RTA3G

NC

NCNucleic Acid

A3G

Roadblock Mechanism for Deaminase-Independent Inhibition of HIV-1 Reverse

Transcription by A3G

Iwatani et al. Nucleic Acids Res. 35:7096 (2007)

- Unlike A3G, RT has poor binding affinity to single-stranded nucleic acids. Thus, RT cannot readily displace A3G once it is bound to the single-stranded RNA or DNA template and RT-catalyzed DNA elongation is blocked. - NC binding to nucleic acids exhibits a high on-off rate and NC function is not affected by A3G.

A3G, APOBEC3G RT, reverse transcriptase NC, nucleocapsid protein