aan –toronto, april 11, 2010
DESCRIPTION
AAN –Toronto, April 11, 2010. Development of a harmonized protocol for hippocampal tracing An EADC-ADNI joint effort INTRODUCTION. BACKGROUND Hippocampal volume as a diagnostic marker. Structure: MR hippo volumetry. Function: FDG PET. Amyloid deposits: PET. Biochemistry: CSF - PowerPoint PPT PresentationTRANSCRIPT
AAN –Toronto, April 11, 2010
Development of a harmonized protocol for hippocampal tracing
An EADC-ADNI joint effort
INTRODUCTION
Structure:MR hippo volumetry
Alz
he
ime
r
Normal
CS
F t
ota
l ta
u
CSF Abeta42
Biochemistry:CSF tau/Abeta
Function:FDG PET
Amyloid deposits:PET
BACKGROUNDHippocampal volume as a diagnostic marker
Dubois, Feldman et al., Lancet Neurol 2007
Geuze et al., Mol Psychiatry 2005;10:147-59
Ref. Med borderLat border
Inf border
Norm. hippo vol (cm3)
Left Right
Watson et al.
Mesial edge of temporal lobe
Temp horn of lat ventr
Incl subicular complex & uncal cleft w/ border separating subicular complex from parahippo gyrus
4.903 5.264
Zipursky et al.
Regional outline at choroidal fissure
Not mentioned
The interface of hippocampal tissue and parahippocampal gyrus white matter
1.990 2.070
BACKGROUNDThe effect of segmentation protocols
on hippocampal volume
BACKGROUNDHippocampal volume as an outcome measure
in trials of disease modifiersDrug Study Effect Segment. method Ref
Tramiprosate Alphase 68% (100 mg)120% (150 mg)
n.m. Gauthier et al., JNHA 2009
Atorvastatin ADCLT “Chv* mm³ -134±174 vs -583±354 p> .05”
Manual protocolInsausti et al., 1998 AJNR;
Machulda et al., 2001, Neuroimage
Sparks et .a,l CCJM,2008
LEADe “significant at p<.05”
MIDAS(semiautomated)
Jones et al., Alz&Dem 2008Feldman et al., Neurology 2010
AN1792 “Chv* % 3.78±2.63 vs 2.86±3.19
p = 0.124”
Manual protocolWatson et al., 1992, Neurology
Fox N et al., Neurology, 2005
Xaliproden Sanofi-Aventis Trials
“significant atrophy” § n.m. From Vellas B et al. (Review), Lancet Neurol.,2008
Donepezil “p= 0.07”ε4 carriers only
Manual protocolJack et al., 1989;Radiology
Jack et al., 2004; Neurology
Jack CR et al., Neurobiol. Aging, 2008
* Chv= Change in hippocampal volume; § referenced link not working; n.m. = not mentioned
BACKGROUNDHippocampal volume (manual segmentation)
as gold standard for automated segmentation algorithms
Morey et al., NeuroImage 2009
To Harmonize Available Protocols for Manual Hippocampal Segmentation
To Test the Validity of the Harmonized Protocol
AIMS
F Barkhof/P Scheltens Amsterdam B Dubois/S Leherici ParisN Fox LondonGB Frisoni BresciaH Hampel/J Pantel FrankfurtA Simmons LondonH Soininen KuopioS Teipel RostockLO Wahlund Stockholm
THE WORKGROUPEADC
CR Jack Jr Rochester, MNG Barzokis UCLA, CAD Bennet Chicago, ILJ Csernansky NorthW U, WAC DeCarli UC Davis, CAM De Leon New York, NYJ Kaye Portland, ORR Killiany Boston USM, MAPM Thompson LoNI, UCLA, CAM Weiner/S Mueller UCSF/VAMC
THE WORKGROUP ADNI
THE WORKGROUPother relevant hippo experts
R Camicioli Univ Alberta, CanadaJ O’Brien NewCastle, UKJ Pruessner McGill, QC, Canada
EADC-ADNI P.I.sB Vellas Toulouse, FranceB Winblad Stockholm, SwedenM Weiner UCSF, US
Population-based studiesM Breteler / T Den Heijer Rotterdam Scan StudyP Sachdev/ JJ Maller PATH through lifeL Launer NIA BethesdaW Jagust Berkeley
THE WORKGROUPAdvisory Boards
Statistical BoardS Duchesne Laval Univ, CanadaL Collins MNI, McGill, MontrealP Pasqualetti AFaR, Rome
Clinical AdvisorPJ Visser Maastricht, The Netherlands
Dissemination/EducationG Waldemar Copenhagen, Denmark
THE WORKGROUPBoards
Marina Boccardi psychologist, PhDRossana Ganzola psychologistEnrica Cavedo psychologistMichela Pievani mathematicianAnna Caroli mathematicianAlberto Redolfi bioinformaticist
THE WORKGROUPPersonnel in Brescia