ABP Testing EssentialsWADA ABP Symposium 2018

Matthew Fedoruk, PhD

www.usada.org

Educate - Where do I find information?

Guidelines

• ABP Guidelines 6.1

• Implementing an Effective Testing Program 1.0

Standards & Technical Documents

• International Standard for Testing & Investigations (ISTI) 2017

• ISTI Annex K - Collection, Storage and Transport of Blood ABP Samples

• Annex L – Results Management Requirements and Procedures for the Athlete Biological Passport

• Technical Document for Sport Specific Analysis (TDSSA) 3.1

• TDSSA FAQs – Supporting Document B

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Testing Guides APMUs, Labs & ADOs

• Erythropoietic Stimulating Agents (ESAs)

• Growth Hormone (GH) & Growth Hormone Releasing Factors (GHRFs)

• Scientific, Technical & Practical Experience

• APMU reports

• Previous cases

• Peer-reviewed literature

Why the ABP?

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The Passport can lead to an Anti-Doping Rule Violation by:

• Adverse Analytical Finding (AAF), Code Article 2.1: Improved target testing and flagging samples for analytical drug tests (e.g. EPO), leading to direct detection of prohibited substances

• Adverse Passport Finding (APF), Code Article 2.2: Identifying profiles requiring expert review. Experts must assess atypical profiles and determine if they are the result of normal physiological variation, a pathology, or a doping scenario

ToxicologicalForensic

Who to Test?

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Sottas, 2018, Moving from Testing to Strategic Testing: The Athlete Biological Passport

Plan - Who to Test?

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New Athlete

No Data

Established Athlete

Normal ABP

New or Established Athlete

Atypical ABP

ABP Program Inclusion - Risk Assessment

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ABP Program Inclusion

Focus on Maximizing Detection & Deterrence

Intel

Performance

TDSSA

Testing - How many tests in enough?

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Guiding Principles

• Gather meaningful data – right athlete, right test, right time– Dynamic risk assessment

– Test planning & ADO collaboration

• Use data gathered through the ABP effectively – interpretation & follow-up action– APMU & Expert reports

– Communication with intel & legal teams

– Communication between ADOs

– Action!

When and Where to Test? Athlete-Focused ABP

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Example ABP Distribution – Annual Testing Strategy

Preparation

Competition

Recovery

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• 3 tests per athlete per year; adjust based on APMU reports

Interpret - How many tests is enough? Testing Scenarios

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Sottas, 2018, Moving from Testing to Strategic Testing: The Athlete Biological Passport

Holistic Approach Gathering Data - Sources of Information

In-house Information

• Biological (ABP) data & APMU guidance

• Testing histories & Frequency

• Doping Control Form data

• Doping Control Officer After Action Reports

• Whereabouts information & Updates

• Play Clean Tips

• Sanctioned athletes

• Competition results & rankings

• WADA investigations

• WADA-accredited Laboratories

• Prior cases

Information to Seek-Out

• Government investigations

• Government databases

• Relationships with law enforcement

• Civil cases

• Media reports

• Reporters

• Blogs/Websites

• Twitter and other social media

• Fellow competitors

• Coaches

• Event organizers

• Other trusted sources

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Leverging Existing Data

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New Analytics-based Testing Strategies

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Theory to Practice = Effective ABP

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Plan

Test

Interpret

React

Educate

Thank you! mfedoruk@usada.org

www.usada.org