.3x1cm

2) extension to the outer muscle layer

3) lymphovascular permeation: Positive

2.Resection margins, proximal and distal: Free of tumor.

3.Regional lymph nodes: Free of tumor in all nodes(0/24), in detail, subcarinal(0/10), hilar(0/2),

pretracheal(0/6),lower paratracheal(0/3), left paracardial(0/2), 8L(0/1),omental mass(Free of tumor).

4 A 6 m 62 non-neoplastic non-neoplastic from A4,5

5 A 7,8 m 35

salivary gland:

pleomorphic

adenoma

Salivary gland, parotid, right, parotidectomy: Pleomorphic adenoma.

6 A 9 m 35 non-neoplastic non-neoplastic from A7,8

7 A10,1

1m 20

terminal ileum:

diffuse large cell

lymphoma

Terminal ileum, segmental resection: diffuse large B cell lymphoma

1) resection margin: lymphoid hyperplasia

2) lymph node: reactive hyperplasia

3) appendix: no pathological diagnosis

4) immunohistochemical staining results: CD20, CD10: diffuse (+), Bcl-6: focal (+), CD3: (-)

Ki-67 proliferation index: about 70%.

8 A 12 f 60 non-neoplastic non-neoplastic from A10,11

Coordinate

A301 VI: Various cancer tissues with corresponding normal tissues

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No Sex Age Key word Histological DiagnosisCoordinate


9 B 1,2 m 59liver: hepatocellular

carcinoma

Liver, right lobe, lobectomy: hepatocellular carcinoma

1) size: 8x8x6.8cm

2) edmondson-steiner grade III

3) clear cell(majority) and trabecular histologic type

4) single nodular type with perinodal spreading growth

5) necrosis: less than 10% of total volume

6) microvascular invasion

7) intact intrahepatic resection margin

8) nonneoplastic liver showing: chronic hepatitis, B viral, with mild inflammatory activity(grade II) and

early bcirrhosis (stage III).

10 B 3 m 59 non-neoplastic non-neoplastic from B1,2

11 B 4,5 m 51thyroid gland:

papillary carcinoma

Thyroid gland, total thyroidectomy with neck node dissection:

1.Papillary carcinoma

1) involving bilateral whole lobe(size: 6.5x3.7cm)

2) extension to perithyroidal fat tissue

2.Regional lymph node: tumor metastasis to 4 out of 20(4/20), in detail, level II(1/2), level III(3/13), level IV(0/5).


13 B 7,8 m 70soft tissue: diffuse

large cell lymphoma

Soft tissue and lymph node, neck, left, radical neck dissection:

1) soft tissue: diffuse large B cell lymphoma

2) lymph nodes, separately submitted as level ia(0/7), level iB(0/11), level iV(0/16) and

level V(0/17): (0/51): reactive hyperplasia

3) salivary gland in level IB: free of tumor

4) tonsil, left, tonsillectomy: chronic follicular tonsillitis

5) immunohistochemical staining results CD20: positive to tumor cells CD3, CD4, CD8, Granzyme, CD30,

CD56, ALK: negative to tumor cells

6) EBER ISH (-).


15 B10,1

1m 36

skin: invasive

squamous cell

carcinoma

Skin, scalp, excision: Invasive squamous cell carcinoma,

1) well-differentiated with extension to the subcutaneous fat tissue (invasion depth: about 3cm)

2) resection margins, all circumference and base: free of tumor

3) lymph nodes, level 2a(0/36), level 2b(0/11), level III(0/25), level IV(0/13) and

level V(0/11):(0/96): free of tumor.


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17 C 1,2 m 52

urinary bladder:

Papillary urothelial

carcinoma

Urinary bladder including prostate, seminal vesicle and ureter, radical cystectomy:

1. Urinary bladder: Papillary urothelial carcinoma, high grade,with squamous differentiation, with various pathologic

state including low grade papillary urothelial carcinoma, urothelial tumor of low malignant potential, carcinoma

in situ and papilloma, with extension to the perivesical soft tissue and prostate, and with extensive lymphatic,

venous and perineural invasion, incompletely excised.

2. Seminal vesicle: Free of tumor.

3. Ureters, bilateral, resection margins: Free of tumor.

18 C 3 m 52 non-neoplastic non-neoplastic from C1,2

19 C 4,5 m 79tonsil: squamous

cell carcinoma

Tonsil, left, wide excision with right neck dissection:

squamous cell carcinoma, poorly differentiated

1) size: 3.6x1.5x1.2cm

2) lymphatic permeation: uncertain

3) resection margin, base: free of tumor, margin is very close (less than 1mm)

4) resection margin, lateral: free of tumor

5) lymph node, right, level Ia(0/2), II(0/11), III(0/5), IV(0/4): (0/22): free of tumor

6) lymph node, left, level Ib(0/7), IIa(3/3), IIb(1/2), III(5/7), IV(1/1), V(0/16):(10/36): tumor metastasis, see note.

7) separately submitted lymph node, Ib(0/1), IIb(0/1): free of tumor

Note: The largest lymph node involved by tumor measures 1.8x1.3cm in level III of the left side.


21 C 7,8 f 70lung: squamous cell

carcinoma

Lung, right lower lobe, lobectomy:

squamous cell carcinoma, moderately differentiated

1) size: 7x5cm

2) extension to the visceral pleura

3) associated obstructive pneumonitis

4) bronchial resection margin: free of tumor.

22 C 9 f 70 non-neoplastic non-neoplastic from C7,8

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23 C10,1

1m 55

lung:

adenocarcinoma

Lung, left lower lobe, lobectomy:

adenocarcinoma, acinic and papillary with

1) marked mucin production

2) size: 4.7x4.6cm

3) extension to visceral pleura

4) bronchial resection margin: free of tumor

5) regional lymph node, peribronchial: tumor metastasis(1/1).


25 D 1,2 m 52Pancreas:

Adenocarcinoma

Pancreas, distal pancreatectomy:

1.Adenocarcinoma, moderately differentiated

1) Size: 3.5x2.5cm

2) Tumor involvement: Extension to peripancreatic soft tissue and encircling the common hepatic artery

without invasion.

3) Vascular invasion: Present

4) Neural and perineural invasion: Frequently present

2.Resection margin, pancreas: Free from tumor

3.Resection margin, circumferential: Free from tumor (margin of clearance: 20um)

[Non-neoplastic pancreas]

Chronic pancreatitis with parenchymal atrophy at tail portion of pancreas.

Lymph nodes, peripancreatic : (4/13) Metastatic carcinoma in 4 out of 13 lymph nodes.

26 D 3 m 52 non-neoplastic non-neoplastic from D1,2

27 D 4,5 m 62Prostate:

adenocarcinoma

Prostate, radical prostatectomy:

1.Adenocarcinoma, Gleason score 7(4+3) involving both sides of lobes,

multifocally, confined to prostatic parenchyme without capsular involvement.

2.Seminal vesicles, bilateral: Free of tumor.

3.Lymph node, iliac, dissection: Free of tumor in all 14 lymph nodes (0/14), in detail, right(0/7) and left (0/7).


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29 D 7,8 m 66colon:

adenocarcinoma

Colon, rectum, lower anterior resection:

adenocarcinoma, well differentiated, polypoid

1) size: 4.2x2.5cm

2) confined to the mucosa

3) associated low and high grade tubulo-villous adenoma

4) resection margins, proximal and distal: free of tumor

5) regional lymph nodes: free of tumor in all nodes(0/21), regional(0/21), principal(0/0).


31 D10,1

1m 45

colon:

adenocarcinoma

Colon, rectum, lower anterior resection:

1.colon: ulcerofungating adenocarcinoma, moderately differentiated,

1) size: 5.5x4.5cm

2) extension to the pericolic fat tissue(pT3c)

3) lateral margin: free of tumor

4) lymphovascular permeation(+)

2.urinary bladder: free of tumor

3.resection margins, proximal and distal: free of tumor

4.regional lymph nodes: tumor metastasis to 4 out of 11(4/11), in detail, regional(4/8), principal(0/3).


33 E 1,2 f 70stomach:

adenocarcinoma

Stomach, pancreas and spleen, radical total gastrectomy, splenectomy and pancreatectomy:

1.Stomach: ulceroinfiltrative adenocarcinoma, moderately differentiated,

1) size: 10.7x9cm

2) extension to the serosa and pancreas parenchyme

3) lymphovascular permeation: positive

4) Intestinal type by Lauren's classification

2.Resection margins, proximal and distal: free of tumor

3.Resection margin, pancreas: free of tumor

4.Regional lymph nodes: tumor metastasis to 2 out of 47(2/47), in detail, N1(0/5), N3(0/5), N4(0/8), N5(0/2),

N6(1/16), N7(0/2), N8(1/4), N9(0/2), N10(0/3)

5.Pancreas: tumor extension

6.Spleen: congestion.

34 E 3 f 70 non-neoplastic non-neoplastic from E1,2

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35 E 4,5 m 67stomach: signet ring

cell carcinoma

Stomach, subtotal gastrectomy:

1.ulceroinfiltrative signet ring cell carcinoma

1) size: 4.5x4cm

2) extension to the serosa(serosa attached)

3) lymphovascular permeation: positive

4) perineural invasion: positive

5) diffuse type by lauren's classification

2. resection margins, proximal and distal: free of tumor

3. regional lymph nodes: tumor metastasis to 3 out of 31(3/31), in detail, N3(0/6), N4(0/7), N5(1/2),

N6(2/5), N7(0/10), N12(0/1).

36 E 6 m 67 non-neoplastic non-neoplastic from E4,5

37 E 7,8 f 65kidney: renal cell

carcinoma

Kidney, left, radical nephrectomy:

1.Renal cell carcinoma, conventional(clear cell) type

1) Fuhrman's nuclear grade: IV

2) Foci of sarcomatoid differentiation

3) Invasion to the perinephric fat tissue but not to Gerota's fascia

4) Renal vein involvement(pT3b)

2.Resection margin, ureter: Free of tumor.

3.Resection margin, renal vein: Presence of tumor.

4.Lymph nodes, perihilar(0/11), paraaortic(0/2) and left common iliac(0/3): Free of tumor metastasis in all 16 nodes.

5.Adrenal gland: Free of tumor.

38 E 9 f 65 non-neoplastic non-neoplastic from E7,8

39 E10,1

1m 52

kidney: renal cell

carcinoma

1. Kidney, left, nephrectomy: renal cell carcinoma, clear cell type

1) size: 4x4cm

2) confined within the renal capsule

3) nuclear grade II

4) renal artery and vein: free of tumor

2. Ureter resection margin: free of tumor

3. Adrenal gland: free of tumor.

40 E 12 m 52 non-neoplastic non-neoplastic from E10,11

41 F 1,2 f 21

parotid gland:

pleomorphid

adenoma

Parotid gland, right, parotidectomy:

1.Pleomorphic adenoma.

2.Lymph node: Reactive hyperplasia.

42 F 3 f 21 non-neoplastic non-neoplastic from F1,2P-07-04-13T



43 F 4,5 f 15ovary: yolk sac

tumor

Ovary and fallopian tube, right, right salpingooophorectomy:

1) ovary: malignant germ cell tumor, probably yolk sac tumor (endodermal sinus tumor)

2) fallopian tube: paraovarian cyst

3) result of special stain: AFP(+), HCG(-), PAS(+), D-PAS(-).

44 F 6 f 15 non-neoplastic non-neoplastic from F4,5

45 F 7,8 f 47uterus:

adenocarcinoma

Uterus with right adnexa, total abdominal hysterectomy with right salpingooophorectomy:

1.Cervix: Invasive squamous cell carcinoma, moderately differentiated,

mixed with adenocarcinoma, moderately differentiated

1) size: 4x3cm

2) extension to lower 1/3 of the wall (invasion depth: 1.9cm)

3) lymphatic permeation: positive

4) lateral margin: Free of tumor.

2.Endometrium: Secretory phase.

3.Myometrium : 1. Leiomyomas, intramural.


47 F10,1

1f 40

uterus: squamous

cell carcinoma

Uterus with lymph nodes, pelvic, radical abdominal hysterectomy with dissection:

1.Cervix: Invasive squamous cell carcinoma, large cell, keratinizing

(invasion depth: 1.1cm) with focal lymphovascular permeation.

2.Endometrium: Proliferative phase.

3.Myometrium : Adenomyosis.

4.Parametria, bilateral: Free of tumor.

5.Vaginal cuff: Free of tumor.

6.Lymph nodes, right pelvic(0/4), left pelvic(0/6), regional(0/2):(0/12): Free of tumor.


49 G 1,2 f 52breast: Invasive

lobular carcinoma.Breast, left, lumpectomy: Invasive lobular carcinoma.

50 G 3 f 52 non-neoplastic non-neoplastic from G1,2

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51 G 4,5 m 52cecum:

adenocarcinoma

Cecum, ascending colon, terminal ileum and appendix, right hemicolectomy:

1.Ulcerofungating adenocarcinoma, moderately differentiated, inascending colon

1) size: 5x4cm

2) expanding growth

3) invasion to pericolic soft tissue.

4) vascular invasion.

5) intact proximal (terminal ileum) and distal (colon) resection margins.

6) metastasis to 2 out of 32 pericolic lymph nodes.

7) a tubular adenoma with low grade dysplasia in the surrounding mucosa.

8) Terminal ileum: Prominent peyer's patch.

9) Appendix: Free from tumor extension.

52 G 6 m 52 non-neoplastic non-neoplastic from G4,5

53 G 7,8 m 36 Testis:Seminoma

Testis, left, orchiectomy:

1.Seminoma with invasion beyond tunica albuginea(pT2) and associated with intratubular germ cell neoplasia.

2.Spermatic cord: Free of tumor


55 G10,1

1m 31

Thymus:

thymoma

Thymus, thymectomy:

1.Type B2 thymoma (cortical thymoma by Muller-Hermelink scheme)

1) size: 8x5.5cm

2) confined to the thymic capsule(pT1) (Masaoka's stage I).

3) multilocular thymic cyst

4) resection margin: Free of tumor.

2. Adenomyosis.

3.Ovary: No pathological diagnosis.

4.Fallopian tube: Paratubal cyst.

5.Parametrium, bilateral: Free of tumor.

6.Vaginal cuff: Free of tumor.

7.Regional lymph nodes: Free of tumor in all nodes(0/4), in detail, paraaortic(0/0), left pelvic(0/2), right pelvic(0/2).


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