abstracts - annals of the rheumatic diseases · ann. rheum. dis. (1971), 30, 545 abstracts...

Ann. rheum. Dis. (1971), 30, 545

Abstracts

These abstracts have been specially commissioned for this Journal. Many of the titles have been taken fromAbstracts of World Medicine and Ophthalmic Literature, published by the British Medical Association, andthe references to these sources are given. The subjects are arranged in the following sub-sections:

Rheumatic FeverRheumatoid ArthritisStill's DiseaseOsteoarthrosisSpondylitisGout

Other Forms of ArthritisBone DiseaseNon-articular Rheumatism, including DiscSyndromes, Sciatica, etc.

Connective Tissue StudiesPararheumatic (Collagen) Disease

Immunology and SerologyBiochemical StudiesTherapySurgeryOther General Subjects

Not all sub-sections may be represented in any one issue.

Rheumatic feverRheumatic Heart Disease, 1970. A Brief Review for theGeneral Practitioner PEAK, H. J. (1971) Med. J. Aust.,1, 1122

Role of the Pediatrician In Rheumatic Fever ControlMORTIMER (1971) Pediatrics, 47, 1

Prophylahis of Inflammatory Heart Disease with SpecialReference to Rheumatic Fever [In German] ANscHUTZ,F. (1971) Med. Welt (Stuttgart) 22, 543

A Newly Prevalent Type of Beta-Hemolytic Streptococcusin Chicago POrrER, E. V., Sm.GAL, A. C., and BEARFELD,J. L. (1971) Amer. J. Epidem., 93, 102 2 figs, 21 refs

Rheumatoid arthritis'Contact Lens' Cornea In Rheumtoid Arthritis LYNE,A. J. (1970) Brit. J. Ophthal., 54, 410 4 figs, 5 refs

A peripheral corneal opacity of a distinctive character,involving the anterior third of the comeal thickness, was

seen in five patients with long-standing rheumatoidarthritis. The opacity was present over the whole of thecircumference of the peripheral cornea in most of the eyesaffected and the condition was bilateral to some degree inall five patients.

Inflammation and vascularization were minimal.AUTHOR'S SUMMARY

Peripheral Corneal Opacification and Skeletal Deformities.A Newly Recognised Acid Mucopolysaccharidosis simula-ting Rheumatoid Arthritis BROWN, S. I., and KUwABARA,T. (1970) Arch. Ophthal. (Chicago), 83, 667 13 figs,16 refs

Two female sibs are presented, with peripheral cornealopacities and severe progressive intra-articular jointdestruction. Fibroblast cultures of skin biopsies showedan increase in intracellular mucopolysaccharides andthese two patients are considered to be suffering from a

new autosomal recessive mucopolysaccharidosis.BARRE JAY

Involvement of the Lateral Atlanto-axial Joints as Firstand Late Symptom of Rheumatoid Arthritis [In English]VAN KERCKHOVE, H. (1970) Acta rheum. scand., 16, 19710 figs, 2 refs(Abstr. Wld Med. (1971), 45, 524)

Preoperative Evaluation of Patients with RheumatoidArthritis MATHEWS, R. S., BUCKLEY, C. E., HI, DORSEY,F. C., LINCOLN, C. R., and MCCOLLUM, D. E. (1971)Sth. med. J. (Bgham, Ala.), 64, 138 4 figs, 9 refs

Femoral Neck Fracture of the Rheumatoid Hip JointVAHVANEN, V. (1971) Acta rheum. scand., 17, 125 4 figs,14 refs

Rheumatoid Arthritis with Diffuse Arteritis [In French]LIAVRE, J. A., CHoMETrE, G., CAMUs, J. P., BtWICHOU, C.,GUILLIEN, P., and CROUZET, J. (1971) Sem. Hop. Paris,47, 1612 (English summary, p. 1617) 3 figs, 35 refs

Rheumatoid Arthritis and Rheumatoid Heart DiseaseBARKER, A. (1971) N.Z. med. J., 73, 14 5 figs, 39 refs

Renal Disorders In Rheumatoid Arthritis BURRY, H. C.(1971) Rheum. phys. Med., 11, 2 5 figs, 51 refs

Oedema in Rheumatoid Arthritis: Changes in the Co-efficient of Capillary Filtration JAYSON, M. I. V., andBARKs, J. S. (1971) Brit. med. J., 2, 555

Rheumatoid Synovial Cyst of the Hip SAMUELSON, C.,WARD, J. R., and ALBO, D. (1971) Arthr. and Rheum.,14, 105 17 refs

Psychological Aspects of Rheumatoid Arthritis Mos-KOWITZ, R. W. (1971) J. Albert Einstein med. Centre, 19,36 5 refs

Psychological Study of Rheumatoid Arthritis and SelectedControls ROBINSON, H., KuRK, R. F., JR., and FRYE,R. L. (1971) J. chron. Dis., 23, 791 1 fig., 20 refs

Psychosomatic Aspects of Rheumatoid Arthritis DU BOis,R. (1971) Praxis, 60, 747

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546 Annals of the Rheumatic Diseases

Rutod Arthrtis and Psonality: A Controlled StudyWARD, D. J. (1971) Brit. med. J., 2, 297, 18 refs

ChInges of the Metatarsl Head in Patients with Rheu-matoid Arthriti A Hbtological, Tetracycine-fluorescencead Microradogaphical Study [Monograph.] [In English]ROKKANEN, P., JULKUNN, H., and LAmW, H. (1971)Acta rheum. scand., Suppl. 16 21 figs, 32 refs

Rapid Method for evaluating the Strcture and Function ofthe Retoid Hand TREuHA, P. S., LEws, M. R.,and MCCARTY, D. J. (1971) Arthr. and Rheum., 14, 754 figs, 15 refs

Tenography of the RIeumatoid Hand BREWERTON, D. A.(1971) Rheum. phys. Med., 11, 34 1 fig., 2 refs

Zig-Zag Deformity in the Rheumatoid Hand STACK andVAUGHAN-JACKSON, 0. (1971) Hand, 3, 62

Relationship of Wrist Motion to Ulnar ianugad Driftin the Rheumtoid Patient SHAPIRO et al. (1971) Hand,3, 68

Trigger Finger Syndrome In Rheumatoid Arthritis notcaused by Flexor Tendon Nodules STELLBRINK (1971)Hand, 3, 76

Canine Rleumatoid Arthitis LEWIS, R. M., and BOREL,Y. (1971) Arthr. and Rheum., 14, 67 6 figs, 10 refs

OsteoarthrosisBouchard's Nodes (La nodosite de Bouchard) SEZE, S. DE,DREYFUS, P., MENZA, C. DI, DEBEYRE, N., and SToRA, P.(1970) Rev. Rhum. 37, 693 2 figs, 18 refs(Abstr. Wld Med. (1971), 45, 437)

Weight-bearing Radiogrphy in Osteoarthritis of the KneeLEACH, R. E., GREGG, T., and SIBER, F. J. (1970) Radi-ology, 97, 265 6 figs, 4 refs(Abstr. Wld Med. (1971), 45, 472)

Walking Patterms of Patients with Unilateral Hip Pain dueto Osteoarthrltis and Avascular Necrosis MURRAY,M. P., GORE, D. R., and CLARKSON, B. H. (1971) J. BoneJt Surg., 53-A, 259 5 figs, 14 refs

Clinical Pattern of Reumatoid Artaritis in Patients withRhematoid Nodules MALDYK, H., and SLOTWINuSKA, L.(1971) Pol. med. J., 10, 1, 24 2 figs, 15 refs

Studies in Osteoartwitis of the Hip: I. ClaificationGOFTON, J. P. (1971) Canad. med. Ass. J., 104, 6795 figs, 13 refsH. Osteoarthritis of the Hip and Leg-Length DisarityGOFrON, J. P., and TRUEMAN, G. E. (1971) Canad. med.Ass. J., 104, 791 6 figs, 14 refsIII. Congenital Subluxation and Osteoarthritis of the HipGorTON, J. P. (1971) Canad. med. Ass. J., 104, 9114 figs, 8 refs

SpondylitisImmunuorescence Studies on Kidney Biopsies inAnkYlOsng SPondyiis LminaR, E., and PASTERNACK, A.(1970) Acta path. microbiol. scand., 78B, 517 6 figs,18 refs

Rarity of Ankylosing Spondylitis In the Black RaceBAUM, J., and ZIFF, M. (1971) Arthr. and Rheum., 14, 1227 refs

Fibrosing Interstitial Pneumonitis in Ankylosing Spondy-lits COHEN, A. A., NATELSON, E. A., and FECHNER,R. E. (1971) Chest, 59, 369 3 figs, 13 refs

Chloroma following Irmdiation in Ankylosing SpendylitisGARDNE-THORPE, C., and NEOPHYTOU, M. (1971) Med.J. Aust., 1, 1121 12 refs

Radiotherapy of AnKylosng poodylltis and RadiationLeukaemla (Spondylarthrites ankylosantes irradi&es etradioleuc6mie) GUIRAUD, G. (1971) J. Radiol. tlectrol.,52, 163 26 refs

GoutDiminished Renal Urate Secretion per nephron as a Basisfor Prmary Gout RIEsELBACH, R. E., SORENSEN, L. B.,SHELP, W. D., and STEELE, T. H. (1970) Ann. intern. Med.,73, 359 4 figs, 16 refs

This is a study of renal transport mechanisms in primarygout. From uric acid turnover data using "4C-labelleduric acid, and by comparison with control subjects,fifteen patients with gout were separated into two groupsof nine uric acid overproducers and six normal producers.These two groups were compared with regard to urateexcretion, the factors of tubular reabsorption and secre-tion being analysable separately by the administration ofpyrazinamide, which suppresses the latter. Studies wererepeated after allopurinol-induced normouricaemia, sothat values were obtained over a wide range of plasmaurate and filtered urate load levels.Both groups were found to have a normal pattern of

urate reabsorption, this being virtually complete in allcases. Tubular secretion, however, differed, in thatoverproducers secreted urate at the normal rate whilenormoproducers showed a diminished rate of secretion.An abnormality of renal tubular behaviour is thus shownto be a significant factor in at least a substantial propor-tion of gout patients. J. T. SCOrr

Uric Oxidase in the Treatment of Gout and Hyperuri-caemia (L'urate-oxydase dans le traitement de la goutte etde l'hyperuric6mie) LouYOT, P., MONTET, Y., RoLAND,J., and POUREL, J. (1970) Rev. Rhum., 37, 795 12 refs(Abstr. Wid Med. (1971), 45, 437)

Symposium on Hyperurickmie et Pathologie, 1971 Ann.Hyg. Lang. franp.-Med. et Nut., 7, 11-107 (8 articles)

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Abstracts 547

Rheumatoid Arthritis and Gout in Hiroshima and Nagasaki,Japan KATO, H., DUFF, I. F., RussEL, W. J., UDA, Y.,HAMILTON, H. B., KAWAMOTO, S., and JOHNSON, K. G.(1971) J. chron. Dis., 23, 659 4 figs, 18 refs

Gout. Some Clinical Observations CORMACK (1971)J. roy. Army med. Cps, 117, 24

Clinical Experience in the Long-term Treatment of Goutwith lodinated and Brominated Benzofurane Derivatives[In French] MASBERNARD, A., GUILBAUD, J., andDRONIOU, J. (1971) Lyon mid., 225, 683 6 figs, 38 refs

Uricosuric Action of Cholecystographic Agents: PossibleNephrotoxicity MUDGE (1971) New Engl. J. Med., 284,929

Renal Urate Transport in The Chimpanzee FANELLIet al. (1971) Amer. J. Physiol., 220, 613

Hereditary Susceptibility to Dietary Induction of Gout inSelected Lines of Chickens PETERSON et al. (1971) J.Nutr., 101, 347

An Unusual Form of Renal Disease associated with Goutand Hypertension GOOR, W. VAN, KOOIKER, C. J., andMEES, E. J. D. (1971)J. clin. Path., 24, 354 3 figs, 22 refs

Lesch-Nyhan Syndrome: Altered Kinetic Properties ofMutant Enzyme MCDONALD and KELLEY (1971)Science, 171, 689

A Method for Deriving Normal Ranges from LaboratorySpecimens applied to Uric Acid in Males COOK et al.(1970)J. clin. Path., 23, 778

Serum Urate Levels and Gout in Australian MalesJEREMY, R., and TOWSON, J. (1971) Med. J. Aust., 1, 11161 fig., 10 refs

Serum Uric Acid and Cholesterol in Achievement Behaviorand Motivation: I. The Relationship to Ability, Grades,Test Performance, and Motivation KASL, S. V., BROOKS,G. W., and RODGERS, W. L. (1970) J. Amer. med. Ass.,213, 1158

Hyperuricemia in American Samoans HEALEY, L. A.,and JONES, K. W. (1971) Arthr. and Rheum., 14, 2836 refs

Is there a Specific Glomerulitis associated with GoutyHyperuricaemia? A Case Report (Existe-t-il une glom&rulite specifique associee i I'hyperuricemia goutteuse?A propos d'un cas) BALASSE-KETELBANT, P. (1971)Brux.-med., 51, 373 4 figs, 11 refs

Hyperuricemia, a Concomitant of Congenital Vasopressin-Resistant Diabetes Insipidus in the Adult GORDEN, P.,ROBERTSON, G. L., and SEEGMILLER, J. E. (1971) NewEngl. J. Med., 284, 1057 32 refs

The Kidney and Hyperuricaemia (Rein et hyperuric7mie)LAGRuE and MENARD (1971) Presse m6d., 79, 845

Experimental Study on Certain Methods of decreasing theUrinary Excretion of Uric Acid SORRENTINO, F. (1970)Urol. int. (Basel), 25, 444 6 figs, 12 refs

Anatomo-pathological Study of Articular Chondrocal-cinosis (ttude anatomopathologique de la chondro-calcinose articulaire) FONDIMARE, A., TALON, J.-P.,DESHAYES, P., HOUDENT, G., AUGER, P., and GRAF, R.(1971) Presse mid., 79, 707 9 figs, 10 refs

Other forms of arthritisNew Therapeutic Attempts in Behget's Disease (Report II)[In Japanese with English Summary] FUTAGAMI, T.,AOKI, K., SArro, K., SANEFUJI, M., FuJIOKA, K., KIKUCHI,K., and KATO, H. (1970) Rinsho Ganka, 24, 357 4 figs,8 refs

Fifteen cases of Behret's syndrome were followed-up forfrom 5 to 15 months after irradiation of the spleenapplied in five divided doses of 200r each completedwithin one week. The treatment resulted in definiteimprovement in the ocular as well as the extraocularsymptoms in two cases, while in three cases only theocular symptoms improved. In a further five cases therewas a slight improvement in the systemic findings but theocular symptoms persisted. In the remaining five cases,the clinical course was not affected by the therapy.A 10-year-old male child was treated by surgical

removal of the thymus. This was followed by a state ofangio-Behret syndrome and resulted in a fatal outcomedue to the Budd-Chiari syndrome. J. TSUTSUI

Cyclophosphamide Therapy of Behset's Disease GILLS,J. P. JR., and BUCKLEY, C. E., III. (1970) Ann. Ophthal.(Chicago), 2, 399 24 refs

A 15-year-old boy with Behret's disease was treated withcyclophosphamide and prednisone. The conditionresponded to this combined treatment but not to pred-nisone alone. Measurements of delayed cutaneoushypersensitivity were made using a battery of 24 commonantigens each having a known likelihood of reactivityand a defined geometrical mean response in a controlpopulation. It is claimed that the evaluation of im-munological function in this way may be a reliablemeasure of the effectiveness of therapy. N. R. GALLOWAY

Treatment of Behbet's Disease with Chlorambucil MAMO,J. G., and AZZAM, S. A. (1970) Arch. Ophthal. (Chicago),84, 446 33 refs

An encouraging report concerning a small group ofpatients who were treated with this immuno-suppressiveagent. Both the ocular and neurological features of thedisease improved. P. J. H. SELLORS

Rate of Visual Loss in Behqet's Disease MAMO, J. G.(1970) Arch. Ophthal. (Chicago), 84, 451 3 figs, 3 refs

A statistical analysis of 39 cases which showed thatvision was lost in an average of 3-36 years after the onsetof ocular disease. P. J. H. SELLORS

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Clinical Picture of the Neural Form of BehVet's Syndrome[In Japanese with English Summary] KUBOTA, Y., andTOTSUKA, S. (1970) Rinsko Ganka, 24, 389 22 refs

In fourteen (15 per cent.) of a total of 94 patients diag-nosed as cases of Behret's syndrome the conditionincluded neural symptoms. There was a preponderance ofmales over females in the ratio of 11 : 3.A clear-cut classification of the neural signs was not

possible because of the variegated clinical manifestations.In five cases, the clinical picture was similar to that ofmultiple sclerosis. Demyelinating processes in the centralnervous system were confirmed in two cases by autopsy.The prognosis for life was generally poor. Sudden

death also occurred in cases without apparent neuro-logical symptoms. J. TrsulSUI

Therapy of Gilbert Beh9et's Disease (Zur Therapie desMorbus Gilbert-Behget) HUBNER, H. (1969) Ber. dtsch.ophthal. Ges., 70, 430 1 fig., 32 refs

Cortisone used locally and systemically in high dosagein four cases had a good effect on the acute inflammatorychanges, especially in the anterior segments of the eye.Recurrences could not be prevented, however, especiallysince cortisone has to be discontinued sooner or later.Azathioprine at a low dosage of 1 * 5 to 2 *0 mg./kg. dailyhad no influence on the frequency and severity of therecurrences, which could be cut short only by high dosesof corticosteroid. The additional application of anti-biotics, antiphlogistics, gammaglobulin, etc., did notenhance the therapeutic result. L. WITTELS

Medical Treatment of Behget's Disease (Zur Frage dermedikamentosen Behandlung des Morbus Behcet)KLEINHANS, K. (1969) Ber. dtsch. ophthal. Ges., 70, 4253 figs, 8 refs

A description of a 45-year-old patient with a 16-yearhistory of Behget's disease and 8 years of observation.The disease began with bilateral periphlebitis, compli-cated later by aphthous stomatitis, ulcers of the genitalmucosa, and, finally, severe hypopyon iritis. Therapy,which consisted of sulphonamides, tetracyclines, thenadditional cortisone, and lastly all three supplemented byimmunosuppressants, had little effect on the course ofthe disease. L. WITTELS

Adamantiades Behret Syndrome (Beitrag zum Adaman-tiades-Behqet-Syndrome) RosocHowrrz, W., andMETZE, G. (1970) Klin. Mbl. Augenheilk., 157, 41418 refs

The authors observed this rare syndrome in a man whowas affected with hypopyon iritis at the age of 30 years.There were the typical eczematous changes of the skin,especially at the genitals and junctions with the mucousmembranes, further rheumatic affections of joints andmuscles, and a cardiac infarction. The retinal and irishaemorrhages after many relapses produced a cloudyvitreous cataract, and secondary glaucoma in both eyes.One eye became blind after 2 years and the other after2j years. The authors suggest that the condition may bea vascular collagenous disease. Cortisone has only asymptomatic effect. H. LYTTON

Reiter's Disease and Behfet's Syndrome (ReiterscheErkrankung, Behgetsches Syndrome MARTENET, A.-C.(1969) Ber. dtsch. ophthal. Ges., 70, 306 Bibl.

In a typical case of Reiter's disease, consisting of urethri-tis, arthritis and conjunctivitis, a virus is possibly the caus-ative organism, while mixed pictures of the disease withinvolvement of the uvea are possibly due to auto-immunological processes. A virus has not been unequivo-cally proved to be the cause of Behget's syndrome, andthe clinical picture suggests an auto-immunologicalrather than a viral genesis. L. WITrELS

Inclusion Conjunctivitis and Reiter's Syndrome in aMarried Couple. Chlamydia Infections in a Series of BothDiseases DAWSON, C. R., SCHACHTER, J., OSTLER, H. B.,GILBERT, R. M., SMITH, D. E., and ENGLEMAN, E. P.(1970) Arch. Ophthal (Chicago), 83, 300 20 refs

The report of a married couple. The wife had conjunc-tivitis and iritis. The husband had developed Reiter'ssyndrome 2 years previously. Chlamydia was demon-strated in husband and wife. It is pointed out that somepatients with Reiter's disease have keratitis and kerato-conjunctivitis. A. G. CROSS

Roentgenology of Reiter's Syndrome SHOLKOFF, S. D.,GLICKSMAN, M. G., and STEINBACH, H. L. (1970)Radiology, 97, 497 9 figs, 7 refs(Abstr. Wld Med. (1971), 45, 548)

Involvement of Veins in Behfet's Syndrome HAIM, S.,BARZILAI, D., and HAZANI, E. (1971) Brit. J. Derm., 84,238 2 figs, 17 refs

Antibacterial Activity of Synovial Fluid during Therapy ofSeptic Arthritis PARKER, R. H., and SCHMID, F. R.(1971) Arthr. and Rheum., 14, 96 2 figs, 16 refs

Suppurative Arthritis of the Hip Joint in InfancyCHACHA, P. B. (1971) J. Bone Jt Surg., 53A, 538 7 figs,11 refs

Electrocardiographic Abnormalities and Arthritis inPatients with Yersinia enterocoUtica Infection AHVONEN,P., HIISI-BRUMMER, L., and AHO, K. (1971) Ann. clin.Res., 3, 69 1 fig., 24 refs

Mycoplasma hyorhinis Swine Arthritis. I. Clinical andMicrobiologic Features BARDEN, J. A., and DECKER,J. L. (1971)Arthr. and Rheum., 14,193 4figs, 17 refsII. Morphologic Features ENNIs, R. S., DALGARD, D.,WILLERSON, J. T., BARDEN, J. A., and DECKER, J. L.(1971) Arthr. and Rheum., 14, 202 5 figs, 7 refs

Chronic Synovitis as a Manifestation of Calcium CrystalDeposition Disease MosKowrrz, R. W., HARRIS, B. K.,SCHWARTZ, A., and MARSHALL, G. (1971) Arthr. andRheum., 14, 109 4 figs, 10 refs

Posterior Synovial Leaks in Arthritis of the Knee MYLEs(1971) Proc. roy. Soc. Med., 64, 262

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Abstracts 549

Bone diseaseTreatment of Paget's Disease of Bone with MithramycinCONDON, J. R., RPITH, S. B. M., NASSIM, J. R., MILLARD,F. J. C., HILB, A., and STAINTHORPE, E. M. (1971) Brit.med. J., 1, 421 21 refs(Abstr. Wld Med. (1971), 45, 401)

Occupational Acro-osteolysis. I. An EpidemiologicalStudy DINMAN, B. D., COOK, W. A., WHITEHOUSE,W. M., MAGNUSON, H. J., and DITCHECK, T. (1971)Arch. environment. Hlth, 22, 61 1 fig., 7 refsII. An Industrial Hygiene Study COOK, W. A., GIEVER,P. M., DINMAN, B. D., and MAGNUSON, H. J. (1971)Arch. environment. Hlth, 22, 74 2 figs, 9 refsIII. A Clnical Study DODSON, V. N., DINMAN, B. D.,WHrTEHOUSE, W. M., NASR, A. N. M., and MAGNUSON,H. J. (1971) Arch. environment. Hlth, 22, 83 10 figs,10 refs(Abstr. Wld Med. (1971), 45, 541-42)

Psoriatic Acro-osteolysis Without Arthritis. A Case StudyMILLER et al. (1971) J. Bone Jt Surg., 53A, 371

Osteoporosis and the Effects of Ageing on Bone Mass inElderly Men and Women ADAMS, P., DAVIES, G. T., andSwEETNAm, P. (1970) Quart. J. Med., 39, 601 6 figs,32 refs(Abstr. Wld Med. (1971), 45, 401)

Biological Monitoring in Treatment of Systemic Osteo-porosis [In French] EISINGER, J., LAPONCHE, A. M.,MOULARD, J. C., SERRATRICE, G., and RECORDER, A. M.(1971) Rev. Rhum., 38, 265 (English Summary p. 268)7 refs

Pathological Anatomy of Osteochronosis [In French]PAGEAUT, G., GUIDET, M., CARBILLET, J.-P., PAQUETrE,J.-P., and OPPERMANN, A. (1971) Rev. Rhum., 38, 277(English Summary p. 287) 14 figs, bibl.

Marfan's Syndrome. Ophthalmological, Clinical, Bio-chemical, and Genetic Investigations (Marfan-Syndrom.Ophthalmologische, klinische, biochemische und gener-ische Untersuchungen) HEILMANN, K., SuscHKE, J., andMURKEN, J. D. (1969) Ber. dtsch. ophthal. Ges., 70, 45713 refs

Contribution to Marfan's Syndrome (Ap6rtacion alsindrome de Marfan) L6PEZ NIETO, C., and SouTroVAZQuEZ, I. (1969) Arch. Soc. oftal. hisp.-amer., 29, 102235 figs

Marfan's Syndrome (Marfan Syndrom.) HEIMiANN, K.,SuScHKE, J., and MURKEN, J. D. (1969) Ber. dtsch.ophthal. Ges., 70, 599 4 figs, 1 ref.

Congenital Ptosis, Cataract, and Marfan's Syndrome inChildren BRErr, P. R. (1969) Trans. ophthal. Soc. N.Z.,22, 149 3 figs, 2 refs

Disappearing Bone Disease with Arthropathy and SevereScarring of the Skin WHrrE (1971) J. Bone Jt Surg.,53-B, 303

Therapeutic Results of Drill Biopsy in 100 Cases ofPrimary Osteonecrosis of the Femoral Head [In French]FICAT, P., ARLET, J., ViDAL, R., Ricci, A., and FOURNIAL,J. C. (1971) Rev. Rhum., 38, 269 (English Summaryp. 275) 4 refs

Non-articular rheumatismDiagnosis and Treatment of Thoracic Intervertebral DiscProtrusions CARSON, J., GUMPERT, J., and JEFFERSON, A.(1971) J. Neurol. Neurosurg. Psychiat., 34, 68 9 figs,22 refs(Abstr. Wld Med. (1971), 45, 528)

Air Myelography and Discography in Lumbar Rheuma-tology [In French] CHAOUAT, Y., KANOVITCH, B.,LICHTENBERG, R., CAPELUS, F., and FAuREs, B. (1971)Rev. Rhum., 38, 299 (English Summary p. 304) 12 figs,7 refs

Treatment of Sciatica due to Intervertebral Disc Herniationwith Chymoral Tablets GASPARDY, G., BALINT, G.,MrrUSOVA, M., and LORINCZ, G. (1971) Rheum. phys.Med., 11, 14 16 refs

De Quervain's Disease. A Clinical Review FAImFULLand LAMB (1971) Hand, 3, 23

Polymyalgia Rheumatica (Polymyalgia rheumatica) RE-DERER, J. (1971) Med. Klin., 66, 273

Connective tissue studiesUltrastructure of Articular Cartilage in RheumatoidArthritis. A Preliminary Report MITCHELL, N., andSHEPARD, N. (1970) J. Bone Jt Surg., 52-A, 1405 20 figs,26 refs(Abstr. Wld Med. (1971), 459, 373)

Electron Microscopical Examination of the UltrasoniEffect on the Rabbits' Synovial Membrane ZICHNER, L.,and ENGEL, D. (1971) Z. ges. exp. Med., 154, 1 6 figs,6 refs

Mobility of Synovial Joints BARNETT, C. H. (1971)Rheum. phys. Med., 11, 20 6 figs, 5 refs

Synovial Structures of Normal and Rheumatoid DigitalJoints KUCZYNSKI (1971) Hand, 3, 41

Biochemical and Metabolic Abnormalities in ArticularCartilage from Osteoarthritic Human Hips, II MANKIN,H. J., DORFMAN, H., LIPPIELLO, L., and ZARINs, A.(1971) J. Bone Jt Surg., 53-A, 523 9 figs, 21 refs

Submicroscopic Effects ofHormones on Articular Cartilageof Adult Mice SILBERBERG, R., and HASLER, M. (1971)Arch. Path., 91, 241 10 figs, 11 refs

Study of the Permeability of the Articular Barrier ENGEL,D. (1971) Z. ges. exp. Med., 154, 247 4 refs

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Levels ofThree Hydrolases in Rheumatoid and RegeneratedSynovinn GRANDA, J. L., RANAWAT, C. S., andPOSNER, A. S. (1971) Arthr. and Rheum., 14, 223 6 figs,16 refs

Extrasynovial and Capsular Fat Pads on the PosteriorAspect of the Knee Joint WESTON, W. J. (1971) Brit. J.Radiol., 44, 277 12 figs, 2 refs

Connective Tissue Activation. I. The Nature, Specificity,Measrement, and Distribution of Connective Tissueactivating Peptide CASTOR, C. W. (1971) Arthr. andRheum., 14, 41 3 figs, 23 refsII. Abnormalities of Cultured Rheumatoid Synovial CellsCASTOR, C. W. (1971) Arthr. and Rheum., 14, 55 5 figs,27 refs

Relationship Between the Anti-in tory and IrritantProperties of Inflammatory Exudate ATKINSON, D. C.,and HICKS, R. (1971) Brit. J. Pharmacol., 41, 480 4 figs,15 refs

LE Cells in Biopsies of Positive Deoxyribonucleic AcidSkin Tests ORES, R. O., and MANDEL, E. H. (1971)Brit. J. Derm., 84, 217 4 figs, 17 refs

Joint Lubrication with Artificial Lubricants RADIN,E. L., PAUL, I. L., and WEISSER, P. A. (1971) Arthr. andRheum., 14, 126 17 refs

Studies of the Autoantibody Nature of Collagen Anti-bodies and their Occurrence in the Synovial Fluid ofPatients with Rheumatoid Arthritis (Untersuchungenuiber die Autoantikorpereigenschaft von Kollagenanti-korpern und ihr Vorkommen in der Synovia von Patientenmit rheumatoider Arthritis) STEFFEN, C., CARMANN, H.,SCHUSTER, F., TAUSCH, G., BOSCH, J., and FREILINGER, G.(1971) Z. Rheumaforsch., 30, 92 16 refs

Immunoglobulins G, M, and A in Synovial Fluid [InFrench] VEYS, E., DE lOORE, J., and MIELANTS, H.(1971) Rev. Rhum., 38, 289 (English Summary p. 296)16 figs, 24 refs

Pararheumatic (Collagen) DiseasesJuvenile Dermatomyositis HILL, R. H., and WOOD,W. S. (1970) Canad. med. Ass. J., 103, 1152 2 figs, 21 refs

The authors, both on the staff of the University of.British Columbia and Vancouver General Hospital,,discuss the clinical aspects of thirteen cases of juvenile,dermatomyositis seen over a 10-year period from theGreater Vancouver Hospital district, an area in whichabout 900,000 people live and where about 250,000 are-.under 15 years of age.

The clinical features of the cases are discussed in somedetail and the effect of treatment by oral prednisone andthe results are assessed. Two of the children died; one,in whom the dermatomyositis was extremely acute, died

from respiratory infection; the second died possibly froma complication of corticosteroid treatment, but noconclusive cause of death was established. Apart fromthese cases, the patients were followed-up for 3 to 8 yearsfrom the onset of their disease. Four case histories arediscussed and the rest illustrated in tabular form.A review of the literature is given. In this the high

incidence of calcinosis in children is noted, as is the factthat this would appear to carry a favourable prognosisprobably on account of the long-standing nature of thedisease. The incidence of malignant disease in these casesis shown to be significantly lower than in adults and theprognosis better. Laboratory investigations, according tothe sources quoted, rarely assist in diagnosis. Referenceis made to serum muscle enzymes, particularly SGOTlevels. The use of methotrexate is referred to, but the twopatients receiving it failed to show benefit.

It is observed that the disease is extremely variable,making it difficult to draw valid conclusions from aparticular series. The authors are particularly impressedby the prompt improvement in muscle strength andconcurrent lessening in muscle pain when large doses ofsteroids are given.

This is a useful article, although the list of referencescited by the authors omits some of the most importantand thoughtful articles on the subject. No reference ismade to the importance of creatinine metabolism.

0. L. S. SCOTT

Spectrum of Aging Changes in Temporal Arteries LIE,J. T., BROWN, A. L., JR., and CARTER, E. T. (1970)Arch. Path., 90, 278 13 figs, 30 refs

Biopsy of temporal arteries has become an importantdiagnostic measure in the diagnosis of temporal arteritisand polymyalgia rheumatica. These conditions occur inthe elderly, so that one must be aware of normal ageingchanges in the vessels. In the present study 150 temporalarteries were taken from random autopsies and age-categories defined.

Infantile pattern: no intima, thick unblemished internalelastic lamina (IEL).

Youth pattern: distinct intima, less than half thicknessof media, commencing reduplication of largely intactIEL.

Adult pattern: diffuse intimal thickening, attaining orexceeding that of the intima, increase of intimal andmedial collagen, fragmentation and fraying of IEL.

Senile pattern: intima often twice as thick as media,gross disruption of IEL, degeneration of elastic fibres.No lipid material was demonstrated in any of the arter-

ies; calcification was found in one-fifth of arteries frompatients aged over 50. None of the arteries showedthrombosis or the giant-cell reaction characteristic ofactive temporal arteritis. It was considered that theresidual changes of temporal arteritis (which may persistfor many years) were sufficiently different from theordinary changes of senescence to enable a distinction tobe made, the single most helpful feature being a differencein the zonal arrangements of intimal proliferation.

This paper with its illustrations should be seen by allhistologists and clinicians interested in temporal arteritis.

J. T. SCOTT

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Temporal Arteritis. II. Electron-microscopic Study onConsecutive Biopsies KuwABARA, T., and REnmcKE,R. D. (1970) Arch. Ophthal. (Chicago), 83, 692 8 figs,31refsElectron microscopic studies of biopsies in temporalarteritis showed that in the early stages the smoothmuscle was involved and an inflammatory reaction waspresent. After 6 weeks of treatment the artery showedfibrosis of the muscle wall and fragmentation of theelastica, while the inflammatory signs were considerablyreduced. BARRI JAY

Temporal Arteritis in Ophthalmology. Diagnosis andTreatment (La arteritis temporal en oftalmologia:diagn6stico y tratamiento) HONRUBIA, F. M., andPILAR GRUALBO, M. (1969) Arch. Soc. oftal. hisp.-amer.,29, 897 5 figs, 33 refsSince the ophthalmic signs are often the first to benoticed in temporal arteritis, the importance of the role ofthe ophthalmologist is emphasized. This is a goodbibliographical review of the disease. Mention is madeof Burian's electroretinographic findings of anomalouswaves which he considers to be typical of temporalarteritis.The authors comment on the important role of the

corticosteroids in the treatment and prognosis of thedisease. The beneficial effect of retrobulbar cortisoneacetate is mentioned. Systemically, intramuscular ACIHadministration followed, when the diagnosis has beenconfirmed, by prednisone administration is recom-mended. Anticoagulants and intermittent oxygen inhala-tions are beneficial; vasodilators are contraindicated.

ALFREDO ARRUGA

Eyeball Bruits in Temporal Arteritis GILBERT, G. J.(1970) Dis. nerv. Syst., 31, 130A case report. Bilateral bruits were found in a managed 76 who had episodes of amaurosis and a raisederythrocyte sedimentation rate. The bruits ceased onsteroid therapy. A. S. MUSHIN

Polyarteritis and Intrarenal Artery AneurysmsDORNFIELD, L., LECKY, J. W., and PETER, J. B. (1971) J.Amer. med. Ass., 215, 1950 4 refs, 5 figs

Involvement of the Eye in Inflammatory Systemic Diseasesof the Connective Tissue (Round Table Discussion II)(Augenbeteiligung bei entzundlichen Systemerkrankun-gen des Bindegewebes) B6KE, W. (Chairman) (1969) Ber.dtsch. ophthal. Ges., 70, 396 15 figs, bibl.

Early Fingertip Changes in Scleroderma YUNE, H. Y.,Vix, V. A., and KLAITE, E. C. (1971) J. Amer. med. Ass.,215, 1113 3 figs, 4 refs(Abstr. Wld Med. (1971), 45, 525)

Scleroderma and the Subcutaneous Tissue FLEISCH-MAJER, R., DAMIANO, V., and NEDWICH, A. (1971)Science, 171, 1019 3 figs, 5 refs

Unique Chest Roentgenogram in Scleroderma ZUCKNER,J., and MARTIN, J. (1971) Amer. J. Roentgenol., 111, 6052 figs

Renal Immune Deposits in Scleroderma McGIvEN, A. R.,DE BOER, W. G. R. M., and BARNETr, A. J. (1971)Pathology, 3, 145 5 figs, 10 refs

Immunological Aspects of Systemic Sclerosis CURRE,S., SAUNDERS, M., and KNowLEs, M. (1971) Brit. J.Derm., 84, 400 6 figs, 33 refs

Progressive Systemic Sclerosis DuBoIs, E. L., CHANDOR,S., FRIou, G. J., and BISCHEL, M. (1971) Medicine(Baltimore), 50, 199 17 figs, 43 refs

Sclerodermal Hyalopathy GARTNER, J. (1970) VirchowsArch., Abt. A., 350, 166 8 figs, 25 refs

Symposium on Scleroderma (1971) Mayo Clin. Proc., 46,83-134 (9 articles on scleroderma)

Sjogren's Syndrome associated with Vitamin B12 De-ficiency [In English] WEGELIUS, O., FYHRQUIST, F.,and ADNER, P.-L. (1970) Acta rheum. scand., 16, 18423 refs(Abstr. Wid Med. (1971), 45, 422)

'Sicca Complex' in Liver Disease GOLDING, P. L.,BOWN, R., MASON, A. M. S., and TAYLOR, E. (1970)Brit. med. J., 4, 340 2 figs, 18 refs(Abstr. Wld Med. (1971), 45, 404)

Sjogren's Syndrome studied by Fluorescent AntibodyTechnique [In Japanese with English Summary] INUKAI,K. (1970) Rinsho Ganka, 24, 1251 3 figs, 3 refs

Treatment of the Gougerot-Sjogren Syndrome (Traite-ment du Syndrome de Gougerot Sjogren) BONNET, M.(1970) Ann. Oculist. (Paris), 203, 775 12 refs

Problems in the Treatment of the Neurological andPsychiatric Manifestations of Dissinated Lupus Ery-thematosus [In French] CORVOL, P., LAGRUE, G.,MARTEAU, R., and MILLIEZ, P. (1971) Sem. Hop. Paris,47, 1275 (English summary, p. 1279) 25 refs

Elective Involvement of the CNS in Lupus Erythematosus[In German] RompF, G. (1971) Fortschr. Neurol.Psychiat., 39, 229 6 figs, bibl.

Oral Lupus Erythematosus EDWARDS and GAYFORD(1971) Oral Surg., 31, 332

Laboratory Abnormalities in the Diagnosis and Manage-ment of Lupus Erythematosus RowEilL, N. R. (1971)Brit. J. Derm., 84, 210 10 refs

Lupus Erythematosus Panniculitis (Profundus) TUFFAN-ELLI (1971) Arch. Derm., 103, 231

Deep Marginal Corneal Ulcer in Lupus Erythematosus(Tiefes Hornhautrandgeschwuir bei Erythematodes)MEHRLE, G. (1969) Ber. dtsch. ophthal. Ges., 70, 1664 figs, 15 refs

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Inhibition of the L.E.-Ceil Phenomenn In Patients withHepatitis [In German] HOLTZ, G., and SCHUBERT,J. C. F. (1971) K1in. Wschr., 49, 660 1 fig., 2 refs

Antibodies to Viral Antigens in Systemic Lupus Erythe-matosus BLAINE HOLLINGER, F., SHARP, J. T., LIDSKY,M. D., and RAWLS, W. E. (1970) Arthr. and Rheum., 14,1 35 refs(Abstr. Wld. Med. (1971), 45, 525)

Neurological Involvement in Systemic Lupus Erythe-matosus TAY, C. H., and KHoo, 0. T. (1971) Singa-pore med. J., 12, 18 46 refs

Systemic Lupus Erythematosus presenting as Subarach-noid Haemorrhage and Space Occupying Lesion CASEYand SYMON (1971) Brit. J. Derm., 84, 157

Systemic Lupus Erythematosus induced by PsychotropicDrugs FABIUS, A. J. M., and GAULHOFER, W. K. (1971)Acta rheum. scand., 17, 137 1 fig., 9 refs

Lymphocyte Transformation induced by AutologousPlatelets in a Case of Thrombocytopenic Purma Pus-SENS, W. F., WYBRAN, J., MANASTER, J., and STRuCK-MANS, P. A. (1970) Blood, 36, 421 3 figs, 14 refs(Abstr. Wld Med. (1971), 45, 424)

Renal Involvement in Purpwa Rheumatica in Adults.Renal Biopsy in 21 Cases. Value of ImmunofluorescenceStudy of the Glomeruli (Atteinte r6nale du purpurarhumatolde chez l'adulte. ttude de 20 biopsies r6nales.Int6r&t de 1'examen glom6rulaire en imunofluorescence)FILLASTRE, J.-P., MOREL-MAROGER, L., DUCROISET, B.,and RICHET, G. (1970) Presse med., 78, 2375 2 figs,18 refs(Abstr. Wld Med. (1971), 45, 476)

Schonlein-Henoch Purpua in the Adult. A Study of 77Adults with Anaphylactoid or Schinlein Henoch PurpuraCREAM, J. J., GUMPEL, J. M., and PEACHEY, R. D. G.(1970) Quart. J. Med., 39, 484 7 figs, bibl.(Abstr. Wld Med. (1971), 45, 455)

Immunology and serologyConversion of Soluble Immune Complexes into Comple-ment-fixing Aggregates by IgM-Rheumatoid FactorTESAR, J. T., and SCHMID, F. R. (1970) J. Immunol., 105,1206 3 figs, 34 refs

This study comes from the section of Arthritis andConnective Tissue Diseases of North Western University,Chicago. The rheumatoid factor (RF) employed wasobtained from high titre sera by elution from an insolubleabsorbent of human IgG cross-linked by bis-diazotizedbenzidine. The immune complexes were prepared frombovine serum albumin (BSA) and rabbit anti-BSA (IgG).The results clearly showed that complexes formed at

near equivalence of antigen and antibody, which fixmaximum amounts of complement (C), give someincreased fixation when RF is previously bound to thecomplexes. Complexes formed at higher ratios of Ag to

Ab, which alone fix only small amounts of C, give evengreater enhancement of fixation when RF is previouslybound. By the use of anti-BSA serum treated withmercaptoethanol, which considerably impairs its abilityto fix C but without interfering with the ability of itscomplex with BSA to bind RF, the authors also showedthat the binding of C by complexes of antigen, antibody,and RF is mainly due to the binding of the C to theRF component.Although these investigations were carried out entirely

in vitro, the results support the view that RF is potentiallypathogenic rather than protective, in so far as it canincrease the binding, and hence the activation, of the Csystem by soluble immune complexes. L. E. GLYNN

Antinuclear Anffbodies in Systemic Ipus ErythematosusBENSON, M. D., and COHEN, A. S. (1970) Ann. intern.Med., 73, 943 6 figs, 19 refs

An indirect immunofluorescent method of detectingserum antinuclear antibodies is compared with anindirect method in which the anti-human IgG waslabelled with horseradish peroxidase (Type II) byglutaraldehyde conjugation. For fluorescence, cryostatsections of mouse liver were fixed in 40:60 acetone/ethanol, dried, treated with patients' sera (neat-i :128),washed, dehydrated in graded alcohols (an unusual step)and then stained.For horseradish peroxidase (HRP), cryostat sections of

mouse liver were briefly formalin-fixed, treated withpatients' sera, washed, incubated with HRP-labelledanti-IgG, washed again, and then incubated with 3,3'-diaminobenzidine and H202. The brown colour of theinsoluble reaction product was enhanced with osmiumtetroxide and the preparation dehydrated, cleaned, andmounted. With positive sera, the brown nuclei weredistinct, with negative sera the nuclei were clear. Serafrom patients with systemic lupus erythematosus,rheumatoid arthritis, progressive systemic sclerosis, anda range of connective tissue diseases were tested forantinuclear antibodies by both methods, and close, butnot absolute, comparability was demonstrated, both forpositivity and for titre. The HRP method was thought tohave some advantages over immunofluorescence, viz:reproducibility, ease of standardization, lack of non-specific staining, and lack of need for special microscopeillumination. E. J. HOLBOROW

Apparent False-positive Reactions in a Serological Test forSyphilb and Presence of Antinuclear Factor in Hybrids ofNZB and A/J Mice NoluNs, L. C., LOGAN, L. C., andLANTZ, M. A. (1970) J. Immunol., 105, 1108

This paper from the Venereal Disease Research Labora-tory, Atlanta, Georgia, describes the finding of biologicalfalse positive reactions for syphilis (BFP) in F1 hybridsof New Zealand Black and A/J mice. The 'rapid plasmareagin' (RPR, 18mm. circle) card test was used on freshserum. This has a sensitivity for cardiolipin antibodiescomparable to the VDRL agglutination test. Specifictreponemal antibodies as detected by FTA-ABS wereabsent in these animals. 32y3 per cent. of male hybridshad cardiolipin antibodies and only 2 per cent. offemales. This compares with 2 - 5 and 3 * 7 per cent.

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respectively in the pure NZB strain. In many instances apositive RPR test was associated with ANA in theserum. Chronic BFP reactions are known to occurmainly in female patients with collagen disorders andgenetic factors are probably involved in humans as inthese mice. NZB hybrids of several kinds developfeatures of collagen disorders, and studies of auto-antibodies including BFP reactions should prove auseful model for the human diseases. DEBORAH DONIACH

Erythrocyte Sedimentation Rate Pattern in UveitisFAJARDO, R. V., and PARIAL, A. T. (1970) Philipp. J.Ophthal., 2, 55 14 refs

The erythrocyte sedimentation rate was determined in107 active endogenous cases of uveitis in the uveitisclinic of the Philippine General Hospital, and it wasfound to be elevated in 78 cases (72-9 per cent.). Therewas no significant difference between the granulomatousand non-granulamatous cases. The ESR, however, wassignificantly elevated in the anterior type of uveitis andin patients whose aetiology was related to a generalizedcondition such as tuberculosis or rheumatoid arthritis.

R. B. ESPIRITU

Effect of Aging on Human Serum Immunoglobulin Con-centrations BUCKLEY, C. E., III, and DORSEY, F. C.(1970) J. Immunol., 105, 964 17 refs(Abstr. Wld Med. (1971), 45, 375)

Microscope Slide Electrophoresis of Serum LipoproteinsIn Agarose Gel ELPHICK, M. C. (1971) J. clin. Path., 24,83 2 figs, 7 refs

Serum Protein Concentrations in Normal ChildrenABRAB s, B. (1971) Clin. Sci., 40, 67 1 fig., 6 refs

Lysis of Erythrocytes by Complement in the Absence ofAntibody GOTZE, O., and MURLLER-EBERHARD, H. J.(1970) J. exp. Med., 132, 898 9 figs, 32 refs(Abstr. Wld Med. (1971), 45, 370)

Complement System in Rheumatoid Synovitis. II. Intra-cytoplasmic Inclusions of Immunoglobulins and Comple-ment BRrrrON, M. C., and SCHUR, P. H. (1971) Arthr.and Rheum., 14, 87 5 figs, 34 refs

Interaction of Rheumatoid Factor with Infectious HerpesSimplex Virus-Antibody Complexes AsHE, W. K.,DANIELS, C. A., ScoTT, G. S., and NOTKINS, A. L. (1971)Science, 172, 176 13 refs

Rheumatoid Arthritis with Dissociated Serology (InFrench) DELBARRE, F., SAPORTA, L., PELTIER, A.,BROUELHET, H., and PLANQUE, B. (1971) Sem. Hop.Paris, 47, 1547 (English summary, p. 1558) 1 fig.,5 refs

Rheumatoid Factor in the Aged (In French) VERDIERJ.-M., PHELIP, X., and CABANEL, G. (1971) J. MMd.Lyon, 52, 703

Interpretation and Value of Slide Tests in the Detection ofRheumatoid Arthritis (In English) VANSLYPE, J.,VERSTRAETE, J., and TRIsTMANS, E. (1971) J. belge Rhum.Mid. phys., 26, 12 9 refs

Cryoglobulin and Rheumatoid Factor in Primary andSecondary Syphilis PERROT, H., THIVOLET, J., andFRADIN, G. (1971) Presse mid., 79, 1059 6 refs

Antinuclear Antibodies, Rheumatoid Factor, and C-Reactive Protein in Serum of Normal Women using OralContraceptives KAY, D. R., BOLE, G. G., JR., andLEDGER, W. J. (1971) Arthr. and Rheum., 14, 239 25 refs

Changes in C'3 (B,A-Globulin) Concentration in Inflam-matory Rheumatic Diseases (Das Verhalten der C'3-Kon-zentration (Beta-la-Globulin) bei entzundlich rheuma-tischen Erkrankungen) KLEIN, G. (1971) Z. Rheuma-forsch., 30, 104 16 refs

Presence of a Group A Variant-like Antigen in Strep-tococci of Other Groups with Special Reference toGroup N ELLIOTT, S. D., HAYWARD, J., and LIu, T. Y.(1971) J. exp. Med., 133, 479 6 figs, 16 refs

Immunoglobulin G Subclasses of Antinuclear Antibodiesand Renal Deposits. Comparison of Systemic LupusErythematosus, Drug-induced Lupus, and RheumatoidArthritis KACAKI, J. N., CALLERAME, M. L., BLOMGREN,S. E., and VAUGHAN, J. H. (1971) Arthr. and Rheum., 14,276 1 fig., 20 refs

Selective IgA Deficiency AMMANN, A. J., and HONG, R.(1971) Medicine (Baltimore), 50, 223 5 figs, 92 refs

Pathogenesis of Autoimmunity in New Zealand Mice.III. Factors influencing the Formation of AntWnucleic AcidAntibodies STEINBERG et al. (1971) Immunology, 20, 523

Antibody Plaque-forming Cells in Mice Immunized withHuman Gamma Globulin. I and II HEGE and EPsTEIN(1971) J. Immunol., 106, 786 and 793

Radioimmunoassay of Plasma ACTH in Intact RatsMATSUYAMA et al. (1971) Endocrinology, 88, 692

Bioassay and Radioimmunoassay of Plasma ACTH inAdrenalectomized Rats MATSUYAMA et al. (1971)Endocrinology. 88, 696

Intra-articular 5-fluorouracil in Antigen-induced ArthritisSTEINBERG, M. E., MCCRAE, C. R., BERSELLI, R. A., andCRAM, B. (1971) J. Bone Jt Surg., 53-A, 514 5 figs,33 refs

Papain-induced Degenerative Arthritis of the Hip inRabbits BENTLEY (1971) J. Bone Jt Surg., 53B, 324

Relationships between Relative Binding Affinity andElectrophoretic Behavior of Rabbit Antibodies to Strep-tococcal Carbohydrates EIcHMANN, K., and GREEN-BLATr, J. (1971) J. exp. Med., 133, 424 9 figs, 26 refs

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Biochemical studiesIntrafolUcular Amyloid in Primary HyperparathyroidismLEEDHAM, P. W., and POLLOCK, D. J. (1970) J. clin. Path.,23, 811 7 figs, 37 refs(Abstr. WId Med. (1971), 45, 371)

Multiple Amyloid Tumors of the Lung. A Case ReportTEIXIDOR and BACHMAN (1971) Amer. J. Roentgenol.,111, 525

Metabolis of Fibrinogen in Patients with RheumatoidArthritis and in a Control Group ANDERSEN, R. B., andFRIS, TH. (1971) Acta rheum. scand., 17, 94 2 figs,20 refs

Fibrinogen Degradation Products in Serum and Urine ofPatients with Systemic Lupus Eryteatosus. Relation toRenal Disease and Pathogenetic Mechanism KANYEREzi,B. R., LWANGA, S. K., and BLOCH, K. J. (1971) Arthr. andRheum., 14, 267 1 fig., 37 refs

Release ofDNA into SerUm and Synovial Fluid HUGHES,G. R. V., COHEN, S. A., LIGHTOOT, R. W., jR., MELTZER,J. I., and CHTIAN, C. L. (1971) Arthr. and Rheum., 14,259 3 figs, 21 refs

Transformation of Cortisol in Rbeumatoid SynovialTissue in vitro EL ArrAR, T. M. A. (1970) J. clin.Endocr., 31, 334 1 fig., 2 refs

Morpbology of Acid Mucosubstances In LeukocytesSticking to Endothelium in Acute Infa on JONES(1970) Lob. Invest., 23, 606

Charcter of Anti-DNA Antibodies in Systemic LupusErythematosus COHEN et al. (1971) Clin. exp. Immunol.,8,551

Virus-like Structures in Leucocytes of the PeripheralBlood in Systemic Lupus Erythematosus [In German]MULLER-HERMELINK, H. K., LENNERT, K., and SCHLAAK,M. (1971) Klin. Wschr., 49, 661 1 fig., 10 refs

Study of Blood Lympbocytes in Systemic Lupus Erythe-matosus (Etude des lymphocytes du sang au cours de lamaladie lupique) DELBARRE, F., POMPIDOu, A., KAHAN,A., BROULHET, H., G6, A. LE, and AMOR, B. (1971)Path. et Biol., 19, 379 4 figs, 26 refs

Studies on Chemical Composition of Menisci from theHuman Knee-Joint PETERS and SMnLIE (1971) Proc.roy. Soc. Med., 64, 261

Effect of Gold on Collagen Metabolism in the Skin andBones ofthe Rat (Der Einfluss von Gold aufden Kolla gen-stoffWechsel von Haut und Knochen der Ratte) BURK-HARDT, H., ROMMEL, K., BURKHARDT, F., and WELTER,D. (1971) Z. Rheumaforsch., 30, 98 4 figs, 16 refs

"8F and 86Sr Scntimetry in the Study of Primary Arthro-

pathies MuHEIM, G., and CRUTCHLOW, W. P. (1971)Brit. J. Radiol., 44, 290 5 figs, 15 refs

Avoiding False-Positive Joint Scans by the Use of LabeedAlb_S COHEN, M. B., and LORBER, A. (1971)Arthr. and Rheum., 14, 32 4 figs, 10 refs

Isotope Studies in Normal and Diseased Knee Joints:99mTC Uptake related to Cinical t and toSynovial Perfusion measured by the 153Xe ClearanceTechnique DICK, W. CARSON, et al. (1971) Clin. Sci.,40, 327

TherapyOccurrence, Immunoglobulin Pattern, and Specificity ofAntinuclear Antibodies in Sera of Procaine-amide-treated Patients KLAJMAN, A., CAMIN-BEIsKY, N.,KiMcm, A., and BEN-EFRAIM, S. (1970) Clin. exp.Immunol., 7, 641

This study from the Tel-Aviv Medical School, Israel,describes the development of antinuclear antibodies(ANA) in 31 of fifty patients treated with procainamidefor 2 to 16 months. Most of the patients were malessuffering from coronary heart disease and auricularfibrillation and none had previous histories of rheumaticdisorders or positive ANA. The antibodies developedgradually to titres varying between 1:10 and 1:2,000,about half the cases having titres greater than 1:100, andwere of IgG, IgM and occasionally IgA classes. In fivepatients with high titres, LE cells were also found, andthere was a clinical syndrome resembling lupus erythe-matosus, one case having a rash, another pleurisy, andfour a fleeting polyarthritis. The nuclear fluorescencecould be inhibited with nucleohistone in eleven out of 23sera having high titres and most of the reactions wereunaffected by preincubation with DNA, whether nativeor denatured, or by procaine amide or the drug coupledto DNA. It was concluded that this drug may behavelike a hapten, the change in antigenicity of nuclearcomponents leading to antibody formation, or that PrAleads to release of tissue components or increases nonspecifically the degree of immune response to weakantigens. DEBORAH DONIACH

Recovery of Hypothahmo Pituitary-Adrenal Function inthe Rat after Prolonged Treatment with BetamethasoneHODGES, J. R., and MITCHLEY, S. (1970) Brit. J. Pharma-col., 40, 732

This paper reports the results of studies on the effects oforal corticosteroids upon the cerebro-hypothalamo-pituitary adrenal (CHpA) axis and growth rates ofSprague-Dawley rats. Two concentrations (high and lowdose) of betamethasone were given orally for differenttime periods (2 and 7 weeks), both regimens ultimatelyensuring the ingestion of approximately 450 uG./100 g.Measurements performed were growth rates (ingrammes), adrenal weight, circadian rhythm, plasmacorticosterone increments after submaximal ether vapouror tetracosactrin adrenal stimulation, and adrenalcorticosterone production in vitro.Growth rates, which were reduced by the low dose

regimen and reduced further by the high dose, recoveredrapidly on cessation of treatment. Adrenal weights werereduced only by the high dose regimen and they returned

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to normal within 4 days after withdrawal. Circadianrhythm was suppressed by high-dose treatment but alsoreturned to normal within 4 days. High dose treatmentabolished and low dose reduced the plasma corti-costerone response to adrenal stimulation but this againreturned to normal within 4 days. Corticoidogenesis waslikewise suppressed with low-dose treatment and returnedrapidly to normal. 5 per cent. of the animals died,usually of infection.The authors make the point that CHPA axis recovery

was rapid. They suggest that ACTH secretion occurssoon after withdrawal and perhaps before the ability ofthe adrenal cortex to respond to ACTH has recovered.No relationship between CHPA axis suppression andtotal corticosteroid dose was detected; the duration andregimen of treatment seems to be more important.

W. CARSON DICK

Recovery of Adrenocortical Function during Long-termTreatment with Corticosteroids WESTERHOF, L., VANDITMARS, M. J., DER KINDEREN, P. J., THIJSSEN, J. H. H.,and SCHWARZ, F. (1970) Brit. med. J., 4, 534 6 figs,19 refs(Abstr. Wld Med. (1971), 45, 483)

Clinical Evaluation of an Oral Analgesic, Z.424, inPatients with Chronic Pain MARTNETrI, L., LODOLA,E., MONAFO, V., and FERRARI, V. (1970) J. clin. Phar-macol., 10, 390 2 figs, 10 refs(Abstr. Wid Med. (1971), 45, 384)

Double-blind Clinical Trial of the Analgesic Effects ofPhenazocine Hydrobromide (Narphen) compared withMorphine Sulphate in Patients with Acute Abdominal PainHOPTON, D. (1971) Gut, 12, 51 10 refs(Abstr. Wld Med. (1971), 45, 384)

Silicone Injection of Joints. Experimental and ClinicalTrials HELAL, B., COZEN, L., and KRAMER, L. (1970)Int. Surg., 54, 317 3 refs(Abstr. Wld Med. (1971), 45, 384)

Effect of Non-steroidal Anti-inflammatory Drugs onOsteoarthritis of the Knee. With Special Reference toPSP Clearance as an Indicator [In English] AsAI, H.,and NAKAmuRA, R. (1970) Acta rheum. scand., 16, 2315 figs, 14 refs(Abstr. Wld Med. (1971), 45, 525)

Allopurinol in Psoriasis [In English] VIGLIOGLIA, P. A.,PLANTE, G. E., VIGLIOGLIA, J., and SARACENO, E. F.(1970) Dermatologica (Basel), 141, 203 15 refs(Abstr. Wld Med. (1971), 45, 530)

Impairment of Drug Metabolism in Man by Allopurinoland Nortriptyline VESELL, E. S., PASSANANTI, G. T., andGREENE, F. E. (1970) New Engl. J. Med., 283, 14843 figs, 20 refs(Abstr. Wld Med. (1971), 45, 482)

Nonsteroid Anti-inflammatory Drugs. Value of an Equi-molecular Salt of Phenylbutazone and Piperizine in theTreatment of the Rheumatic Diseases (A propos desanti-inflammatoires non steroides. Interet du sel equi-mol6culaire de ph6nylbutazone et de piperazine dans letraitement des maladies rhumatismales) DELBARRE, F.(1971) Sem. Hop. Paris, 47, 231 1 fig., 10 refs

Drug Treatment of Rheumatic Disorders in GeneralPractice. A Comparative Study of Aspirin and an Alkali-Phenylbutazone Preparation LEwIs-FANING, E., andFOWLER, P. D. (1971) Brit. J. clin. Pract., 25, 123 1 fig.,10 refs

Treatment of Rheumatoid Arthritis with Cytotoxic andAntimetabolic Drugs CuRREY, H. L. F. (1970) Trans.St. John's Hosp. derm. Soc. (Lond.), 56, 117 1 fig.,14 refs(Abstr. Wld Med. (1971), 45, 524)

Mechanism of the Inhibitory Action of Indomethacin onSmooth Muscle NORTHOVER, B. J. (1971) Brit. J.Pharmacol., 41, 540 7 figs, 24 refs

Oral Azapropazone Treatment in Extra-articular Rheu-matism (Perorale Azapropazonbehandlung beim Weich-teilrheumatismus) MENNET, P., OLBRICH, E., ULRYCH,I. and J., and SAUSGRUBER, H. (1971) Schweiz. med.Wschr., 101, 647 2 refs

Study of Niflumic Acid in Twenty Cases of InflammatoryRheumatism treated with Corticosteroids (Etude del'acide niflumique dans 20 cas de rhumatisme inflam-matoire traites aux corticoldes) ROSSUM, P. E. VAN(1971) Brux.-med., 51, 387 16 refs

Systematic Study of Niflumic Acid in RheumatologicalPractice [In French] COLINET, E., FAMAEY, J. P., andBAUDUIN (1971) J. belge Rhum. Mid. phys., 26,21 3 figs,19 refs

Cyclophosphamide Treatment of Rheumatoid Arthritis[In German] RAu, R. (1971) Dtsch. med. Wschr., 96,992 (English summary, p. 1001) 5 figs, 41 refs

Treatment of Rheumatoid Arthritis with Cyclophosphamide(Endoxan) [In Danish] JARL0V, N. V., and S0RENSEN,K. (1971) Ugeskr. Laeg., 133, 587 12 refs

Long-Term Altermating Corticotherapy (Corticotherapiealternme de longue duree) GALMICHE, P. (1971) Rhum-atologie, 23, 17 1 fig.

Comparison between Epidural Anaesthesia with andwithout Corticosteroids in the Treatment of SciaticaBELIVEAU, P. (1971) Rheum. phys. Med., 11, 40 1 fig.,14 refs

Physiologic Availability of Solid Dosage Forms of Phenyl-butazone. I and II VAN PETrEN, G. R., FENG, H.,WrrHEY, R. J., and LErrAU, H. F. (1971) J. clin. Phar-macol., 11, 177 and 187 I. 2 figs, 17 refs II. 5 figs,15 refs

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Medical Management of R toid Arthtids NEu-STADT, D. H. (1971) J. Albert Einstein med. Centre, 19, 252 refs

Physical Measures in Rheumatoid Arthitis GLASS,D. D. (1971) J. Albert Einstein med. Centre, 19, 32

Functional Neck Pain in Spa Practice (Les cervicalgiesfonctionnelles en pratique thermale) FABRE, M. (1971)Rhumatologie, 23, 19

Indication for Additional Tuberculostatic Therapy inCollagen Diseases [In German] LANGER, H., ScHWENKE,R., and HE ELMANN, G. (1971) Z. ges. inn. Med., 26,289 2 figs, 35 refs

Assessment of Drug-induced Occult Bleeding CUDDIGAN,J. H. P., SWEETLAND, C., and CROFr, D. N. (1971)Rheum. phys. Med., 11, 36 2 figs, 5 refs

Steroid Myopathy YATES, D. A. H. (1971) Rheum. phys.Med., 11, 28 3 figs, 23 refs

Human Trbecular Meshwork in Corticosteroid-inducedGlaucoma KAYEs, J., and BECKER, B. (1969) Trans.Amer. ophthal. Soc., 67, 339 10 figs, 8 refs

Pathogenesis of Steroid-induced Glaucoma (Sulla pato-genesi del glaucoma da corticosteroidi) SLiATO, F.(1969) Minerva oftal., 11, 160 2 figs, 9 refs

Corticosteroid-induced Glaucoma and Cataracts in Con-tact Lens Wearers BURDLE, R. M., and BECKER, B.(1970) J. Amer. med. Ass., 213, 2075 4 figs, 14 refs

Cortisone and Ocular Tension (Cortisone et tonusoculaire) LLOUQUET, J.-L. (1971) Ann. Oculist. (Paris),203, 673 6 refs

Systemic Drugs, Steroids, and Vision GRANT, W. M.(1970) Sight-sav. Rev., 40, 19 19 refs

Corticosteroid-induced Ocular Hypertension in Pseudo-exfoliation of Lens Capsule GILmIES, W. E. (1970)Amer. J. Ophthal., 70, 90 15 refs

Electroretinography in Patients with Connective TissueDiseases treated with Hydroxychloroquine SASSAMAN,F. W., CASSIDY, J. T., ALPERN, M., and MAASEIDVAAG, F.(1970) Amer. J. Ophthal., 70, 515 4 figs, 19 refs

Differences in the Retinotoxic Action of Chloroquine andPhenothiazine Derivatives GREGORY at al. (1970)J. Path., 102, 139

Prelminary Stady of the Effect of Chloroquine on the RatRetina HODoKINSON, B. J., and KoLB, H. (1970) Arch.Ophthal. (Chicago), 84, 509 7 figs, 15 refs

Irreversibl Lysosomal Damage duced by Chloroquine inthe Retinae of Pigmented and Albino Rats ABRAHAM, R.,and HENDY, J. R. (1970) Exp. molec. Path., 12, 18522 figs, 23 refs

Accmulation of Chorio-Retinotoxic Drugs in the FoetalEye ULLBERG, S., LINQUIST, N. G., and SJmsTAND,S. E. (1970) Nature (Lond.), 227, 1257 2 figs, 10 refs

Effect of Buffered and Unbuffered Aspirin on Gastric pHmeasured by a pH-sensitive Telemetering Capsule [InEnglish] RUSSELL, R. I., and GOLDBERG, A. (1970)Scand. J. Gastroenterol., 5, 675 19 refs(Abstr. Wld Med. (1971), 45, 378)

Role of Gastric Acid in Aspirin-induced Erosive GastritisGoTrscHALK, A., and MENGUY, R. (1970) Proc. Soc. exp.Biol. (N. Y.) 3 figs, 5 refs(Abstr. Wld Med. (1971), 45, 498)

Hypersensitivity Reactions to Acetylsicylic Acid. I. De-tection of Antibodies in Human Sera using AcetylsalicylicAcid attached to Proteins through the Carboxyl GroupAMos, H. E., WILSON, D. V., TAUSSIG, M. J., and CARL-TON, S. J. (1971) Clin. exp. Immunol., 8, 563 1 fig.,12 refs

Effects of Salicylates on the Gastric Mucosa as revealedby RoentgenE tion and the Gastrocamera EDMAR,D. (1971) Acta radiol. Diagn., 11, 57 3 figs, 18 refs

Effect of Aspirin Ingestion on Ascorbic-acid Levels inRheumatoid Arthritis SAHuD, M. A. and COHEN, R. J.(1971) Lancet, 1. 337 14 refs

Mode of Action of Aspirin. Effect of Dietary Aspirin onMitochondrial Pyruvate MetaboUsm in Normal and

iamine-Deficient Rats MEHLMAN et al. (1971) J. biol.Chem., 246, 1618

Aspiin: Effect on Thrombus Formation Time and Pro-thrombin Time of Human Subjects YOCHEM and ROACH(1971) Angiology, 22, 70

SurgeryEvaluation of Conservative and Surgical Treatment ofLumbar Disc Protrusion WEBER, H. (1970) J. Oslo CyHosp., 20, 81

To compare the results of surgical removal of the pro-lapsed lumbar disc with conservative treatment, theauthor interviewed 89 surgical and 101 non-surgicalpatients treated in the neurological and neuro-surgical

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Abstracts 557

departments of Ulleval Hospital, Norway, between 1960and 1964. Aged between 20 and 60 years, they had hadleg pain and neurological evidence of root compression.A prolapsed disc had been shown by myelography, inequal/numbers at L4/5 and L5/S1, and in ten patientsat L43 .

The lower roots showed no advantage for eithertreatment. Surgery was most effective in leptosome bodytypes and those with associated mental problems. Longperiods of incapacity made conservative treatment lesseffective. In all, surgery helped 95 per cent. of its groupand conservative measures 70 per cent. At follow-up,almost all the sensory changes had recovered, but 19 percent. of the surgical cases and 14 per cent. of the othershad pareses. Absent ankle reflexes returned in 33 percent. after surgery and in 48 per cent. after conservativetreatment. Failure of spinal fusion, attempted in all buteight cases, was not related to a bad result.

C. B. D'A. FEARN

Pathology of the Knee Joint in Rheumatoid Arthritis. AContribution to the Understanding of SynovectomyMILLS, K. (1970) J. Bone Jt Surg., 52-B, 746 12 figs,11 refs(Abstr. Wld Med. (1971), 45, 477)

Arthroscopy of the Knee Joint CASSCELLS, S. W. (1971)J. Bone Jt Surg., 53-A, 287 11 figs, 6 refs

Long-Term Results in Knee Arthrodesis in RheumatoidArthritis BRATTsTROM, H., and BRATTSTROM, M. (1971)Acta rheum. scand., 17, 86 2 figs

Tibial Osteotomy for Degenerative Arthritis of the KneeTORGERSON, W. R. (1971) Lahey Clin. Bull., 20, 773 figs, 12 refs

Tophectomy and Bone-Grafting for Extensive Tophi of theFeet BALASUBRAMANIAM, P., and SILVA, J. F. (1971)J. Bone Jt Surg., 53-A, 133 5 figs, 5 refs

Synovectomy of the Elbow for Rheumatoid ArthritisWILSON (1971) Proc. roy. Soc. Med., 64, 264

Synovectomy in Rheumatoid Disease (La synovectomiedans la maladie rhumatoide) POUGET, G., BENOIST, M.,DEBURGE, A., and CAUCHOIX, J. (1971) Presse med., 79,621 2 figs, 28 refs

Radioactive Osmic Acid Tracer in Synovectomy [InFrench] VERHAEGHE, A., CHECHAN, C., DELCAMBRE,B., HUART, M., THERY, J.-M., and LEONARDELLI, J.(1971) Rev. Rhum., 38, 247 (English summary p. 251)1 fig., 2 refs

Ulnar Deviation Splints COLLINS (1971) Hand, 3, 21

Dacron-Silicone Prosthesis for the Metacarpophalangealand Interphalangeal Joints NIEBAUER and LANDRY(1971) Hand, 3, 55

Surgical Treatment of the Rheumatoid Hand [In French]KENESI, C. (1971 Rev. Rhum., 38, 307 (English summary,p. 309) 15 refs

New Thoughts on Hand Prostheses COLLINS (1971)Hand, 3, 9

Artificial Finger Joints for Rheumatoid Arthritis CAL-NAN, J. S. (1971) Brit. J. Hosp. Med., 5, 487

Surgery in Rheumatoid Arthritis of the Hand BURNS, H.,and ZWEIG, J. (1971) N. Y. St. J. Med., 71, 340 6 refs

Other general subjectsEpidemic Polyarthritis in Eastern Australia, 1959-1970DOHERTY, R. L., BARRETT, E. J., GORMAN, B. M., andWHITEHEAD, R. H. (1971) Med. J. Aust., 1, 5 16 refs(Abstr. Wld Med. (1971), 45, 467)

Population Survey of Rheumatoid Arthritis. Epidemio-logical Aspects of the Syndrome, Its Pattern, and Effect onGainful Employment [Monograph in English] ALLAN-DER, E. (1970) Acta rheum. scand., Suppl. 15 40 figs,bibl.

New Haven Survey of Joint Diseases. XIII. Institutionaland Social Care for the Arthritic ACHESON, R. M.,CRAGO, A., and WEINERMAN, E. R. (1971) J. chron. Dis.,23, 843 1 fig., 23 refs

Relations between the Cervical Spine and the VertebralArteries CONSTANTIN, P., and LucRETLn, C. (1971)Acta radiol. Diagn., 11, 91 6 figs, 7 refs

Elements of the Biomechanics and Comparative Anatomyof the Shoulder (Elements de bio-mecanique et d'ana-tomie comparee de l'epaule) WELLINGER, CL. (1971)Rhumatologie, 23, 7 24 figs

Dysfunction of the Temporomandibular Joint in theGeriatric Patient GRIEDER, A., VrTON, P. W., andClNoTrI, W. R. (1971) J. Amer. Geriat. Soc., 19, 682 figs, 29 refs

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Arterlographic Investigations of the Normal Hip In AdultsMOSSBICHLER, H. (1971) Acta radiol. Diagn., 11, 19514 figs, 17 refs

Serious Ophthalmological Complicatios in the Ehlers-Danlos Syndrome BEIGHTON, P. (1970) Brit. J. Ophthal.,54, 263 3 figs, 19 refs

Ocular Changes in Auto-immune Diseases (Augen-veranderungen bei Autoimmunerkrankungen) WITMER,R. (1969) Ber. dtsch. ophthal. Ges., 70, 301 16 refs

Association of Perthes' Disease with Congenital Anomaliesof the Genitouinary Tract and Ingulal Hernia CArER-ALL, R. D. et al. (1971) Lancet, 1, 996

Stiff Man Syndrome [In French] SERRE, H., CADILHAC,J., SimON, L., MINVIELLE, J., and SANY, J. (1971) Rev.Rhum., 38, 253 (English summary, p. 262) 10 figs,bibl.

Morquio's Disease and Mucopolysaccharide ExcretionLINKER, A., EvANs, L. R., and LANGER, L. 0. (1970)J. Pediat., 77, 1039 2 figs, 38 refs(Abstr. Wld Med. (1971), 45, 398)

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abstracts - annals of the rheumatic diseases · ann. rheum. dis. (1971), 30, 545 abstracts...

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