Academic Centers Academic Centers Research Node of Research Node of

PECARNPECARN ((“ACORN”“ACORN”))

Supported by Project #U03 MC00001 from the Supported by Project #U03 MC00001 from the Maternal and Child Health Bureau, Health Maternal and Child Health Bureau, Health

Resources and Services Administration, Resources and Services Administration, Department of Health and Human Services Department of Health and Human Services

Who We AreWho We AreUniversity of California, Davis Medical Center,University of California, Davis Medical Center,University of California, Davis School of MedicineUniversity of California, Davis School of Medicine

Children’s Hospital of Wisconsin,Children’s Hospital of Wisconsin,Medical College of WisconsinMedical College of Wisconsin

Children’s Hospital of Philadelphia,Children’s Hospital of Philadelphia,University of Pennsylvania School of MedicineUniversity of Pennsylvania School of Medicine

St. Louis Children’s Hospital,St. Louis Children’s Hospital,Washington University School of MedicineWashington University School of Medicine

Primary Children’s Medical Center,Primary Children’s Medical Center,University of Utah School of MedicineUniversity of Utah School of Medicine

Children’s Hospital Medical Center,Children’s Hospital Medical Center,University of Cincinnati School of MedicineUniversity of Cincinnati School of Medicine

University of California, Davis Medical CenterUniversity of California, Davis Medical CenterUniversity of California, DavisUniversity of California, Davis

Nathan Kuppermann, MD, MPH Nathan Kuppermann, MD, MPH

Chair, Department of Emergency Chair, Department of Emergency Medicine,Medicine,

Professor of Emergency Professor of Emergency Medicine/PediatricsMedicine/Pediatrics

Emily Kim, MPHEmily Kim, MPH

ACORN Node AdministratorACORN Node Administrator

James Holmes Jr., MD, MPHJames Holmes Jr., MD, MPH

Professor of Emergency MedicineProfessor of Emergency Medicine

Leah Tzimenatos, MD

Assistant Clinical Professor

Department of Emergency Medicine/Pediatrics

Children’s Hospital of Children’s Hospital of Wisconsin, Wisconsin,

Medical College of WisconsinMedical College of Wisconsin

Marc Gorelick, MD, MSCEMarc Gorelick, MD, MSCEMedical Director, Emergency Department, Medical Director, Emergency Department,

Professor of Pediatrics and Emergency Professor of Pediatrics and Emergency Medicine Medicine

Children’s Hospital of Children’s Hospital of Philadelphia, University of Philadelphia, University of

PennsylvaniaPennsylvania

Elizabeth Alpern, MD, MSCEElizabeth Alpern, MD, MSCEAssistant Professor of PediatricsAssistant Professor of Pediatrics

Kathy Shaw, MD, MSCEKathy Shaw, MD, MSCEDivision Chief, Pediatric Emergency Division Chief, Pediatric Emergency

Medicine,Medicine,

Professor of PediatricsProfessor of Pediatrics

Evaline Alessandrini, MD, MSCEEvaline Alessandrini, MD, MSCEAssociate Professor of PediatricsAssociate Professor of Pediatrics

St. Louis Children’s Hospital, St. Louis Children’s Hospital, Washington University in St. Louis School of Washington University in St. Louis School of

MedicineMedicine

David Jaffe, MDDavid Jaffe, MDMedical Director of Emergency Medical Director of Emergency

Services,Services,

Professor of PediatricsProfessor of Pediatrics

American Family Children’s Hospital, American Family Children’s Hospital, University of Wisconsin School of Medicine & University of Wisconsin School of Medicine &

Public HealthPublic Health

Walton Schalick, MD, PhDWalton Schalick, MD, PhDEthics ConsultantEthics ConsultantAssistant Professor of Bioethics, Medical Assistant Professor of Bioethics, Medical

History, Pediatrics,History, Pediatrics,Orthopedics & Rehabilitation, History Orthopedics & Rehabilitation, History

of Science, of Science, and Historyand History

University of Wisconsin-MadisonUniversity of Wisconsin-Madison

Primary Children’s Medical Center, Primary Children’s Medical Center, University of UtahUniversity of Utah

Douglas Nelson, MDDouglas Nelson, MD

Professor of PediatricsProfessor of Pediatrics

Associate Chief, Pediatric Emergency Associate Chief, Pediatric Emergency MedicineMedicine

Cincinnati Children’s Cincinnati Children’s Hospital Medical Center, Hospital Medical Center, University of Cincinnati University of Cincinnati

College of MedicineCollege of Medicine

Richard Ruddy, MDRichard Ruddy, MDDirector, Division of Emergency MedicineDirector, Division of Emergency Medicine

Professor of Clinical PediatricsProfessor of Clinical Pediatrics

Where We Are Located Where We Are Located

ACORN Organizational ACORN Organizational Structure Structure

ACORN Proposal Generation ACORN Proposal Generation & Review Process& Review Process

ACORN Strengths

• ACORN investigators have high-level training and expertise in epidemiology/biostatistics/ethics

• ACORN members are senior-level PEM investigators with substantial research, grant writing and publication experience, and leadership in the field of PEM

• ACORN research proposals are subject to a rigorous internal review process with participation by all core ACORN investigators

ACORN-lead ResearchACORN-lead Research

Ongoing Projects:Ongoing Projects:• Randomized Trial of Oral Dexamethasone in Randomized Trial of Oral Dexamethasone in

Acute BronchiolitisAcute Bronchiolitis (subanalyses ongoing) (subanalyses ongoing)• PECARN Core Data Project PECARN Core Data Project • Head Injury ProjectHead Injury Project• Cervical Spine Injury ProjectCervical Spine Injury Project• Intra-abdominal Injury ProjectIntra-abdominal Injury Project• Patient Safety Project Patient Safety Project • Quality Measures ProjectQuality Measures Project

ACORN-lead ResearchACORN-lead ResearchFuture Research Endeavors:Future Research Endeavors:• Randomized Trial of IV Magnesium for Randomized Trial of IV Magnesium for

Treatment of Pain Crises in Sickle Cell DiseaseTreatment of Pain Crises in Sickle Cell Disease• Randomized Trial of C-Spine Immobilization in Randomized Trial of C-Spine Immobilization in

Children at Low-Risk for C-Spine InjuryChildren at Low-Risk for C-Spine Injury• Safety of Emergency Department Procedural Safety of Emergency Department Procedural

SedationSedation• Medical Error Reduction in Pediatric Emergency Medical Error Reduction in Pediatric Emergency

MedicineMedicine• RCT of Fluid Therapy for DKARCT of Fluid Therapy for DKA• Knowledge Translation Research of Information Knowledge Translation Research of Information

Generated by Completed PECARN Research Generated by Completed PECARN Research

Concluding StatementConcluding Statement

The ACORN Node of PECARN is committed The ACORN Node of PECARN is committed to applying our strengths and expertise to to applying our strengths and expertise to the study of the prevention and treatment the study of the prevention and treatment of acutely ill and injured children. of acutely ill and injured children.

We will maintain strong collaborations with We will maintain strong collaborations with all other Nodes of PECARN, the all other Nodes of PECARN, the MCHB/EMSC, and EMSC practitioners. MCHB/EMSC, and EMSC practitioners.

We are confident that the strong We are confident that the strong commitment of all the Nodes of PECARN commitment of all the Nodes of PECARN will insure the success of this robust and will insure the success of this robust and exciting network.exciting network.