academic program review self-study report 2017academic program review self-study report 2017...

ACADEMIC PROGRAM REVIEW SELF-STUDY REPORT

2017

Professional Program in Biotechnology Texas A&M University

Jack E. Brown Engineering Building College Station, TX 77843-3122

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Executive Summary This self-study report provides an overview of the interdisciplinary Professional Program in Biotechnology (PPiB) at Texas A&M University, and its progress toward fulfilling its core academic mission. This report focuses on activities since the previous academic program review in 2010, with the aim of identifying strengths and opportunities for future enhancement. The curriculum has been reorganized to provide more flexibility in selection of electives (increased from 3 to 9 credit hours) and business coursework (more flexibility in selection of the required 12 credit hours, as compared with the previous fixed course sequence). The content and organization of the professional portfolio reflection (a key part of each student’s final exam) has also been updated to focus on development of materials pertinent for a job interview. More broadly, we have engaged in a reflection of the need, importance, and outcomes of the program’s technical core courses. Professional development opportunities have continued to evolve and become enhanced, centered around an annual student development conference held in conjunction with our Industry Advisory Board. Field trips to local biotechnology companies, an annual student poster session and research conference, and a growing lecture series have also been implemented. The institutional model of financial support for interdisciplinary programs has also undergone a major evolution since 2010, with introduction of a formula based on enrollment, graduation rate, and faculty engagement. This model, combined with a program fee established in 2012, have provided stable sustained support for operational expenses. The number of students admitted to the program has remained relatively constant in the vicinity of 20 in each fall cohort. Academic metrics (test scores, GPA) have also remained relatively constant. Approximately 60% of the incoming students are female, with a majority being international. Since the 2010 program review, the PPiB has developed a sustainable, systematic, regular, and organized assessment, and continuous improvement process for its graduate program and curriculum to achieve its mission, objectives, and educational outcomes. The review of program outcomes occurs informally on a yearly basis as part of the yearly program assessment. Looking ahead, strengths of the program include a broad range of professional opportunities available at Texas A&M at the interface of science and business, sustained stable financial support, a growing local biotech industry and technology commercialization ecosystem, and institutional support of interdisciplinary education and research. Challenges include domestic student recruitment, keeping faculty engaged and matched with students having mutual interests, establishment of other “deep dive” courses to enhance student technical competencies, and expanded ability to provide student financial support.

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Table of Contents Executive Summary ....................................................................................................................................... i

1. Introduction ............................................................................................................................................1 1.1. Message from the Program Chair .................................................................................................1 1.2. Charge to the Peer Review Team .................................................................................................2

2. Institutional Overview ...........................................................................................................................3 2.1. Texas A&M University ................................................................................................................3 2.2. Dwight Look College of Engineering ..........................................................................................3 2.3. Graduate Interdisciplinary Programs ............................................................................................5

3. Professional Program in Biotechnology Structure .................................................................................6 3.1. Mission Statement ........................................................................................................................6

3.1.1. Program-level Mission Statement ............................................................................................6 3.1.2. University-level Mission Statement .........................................................................................6

3.2. Program Overview ..............................................................................................................................6 3.3. University-level Administration of the PPiB ......................................................................................7 3.4. Administrative Structure of the PPiB .................................................................................................9

3.4.1. Program Chair ..............................................................................................................................9 3.4.2. Program Coordinator ...................................................................................................................9 3.4.3. Executive Committee ...................................................................................................................9 3.4.4. Industry Advisory Council .........................................................................................................10

3.5. Institutional Allocations and Program Expenditures ........................................................................11 3.6. Overview of Progress Since Previous Academic Program Review ..................................................12

4. PPiB Curriculum and Student Experience ...........................................................................................13 4.1. Program Educational Objectives ................................................................................................13 4.2. Program Outcomes .....................................................................................................................13 4.3. Organization of Curriculum .......................................................................................................14 4.4. Rationale for Organization of the Current PPiB Curriculum .....................................................15 4.5. Overview of Required Coursework in the PPiB Curriculum .....................................................18 4.6. Directed Professional Internship ................................................................................................20 4.7. Professional Portfolio .................................................................................................................24

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4.7.1. Internship Preparation Documents .............................................................................................25 4.7.2. Reflection on Competencies ......................................................................................................25 4.7.3. Reflection on Internship .............................................................................................................26

4.8. Final Examination ......................................................................................................................27 4.9. Responsibilities of Committee Chair and Members ...................................................................27 4.10. Reflection on Need and Importance of PPiB Technical Core Coursework ...............................31 4.11. Reflection on the BIOT 685 Directed Studies Curriculum Component .....................................32 4.12. Reflection on BIOT 602 Biotechnology Principles and Techniques II ......................................33

5. Professional Development and Enrichment .........................................................................................34 5.1. Student Development Conferences ...................................................................................................34 5.2. Field Trips .........................................................................................................................................36 5.3. Directed Studies Poster Session/PPiB Annual Research Conference ...............................................37 5.4. PPiB Lecture Series ..........................................................................................................................39 5.5. Student Job Placement ......................................................................................................................40

6. Management and Sustained Support ....................................................................................................43 6.1. Financial Support ..............................................................................................................................43

6.1.1. Program Fee ...............................................................................................................................43 6.1.2. Institutional Allocation Formula for Interdisciplinary Programs ..............................................44

6.2. Program Coordinator ........................................................................................................................45 6.3. PPiB Faculty .....................................................................................................................................47

7. Recruitment and Admissions ...................................................................................................................52 7.1. Application and Admission Procedures ............................................................................................52 7.2. Student Demographics ......................................................................................................................53

8. Program Assessment ................................................................................................................................56 9. Strengths and Challenges .........................................................................................................................63

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1. Introduction

1.1. Message from the Program Chair The professional Program in Biotechnology (PPiB) welcomes you to Texas A&M University and thanks you for your service as external reviewers of our graduate professional program. We are pleased to have you assess our program and identify opportunities to continue to improve and enhance it. This self-study report was prepared for your review and reflects an evaluation of our professional program during the period since our last academic program review in 2010. It includes a brief history and background of the university, college, and program; and detailed information about our students, faculty, industry advisory council, and facilities. The report also provides a description of the program curriculum, admission process, academic enhancement opportunities, and key academic analytics such as degrees awarded as well as a brief analysis of the overall professional program. The academic program review offers an excellent opportunity for us to identify ways to maintain the current high standards of the program, and to learn from the vast experience of the review team bringing the perspective of similar programs and professionals in biotechnology field. Thus, we look forward to your feedback and await your recommendations on how we might improve our program as we continue to strive for excellence. We will be glad to answer any questions you might have and provide any additional information you might need. I look forward to meeting with you and during your visit on March 5 – 8, 2017. If you have any questions or require additional information, please do not hesitate to let me know. We realize this is a time-consuming task and thank you again for your service. Victor M. Ugaz, Ph.D. Professor Chair, TAMU Professional Program in Biotechnology Artie McFerrin Department of Chemical Engineering Holder of the Charles D. Holland’ 53 Professorship Holder of the Thaman Professorship

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1.2. Charge to the Peer Review Team Please use this report as a starting point to examine our program and make recommendations that will help guide improvements. Your resources are the self-study report prepared by the program, copies of materials from the program’s last review, information you gain through personal interactions while visiting Texas A&M University, copies of assessment plans and goal-setting documents at the program, college, and/or university level, and any additional information you may request. Within the broad charge of recommending how the program can continue to improve, some specific questions that we would like you to address are:

• Based on the data/information provided in the self-study report or gathered by the external review team, what are the program’s overall strengths and weaknesses?

• How well do the program’s strategic goals and priorities align with those of its college and with those of Texas A&M University?

• How would you compare this program with its peers?

• What improvements (including student learning and faculty development) has the program made since the previous program review?

• With only current resources or a modest infusion of new ones, what specific recommendations could improve the program’s performance, marginally or significantly?

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2. Institutional Overview

2.1. Texas A&M University Texas A&M University (TAMU), which attracted a mere six students when it opened in 1876 as Texas’ first public institution of higher learning, is now one of the top five largest institutions in the nation with a 60,435-member student body at the College Station campus including 14,943 graduate students (Fall 2016 data). Texas A&M University serves as a flagship of the Texas A&M University System. The A&M system is one of the largest systems of higher education in the nation, with a statewide network of 11 universities, a campus in Doha, Qatar, and seven state agencies including the Texas Engineering Experiment Station, the research arm of the Dwight Look College of Engineering. A&M System members educate more than 148,000 students and reach another 22 million people through service each year. With more than 26,000 faculty and staff, the A&M System has a physical presence in 250 of the state’s 254 counties and a programmatic presence in every one. System-wide, externally funded research expenditures exceeded $946 million to help drive the state’s economy. More than one in five students in a public university in Texas is enrolled in an A&M System institution. Texas A&M consistently ranks in the forefront among public universities in Texas in retention rates—keeping students enrolled and on course for graduation both overall and for African-American and Hispanic students. A&M System students receive about $580 million in scholarships and grants annually. The A&M System awarded 32,560 degrees in FY 2016.The A&M System’s faculty includes recipients of the Nobel Prize, National Medal of Science, Pulitzer Prize, World Food Prize and the Wolf Prize, as well as members in the National Academy of Sciences and the National Academy of Engineering. Texas A&M University consists of 16 colleges and schools, where teaching and research go hand in hand as it carries out its commitments as a land-, sea-, and space-grant institution—one of a select few universities to hold all three federal mandates. Its investment in research places it high in the rankings by the National Science Foundation and other federal agencies. The university’s research endeavors are complemented by a strong and growing graduate education program.

2.2. Dwight Look College of Engineering The Dwight Look College of Engineering ranks 2nd in the nation in research expenditures and Texas A&M also ranks in the top 10 in its endowment (over $5B). The Texas A&M College of Engineering is one of the largest engineering schools in the country, ranking second in undergraduate enrollment and fifth in graduate enrollment by the American Society for Engineering Education (ASEE) in its 2015 survey. The College of Engineering consistently ranks among the nation's top public undergraduate and graduate engineering programs, according to U.S. News & World Report.

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The Dwight Look College of Engineering on the College Station campus enrolled a total of 16,551 students, of which 21.4% (3,534) are pursuing graduate degrees. College of Engineering Dean, Dr. M. Katherine Banks, has created the 25 by 25 Initiative (25x25), which is planned to increase enrollment of engineering students to 25,000 by 2025 in order to provide increased access for qualified students to pursue engineering education. Beyond growth in the undergraduate programs, 25 by 25 targets a 15% growth in Master’s students and a 5% growth in Ph.D. students in the College. The Dwight Look College of Engineering at Texas A&M University includes fourteen departments – Aerospace Engineering, Biomedical Engineering, Biological and Agricultural Engineering, Chemical Engineering, Civil Engineering, Computer Science, Electrical and Computer Engineering, Engineering Technology and Industrial Distribution, Industrial and Systems Engineering, Materials Science and Engineering, Mechanical Engineering, Nuclear Engineering, Ocean Engineering and Petroleum Engineering. The College of Engineering is the largest college on the Texas A&M campus, and one of the largest in the country, with more than 15,000 engineering students enrolled. Texas A&M is ranked 14th nationally in the number of National Merit Scholars, and more than 50 percent of the university’s National Merit Scholars are engineering students. The college is ranked seventh in engineering graduate programs and eighth in undergraduate engineering programs among public institutions by U.S. News & World Report. The Dwight Look College of Engineering at Texas A&M has more than 500 faculty members, several of whom are National Academy of Engineering members, and fellows of their respective professional societies. They are also editors of their respective flagship journals and are recognized at national and international levels for their contributions. Since 2003, 73 faculty members have received the prestigious Faculty Early Career Development (CAREER) Award from the National Science Foundation. This award supports junior faculty by simulating the discovery process in which the excitement of research is enhanced by inspired teaching and enthusiastic learning. And since 2003, four junior faculty members have received the Presidential Early Career Awards for Scientists and Engineers (PECASE), the highest honor bestowed by the United States government on young professionals in the early stages of their independent research careers. College of Engineering researchers have established preeminence in the areas of energy, homeland and national security, engineering the ultra-small and space exploration. Underlying technologies that propelled the college to the forefront of the above research areas include mathematical modeling and simulation, optimization, mechanics, sensors, structures, robotics, autonomous vehicles, communications and networks, process engineering, materials, and computational sciences. Having established national and international reputations in these areas, TAMU researchers have expanded into the areas of sustainable advanced energy systems; national security; health care; infrastructure and transportation; and informatics and knowledge economy. The quality of TAMU research activities is highlighted by the direct impact of the research on technology; volume of peer reviewed research funding from highly competitive sources; volume of publications in high impact refereed journals; number of patents; volume of widely used textbooks; and national rankings of engineering programs.

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2.3. Graduate Interdisciplinary Programs At Texas A&M University, graduate degrees are awarded by traditional discipline-based academic departments, as well as by Graduate Interdisciplinary Faculties. Graduate Interdisciplinary Faculties are relatively new to Texas A&M with the earliest such faculty being officially recognized only in 1989. Their formation is primarily a faculty-driven process, when faculty members and researchers from diverse academic departments who have overlapping programmatic interests, come together to capitalize on their collective strengths. According to University rules, an Interdisciplinary Degree Program (IDP) involves a group of faculty from more than one discipline representing single or multiple colleges, organized for the purpose of enhancing research and scholarly activities and overseeing graduate education for a degree program not offered at any existing academic unit. These interdisciplinary faculties have to mature and document their abilities to administer a graduate program before they are authorized to award graduate degrees. The process for an interdisciplinary faculty to establish and administer a graduate degree program involves meeting specific university-level requirements and approvals at various levels within the university, prior to its approval at the state-level by the Texas Higher Education Coordinating Board. Oversight of IDPs falls under the responsibility of the Council of Participating Deans, which consists of the deans of the colleges having faculty participating in the IDP, together with the Dean of Faculties and Associate Provost and Provost for Graduate Studies. Faculty participation in an IDP may be incorporated into promotion, tenure, and merit raise decisions based upon recommendations of the IDP. In addition, graduate degrees granted by IDPs are also subject to external review as part of the University’s commitment to academic excellence. Presently, there are 11 Interdisciplinary Degree Programs at the University namely,

• Agribusiness (Master of Agribusiness) (MAB)

• Agribusiness and Managerial Economics (PhD)

• Biotechnology (Master of Biotechnology) (MBIOT)

• Ecology and Revolutionary Biology (PhD)

• Energy (MS)

• Genetics (MS & PhD)

• Marine Biology (MS &PhD)

• Molecular and Environmental Plant Sciences (MS & PhD)

• Neuroscience (MS & PhD)

• Toxicology (MS & PhD)

• Water Management and Hydrological Sciences (MS & PhD)

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3. Professional Program in Biotechnology Structure

3.1. Mission Statement 3.1.1. Program-level Mission Statement The mission of Professional Program in Biotechnology (PPiB) at Texas A&M is to educate and prepare students for national and international leadership roles in industry, business, academia and government; to attract top graduate students to professional science master’s degree in biotechnology; to develop new directions in biotechnology engineering education and curriculum; to be a valuable resource and service base to the State and the biotechnology profession; and to prepare students to solve problems of social and economic importance. 3.1.2. University-level Mission Statement Texas A&M University (TAMU) is dedicated to the discovery, development, communication, and application of knowledge in a wide range of academic and professional fields. Its mission of providing the highest quality undergraduate and graduate programs is inseparable from its mission of developing new understandings through research and creativity. It prepares students to assume roles in leadership, responsibility and service to society. Texas A&M assumes as its historic trust the maintenance of freedom of inquiry and an intellectual environment nurturing the human mind and spirit. It welcomes and seeks to serve persons of all racial, ethnic and geographic groups as it addresses the needs of an increasingly diverse population and a global economy. In the 21st century, Texas A&M University seeks to assume a place of preeminence among public universities while respecting its history and traditions. The program- and university-level mission statements are interwoven by a shared commitment to educate students, prepare them to assume leadership roles at the forefront of their professions, bringing innovation and creativity to education and training, and providing critically needed intellectual capital to address the workforce needs of the State and profession.

3.2. Program Overview The Professional Program in Biotechnology (PPiB) at Texas A&M University (TAMU) is a Professional Science Master’s program. It is a non-thesis degree program; however, students are required to complete a mandatory 10-week internship and a Professional Portfolio. The PPiB prepares science-trained professionals for careers in the rapidly-growing life science industries. These fields require professionals who possess a unique combination of knowledge and skill, not only of science, but also of business and communication. This mix of competencies is not readily available in most traditional life science degree programs. The PPiB at TAMU aims to fulfill this critical need for a specially-trained workforce. Students are also eligible to obtain a Certificate in Business or a Certificate in Entrepreneurship upon completion of their studies.

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The central premise behind establishment of the PPiB is to offer an attractive alternative for outstanding students who are not interested in the traditional research-oriented path through graduate school or professional school, but are more driven toward industry careers. This program was therefore created with the goal of opening doors to students who are interested in professional science careers with the potential to attain management positions within the companies where they work. The Texas Higher Education Coordinating Board approved the Professional Program in Biotechnology (PPiB) to offer the Master of Biotechnology (MBIOT) degree at Texas A&M University beginning with the class of 2001. To date, nearly 200 students have graduated from the program. The PPiB prepares graduates with an understanding of science, business, management, and communication through an interdisciplinary program of graduate classes and extracurricular experiences. The students enroll in classes offered across the University. Students gain practical experience through required laboratory courses, on-campus directed study opportunities, and a mandatory professional internship. The program is structured to provide formal and informal components to ensure that students think critically, solve problems creatively, work in teams cooperatively, and communicate and present effectively. This unique skillset, not readily available in traditional life science degree programs, enables graduates to hit the ground running as they embark on their careers, so that they quickly become indispensable assets to the workforce. By offering an interdisciplinary curriculum, the program is designed to establish a foundation that will allow graduates to advance rapidly in the industry. It also provides an additional post-baccalaureate option for TAMU students. The critical components of the program are:

• 39 credit hours of science and business courses

• Hands-on laboratory courses in biotechnology protocols

• Semester-long research experience in laboratory

• Ten week-long industry/professional internship

• Completion of a Professional Portfolio

• Active industry input via the PPiB Industry Advisory Council

3.3. University-level Administration of the PPiB Interdisciplinary degree programs (IDPs), unlike conventional department-based programs, are a hybrid and rely on host academic departments to provide administrative support staff, accounting, office space, and computer facilities (Figure 1). The level of support varies depending on the program and the department providing support. The current University

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administrative structure for managing IDPs, including the PPiB, requires that each IDP operates under a host Department and College/Unit, whose Dean reports to the Provost. The IDPs also report to the Dean of Faculties and Associate Provost for major policy issues. Since 2011, the PPiB has been hosted within the Artie McFerrin Department of Chemical Engineering in the Dwight Look College of Engineering. The Department of Chemical Engineering provides office space, administrative support, and business/accounting functions pertinent to daily operations.

Figure 1. Organizational structure of Interdisciplinary Degree Programs at Texas A&M University.

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3.4. Administrative Structure of the PPiB 3.4.1. Program Chair The PPiB is administered through a four-member elected Executive Committee and an elected Chair. The Chair of PPiB administers yearly academic reviews through the WEAVE online system, through the Program Coordinator administers program funds and approves spending, attends Graduate Instruction Committee meetings, represents the PPiB at Office of Graduate and Professional Studies (OGAPS) meetings, acts as the official advisor to graduate students, approves degree plans, and final exams. The chair crafts graduate admission offer letters, nominates students for graduate fellowships through the PPiB, and officially grants admission to students into the program that have been selected by the Admissions Committee. 3.4.2. Program Coordinator Dr. Larissa Pchenitchnaia was hired in November 2013 as a full-time Program Coordinator, whose duties span advising, program management, and accounting functions. General roles and responsibilities include with coordinating and overseeing the planning, development and implementation of all PPiB activities, providing professional-level administrative support to key faculty, research staff and administrative personnel. The Coordinator assists with implementing programs to facilitate program goals, assists in planning events, assists in preparing budgets for programs and events, responds to inquiries regarding program offerings, coordinates program communications and marketing, assists in proposal preparation and reporting, compiles program statistics, assists in updating training materials, assists in the maintenance of program records and databases, assists with evaluating current programs against program goals and objectives, identifies and recommends program improvements, and performs other duties as assigned. 3.4.3. Executive Committee The executive committee works with the Program Chair to determine and implement policy for the good of the Faculty of Biotechnology and represent the interests of the faculty generally to various University committees and other agencies. PPiB Executive Committee Membership

• Luc Bergman, College of Agriculture and Life Sciences

• Victoria Buenger, Mays Business School

• Wenshe Liu, College of Science

• Judith Ball, College of Veterinary Medicine and Biomedical Sciences, Member at Large

• Sakhila Banu, College of Veterinary Medicine and Biomedical Sciences, Member at Large

• Michael Criscitello, College of Veterinary Medicine and Biomedical Sciences

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3.4.4. Industry Advisory Council An Industry Advisory Council is actively involved in the Biotechnology program. Membership to the Advisory Council is by invitation. There is no financial commitment either by Advisory Council members, or by TAMU. Current membership of the Industry Advisory Council is listed in Table 1.

Table 1. PPiB Advisory Council Membership, 2016 – 2017.

NAME TITLE COMPANY Nathan Dewsbury Owner/GM Novis Animal Solutions, LLC,

College Station, TX Jerry Farrell, Ph.D. Chief Operating Officer FUJIFILM Diosynth

Biotechnology Texas, LLC College Station, TX

John Ferreira VP Quality Operations, Business Development

MDx BioAnalytical Laboratory, Inc. College Station, TX

Tyson Fetzer Senior Manager of Manufacturing

Sanofi Genzyme Boston, MA

Gary Krishnan, Ph.D. Chief Scientific Officer Eli Lilly & Company Indianapolis, IN

Susan Magdaleno, Ph.D. R&D Senior Manager, Scientist

Thermo Fisher Scientific Austin, TX

Sylvain Marcel, Ph.D. Senior Scientist iBio CMO LLC Bryan, TX

Madison Mauze VP Business Development Celltex Therapeutics Corporation Houston, TX

Deepthi Mikkili Manager, Clinical Data Management

Amgen Thousand Oaks, CA

Gunjot Rana Global Product Manager Luminex Corp. Austin, TX

Christie Sayes, Ph.D. Associate Professor of Environmental Science

Baylor University Waco, TX

Barbara Thomas Smith Owner Barbara Thomas Smith, LLC The Woodlands, TX

Cody L. Wilson, Ph.D. Senior Director, Food Safety Center of Excellence

The Coca-Cola Company Atlanta, GA

Ty K. Witten, Ph.D. Cotton, Soybean, Specialty Crop, and Seed Treatment Systems Lead

Monsanto Company St. Louis, MO

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3.5. Institutional Allocations and Program Expenditures The PPiB, like all interdisciplinary programs, receives funding directly from the Office of Graduate and Professional Studies (OGAPS). This funding model, adopted beginning in FY 2012, is based on the following formula that considers enrollment, graduation rate, and faculty engagement. Total IDP allocation = $15,000 base allocation [“chair support”]

+ $300*(# students) + $250*(# unique faculty advisory committee chairs/co-chairs) [“staff support”]

+ $12*(# weighted student credit hours) [“graduate enhancement”] + $240*(# master’s students enrolled) + $400*(# master’s students graduated) [“strategic support”]

The chair support category is intended to represent the base level of effort required to manage an interdisciplinary degree program. The staff support category represents the level of administrative effort scaled by enrollment and number of unique faculty members actively engaged in student advising. The graduate enhancement category reflects overall enrollment quantified by weighted credit hours. Finally, the strategic support category reflects the progress toward producing graduates from the program. Strategic supplements may also be allocated to IDPs depending on available funds during a particular fiscal year, which are typically used for targeted recruitment and student support. Beginning in FY 2012, a program fee of $530 per student per semester (fall and spring semesters only) was introduced as an additional line of sustained support for program operations (see Section 6.1 for additional discussion). An overview of program income and expenditures during the past 5 years is provided in Table 2. These data indicate that the PPiB has maintained a financially sound position, with resources to pursue strategic opportunities. For example, funds have been recently allocated for advisory council members to travel attend our student development conferences, to establish an annual student poster symposium, for a professionally facilitated etiquette dinner, and to achieve parity for instruction of BIOT 645 (Biotechnology Writing). Strategies for further allocations are described in Section 9.

Table 2. 5-year Summary of PPiB Program Income and Expenditures. FY 2012 FY 2013 FY 2014 FY 2015 FY 2016

Income

Base Allocation $68,452.00 $64,184.00 $67,496.00 $81,194.00 $84,637.00 Program Fee $29,150.00 $36,040.00 $36,570.00 $36,570.00 $35,510.00 Total $97,602.00 $100,224.00 $104,066.00 $117,764.00 $120,147.00

Expenditures

Salaries $60,536.30 $52,597.82 $90,470.60 $88,275.64 $90,803.95 Supplies $5,383.80 $6,334.71 $3,913.40 $5,838.28 $5,850.55 Total $65,920.10 $58,932.53 $94,384.00 $94,113.92 $96,654.50

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3.6. Overview of Progress Since Previous Academic Program Review An academic program review of the Professional Program in Biotechnology (PPiB) at Texas A&M took place on February 7 – 10, 2010. The review team was charged with examining the department and its programs and making recommendations to help in planning improvements. The team recognized the program’s value and contribution to the strategic missions of the University and biotechnology industry within the State of Texas. Sustained involvement of the Industry Advisory Council and the Office of Technology Commercialization were also noted as key strengths. Additionally, the review team provided recommendations to address challenges in three overarching areas: (1) curriculum and student experience, (2) management and sustained support of the program and (3) recruitment and admissions. These recommendations were aimed at enhancing the program’s stature and ensuring that the degree continues to represent a value and asset to students and stakeholders. The PPiB has continued to engage faculty and stakeholders to leverage the review team’s feedback and recommendations, ensuring continued responsiveness to the envisioned program outcomes and a broader faculty- and stakeholder-driven vision. Examples of key actions include the following. • Engagement of the Program Faculty to engage in frank discussions about our curriculum and

how it aligns with the Program’s broader vision.

• Engagement of the Program’s Industry Advisory Council to seek input about the curriculum and how it can be optimally structured to empower graduates with a superior skill-set that is responsive and sought after by the biotechnology industry.

• Overhauling the program’s continuous improvement plan to enable measurable assessment of program objectives, strengths, and weaknesses.

• Putting forward an institutional Program Fee request to provide a sustained line of funding for the Program Coordinator, an instrumental position solely focused on student support.

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4. PPiB Curriculum and Student Experience

4.1. Program Educational Objectives The PPiB educational objectives are consistent with the mission of the program, the needs of the program’s various constituencies (students, faculty, alumni, employers of graduates and co-op and intern students, advisory board members) and program outcomes.

1. Career Preparation. PPiB graduates will have foundation for breadth and depth across the range of advanced science, business and engineering topics for successful biotechnology careers in industry, business, academia and government.

2. Communication, Leadership, and Teamwork. PPiB graduates will be effective communicators and have appropriate leadership, project management and teamwork skills.

3. Integrity and Professional Impact. PPiB graduates will have a sense of responsibility and ethical conduct to their profession and an appreciation for the impact of their profession on society both nationally and internationally.

4.2. Program Outcomes The PPiB has documented student outcomes that prepare PPiB graduates to attain the program educational objectives. By the end of the program, PPiB students will have:

1. An ability to apply knowledge of advanced biological sciences and to use the scientific techniques and tools necessary for biotechnology practice

2. An ability to apply knowledge and skills of leadership, business and management in the biotechnology profession

3. An ability to analyze and interpret data

4. An ability to function on multidisciplinary teams

5. An ability to identify, formulate, and solve problems important in biotechnology practice

6. An understanding of professional and ethical responsibility

7. An ability to communicate effectively

8. An understanding of the impact of biotechnology practice in a scientific, economic and societal context

The inter-relationship between the program educational objectives and program outcomes is summarized in Table 3.

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Table 3. Relationship between PPiB Program Outcomes and Program Educational Objectives.

Program Outcomes

Program Educational Objectives

1. Career Preparation.

2. Communication, Leadership, and

Teamwork.

3. Integrity and Professional

Impact.

1. an ability to apply knowledge of advanced biological sciences and to use the scientific techniques and tools necessary for biotechnology practice

x

2. an ability to apply knowledge and skills of leadership, business and management in the biotechnology profession

x

3. an ability to analyze and interpret data x

4. an ability to function on multidisciplinary teams

x

5. an ability to identify, formulate, and solve problems important in biotechnology practice

x

6. an understanding of professional and ethical responsibility

x

7. an ability to communicate effectively x

8. an understanding of the impact of biotechnology practice in a scientific, economic and societal context

x

4.3. Organization of Curriculum A key challenge identified by the review team was that the curriculum lacked flexibility to accommodate students' special interests. The densely packed curriculum provides students with very little opportunity for electives barring them from pursuing special interests in biotechnology, whether on the science side or the business side. Prior to the 2010 program review, the 39 credit hours of the PPiB curriculum was organized to include a 3-part Biotechnology Principles and Techniques sequence (BIOT 601, 602; and 603; 4

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credit hours each) and 12 credit hours of rigidly specified business core courses (accounting, finance, marketing, and management). As shown in Table 4, this structure left only 3 credit hours available for students to choose electives based on their interests and professional goals. As shown in Table 5, the post-2011 PPiB curriculum has been updated by (1) removing BIOT 602, (2) replacing BIOT 603 with a 3-credit hour directed studies experience (BIOT 685), and (3) reducing the BOT 681 seminar requirement from two semesters to one semester. These modifications now provide 9 credit hours of student-selected elective coursework. Additionally, students now have flexibility to structure the required 12 credit hours of business coursework toward either core fundamentals (accounting, finance, marketing, and management), entrepreneurship, or a mixture of both. Further, although it is not a program requirement, students may arrange the business course sequence to satisfy the requirements to earn a Certificate in Business (http://mays.tamu.edu/certificate-in-business/) or Certificate in Entrepreneurship (http://mays.tamu.edu/center-for-new-ventures-and-entrepreneurship/graduate-certificate-in-entrepreneurship/ ) offered by the Mays Business School. An additional curriculum update made in response to the 2010 program review has been to embed a bioethics training requirement. Initially this was added through a dedicated 1 credit hour Bioethics Seminar course. This arrangement, however, was not ideal due to uncertainties associated with instructor availability that made it challenging to ensure that the required course could be offered on a regular basis. The program therefore adopted the Responsible Conduct of Research (RCR) training program offered through the Collaborative Institutional Training Initiative (CITI). The RCR series covers core norms, principles, regulations, and rules governing the practice of research. The National Institutes of Health (NIH), the National Science Foundation (NSF), and the U.S. Department of Agriculture (USDA) require certain categories of researchers to receive RCR training. RCR is increasingly viewed as an essential component of training, regardless of a researcher's source of funding. In addition to addressing the need to provide bioethics competencies, this training prepares students for hands-on laboratory work both on-campus (as part of the required directed studies experience) and in the workplace (as part of the required professional internship experience). The online delivery of the course content also ensures that it will be consistently available to students, who are required to complete the training during the first week of class during the semester when they enter the program.

4.4. Rationale for Organization of the Current PPiB Curriculum

The PPiB Curriculum is organized with the aim of establishing a solid foundation of technical and business skills, and providing opportunities for them to be applied in a professional context. This combination of fundamental and applied experiences is envisioned to set our apart from those graduating from research-focused degree programs. • Fall semester 1. Students enter as a common cohort and take coursework involving

fundamental molecular biology (BIOT 635) and applied laboratory techniques (BIOT 601). These courses provide a common set of core competencies to all students regardless of their undergraduate major. Students also obtain training in written and oral communications (BIOT 645), and begin guided career and professional explorations (BIOT 681).

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• Spring semester. Students begin required business coursework. Students also begin to apply fundamentals from the fall semester in an immersive practical context supporting their professional goals (BIOT 685).

• Summer semester. Students continue to apply fundamentals in a professional context via the required internship experience.

• Fall semester 2. Students complete remaining required and elective coursework. Students also complete final exam consisting of a written Professional Portfolio and oral presentation to the student’s committee members.

Table 4. Pre-2010 PPiB Curriculum.

Required Courses Course

Prefix Course Name Credit Hours Offered

BIOT 601 Biotechnology Principles and Techniques I 4 fall BIOT 635 Molecular Biotechnology 3 fall BIOT 645 Biotechnology Writing 3 fall BIOT 681 Biotechnology Seminar 1 fall BIOT 602 Biotechnology Principles and Techniques II 4 spring ACCT 640 Accounting Concepts and Procedures 3 spring BIOT 603 or BIOT 685 Applied Principles of Biotechnology 4 spring BIOT 684 Directed Professional Internship 4 summer FINC 635* Financial Management for Non-Business Majors 3 summer MGMT 655 Survey of Management 3 fall MKTG 621 Survey of Marketing 3 fall BIOT 681 Biotechnology Seminar 1 fall Electives

Electives Business, science or technology courses 3

program total 39

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Table 5. Post-2011 PPiB Curriculum.

Required Courses Course


BIOT 601 Biotechnology Principles and Techniques I 4 fall BIOT 635 Molecular Biotechnology 3 fall BIOT 645 Biotechnology Writing 3 fall BIOT 681 Biotechnology Seminar 1 fall BIOT 684 Directed Professional Internship 4 summer BIOT 685 Directed Studies 3 all N/A Online CITI Responsible Conduct of Research N/A fall 600 level Business courses* 12 Electives

Electives Business, science or technology courses 9

program total 39

*By selecting a particular set of business courses, students may earn one of

the following certificates through the Mays Business School

Certificate in Business Course


ACCT 640 Accounting Concepts and Procedures 3 all FINC 635* Financial Management for Non-Business Majors 3 all MGMT 655 Survey of Management 3 all MKTG 621 Survey of Marketing 3 all * ACCT 640 is pre-requisite for FINC 635

Certificate in Entrepreneurship (12 credit hours selected from the following) Course Prefix Course Name

Credit Hours Offered

MGMT 632 Technology Commercialization 3 all MGMT 637 Foundations of Entrepreneurship 3 all MGMT 638 Strategic Entrepreneurship 3 spring MGMT 639 Negotiations in Competitive Environments 3 all MGMT 640 Managing for Creativity and Innovation 3 fall FINC 644 Funding New Ventures 3 spring MGMT 658 Managing Projects 3 all MGMT 675 Leadership in Organizations 3 fall

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4.5. Overview of Required Coursework in the PPiB Curriculum Biotechnology Classes (see Appendix A for syllabi) BIOT 601. Biotechnology Principles and Techniques I. Credit 4. Basic theories and techniques essential to laboratory research in agricultural, environmental or medical biotechnology such as laboratory safety and records keeping, genome informatics, DNA analysis, RNA analysis, protein analysis and analysis of biological systems. Prerequisite: Graduate classification and approval of instructor. BIOT 635. Molecular Biotechnology. Credit 3. Theory and application of molecular biotechnology; consideration of the structure and function of cellular components and methods to characterize these components with reference to examples in industry. Prerequisite: Approval of instructor. BIOT 645. Biotechnology Writing. Credit 3. Development of biotechnology writing and editorial skills; communication of specialized information to the public and peers. Prerequisite: Graduate classification and approval of instructor. BIOT 681. Biotechnology Seminar. Credit 1. Review and discussion of current topics in biotechnology industries, with focus on skills essential to success in the corporate environment such as communication, interviewing and interpersonal skills. Prerequisite: Graduate classification and approval of instructor. BIOT 684. Directed Professional Internship. Credit 4. A directed internship in an organization to provide students with on-the-job training with professionals in organizational settings appropriate to the student’s professional objectives. Prerequisite: Approval of the Chair of the Faculty of Biotechnology. BIOT 685. Directed Studies. Credit 1 to 4. Training and experience in biotechnology; topics can include laboratory research, scientific literature reviews, biotechnology market surveys, and training in technology commercialization. Prerequisite: Approval of instructor. Accounting Classes ACCT 640. Accounting Concepts and Procedures I. Credit 3. Accounting concepts and relationships essential to administrative decisions; use of accounting statements and reports as policymaking and policy execution tools. Classification 6 students and non-business graduate students may enroll in this course. Prerequisite: Graduate classification. Finance Classes FINC 635. Financial Management for Non-Business Majors. Credit 3.

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External and internal factors affecting financial decision-making in the firm; fundamental concepts of accounting and managerial economics. Prerequisite: ACCT 640 or equivalent or approval of instructor. FINC 644. Funding New Ventures. Credit 3. This course provides an introduction to the general phenomena of small business and entrepreneurship. The central focus of this course will be to provide students an understanding of entrepreneurship and the financing of entrepreneurial ventures. The course will address the types of financing available at different stages of the new venture. Classification 6 students may not enroll in this course. Management Classes MGMT 655. Survey of Management. Credit 3. Management concepts and applications important to managers in all types and sizes of organizations; includes: strategic planning, goal setting, control and managerial ethics; decision making, organizing, human resource management, including staffing, performance appraisal and compensation; leadership, motivation, communication and group processes; achieving organizational quality and managing in a global environment. Prerequisite: Graduate classification. Note: This course may not be used for elective credit by a master’s candidate in business administration. MGMT 632. Technology Commercialization. Credit 3. Focus on technology, process of evaluating raw technology viability, converting raw technology into commercially viable products and services; course includes model on Small Business Innovation Research (SBIR) grant program; develops competencies skills to evaluate technology’s commercial viability; brings viable technologies to commercial success. Prerequisite: Graduate classification. MGMT 637. Foundations of Entrepreneurship. Credit 3. Process of launching a new venture; process by which opportunities can be discovered and selected; attributes of entrepreneurs and new venture teams; process of developing business plan; core entrepreneurial strategies—business level, organizational design, marketing, financial; strives to develop competencies, concepts, operational tools relevant to creating, implementing new ventures. Prerequisite: Graduate classification. MGMT 638. Strategic Entrepreneurship. Credit 1 to 3. Emphasis on a firm’s need to be both entrepreneurial (identifying opportunities in the market) and strategic (taking actions to gain a competitive advantage) in order to create value for stakeholders; includes: developing an entrepreneurial mindset; building an entrepreneurial culture; managing resources (building a resource portfolio, bundling resources to create capabilities and leveraging the capabilities to exploit the opportunities identified); creating innovations. Prerequisite: Graduate classification.

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MGMT 639. Negotiations in Competitive Environments. Credit 1 to 3. Understanding prescriptive and descriptive negotiation theory as it applies to dyadic and multi-party negotiations, to buyer-seller transactions, dispute resolution, development of negotiation strategy and management of integrative and distributive aspects of the negotiation process. Prerequisite: Graduate classification. MGMT 640. Managing for Creativity and Innovation. Credit 3. Examines factors that may foster or stifle individual, team, or organizational creative performance, and presents techniques that may improve the student’s creative thinking skills. Prerequisite: Graduate classification. MGMT 658. Managing Projects. Credit 3. Application of management processes to complex interdisciplinary organizational environments through the study of program and project management; adoptions of traditional management theories to the project environment; master typical project management microcomputer software for project planning; resource allocation; project budgeting; and control of project cost, schedule and performance. Prerequisite: Graduate classification. MGMT 675. Leadership in Organizations. Credit 1 to 3. Review of research on procedures, styles and methods of leadership, supervision, management and administration; all aspects of leader role behavior, both in practice and in research; areas in need of further research. May be repeated for up to 3 hours’ credit. Prerequisite: Graduate classification. Marketing Classes MKTG 621. Survey of Marketing. Credit 3. Marketing concepts and functions from the point of view of the organization and the economy. Prerequisite: Graduate classification. Note: This course may not be used for elective credit by a master’s candidate in business administration.

4.6. Directed Professional Internship BIOT 684 – Directed Professional Internship is a cornerstone of the PPiB curriculum because it immerses students in a professional setting so that they can learn from real-world work experiences. The objectives of the internship are two-fold. First, it enables students to apply their training to make identifiable contributions of practical concern to the organization offering the internship (i.e., solving a problem or creating a new product or knowledge of value to the biotech industry). Secondly, the internship allows students to function in a non-academic environment with a different culture and approach to management, public relations, and other endeavors. This ability to navigate the professional workplace empowers students with confidence as they begin the process of seeking full-time employment.

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The PPiB requires a minimum of 10 weeks of full-time employment (40 hours/week) for successful completion of the internship requirement. Internships cannot be for part-time positions, even if the number of weeks worked is extended beyond ten. The internship can be paid or unpaid. The preference is for students to obtain internship employment in the biotech industry; however, employment at other academic institutions or Texas A&M University affiliates, such as the Institute of Biosciences and Technology or the Office of Technology Commercialization, is acceptable. The internship is typically scheduled during the summer between the first and second years of study in the program (a list of recent internship sites is provided in Table 6). This timing allows students to take advantage of the fact that the majority of formal, dedicated internship programs of companies are offered during the summer. There are a limited number of internships and co-ops offered during the fall and spring semesters, and these can also be structured to satisfy the internship requirement. Note, however, that a student may not be employed at Texas A&M University as a teaching assistant and serve an internship during the same semester. Students may take extended co-op experience over two semesters, with the second semester of BIOT 684 counting as a program elective, or a student may take a second semester of an elective BIOT 684 at a different site. To be approved, the elective internship must be off-campus, under the supervision of the same faculty chair, and must not cause a delay in graduation beyond two academic years. Prior to the internship, whether required or elective, the student sets goals for the experience, which are formalized in the PPiB Learning Agreement along with a listing of responsibilities for all parties to the agreement. An additional degree requirement for the PPiB is the creation of a professional portfolio. This document contains a section in which students reflect on program competencies and a section dedicated to reflections on the internship experience. Upon completion of the portfolio, students give a public presentation on their internship experience followed by an oral exam by their faculty committee members. The committee members will ask further questions to assess mastery of science and business principles, and their application in the internship experience. Students doing two internships at different sites are required to reflect on both experiences in the portfolio and include both in the presentation given during the final exam. Before being allowed to register for BIOT 684, students are required to complete two documents and submit them to the program coordinator for review and approval: (1) the Internship Description Form, and (2) the PPiB Learning Agreement (copies provided in course syllabus in Appendix A). The Internship Description Form contains basic information about the internship including the job title, when and where the internship will take place, and contact information for the student, mentor and company. Students are also asked to submit a copy of their offer letter with the Internship Description Form. The PPiB Learning Agreement provides a listing of all the responsibilities of the various parties—the student, faculty advisor (committee chair), onsite supervisor, and program office—during the internship experience. It also frames the goals of the internship in terms of concrete “learning objectives.” These are written as broad objectives with specific activities or tasks that will accomplish the objective. They also document how the site supervisor will evaluate the student’s goals and deadlines for accomplishing the tasks. The Learning Agreement is signed by

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all parties (student, site supervisor, faculty advisor, and program coordinator) and returned to the program coordinator. Like the Internship Description Form, it must be received by the program office before students are allowed to register for BIOT 684. Half-way through, and at the conclusion of the internship, the site supervisor completes an evaluation of student performance. The intent of this evaluation is to provide the student with information that can be used to improve their work, and it also provides a basis for counseling and guidance of the student. The student and site supervisor both sign these evaluations and submit them to the program coordinator and to the student’s faculty advisor. Lastly, upon completion of the internship, students submit a Student Evaluation of Site. This feedback helps the program to ensure that only quality internship sites are offered to students. International students require additional procedures in order to arrange their internships. If the internship is during the summer, off-campus and paid, Curricular Practical Training (CPT) forms must be submitted to International Student Services (ISS) by F-1 students. J-1 (sponsored) students have similar requirements to obtain permission for off-campus employment. If an F-1 international student is completing an internship in the fall or spring, they must submit CPT forms and apply for a full course waiver, either from the Registrar’s Office or ISS, since they will be dropping below the required 9 credit hours of enrollment. The Program Coordinator assists students in navigating the requirements based upon the nature and timing of their internship plans.

Table 6. List of Recent Internship Locations and Companies.

Company/Site Location

Monsanto Woodland, California

Zoetis Durham, North Carolina

MD Anderson Cancer Research Center Houston, Texas

Caliber Biotherapeutics College Station, Texas

Pfizer Cambridge, Massachusetts

Synageva Biopharma Lexington, Massachusetts

Department of Veterinary Pathology TAMU, College Station, Texas

New England Biolabs Ipswich, Massachusetts

USDA, Insect Control and Cotton Disease Research Unit College Station, Texas

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Glycos Biotechnologies Houston, Texas

Kalon Biotherapeutics College Station, Texas

TAMU Health Science Center TAMU, College Station, Texas

Sigma-Aldrich St. Louis, Missouri

TAMU Health Science Center, Office of Technology Translation TAMU, College Station, Texas

InGeneron, Inc. Houston, Texas

National Center for Therapeutics Manufacturing College Station, Texas

Bio-Rad, Inc. Hercules, California

Department of Animal Science TAMU, College Station, Texas

Office of Technology Commercialization TAMU, College Station, Texas

K Global Fibers Bryan, Texas

Office of Safety and Security Office of Safety and Security, TAMU, College Station, Texas

SRC, Inc. North Syracuse, New York

New Orleans BioInnovation Center New Orleans, Louisiana

Novavax, Inc. Gaithersburg, Maryland

Applied Biosensors Salt Lake City, Utah

TAMU Health Science Center, Institute of Biosciences and Technologies Houston, Texas

Affymetrix Cleveland, Ohio

Gilead Sciences Foster City, California

Fort Worth Nature Center and Refuge Fort Worth, Texas

Center for Translational Research in Aging and Longevity TAMU, College Station, Texas

XYBION Bensalem, Pennsylvania

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ST Genetics Navasota, Texas

Luminex Corporation Austin, Texas

Bened Biomedical Co. Ltd. Taipei City, Taiwan

Medicenna Houston, Texas

DryLet Houston, Texas

Kleberg Animal and Food Science Center TAMU, College Station, Texas

Research Valley Partnership, Inc. College Station, Texas

Synthecon Houston, Texas

Ecolyse College Station, Texas

Agennix, Inc. Houston, Texas

Opexa Therapeutics The Woodlands, Texas

CS Bio Menlo Park, California

Thar Pharmaceuticals Pittsburgh, Pennsylvania

Aerosol Technology Laboratory TAMU, College Station, Texas

4.7. Professional Portfolio The purpose of the portfolio assignment is to collect in one place all the accomplishments of a student’s biotechnology career. Much of the portfolio consists of reflection on the skills and competencies students have obtained through coursework, informal learning experiences, and the internship. In response to the 2010 program review, the format of the portfolio was significantly revised to focus on development of materials important for a job interview. In addition to showcasing a student’s technical and professional accomplishments, the portfolio provides a resource for students to quickly recall specific occasions when they applied program competencies (e.g., solving an ethical problem or working productively as part of a team to solve a problem). The portfolio consists of a cover sheet, a table of contents, internship preparation documents, a section reflecting on biotechnology program professional competencies, another section reflecting on the internship experience itself, evaluations from the internship, and the PowerPoint presentation slides given at the final exam.

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4.7.1. Internship Preparation Documents 1. Resume. Students include a 2 – 3 page resume including educational background, honors or

recognition achieved, work experience, special skills, membership in organizations or other relevant information.

2. References. Students provide a list of names and contact information for 3-4 people that would be willing to provide a professional reference or recommendation. Examples would be a student’s faculty advisor or other faculty they interacted with, and former employers.

3. PPiB Learning Agreement. This is the document that lists the learning objectives for the student’s internship.

4.7.2. Reflection on Competencies In this section of the portfolio, students thoughtfully reflect on their experiences in the biotechnology graduate program. There are four core competencies that the PPiB curriculum is designed to develop in our students. These competencies are essential for success in business and other professional endeavors. Upon graduation, we expect that students should have acquired skills and abilities in the areas of (1) problem-solving, (2) teamwork, (3) communication, and (4) bioethics. For each of the four program competencies, students compose a 2 – 3 page essay explaining how they have acquired the competency during their time in the biotechnology program. Students may describe experiences from any class, and also draw from experiences associated with work and organizational/leadership activities at Texas A&M. For example, students could reflect on how they analyzed a problem in a biotechnology lab, solved an ethical problem encountered as a part of a directed studies experience, or how you organized and worked as a team on a Biotechnology Society project. In addition, you complete a 2 – 3 page essay on a fifth competency they acquired that they believe is a valuable skill in the marketplace. An example might be leadership or organizational skills. A description of each program competency is provided below. 1. Problem-solving ability. The ability to think through problems and devise solutions is an

important asset involving the following skills. • Critical thinking—the ability to clearly analyze a problem or situation and make a logical,

well-informed choice.

• Creative thinking—the ability to find innovative solutions to problems. • Consensus building—using techniques to enhance cooperation in a group.

• Personal judgment—understanding the role of values and emotions in decision-making. 2. Teamwork. The ability to work in a multidisciplinary team or group is critical in today’s

workplace. Examples of applying this competency include the following. • Collaborating on a project

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• Serving as a team leader • Managing conflict in a team

• Motivating a team • Delegating responsibility

3. Communication. Excellent written and oral communication skills are highly sought after by

employers. Examples of applying this competency include the following. • Effective speaking and listening

• Effective presentation of goals and ideas to an audience • Effective use of technology and media

• Effective writing of letters, memos, reports or position papers • Effective use of graphs, tables, or graphics to explain complex phenomena

4. Bioethics. This is a standard of conduct, or code of morals, for life science research. Students

are asked to reflect on occasions in their graduate study when they became aware of a controversial issue and its relationship to biotechnology. Students also may reflect more broadly on contemporary issues such as limitations to the use of technology.

4.7.3. Reflection on Internship This section of the portfolio begins with an introduction that describes the company or institution where the student worked, and what their responsibilities were during the internship. Next, students examine each of their learning objectives and the activities associated with each goal. In the course of this reflection, students describe the methods or procedures they used and the success or outcomes that followed, provide the results of experiments, describe protocols or other materials/deliverables produced, and discuss any limitations or failures encountered in the course of attaining their goals. If applicable, students also provide an analysis of accounting, finance, marketing, and management principles they used or observed at their internship site. Students are encouraged to connect concepts learned in classes with their internship experience, particularly highlighting occasions when they apply teamwork, analytical, and communication skills, or knowledge of bioethics. Students conclude by critiquing their experience, consider any additional learning that would be helpful, and provide recommendations for future students interning at their site. The reflective nature of the portfolio means that students primarily describe specific activities, the outcome of those activities, and what they personally learned. Students are also instructed to carefully document and cite sources for background information or other materials introduced into the document. Plagiarism is treated as a serious infraction of the Aggie Honor Code. If a student’s advisory committee detects plagiarism, depending on the situation, consequences can range from re-submission of the portfolio to failure to meet degree requirements for the MBIOT degree.

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In order to ensure confidentiality of data and business information, each student’s onsite is asked to supervisor review their PowerPoint presentation and contact the program office to communicate their approval and confirm that no material of a confidential nature is included. This verification is required before the final exam is allowed to commence.

4.8. Final Examination Students must submit a Request and Announcement of Final Examination form to the Texas A&M Office of Graduate and Professional Studies prior to the specified semester deadline. The request must be received 10 working days before the exam. Students are instructed to discuss deadlines for drafts of the portfolio with their faculty advisor to aid in scheduling sufficient time for thoughtful review and ultimately production of a high-quality portfolio and learning experience. The completed portfolio must be submitted in proper format to all committee members and the program coordinator one week prior to the final oral exam and portfolio presentation. Students are also encouraged to complete reflections on program competencies soon after completion of the activity, and that to submit them to your faculty advisor for review and feedback during the internship semester. Following the public presentation of the internship experience, the student meets in private with their committee where they are questioned further about their experiences and competencies associated with both science and business principles applicable to their work. The committee members may also ask students about coursework or competencies discussed in their portfolio and their relationship to the internship. When the committee is satisfied that they have sufficient information to make a decision, the committee deliberates and assigns a final pass/fail grade on the exam. If the committee feels that a student was unprepared or performed poorly, a second examination can be requested. No more than two attempts to pass the final examination are permitted.

4.9. Responsibilities of Committee Chair and Members Although the MBIOT degree is a non-thesis master’s degree, students must establish a 3-member faculty advisory committee consisting one chair and two members selected from the membership of the PPiB affiliated faculty. The advisory committee is formally established during the first semester in the program as part the degree plan that all students must submit to the Office of Graduate and Professional Studies, which also includes those courses to be applied toward the degree. The primary roles of the advisory committee chair and members are summarized below. Committee Chair (Table 7) • Meets with the student to discuss career plans, expectations for degree plan and portfolio,

possible electives for the degree plan, committee membership, possible faculty for BIOT 685 (Directed Studies), and suggestions for internship sites.

• Serves as resource for professional mentoring and advice.

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• Approves the degree plan, any petitions, and the request and announcement of final examination.

• Serves as BIOT 684 (Directed Professional Internship) instructor and approves the student’s internship Learning Agreement.

• Reviews and edits portfolio for content and language using the guidelines in the current Internship and Portfolio Handbook.

• Chairs the student’s presentation and oral exam, sets ground rules for the exam and tallies votes, and signs off on the final exam paperwork.

Committee Members (Table 8)

• Approve student’s degree plan (following pre-approval by program coordinator and committee chair) and any petitions for change in coursework or committee members.

• Serve as resource for professional mentoring and advice.

• Review portfolio in order to familiarize themselves with content prior to the student’s exam.

• Attend and participate in final exam.

Table 7. Recent Faculty Committee Chair Assignments (Fall 14, Fall 15 and Fall 16 Cohorts).

Committee Chair Department College

Dr. Rodolfo Aramayo

Department of Biology Science

Dr. Giri Athrey Poultry Science Agriculture and Life Sciences

Dr. Judith Ball Veterinary Physiology & Pharmacology

Veterinary Medicine and Biomedical Sciences

Dr. Sakhila Banu Veterinary Integrative Biosciences Veterinary Medicine and Biomedical Sciences

Dr. Luc Berghman Poultry Science Agriculture and Life Sciences

Dr. James Cai Veterinary Integrative Biosciences Veterinary Medicine and Biomedical Sciences

Dr. Robert Chapkin Nutrition and Food Sciences Agriculture and Life Sciences

Dr. Ernest Cothran Veterinary Integrative Biosciences Veterinary Medicine and Biomedical Sciences

Dr. Michael Criscitiello

Veterinary Pathobiology Veterinary Medicine and Biomedical Sciences

Dr. James Derr Veterinary Pathobiology Veterinary Medicine and Biomedical Sciences

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Dr. Robin Fuchs-Young

Molecular and Cellular Medicine & Institute of Biosciences and Technology

TAMU Health Science Center

Dr. Barbara Gastel Veterinary Integrative Biosciences


Dr. Terry Gentry Soil and Crop Sciences Agriculture and Life Sciences

Dr. Clare Gill Animal Science Agriculture and Life Sciences

Dr. Mark Holtzapple

Department of Chemical Engineering

Engineering

Dr. Charles Johnson Director, Center for Bioinformatics and Genomic Systems Engineering

Agriculture and Life Sciences

Dr. Katy Kao Chemical Engineering Engineering

Dr. Pushkar Lele Chemical Engineering Engineering

Dr. Wenshe Liu Chemistry Science

Dr. Carol Loopstra Ecosystem Science and Management


Dr. Clint Magill Plant Pathology & Microbiology Agriculture and Life Sciences

Dr. Rajesh Miranda Neuroscience & Experimental Therapeutics


Dr. Desmond Ng Agricultural Economics Agriculture and Life Sciences

Dr. Zivko Nikolov Biological and Agricultural Engineering

College of Engineering

Dr. Suresh Pillai Nutrition and Food Sciences Agriculture and Life Sciences

Dr. Michael Pishko Biomedical Engineering Engineering

Dr. James Sacchettini

Biochemistry and Biophysics Agriculture and Life Sciences

Dr. Stephen Safe Veterinary Physiology & Pharmacology


Dr. David Stelly Soil and Crop Sciences Agriculture and Life Sciences

Dr. Evelyn Tiffany-Castiglioni

Veterinary Integrative Biosciences Veterinary Medicine and Biomedical Sciences

Dr. Victor Ugaz Chemical Engineering Engineering

Dr. Jane Welsh Veterinary Integrative Biosciences Veterinary Medicine and Biomedical Sciences

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Dr. Mark Westhusin

Veterinary Physiology & Pharmacology


Dr. Karen Wooley Chemistry Science

Table 8. Recent Faculty Committee Members (Fall 14, Fall 15 and Fall 16 Cohorts).

Committee Chairs Department College

Dr. Robert Alaniz Microbial Pathogenesis and Immunology


Dr. Leonard Bierman Management Mays Business School

Dr. Wesley Bissett Veterinary Emergency Team Veterinary Medicine and Biomedical Sciences

Mr. Brett Cornwell Office of Technology Commercialization

Texas A&M University

Dr. Dana Gaddy Veterinary Integrative Biosciences Veterinary Medicine and Biomedical Sciences

Dr. Ivan Ivanov Veterinary Physiology & Pharmacology Veterinary Medicine and Biomedical Sciences

Dr. Spencer Johnston Entomology Agriculture and Life Sciences

Dr. Christopher Kerth Animal Science Agriculture and Life Sciences

Dr. Maria King Mechanical Engineering Engineering

Dr. Richard Lester Center for New Ventures and Entrepreneurship

Mays Business School

Dr. Mariappan Muthuchamy

Medical Physiology TAMU Health Science Center

Dr. Waithaka Mwangi Veterinary Physiology & Pharmacology Veterinary Medicine and Biomedical Sciences

Dr. Bhimanagouda Patil Vegetable and Fruit Improvement Center


Dr. Deborah Siegel Biology Science

Dr. Loren Skow Veterinary Integrative Biosciences Veterinary Medicine and Biomedical Sciences

Dr. Colin Young Veterinary Integrative Biosciences Veterinary Medicine and Biomedical Sciences

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4.10. Reflection on Need and Importance of PPiB Technical Core Coursework A key challenge identified in the 2010 academic program review involved re-affirmation of the importance of the technically-focused BIOT courses (BIOT 601 and 635), and the need for these to be taught through the program as opposed to directing students to existing courses in other departments. A fundamental motivation for incorporating these courses into the PPiB curriculum is to equip students with the hands-on knowledge of key processes performed in nearly every biotechnology laboratory so that they can engage in meaningful interactions with researchers in a corporate setting. The PPiB is aimed at delivering graduates trained to hit the ground running as they enter management positions in the biotechnology industry. But to be successful in a technologically driven field like this, it is critical for students to go beyond simply “knowing the lingo” but also fully appreciate the underlying science and its hands-on application. Feedback from the program faculty about this issue centered on the unique experience provided by BIOT 601 and 635, especially at the graduate level. The faculty expressed that this course goes beyond simply presenting standard lab procedures by challenging students to actually design experiments and controls. This advanced skill-set benefits the students even before they leave the program by preparing them to succeed in subsequent courses and giving them a distinct advantage in competing for on-campus positions involving biotechnology related research. Naturally, these benefits continue after graduation, where our students are increasingly sought after because they possess this kind of expertise. These sentiments are further echoed in the responses to our student satisfaction survey, where BIOT 601 was consistently identified as one of the program’s most impactful courses. Finally, the Industry Advisory Council also strongly affirmed support for this course, stating that it provides a unique breadth and depth to the hands-on experience. An illustrative example of someone working in the area of technical sales was posed, where the position involves marketing products directly to research scientists. The ability of the PPiB to train all BIOT students with a common set of laboratory skills provides the program the opportunity to benchmark the training and skills of our graduates. Without BIOT 601 and 635, it would be virtually impossible for graduates to communicate at a productive level, making them far less attractive to employers. Taken together, these strong expressions of support from three different channels (faculty, students, and industry) make a strong case for why this kind of course is needed in our curriculum. A professional program such as ours inherently centers on preparing students to become leaders in industry. Given this focus, how does a core laboratory course fit within this vision? A key issue expressed by both the program faculty and our Industry Advisory Council is the need to produce a consistent product. In other words, our past successes have led employers to expect a certain level of core competency in the scientific aspects of the biotechnology field. This unique skill set is central to our Program identity—the “brand name” we have worked hard to build for our students. BIOT 601 and 635 therefore serve as a signature foundational building block of our program because it gives employers confidence to know exactly what skill set they are getting when they hire PPiB graduates. Another question posed is whether there are other courses offered at Texas A&M that can provide a comparable educational experience to BIOT 601 and 635. We understand and appreciate the spirit of this question, and it led us as a faculty to think more deeply about this

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aspect of our curriculum. First, an overwhelming sentiment was expressed that these courses are unique, particularly at the graduate level. This impression is supported by the fact that we routinely receive requests from students in other departments seeking to enroll in them. This would not be the case if other such courses were readily available. Secondly, laboratory courses like BIOT 601 are somewhat unique in that they demand resources above and beyond those found in a typical classroom. Thus, they are subject to limits on section size and the frequency at which they are taught—limits that are beyond the control of our program. Given that the foundational skill set provided by this course is intended to be a signature of our program, it makes sense to guarantee that the course will be regularly offered and taught in a consistent way. The ability to teach a core course within our program also enables flexibility to continually refine the content so that we can ensure it is responsive to the needs of students and industry. A further sentiment expressed by our Industry Advisory Board focused on the teamwork aspect of BIOT-centered courses, whereby the students are able to progress as a unified cohort. This helps provide a nurturing environment to the incoming students that would not be possible if they were forced to take different courses scattered across multiple sections and/or different departments. This team building is especially important to establish as the students prepare to take on positions in industry. Finally, the question was raised regarding why students can’t be pre-screened, so that only students possessing these lab skills are admitted to the program. While we agree in spirit that more rigorous pre-screening can be useful, our faculty expressed concern that this model may be challenging to implement for assessment of hands-on competencies and research design. How would one pre-test students for these kinds of skills and define acceptable levels of mastery? More broadly, we strongly feel that a strength of our program is accessibility to students coming from a broad range of backgrounds, unified by a common interest in biotechnology. Building a foundation with a well-defined skill set ensures that everyone is on the same level, regardless of their past background. In other words, we prefer to embrace the idea of being as inclusive as possible in order to make this kind of training accessible to the broadest possible population of potential students, consistent with our broader institutional mission.

4.11. Reflection on the BIOT 685 Directed Studies Curriculum Component A final point regarding the curriculum raised during the 2010 program review involved taking steps to ensure that PPiB students engaged in the Directed Studies component of their practical training (BIOT 685) receiving an experience appropriate to a Professional Master’s student, as opposed to one closer to that of a research-focused MS student. In other words, the program should ensure that the student training is not focused on goals more closely aligned with academic research, as opposed to those of a professional degree. The matter was discussed at length by the program faculty, where it was suggested that the overall goals of a professional master’s program and their differences with MS oriented research be more clearly communicated to mentors in order to increase awareness and facilitate opportunities to include relevant elements into the experience. To accomplish this, we developed a project establishment form that is completed and signed by both the students and mentors before students are allowed to enroll in BIOT 685 (see course syllabus in Appendix A). This form ensures that expectations and the basis for grade assignments are clearly laid out from the outset. We also note the broad nature of BIOT

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685 experiences available, ranging from bench work in faculty research labs to technology evaluation and market analysis studies in the institutional commercialization office. We also updated the BIOT 685 course description to more closely communicate with the broader focus of a professional program.

4.12. Reflection on BIOT 602 Biotechnology Principles and Techniques II As part of the effort to introduce more flexibility for student-selected elective courses into the curriculum, in response to the 2010 program review, the laboratory-based Biotechnology Principles and Techniques course sequence was reduced to a single course (BIOT 601). In parallel with this transition, incoming PPiB students were admitted as a common cohort in the fall semester, during which students take all of the BIOT core courses. During the spring semesters of 2012 and 2013, an effort was made by the PPiB faculty to offer BIOT 602 as an elective course. A modular format was adopted involving 5 – 6 faculty members, each teaching a 2 – 3 week block. Topics included microfabrication and microfluidics, animal use in research, plant genomics, plant experimentation, and antibody techniques. The course was effective in enabling students to obtain deeper hands-on experience in each of the topic areas. However, challenges in offering the course included low enrollment (4 – 5 students) due to the difficulty in scheduling the substantial block of laboratory time required (1 – 5 PM, 2 days per week), and in availability of instructors to teach the modules on top of their existing departmental commitments.

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5. Professional Development and Enrichment A professional skills component involving an industry advisory board is a key cornerstone of the Professional Science Master’s degree. The PPiB has continued to leverage its advisory board to provide numerous opportunities for direct interactions beyond the classroom that further contribute to their professional training. These enrichment opportunities primarily include the following.

• Annual student development conferences

• Field trips to local biotechnology companies

• Directed studies poster session and research conference

• PPiB lecture series

5.1. Student Development Conferences Student development conferences are day-long on-campus events that bring first- and second-year students together with members of the PPiB Industry Advisory Board. The format and timing of these events has evolved based upon feedback from students and participants (Figure 2). Two primary formats have been employed. The first format follows a career exploration rotation schedule inspired by “speed dating” style events. Students are divided into groups of approximately 8 – 10 students who meet with panels composed of 3 – 4 industry representatives. The industry panels are divided into general areas aligned with the areas of expertise of the participating panelists (e.g., product development and R&D, regulatory affairs, technology transfer). The small group format enable students to have a closer interaction with the panel, as compared with the panel interacting with the entire group of students at once. Students in each group are asked to serve as moderators and collect questions to guide the discussions during the panel meetings. Approximately 45 minutes is allocated for each student group to meet with an industry panel, after which the groups rotate to the next panel. The cycle continues until all student groups have met with all panelists. These rotations typically occur in the morning, followed by a networking lunch. In the afternoon, senior students give short presentations about their internship experiences to the attendees, providing an opportunity for the students to showcase their work to the industry panel and receive feedback. These presentations also give incoming students an overview of the range of internship experiences that are possible as they begin their own search for positions the following summer. In recent years, we have added an award component whereby the presentations are scored by the industry participants and awards for outstanding presentations are given. Although we have tried several variations in the format of the student development conference (see agendas in Appendix B), the basic format described above has proven to be the most successful. One variation involves having the industry representatives give longer and more detailed presentations about their work, career path, and opportunities at their companies. This format was adopted in one of the conferences in response to student feedback, however the downside is that there is less opportunity for direct interactions between the students and the industry participants. Another format adopted was hosting the conference in Houston in an effort

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a.

b. c.

d.

Figure 2. (a) Student development conference formats held since 2011. (b) 2015 Student Development Conference and Advisory Council Meeting, Coca-Cola North America, Houston, TX. (c) 2016 Student Development Conference and Advisory Council Meeting, Memorial Student Center, Texas A&M University. (d) 2017 Student Development and Advisory Council Meeting, Memorial Student Center, Texas A&M University.

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to make the event more accessible to participants from that area and to include a field trip into the agenda. However, it was not clear that the students received significant added professional benefits, and the logistics and planning required significantly more effort. We are always open to trying new ways to engage students with the industry participants (e.g., including an “Etiquette Dinner” in this year’s agenda), but we generally find that allocating as much time as possible for students to interact directly with the industry participants is most effective.

5.2. Field Trips Several field trips are scheduled each year for students to tour local companies (generally in the Bryan/College Station or Houston areas) engaged in biotechnology related research. These visits give students an opportunity to gain a firsthand view of practices associated with the bio-technology profession, and connect fundamental concepts learned in the classroom with real-world applications. Some examples of field trips include visits to Celltex Therapeutics, Houston, TX; Lonza Inc., Houston, TX; iBio CMO, LLC, Bryan, TX; and FUJIFILM Diosynth Biotechnologies Texas, LLC, College Station, TX. a. b.

c.

Figure 3. Selected field trips to biotechnology companies. (a) Fall 2014 iBio CMO, LLC Bryan, TX. (b) Fall 2015 Celltex Therapeutics, Houston, TX. (c) Fall 2016 iBIO CMO, LLC, Bryan, TX

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5.3. Directed Studies Poster Session/PPiB Annual Research Conference A relatively new initiative we have adopted is a poster session held at the end of the Spring semester that gives first-year students an opportunity to showcase their accomplishments during the BIOT 685 Directed Studies component of the curriculum. This event also contributes to the communication skills competency, as each student is asked to give a brief oral summary of their poster to the entire group. Industry representatives are also engaged to judge the student posters and recommend awards for the most outstanding presentations. This event is now in its third year, and we are exploring a similar event in the Fall semester for students to present their internship activities. • 1st Annual BIOT Research Conference, May 6, 2015, Jack E Brown Engineering Building,

TAMU, College Station, Texas

List of titles/research topics/poster presentations

1. Chapman, M. Market Research: Phage based Pesticides and Stroke Therapy Perlecan Domain V. Supervisor Dr. C. Johnson

2. Cobb, C. Using Gas Chromatography/Mass Spectrometry/Olfactometry to Determine Aroma and Flavor Profiles of Food Products. Supervisor Dr. C. Kerth

3. Conrad, J. Technology Commercialization: SolarAgs Mobile Aps, supervisor Mr. Brett Cornwell

4. Reddy, P. Aberrant expression disrupts coordinated gene activation and repression in autistic brains. Supervisor Dr. James Cai

5. Rapp, J. Determining the structure and function of previously uncharacterized proteins in Mycobacterium tuberculosis (Mtb). Supervisor Dr. J. Sacchettini

6. Wood, E. Effects of gestational exposure to chromium VI on the fetal ovary development and reproductive function in the adult F1 rats, Supervisor Dr. Banu

7. More, S. Geographical Information System(GIS): SituMap: Technology Assessment. Supervisor Mr. Brett Cornwell

8. Rios, D. Risk Assessment of a BSL3 Laboratory Containment Breach. Supervisor Dr. Bissett

9. F. Pasaya. PCR Master Mix Economization. Supervisor Dr. Stelly

10. Ugamraj, H. Characterization of Metabolically Active yet Non-Culturable (MAyNC) Cells. Supervisor Dr. Pillai

11. Kumar, B. Surface Engineering of Lentiviral Vectors Using Split Inteins. Supervisor Dr. Z. Chen

12. Karki, K. NR4A1 as a Potential Drug Target for Acute Myeloid Leukemia. Supervisor Dr. S. Safe

13. Mueller, M. Nanoparticles and Bacterial Contamination in Nuclear Reactor Cooling Systems. Supervisors Dr. King and Dr. Hassan

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• 2nd Annual BIOT Research Conference, May 04, 2016, Jack E Brown Engineering

Building, TAMU, College Station, Texas

List of titles/research topics/poster presentations

1. Patil, K. Purification of African Swine Fever Virus antigen for Vaccine Development. Supervisor Dr. W. Mwangi

2. Sidhu, K. Control of Pierce’s Disease by Phage; Market Analysis for the Grape and Wine Industry. Supervisor Mr. Brett Cornwell

3. Bufford, J. AgConnect: Monetizing Free-to-Use Software. Supervisors Mr. B. Cornwell and Dr. T. Miranda

4. Balakavi, A. Innovation Research on identifying active NSF funded technologies at Texas A & M and mapping. Supervisor Dr. R. Lester.

5. Wellman, K. Evolution of Thermo-Tolerance in Saccharomyces cerevisiae and Resulting Cross-Tolerances. Supervisor Dr. K. Kao

6. Putta, M. & Patel, R. Production and downstream processing of r-collagen from E . Coli. Supervisor Dr. Nikolov

7. Bansal, I. Comparison of virulent and avirulent substrains of Theiler’s DA virus in the development of epilepsy in C57BL/6 mice. Supervisor Dr. Welsh

8. Sanghavi, S. Phage Cocktail Therapy for Xylella fastidiosa in Citrus & Olive Industry. Supervisor Mr. Brett Cornwell.

9. Wang, X. Three Dimensional TAMU Map: A Campus Collaborative Study. Supervisor Dr. M. King.

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10. Rohra, R. In Silico verification of miRNAs in the chicken genome. Supervisor Dr. G. Athrey.

11. Khasnavis, N. IGF-1 Promotes Mammary Stem Cell Self-renewal and Proliferation. Supervisor Dr. R. Fuchs-Young

• 3rd Annual BIOT Research Conference, scheduled for May 5, 2017, Jack E Brown

Engineering Building, TAMU College Station, Texas

5.4. PPiB Lecture Series In addition to the industry interaction opportunities available in the student development conference, field trips, and speakers in BIOT 681 Biotechnology Seminar, seminars involving external speakers from the biotechnology industry are scheduled. These events are typically scheduled during a lunch or late afternoon time frame so that there can be sufficient time for extended informal discussions and interactions between the students and the speaker.

• In October 2016, PPiB first guest speaker was Mr. Justin Liao from Thermo Fisher Scientific, Carlsbad, California. Mr. Justin Liao, is an application scientist working with Applied Biosystems; a part of Thermo Fisher Scientific. His major responsibility is to support and train end-users for Real-Time PCR detection and magnetic bead-based DNA and RNA extraction which can widely apply to molecular diagnostics for clinical, medical, pharmaceutical, environmental, foods safety and veterinary testing, etc. Mr. Justin Liao talked about theory of these technologies and its applications, especially in Animal Health diagnostic areas.

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• For March 2017, PPiB has scheduled a meeting with Mr. Tony Faucette, Senior Director,

Global Sterilization Services at Becton Dickinson, Franklin Lakes, New Jersey.

5.5. Student Job Placement A key strength of the program is student placement in permanent academic, industry or government positions. PPiB strives to promote and expand opportunities for its graduate students to engage in professional development activities that will prepare them for their future careers. These activities help graduate students develop professional skills to complement the discipline-specific knowledge they gain during the program, and begin to self-identify as professionals in the biotechnology industry. All PPiB professional development activities, internships, and research opportunities prepare PPiB graduates for a broad range of employment opportunities and help bridge the gap between graduate education and the workforce. An overview of the most recent job placement data (2014 – 2016 graduates) is provided in Table 9.

Table 9. PPiB Student Employment (Positions and Companies)

Title/Position Company/Place Process Development Associate Lonza, Houston, TX Validation Engineer Validation Associates, Herndon, VA Lab Technician InGeneron, Houston, TX Associate Manager-Scientific Affairs

Luminex Corporation, Austin, TX

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Associate Sales Consultant Kapa Biosystems, Houston, TX Product Specialist LI COR Biosciences, Lincoln, NE Project Manager Ajinomoto Althea, Inc., San Diego, CA Associate - Life Sciences Projects Cognizant, New York, NY Business Analyst Xellia Pharmaceuticals, Cleveland, OH Microbiologist Ecolyse, College Station, TX Quality Control Analyst II FUJIFILM Diosynth Biotechnologies, LLC, College

Station, TX Analyst Sedulo Group, Louisville, KY Commercialization Associate New Orleans BioInnovation Center, New Orleans, LA Program Analyst TAMU Health Science Center/Public Health Preparedness

and Response Department, College Station, TX Research Technician Department of Veterinary Pathobiology, TAMU, College

Station, TX Research Associate II Singulex, San Francisco, CA Downstream Manufacturing Tech II

FUJIFILM Diosynth Biotechnologies, LLC, College Station, TX

Lab Researcher III National Jewish Health, Denver, CO Research Assistant TAMU Health Science Center, College Station, TX Associate Scientist I, Vaccine Development

Paragon Bioservices, Inc., Baltimore, MD

Program Coordinator National Center for Therapeutics Manufacturing, College Station, TX

Lab Manager, Cardiovascular Medicine Laboratory Researcher II

Vanderbilt University Medical Center, Nashville, TN

PhD Student College of Veterinary Medicine and Biomedical Sciences, TAMU, College Station, TX

Associate Scientist (QC) DPT Laboratories, San Antonio, TX Clinical Research Associate DAVA Oncology, Dallas, TX Research Assistant Department of Medicine, Baylor College of Medicine,

Houston, TX Associate Scientist MD Anderson Cancer Center, Houston, TX Research Assistant Microbial and Pathogenesis and Immunology Lab, TAMU,

College Station, TX Doctor of Pharmacy Student University of Houston, Houston, TX Validation Analyst Validation Associates, LLC, Herndon, VA

PhD Student Agricultural Economics, College of Agriculture and Life

Sciences, TAMU, College Station, TX Clinical Monitoring Associate I PAREXEL, Raleigh-Durham, NC

Research Associate Microbial Pathogenesis & Immunology, TAMU Health

Science Center, TAMU, College Station, TX Biological Sciences Aide United States Department of Agriculture, USDA,

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Agricultural Research Service, College Station, TX PhD Student TAMU A&M Health Science Center, Institute for

Neuroscience Research Assistant Academy Biomedical, Houston, TX Project Coordinator Office of Technology Translation, Health Science Center,

TAMU, College Station, TX Project Manager PATH, Washington DC Agricultural Research Technician I TAMU Agrilife Research and Extension Center, Amarillo,

TX Toxicology Technician ESA Labs, The Woodlands, Texas Proposal Administrator II Texas A&M University System, College Station, TX Research and Development Associate

K-Global Fibers, Bryan, TX

Institute Associate Scientist MD Anderson Cancer Center, Houston, TX Analyst, Life Sciences PharmaBioSource, Inc., Philadelphia, PA Programmer/Analyst Baylor College of Medicine, Houston, TX Senior Market Analyst QuintilesIMS (Boston Biomedical Consultants), Boston,

MA PhD Student College of Vet Med and Biomedical Sciences, TAMU,

College Station, TX Cell Manufacturing Associate II Celltex Therapeutics Corporation, Houston, TX Licensing Specialist Rush University Medical Center, Chicago, IL Research Assistant I TeneoBio, Menlo Park, CA Analyst Zitter Health Insights, Livingston, NJ Software Development Intern Citrix, Miami, FL Science Teacher BISD, Bryan, TX Research Associate Celltex Therapeutics Corporation, Houston, TX Manufacturing Manager Celltex Therapeutics Corporation, Houston, TX Senior Research Associate Greenlight Biosciences Inc., Boston, MA Research Assistant/Lab Manager Baylor College of Medicine, Houston, TX Research Assistant II Vanderbilt University Medical Center, Nashville, TN Research Associate Integrated Metabolomics Analysis Core, College Station,

TX Project Manager USA SHADE & Fabric Structures, Dallas, TX Technology Commercialization Assistant

TAMU, College Station, TX

Project Manager RevaTis, College Station, TX Research Analyst DAVA Oncology, Dallas, TX Service Engineer SeqGen, Torrance, CA

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6. Management and Sustained Support The 2010 program review team pointed out challenges associated with maintaining consistent day to day operations of the program. These issues span domains involving staffing/personnel, and more broadly securing consistent and sustained financial resources. Numerous actions have been taken to address this feedback, collectively strengthening the program and positioning it for long-term sustainability and growth. Approximately one year prior to the 2010 program review, the PPiB had employed its first dedicated Program Coordinator. This position consisted of a part-time (80%, 4 days per week) appointment. The review team viewed this as a very positive change to the program, but cautioned that long-term year-to-year funding was needed to solidify the gains made by this position. Other recommendations included providing dedicated office space so that the Program Coordinator can communicate privately with recruits, students, and potential employers; and allowing time for the Coordinator to pursue big picture projects such as creating recruitment pipelines for domestic students and developing contacts for internships.

6.1. Financial Support At the time of the 2010 program review, the PPiB received a FY 2010 budget allocation of $45,778 ($40,778 from the College of Agriculture and Life Sciences and $5,000 from the College of Science), plus $9,500 in student support funds (Regents Fellowships) and $11,297 in instructional enhancement fees. This funding primarily supported a part-time program coordinator and instructor support for BIOT 601, 635, and 645. At the start of FY 2011, the program was informed that the College of Agriculture and Life Sciences would no longer be able to provide direct financial support to the PPiB. However, two actions during the same time mitigated any negative impacts from this change, and established a consistent model for sustained funding. 6.1.1. Program Fee The PPiB put forth a request for a program fee in the amount of $530 per student per semester (fall and spring, summer not included), which became effective during FY 2012. Revenue from this fee provides a new channel of sustained support for the Program Coordinator position. The Coordinator’s role is especially vital in the PPiB, where activities extend far beyond administrative and business functions associated with student advising. The Coordinator is responsible for a broad range of student support activities ranging from facilitation of corporate internships, recruitment of new industrial partners, recruitment of students from in-state institutions, and ensuring visibility of the program through involvement at relevant conferences—all of which greatly benefit students enrolled in the program. The program fee greatly enhances the PPiB’s ability to attract and retain top personnel in this critical position, particularly in the face of unexpected budgetary uncertainties. The proposed program fee was presented for student and public input in accordance with University and System regulations. In addition to the required referenda, a town hall meeting was called to gather feedback from all PPiB students who were currently enrolled in the program. As part of the vetting and approval process, an analysis of tuition rates associated with

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professionally-oriented biotechnology programs at peer institutions was performed (Table 10). This analysis indicates that the PPiB presents an outstanding value to students in terms of both in-state and out-of-state tuition. Table 10. Fall 2016 semester tuition at TAMU and peer institutions with biotechnology-oriented

professional science master's programs.

University PSMprogram Residenttuition Non-residenttuitionTexasA&M Biotechnology $5,018 $10,102UniversityofGeorgia Biomanufacturing&Bioprocessing $7,306 $17,045Illinois-Champaign-Urbana Bioenergy $7,850 $13,247GeorgiaTech Bioinformatics $7,953 $17,711PennState Biotechnology $9,982 $17,133Tuition data are for 12 credit hours, rounded to closest dollar, Fall 2016. TAMU data includes the $530 PPiB program fee. 6.1.2. Institutional Allocation Formula for Interdisciplinary Programs Beginning in FY 2011, a new institutional funding model was adopted whereby interdisciplinary programs received funding directly from the Office of Graduate and Professional Studies, as opposed to the previous system whereby funds were dispersed to participating colleges. This funding model adopted a formula based on enrollment, graduation rate, and faculty engagement. Allocations are determined via the formula below. Total IDP allocation = $15,000 base allocation [“chair support”]

+ $300*(# students) + $250*(# unique faculty advisory committee chairs/co-chairs) [“staff support”]

+ $12*(# weighted student credit hours) [“graduate enhancement”] + $240*(# master’s students enrolled) + $400*(# master’s students graduated) [“strategic support”]

The chair support category is intended to represent the base level of effort required to manage an interdisciplinary degree program. The staff support category represents the level of administrative effort scaled by enrollment and number of unique faculty members actively engaged in student advising. The graduate enhancement category reflects overall enrollment quantified by weighted credit hours. Finally, the strategic support category reflects the progress toward producing graduates from the program. Additional strategic supplements may also be allocated to IDPs depending on available funds, which are typically used for targeted recruitment and student support.

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6.2. Program Coordinator The sustained funding provided through the above-mentioned initiatives enabled the PPiB to hire a full-time program coordinator, Dr. Larissa Pchenitchnaia, an addition that has positively impacted students and stakeholders. Since joining the program in November 2013, Dr. Pchenitchnaia has built on the foundation laid by her predecessor, Ms. Marian Cothran, to engage in a diverse array of array of tasks normally delegated separately to accounting, advising, and program management staff. Many departments employ multiple full-time personnel to perform comparable ranges of tasks that the program coordinator is tasked accomplish as an individual. The coordinator must also interface with a wide range of program stakeholders including students, faculty, administration, alumni, and industrial advisory council partners. Examples of recent accomplishments include the following. • Ensuring placement of all students in internship positions. These efforts have helped to

shape the successful biotech careers of over 100 students since the previous program review. • Organizing student professional development conferences in a variety of settings and

formats. Notably, the November 2014 meeting took place at an industry site in Houston with representation from global executives of several leading companies in the field, the first time our program has had an offsite conference of this caliber.

• Ensuring that all first-year students have degree plans filed upon completion of their first

semester of coursework. • Interfacing with the admissions office and faculty Admissions Committee to facilitate review

of new student applications and communicating with prospective student applicants from admission to arrival at our new student orientation workshop.

• Taking initiative to completely redesign the program website, an effort that has proven

instrumental in bolstering recruitment of new students to the program. • Assisting the Biotechnology Society in planning field trips and extracurricular professional

development events. • Facilitating student placement in internship positions and locating new opportunities for

student employment. • Overseeing accounting and purchasing functions for the program, placing us in a secure

financial position. These roles and responsibilities have evolved and become greatly expanded since the 2010 program review. Consequently, the PPiB has initiated an effort to update the Coordinator position description so that it more accurately aligns with and reflects the broadened scope of activities. This analysis has led to the following updated list of roles and responsibilities.

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• Area 1: Programmatic Duties

1. Provide and coordinate advanced professional level administrative support to BIOT faculty and research staff of Biotechnology program (graduate committee assignments; plan and coordinate BIOT faculty meetings; etc.). Serve as an information resource on administrative operational methods and processes; Interact with the BIOT program Executive Committee; Interact with faculty and serve as a resource person to provide an exchange of information and to enhance the advisement of students.

2. Attend meetings or committees on behalf of the Biotechnology program. 3. Plan, develop, design, evaluate, and manage BIOT program to facilitate program mission,

educational objectives and outcomes; assist BIOT Chair in establishing program standards and objectives; plans work and assists BIOT Chair in determining program priorities; identify program improvements and recommend/implement solutions; analyze program statistics.

4. Coordinate event planning of BIOT research conferences, seminars, lectures, meetings and/or workshops for BIOT faculty and students; coordinate guest speakers and agendas for BIOT seminars etc.).

5. Prepares and monitors BIOT budgets for programs and events; fiscal reports; student scholarships; and business functions; develops project timelines.

Area 2: Interfacing with Stakeholders

1. Identify, recruit, and establish an internship program for the BIOT students with local, regional, state, national, and international biotechnology companies.

2. Identify and recruit biotechnology companies to be involved with the biotechnology program in student recruitment and placement; communicate with prospective employers of BIOT students regarding internships and full time job opportunities; Identify and recruit biotechnology companies to be involved in the Biotechnology program development such as curriculum enhancement, field trips, research conferences, student scholarships, etc.; organize plant field trips and supervise students during these field trips.

3. Work with the Chair of the Biotechnology Program in developing and strengthening the Biotechnology Program Advisory Council. Plan and coordinate Advisory Council meetings.

• Area 3: Interfacing with and Advising Students

1. Assist the Chair of the Biotechnology Program in developing an aggressive recruitment and retention plan. Recruit and advise graduate students concerning their educational or career goals, academic requirements, and related personal concerns.

2. Respond to inquiries regarding Biotechnology program offerings; serve as a primary information resource on Biotechnology program support methods and processes.

3. Handle admissions process for BIOT students: applicant pool; acceptance letters; coordinate admission process with TAMU Office of Admissions, International Student Services, OGAPS, etc. coordinate the maintenance of program records in TAMUDocs;

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coordinate work flow and promote communication between functional areas and outside units; provide information on and refers students to University resources that can assist them in meeting their needs or solving their problems.

4. Review and sign student forms; Approve degree plans, course substitutions, add/drops, Q drops, withdrawals, and change of curriculums. Verify completion of degree requirements.

5. Organize, coordinate and update new Biotechnology student orientation materials and training sessions.

6. Advise the BIOT students in the program and oversee students’ progress towards graduation.

7. Serve as the Advisor of the student-run Biotechnology Society. 8. Interact with the participating academic units in making sure BIOT students are able to

enroll in the required courses. 9. Provide academic advice to graduate students concerns, housing, financial aid, student

services, academic schedules, course schedules, course planning and selections, major options, and career and educational goals.

• Area 4: Marketing and Communications

1. Maintain materials for availability on the World Wide Web and coordinate such activities.

2. Coordinate the maintenance of office reference and resource materials.

3. Develop and supervise systems for maintaining records of student contacts. 4. Coordinate and design program communications and marketing materials.

5. Assist with other communication related items as assigned.

6.3. PPiB Faculty The Biotechnology Faculty has interdisciplinary expertise with its 72 members holding primary appointments in College of Agriculture & Life Sciences, College of Science, Dwight Look College of Engineering, Mays School of Business, the College of Veterinary Medicine & Biomedical Sciences, and the TAMU Health Science Center. The Biotechnology faculty has a good mix of senior experienced researchers, and full-time faculty members who represent different academic departments. A list of faculty is provided in Table 11. The faculty generally engage in the program by virtue of one or more of the following roles:

• Serving as Chair of PPiB graduate student advisory committees

• Serving on PPiB graduate student advisory committees and PPiB program committees

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• Teaching core PPiB courses (BIOT 601/BIOT 635/BIOT 645/BIOT 681)

• Supervising PPiB students in BIOT 685 Directed Studies

• Supervising PPiB students in BIOT 684 Directed Professional Internship

• Involvement in the Biotechnology Seminar series, recommending seminar speakers, or recommending Advisory Council members

• Providing PPiB programmatic input

• Assisting with PPiB student recruitment and job/internship placement All incoming students are encouraged by the Program Chair and Program Coordinator to review the list of BIOT faculty as soon as they are admitted to the program. When students arrive on campus, they meet and introduce themselves to program faculty members that they are interested to engage with. Additionally, PPiB faculty are invited to BIOT 681 Seminar class to meet and talk to students.

Table 11. List of PPiB Faculty with Primarily College/Unit and Departmental Affiliations

Name Department

College of Agriculture and Life Sciences

Athrey, Giridhar Poultry Science

Berghman, Luc Poultry Science

Chapkin, Robert S. Nutrition & Food Science

Coates, Craig Entomology

Defigueiredo, Paul Plant Pathology & Microbiology

Duong, Tri Poultry Science

Gentry, Terry Soil & Crop Sciences

Gill, Clare Animal Science

Ing, Nancy Animal Science

Islam-Faridi, Nurul Ecosystem Science & Management

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Johnson, Charles Genomics and Bioinformatics Service

Johnston, Spencer Entomology

Loopstra, Carol Ecosystem Science & Management

Magill, Clint Plant Pathology & Microbiology

Miller, J. Creighton Horticulture

Mullet, John Biochemistry & Biophysics

Ng, Desmond Agricultural Economics

Park, Bill Biochemistry & Biophysics

Pillai, Suresh Poultry Science

Rathore, Keerti Soil & Crop Sciences

Sacchettini, James Biochemistry & Biophysics

Stelly, David Soil & Crop Sciences

Wild, Jim Biochemistry & Biophysics

Young, Ryland Biochemistry & Biophysics

Yuan, Joshua Plant Pathology & Microbiology

Zhang, Hongbin Soil & Crop Sciences

Dwight Look College of Engineering

Cheng, Zhengdong Chemical Engineering

Grunlan, Melissa A. Biomedical Engineering

Han, Arum Electrical & Computer Engineering

Holtzapple, Mark Chemical Engineering

Jayaraman, Arul Chemical Engineering

Kao, Katy Chemical Engineering

King, Maria Mechanical Engineering

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Nikolov, Zivko Biological & Agricultural Engineering

Lele, Pushkar Chemical Engineering

Ugaz, Victor M. Chemical Engineering

Mays Business School

Buenger, Victoria Management

Lester, Richard Management

College of Science

Aramayo, Rodolfo Biology

Hilty, Christian Chemistry

Liu, Wenshe Chemistry

Patterson, C. O. Biology

Russell, David Chemistry

Siegele, Deborah Biology

Thomas, Terry Biology

Wooley, Karen Chemistry


Alaniz, Robert Microbial & Molecular Pathogenesis

Fuchs-Young, Robin Molecular and Cellular Medicine

Miranda, Rajesh Neuroscience & Experimental Therapeutics

Muthuchamy, Mariappan Systems Biology & Translational Medicine

Samuel, James Microbial & Molecular Pathogenesis

Cornwell, Brett Office of Technology Commercialization

College of Veterinary Medicine and Biomedical Sciences

Banu, Sakhila Veterinary Integrative Biosciences

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Ball, Judith Veterinary Pathobiology

Burghardt, Robert Veterinary Integrative Biosciences

Cai, James Veterinary Integrative Biosciences

Cothran, E. Gus Veterinary Integrative Biosciences

Criscitiello, Michael Veterinary Pathobiology

Derr, James Veterinary Pathobiology

Gastel, Barbara Veterinary Integrative Biosciences

Gresham, Vince Comparative Medicine Program

Ivanov, Ivan Veterinary Integrative Biosciences

Mwangi, Waithaka Veterinary Pathobiology

Safe, Steve Veterinary Physiology & Pharmacology

Skow, Loren Veterinary Integrative Biosciences

Tiffany-Castiglioni, Evelyn Veterinary Integrative Biosciences

Welsh, Jane Veterinary Integrative Biosciences

Westhusin, Mark Veterinary Physiology & Pharmacology

Young, Colin Veterinary Integrative Biosciences

Faculty Advising University rules and those of the PPiB govern the formation of student advisory committees and degree plans. Students in a master’s degree program must select a graduate chair, form an advisory committee, and file their degree plan by the end of the first semester. Prior to forming their committee, the PPiB Chair and Program Coordinator provide advising. A master’s degree advisory committee consists of no fewer than three members, the chair of which must be a full member of the PPiB faculty and two members who could both be PPiB faculty (or one external to the PPiB).

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7. Recruitment and Admissions

7.1. Application and Admission Procedures Since the 2010 program review, students have been admitted to the PPiB as a single cohort during the fall semester. Applicants to the Professional Program in Biotechnology (PPiB) apply online to Texas A&M University via the www.applytexas.org website. In addition to official and test scores (GRE (general test) and TOEFL (if applicable)), the application includes an essay detailing the applicant’s professional goals and motivation to pursue a biotechnology career, and three letters of recommendation. All materials are submitted directly to the Application Information System website. Once all materials are complete and received by Texas A&M University, students have access to the site to monitor the status of the application. Once the documents are entered into the electronic TAMUDocs system, the application materials are available to the PPiB for reviews. The Program Coordinator analyze the applicant credentials, organize the materials, and verify completeness before presenting the information to the faculty Admissions Committee. The Admissions Committee then reviews the applications and makes the admission recommendation to the Program Chair. The Chair and Coordinator then communicate with the applicants via email regarding the status of their application. From 2011 through 2014, the application deadline for fall admissions has been set at March 1 for all international and US students wish to be considered for scholarships. Beginning in 2015, delays at the Office of Admissions in calculating equivalent GPA information for international students made it necessary to delay the decision timeline until April 1 in order to allow time for this information to be made available. Once the admission recommendations are made, the Admissions Committee selects a subset of the applicants for merit-based scholarships consisting of a one-time $1,000 payment. The number of scholarships available has varied from 3 to 11, depending on the availability of program funds. These scholarships provide additional value by rendering the recipient eligible for the in-state tuition rate. Since the PPiB does not offer teaching or research assistantships, or fellowships, these merit-based scholarship awards constitute the primary mechanism to provide financial aid. PPiB Admissions Committee Membership

• Luc Bergman, College of Agriculture and Life Sciences

• Michael Criscitello, College of Veterinary Medicine and Biomedical Sciences

• Clint Magill, College of Agriculture and Life Sciences

• Rajesh Miranda, Texas A&M Health Science Center

• Victor Ugaz, College of Engineering

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7.2. Student Demographics Figure 4 shows application and enrollment trends since the 2010 program review. While the number of applications has fluctuated between 90 and 52, the number of students enrolled has remained relatively constant at approximately 20 per year. When combined with the students in their second year of study, there are approximately 30 – 35 total students enrolled in the PPiB during any given year.

Figure 4. Historical data for number of applications received, number of offers extended, number of acceptances, and number of students who matriculate to enroll in the Fall semester. Figures 5 and 6 shows data for the average GPA and test scores of the incoming class of students who enroll each fall. The GPA data fluctuate between approximately 3.4 and 3.6., with a recent upward trend observed in the 2016 class. A similar observation can be made with regard to the test scores, with relatively constant total GRE scores in the vicinity of 310 and TOEFL scores between 100 – 105. It should be noted that the TOEFL scores fall across a relatively broad range, with international students from India generally scoring higher than those from China and Taiwan. The average score is therefore influenced to some extent by the mix of country of origin. Figures 7 and 8 show the demographic profiles of the incoming class of students enrolling each fall. In terms of international vs. domestic classification, the majority of the enrollment has been international, with the exception of 2014. The recent trend has been toward an increasing fraction of international enrollment. In terms of gender, enrollment has fluctuated between majority female and majority male, with approximatively a 60/40 split on average.

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Figure 5. Historical GPA data for students matriculating in the fall semester of the indicated years.

Figure 6. Historical GRE (total, verbal, and quantitative) and TOEFL score data for students matriculating in the fall semester of the indicated years.

3.6 3.48 3.45 3.38 3.293.44

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Figure 7. Historical profile of domestic vs. international students matriculating in the fall semester of the indicated years.

Figure 8. Historical gender profile of students matriculating in the fall semester of the indicated years.

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8. Program Assessment Since the 2010 program review, the PPiB has developed a sustainable, systematic, regular, and organized assessment, and continuous improvement process for its graduate program and curriculum to achieve its mission, objectives, and educational outcomes. The review of program outcomes occurs informally on a yearly basis as part of the yearly program assessment. The purpose of continuous quality assessment and improvement system is to ensure that the program is achieving expectations as described by the objectives and outcomes and to evaluate how effectively our program has moved toward these goals. Assessment processes show faculty and administrators where improvements seem to be appropriate and guide the implementation of change within the program. Changes are monitored and re-evaluated to determine what improvement has been realized. Thus, the system is an ongoing evaluation of the effectiveness of the program. Tables 12 and 13 present summaries of assessment methods and assessment metrics used to assess program outcomes and objectives.

Table 12. Summary of PPiB Program Outcomes and Assessment Methods/Metrics.

Program Outcomes Assessment Methods and Assessment Metrics

1. An ability to apply knowledge of advanced biological sciences and to use the scientific techniques and tools necessary for biotechnology practice

Final Exam Evaluation Rubric (100% of students will be evaluated at “2” meets expectations and above on ability related to the question)

Co-op/Internship data/evaluations (100% of students will be evaluated at “2” meets expectations and above on ability related to the question)

2. An ability to apply knowledge and skills of leadership, business and management in the biotechnology profession



3. An ability to analyze and interpret data Final Exam Evaluation Rubric (100% of students will be evaluated at “2” meets expectations and above on ability related to the question)


4. An ability to function on multidisciplinary teams



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5. An ability to identify, formulate, and solve problems important in biotechnology practice



6. An understanding of professional and ethical responsibility



7. An ability to communicate effectively Final Exam Evaluation Rubric (100% of students will be evaluated at “2” meets expectations and above on ability related to the question)


8. An understanding of the impact of biotechnology practice in a scientific, economic and societal context



Table 13. Summary of PPiB Program Objectives and Assessment Methods/Metrics.

Program Objectives Assessment Methods and Assessment Metrics

1. Career Preparation. Post-Graduation Plans Survey/Data (job placement/graduate school placement majority students 70%)

Alumni Survey (Alumni indicate success in their careers, 3.5/5)

2. Communication, Leadership, and Teamwork.

Post-Graduation Plans Survey/Data (job placement or graduate school placement majority students 70%)

Alumni Survey (Alumni report they are effective communicators, leaders and engage in teamwork, 3.5/5)

3. Integrity and Professional Impact. Post-Graduation Plans Survey/Data (job placement or graduate school placement majority students 70%)

Alumni Survey (Alumni report they engage in professional activities that impact society, 3.5/5)

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The final exam is one of the most important criterion for program outcome assessment because it assesses most of the skills covered by the program outcomes at the time of graduation. At the end of each fall and spring semester, PPiB students present their portfolios to their graduate committee. The portfolios integrate material from required BIOT courses, as well as business and elective classes. Students make an oral presentation on their achievements throughout the program and internships and answer questions from the committee members. The examiners complete an evaluation form encompassing outcomes covering areas including presentation skills, technical skills, knowledge of advanced biological sciences, and teamwork (Table 14). These outcomes are mapped to the Program Outcomes. The results of these evaluations are compiled together to provide an overall assessment of student performance with respect to the program outcomes. Employers of co-op and internship students also complete Employer Evaluations of Co-op and Internship Student forms and submit these to Program Coordinator (Table 15). The questions on these evaluation forms are based on the PPiB program outcomes.

Table 14. PPiB Final Exam Evaluation Form

Professional Program in Biotechnology Final Exam Evaluation Form

Student Name_________________________________________________________________________________ Final Exam Committee Members __________________________________________________________________ Please use the following scale: “4” Outstanding, “3” Exceeds Expectations, “2” Meets Expectations, “1” Below Expectations Please check one box for each question for new graduates according to their ability to:

Student Skills Scale 4 3 2 1

1. apply knowledge of advanced biological sciences and to use the scientific techniques and tools necessary for biotechnology practice

2. apply knowledge and skills of leadership, business and management in the biotechnology profession

3. analyze and interpret data

4. function on multidisciplinary teams

5. identify, formulate, and solve problems important in biotechnology practice

6. have an understanding of professional and ethical responsibility

7. communicate effectively

8. have an understanding of the impact of biotechnology practice in a scientific, economic and societal context

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Table 15. PPiB Coop/Internship Supervisor Evaluation of Student Form

Professional Program in Biotechnology

Texas A&M University Final Site Supervisor Evaluation of Student Form

Student Name_________________________________________________________________________________ This is a formative evaluation because it is intended to provide information that a student can use to improve his/her work. The supervisor should evaluate and discuss the results with the student at the conclusion of the internship. Please use the following scale: “4” Outstanding, “3” Exceeds Expectations, “2” Meets Expectations, “1” Below Expectations PART I: Please check one box for each question for a BIOT student according to his/her ability/performance to:

Student Skills Scale 4 3 2 1

1. apply knowledge of advanced biological sciences and use the scientific techniques and tools necessary for biotechnology practice

2. apply knowledge and skills of leadership, business and management in the biotechnology profession

3. analyze and interpret data

4. function on multidisciplinary teams

5. identify, formulate, and solve problems important in biotechnology practice

6. have an understanding of professional and ethical responsibility

7. communicate effectively

8. have an understanding of the impact of biotechnology practice in a scientific, economic and societal context

PART II: Please comment on the following:

1. Student’s greatest strengths 2. Areas that need improvement 3. Describe any additional technical or business preparation prior to the internship that would have

improved student’s work performance 4. Give any other recommendations that would improve the internship program administration or

student experience 5. Please provide your contact information if you are interested in employing another Texas A&M

University Biotechnology student (e.g., email address)

Signatures: Site Supervisor: ________________________________________________________Date______________ Student Intern: _________________________________________________________Date_____________

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The primary goal of the PPiB is to produce graduates who have a strong foundation of skills and competencies developed through achievement of these program outcomes, which can then be built upon to achieve the broader program objectives. The curriculum is designed to accomplish this goal as a result of the collective experiences and knowledge obtained by completing all of the courses required for MBIOT degree. The program prepares an annual report that includes descriptions of the methods, assessment data, a report of the findings, and an action plan for sustained improvement. These data are maintained on an online database (WEAVE Online) that enables them to map to institutional assessment and reporting requirements. Annual assessment report tables for the 2015-2016 academic year are provided in Tables 16-18, with information on each outcome’s performance criteria, assessment metrics, and a summary of assessment results. A complete copy of the WEAVE Online program assessment report from the 2015 – 2016 cycle is provided in Appendix C.

Table 16. PPiB Program Outcomes Assessment for the 2015 – 2016 Academic Year.

Program Outcomes Academic year 2015-16 Final Exams Survey Results/Average Scores

1.an ability to apply knowledge of advanced biological sciences and to use the scientific techniques and tools necessary for biotechnology practice

Final Exam Evaluation Rubric (100% of students will be evaluated at “2” meets expectations and above on ability related to the question) Average Score 3.4 EXCEEDS Expectations



3. an ability to analyze and interpret data Final Exam Evaluation Rubric (100% of students will be evaluated at “2” meets expectations and above on ability related to the question) Average Score 3.3 EXCEEDS Expectations

4.an ability to function on multidisciplinary teams


5.an ability to identify, formulate, and solve problems important in biotechnology practice




7. an ability to communicate effectively Final Exam Evaluation Rubric (100% of students will be evaluated at “2” meets expectations and above on ability related to the question) Average Score 3.36 EXCEEDS Expectations

8.an understanding of the impact of biotechnology practice in a scientific, economic and societal context


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BIOT 684 Directed Professional Internship is a required class for all PPiB students. All nineteen students completed internships/co-ops during Summer 2015, Fall 2016 and Spring 2016. Site supervisors/employers completed Final Site Supervisor Evaluations. Table 17 provides summary of the results. Table 17. PPiB Internship Final Site Supervisor Evaluation Results for Summer 2015, Fall 2015

and Spring 2016.

Program Outcomes Final Site Supervisor Evaluations Survey Results/Average Scores

1.an ability to apply knowledge of advanced biological sciences and to use the scientific techniques and tools necessary for biotechnology practice

Final Site Supervisor Evaluation Rubric (100% of students will be evaluated at “2” meets expectations and above on ability related to the question) Average Score 3.8 EXCEEDS Expectations



3. an ability to analyze and interpret data Final Site Supervisor Evaluation Rubric (100% of students will be evaluated at “2” meets expectations and above on ability related to the question) Average Score 3.6 EXCEEDS Expectations

4.an ability to function on multidisciplinary teams


5.an ability to identify, formulate, and solve problems important in biotechnology practice




7. an ability to communicate effectively Final Site Supervisor Evaluation Rubric (100% of students will be evaluated at “2” meets expectations and above on ability related to the question) Average Score 3.6 EXCEEDS Expectations

8.an understanding of the impact of biotechnology practice in a scientific, economic and societal context


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Table 18. PPiB Program Objectives Assessment for the 2015 – 2016 Academic Year.

Program Objectives Assessment Methods and Assessment Metrics

1. Career Preparation. Post-Graduation Plans Survey/Data (job placement/graduate school placement majority students 70%) Both for Fall 2015 and Spring 2016 job placement was 100% (including 2 students admitted to graduate school)

2. Communication, Leadership, and Teamwork.

Post-Graduation Plans Survey/Data (job placement or graduate school placement majority students 70%) Both for Fall 2015 and Spring 2016 job placement was 100% (including 2 students admitted to graduate school)

3. Integrity and Professional Impact. Post-Graduation Plans Survey/Data (job placement or graduate school placement majority students 70%) Both for Fall 2015 and Spring 2016 job placement was 100% (including 2 students admitted to graduate school)

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9. Strengths and Challenges Since the 2010 program review, the PPiB has reaffirmed its focus on a curriculum that prepares students for a broad range of professional opportunities at the interface of science and business. Flexibility in the curriculum and diversity in the interdisciplinary faculty enables students to tailor their experience in the program to match their individual professional goals. As with any interdisciplinary program, the active and engaged faculty are also a key strength. The program has been further enhanced by achieving a stable sustained funding model that has, for example, allowed a full-time program chair to be hired and provided support for instructional faculty to teach the BIOT core courses (BIOT 601, 635, and 645). Student professional development has been further enhanced by a growing local biotech industry, providing new opportunities for field trips, internships, and permanent employment. In parallel, the technology commercialization ecosystem at Texas A&M has also continued to grow, providing numerous opportunities for students to become involved in technology commercialization. Finally, there has been a renewed commitment to support of interdisciplinary education and research at an institutional level, creating a fertile environment for programs like the PPiB to flourish. A key ongoing challenge remains recruitment of strong domestic students. This challenge dovetails with challenges in marketing the program and value of the Professional Science Master’s degree. We have engaged in various initiatives in an attempt to address this, including participation in graduate and professional school days locally and at other institutions (e.g., Sam Houston State University, University of Texas at Austin). But it is not clear that these events led to any increase in domestic applications. We have also updated the program website and social media presence, at one time even producing a blog (The PPiB Promoter), but the effort to produce new content was beyond the scope of the Program Coordinator’s already heavy workload. We are considering engaging students or interns in the communications area to assist in these efforts. It is also becoming clear that the scope of the program coordinator’s activities has broadened beyond the original position description, and should be revised to reflect the current scope of duties. Another challenge involves streamlining the process to match students and faculty chairs, given the broad and extended nature of Texas A&M. New events like the annual research symposium have succeeded in bringing faculty and students together, and a second annual symposium focused on internship experiences is planned. In terms of the curriculum, there is interest in establishing new “deep dive” courses to enhance student technical competencies. We attempted to address this by offering BIOT 602 in Spring 2012 and 2013, but found that it is challenging to identify extended blocks of class time when a majority of students can attend (their course choices diverge after the first semester based upon individual student interests) and to incentivize faculty to take on this additional teaching role above their commitments in their home departments. Finally, the program lacks funding to provide student financial support. Although the overall operating budget is sound, there are few funds specifically earmarked for student support. Our primary mechanism to provide financial aid has consisted of offering 3 – 11 merit-based scholarships (depending on available funds) consisting of a one-time $1,000 payment. Although these scholarships provide additional value by rendering the recipient eligible for the in-state tuition rate, we are generally not able to match offers from competing institutions.

ACADEMIC PROGRAM REVIEW SELF-STUDY REPORT

2017

List of Appendices

Appendix A Syllabi of PPiB Core Courses

Appendix B Student Development Conference Agendas

Appendix C WEAVE Online Report for the 2015 – 2016 Academic Assessment Cycle

Appendix D Faculty Meeting Minutes

Appendix E PPiB Bylaws

Appendix F Institutional Profile

Appendix G Faculty Curriculum Vitae

Appendix A

Syllabi of PPiB Core Courses

PROFESSIONAL PROGRAM IN BIOTECHNOLOGY BIOT 601 BIOTECHNOLOGY PRINCIPLES AND TECHNIQUES I Credits and contact hours: Credit 4.0; Lab 8.0 Instructor: Maria D. King

Text book:

1. M. R. Green and A. J. Sambrook. 2012. Molecular Cloning: a laboratory manual. 4th Edition. Volumes 1-3. Cold Spring Harbor Laboratory Press, New York. ISBN 978-1-936113-41-5 (cloth) – ISBN 978-1-936113-42-2 (pbk.)

2. Molecular Biology Techniques: A Classroom Laboratory Manual. 3rd Edition. H. Miller, D. S. Witherow, S. Carson. 2011. Academic Press. ISBN-13: 978-0123855442; ISBN-10: 0123855446

1. Specific course information

a. Description: Basic theories and techniques essential to laboratory research in agricultural, environmental or medical biotechnology such as laboratory safety and records keeping, genome informatics, DNA analysis, RNA analysis, protein analysis and analysis of biological systems.

b. Prerequisites: Graduate classification and approval of the instructor. c. BIOT 601 is a required course in the PPiB program

2. Specific goals for the course Upon completing this course, the students will be able to

1. Gain hands-on experience in basic molecular biology and microbiology laboratory principles and techniques that will be built on in BIOT 602 and applied by the students in their independent or directed research projects as part of BIOT 603 and BIOT 685.

2. Develop fundamental knowledge of laboratory principles and their application in biotechnology.

3. Become aware of safe laboratory practices and use basic lab equipment and tools. 4. Explain and practice methods used to clone and express genes from DNA to protein. 5. Gain confidence in their knowledge of theory and application of these basic laboratory skills

so that they can effectively apply them in future industry endeavors. 6. Demonstrate use of materials necessary for scientific experiments and demonstrate correct

scientific calculations. 7. Describe and document their experiments, results and conclusions following the standard

operating procedures for keeping a laboratory notebook. 8. Recognize when additional assistance is warranted, troubleshoot experiments that do not

work. 9. Create thought-provoking questions related to the laboratory material; and synthesize a

strategy for cloning a gene of interest and expressing and purifying the protein.

3. List of topics to be covered Topics

Introduction, Expectations, Basic laboratory skills and assays

Bacterial growth curve; DNA extraction

Anaerobic culturing techniques; Polymerase Chain Reaction (PCR)

Agarose gel of PCR products, introduction to PubMed database

Purification of PCR product, Restriction digest

Separation of PCR product in agarose gel; gel purification

TOPO TA vector cloning, Transformation of E. coli competent cells

Transformation efficiency, DNA Miniprep, PCR to verify cloning

Restriction digest, Agarose gel and gel purification

BigDye PCR for sequencing Sephadex-50 column cleanup, sequencing Restriction digest of vector, dephosphorylation, gel purification Ligation of insert into vector, transformation of competent cells Evaluate sequences (Chromas, NCBI website), Colony PCR to verify insert Visit Borlaug (30 min talk), Select colonies with insert/vector to culture o/n

Streak colonies with insert, Plasmid extraction, Transform expression host Start cultures (7am), induction (10am) to express cloned protein, Extract protein (Bugbuster), BioRad Bradford assay for protein content, SDS-PAGE

Immunoaffinity purification of expressed protein (His-Tag Ni-NTA columns) Separate crude protein lysate and purified protein fractions by SDS-PAGE, Blot & stain gel Evaluate SDS PAGE, Proceed with Western Blot using MAb Kirby Bauer diffusion susceptibility test with nanoparticles and antibiotics

Soil phage isolation, Bacteriophage T7 plating and quantification RNA extraction, Reverse Transcription PCR Verification of the reverse transcription products Helium plasma treatment for surface and aerosol decontamination Evaluation of plasma treatment plates; Lecture (Convective PCR) Lecture (Bioinformatics: Illumina sequencing)

BIOT 601 Student Learning Outcomes and PPIB Student Outcomes

BIOT 601 Student Learning Outcomes PPIB Student Outcomes 1. Gain hands-on experience in basic molecular

biology and microbiology laboratory principles and techniques that will be built on in BIOT 602 and applied by the students in their independent or directed research projects as part of BIOT 603 and BIOT 685.

PPIB Outcome 1 An ability to apply knowledge of advanced biological sciences and to use the scientific techniques and tools necessary for biotechnology practice.

2. Develop fundamental knowledge of laboratory principles and their application in biotechnology.

PPIB Outcome 2 An ability to apply knowledge and skills of leadership, business and management in the biotechnology profession.

3. Become aware of safe laboratory practices and use basic lab equipment and tools.

PPIB Outcome 4 An ability to function on multidisciplinary teams.

4. Explain and practice methods used to clone and express genes from DNA to protein.

PPIB Outcome 6 An understanding of professional and ethical responsibility.

5. Gain confidence in their knowledge of theory and application of these basic laboratory skills so that they can effectively apply them in future industry endeavors.


6. Demonstrate use of materials necessary for scientific experiments and demonstrate correct scientific calculations.

PPIB Outcome 5 An ability to identify, formulate, and solve problems important in biotechnology practice.

7. Describe and document their experiments, results and conclusions following the standard operating procedures for keeping a laboratory notebook.

PPIB Outcome 3 An ability to analyze and interpret data.

8. Recognize when additional assistance is warranted, troubleshoot experiments that do not work.

PPIB Outcome 7 An ability to communicate effectively.

9. Create thought-provoking questions related to the laboratory material; and synthesize a strategy for cloning a gene of interest and expressing and purifying the protein.

PPIB Outcome 8 An understanding of the impact of biotechnology practice in a scientific, economic and societal context.

PROFESSIONAL PROGRAM IN BIOTECHNOLOGY BIOT 635 MOLECULAR BIOTECHNOLOGY Credits and contact hours: Credit 3.0; Theory 3.0; Lab 0.0 Instructor: Maria D. King Text book: M. Wink (2013) An Introduction to Molecular Biotechnology. John Wiley & Sons, New York. ISBN: 978-3-527-32637-2. Additional course notes and original journal articles will be provided.

1. Specific course information

a. Description: Theory and application of molecular biotechnology; consideration of the structure and function of cellular components and methods to characterize these components with reference to examples in industry.

b. Prerequisites: Graduate classification and approval of the instructor. c. BIOT 635 is a required course in the PPiB program

2. Specific goals for the course

Upon completing this course, the students will be able to

1. Develop fundamental knowledge to explain the major components, processes and mechanisms of cellular and molecular biology and genetics.

2. Examine, discuss and judge the impact of gene modification on agricultural, environmental, and medical sciences.

3. Develop the theoretical background necessary to choose and apply appropriate methods and techniques used in contemporary biotechnology at the cellular and molecular levels.

4. Interrelate principles from cellular and molecular areas to biotechnology.

5. Propose and use appropriate chemical-physical principles and their correct applications.

6. Apply appropriate computer software for statistical analyses, database mining, and data presentation.

7. Research, design and present a scientific case study; select and apply reference sources.

8. Cite appropriate regulations associated with biotechnology industry and laboratories.

9. Learn the concepts associated with molecular biotechnology as a foundation for other classes in the Professional Program in Biotechnology, directed studies or independent research.

2. List of topics to be covered Topics

Fundamentals of Molecular Biotechnology Cell as the basic unit of life Structure and Function of Cellular Macromolecules – Sugars

Structure and Function of Cellular Macromolecules - Lipids

Structure and Function of Cellular Macromolecules - Proteins

Structure and Function of Cellular Macromolecules – Nucleic acids

Structure and Function of a Cell

Membranes

Membrane Transport

Biosynthesis and Function of Macromolecules (DNA, RNA and Proteins) Replication Biosynthesis and Function of Macromolecules Transcription Biosynthesis and Function of Macromolecules Translation Distributing Proteins in the Cell (Protein Sorting)

Molecular Basis of Evolution

Standard methods in Molecular Biotechnology Isolation and Purification of Proteins Isolation of DNA and RNA

Chromatography and Electrophoresis of Nucleic Acids

Hybridization of Nucleic Acids

The Use of Enzymes in the Modification of Nucleic Acids Polymerase Chain Reaction (PCR) DNA Sequencing Cloning Procedures Promoters Expression of Recombinant Proteins Genomics Functional Genomics Protein-Protein Interactions (PPI) Protein-DNA Interactions (PDI) Applications of Molecular Biotechnology Molecular Diagnostics in Medicine Recombinant Antibodies and Phage Display Genetically Modified Mice Gene Therapy Plant Biotechnology Phage Therapy and Antibiotic Resistance

BIOT 635 Student Learning Outcomes and PPIB Student Outcomes BIOT 635 Student Learning Outcomes PPIB Student Outcomes 1. Develop fundamental knowledge to

explain the major components, processes and mechanisms of cellular and molecular biology and genetics.


2. Develop the theoretical background necessary to choose and apply appropriate methods and techniques used in contemporary biotechnology at the cellular and molecular levels.

PPIB Outcome 2 An ability to apply knowledge and skills of leadership, business and management in the biotechnology profession.

3. Interrelate principles from cellular and molecular areas to biotechnology.

PPIB Outcome 4 An ability to function on multidisciplinary teams.

4. Propose and use appropriate chemical-physical principles and their correct applications.


5. Apply appropriate computer software for statistical analyses, database mining, and data presentation.

PPIB Outcome 3 An ability to analyze and interpret data.

6. Examine, discuss and judge the impact of gene modification on agricultural, environmental, and medical sciences.

PPIB Outcome 6 An understanding of professional and ethical responsibility.

7. Research, design and present a scientific case study; select and apply reference sources.

PPIB Outcome 7 An ability to communicate effectively.

8. Cite appropriate regulations associated with biotechnology industry and laboratories.

PPIB Outcome 8 An understanding of the impact of biotechnology practice in a scientific, economic and societal context.

9. Learn the concepts associated with molecular biotechnology as a foundation for other classes in the Professional Program in Biotechnology, directed studies or independent research.


PROFESSIONAL PROGRAM IN BIOTECHNOLOGY

BIOT 645 BIOTECHNOLOGY WRITING

Credits and contact hours: Credit 3.0

Instructor: Colin R. Young

Text book: How to Write a Publish a Scientific Paper, 7th edition, by Robert A. Day and Barbara Gastel (Greenwood Press, 2011).

1. Specific course information a. Description: Development of biotechnology writing and editorial skills; communication of specialized information to the public and peers. b. Prerequisites: Graduate classification and approval of the instructor. c. BIOT 645 is a required course in the PPiB program 2. Specific goals for the course Upon completing this course, the students will be able to 1. Write more effectively about biotechnology and biotechnology related topics. 2. Strengthen basic writing skills. 3. Learn to present information effectively to the public, peers, and industry. 4. Increase skills in presenting biotechnology information via reports, summaries and abstracts. 5. Enhance abilities to evaluate scientific and technical writing.

List of Topics to be covered

Topics Unit I: Writing Readably

1. Approaching a Writing Project 2. Essential Elements of Editing 3. Editing for Readability

Exercises: Analysis of two pieces of writing in your field that differ in readability Unit I: Writing Readably

1. Basics of Readable Writing 2. Examples of Readable Writing

Exercises: Analysis and Presentation of two pieces of writing that differ in readability

Unit II: Communicating Specialized Information to the Public 1. Basics of Presenting Specialized Information to the Public. 2. Newspaper Coverage of Specialized Fields: Structuring a News Story

Exercise: Describe either how something in your field works or a set of instructions Unit II: Communicating Specialized Information to the Public 1. Presenting Specialized Information via Consumer and Trade Magazines and Newsletters 2. Writing a Feature Story; Some Feature Stories on Specialized Topics Exercise: Analyzing a Magazine; Newspaper stories about new developments in your field; Analysis of such an article with regards to organization, audience and quality of the technical content. Unit II: Communicating Specialized Information to the Public

1. Discussion on writing a feature article on a topic in your field. 2. Current and recent writing assignments 3. Some examples of news releases and related items.

Exercise: an analysis of a consumer magazine or trade magazine in you field Unit II: Communicating Specialized Information to the Public

1. Presenting Specialized Information-Electronically 2. Being Interviewed by Reporters

Exercise: On television, radio or at the World Wide Web be alert for material in your field-note how the material is presented UNIT III: COMMUNICATING SPECIALIZED INFORMATION TO PEERS

1. Scientific Presentations and Posters 2. Some Norms of Scholarly and Professional Communication 3. How Scholarly/Professional Journals Function

Exercise: Prepare a feature article on a topic in your field. UNIT III: COMMUNICATING SPECIALIZED INFORMATION TO PEERS 1. Preparation of Scientific Posters 2. Writing Papers for Journals Exercise: Prepare a constructive critique of the feature article of a classmate. UNIT III: COMMUNICATING SPECIALIZED INFORMATION TO PEERS 1. Presentation by students of their feature ar ticle on the topic in their field 2. Selected Topics in Scientific Communication UNIT III: COMMUNICATING SPECIALIZED INFORMATION TO PEERS

1. Journal Submissions Other Than Scientific 2. Plans for writing a journal article, grant proposal, book chapter, or other

appropriate piece of scholarly/professional writing or an analysis of such a piece Exercise: Interview report on writing done by a scholar or professional in your field UNIT III: COMMUNICATING SPECIALIZED INFORMATION TO PEERS

1. Writing Grant Proposals and Progress Reports 2. Progress on writing a journal article in students specific field 3. Recent and Current writing assignments

Exercise: Write a review of a book of a professional interest to you. Indicate the publication for which the review is intended

UNIT III: COMMUNICATING SPECIALIZED INFORMATION TO PEERS 1. Progress on writing a journal article in students specific field 2. Writing books and book chapters; essential concepts 3. Writing in a Professional Context

UNIT III: COMMUNICATING SPECIALIZED INFORMATION TO PEERS 1. Oral and Written Presentation of Journal Article 2. Writing and Publishing-The Lighter Side 3. Wrap up of all writing exercises for a class

UNIT III: COMMUNICATING SPECIALIZED INFORMATION TO PEERS 1. Additional discussion on the importance of clear, concise, unambiguous writing-

pertinent examples of how to accomplish and not accomplish this feat 2. Discussion of suitable and appropriate titles of manuscript papers, book chapters,

posters and magazine articles 3. Final conclusions on effective scientific communication

BIOT 645 Student Learning Outcomes and PPIB Student Outcomes

BIOT 645 Student Learning Outcomes

PPIB Student Outcomes

1. Write more effectively about biotechnology and biotechnology related topics.

1, 2, 3, 4, 5, 7, 8

2. Strengthen basic writing skills. 1, 2, 3, 5, 7, 8 3. Learn to present information effectively to the public, peers, and industry.

1, 2, 3, 4, 5, 6, 7, 8

4. Increase skills in presenting biotechnology information via reports, summaries and abstracts.

1, 2, 5, 7, 8

5. Enhance abilities to evaluate scientific and technical writing.

1, 2, 3, 5, 6, 7, 8

PROFESSIONAL PROGRAM IN BIOTECHNOLOGY BIOT 681 BIOTECHNOLOGY SEMINAR


Instructor: Victor M. Ugaz

Specific course information a. Description: Review and discussion of current topics in biotechnology

industries, with focus on skills essential to success in the corporate environment such as communication, interviewing and interpersonal skills.

b. Prerequisites: Graduate classification and approval of the instructor. c. BIOT 681 is a required course in the PPiB program Specific goals for the course

By the end of this course, the students will be able to • Describe future challenges to biotechnology in a societal and global context. • Describe the impact of contemporary issues on the biotechnology profession and the

practice of biotechnology • Find, evaluate, and use resources to promote independent learning, including library

resources, computer tools and data bases. • Create and give oral presentations using PowerPoint • Practice oral communication skills and lower the anxiety associated with oral

presentations

Topics

• Presentations by representatives from biotechnology industry and academic

faculty working in biotechnology area

• Presentation needs to deal with a global or societal issue related to biotechnology • From a list developed in class • Other- approved by Instructor

Assignments Seminar Reports: Each student will submit a 1 – 2 page, single-spaced report formatted as follows:

• ~ 1 paragraph about the speaker (who they are, where they work, etc), • short summary of the seminar (at least 1/2 page) • brief discussion of what you thought about the seminar (what aspects of their

work do you find most interesting, do you think the results are important, what questions did you have (at least 1/2 page)

Biotechnology Presentation: Each student will prepare and deliver a 10 – 12 minute oral presentation to the class. Topics will be selected from a list provided in class (others may be suggested by students, subject to instructor approval). Grading

Seminar Reports 50% Oral Presentation 30% Attendance/Participation 20%

Final grades are expected to be distributed according to the following percentage scale: A = 90–100%, B = 80–89%, C = 70–79%, D = 60–69%, F < 59%. BIOT 681 Biotechnology Seminar: Class Schedule

Classes Topics Introduction Presentations/BIOT Industry Rep Presentations/BIOT Industry Rep Presentations/BIOT Faculty Presentations/BIOT Faculty

Presentations/BIOT Industry Rep Presentations/BIOT Industry Rep Presentations/BIOT Industry Rep Presentations/BIOT Faculty Presentations/Field Trip Presentations/Field Trip Presentations/Students No class Presentations/Students Presentations/Students

Relationship of BIOT 681 course objectives to PPiB program outcomes

Course Objectives PPiB Program Outcomes

• Describe future challenges to biotechnology in a societal and global context.

4, 5, 6, 7, 8

• Describe the impact of contemporary issues on the biotechnology profession and the practice of biotechnology

8

• Find, evaluate, and use resources to promote independent learning, including library resources, computer tools and data bases.

3, 7

• Create and give oral presentations using PowerPoint 7 • Practice oral communication skills and lower the anxiety

associated with oral presentations 7

PROFESSIONAL PROGRAM IN BIOTECHNOLOGY BIOT 684 BIOTECHNOLOGY PROFESSIONAL INTERNSHIP


Instructor/Faculty Supervisor: BIOT FACULTY

Specific course information a. Description: A directed internship in an organization that provides on-the-job

training with professionals in organizational settings appropriate to the student's professional objectives. May be taken two times for credit.

b. Prerequisites: Approval of the Chair of the Faculty of Biotechnology c. BIOT 684 is a required course in the PPiB program Specific goals for the course

By the end of this course, the students will be able to • Participate in customized training/directed internship in a biotechnology company • Describe future challenges to biotechnology in a societal and global context • Describe the impact of contemporary issues on the biotechnology profession and the

practice of biotechnology • Find, evaluate, and use resources to promote independent learning, including library

resources, computer tools and data bases. • Practice oral communication skills and lower the anxiety associated with oral

presentations All BIOT students are required to complete BIOT 684 Learning Agreement, BIOT 684 Internship Description Form and submit offer letter prior to registration.

Texas A&M University Professional Program in Biotechnology Learning Agreement

This agreement between (insert student and company names) and the Texas A&M Professional Program in Biotechnology provides a listing of responsibilities of the various parties involved and the specific learning objectives or goals of the student during the internship experience.

RESPONSIBILITIES UNDER THIS AGREEMENT: Faculty Advisor (Committee Chair):

• Help formulate the student’s learning objectives. • Meet with the student to provide guidance and support prior to the internship. • Assess the student’s learning based on predetermined objectives and evaluation

criteria outlined in the BIOT 684 Internship and Portfolio Handbook. • Provide telephone and e-mail follow-up as needed throughout the internship to

provide guidance and support. Site Supervisor:

• Help formulate the student’s learning objectives. • Provide direction to help the student achieve the learning objectives. • Complete a midterm and final evaluation of the student and return forms to the

PPiB Coordinator. • Assume responsibility for the student’s supervision during the internship. • Review student presentation for confidential material and send memo to PPiB

Coordinator. Student:

• Register for BIOT 684 after providing the Internship Description Form, offer letter and signed Learning Agreement to the PPiB Coordinator.

• Perform the tasks and responsibilities assigned by your site supervisor. • Follow the rules and regulations of the business or agency. • Consult with your faculty advisor regarding any changes or problems that arise

during your internship experience. • Complete the Student Evaluation of Site form and return to the PPiB

Coordinator. Professional Program in Biotechnology Coordinator:

• Help formulate the student’s learning objectives. • Add section of BIOT 684 for student once paperwork is received. • Act as a liaison for the university, work site, faculty advisor, and student. • Assist faculty advisor, site supervisor, and student with any difficulties.

LEARNING OBJECTIVES: (Insert a list of the broad learning objectives you will achieve during your internship, including specific activities, due dates, and evaluation methods that will be used. Set realistic goals that can be documented.)

Your signature means you have read and agreed to the responsibilities listed for your role in this Learning Agreement.

Student Intern Date:

Site Supervisor Date:

Faculty Advisor Date:

Program Coordinator

Date:

Texas A&M University Professional Program in Biotechnology

Internship Description Form Student Name: UIN: Internship semester: Mobile phone: e-mail address: Company Name: Address 1: Address 2: City, state, zip code: Web address: Telephone: Fax: Supervisor Name: Title: Telephone: e-mail: Internship Dates: Position title: Position description: Salary: Save your document and send as an e-mail attachment to [email protected] Also attach a copy of your internship offer letter.



• Participate in customized training/directed internship in a biotechnology company

1, 2, 3, 4, 5, 6, 7, 8

• Describe future challenges to biotechnology in a societal and global context

8


3, 7

• Find, evaluate, and use resources to promote independent learning, including library resources, computer tools and data bases

7

• Practice oral communication skills and lower the anxiety associated with oral presentations

7

PROFESSIONAL PROGRAM IN BIOTECHNOLOGY BIOT 685 BIOTECHNOLOGY DIRECTED STUDIES

Credits and contact hours: Credit 1.0-4.0 (required 3.0)

Instructor: BIOT FACULTY

Specific course information a. Description: Provides customized training and experience to students in the

Biotechnology Program; topics can include laboratory research, scientific literature reviews, biotechnology market surveys, and training in technology commercialization.

b. Prerequisites: Graduate classification and approval of the instructor. c. BIOT 685 is a required course in the PPiB program Specific goals for the course

By the end of this course, the students will be able to

• Participate in customized training and experience in biotechnology research • Enhance laboratory research skills, marketing skills, and teambuilding skills. • Describe the impact of contemporary issues on the biotechnology profession and

the practice of biotechnology • Find, evaluate, and use resources to promote independent learning, including

library resources, computer tools and data bases. • Create and give oral presentations using PowerPoint and prepare research posters • Practice oral communication skills and lower the anxiety associated with oral

presentations through participation in BIOT Annual Research Conference

BIOT students are required to complete BIOT 685 Directed Studies form prior to registration.

BIOT 685 – Directed Studies in Biotechnology Project Establishment Form

Date: _________________ Project Information Student’s name: ______________________________________ Instructor: ________________________________________________ Semester when project will be performed: _______________________ Weekly time commitment expected (hrs/week): __________________ Project title: __________________________________________________________________________________ Description of Project Please attach a brief description of the research project, the problem to be studied, the student’s role in performing the study, and what outcomes are expected upon completion of the project. This description should be prepared by the student with guidance from the instructor, and should be crafted to provide practical training relevant to the professional nature of the BIOT degree. Course Description BIOT 685. Directed Studies. Credit 1-4. Provides customized training and experience to students in the Biotechnology Program; topics can include laboratory research, scientific literature reviews, biotechnology market surveys, and training in technology commercialization. Prerequisites: approval of instructor. Project Deliverables The basis for the assigned grade will be: _______________________________________________ ________________________________________________________________________________ Signatures/Approval ________________________ ________________________ _____________________ Student Researcher Instructor BIOT 685 BIOT Committee Chair



• Participate in customized training and experience in biotechnology research

1, 2, 3, 4, 5, 6, 7, 8

• Enhance laboratory research skills, marketing skills, and teambuilding skills

1, 3


3, 7

• Find, evaluate, and use resources to promote independent learning, including library resources, computer tools and data bases

7, 8

• Create and give oral presentations using PowerPoint and prepare research posters

7, 8

• Practice oral communication skills and lower the anxiety associated with oral presentations through participation in BIOT Annual Research Conference

7, 8

Appendix B

Student Development Conference Agendas

ProfessionalPrograminBiotechnology

2011AdvisoryCouncilStudentDevelopmentConference

Friday,November18,2011TexasA&MUniversity4thFloor,RudderTower

BriefAgenda

10:00-10:30AM WelcomeandAnnouncements,Room401

10:30AM-12:00PM

CareerExploration:ConcurrentSessionswithAdvisoryCouncilMembersinR&D,Room402;RegulatoryAffairs,Room404;andTechnologyTransfer,Sales&Marketing,Room407A

12:00-12:30PM Lunch,Room401

12:30-12:45PM

ReconveneandAnnouncements,Room401

12:45-2:30PM StudentInternshipPresentationsbyDecemberGraduates,Room401

2:30-3:00PM OutstandingGraduateAward,Photos,&Closing,Room401

3:30-4:00PM TouroftheNationalCenterforTherapeuticsManufacturingforAdvisoryCouncilMembers(tentative)

DetailedAgenda

MorningSession:CareerExplorationwithAdvisoryCouncilMembersRoom402.R&DandProductDevelopmentwithmembers:NathanHarris,LifeTechnologies,AustinMichaelaHoffmeyer,Luminex,AustinStevenNavran,Synthecon,Houston

• 10:30-11:00AM—StudentgroupA• 11:00-11:30AM—StudentgroupB• 11:30AM-12:00PM—StudentgroupC

Room404.RegulatoryAffairsandGeneralQuestionswithmembers:PamMabry,HumanResourcesConsultant,HoustonDalalMurgai,RegulatoryOutsourceConsulting,TheWoodlandsSushilSharma,U.S.GovernmentAccountabilityOffice,Washington,DCJanetVarela,KellyScientificResources,Houston

• 10:30-11:00AM—StudentgroupB• 11:00-11:30AM—StudentgroupC• 11:30AM-12:00PM—StudentgroupA

Room407A.TechnologyTransfer,SalesandMarketingwithmembers:TimNovak,Sigma-Aldrich,HoustonMichaelDilling,BaylorLicensingGroup,HoustonPeterSchuerman,TAMUSLicensing&IPManagement,CollegeStation

• 10:30-11:00AM—StudentgroupC• 11:00-11:30AM—StudentgroupA• 11:30AM-12:00PM—StudentgroupB

AfternoonSession:StudentPresentations

12:45-1:00PM MaryamAnsari,Agennix,Houston1:00-1:15PM JayashreeChandrasekharan,TAMUHealthScienceCenter,CollegeStation1:15-1:30PM AllanKotzot,OpexaTherapeutics,TheWoodlands1:30-1:45PM HamzaMohammed,TAMUSOfficeofTechnologyCommercialization1:45-2:00PM ReubenSequeira,NewEnglandBiolabs,Ipswich,MA2:00-2:15PM MichaelSutton,CSBio,MenloPark,CA2:15-2:30PM EstelaVonChong,PlxPharma,Houston



Friday,April27,2012TexasA&MUniversity

Room401,RudderTower

Agenda

9:15-9:30AM9:30-10:00AM

ArrivalWelcomeandProgramUpdate—VictorUgaz

10:00-10:30AM BIOTCurriculum:ScienceFoundationBIOT601—EleanoreConantBIOT635—ClareGillBIOT645—ColinYoungBIOT681—GusCothranBIOT685—VictorUgaz

10:30-10:45AM10:45-11:00AM

Q&A—ScienceFacultyBreak

11:00-11:30AM

BIOTCurriculum:BusinessPlusCoursesACCT640—AdamMyersFINC635—WendyGalpinMGMT655/658—VickieBuengerMKTG621—LarryGreshamCertificateofEntrepreneurship—DickLester

11:00-11:45AM

Q&A—BusinessFaculty

11:45AM-1:00PM Lunch


1:00-1:15PM FisherChih-ShengChang,Dept.ofSoil&CropScience,TAMU1:15-1:30PM DilsherDhillon,TexasAgriLifeGenomics&BioinformaticsService1:30-1:45PM JohnLowderman,TAMUSOfficeofTechnologyCommercialization1:45-2:00PM

2:00-2:15PM

ShehnazLokhandwala,Dept.ofVeterinaryPathobiology,TAMUBreak

2:15-2:30PM2:30-2:45PM

MeghnaMuralidhar,Dept.ofChemistry,TAMUPayalShah,LuminexCorporation,Austin

2:45-3:00PM JunjieSong,Terrabon,CollegeStation3:00-3:15PM

3:15-3:30PM

SpandanaValluru,InstituteofBiosciences&Technology,TAMUPresentationofStudentAwards,GroupPhotos



Friday,November16,2012TexasA&MUniversity

MemorialStudentCenter

BriefAgenda

9:15-9:30AM9:30-10:00AM

Arrival;PickUpConferenceMaterials,Room2500WelcomeandProgramUpdate,Dr.VictorUgaz,Room2500

10:00-10:15AM OnlineCertificateinRegulatoryScience,Dr.TimHerrman,Room2500

10:15-10:30AM Break

10:30AM-12:00PM

CareerExplorationRotations:ConcurrentSessionswithAdvisoryCouncilMembersinR&D,Room2501;RegulatoryAffairs&Quality,Room2502;andTechnologyTransfer,Sales&Manufacturing,Room2503

12:00-1:00PM NetworkingLunch,Rooms2500-2503

1:00-1:15PM ConferencePhotos,2500WingCommonArea


2:00-2:15PM Break


2:45-3:15PM OutstandingGraduateAward,Evaluations,andClosing,Room2500

DetailedAgenda

MorningSession:CareerExplorationwithAdvisoryCouncilMembersRoom2501.R&DandProductDevelopmentwithmembers:ChrisBurnett,LifeTechnologies,AustinMichaelaHoffmeyer,Luminex,AustinSusanMagdaleno,LifeTechnologies,Austin

• 10:30-11:00AM—StudentgroupA• 11:00-11:30AM—StudentgroupB• 11:30AM-12:00PM—StudentgroupC

Room2502.RegulatoryAffairsandQualitywithmembers:JohnFerreira,KalonBiotherapeutics,CollegeStationDeepthiMikkili,Allergan,Irvine,CABarbaraSmith,LexiconPharmaceuticals,TheWoodlands

• 10:30-11:00AM—StudentgroupB• 11:00-11:30AM—StudentgroupC• 11:30AM-12:00PM—StudentgroupA

Room2503.TechnologyTransfer,SalesandManufacturingwithmembers:TimNovak,Sigma-Aldrich,HoustonBillReed,KalonBiotheratpeutics,CollegeStationPeterSchuerman,TAMUSLicensing&IPManagement,CollegeStation

• 10:30-11:00AM—StudentgroupC• 11:00-11:30AM—StudentgroupA• 11:30AM-12:00PM—StudentgroupB


1:20-1:30PM JoshFritz,KalonBiotherapeutics,CollegeStation1:30-1:40PM AparnaKrishnan,LifeTechnologies,Austin1:40-1:50PM ElsiePonce,KalonBiotherapeutics,CollegeStation1:50-2:00PM ManishRathi,TAMUSOfficeofStrategicInitiatives,CollegeStation2:15-2:25PM PallavShah,KalonBiotherapeutics,CollegeStation2:25-2:35PM ManishThakran,OpexaTherapeutics,TheWoodlands2:35-2:45PM AbhiramThatipelli,Luminex,Austin



Friday,February8,2013 TexasA&MUniversity

Room120,NationalCenterforTherapeuticsManufacturing

Agenda

10:00-10:20AM10:20-10:30AM10:30-10:50AM

Coffeeandregistration,NCTMfoyerWelcomeandintroductionsAgricultureBiotechnologyTyWitten,GlobalCotton,Specialty&VegetableRegulatoryAffairsLead,MonsantoCo.,St.Louis,MO

10:50-11:10AM PerspectiveofanIndependentRegulatoryConsultantDalalMurgai,President,RegulatoryOutsourceConsulting,Inc.,TheWoodlands,TX

11:10-11:30AM EntrepreneurialBiotechnologyMimiHealy,CEO,LaserGen,Inc.,Houston,TX

11:30AM-12:00PM12:00-1:00PM

Q&AsessionwithmorningspeakersNetworkinglunch,NCTMfoyer

1:00-1:20PM ChallengingCareersinthePharmaceutical/BiotechIndustry

GaryKrishnan,ChiefScientificOfficer,Musculoskeletal&UrologyDivision,LillyResearchLaboratories,Indianapolis,IN

1:20-1:40PM1:40-2:00PM2:00-2:30PM2:30-2:40PM

InstituteforAppliedCancerScience(IACS):OpportunitiesforDrugDiscoveryInternshipsandBeyondJannikAndersen,SeniorAssociateDirector—DrugDiscoveryBiology,IACS,MDAnderson,Houston,TXUnderstandingConsumerBehavior:ThePowerofMarketResearchandApplicationstoYourPersonalBrandPaulineKrinov,BlackBelt,BusinessProcessImprovement,Nielsen,Cincinnati,OHQ&AsessionwithafternoonspeakersConferenceclosingandevaluations

ProfessionalPrograminBiotechnologyTexasA&MUniversity

2014StudentDevelopmentConferenceandAdvisoryCouncilMeetingFriday,February28,2014

MemorialStudentCenter(MSC)Room2500

Agenda

8:30am-9:00am Arrival;pickupconferencematerials;infrontofRoom2500

9:00am-9:15am WelcomeRoom2500

9:15am-10:15am AdvisoryCouncilmemberspresentationsRoom2500

10:30am-noon RotationSessionsRooms2501,2502,2503

12:00-12:45pm Lunch

12:45pm-1:15pm AnnouncementsandPhotos

1:15pm-2:00pm AdvisoryCouncilmemberspresentationsRoom2500

2:00pm-2:15pm Announcements&ClosingRoom2500

DetailedAgenda

8:30am-9:00am Arrival;pickupconferencematerials;infrontofRoom25009:00am-9:15am WelcomeVictorUgazRoom25009:15am-9:30am TysonFetzer,BaxterBioScience,California9:30am-9:45am ChristieSayes,RTIInternational,NorthCarolina9:45am-10:00am JohnFerreira,BlinnCollege,Texas10:00am-10:15am SusanMagdaleno,LifeTechnologies,Texas10:30am-noon RotationSessions

R&D&ProductDevelopment,Room2501ChristieSayes&SusanMagdaleno10:30am-11:00amStudentGroupA11:00am-11:30amStudentGroupB11:30am-12:00StudentGroupC

RegulatoryAffairsandGeneralQuestions,Room2502

BarbaraSmith,TyWitten&JohnFerreira10:30am-11:00amStudentGroupB11:00am-11:30amStudentGroupC11:30am-12:00StudentGroupA

TechnologyTransfer,SalesandMarketing,Room2503

TysonFetzer&MadisonMauze10:30am-11:00amStudentGroupC111:00am-11:30amStudentGroupA11:30am-12:00StudentGroupB

12:00-12:45pm Lunch12:45pm-1:15pm AnnouncementsandPhotos1:15pm-1:30pm BarbaraSmith,B.ThomasSmith,LLC,Texas1:30pm-1:45pm MadisonMauze,CelltexTherapeuticsCorporation,Texas1:45pm-2:00pm TyWitten,MonsantoCompany,Missouri2:00pm-2:15pm AnnouncementsandClosing


TexasA&MUniversity

Fall2014StudentDevelopmentConferenceandAdvisoryCouncilMeeting

Monday,November24,2014

Coca-ColaNorthAmerica

2150TownSquarePlaceSuite400

SugarLand,Texas77479

Agenda

10:00am-10:30amArrivalRoom400

10:30am-10:45amWelcomeRoom4105B/C

10:45am-11:45amAdvisoryCouncilmemberspresentationsRoom4105B/C

11:45am-12:30pmLunch

12:30pm-1:30pmAdvisoryCouncilmemberspresentationsRoom4105B/C

1:30pm-1:45pmPanelDiscussionQ&ARoom4105B/C

1:45pm-2:00pmPicturesAnnouncementsClosingRoom4105B/C

2:30pm-3:30pmFieldtriptoCelltexTherapeuticsCorporation(2401FountainViewDrive,Houston,TX,77057)

DetailedAgenda

10:00am-10:30am ArrivalRoom40010:30am-10:45am WelcomeVictorUgazRoom4105B/C10:45am-11:15am CodyWilson,SeniorDirector,FoodSafetyCenterofExcellence,TheCoca-Cola

Company,Atlanta,GA11:15am-11:45am MikeSaintJohn,GeneralManager,MinuteMaidBusinessUnit,TheCoca-Cola

Company,Houston,TX11:45am-12:30pm Lunch12:30pm-12:45pm BarbaraThomasSmith,President,B.ThomasSmithLLC,Houston,TX12:45pm-1:00pm WilliamReed,SeniorVicePresident,Operation,KalonBiotherapeutics,College

Station,TX1:00pm-1:15pm MadisonMauze,VicePresidentBusinessDevelopment,CelltexTherapeutics

Corporation,Houston,TX1:15pm-1:30pm DalalMurgai,RegulatoryOutsourceConsulting,Inc.,Houston,TX1:30pm-1:45pm PanelDiscussion,Q&A1:45pm-2:00pm PicturesAnnouncementsClosing

Spring 2016 Student Development Conference and Advisory Council meeting

Thursday, February 25, 2016

Memorial Student Center (MSC)

Brief Agenda

9:00am-9:30am Arrival; Pick-up conference materials ROOM 2501 9:30am-10:00am Welcome and Program Update Dr. Victor Ugaz, ROOM 2501 10:00am-10:15am Break 10:15am-12:00noon Career Exploration Rotations: Concurrent Sessions with Advisory Council

Members ROOM 2503 and ROOM 2504 12:00noon-1:00pm Networking Lunch ROOM 2503 and ROOM 2504 1:00pm-1:15pm Conference photos Common Area ROOM 2501 1:15pm-2:25pm May Graduates Student Presentations ROOM 2501 2:30pm-2:45pm Break 2:45pm-3:00pm Outstanding Graduate Award; Closing ROOM 2501

Detailed Agenda

10:15am-12:00noon Career Exploration Rotations

ROOM 2503 Sylvain Marcel, Senior Scientist, IBIO, Inc., Bryan, TX Ty Witten, Cotton, Soybean, Specialty Crop, and Seed Treatment Systems Lead, Monsanto, St. Louis, MO Christie Sayes, Associate Professor of Environmental Science, Baylor University, Waco, TX Venkatesh Krishnan, Chief Scientific Officer, Eli Lilly and Company, Indianapolis, IN 10:15am-11:00am Student Group A 11:00am-11:45am Student Group B ROOM 2504 John Ferreira, Quality Systems Consultant, Therapeutics Mfg, Banziger Systems, LLC, Bryan, TX Tyson Fetzer, Senior Manager of Manufacturing, Genzyme, Boston, MA Cody Wilson, Senior Director, Food Safety Center of Excellence, Coca-Cola, Atlanta, GA Susan Magdaleno, R&D Senior Manager, Scientist, Thermo Fisher Scientific, Austin, TX 10:15am-11:00am Student Group B 11:00am-11:45am Student Group A

1:15pm-2:25pm May Graduates Student Presentations ROOM 2501 1:15pm-1:25pm Gipshu Dave, Zoetis, Inc., Durham, North Carolina 1:25pm-1:35pm Saanika More, Texas A&M System Office of Technology Commercialization, College Station, Texas 1:35pm-1:45pm Prahelika Reddy, Institute of Biosciences and Technology, TAMU, Houston, Texas & Affymetrix, Cleveland, Ohio 1:45pm-1:55pm Jared Conrad, Nanohmics, Inc., Austin, Texas and Texas A&M System Office of Technology Commercialization, College Station, Texas 1:55pm-2:05pm Keshav Karki, Department of Veterinary Physiology and Pharmacology, TAMU, College Station, Texas 2:05pm-2:15pm Janae Rapp, MD Anderson Cancer Center, Houston, Texas 2:15pm-2:25pm Qianwen Ouyang, Veterinary Integrative Biosciences Department, TAMU, College Station, Texas

Spring 2017 Student Development Conference and Advisory Council meeting

Friday, February 10, 2017

Memorial Student Center (MSC)

Brief Agenda

9:00am-9:30am Arrival; Pick-up conference materials ROOM 2501 9:30am-10:00am Welcome and Program Update Dr. Victor Ugaz, ROOM 2501 10:00am-10:15am Break 10:15am-12:00noon Career Exploration Rotations: Concurrent Sessions with Advisory Council

Members ROOM 2502 and ROOM 2503 12:00noon-1:00pm Networking Lunch ROOM 2502 and ROOM 2503 1:00pm-1:15pm Conference photos Common Area ROOM 2501 1:15pm-2:35pm May Graduates Student Presentations ROOM 2501 2:35pm-3:00pm Break 3:00pm-3:15pm 3:15pm-3:30pm

Outstanding Graduate Award; ROOM 2501 Debriefing/AC members

Detailed Agenda

10:15am-12:00noon Career Exploration Rotations

ROOM 2502 Nathan Dewsbury, Owner/GM, Novis Animal Solutions, LLC, College Station, TX John Ferreira, VP Quality Operations, Business Development, MDx BioAnalytical Laboratory, Inc., College Station, TX Venkatesh Krishnan, Chief Scientific Officer, Eli Lilly and Company, Indianapolis, IN Deepthi Mikkili, Manager, Clinical Data Management, Amgen, Thousand Oaks, CA Christie Sayes, Associate Professor of Environmental Science, Baylor University, Waco, TX 10:15am-11:00am Student Group A 11:00am-11:45am Student Group B ROOM 2503 John Madsen, Head of Process Development Operations, FUJIFILM Diosynth Biotechnologies Texas, LLC College Station, TX Rana Gunjot, Global Product Manager, Global Marketing, Luminex Corp., Austin, TX Susan Magdaleno, R&D Senior Manager, Scientist, Thermo Fisher Scientific, Austin, TX Sylvain Marcel, Senior Scientist, iBio CMO, LLC, Bryan, TX Benjamin Yaden, Senior Research Scientist, Eli Lilly and Company, Indianapolis, IN 10:15am-11:00am Student Group B 11:00am-11:45am Student Group A

1:15pm-2:45pm May Graduates Student Presentations ROOM 2501 1:15pm-1:25pm Catherine Wellman, Gilead Sciences, Foster City, CA 1:25pm-1:35pm Ketki Patil, Luminex Corp., Austin, TX 1:35pm-1:45pm Anu Balakavi, Xybion Corporation, Bensalem, PA 1:45pm-1:55pm Xiyuan Wang, MD Anderson Cancer Center, Houston, TX 1:55pm-2:05pm Karat Sidhu, Center for Translational Research in Aging and Longevity, Texas A&M

University, College Station, TX 2:05pm-2:15pm Nithisha Khasnavis, MD Anderson Cancer Center, Houston, TX 2:15pm-2:25pm Rohit Rohra, Kleberg Animal and Food Science Center, Texas A&M University,

College Station, TX 2:25pm-2:35pm Ishita Bansal, ST Genetics, Navasota, TX

Appendix C

WEAVE Online Report for the 2015 – 2016 Academic Assessment Cycle


Detailed Assessment Report2015-2016 Biotechnology, MBIOT

As of: 2/24/2017 02:00 AM CST(Includes those Action Plans with Budget Amounts marked One-Time, Recurring, No Request.)

Mission / PurposeThe mission of Professional Program in Biotechnology at Texas A&M is to educate andprepare students for national and international leadership roles in industry, business,academia and government; to attract top graduate students to professional sciencemaster’s degree in biotechnology; to develop new directions in biotechnology engineeringeducation and curriculum; to be a valuable resource and service base to the State and thebiotechnology profession; and to prepare students to solve problems of social andeconomic importance.

Goals

G 1: Career Preparation PPiB graduates will have foundation for breadth and depth across the range of advancedscience, business and engineering topics for successful biotechnology careers in industry,business, academia and government.

G 2: Communication, Leadership, and Teamwork PPiB graduates will be effective communicators and have appropriate leadership, projectmanagement and teamwork skills.

G 3: Integrity and Professional Impact PPiB graduates will have a sense of responsibility and ethical conduct to their professionand an appreciation for the impact of their profession on society both nationally andinternationally.

Student Learning Outcomes/Objectives, with Any Associations andRelated Measures, Targets, Findings, and Action Plans

SLO 1: Applied Biological Science Techniques in Practice Graduates will have an ability to apply knowledge of advanced biological sciences and touse the scientific techniques and tools necessary for biotechnology practice.

Relevant Associations:Graduate Outcome Associations

1.2 Apply subject matter knowledge in a range of contexts to solve problems andmake decisions.

Strategic Plan AssociationsTexas A&M University

2 Strengthen our graduate programs.

Related Measures

M 1: Final Exam Evaluation Rubric

Content in the final exam will be evaluated using the attached rubric.Source of Evidence: Writing exam to assure certain proficiency levelConnected Document

Final Evaluation Form

Target: Average rating will exceed 2.0 on a 4.0 scale on ability related to the question.

Finding (2015-2016) - Target: MetAverage Score 3.6 EXCEEDS Expectations

Related Action Plans (by Established cycle, then alpha):For full information, see the Details of Action Plans section of this report.

Provide additional opportunities to enhance communication skillsEstablished in Cycle: 2013-2014Based upon student feedback from a pilot effort last year, graduatingstudents present a final oral reflection modeled on the un...

Implement new assessment rubricsEstablished in Cycle: 2014-2015In summary, PPIB has strengthened its evaluation and assessment efforts.Program educational objectives and outcomes are revie...

Establish new PPiB Lecture Series: New Technologies and InnovationsEstablished in Cycle: 2015-2016We are working to establish a new lecture series aimed at exposingstudents to cutting-edge technologies and innovations in the ...

M 2: Co-op/Internship data/EvaluationsStudents are evaluated for co-ops/internships at the completion of a compulsory BIOT684. They are evaluated by their professional internship supervisors.Source of Evidence: Field work, internship, or teaching evaluationConnected Document


Target: 100% of students will be evaluated at “2” meets expectations and above on abilityrelated to the question.




M 4: Alumni SurveyEvery three years, Professional Program in Biotechnology will conduct regular alumnisurveys. We poll alumni for their views on the utility of the program and itsweaknesses and strengths. The surveys of program alumni will be undertaken duringSpring 2017. The survey questions will be mapped to three Program EducationalObjectives. In the alumni survey, the alumni indicate how successful they are in theircareers and in the various areas covered by the survey questions. We expect that

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alumni participating in the survey will indicate that they are satisfied with the program.For the alumni survey, the criterion for success is 3.5 on the scale 1-―StronglyDisagree to 5-―Strongly Agree.Source of Evidence: Alumni survey or tracking of alumni achievements

Target: The average alumni response will be that they engage in team work at 3.5 on a 5point likert scale.

Finding (2015-2016) - Target: MetEvery three years, Professional Program in Biotechnology will conduct regularalumni surveys. We poll alumni for their views on the utility of the program andits weaknesses and strengths. The surveys of program alumni will beundertaken during Spring 2017. The survey questions will be mapped to threeProgram Educational Objectives. In the alumni survey, the alumni indicate howsuccessful they are in their careers and in the various areas covered by thesurvey questions. We expect that alumni participating in the survey will indicatethat they are satisfied with the program. For the alumni survey, the criterion forsuccess is 3.5 on the scale 1-―Strongly Disagree to 5-―Strongly Agree.Currently based on the data from job placement we will consider thisassessment measure completed.


Enhance professional development opportunitiesEstablished in Cycle: 2013-2014Based upon feedback from our student satisfaction surveys, we are workingto provide a wider variety of professional development...

SLO 2: Applied Biological Science Techniques in Profession Students will have an ability to apply knowledge and skills of leadership, business andmanagement in the biotechnology profession.





Related Measures

M 1: Final Exam Evaluation RubricContent in the final exam will be evaluated using the attached rubric.Source of Evidence: Writing exam to assure certain proficiency levelConnected Document




Related Action Plans (by Established cycle, then alpha):


For full information, see the Details of Action Plans section of this report.








M 4: Alumni SurveyEvery three years, Professional Program in Biotechnology will conduct regular alumnisurveys. We poll alumni for their views on the utility of the program and itsweaknesses and strengths. The surveys of program alumni will be undertaken duringSpring 2017. The survey questions will be mapped to three Program EducationalObjectives. In the alumni survey, the alumni indicate how successful they are in theircareers and in the various areas covered by the survey questions. We expect thatalumni participating in the survey will indicate that they are satisfied with the program.For the alumni survey, the criterion for success is 3.5 on the scale 1-―StronglyDisagree to 5-―Strongly Agree.Source of Evidence: Alumni survey or tracking of alumni achievements





Comparison of internship satisfaction surveysEstablished in Cycle: 2010-2011We will compare responses of students to a survey evaluating internshipsites completed immediately following the summer interns...

SLO 3: Analyze and Interpret Data PPiB students will have an ability to analyze and interpret data.


1.3 Use a variety of sources and evaluate multiple points of view to analyze andintegrate information and to conduct critical, reasoned arguments.



Related Measures



















SLO 4: Function on Multidisciplinary Teams PPiB students will have an ability to function on multidisciplinary teams.



Related Measures









SLO 5: Solve Problems Important in Biotechnology Practice PPiB students will have an ability to identify, formulate, and solve problems important inbiotechnology practice.





Related Measures
















Target: The average alumni response will be that they are successful in their careers at 3.5on a 5 point likert scale.




SLO 6: Professional and Ethical Responsibility PPiB students will have an understanding of professional and ethical responsibility.


1.7 Choose ethical courses of action in research and practice.Strategic Plan Associations

Texas A&M University2 Strengthen our graduate programs.

Related Measures














Target: The average alumni response will be that they are leaders in their field at 3.5 on a5 point likert scale.






SLO 7: Communicate Effectively PPiB students will have an ability to communicate effectively.


1.4 Communicate effectively.Strategic Plan Associations

Texas A&M University2 Strengthen our graduate programs.

Related Measures







M 2: Co-op/Internship data/EvaluationsStudents are evaluated for co-ops/internships at the completion of a compulsory BIOT684. They are evaluated by their professional internship supervisors.


Source of Evidence: Field work, internship, or teaching evaluationConnected Document







Target: Alumni report that they are effective communicators at 3.5 on a 5 point likert scale.




SLO 8: Understand Contextual Impact of Biotechnology PPiB students will have an understanding of the impact of biotechnology practice in ascientific, economic and societal context.






Related Measures







Establish new PPiB Lecture Series: New Technologies and InnovationsEstablished in Cycle: 2015-2016We are working to establish a new lecture series aimed at exposingstudents to cutting-edge technologies and innovations in the ...










Target: Alumni report that they engage in professional activities that impact society at 3.5on a 5 point likert scale.




SLO 9: Job Placement PPiB students will be employed or seeking further graduate work at time of graduation.

Related Measures

M 3: Post Graduation Plans Survey/DataStudents complete a feedback survey electronically upon completion of the program.Source of Evidence: Exit interviews with grads/program completers

Target: 70% of respondents will report that they have been placed in a job or graduateschool.

Finding (2015-2016) - Target: MetBased on a survey of data from Professional Program in Biotechnologystudents who graduated in December/May 2015-2016 (19 students) 94% ofstudents have been placed in a job or graduate school (includes two studentsto graduate schools).




Target: 70% of respondents will report that they have been placed in a job or graduateschool.

Finding (2015-2016) - Target: MetBased on a survey of data from Professional Program in Biotechnologystudents who graduated in December/May 2015-2016 (19 students) 94% ofstudents have been placed in a job or graduate school (includes two studentsto graduate schools).

Details of Action Plans for This Cycle (by Established cycle, then alpha)Comparison of internship satisfaction surveys

We will compare responses of students to a survey evaluating internship sitescompleted immediately following the summer internship with the ranking of theinternship experience on the graduate satisfaction survey completed several yearslater. The survey immediately following the internship may differ significantly from laterreflection on the experience although it is hoped that results will be consistent.Established in Cycle: 2010-2011Implementation Status: In-ProgressPriority: High

Relationships (Measure | Outcome/Objective):Measure: Alumni Survey | Outcome/Objective: Applied Biological ScienceTechniques in Profession

Additional Resources: noneEnhance professional development opportunities

Based upon feedback from our student satisfaction surveys, we are working to providea wider variety of professional development opportunities for our students. Currently ,allparticipate in an on-campus day-long professional development conference in thespring. We are currently in the second year of implementation of a spring BIOT DirectedStudies Poster Symposium, where students have an opportunity to present the resultsfrom their directed studies projects to faculty and external judges. Awards are given foroutstanding presentations. We are working to implement a new poster session in thefall aimed at students who have completed internships, to provide a forum for them toshowcase accomplishments during their required internship experiences.Established in Cycle: 2013-2014Implementation Status: In-Progress

Priority: High

Relationships (Measure | Outcome/Objective):Measure: Alumni Survey | Outcome/Objective: Applied Biological ScienceTechniques in Practice

Increase domestic student recruitmentBased on our enrollment data trends, we continue to explore ways to recruit domesticstudents. This year, we made early financial support offers in an effort to encourageearly acceptance of admissions offers. We are currently evaluating the effectiveness ofthis initiative.Established in Cycle: 2013-2014Implementation Status: In-ProgressPriority: High

Provide additional opportunities to enhance communication skillsBased upon student feedback from a pilot effort last year, graduating students presenta final oral reflection modeled on the university-level 3 minute thesis competition. Wehave also implemented a spring directed studies poster session, and are working toimplement a fall internship poster showcase.Established in Cycle: 2013-2014Implementation Status: In-ProgressPriority: High

Relationships (Measure | Outcome/Objective):Measure: Final Exam Evaluation Rubric | Outcome/Objective: AppliedBiological Science Techniques in Practice

Implement new assessment rubricsIn summary, PPIB has strengthened its evaluation and assessment efforts. Programeducational objectives and outcomes are reviewed and updated. New departmentaland exam assessment techniques have been developed and will be implemented (newfinal exam assessment rubric, suitable mid term and final evaluation rubrics forinternships, new post graduation plans survey and alumni survey forms). PPIBprepares program assessment reports (PARs) every year. The results of PARs reportsare entered into Texas A&M University-wide repository of assessment informationsystem ―WEAVE ONLINE.Established in Cycle: 2014-2015Implementation Status: In-ProgressPriority: High

Relationships (Measure | Outcome/Objective):Measure: Alumni Survey | Outcome/Objective: Communicate Effectively| Function on Multidisciplinary Teams | Professional and EthicalResponsibility | Solve Problems Important in Biotechnology Practice |Understand Contextual Impact of BiotechnologyMeasure: Co-op/Internship data/Evaluations | Outcome/Objective:Analyze and Interpret Data| Applied Biological Science Techniques in Practice | Applied BiologicalScience Techniques in Profession | Communicate Effectively | Function onMultidisciplinary Teams | Professional and Ethical Responsibility | SolveProblems Important in Biotechnology Practice | Understand ContextualImpact of BiotechnologyMeasure: Final Exam Evaluation Rubric | Outcome/Objective: Analyzeand Interpret Data| Applied Biological Science Techniques in Practice | Applied BiologicalScience Techniques in Profession | Communicate Effectively | Function on

Multidisciplinary Teams | Professional and Ethical Responsibility | SolveProblems Important in Biotechnology Practice | Understand ContextualImpact of BiotechnologyMeasure: Post Graduation Plans Survey/Data | Outcome/Objective: JobPlacement

Establish new PPiB Lecture Series: New Technologies and InnovationsWe are working to establish a new lecture series aimed at exposing students to cutting-edge technologies and innovations in the biotechnology field. Our first planned guestspeaker for Fall 2016 will be Mr. Justin Liao from Thermo Fisher Scientific, CA.Established in Cycle: 2015-2016Implementation Status: PlannedPriority: High

Relationships (Measure | Outcome/Objective):Measure: Final Exam Evaluation Rubric | Outcome/Objective: AppliedBiological Science Techniques in Practice| Understand Contextual Impact of Biotechnology

Review the content of required BIOT classes in relationship to BIOT programoutcomes

The overall goal of the Professional Program in Biotechnology is to produce graduateswho have a strong foundation developed through achievement of the outcomes, whichcan then be built upon to achieve the broader program objectives. The PPiB curriculumis designed to accomplish this goal as a result of the collective experiences andknowledge obtained by completing all of the courses required for the Master ofBiotechnology degree. The program prepares an annual report that includesdescriptions of the methods, assessment data, a report of the findings, and a list ofrecommended actions. As illustrated in Measures and Findings, most of the outcomesand objectives are achieved and meet/exceed expectations. In response to the resultsof each assessment cycle, we create recommendations to improve the PPiB program.Recommendations and Actions: The achievement of program objectives and outcomesmeets and exceeds our expected goals. No changes or recommendation are provided.But we have defined an action item for Continuous Improvement: we started to work oncreating a plan that would provide statements of where the outcomes are addressed inthe program curriculum, how their level of attainment would be assessed, and how theassessment results would be used to improve the program. As a result of analysis ofnew program outcomes and objectives, all required BIOT classes syllabi were revisedto include updated list of course outcomes and their relationship to BIOT programoutcomes. We plan to continue working on this plan.Established in Cycle: 2015-2016Implementation Status: PlannedPriority: High

Analysis Questions and Analysis Answers

Based on the analysis of your findings, what changes are you currently making toimprove your program? Identify the specific findings you analyzed and how they ledto your decision.

The overall goal of the Professional Program in Biotechnology is to produce graduates whohave a strong foundation developed through achievement of the outcomes, which can thenbe built upon to achieve the broader program objectives. The PPiB curriculum is designedto accomplish this goal as a result of the collective experiences and knowledge obtained bycompleting all of the courses required for the Master of Biotechnology degree. The

program prepares an annual report that includes descriptions of the methods, assessmentdata, a report of the findings, and a list of recommended actions. As illustrated in Measuresand Findings, most of the outcomes and objectives are achieved and meet/exceedexpectations. In response to the results of each assessment cycle, we createrecommendations to improve the PPiB program. Recommendations and Actions: Theachievement of program objectives and outcomes meets and exceeds our expected goals.No changes or recommendation are provided. But we have defined an action item forContinuous Improvement: we started to work on creating a plan that would providestatements of where the outcomes are addressed in the program curriculum, how theirlevel of attainment would be assessed, and how the assessment results would be used toimprove the program. As a result of analysis of new program outcomes and objectives, allrequired BIOT classes syllabi were revised to include updated list of course outcomes andtheir relationship to BIOT program outcomes. We plan to continue working on this plan.

Provideanupdateforcompletedorongoingac3onplansfromthepreviousyear(s).Highlightyourimprovements.

After a review of the findings of 2014-15 and 2015-2016 assessment cycle andrecommendations for the next cycle, PPiB continued to improve the program outcomesassessment plan. Action items for continuous improvement and closing the loop: (1) Wedeveloped a new assessment plan with new mission statement, objectives and outcomesfor the program. The current plan provides statements of where the outcomes areaddressed in the required BIOT curriculum, (2) Program outcomes were aligned witheducational practices, (4) BIOT program prepared outcome-based course outlines (acommon course syllabus for each course) for all required BIOT courses and the syllabi willbe updated regularly based on the assessment results, (5) BIOT faculty will review courseassessment data and thus continuously improve BIOT courses to meet program outcomes.

Annual Report Section Responses

Program Contributions The PPiB is is currently preparing a comprehensive self study document for our upcomingacademic program review in 2017. We are also working in parallel to complete the processof programmatic re-affiliation with the National Professional Science Master's' Association(NPSMA). These documents will be archived here upon completion.

Appendix D

Faculty Meeting Minutes

MinutesAnnualBiotechnologyFacultyMeeting

April15,2011

Facultymemberspresent(15):ZhengdongCheng,CraigCoates,ClareGill,TimHall,NancyIng,VictorUgaz,ColinYoung,ChristieSayes,GusCothran,LorenSkow,ClintMagill,PatHolman,MikeCriscitiello,RobertAlaniz,ChristianHilty.Staffpresent:MarianCothranThefacultymeetingwascalledtoorderbyProgramChairVictorUgazat1:45PM.

1. WelcomeofnewBIOTfaculty—Victorintroduced4newmembersthathavejoinedsinceApril2010:J.CreightonMiller(HORT),MikeCriscitiello(VTPB),PatHolman(VTPB),andDorisD’Souza,Univ.ofTennessee(adjunct).

2. StatusofProgramReviewandchangeinhomedepartment—Victorannouncedthatwearestillwaitingonadatetoconcludetheprogramreview.VictorindicatedthatAlanSamsstillwouldlikeustoformatransitioncommitteetokeeptheaffectedpartiesinformed.ChristieSayesremarkedthatwecouldusetheprocessotherIDPsusewhenprogramsaretransferredbetweendepartments.CraigCoatesofferedamotiontocopyallcorrespondenceonthetransitiontoDaveReedtokeepaffectedpartiesinformedratherthanformingatransitioncommittee.MotionwassecondedbyClareGillandapproved.ClareindicatedwecouldappointastudenttotheECinanexofficiocapacity,andthatbodycouldservethesamefunctionasatransitioncommitteewithinputfromanyremainingaffectedparties.

3. DiscussionofIDPbudgetprocess,newfeeproposalstatus,andnewBiotechnologyDiversityScholarships.VictorpresentedaPowerPointpresentation(seeattached)withrelevantinformationregardingournewoperatingbudgetandthenewprogramfeeproposalstatus.HeindicatedhewoulddistributetheformulausedindeterminingourFY2012budget(appendedtominutes).Victorindicatedthattheprogram’sRegents’FellowshipshavebeenreplacedbyanewBiotechnologyDiversityScholarship.Foreachofthenextthreeacademicyears,wehavereceivedtop-offfundsof$2000,whichtogetherwith$2000inprogramfunds,willallowustoofferrecruitmentscholarshipstofourdomesticstudentsfromunderrepresentedethnicgroups.ForFall2011,wehaveawardedsuchscholarshipstotwoHispanic/LatinoandtwoAsianapplicants.

4. Updateon2010BIOTgraduates,2011internships,andFall2011admits.VictorpresentedbasicdemographicinformationfromFall2010showinganincreaseindomesticstudentsfrom17%to44%fromFall2009.OuraverageGREandGPAscoresremainhigh.FallAdmissionisgoingwell.Wehave23acceptances;that,withanexpectedsummerattritionof25%,shouldgiveusourtargetclasssizeof16-18students.Wehaveacontinuedhighrateofemploymentinindustryfollowinggraduation.AnanalysisoftheBIOT685DirectedStudyexperienceshowstheinterdisciplinarynatureoffacultyparticipation(seeattachedPowerPoint).

5. NominationforExecutiveCommitteerepresentatives—MarianannouncedthatVickieBuengerhadacceptedthenominationforMaysrepresentativeandthatWensheLiu

hadacceptedanominationfortheSciencerepresentative;asyet,noonehadexpressedaninterestintheCOALSorat-largepositionsontheEC.ChristieSayesmadeamotiontore-adjustthecycleofrepresentativestokeeptheECbalancedbetweenexperiencedandnewprogramfaculty;specifically,theCOALSandat-largepositionwillservetworatherthanthreeyearsthiscycle.ClaireGillsecondedthemotion;motionapproved.LorenSkowindicatedhewouldrunfortheat-largeposition.

6. Otherbusiness—ColinYoungindicatedthattheprogramshouldbeginthesearchforaBIOT601instructorforthefallsemestertoallowtheinstructorpreparationtimeoverthesummer.VictoragreedthatwewillbegintheprocesstoidentifycandidatesandthathewouldaddresstheissuewithMikePishko.WemaybeabletotapintojointNCTMfundingforinstructors.Colinvoicedaconcernthatourprojectedclasssizeof16-18wastoolargeforeffectiveinstruction.CraigstatedthattheprogramcouldinvestigategettinghelpgradingwritingassignmentsfromtheCenterforTeachingExcellence.Claresuggestedthattheprogramutilizecurrentfunds,orseekfundingfor,a96-wellplatePCRmachineforusebyBIOT601students.

Therebeingnofurtherbusiness,amotiontoadjournwasmadebyNancyIngandsecondedbyVictor.Meetingadjournedat3PM.Respectfullysubmitted,MarianCothran,ProgramCoordinator

IDPAllocationFormula:NotethattheallocationcategorieslistedbelowareintendedonlytorepresentageneralbreakdownofthekindsofoperationalsupportmostIDPsrequire.Thereisflexibilitytomovefundsbetweencategoriesbasedonspecificneeds.Also,IhaveincludednumbersspecificforMSstudentswhereapplicablesincethePPiBisnotaPh.D.program.Basesupport:$15,000perprogramStaffsupport:(total#ofstudents)*$300+(#uniquefacultycommitteechairs)*$250Graduateenhancement:(totalWSCH)*$12Strategicsupport:(total#ofstudents)*$240+(numberofgraduates)*$400Themetricsabovearedeterminedbasedon3-yearaverages.ForthePPiB,thiscorrespondsto35totalstudents,16graduates,2096WSCH,and12uniquefacultychairs.Basedonthisformula,PPiBwillreceiveatotalallocationof$68,452forFY2012.


April11,2012

Facultymemberspresent(21):JudyBall,ZhengdongCheng,EleanoreConant,GusCothran,MikeCriscitiello,BarbaraGastel,ClareGill,TimHall,PatHolman,NancyIng,ClintMagill,ZivkoNikolov,SureshPillai,MikePishko,KeertiRathore,LorenSkow,DavidStelly,VictorUgaz,JaneWelsh,ColinYoung,HongbinZhang.Staffpresent:MarianCothranThefacultymeetingwascalledtoorderbyProgramChairVictorUgazat11:45AM.

1. Welcome&newBIOTfaculty—Victorintroduced8newmembersthathavejoinedsinceApril2011:GarryAdams,JamesCai,andVinceGresham(VetMed);MariaKingandMikePishko(Engineering);RajeshMirandaandMariappanMuthuchamy(TAMUHSC);andAlinaSorescu(Mays).TheprogramofficehasmovedtothenewNationalCenterforTherapeuticsManufacturing(NCTM).MikePishkoannouncedthattherewillbeanewbusstopatNCTMpriortothestartoffallsemesterclasses.

2. Admissions—Fall2012class,GraduateMeritFellowship,BiotechnologyDiversityScholarships,fallrecruitmentefforts&springprospectivestudentcampusvisit—Victorpresentedbasicdemographicsofthepasttwoyearsofstudents,statisticsonourFall2012admissionsefforts,andinformationonourenhancedrecruitingeffortsoverthepastyear(seeattachedPowerPointpresentation).DavidStellynotedthatthelossweexperienceofacceptedstudentsoverthesummeriscommontomanyprograms.ClareGillnotedthatstudentsshouldprovidediversitystatementsforourBiotechnologyDiversityScholarship.Theprogramwillcontinuetokeepabreastofon-goingcampus-wideinitiativestopromotediversity.SureshPillaivolunteeredtosendMarianarecruitingcontactforSt.Edward’sUniversity,andMikeCriscitielloencouragedtheprogramtoapplyforthe$500travelgrantstobringinprospectivestudentsforcampusvisits.

3. Programbudget/feeapproval/externalreviewcompleted—VictorannouncedthatwedonotyethaveafinalprogrambudgetforFY13.OurrequestedprogramfeewasapprovedlastMaybytheBoardofRegents,andourprogramreviewwascompletedlastNovember.

4. Updateon2011BIOTgraduates,2011internships,and2012internships—Programgraduatesarecontinuingtofindjobsandinternships.Abouthalfoftheinternshipsin2011werewithindustry(seeattachedpresentationslidesfordetails).

5. Newinitiatives:• Curriculum—BIOT602,BIOT685,BIOT684—Victorhighlightedtheteam-

taughtBIOT602format(nowanelectivecourseinthecurriculum),theprojectestablishmentformnowusedforBIOT685andthediversefacultyparticipationinthiscourse,andtheprogramrequesttoallowstudentstorepeatBIOT684once.FacultyhadseveralsuggestionsfortheBIOT602course.MikeC.suggesteditcouldbetakenlikeJaneWelsh’smodularimmunologycourse,Sureshsuggesteditcouldbeofferedinamini-mester,andJudyBalladvocated

addingmoreblocksandgivingstudentsachoice.ZivkoNikolovsuggestedreferringtheseideastotheprogramcurriculumcommitteeforconsideration.ClaresuggestedthattheprogramconsiderassigningfacultymemberstoserveasprofessionalmentorsthatcouldhelpstudentslocatefacultyfortheBIOT685directedstudy,improveresumes,andhelpfindcommitteemembers.ColinYoungnotedtheimportanceofusingkeywordsinresumes.TheECwillconsidertheimplementationofamentoringprogramfornewBIOTstudents.

• Programblog/partnershipwithScience&TechnologyJournalismProgram—TheprogramhopestocontinuethebloginthefallwithhelpfromanotherSCTJstudentandwilladdresstechnicalproblemsrelatingtothesubscriptionprocess.WemayemployConstantContact,forinstance,tomanageemail.

• OutstandingGraduateandOutstandingFirstYearAwards—theseawardsarepresentedatourfallandspringstudentdevelopmentconferenceheldincollaborationwithourIndustryAdvisoryCouncil.

• Fall&SpringAdvisoryCouncilStudentDevelopmentConferences—Facultyareencouragedtoattendtheafternoonsessionswhichfeaturetheinternshippresentationsofprospectivegraduates.

6. Newindustrypartnerships—VictorannouncedthatwehavenewAdvisoryCouncilmembersrepresentingBaxterBioscience,CarisLifeSciences,Allergan,andKalonBiotherapeutics.MarianhasbeenworkingwiththenewInstituteforAppliedCancerScienceatMDAndersontohireourstudentsasinterns.SureshsuggestedtheprogramconsidersubscribingtoLinkedInProfessionaltofacilitatethestudentinternshipsearch.

7. NominationsforExecutiveCommitteerepresentatives—JudyBallandJoeSturinoarenomineesfortheAt-largerepresentativetotheEC;VictorUgazisthenomineefortheCollegeofEngineeringposition.NofurthernominationsweremadefromthefloorfortheECrepresentatives.On-lineballotswillbesenttofacultypriortoMay1st.

8. Amendmenttobylaws—VictorpresentedaproposedrevisiontotheECelectionprocedurecraftedbytheECattheirSept.,2011meeting.ClaresuggestedexploringadifferentelectionprocedurefollowingbytheGeneticsIDP.VictoragreedtocraftasecondoptionbasedonGeneticsandsendtotheECforconsideration.

9. Otheritems—Therewasadiscussionregardingwhethertheprogramshouldcontinuethepresentfinalexamformatandcommittee.Marianagreedtolookatotherprofessionalprogramsoncampus,seewhattheyweredoing,andreportbacktotheEC.

Therebeingnofurtherbusiness,themeetingadjournedat1:15PM.Respectfullysubmitted,MarianCothran,ProgramCoordinator


April3,2013

Facultymemberspresent(16):SakhilaBanu,LucBerghman,JamesCai,GusCothran,MikeCriscitiello,PaulDefigueiredo,BarbaraGastel,ClareGill,IvanIvanov,NurulIslam-Faridi,MariaKing,ZivkoNikolov,KeertiRathore,VictorUgaz,ColinYoung,HongbinZhang.Staffpresent:MarianCothranThefacultymeetingwascalledtoorderbyProgramChairVictorUgazat11:40AM.

1. Welcome&newBIOTfaculty—Victorintroduced4newmembersthathavejoinedsinceApril2012:SakhilaBanu,IvanIvanov,andWaithakaMwangi(VetMed);andDickLester(Mays).

2. Admissions—Fall2013class,GraduateRecruitmentScholarships,fallrecruitmentefforts&springprospectivestudentcampusvisit—Victorpresentedbasicdemographicsofthepastthreeyearsofstudents,statisticsonourFall2013admissionsefforts,andinformationonourenhancedrecruitingeffortsoverthepastyear(seeattachedPowerPointpresentation).Anincreaseinfemaleenrollmentintheprogramwasnoted,andMarianaddedthatwehavemadeadmissionoffersforFall2013toslightlymorefemales(22of39offersor56%).MikequestionedifwehadadirectivetoincreasetheadmissionofdomesticstudentsandMarianstatedthatitisaprogramgoal,buttheadministrationhasnotadvocatedthisforourprogram.VictornotedthatthepercentofinternationalstudentsinourprogrammirrorsthatoftheCOEandperhapstheCollegeofScience.

3. Programbudget—VictorannouncedthatourFY14IDPallocationhasincreasedfrom$64,184inFY13to$67,496andthatwearebenefittingfromasupportmetricbasedinpartonthenumberofuniquefacultychairsandco-chairs,whichincreasedthisyearintheBIOTIDP.

4. Updateon2012BIOTgraduates,2012internships,and2013internships—Programgraduatesarecontinuingtofindjobsandinternships.About60%oftheinternshipsin2012werewithindustry(seeattachedpresentationslidesfordetails).Marianreportedthat2013internshipoffersarecomingearlierthisyear.

5. Newinitiatives:• Fall&SpringAdvisoryCouncilStudentDevelopmentConferences—weofferedour

SpringAdvisoryCouncilStudentDevelopmentConferenceinFebruary.Thechangeintimingwastoenhancenet-workingforinternshipsandjobsearlierinthesemester.

• Studentpresentations&awards—AnearlierAdvisoryCouncilDevelopmentConferencedoesnotallowforstudentpresentationsorawards,whichwillbeataseparateeventApril19th(facultyinvitedtoattend).

• BiomedSA—InanefforttopromotetheBIOTprogramwithintheSanAntoniobiomedicalcommunity,VictorandMarianmetwithAnnStevensthePresidentof

BiomedSAlastsummer.Ms.StevenspresentedaBrownBagseminartoBIOTstudentsinFeb.andhasbeensupportiveofourprogram.

• ProgramBlog/partnershipwithScience&TechnologyJournalismProgram—Thisspringwehavemovedfromusinginterns/gradassistantsintheScience&TechnologyJournalismprogramtousinginterestedBIOTstudentsaseditors.Thisallowsourstudentstoacquirenewskillsrelatedtoonlinemedia.Theblogisnowhasamonthlyproductionschedule.

• BIOT602Experiential,high-impactcurriculum—Wearecontinuingwiththeteam-taught,modularapproachadoptedforBIOT602lastspring(seePowerPointattachmentfordetails).Mikeremarkedthatanewmoduleinbioinformaticscouldbeattractivetostudents.ClarewonderedifwecouldexpandtotwosectionsofBIOT602toaccommodateadditionalmodules.Colinvolunteeredtoteachamoduleinvaccineproduction,andMikesaidhewouldemailBIOTfacultytoassessinterestinteachingothermodules.

• Opportunitiesto“shadow”industryprofessionals—MarianaskedforfeedbackregardingthisideaasanadditionalprofessionaldevelopmentoptionforourBIOTstudents.Clarefeltaweekofshadowingmightbenecessaryforstudentstounderstandindustryjobs.

• IncreasingaccessibilitytoTAMUundergraduates—VictormentionedthatitmaybeworthwhiletoconsiderwaysforundergraduateseniorsatTAMUtobegintakingcoursesthatwouldpreparethemtoentertheBIOTprogram.

• Whatisthe“right”sizeoftheprogram?—ColinnotedthatGov.Perryhadindicated7200jobswillresultfromtherecentlycreatedCenterforInnovationinAdvancedDevelopmentandManufacturinginCollegeStation.Paulpointedoutthatitwouldbeimportanttoconsiderthebalancebetween“local”/externalinternshipsand/orjobplacementinmakingdecisionsaboutgrowth.

6. NominationsforExecutiveCommitteerepresentatives—LucBerghmanisthenomineefortheCollegeofAgricultureandLifeSciencesposition,andMikeCriscitielloisthenomineefortheCollegeofVeterinaryMedicineandBiomedicalSciences.Wearestillinneedofapersontoserveintheat-largepositionbeingvacatedbyLorenSkow.NofurthernominationsweremadefromthefloorfortheECrepresentatives.On-lineballotswillbesenttofacultypriortoMay1st.

Therebeingnofurtherbusiness,themeetingadjournedat1:10PM.Respectfullysubmitted,MarianCothran,ProgramCoordinator

Minutes

BIOT faculty meeting

October 6, 2014

Faculty members present: Drs. Nurul Faridi, Maria King, Carol Loopstra, Jane Welsh, Michael Criscitiello, Colin Young, Karen Wooley, Gus Cothran, Wenshe Liu, Clare Gill, Victor Ugaz, Tim Hall.

Program coordinator: Dr. Larissa Pchenitchnaia

The faculty meeting was called to order by Program Chair Dr. Victor Ugaz at 11:30am.

1. Welcome and Introductions. Twelve BIOT faculty were present at the meeting. Dr. Ugaz introduced a new program coordinator Dr. Larissa Pchenitchnaia.

2. Admissions Update. Dr. Ugaz presented basic statistics for Fall 14 admissions, including # of complete applications, admitted students’ GREs, GPAs, and demographics. Additionally, Dr. Ugaz provided basic statistics of BIOT students of past 4 years, specifically comparing the numbers of domestics and international students. An increase in domestic students was noted, 53% of new Fall 14 students are domestic (10 out of 19 students). Please see attached powerpoint. A short discussion followed: there was a suggestion to provide admitted students’ undergraduate majors; discussed why students who accepted offers did not come to classes (visa, business/money issues, accepted other offers).

3. Program highlights. BIOT department has completed a task of creating a new website. Dr. Ugaz talked about new approaches for organizing Advisory Council and Student Development Conferences. New Student development Conference in November 2014 will take place in Houston, Coca Cola North America Office and will also include a field trip to a biotechnology company. In 2013 Biotechnology society received funding through College of Engineering to support student travel and biotechnology society activities. Program graduates are continuing to find jobs and internships. 2013-2014 graduate profiles were discussed: all BIOT graduates were employed after graduation (100%). Several faculty members asked about the relation between internships/full-time employments. Dr. Ugaz confirmed that several students were hired by the internship companies. However it was also noted that students may experience a smoother pathway to progress toward full-time employment at the internship site if the work term occurs during their final semester. It was noted that there is a strong increase in local biotech industry demand. All BIOT students completed internships during summer 13. It was suggested to include the business/research sector of companies in the listing of internship and job placement data. The issue of part-time employment for international students was also discussed in light of increasing local opportunities, and it was suggested that employers be informed about the need for the

employment experience to be tied to CPT. A “scholarship” mechanism was suggested to enable employers to support the students and help offset the additional tuition burden. There is a strong faculty involvement in BIOT students’ faculty committees. Fifteen unique committee chairs representing all TAMU Colleges serve current 20 students (2nd year students). New Fall 2014 students have already started organizing faculty committees as well.

4. New Business. Dr. Ugaz reported that he continues to receive new faculty requests to join the program. It was recommended to request some kind of a brief report from current BIOT faculty regarding their involvement in the program (every 3 years). Current students ask for more involvement of business faculty. The program currently allows business faculty who are not currently BIOT faculty to serve as committee members (not chairs). Faculty discussed the availability of bioethics classes at TAMU. Additionally, it was mentioned that BIOT program has one “fast track” student this year/from undergrads to masters. Several faculty expressed their interest in continuing BIOT 602. An idea to have a mini-symposium after students complete BIOT 685 and/or BIOT 602 was discussed. The meeting adjourned at 1:00pm.

1

Program Overview

October 16, 2015

http://ppib.tamu.edu

Fall 2015 Admissions

• 63 complete applications (includes 2 change of major) (90 in 2014, 69 in 2013, 67 in 2012, 74 in 2011)

• 47 offers, 29 accept, 19 arrive for class– 2014: 28 accept, 19 arrive for class– 2013: 28 accept, 19 arrive for class– 2012: 30 accept, 3 defer, 21 arrive for class– 2011: 26 accept, 17 arrive for class– 2010: 23 accept, 17 arrive for class

• 11 scholarships ($1,000 each)• Thanks to admissions committee!

– Luc Bergman, Agriculture– Mike Chriscitello, CVM– Clint Magill, COALS– Rajesh Miranda, TAMU HSC– Victor Ugaz, Engineering

Fall 2015 class:Domestic students

GPA GREQ+V GREV GREQ GREW TOEFL ETHNICITY GENDER COUNTRY MAJOR UNIVERSITY3.3 321 160 161 3.5 W M USA FoodSciences TexasA&MUniversity2.9 320 163 157 4.5 W M USA BME NorthwesternUniversity2.63 313 157 156 4.5 W F USA/livesinTX Zoology OregonStateUniversity2.86 308 144 164 3 Oceanic M GreenCard BiochemistryandMol. PennStateUnivesrity3.4 291 146 145 4.5 H F USA ForensicScience TexasA&MUniversity3.5 284 140 144 4 W F USA/livesinTX AnimalScience KansasStateUniversity2.77 311 157 154 3.5 Hawai/W F USA BIOT UniversityofHouston

Fall 2015 class:International students

GPA GREQ+V GREV GREQ GREW TOEFL GENDER COUNTRY MAJOR UNIVERSITY3.2 329 159 170 4.5 110 M India BIOT PanjabUniversity3.04 323 161 162 4.5 118 F India/Singapore BENG/Chem Eng NationalUniversityofSingapore3.32 317 157 160 4 113 F India BIOT VelloreInstituteofTechnology3.64 313 149 164 2 86 F China Biology ChangdongAgriculturalUniversity3.35 309 148 161 3.5 104 F India Btech inPharmaceut InstituteofChemicalTechnology3.51 308 147 161 3 85 M Taiwan Nutrition ChinaMedicalUniversity

3.85 301 152 149 4 108 F India MBBSMedicineSriRamachandra Medcal CollegeandRSRCH

Inst.3.43 301 144 157 3 93 M India BIOT ThadomalShananiEngineeringcollege3.33 300 146 154 3 90 F India BIOT PanjabUniversity3.5 300 149 151 4.5 F India/Canadacitizen BIOT DYPatilInstituteBiotech&Bioinformatics3.09 304 149 155 3.5 113 F India3.84 318 152 166 3 90 M Taiwan NationalTaiwanUniversity

Fall 2015 class:Metrics

• Overall GPA 3.3• USA Students GPA 3.1• INT Students GPA 3.4

• Overall GRE Q+V 309• USA Students Q+V 307• INT Students Q+V 309• TOEFL: 101

• Overall GRE V 152• USA Students V 152• INT Students V 151

• Overall GRE Q 157• USA Students Q 154• INT Students Q 159

• 7 domestic / 12 international (37%)• 12 female (63%)

Fall 2014 Admissions

• Actual fall 2014 incoming class (19 students)

GPA GREV GREQ GREW TOEFL

3.44 148 152 33.16 157 155 43.30 155 152 43.07 155 153 43.25 152 146 42.73 157 153 3.53.34 160 150 42.49 156 155 42.93 145 148 3.53.57 146 166 33.68 155 155 4.5 1083.7 151 159 4 1073.37 150 162 3 963.13 149 153 4 1013.62 150 156 3 1023.81 148 159 3 983.96 153 159 3 1163.83 147 156 4.5 1093.89 148 158 3 102

MEANS 3.38 151.7 155.1 3.63 104.3

Fall 2014• 10/19 domestic

(53%)

• Demographics– 11 male, 8 female– International profile:

8 India1 China

– Domestic profile:8 caucasian, 1 oceanic,1 black

2

Student Profile


(44%)– 17% in Fall 2009

• Demographics– 13 male, 12 female– 1 hispanic,

6 caucasian, 18 asian


(38%)


4 caucasian, 25 asian

Metric Fall 2015 Fall 2014 Fall 2013 Fall 2012 Fall 2011 Fall 2010 Fall 2009median/average GRE 309 307 310 1245 1242 1250 1260average GPA 3.29 3.38 3.43 3.48 3.56 3.56 3.44average TOEFL 101 104 106 101 106TOEFL range 85-118 96-116 92-115 85-115 98-117


(37%)


9 caucasian, 25 asian,1 black


(39%)


13 caucasian, 22 asian,3 black

Professional Development Highlights

Advisory board meeting Coca-Cola North America

(Houston office)

Professional Development Highlights

Field trips: CelltexTherapeutics (Houston),

Caliber (B/CS)

1st Annual PPiBResearch Symposium

1st Annual PPiBResearch Symposium

1.! Using(Gas(Chromatography/Mass(Spectrometry/Olfactometry(to(Determine(Aroma(and(Flavor(Profiles(of(Food(Products((

2.! Technology(Commercialization:(SolarAgs(Mobile(App(3.! Effects(of(gestational(exposure(to(chromium(VI(on(the(fetal(ovary(development(and(

reproductive(function(in(the(adult(F1(rats(4.! Determining(the(structure(and(function(of(previously(uncharacterized(proteins(in(

Mycobacterium-tuberculosis-(Mtb)(5.! Risk(Assessment(of(a(BSL3(Laboratory(Containment(Breach(6.! Nanoparticles(and(Bacterial(Contamination(in(Nuclear(Reactor(Cooling(Systems((7.! Market(Research(8.! Phage(based(Pesticides(and(Stroke(Therapy(Perlecan(Domain(V(9.! NR4A1(as(a(Potential(Drug(Target(for(Acute(Myeloid(Leukemia(10.!PCR(Master(Mix(Economization(11.!Geographical(Information(System(GIS):(SituMap:(Technology(Assessment(

Characterization(of(Metabolically(Active(yet(NonZCulturable((MAyNC)(Cells(12.!Aberrant(expression(disrupts(coordinated(gene(activation(and(repression(in(autistic(brains(13.!RevaTis(14.!Surface(Engineering(of(Lentiviral(Vectors(Using(Split(Inteins(

Recent Graduate Profiles

December14andMay15Graduates Company/PlaceAdjei,Kwabena AssociateScientist(QC) DPTLaboratories,SanAntonio,TXAgarwal,Vartika ClinicalResearchAssociate DAVAOncology,Dallas,TXBolaki,Menaka ResearchAssistant DepartmentofMedicine,BaylorCollegeofMedicine,HoustonDeng,JieSonal AssociateScientist MDAndersonCancerCenter,Houston,TXGopish,Ashwath VolunteerResearchAssistant SanFrancisco,CALee,Bryan DoctorofPharmacyStudent UniversityofHouston,Houston,TXLee,Hsiao-Ju ResearchAssistant AcademyBiomedical,Houston,TXMarwah,PulkitNambiar,Aishwarya ValidationAnalyst ValidationAssociates,LLC,Herndon,VA

Ogun,Oluwadara ResearchAssociateMicrobialPathogenesis&Immunology,TexasA&MHealthScienceCenter,TexasA&MUniversity,CollegeStation,TX

Ramirez,Roxanne ResearchAssistantUnitedStatesDepartmentofAgriculture,USDA,AgriculturalResearchService,CollegeStation,TX

Reyes,IsmaelSalem,Nihal PhDStudent TexasA&MUniversity,TexasA&MHealthScienceCenter,InstituteforNeuroscienceSharooni,Sara Nashville,TN

Shaukat,Umer ProjectCoordinatorOfficeofTechnologyTranslation,HealthScienceCenter,TexasA&MUniversity,CollegeStation,TX

Sullvan,Young ClinicalMonitoringAssociateI PAREXEL,Raleigh-Durham,NorthCarolinaVijaukumar,Deepa BentonHarbor,MI

Yu,Hangjin AgriculturalResearchTechnicianI TexasA&MAgrilife ResearchandExtensionCenter,Amarillo,TX

3

Recent Graduate Profiles

December13andMay14GraduatesName Title/Position Company/Place

Abbas,Kamran ProcessDevelopmentAssociate Lonza,Houston,TXAlmario,Priscila LabTechnician InGeneron,Houston,TX

Bourgis,Alexandra ProgramAnalystTexasA&MHealthScienceCenter/PublicHealthPreparednessandResponseDepartment,CollegeStation,TX

Das,ShubhagataAssociateManager-ScientificAffairs LuminexCorporation,Austin,TX

Dev,Unnati ProductSpecialist LICORBiosciences,Lincoln,NEFriedman,Matthew ProjectManagementIntern AjinomotoAlthea,Inc.,SanDiego,CA

Gupta,Mehak ResearchAssistantMicrobialandPathogenesisandImmunologyLab,TexasA&MUniversity,CollegeStation,TX

Gupta,Sakshi ValidationEngineer ValidationAssociates,Herndon,VAHamblen,Geddy Microbiologist Ecolyse,CollegeStation,TXHarrison,Caitlin QualityControlAnalyst KalonBiotherapeutics,CollegeStation,TXKanade,Cauvery MediaPrepTechII KalonBiotherapeutics,CollegeStation,TX

Ligons,PeriDownstreamManufacturingTechII KalonBiotherapeutics,CollegeStation,TX

Niphadkar,Utkarsha CommercializationAsociate NewOrleansBioInnovationCenter,NewOrleans,LANowacki,Lauren AssociateSalesConsultant KapaBiosystems,Houston,TX

Ramchandani,KiranDownstreamManufacturingTechII KalonBiotherapeutics,CollegeStation,TX

Sangewar,Neha TechnicianIDepartmentofVeterinaryPathobiology,TexasA&MUniversity,CollegeStation,TX

Shetty,RashmiDownstreamManufacturingTechII KalonBiotherapeutics,CollegeStation,TX

Vorpahl,Amanda ResearchAssistant TexasA&MHealthScienceCenter,CollegeStation,TXWood,Alexander ProgramCoordinator NationalCenterforTherapeuticsManufacturing,CollegeStation,TX

Yang,Jizhou PhDStudentCollegeofVeterinaryMedicineandBiomedicalSciences,TexasA&MUniversity,CollegeStation,TX

Summer 2015 Internships

Cobb,Christine DepartmentofAnimalScience,TexasA&MUniversity CollegeStation,TX

Conrad,Jared OfficeofTechnologyCommercialization,TexasA&MUniversity CollegeStation,TX

Adams,Keaton KGlobalFibers Bryan,TX

Wood,Elikem Spring2016

Rapp,Janae MDAndersonCancerResearchCenter Houston,TX

Rios,Donna OfficeofSafetyandSecurity,TexasA&MUniversity CollegeStation,TX

Kinight,Brighid

Mueller,Michael Ugazgroup,ChemicalEngineeringDepartment,TexasA&MUniversity CollegeStation,TX

Chapman,Mary SRC,Inc NorthSyracuse,NY

Karki,keshav DepartmentofVeterinaryPhysiology,TexasA&MUniversity CollegeStation,TX

Abichandani,Yogesh NewOrleansBioInnovationCenter NewOrleans,LA

Pasaya,Fareen Novavax,Inc. Gaithersburg,MD

Ouyang,Qianwen DepartmentofVeterianaryIntegrativeBiosciences,TexasA&MUniversity CollegeStation,TX

More,Saanika OfficeofTechnologyCommercialization,TexasA&MUniversity CollegeStation,TX

Ugamraj,Harshad AppliedBiosensors SaltLakeCity,UT

Reddy,Prahelika TexasA&MHealthScienceCenter,IBT/CIID&AffymetrixHouston,TX/Cleveland,OH

Dave,Gipshu Zoetis Durham,NorthCarolina

Khan,Mahwish OfficeofTechnologyTransfer,TAMUHealthScienceCenter CollegeStation,TX

Guntamudugu,Bharath OfficeofTechnologyTransfer,TAMUHealthScienceCenter CollegeStation,TX

BIOT Committee ChairsFall 2014 Cohort

Student CommitteeChairCobb,Christine Dr.GillConrad,Jared Dr.LesterAdams,Keaton Dr.GentryWood,Elikem Dr.BanuRapp,Janae Dr.SacchettiniRios,Donna Dr.CriscitielloKinight,Brighid Dr.RathoreMueller,Michael Dr.UgazChapman,Mary Dr.JohnsonKarki,keshav Dr.SafeAbichandani,Yogesh Dr.KaoPasaya,Fareen Dr.StellyOuyang,Qianwen Dr.Tiffany-CastiglioniMore,Saanika Dr.UgazUgamraj,Harshad Dr.PillaiReddy,Prahelika Dr.CaiDave,Gipshu Dr.MirandaKhan,Mahwish Dr.WelshGuntamudugu,Bharath Dr.Ball

BIOT Committee ChairsFall 2015 Cohort

Student CommitteeChairBalakavi,NagaSaiL. NgBansal,Ishita WelshBufford,JosephD.Gallegos,Isabell CoatesKhasnavis,Nithisha Fuchs-YoungLee,Yi-TsangLin,Kuan-Yu MirandaLuster,Michelle DerrPatel,RiddhiHPatil,Ketki MwangiPutta,MeghanaRohra,RohitK.Sanghavi,SrushtiSidhu,Karatatiwant JohnsonStull,MatthewWang,Xiyuan Tiffany-CastiglioniWellman,Catherine KaoWhite,HaleyD. GillYang,Chieh-An

Advisory Council

Chris Burnett

Life TechnologiesAustin, TX

John Ferreira

Private Consultant, Bryan TX

Tyson Fetzer

Baxter BioscienceThousand Oaks, CA

Jose Carlos Garcia-Garcia, Ph.D.Proctor & GambleCincinnati, OH

Michaela Hoffmeyer

Luminex Corp.Austin, TX

Gary Krishnan, Ph.D.

Lilly Research LaboratoriesIndianapolis, IN

Wendy Maduff, Ph.D.

SubwayMilford, CT

Susan Magdaleno, Ph.D.

Life TechnologiesAustin, TX

Mukesh Maheshwari

Caris Life SciencesPhoenix, Arizona

Madison Mauze

Celltex Therapeutics CorporationHouston, TX

Deepthi MikkiliAllergan, Inc.Irvine, CA

Dalal Murgai

Regulatory Outsource Consulting, Inc.The Woodlands, TX

Tim Novak

Sigma-AldrichHouston, TX

Gunjot Rana

Luminex Corp.Austin, TX

Bill Reed, Ph.D.

Kalon BiotherapeuticsCollege Station, TX

Christie Sayes, Ph.D.

RTI InternationalResearch Triangle Park, NC

Barbara Thomas Smith

Barbara Thomas Smith, LLCThe Woodlands, TX

Cody L. Wilson, Ph.D.

The Coca-Cola CompanyAtlanta, GA

Ty K. Witten, Ph.D.

Monsanto CompanySt. Louis, MO

Issues for discussion

• Strategic vision/goals

• Program visibility/marketing

• Advisory board

• Curriculum

• Program leadership

Appendix E

PPiB Bylaws

1

BYLAWS

FACULTY OF BIOTECHNOLOGY

TEXAS A&M UNIVERSITY

ARTICLE I: DESCRIPTION 1

ARTICLE II: PURPOSE AND INTENT 1

ARTICLE III: MEMBERSHIP 1

ARTICLE IV: EXECUTIVE COMMITTEE 3

ARTICLE V: ELECTION OF THE EXECUTIVE COMMITTEE 3

ARTICLE VI: FUNCTIONS OF THE EXECUTIVE COMMITTEE 4

ARTICLE VII: FUNCTIONS OF THE OFFICERS 4

ARTICLE VIII: MEETINGS 5

ARTICLE IX: STANDING COMMITTEES 6

ARTICLE X: AMENDMENTS 7

REVISION HISTORY 7

1

Article I: Description

The Faculty of Biotechnology of Texas A&M University is an interdisciplinary faculty composed of members from various departments in several colleges.

Article II: Purpose and Intent

The principal function of the Faculty of Biotechnology is administration of the graduate program leading to the Master of Biotechnology, in conformance with the rules of the Office of Graduate Studies at Texas A&M University. The organization also serves to promote and facilitate communication among students and industry and to foster the development of biotechnology at Texas A&M University and other components of the Texas A&M University System. It arranges for periodic assembly of industry representatives, students and faculty and provides a forum for them and for others with interests in biotechnology. Its overall goal is the development and maintenance of a graduate program that is responsive to the students and the needs of the biotechnology industry in the State of Texas and the Nation.

Article III: Membership

1. Admissibility to the Faculty shall be determined by the Executive Committee in consultation with the Head of the faculty member’s administrative department.

2. Only permanent appointments to the Graduate Faculty of Texas A&M University with significant academic or service activities in the biological, industrial, business or liberal arts aspects of biotechnology are eligible to be members of the Faculty of Biotechnology. Active involvement in both academic and service programs of the Faculty of Biotechnology, such as described below is required to maintain membership.

a. Academic activities

1) Teaching in a lecture, seminar or laboratory Biotechnology course or other courses, both required and electives offered to students in the Masters of Biotechnology program.

2

2) Serve as an instructor for BIOT 685 students.

3) Direction of student seminar programs, BIOT 681.

4) Direct a student internship, BIOT 684.

5) Serve as the chair or member of a graduate committee of one or more biotechnology students.

b. Service activities

1) Participation in standing or ad hoc committees.

2) Attendance at meetings with the Industry Advisory Council.

3) Attendance at the Biotechnology Faculty Annual Meeting.

4) Serve as PI for a Grant/Award that supports Biotechnology Program Activities, for example a training grant, conference grant, or REU grant.

5) Participate in independent recruiting activities such as handing out Biotechnology Program recruiting materials to potential student recruits at conferences or seminar presentations at other academic institutions.

6) Participate in development activities for the Biotechnology Program.

3. Permanent appointments to the Faculty of Biotechnology are eligible to:

a. Teach graduate Biotechnology courses

b. Serve on the TAMU Faculty of Biotechnology Executive Committee

c. Vote on matters requiring a vote of the Faculty of Biotechnology

d. Serve on the Faculty of Biotechnology Membership Committee

e. Chair standing or ad hoc committees of the Faculty of Biotechnology

4. Membership in the Faculty of Biotechnology will be reviewed every 3 years. To maintain membership, faculty must be actively involved in both the academic and service programs of the Faculty of Biotechnology.

3

Article IV: Executive Committee

1. The Executive Committee shall consist of seven elected Members of the Faculty of Biotechnology

2. The Executive Committee shall include one representative from each of the five academic colleges that participate in the Biotechnology Program. These representatives shall be elected by the Members of the Faculty of Biotechnology of that academic college. The other members of the Executive Committee shall be elected at‐large by all the Members of the Faculty of Biotechnology. Hiring and interviewing of program staff will be overseen by the executive committee.

3. Members of the Executive Committee shall serve for three years. Their service will begin on June 1 of the year elected, and the terms shall be staggered.

4. The Executive Committee members shall nominate from among its members a chair and a vice‐chair. These positions shall be elected by majority vote of the Executive Committee members for three year terms. The three‐year terms of the chair and vice‐chair appointments supersede the previous terms of election to the Executive Committee. The chair and vice‐chair elections, when needed upon expiration of their respective terms, shall take place following the annual election of new Executive Committee members by the faculty.

5. The Executive Committee shall fill any vacancies that may occur in its members or offices between the annual elections.

Article V: Election of the Executive Committee

1. Any member of the Biotechnology faculty seeking a place on the Executive Committee shall self‐nominate or agree to nomination by another for the appropriate academic faculty or at‐large position open. All nominations shall be in writing and submitted to the Biotechnology Faculty Chair.

2. The nomination period for election of Executive Committee members shall be a two‐week period prior to the annual faculty meeting. Further nominations may be made from the floor at the annual meeting of the Faculty of Biotechnology.

3. Elections shall be conducted by e‐mail ballot to be distributed to Members after the annual Faculty of Biotechnology meeting on or before May 1 of each calendar year. Each Member shall vote for no more candidates than the number of positions to be filled. Those persons receiving the most votes will be declared elected. Election results shall be e‐mailed to the members promptly. Elected members shall assume their duties on June 1 of the calendar year.

4

Article VI: Functions of the Executive Committee

1. The principal functions of the Executive Committee shall be to:

a. Determine and implement policy for the good of the Faculty of Biotechnology and represent the interests of the faculty generally to various University committees and other agencies.

b. Review courses and programs in biotechnology with the faculty and make recommendations for changes and new courses as appropriate, with the aim of insuring uniform excellence in the Texas A&M University Biotechnology Program.

c. Receive and rule on the acceptability of applicants for graduate study in biotechnology.

d. Receive and rule on the admissibility of nominations for membership in the Faculty of Biotechnology.

e. Develop the budget for teaching functions in Biotechnology.

f. Coordinate efforts to expand interactions with industry partners and oversee development activities.

g. Conduct all additional business deemed necessary for the proper functioning of the Faculty.

2. Technical administrative procedures pertaining to graduate degree programs shall be handled through the program office. Other matters shall be administered by the Executive Committee.

Article VII: Functions of the Officers

1. Chair

The chair is the chief officer and representative of the Executive Committee and the Faculty of Biotechnology. The chair’s primary responsibility is the execution of those administrative functions that are delegated to the Faculty of Biotechnology. The chair shall:

a. Chair the Executive Committee of the Faculty of Biotechnology.

5

b. Provide leadership in short‐ and long‐term planning for the program and represent that faculty group in College and University meetings, as appropriate.

c. Coordinate recruitment of graduate students into the graduate program in the discipline.

d. Approve admission of biotechnology graduate students for the Biotechnology Faculty.

e. Recommend the budget and approve expenditures for teaching functions in Biotechnology.

f. Appoint, with approval of the Executive Committee, the chair and other members of standing committees and special committees.

g. Direct graduate student advising.

h. Coordinate periodic program assessment consistent with institutional guidelines.

i. Ensure that teaching evaluations are conducted for all Biotechnology courses.

2. Vice‐chair

The vice‐chair shall serve as chief officer of the Faculty of Biotechnology in the absence of the chair or when designated by the chair.

Article VIII: Meetings

1. The annual meeting of the Faculty of Biotechnology shall be held during the first two weeks of the month of April each year.

2. Special meetings of the Faculty of Biotechnology may be held at the call of the chair or by written application to the Executive Committee by five Members of the Faculty of Biotechnology.

3. A regular meeting of the Executive Committee shall be held each fall and spring semester. Other meetings of the Executive Committee may be held as frequently and for such purposes as are deemed desirable by the Executive Committee.

4. The minutes of each Faculty and Executive Committee meeting shall be distributed to all members of the Faculty of Biotechnology via e‐mail within 10 days after approval by the Executive Committee.

5. At Executive Committee and Faculty of Biotechnology meetings, Robert’s Rules of Order shall be followed in matters of parliamentary procedure.

6

6. A quorum for Executive Committee meetings shall consist of four members of the Committee. Twenty‐five percent of the Members shall constitute a quorum for meetings of the Faculty of Biotechnology.

Article IX: Standing Committees

The members of each standing committee shall be appointed prior to July 1 or each year and shall serve from July 1 through June 30 of the following year.

1. Committee on Curriculum and Educational Policy

The Committee on Curriculum and Educational Policy shall consist of three or more members. The principal functions of the committee shall be coordination of the graduate curriculum and review of teaching quality and effectiveness. The Committee shall also review and advise on newly proposed courses and programs in biotechnology and to periodically review existing graduate course offerings and programs in biotechnology.

2. Committee on Seminars

The Committee on Seminars shall consist of three members. It shall arrange for speakers and handle the necessary arrangements for the regular presentation of seminars on topics of interest.

3. Committee on Membership

The Committee on Membership shall consist of three or more Members. It shall screen applications for membership in the Faculty of Biotechnology and make a recommendation to the Executive Committee as to the acceptability of each applicant. The Committee on Membership shall also review the active status of all members on a three‐year basis.

4. Graduate Admissions Committee

The Graduate Admissions Committee shall consist of three or more members. It shall serve as an advisory committee to the Executive Committee by screening and evaluating the applications of prospective students for acceptance into the Biotechnology Program. The committee shall facilitate the processing of files acceptable candidates through departmental review and Office of Graduate Studies notification and shall monitor the progress and status of first year students.

6. Faculty and Student Awards Committee

The Faculty and Student Awards Committee shall be responsible for the nomination of faculty and students for local and national awards.

7

Article X: Amendments

Proposed amendments of the Bylaws shall be submitted to the Members of the Faculty of Biotechnology for approval or disapproval following either (1) approval of a motion to do so by majority vote of the Executive Committee or (2) written petition to the Executive Committee by a minimum of five Full Members of the Faculty of Biotechnology. Approval by two‐thirds or more of the Full Members voting in an e‐mail ballot is required to adopt amendments.

Revision History

Adopted: December 18, 2000

Amended: March 1, 2010

Amended: February 17, 2011

Amended: August 15, 2012

Appendix F

Institutional Profile

OFFICE OF THE PROVOST

Jack K. Williams Administration Building, Suite 100 1248 TAMU College Station, TX 77843-1248 USA Tel. +1 979.845.4016 Fax. +1 979.845.6994 http://provost.tamu.edu/

January 2, 2017 TO: External Program Reviewers and Program Accreditors FROM: Michael T. Stephenson

Associate Provost for Academic Affairs and SACSCOC Accreditation Liaison RE: Information required for USDOE Accrediting Bodies Texas A&M University is accredited by the Southern Association of Colleges and Schools Commission on Colleges to award baccalaureate, master's, and doctoral degrees. Consistent with comprehensive standard 3.13.1, the following provides the institution’s official position on its purpose, governance, programs, degrees, diplomas, certificates, personnel, finances, and constituencies and is published in official university documents as noted. Purpose

Classified by the Carnegie Foundation as a Research Doctoral University (Highest Research Activity), Texas A&M embraces its mission of the advancement of knowledge and human achievement in all its dimensions. The research mission is a key to advancing economic development in both public and private sectors. Integration of research with teaching prepares students to compete in a knowledge-based society and to continue developing their own creativity, learning, and skills beyond graduation.

The institution’s official mission statement, published both on the institution’s web page as well as in its annual university catalog, is:

Texas A&M University (Texas A&M) is dedicated to the discovery, development, communication and application of knowledge in a wide range of academic and professional fields. Its mission of providing the highest quality undergraduate and graduate programs is inseparable from its mission of developing new understandings through research and creativity. It prepares students to assume roles in leadership, responsibility and service to society. Texas A&M assumes as its historic trust the maintenance of freedom of inquiry and an intellectual environment nurturing the human mind and spirit. It welcomes and seeks to serve persons of all racial, ethnic and geographic groups, women and men alike, as it addresses the needs of an increasingly diverse population and a global economy. In the twenty-first century, Texas A&M University seeks to assume a place of preeminence among public universities while respecting its history and traditions.

Governance The governance of the institution was described in the 2012 certification of compliance submitted to SACSCOC.

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Texas A&M University at College Station, the flagship institution of the Texas A&M University System, has branch campuses located in Galveston, Texas and Doha, Qatar. A ten-member Board of Regents, appointed by the Governor, directs the Texas A&M System. The appointment of each Regent follows Texas Education Code (TEC, Chapter 85, Section 21).

TEC outlines the duties and responsibilities of the Board of Regents. These responsibilities are also defined in System Policy 02.01 Board of Regents and TEC 51.352. The Board elects two officers: Chair and Vice Chair. There are four standing committees: Audit, Academic & Student Affairs, Finance, and Buildings & Physical Plant. Special committees may be appointed by the Chair with Board approval.

At Texas A&M University the President is the chief executive officer; the President is not the presiding officer of the Board of Regents. The President reports to the state-appointed Board of Regents through the Chancellor of the Texas A&M University System. System Policy 2.05 Presidents of System Member Universities defines the duties of the President. The appointment of the President follows conditions set forth in System Policy 01.03 Appointing Power and Terms and Conditions of Employment, section 2.2. Personnel The institution is led by the President and members of his cabinet: Michael K. Young, President Karan L. Watson, Provost and Executive Vice President

Jerry R. Strawser, Executive Vice President for Finance and Administration and CFO Michael Benedik, Vice Provost M. Dee Childs, Vice President for Information Technology and CIO Michael G. O’Quinn, Vice President for Government Relations Dr. Douglas Palmer, Interim Vice President and COO, TAMU-Galveston Barbara A. Abercrombie, Vice President for HR & Organizational Effectiveness Jessica Rubie, Associate Vice President for Strategic Initiatives Christine Stanley, Vice President and Associate Provost for Diversity Amy B. Smith, Senior Vice President and Chief Marking & Communications Officer Glen A. Laine, Vice President for Research Carrie L. Byington, Senior Vice President TAMU Health Science Center, Dean of the

College of Medicine, and Vice Chancellor for Health Services Daniel J. Pugh, Sr., Vice President for Student Affairs Gen Joe E. Ramirez, Jr. Commandant, Corps of Cadets Amy B. Smith, Senior Vice President and Chief Marketing and Communications Officer Scott Woodward, Director of Athletics

Programs, Degrees, Diplomas, and Certificates

See the Institutional Summary submitted to SACSCOC

Finances See the Financial Profile 2016 submitted to SACSCOC

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Southern Association of Colleges and Schools

Commission on Colleges

INSTITUTIONAL SUMMARY FORM

PREPARED FOR COMMISSION REVIEWS

GENERAL INFORMATION Name of Institution Texas A&M University Name, Title, Phone number, and email address of Accreditation Liaison Michael T. Stephenson Associate Provost for Academic Affairs and SACSCOC Accreditation Liaison 979.845.4016 [email protected] Name, Title, Phone number, and email address of Technical Support person for the Compliance Certification Alicia M. Dorsey Assistant Provost for Institutional Effectiveness 979.862.2918 [email protected] IMPORTANT: Accreditation Activity (check one):

Submitted at the time of Reaffirmation Orientation Submitted with Compliance Certification for Reaffirmation Submitted with Materials for an On-Site Reaffirmation Review Submitted with Compliance Certification for Fifth-Year Interim Report Submitted with Compliance Certification for Initial Candidacy/Accreditation Review Submitted with Merger/Consolidations/Acquisitions Submitted with Application for Level Change

Submission date of this completed document: September 29, 2015

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EDUCATIONAL PROGRAMS 1. Level of offerings (Check all that apply)

Diploma or certificate program(s) requiring less than one year beyond Grade 12 Diploma or certificate program(s) of at least two but fewer than four years of work beyond

Grade 12 Associate degree program(s) requiring a minimum of 60 semester hours or the equivalent

designed for transfer to a baccalaureate institution Associate degree program(s) requiring a minimum of 60 semester hours or the equivalent

not designed for transfer Four or five-year baccalaureate degree program(s) requiring a minimum of 120 semester

hours or the equivalent Professional degree program(s) Master's degree program(s) Work beyond the master's level but not at the doctoral level (such as Specialist in

Education) Doctoral degree program(s) Other (Specify)

2. Types of Undergraduate Programs (Check all that apply)

Occupational certificate or diploma program(s) Occupational degree program(s) Two-year programs designed for transfer to a baccalaureate institution Liberal Arts and General Teacher Preparatory Professional

Other (Specify) GOVERNANCE CONTROL Check the appropriate governance control for the institution:

Private (check one) Independent, not-for-profit Name of corporation OR Name of religious affiliation and control: Independent, for-profit * If publicly traded, name of parent company:

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Public state * (check one) Not part of a state system, institution has own independent board Part of a state system, system board serves as governing board

Part of a state system, system board is super governing board, local governing board has delegated authority

Part of a state system, institution has own independent board * If an institution is part of a state system or a corporate structure, a description of the system operation must be submitted as part of the Compliance Certification for the decennial review. See Commission policy “Reaffirmation of Accreditation and Subsequent Reports” for additional direction.” INSTITUTIONAL INFORMATION FOR REVIEWERS Directions: Please address the following and attach the information to this form. 1. History and Characteristics Provide a brief history of the institution, a description of its current mission, an indication of its geographic service area, and a description of the composition of the student population. Include a description of any unusual or distinctive features of the institution and a description of the admissions policies (open, selective, etc.). If appropriate, indicate those institutions that are considered peers. Please limit this section to one-half page. 2. List of Degrees List all degrees currently offered (A. S., B.A., B.S., M.A., Ph.D., for examples) and the majors or concentrations within those degrees, as well as all certificates and diplomas. For each credential offered, indicate the number of graduates in the academic year previous to submitting this report. Indicate term dates. 3. Off-Campus Instructional Locations and Branch Campuses List all locations where 50% or more credit hours toward a degree, diploma, or certificate can be obtained primarily through traditional classroom instruction. Report those locations in accord with the Commission’s definitions and the directions as specified below. Off-campus instructional sites—a site located geographically apart from the main campus at which the institution offers 50 % or more of its credit hours for a diploma, certificate, or degree. This includes high schools where courses are offered as part of dual enrollment. For each site, provide the information below. The list should include only those sites reported and approved by SACSCOC. Listing unapproved sites below does not constitute reporting them to SACSCOC. In such cases when an institution has initiated an off-campus instructional site as described above without prior approval by SACSCOC, a prospectus for approval should be submitted immediately to SACSCOC.

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Name of Site Physical Address

(street, city, state, country) Do not include PO Boxes.

Date Approved by SACSCOC

Date Implemented by the institution

Educational programs offered (specific degrees, certificates, diplomas) with 50% or more credits hours offered at each site

Is the site currently active? (At any time during the past 5 years, have students been enrolled and courses offered? If not, indicate the date of most recent activity.)

Institutions with off-campus instructional sites at which the institution offers 25-49% credit hours for a diploma, certificate, or degree—including high schools where courses are offered as dual enrollment—are required to notify SACSCOC in advance of initiating the site. For each site, provide the information below. Name of Site (Indicate if site is currently active or inactive. If inactive, date of last course offerings and date of projected reopening

Physical Address (street, city, state, country) Do not include PO Boxes.

Date Notified SACSCOC by SACSCOC


Educational programs offered (specific degrees, certificates, diplomas) with 25-49% credit hours offered at each site


Branch campus—an instructional site located geographically apart and independent of the main campus of the institution. A location is independent of the main campus if the location is (1) permanent in nature, (2) offers courses in educational programs leading to a degree, certificate, or other recognized educational credential, (3) has its own faculty and administrative or supervisory organization, and (4) has its own budgetary and hiring authority. The list should include only those branch campuses reported and approved by SACSCOC. Listing unapproved branch campuses below does not constitute reporting them to SACSCOC. A prospectus for an unapproved branch campuses should be submitted immediately to SACSCOC. Name of Branch Campus




Educational programs (specific degrees, certificates, diplomas) with 50% or more credits hours offered at the branch campus

Is the campus currently active? (At any time during the past 5 years, have students been enrolled and courses offered? If not, indicate the date of most recent activity.)

4. Distance and Correspondence Education

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Provide an initial date of approval for your institution to offer distance education. Provide a list of credit-bearing educational programs (degrees, certificates, and diplomas) where 50% or more of the credit hours are delivered through distance education modes. For each educational program, indicate whether the program is delivered using synchronous or asynchronous technology, or both. For each educational program that uses distance education technology to deliver the program at a specific site (e.g., a synchronous program using interactive videoconferencing), indicate the program offered at each location where students receive the transmitted program. Please limit this description to one page, if possible. 5. Accreditation (1) List all agencies that currently accredit the institution and any of its programs and indicate the date of the last review by each. (2) If SACS Commission on Colleges is not your primary accreditor for access to USDOE Title IV funding, identify which accrediting agency serves that purpose. (3) List any USDOE recognized agency (national and programmatic) that has terminated the institution’s

accreditation (include the date, reason, and copy of the letter of termination) or list any agency from which the institution has voluntarily withdrawn (include copy of letter to agency from institution).

(4) Describe any sanctions applied or negative actions taken by any USDOE-recognized accrediting

agency (national, programmatic, SACSCOC) during the two years previous to the submission of this report. Include a copy of the letter from the USDOE to the institution.

6. Relationship to the U.S. Department of Education Indicate any limitations, suspensions, or termination by the U.S. Department of Education in regard to student financial aid or other financial aid programs during the previous three years. Report if on reimbursement or any other exceptional status in regard to federal or state financial aid.

Document History Adopted: September 2004

Revised: March 2011 Revised: January 2014

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1. History and Characteristics Provide a brief history of the institution, a description of its current mission, an indication of its geographic service area, and a description of the composition of the student population. Include a description of any unusual or distinctive features of the institution and a description of the admissions policies (open, selective, etc.). If appropriate, indicate those institutions that are considered peers. Please limit this section to one-half page.

History. Texas A&M University was established in 1871 as the state’s first public institution of higher education and opened for classes in 1876. We are now one of a select few institutions in the nation to hold land grant, sea grant (1971) and space grant (1989) designations. We are also one of few universities to host a presidential library; the George Bush Presidential Library and Museum opened in 1997. A mandatory military component was a part of the land grant designation until 1965 and today we are one of only three institutions with a full-time corps of cadets, leading to commissions in all branches of service. We have two branch campuses, one in Galveston, Texas, (established in 1962, officially merged with Texas A&M in 1991) and one in Doha, Qatar (established in 2003). In 2001 we were admitted to the Association of American Universities (AAU) and in 2004 to Phi Beta Kappa. We are classified by the Carnegie Foundation as a Research University (very high research activity). Mission. Texas A&M University is dedicated to the discovery, development, communication, and application of knowledge in a wide range of academic and professional fields. Its mission of providing the highest quality undergraduate and graduate programs is inseparable from its mission of developing new understandings through research and creativity. It prepares students to assume roles in leadership, responsibility and service to society. Texas A&M assumes as its historic trust the maintenance of freedom of inquiry and an intellectual environment nurturing the human mind and spirit. It welcomes and seeks to serve persons of all racial, ethnic and geographic groups as it addresses the needs of an increasingly diverse population and a global economy. In the 21st century, Texas A&M University seeks to assume a place of preeminence among public universities while respecting its history and traditions. Enrollment Profile. 77.42% Undergraduate, 18.41% Graduate, 4.02% Professional, and 0.14% Post-Doc Certificate

Undergraduate Students: 93.58% Texas Residents, 3.96% non-Texas Residents, 2.46% non-Texas, non-US Residents; 62.41% White, 3.11% Black, 22.33% Hispanic, 6.21% Asian Graduate Students: 45.09% Texas Residents, 16.57% non-Texas Residents, 38.34% non-Texas, non-US Residents Admissions Process. Selective. Automatic admission for Texas resident applicants in the top 10% of their high school graduating class; automatic admission for applicants who rank in the top 25% of their high school graduating class and achieve a combined (old) SAT math and SAT critical reading score of at least 1300 with a test score of at least 600 in each component, or combined (newly redesigned) SAT math and SAT evidence based reading and writing (EBRW) score of at least 1360 with a test score of at least 620 in Math and 660 in EBRW, or 30 composite on the ACT with a 27 in the math and English components; review of all other applicants based on academic potential, distinguishing characteristics, exceptional circumstances and personal achievements. Peer Institutions. Georgia Institution of Technology, Ohio State University, Pennsylvania State University, Purdue University, University of California- Berkeley, Davis, Los Angeles, San Diego, University of Florida, University of Illinois – Champaign/Urbana, University of Michigan, University of Minnesota, University of North Carolina – Chapel Hill, University of Texas – Austin, and University of Wisconsin – Madison.

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2. List of Degrees List all degrees currently offered (A. S., B.A., B.S., M.A., Ph.D., for examples) and the majors or concentrations within those degrees, as well as all certificates and diplomas. For each credential offered, indicate the number of graduates in the academic year previous to submitting this report. Indicate term dates.

College Degree Program Number of Graduates Degree Fall

2015 Spring 2016

Summer 2016

Total

AGRICULTURE AND LIFE SCIENCES

AGRICULTURAL COMMUNICATION & JOURNALISM

BS 35 45 18 98


AGRICULTURAL DEVELOPMENT

MAGR 5 5 0 10


AGRICULTURAL ECONOMICS

BS 45 90 15 150



MS 8 10 7 25



PHD 2 1 3 6


AGRICULTURAL EDUCATION

EDD 1 1 2


AGRICULTURAL LEADERSHIP & DEVELOPMENT

BS 66 102 20 188


AGRICULTURAL LEADERSHIP EDUCATION & COMMUNICATION

MED 5 6 4 15



MS 6 9 1 16



PHD 4 3 3 10


AGRICULTURAL SCIENCE BS 16 33 1 50


AGRICULTURAL SYSTEMS MANAGEMENT

BS 9 23 5 37


AGRICULTURAL SYSTEMS MANAGEMENT

MS 2 2


AGRONOMY MS 1 2 3


AGRONOMY PHD 1 1

AGRICULTURE AND LIFE

ANIMAL BREEDING MS 2 1 1 4

10


2015 Spring 2016

Summer 2016

Total

SCIENCES AGRICULTURE AND LIFE SCIENCES

ANIMAL SCIENCE BS 34 77 12 123


ANIMAL SCIENCE MAGR 6 4 10


ANIMAL SCIENCE MS 6 1 5 12


ANIMAL SCIENCE PHD 2 1 3 6


ANIMAL SCIENCE-PRODUCTION/ INDUSTRY

BS 45 64 22 131


BIOCHEMISTRY BS 9 29 4 42


BIOCHEMISTRY MS 1 3 1 5


BIOCHEMISTRY PHD 2 3 3 8


BIOENVIRONMENTAL SCIENCES

BS 31 44 14 89


BIOLOGICAL AND AGRI ENGINEERING

BS 10 34 44



MENGR

3 3



MS 2 7 9



PHD 2 2 4


COMMUNITY DEVELOPMENT

BS 5 2 7


ECOLOGICAL RESTORATION

BS 3 5 8


Ecosystem Science & Mgmt MS 2 5 7


Ecosystem Science & Mgmt PHD 3 3 1 7


ENTOMOLOGY BS 1 9 1 11

11


2015 Spring 2016

Summer 2016

Total


ENTOMOLOGY MS 5 4 1 10


ENTOMOLOGY PHD 2 1 1 4


FOOD SCI & TCHN-FOOD SCI

BS 5 8 13


FOOD SCI & TCHN-INDUSTRY

BS 5 20 3 28


FORENSIC & INVESTIGATIVE SCIENCES

BS 1 16 1 18


FORESTRY BS 4 6 1 11


GENETICS BS 11 14 25


HORTICULTURE BA 7 9 2 18


HORTICULTURE BS 12 12 3 27


HORTICULTURE MAGR 1 1 2


HORTICULTURE MS 1 3 4


HORTICULTURE PHD 2 1 3


NATURAL RESOURCES DEVELOPMENT

MNRD 1 2 3


NUTRITIONAL SCIENCE BS 55 68 18 141


PHYSIOLOGY OF REPRODUCTION

MS 1 2 3


PHYSIOLOGY OF REPRODUCTION

PHD 1 1


PLANT & ENVRNMNTL SOIL SCIENCE

BS 13 15 3 31


PLANT BREEDING MS 2 5 1 8

12


2015 Spring 2016

Summer 2016

Total


PLANT BREEDING PHD 3 1 1 5


PLANT PATHOLOGY MS 3 2 5


PLANT PATHOLOGY PHD 1 2 1 4


POULTRY SCIENCE BS 3 4 7


POULTRY SCIENCE MAGR 3 1 2 6


POULTRY SCIENCE PHD 3 3


POULTRY SCIENCE-INDUSTRY

BS 8 15 4 27


RANGLND ECL & MGT-RANCH MANAGEMENT

BS 3 9 2 14


RANGLND ECL & MGT-RANGELAND RESOURCES

BS 1 2 3


REC, PARK & TOURISM SCI-COM REC & PRKS ADMIN

BS 4 1 5


REC, PARK & TOURISM SCIENCES

BS 2 8 10 20


REC, PARK & TOURISM SCI-PARKS & CONSERVATION

BS 4 3 7


REC, PARK & TOURISM SCI-TOURISM MANAGEMENT

BS 20 28 11 59


REC, PARK & TOURISM SCI-YOUTH DEVELOPMENT

BS 16 20 5 41


RECREATION, PARK & TOURISM SCI

MS 6 2 8


RECREATION, PARK & TOURISM SCI

PHD 2 3 5


RENEWABLE NATURAL RESOURCES

BS 11 17 28


SOIL SCIENCE MS 3 1 4

13


2015 Spring 2016

Summer 2016

Total


SOIL SCIENCE PHD 1 1 2


SPATIAL SCIENCES BS 2 3 5


TURFGRASS SCIENCE BS 7 3 10


WILDLIFE & FISHERIES SCIENCES

BS 5 3 8



MS 5 2 2 9



PHD 3 2 3 8


WILDLIFE SCIENCE MWSC 3 2 5


WL & FS SCI-VERTEBRATE ZOOLOGY

BS 5 5 4 14


WL & FS SCI-WILDLIFE ECOLOGY & CONSERVATION

BS 32 51 13 96

ARCHITECTURE ARCHITECTURE MARCH

5 38 1 44

ARCHITECTURE ARCHITECTURE MS 1 1 ARCHITECTURE ARCHITECTURE PHD 2 2 1 5 ARCHITECTURE BUILDING

CONSTRUCTION BS 54 116 37 207

ARCHITECTURE CONSTRUCTION MANAGEMENT

MS 8 37 5 50

ARCHITECTURE ENVIRONMENTAL DESIGN ARCHITECHURAL STUDIES

BED 22 62 1 85

ARCHITECTURE LAND & PROPERTY DEVELOPMENT

MLPD 12 7 1 20

ARCHITECTURE LANDSCAPE ARCHITECTURE

BLA 19 19

ARCHITECTURE LANDSCAPE ARCHITECTURE

MLA 20 20

ARCHITECTURE URBAN & REGIONAL PLANNING

BS 4 12 2 18

ARCHITECTURE URBAN & REGIONAL PLANNING

MUP 5 18 6 29

ARCHITECTURE URBAN & REGIONAL SCIENCE

PHD 3 1 6 10

ARCHITECTURE VISUALIZATION MFA 3 1 4

14


2015 Spring 2016

Summer 2016

Total

ARCHITECTURE VISUALIZATION MS 4 3 2 9 ARCHITECTURE VISUALIZATION BS 13 38 6 57 BUSH SCHOOL OF GOVERNMENT & PUBLIC SERVICE

HOMELAND SECURITY CERTIFICATE

CER 1 10 11

BUSH SCHOOL OF GOVERNMENT & PUBLIC SERVICE

INTERNATIONAL AFFAIRS MIA 8 81 6 95


INTERNATIONAL AFFAIRS CERTIFICATE

CER 10 22 12 44


NON-PROFIT MANAGEMENT CERTIFICATE

CER 13 20 10 43


PUBLIC SERVICE AND ADMINISTRATION

MPSA 1 64 4 69

BUSINESS ACCOUNTING BBA 37 271 12 320 BUSINESS ACCOUNTING MS 15 115 8 138 BUSINESS BUSINESS

ADMINISTRATION MBA 51 3 4 58

BUSINESS BUSINESS ADMINISTRATION

PHD 1 5 13 19

BUSINESS BUSINESS HONORS BBA 6 52 1 59 BUSINESS EXECUTIVE MBA MBA 1 49 50 BUSINESS FINANCE BBA 49 180 13 242 BUSINESS FINANCE MS 16 95 1 112 BUSINESS FINANCIAL MANAGEMENT MFM 1 1 BUSINESS LAND ECONOMICS & REAL

ESTATE MRE 14 9 2 25

BUSINESS MANAGEMENT BBA 36 131 12 179 BUSINESS MANAGEMENT MS 33 49 2 84 BUSINESS MANAGEMENT

INFORMATION SYSTEMS BBA 13 35 3 51

BUSINESS MANAGEMENT INFORMATION SYSTEMS

MS 5 149 2 156

BUSINESS MARKETING BBA 47 144 15 206 BUSINESS MARKETING MS 30 8 38 BUSINESS PROFESSIONAL MBA MBA 46 46

15


2015 Spring 2016

Summer 2016

Total

BUSINESS SUPPLY CHAIN MANAGEMENT

BBA 36 130 7 173

DENTISTRY ADVANCED EDUCATON IN GENERAL DENTISTRY

CER 9 9

DENTISTRY DENTAL HYGIENE BS 25 25 DENTISTRY DENTISTRY DDS 1 103 1 105 DENTISTRY ENDODONTICS CER 3 3 DENTISTRY MAXILLOFACIAL

SURGERY CER 3 3

DENTISTRY ORAL AND MAXILLOFACIAL PATHOLOGY

CER 1 1

DENTISTRY ORAL BIOLOGY MS 1 12 13 DENTISTRY ORTHODONTICS CER 6 6 DENTISTRY PEDIATRIC DENTISTRY CER 11 11 DENTISTRY PERIODONTICS CER 3 3 DENTISTRY PROSTHODONTICS CER 2 2 EDUCATION & HUMAN DEVELOPMENT

ATHLETIC TRAINING MS 14 14

EDUCATION & HUMAN DEVELOPMENT

BILINGUAL EDUCATION MED 1 3 4


COMMUNITY HEALTH BS 19 60 39 118


COUNSELING PSYCHOLOGY

PHD 1 5 6


CURRICULUM & INSTRUCTION

EDD 4 4 8



MED 15 60 50 125



MS 2 2



PHD 4 9 5 18


EDUC HUMAN RESOURCE DEVELOPMENT

MS 14 18 7 39


EDUC HUMAN RESOURCE DEVELOPMENT

PHD 3 4 7


EDUCATIONAL ADMINISTRATION

EDD 3 4 7

EDUCATION & EDUCATIONAL MED 7 13 20

16


2015 Spring 2016

Summer 2016

Total

HUMAN DEVELOPMENT

ADMINISTRATION



MS 2 20 2 24



PHD 7 1 5 13


EDUCATIONAL PSYCHOLOGY

MED 12 30 3 45



MS 1 2 3



PHD 6 4 5 15


EDUCATIONAL TECHNOLOGY

MED 4 10 4 18


HEALTH BS 115 187 38 340


HEALTH EDUCATION MS 8 10 5 23


HEALTH EDUCATION PHD 4 1 1 6


HUMAN RESOURCES DEVELOPMENT

BS 23 52 36 111


INTERDISCIPLINARY STUDIES

BS 157 243 2 402


KINESIOLOGY BS 73 106 42 221


KINESIOLOGY MS 4 13 3 20


KINESIOLOGY PHD 6 5 7 18


SCHOOL PSYCHOLOGY PHD 6 6


SPECIAL EDUCATION MED 24 5 29


SPORTS MANAGEMENT BS 42 60 34 136

EDUCATION & SPORTS MANAGEMENT MS 15 16 15 46

17


2015 Spring 2016

Summer 2016

Total

HUMAN DEVELOPMENT EDUCATION & HUMAN DEVELOPMENT

TECHNOLOGY MANAGMENT

BS 21 33 7 61

ENGINEERING AEROSPACE ENGINEERING

BS 30 52 1 83


MENGR

3 2 1 6


MS 1 3 7 11


PHD 2 2 2 6

ENGINEERING BIOMEDICAL ENGINEERING

BS 7 63 1 71


MENGR

3 1 4


MS 2 2 3 7


PHD 5 4 3 12

ENGINEERING CHEMICAL ENGINEERING BS 47 74 10 131 ENGINEERING CHEMICAL ENGINEERING MENG

R 2 2 1 5

ENGINEERING CHEMICAL ENGINEERING MS 2 10 14 26 ENGINEERING CHEMICAL ENGINEERING PHD 6 10 4 20 ENGINEERING CIVIL ENGINEERING BS 91 93 5 189 ENGINEERING CIVIL ENGINEERING MENG

R 54 52 16 122

ENGINEERING CIVIL ENGINEERING MS 11 9 7 27 ENGINEERING CIVIL ENGINEERING PHD 14 8 11 33 ENGINEERING COMPUTER ENGINEERING MENG

R 27 40 4 71

ENGINEERING COMPUTER ENGINEERING MS 7 5 6 18 ENGINEERING COMPUTER ENGINEERING PHD 3 2 4 9 ENGINEERING COMPUTER ENGINEERING BS 24 36 3 63 ENGINEERING COMPUTER ENGINEERING MS 4 2 2 8 ENGINEERING COMPUTER ENGINEERING PHD 4 1 5 ENGINEERING COMPUTER ENGINEERING BS 11 21 32 ENGINEERING COMPUTER ENGINEERING MENG

R 3 5 8

ENGINEERING COMPUTER SCIENCE BS 48 63 9 120 ENGINEERING COMPUTER SCIENCE MCS 17 24 2 43 ENGINEERING COMPUTER SCIENCE MS 6 9 6 21 ENGINEERING COMPUTER SCIENCE PHD 7 8 8 23 ENGINEERING ELECTRICAL

ENGINEERING BS 90 115 10 215

ENGINEERING ELECTRICAL ENGINEERING

MENGR

21 54 7 82

18


2015 Spring 2016

Summer 2016

Total


MS 11 14 11 36


PHD 11 18 13 42

ENGINEERING ELECTRONIC SYSTEMS ENGINEERING TECHNOLOGY

BS 19 26 4 49

ENGINEERING ENGINEERING DENGR

1 1

ENGINEERING ENGINEERING SYSTEMS MANAGEMENT

MS 3 18 1 22

ENGINEERING ENGR TCHN-MANUFACTURING & MCHNCL ENGR

BS 41 49 2 92

ENGINEERING HEALTH PHYSICS MS 2 2 ENGINEERING INDUSTRIAL

DISTRIBUTION MID 1 66 67

ENGINEERING INDUSTRIAL DISTRIBUTION

BS 76 84 9 169

ENGINEERING INDUSTRIAL ENGINEERING

BS 83 87 6 176


MENGR

10 29 12 51


MS 2 19 3 24


PHD 5 1 5 11

ENGINEERING INTERDISCIPLINARY ENGINEERING

PHD 1 1

ENGINEERING MATERIALS SCIENCE & ENGINEERING

MENGR

1 1 1 3


MS 3 2 4 9


PHD 3 4 3 10

ENGINEERING MECHANICAL ENGINEERING

BS 92 151 33 276


MENGR

8 12 4 24


MS 21 13 20 54


PHD 9 9 15 33

ENGINEERING NUCLEAR ENGINEERING BS 6 19 1 26 ENGINEERING NUCLEAR ENGINEERING MENG

R 1 1 2

ENGINEERING NUCLEAR ENGINEERING MS 6 9 6 21 ENGINEERING NUCLEAR ENGINEERING PHD 5 7 9 21 ENGINEERING OCEAN ENGINEERING BS 9 25 1 35 ENGINEERING OCEAN ENGINEERING MENG

R 3 1 1 5

ENGINEERING OCEAN ENGINEERING MS 3 3 1 7

19


2015 Spring 2016

Summer 2016

Total

ENGINEERING OCEAN ENGINEERING PHD 1 2 3 ENGINEERING PETROLEUM

ENGINEERING BS 45 114 5 164

ENGINEERING PETROLEUM ENGINEERING

MENGR

10 16 9 35


MS 22 15 28 65


PHD 3 6 5 14

ENGINEERING RADIOLOGICAL HEALTH ENGINEERING

BS 4 15 19

ENGINEERING SAFETY ENGINEERING MS 7 2 1 10 GEOSCIENCES ATMOSPHERIC SCIENCE MS 3 2 6 11 GEOSCIENCES ATMOSPHERIC SCIENCE PHD 1 1 1 3 GEOSCIENCES ENVIRONMENTAL

GEOSCIENCE BS 18 21 1 40

GEOSCIENCES GEOGRAPHIC INFORMATIONAL STUDIES

BS 4 7 2 13

GEOSCIENCES GEOGRAPHY BS 3 12 2 17 GEOSCIENCES GEOGRAPHY MS 1 2 4 7 GEOSCIENCES GEOGRAPHY PHD 1 1 3 5 GEOSCIENCES GEOLOGY BA 3 4 7 GEOSCIENCES GEOLOGY BS 19 31 25 75 GEOSCIENCES GEOLOGY MS 6 5 4 15 GEOSCIENCES GEOLOGY PHD 2 3 1 6 GEOSCIENCES GEOPHYSICS BS 11 21 2 34 GEOSCIENCES GEOPHYSICS MS 1 2 4 7 GEOSCIENCES GEOPHYSICS PHD 1 1 1 3 GEOSCIENCES GEOSCIENCES MGSC 1 1 GEOSCIENCES METEOROLOGY BS 4 14 1 19 GEOSCIENCES OCEANOGRAPHY MS 1 4 5 10 GEOSCIENCES OCEANOGRAPHY PHD 3 3 GEOSCIENCES SPATIAL SCIENCES BS 1 1 LIBERAL ARTS ANTHROPOLOGY BA 15 31 4 50 LIBERAL ARTS ANTHROPOLOGY MA 3 1 2 6 LIBERAL ARTS ANTHROPOLOGY PHD 2 4 3 9 LIBERAL ARTS CLASSICS BA 3 1 2 6 LIBERAL ARTS CLINICAL PSYCHOLOGY PHD 2 2 LIBERAL ARTS COMMUNICATION BA 88 147 36 271 LIBERAL ARTS COMMUNICATION MA 1 1 1 3 LIBERAL ARTS COMMUNICATION PHD 5 2 3 10 LIBERAL ARTS ECONOMICS BA 5 13 5 23 LIBERAL ARTS ECONOMICS BS 68 95 36 199 LIBERAL ARTS ECONOMICS MS 30 55 85

20


2015 Spring 2016

Summer 2016

Total

LIBERAL ARTS ECONOMICS PHD 8 4 12 LIBERAL ARTS ENGLISH BA 55 92 17 164 LIBERAL ARTS ENGLISH MA 3 3 2 8 LIBERAL ARTS ENGLISH PHD 1 2 5 8 LIBERAL ARTS HISPANIC STUDIES PHD 1 1 2 LIBERAL ARTS HISTORY BA 48 99 18 165 LIBERAL ARTS HISTORY MA 2 2 4 LIBERAL ARTS HISTORY PHD 2 4 1 7 LIBERAL ARTS INDUSTRIAL/ORGANIZATI

ONAL PSYCHOLOGY PHD 5 5

LIBERAL ARTS INTERNATIONAL STUDIES BA 53 81 13 147 LIBERAL ARTS MODERN LANGUAGES BA 1 3 4 LIBERAL ARTS MUSIC BA 2 8 10 LIBERAL ARTS PERFORMANCE STUDIES MA 7 1 8 LIBERAL ARTS PHILOSOPHY BA 9 12 5 26 LIBERAL ARTS PHILOSOPHY MA 2 1 3 LIBERAL ARTS PHILOSOPHY PHD 2 2 LIBERAL ARTS POLITICAL SCIENCE BA 38 90 31 159 LIBERAL ARTS POLITICAL SCIENCE BS 21 48 7 76 LIBERAL ARTS POLITICAL SCIENCE MA 2 1 3 LIBERAL ARTS POLITICAL SCIENCE PHD 3 2 2 7 LIBERAL ARTS PSYCHOLOGY BA 29 55 9 93 LIBERAL ARTS PSYCHOLOGY BS 83 166 27 276 LIBERAL ARTS PSYCHOLOGY MS 3 3 LIBERAL ARTS PSYCHOLOGY PHD 2 1 1 4 LIBERAL ARTS SOCIOLOGY BA 16 30 11 57 LIBERAL ARTS SOCIOLOGY BS 25 66 22 113 LIBERAL ARTS SOCIOLOGY MS 3 1 4 LIBERAL ARTS SOCIOLOGY PHD 3 6 9 LIBERAL ARTS SPANISH BA 11 18 7 36 LIBERAL ARTS TELECOMMUNICATION

MEDIA STUDIES BA 21 24 5 50

LIBERAL ARTS TELECOMMUNICATION MEDIA STUDIES

BS 6 5 2 13

LIBERAL ARTS THEATER ARTS BA 3 9 2 14 LIBERAL ARTS WOMEN'S AND GENDER

STUDIES BA 1 2 3

MEDICINE EDUCATION FOR HEALTHE CARE PROFESSIONALS

MS 2 2 2 6

MEDICINE MEDICAL SCIENCES MS 3 3 6 MEDICINE MEDICAL SCIENCES PHD 1 2 3 6 MEDICINE MEDICINE MD 9 185 194

21


2015 Spring 2016

Summer 2016

Total

NURSING FAMILY NURSE PRACTITIONER

MSN 11 11

NURSING NURSING BSN 10 122 132 NURSING NURSING EDUCATION MSN 8 8 PHARMACY PHARMACY PHAR

MD 1 77 78

PUBLIC HEALTH BOISTATISTICS MPH 3 3 PUBLIC HEALTH ENVIRONMENTAL HEALTH MPH 2 17 1 20 PUBLIC HEALTH ENVIRONMENTAL HEALTH MSPH 1 1 2 PUBLIC HEALTH EPIDEMIOLOGY MPH 9 19 24 52 PUBLIC HEALTH EPIDEMIOLOGY AND

ENVIRONMENTAL HEALTH DRPH 1 1 2

PUBLIC HEALTH HEALTH ADMINISTRATION MHA 1 20 21 PUBLIC HEALTH HEALTH POLICY AND

MANAGMENT MPH 6 21 1 28

PUBLIC HEALTH HEALTH PROMOTION AND COMMUNITY HEALTH SCIENCES

DRPH 1 2 3

PUBLIC HEALTH HEALTH PROMOTION AND COMMUNITY HEALTH SCIENCES

MPH 3 15 9 27

PUBLIC HEALTH HEALTH SERVICES RESEARCH

PHD 2 4 1 7

PUBLIC HEALTH OCCUPATIONAL SAFETY AND HEALTH

MPH 1 6 7

SCIENCE ANALYTICS MS 21 1 22 SCIENCE APPLIED MATHEMATICAL

SCIENCES BS 18 42 6 66

SCIENCE APPLIED PHYSICS PHD 2 1 3 SCIENCE BIOLOGY BA 10 22 1 33 SCIENCE BIOLOGY BS 54 133 10 197 SCIENCE BIOLOGY MS 3 1 4 SCIENCE BIOLOGY PHD 2 4 4 10 SCIENCE CHEMISTRY BA 8 18 2 28 SCIENCE CHEMISTRY BS 14 24 1 39 SCIENCE CHEMISTRY MS 1 2 2 5 SCIENCE CHEMISTRY PHD 15 8 22 45 SCIENCE MATHEMATICS BA 5 16 2 23 SCIENCE MATHEMATICS BS 2 5 7 SCIENCE MATHEMATICS MS 6 21 5 32 SCIENCE MATHEMATICS PHD 5 4 16 25 SCIENCE MICROBIOLOGY BS 3 14 1 18 SCIENCE MICROBIOLOGY MS 1 1 SCIENCE MICROBIOLOGY PHD 1 1 SCIENCE MOLECULAR & CELL

BIOLOGY BS 8 12 1 21

22


2015 Spring 2016

Summer 2016

Total

SCIENCE PHYSICS BA 6 1 7 SCIENCE PHYSICS BS 1 17 1 19 SCIENCE PHYSICS MS 3 2 2 7 SCIENCE PHYSICS PHD 7 10 10 27 SCIENCE STATISTICS MS 14 27 17 58 SCIENCE STATISTICS PHD 2 2 SCIENCE ZOOLOGY BS 2 8 3 13 TAMU AT GALVESTON

MARINE BIOLOGY BS 39 70 6 115

TAMU AT GALVESTON

MARINE ENGINEERING TECHNOLOGY

BS 4 13 5 22

TAMU AT GALVESTON

MARINE FISHERIES BS 7 11 18

TAMU AT GALVESTON

MARINE RESOURCES MANAGMENT

MMRM 4 7 2 13

TAMU AT GALVESTON

MARINE SCIENCES BS 3 2 5

TAMU AT GALVESTON

MARINE TRANSPORTATION

BS 41 18 21 80

TAMU AT GALVESTON

MARITIME ADMINISTRATION

BS 42 61 14 117

TAMU AT GALVESTON

MARITIME ADMINISTRATION & LOGISTICS

MMAL 7 5 2 14

TAMU AT GALVESTON

MARITIME STUDIES BA 6 6 3 15

TAMU AT GALVESTON

OCEAN AND COASTAL RESOURCES

BS 6 9 2 17

TAMU AT GALVESTON

OFFSHORE & COASTAL SYSTEMS ENGINEERING

BS 20 20

TEXAS A&M SCHOOL OF LAW

LAW JD 41 159 5 205

UNIVERSITY INTERDISCIPLINARY

AGRIBUSINESS BS 29 61 2 92


AGRIBUSINESS MAB 20 6 26


BIOTECHNOLOGY MBIOT 7 10 1 18


ENVIRONMENTAL STUDIES

BS 24 22 7 53


FOOD SCIENCE & TECHNOLOGY

MS 2 2 4


FOOD SCIENCE & TECHNOLOGY

PHD 1 2 3 6

23


2015 Spring 2016

Summer 2016

Total


GENETICS MS 1 1 1 3


GENETICS PHD 4 4 1 9


MARINE BIOLOGY MS 3 9 1 13


MARINE BIOLOGY PHD 4 4


MOLECULAR & ENVIRONMENTAL PLANT SCIENCE

MS 1 1 2 4


MOLECULAR & ENVIRONMENTAL PLANT SCIENCE

PHD 1 2 3


NEUROSCIENCE MS 2 2


NEUROSCIENCE PHD 1 1


NUTRITION MS 3 3


NUTRITION PHD 2 1 3


TOXICOLOGY MS 2 2


TOXICOLOGY PHD 1 1 1 3


UNIVERSITY STUDIES - AGRICULTURE

BS 31 42 21 94


UNIVERSITY STUDIES - ARCHITECTURE

BS 15 24 22 61


UNIVERSITY STUDIES - BUSINESS ADMIN

BS 34 43 14 91


UNIVERSITY STUDIES - EDUCATION

BS 25 38 23 86


UNIVERSITY STUDIES - GALVESTON

BS 3 1 4


UNIVERSITY STUDIES - GEOSCIENCES

BS 1 1 1 3

24


2015 Spring 2016

Summer 2016

Total


UNIVERSITY STUDIES - LIBERAL ARTS

BA 1 3 4


UNIVERSITY STUDIES - LIBERAL ARTS

BS 5 3 1 9


UNIVERSITY STUDIES - SCIENCE

BS 2 2 1 5


UNIVERSITY STUDIES - VETERINARY MED

BS 5 9 5 19


WATER MANAGEMENT AND HYDRO SCI

MS 3 4 7



MWM 2 4 2 8



PHD 3 1 1 5

VETERINARY MEDICINE & BIOMEDICAL SCIENCES

BIOMEDICAL SCIENCES BS 91 173 37 301


BIOMEDICAL SCIENCES MS 23 32 16 71


BIOMEDICAL SCIENCES PHD 2 1 3 6


SCIENCE & TECHNOLOGY JOURNALISM

MS 1 4 5


VETERINARY MEDICINE DVM 129 129


VETERINARY PATHOBIOLOGY

PHD 3 1 4


VETERINARY PUBLIC HEALTH - EPIDEMIOLOGY

MS 2 2

25

3. Off-Campus Instructional Locations and Branch Campuses List all locations where 50% or more credit hours toward a degree, diploma, or certificate can be obtained primarily through traditional classroom instruction. Report those locations in accord with the Commission’s definitions and the directions as specified below. Off-campus instructional sites—a site located geographically apart from the main campus at which the institution offers 50 % or more of its credit hours for a diploma, certificate, or degree. This includes high schools where courses are offered as part of dual enrollment. For each site, provide the information below. The list should include only those sites reported and approved by SACSCOC. Listing unapproved sites below does not constitute reporting them to SACSCOC. In such cases when an institution has initiated an off-campus instructional site as described above without prior approval by SACSCOC, a prospectus for approval should be submitted immediately to SACSCOC. Off-Campus Instructional Locations – 50% or more. Name of Site Physical Address

(street, city, state, country) Do not include PO Boxes.





Texas A&M Health Science Center

8441 State Highway 47 Clinical Building 1, Suite 3100 Bryan, TX 77807

2000 2000 EDUCATION FOR HEALTHCARE PROFESSIONALS

MS Yes

MEDICAL SCIENCES MD MEDICAL SCIENCES MS MEDICAL SCIENCES PHD MEDICINE MD NURSING BSN NURSING EDUCATION

MSN

PHARMACY PHMD FAMILY NURSE PRACTITIONER

MSN

Arabian Society for Human Resource Management

Saudi Aramco – Box 8926 Training & Career Development South Administration Building, Room 242 Dhahran 31311 Saudi Arabia

2012 2007 HUMAN RESOURCE MANAGEMENT

MS Yes

City Centre 842 West Sam Houston Parkway North, Suite 200 Houston, Texas 77024-3920

2012 2012 ANALYTICS MS Yes

BUSINESS ADMINISTRATION

MBA

College of Dentistry

3302 Gaston Ave. Dallas, TX 75246

2001 2000

ADVANCED EDUCATON IN GENERAL DENTISTRY

CTGFA Yes

DENTAL HYGIENE BS DENTAL PUBLIC HEALTH

Certificate

DENTISTRY DDS ENDODONTICS CTGFA MAXILLOFACIAL SURGERY

CTGFA

ORAL AND MAXILLOFACIAL PATHOLOGY

CTGFA

ORAL AND MAXILLOFACIAL

CTGFA

26

Name of Site Physical Address (street, city, state, country) Do not include PO Boxes.





RADIOLOGY ORAL BIOLOGY MS ORAL BIOLOGY PHD ORTHODONTICS CTGFA PEDIATRIC DENTISTRY

CTGFA

PERIODONTICS CTGFA PROSTHODONTICS CTGFA

Institute of Biosciences and Technology

2121 W. Holcombe Blvd. Houston, TX 77030

2000 2000

HEALTH ADMINISTRATION

MHA Yes

MEDICINE MD

Rangel College of Pharmacy

1010 W. Avenue B. Kingsville, TX 78363

2011 2006

PHARMACY PHMD Yes

College of Medicine - Temple

2401 S. 31st Street Temple, TX 76508

2000 2000

MEDICINE MD Yes

MEDICAL SCIENCES PHD

Clinical Learning Resource Center

Health Professions Building 3950 North A. W. Grimes Blvd. Round Rock, TX 78665

2011 2010

MEDICINE MD Yes

NURSING BSN

Rural Public Health - McAllen Teaching Site

2101 South McColl Road McAllen, TX 78503

2011 2010

HEALTH POLICY AND MANAGMENT

MPH Yes

HEALTH PROMOTION AND COMMUNITY HEALTH SCIENCES

MPH

NURSING BSN Texas A&M University School of Law

1515 Commerce St Fort Worth, TX 76102

2013 2013 HEALTH CARE LAW JM Yes INTELLECTUAL PROPERTY

ML

INTELLECTUAL PROPERTY

MJ

JURISPRUDENCE MJ LAW JD LAWS ML

Houston Methodist Hospital

6670 Bertner Avenue, R2-216 Houston, TX 77030

2015 2015 MEDICINE MD Yes

Baylor University Medical Center

3500 Gaston Avenue Dallas, TX 75246

2012 2011 MEDICINE MD Yes

27

Off-Campus Instructional Locations – 25%-49%. Name of Site (Indicate if site is currently active or inactive. If inactive, date of last course offerings and date of projected reopening


Date Notified SACSCOC


Educational programs offered (specific degrees, certificates, diplomas) with 25-49% credit hours offered at each site


Department of State Health Services

1100 West 49th Austin, TX. 78756

2011

2004

HEALTH POLICY & MANAGEMENT - MPH

Branch Campuses

Name of Branch Campus




Educational programs (specific degrees, certificates, diplomas) with 50% or more credits hours offered at the branch campus

Is the campus currently active? (At any time during the past 5 years, have students been enrolled and courses offered? If not, indicate the date of most recent activity.)

Texas A&M University at Galveston

200 Seawolf Pkwy. Galveston, TX 77553

1992

1991

MARINE BIOLOGY BS Yes

OFFSHORE & COASTAL SYSTEMS ENGINEER BS

MARINE BIOLOGY MS

MARINE BIOLOGY PHD

MARINE ENGINEERING TECHNOLOGY

BS

MARINE FISHERIES

BS

MARINE RESOURCES MANAGMENT

MMR

MARINE SCIENCES

BS

MARINE TRANSPORTATION

BS

MARITIME ADMINISTRATION

BS

MARITIME ADMINISTRATION & LOGISTICS

MML

MARITIME STUDIES

BA

OCEAN AND COASTAL RESOURCES

BS

OCEAN ENGINEERING

BS

UNIVERSITY STUDIES –

BS

28

GALVESTON

Texas A&M University at Qatar

253 Texas A&M Qatar Engineering Building Education City Al Luqta St Doha, Qatar

2005 2003

CHEMICAL ENGINEERING

BS Yes


MS


MEN

ELECTRICAL ENGINEERING

BS

MECHANICAL ENGINEERING

BS

PETROLEUM ENGINEERING

BS

4. Distance and Correspondence Education Provide an initial date of approval for your institution to offer distance education. Provide a list of credit-bearing educational programs (degrees, certificates, and diplomas) where 50% or more of the credit hours are delivered through distance education modes. For each educational program, indicate whether the program is delivered using synchronous or asynchronous technology, or both. For each educational program that uses distance education technology to deliver the program at a specific site (e.g., a synchronous program using interactive videoconferencing), indicate the program offered at each location where students receive the transmitted program. Please limit this description to one page, if possible. Initial Approval in February 2000

CreditBearingDegreePrograms Site Synchronous/Asynchronous/Both

AEROSPACEENGINEERING MENGR AsynchronousAGRICULTURALDEVELOPMENT MAGR Asynchronous

AGRICULTURALEDUCATION EDD

SynchronouscourseofferedworldwideviaPCorLMS

Both

AGRICULTURALSYSTEMSMANAGEMENT MS Asynchronous

ANALYTICS MS AsynchronousBILINGUALEDUCATION MED AsynchronousBILINGUALEDUCATION MS AsynchronousBIOLOGICALANDAGRIENGINEERING MENGR Asynchronous

COMPUTERENGINEERING MENGR


Both

CURRICULUM&INSTRUCTION EDD AsynchronousCURRICULUM&INSTRUCTION MED Asynchronous

29

EDUCHUMANRESOURCEDEVELOPMENT MS Asynchronous

EDUCATIONFORHEALTHCAREPROFESSIONALS MS Asynchronous

EDUCATIONALADMINISTRATION MED Asynchronous

EDUCATIONALPSYCHOLOGY MED


Both

EDUCATIONALPSYCHOLOGY MS AsynchronousEDUCATIONALTECHNOLOGYMED AsynchronousELECTRICALENGINEERING MENGR AsynchronousENERGY MS AsynchronousENGINEERING MENGR AsynchronousENGINEERINGSYSTEMSMANAGEMENT MS Asynchronous

EPIDEMIOLOGY MPH AsynchronousFAMILYNURSEPRACTITIONER MSN Bryan,TX BothHEALTHEDUCATION MS Asynchronous

INDUSTRIALDISTRIBUTION MID CollegeStation,TX Both

INDUSTRIALENGINEERINGMENGR AsynchronousLAWS LLM AsynchronousJURISPRUDENCE MJ AsynchronousMARITIMEADMINISTRATION&LOGISTICS MMAL Asynchronous

MATHEMATICS MS AsynchronousMECHANICALENGINEERING MENGR AsynchronousNATURALRESOURCESDEVELOPMENT MNRD Asynchronous

NURSING BSN AsynchronousNURSINGEDUCATION MSN Bryan,TX BothPETROLEUMENGINEERING MENGR AsynchronousPLANTBREEDING MS AsynchronousPLANTBREEDING PHD AsynchronousPOULTRYSCIENCE MAGR AsynchronousPUBLICSERVICEANDADMINISTRATION MPSA CollegeStation,

TX Both

RECREATION&RESOURCESDEVELOPMENT MRRD CollegeStation,TX Both

SAFETYENGINEERING MS Asynchronous

30

SPECIALEDUCATION MED


Synchronous

SPECIALEDUCATION MS


Synchronous

SPORTSMANAGEMENT MS AsynchronousSTATISTICS MS AsynchronousWILDLIFESCIENCE MWSC AsynchronousMILITARYLANDSUSTAINABILITY CERT AsynchronousADVANCEDINTERNATIONALAFFAIRS CERT CollegeStation,

TX;Houston,TX Both

AGRICULTUREE-LEARNINGDEVELOPMENT CERT Asynchronous

APPLIEDBEHAVIORANALYSIS CERT AsynchronousEDUCATIONFORHEALTHECAREPROFESSIONALS CERT Asynchronous

ENERGY CERT AsynchronousENERGYSUSTAINABILITYENGINEERING CERT Asynchronous

FORENSICHEALTHCARE CERT AsynchronousHOMELANDSECURITY CERT AsynchronousINDUSTRIALDATAANALYTICS CERT Asynchronous

NATIONALSECURITYAFFAIRS CERTCollegeStation,TX;Livermore,CA;Sandia,NM

Both

NONPROFITMANAGEMENT CERT CollegeStation,TX;Houston,TX Both

PUBLICHEALTH CERT McAllen,TX BothREGULATORYSCIENCEINFOODSYSTEMS CERT Asynchronous

SAFETYENGINEERING CERT AsynchronousAPPLIEDSTATISTICS CERT Asynchronous 5. Accreditation AccreditationCouncilforPharmacyEducation

Thepharmacyprofessionaldegreeprogram

LastReview:April2014

AmericanCouncilforConstructionEducation

TheB.S.andM.S.curriculuminconstructionscience

LastReview:2011(B.S.)and2012(M.S.)

AmericanPsychological Theclinicalpsychologyprogram LastReview:April/May2015

31

Association intheDepartmentofPsychologyandthecounselingpsychologyandschoolpsychologyprogramintheDepartmentofEducationalPsychology

AmericanVeterinaryMedicalAssociationCouncilonEducation

Theveterinarymedicinedegreeprogram

LastReview:2013

AssociationtoAdvanceCollegiateSchoolsofBusiness(AACSB)

Thebusinessbaccalaureate,master’s,anddoctoralprogramsinMaysBusinessSchool

LastReview:Fall2012

CommissiononAccreditationforDieteticsEducation

Thedietetictrackinthenutritionalsciencescurriculumandthedieteticinternshipprogram

Lastreview:January2015

CommissiononAccreditationofAthleticTrainingEducation(caATe)

AthleticTraining(CollegeofEducation)

LastReview:2013

CommissiononAccreditationofHealthcareManagementEducation

TheMasterofHealthAdministration

LastReview:Fall2010

CommissiononCollegiateNursingEducationandtheTexasBoardofNursing

Thenursingdegreeprograms LastReview:July2013

CommissiononDentalAccreditation.(CODA)

Thedegreeprogramsindentistryanddentalhygieneandthecertificateprogramsinthetenadvanceddentalgraduateeducationprograms

LastReview:August2013

CommissiononEnglishLanguageProgramAccreditation(CEA)

TheEnglishLanguageInstitute Lastreview:2013

ComputingAccreditationCommissionofABET

Thecomputerscienceprogram Lastreview:2010

CounciloftheSectionofLegalEducationandAdmissionstotheBaroftheAmericanBarAssociation

TexasA&MUniversitySchoolofLaw

Lastreview:2010

CouncilonEducationforPublicHealth

TheSchoolofPublicHealthdegreeprograms

LastReview:April2011

EngineeringAccreditationCommissionofABET

Undergraduateprogramsinaerospace,biologicalandagricultural,biomedical,chemical,civil,computer,electrical,industrial,mechanical,nuclear,ocean,petroleumandradiologicalhealthengineering

LastReview:2010-2011(CollegeStation)and2015(Qatar)

EngineeringAccreditationCommissionofABET

Maritimesystemsengineering(OffshoreandCoastalSystemsEngineering)–TAMUGalveston

Lastreview:2010-11

32

EngineeringTechnologyAccreditationCommissionofABET

Theelectronicsystemsengineeringtechnologyprogram,themanufacturingandmechanicalengineeringtechnologyprogram,

LastReview:2013-2014(CollegeStation)and2015(Qatar)

EngineeringTechnologyAccreditationCommissionofABET

marineengineeringtechnology–TAMUGalveston

LastReview:2013-14

ForensicScienceEducationProgramsAccreditationCommission(FEPAC)

Theforensicsandinvestigativesciencesprogram

LastSiteVisit:October2011Accreditationdates:1/2012-1/2017)

InstituteofFoodTechnologists Thefoodscienceandtechnologycurriculum

LastReview:December2011

LandscapeArchitecturalAccreditationBoard

The curriculum in landscapearchitecture

LastReview:July2015

LiaisonCommitteeonMedicalEducation

Themedicaleducationdegreeprogram

LastReview:August2012

NationalArchitecturalAccreditingBoard

Thecurriculuminarchitecture LastReview:March2013

NetworkofSchoolsofPublicPolicy,Affairs,andAdministration

TheMasterofPublicServiceandAdministrationdegreeintheBushSchoolofGovernmentandPublicService

Lastreview:April2014

NationalRecreationandParkAssociation

Thecurriculuminrecreation,parkandtourismsciences

LastReview:June2010

PlanningAccreditationBoard TheMasterofUrbanPlanningcurriculum

LastReview:2013

SocietyforRangeManagement

Thecurriculuminrangelandecologyandmanagement

LastReview:2006

SocietyofAmericanForesters Thecurriculuminforestry LastReview:2013

StateBoardofEducatorCertificationTexasEducationAgency

ProgramsinprofessionaleducationanddegreesconferredbyTexasA&MUniversity

Lastreview2011

(2) If SACS Commission on Colleges is not your primary accreditor for access to USDOE Title IV funding, identify which accrediting agency serves that purpose. Not applicable. (3) List any USDOE recognized agency (national and programmatic) that has terminated the institution’s

accreditation (include the date, reason, and copy of the letter of termination) or list any agency from which the institution has voluntarily withdrawn (include copy of letter to agency from institution).

None.

33

(4) Describe any sanctions applied or negative actions taken by any USDOE-recognized accrediting

agency (national, programmatic, SACSCOC) during the two years previous to the submission of this report. Include a copy of the letter from the USDOE to the institution. None.

6. Relationship to the U.S. Department of Education. Texas A&M University does not have any limitations or suspensions, nor have we been terminated by the U.S. Department of Education in regard to student financial aid or other financial aid programs during the previous three years. We are not on reimbursement nor do we have any other exceptional status in regard to federal or state financial aid.

Appendix G

Faculty Curriculum Vitae

Program Director/Principal Investigator (Last, First, Middle): ARAMAYO, Rodolfo

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors.

Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME Aramayo, Rodolfo

POSITION TITLE Associate Professor

eRA COMMONS USER NAME (credential, e.g., agency login) raramyo EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)

INSTITUTION AND LOCATION DEGREE (if applicable) MM/YY FIELD OF STUDY

University of Brasília BSc 1982 Molecular Biology University of Brasília MSc 1986 Molecular Biology University of Georgia PhD 1992 Genetics University of Wisconsin, Madison Postdoctoral 1996 Genetics Stanford University Postdoctoral 1997 Genetics

A. Personal Statement I am a fungal molecular geneticist. I obtained a Masters degree in Molecular Biology, working on the isolation and purification of peptides produced by Bacillus subtitilis with antifungal activity. I attended the University of Georgia, in Athens, where I obtained a PhD degree in Genetics, working under the supervision of Dr. William E. Timberlake in the genetic and molecular characterization of the asexual sporulation pathway of Aspergillus nidulans. For my Post-doctoral studies, I broaden my knowledge of genetics and fungal biology by studying the sexual developmental pathway of Neurospora crassa working under the supervision of the late Dr. Robert L. Metzenberg. During this time, I discovered an unusual genetic meiotic phenomenon we called Meiotic Silencing. In 1997, I moved from Stanford to Texas A&M University where, funded by the National Institutes of Health, my lab has further the genetic and molecular characterization of Meiotic Silencing.

The general aim of this proposal is to speed the rate of discovery of natural products through development of genome and synthetic biology. I am specially qualified to work on this area for several reasons: I am a fungal molecular geneticist that has been trained in both asexual and sexual aspects of fungal development, stages of the life cycle that closely correlate with secondary metabolites production. I am a natural engineer that had to overcome experimental roadblocks by designing and implementing molecular and genetic technologies not existent at the time, to study meiotic silencing, a genetic phenomenon I discovered. I am a geneticist that understanding the need for a global "Systems" view of genetics resurrected a long passion I have with computers and acquired substantial expertise in the areas of Genomics, Bioinformatics and Computational Biology. I started teaching Genomics >12 years ago, well before Genomics textbooks were available, and currently teach Genomics, Computational Genomics and Digital Biology, all at the graduate and undergraduate level. I currently am the Director of the Laboratory for Genome Analysis at Texas A&M, a unit whose objective is to bring Bioinformatics and Computational Biology expertise to the campus community. I coordinate the campus-wide training of scientists in these areas. My understanding of Molecular Biology, Genetics, Genomics and computers has forced me to look at Biology from a highly modular point of view. As a result, I am a strong believer that the combination of genetics, genomics with synthetic biology will revolutionize Biology. B. Positions and Honors Positions and Employment ACADEMIC/RESEARCH POSITIONS TITLE INSTITUTION AND LOCATION YEAR(s) Researcher II Department of Genetic Engineering. National Center for Genetic Resources and

Biotechnology (CENARGEN-EMBRAPA). Brasília, D. F., Brazil 1983-1986

Assistant Department of Biology. Texas A&M University. College Station, Texas, USA 1997-2004

Program Director/Principal Investigator (Last, First, Middle): ARAMAYO, Rodolfo

Professor Associate Professor

Department of Biology. Texas A&M University. College Station, Texas, USA 2004-present

C. Selected Peer-reviewed Publications

Most relevant to the current application 1. Aramayo, R. and E.U. Selker, Neurospora crassa, a Model System for Epigenetics Research, inEpigenetics, C.D. Allis, et al., Editors. 2013, Cold Spring Harbor Laboratory Press.2. Lee, D.W., et al., A cytosine methyltransferase homologue is essential for sexual development inAspergillus nidulans. PLoS ONE, 2008. 3(6): p. e2531.3. Hu, J.C., et al., The emerging world of wikis. Science, 2008. 320(5881): p. 1289-90.4. Borkovich, K.A., et al., Lessons from the genome sequence of Neurospora crassa: tracing the path fromgenomic blueprint to multicellular organism. Microbiology and Molecular Biology Reviews : MMBR, 2004.68(1): p. 1-108, table of contents.5. Lee, D.W., J.R. Haag, and R. Aramayo, Construction of strains for rapid homokaryon purification afterintegration of constructs at the histidine-3 (his-3) locus of Neurospora crassa. Current Genetics, 2003. 43(1): p.17-23.6. Haag, J.R., D.W. Lee, and R. Aramayo, A GATEWAY™ destination vector for high-throughput constructionof Neurospora crassa histidine-3 gene replacement plasmids. Fungal Genetics Newsletter, 2003. 50: p. 6-8.7. Haag, J.R. and R. Aramayo, Construction of a his-3 integration vector capable of performing GATEWAYrecombinational cloning for high-throughput analysis of Neurospora crassa. Fungal Genetics Newsletter, 2003.50: p. 6-8.8. Pratt, R.J. and R. Aramayo, Improving the efficiency of gene replacements in Neurospora crassa: a firststep towards a large-scale functional genomics project. Fungal genetics and biology : FG & B, 2002. 37(1): p.56-71.9. Aramayo, R. and J.W. Bennet, The importance of fungal genomics. American Society for Microbiology(ASM) News, 1997. 63(4): p. 176-177.10. Aramayo, R. and R.L. Metzenberg, Gene replacements at the his-3 locus of Neurospora crassa. FungalGenetics Newsletter, 1996. 43: p. 9-13.11. Aramayo, R., T.H. Adams, and W.E. Timberlake, A large cluster of highly expressed genes is dispensablefor growth and development in Aspergillus nidulans. Genetics, 1989. 122: p. 65-71.

D. Research SupportOngoing Research Support

SOURCE: College of Science/Department of Biology TITLE: Implementation of a Galaxy Server to Enhance and expand

Computational Genomics at Texas A&M University PRINCIPAL INVESTIGATOR: Dr. Rodolfo Aramayo, Dr. Tom McKnight, Dr. Alan Pepper

SOURCE: Tier One Program (TOP)/Activity 2 grant TITLE: Comparative genomics of endosymbiotic bacteria (genus Spiroplasma)

associated with Drosophila flies PRINCIPAL INVESTIGATOR: Dr. Mariana Mateos, Dr. Rodolfo Aramayo

Completed Research Support

SOURCE: National Institutes of Health TITLE: Genetics and Molecular Study of Meiotic Trans-sensing and Meiotic

Silencing PRINCIPAL INVESTIGATOR: Dr. Rodolfo Aramayo NUMBER: R01-GM58770 PERIOD: 01/01/1999 to 12/31/2011

Giridhar Athrey ASSISTANT PROFESSOR OF GENOMICS

DEPT. OF POULTRY SCIENCE ● 2472 TAMU ● TEXAS A&M UNIVERSITY COLLEGE STATION ● TX 77843 ● USA

Office: 979-845-2994, Mobile: 337-849-3244 ● [email protected] www.giriathrey.com

A P P O I N T M E N T S

January 2015-Present Assistant Professor of Genomics Department of Poultry Science Texas A&M University

2010-2014 Postdoctoral Research Associate Texas A&M University (Uncovering the genetic basis of anthropophily in malaria vector mosquitoes, with Dr. Michel A Slotman)

July-Dec 2010 Visiting Postdoctoral Associate Wageningen University, Netherlands (Uncovering the genetic basis of anthropophily in malaria vector mosquitoes, working with Prof. Willem Takken)

2000-2001 Ecological Research Coordinator, SEEK Foundation, India (Organized environmental outreach for middle school students)

1998-2001 Founder and Research Coordinator, Eco Logic Foundation, India (Ecological research and outreach)

E D U C AT I O N

2009 Ph.D. Evolutionary and Environmental Biology Birds in space & time: patterns and processes of spatiotemporal genetics in two endangered songbirds. Department of Biology, University of Louisiana at Lafayette Supervisor: Prof. Paul L. Leberg

2004 M.S. BiologyEffects of selection for resistance to cadmium on genetic variation in the least killifish,Heterandria formosa.Department of Biology, University of Louisiana at LafayetteSupervisor: Dr. Paul L. Klerks

2001 B.Sc. Honours with Gold Medal for Honours Project(Microbiology, Chemistry, Botany, with Honours in Genetics)Epidemiology of the mysterious Handigodu Syndrome & Epidemiology of the KyasanurForest Disease.Bangalore University, Bangalore, India

1995 Diploma in Computer Programming NICE Institute, Bangalore, India

R E S E A R C H F O C I

☉ Genomics of complex quantitative traits ☉ Adaptation in disease vectors

☉ Functional genomics

L I S T O F P U B L I C AT I O N S

publications in peer-reviewed scientific journals

2015

27. Athrey G, Lance RF and Leberg PL, Using genealogical mapping to quantify dispersal distances inthe neotropical songbird, the Black-capped Vireo. PLoS One.

2014

26. Hodges TK, Athrey G, Cosme L, Takken W, Slotman MA. Differnetial expression of olfactory genesin the antennae and maxillary palps between the anthropophilic Anopheles gambiae & the zoophilicAnopheles quadriannulatus,. BMC Genomics

2013

25. Walter ST, Carloss M, Athrey G, Hess T and Leberg PL. Influences of brown pelican demography onpopulation structure and colony size, In Press, The Condor.

24. Hodges TK☯, Athrey G☯, Deitz K, Overgaard H, Matias A, Caccone A, Slotman MA. Largefluctuation in effective populations of malaria vectors during vector control cycle. EvolutionaryApplications DOI: 10.1111/eva.12094.

23. Walter ST, Carloss M, Athrey G, Hess T and Leberg PL. Brown Pelican Colony Initiation Attempts:Translocations and Decoys. Waterbirds 36(1): 53-62.

2012

22. Athrey, G, Hodges TK, Reddy MR, Overgaard HJ, Matias A, Abaga S, Caccone A, Slotman MA.Vector control has a large impact on the effective population size of Malaria mosquitoes. PLoS Genetics,8(12): e1003097.

21. Deitz KC, Athrey G, Reddy MR, Overgaard HJ, Abrahan Arnez, Moises Atue, Simon Abaga,Adalgisa Caccone, Michel A. Slotman. Genetic isolation within the malaria mosquito Anopheles melas.Molecular Ecology, 21(18): 4498-4513.

20. Athrey G, Lance RF and Leberg PL. How far is too close? Restricted, sex-biased dispersal in theblack-capped vireo, Molecular Ecology, 21(17): 4359-4370.

19. Athrey, G, Barr KR, Lance RF and Leberg PL. Birds in space & time: Genetic changesaccompanying anthropogenic habitat fragmentation in the endangered black-capped vireo (Vireoatricapilla), Evolutionary Applications, 5(7): 540-55.

http://onlinelibrary.wiley.com/doi/10.1111/eva.12094/full

2011

18. Barr KR, Athrey G, Lindsay DL, Lance RF, Hayden T, Tweddale S and Leberg PL. Missing the forestfor the gene trees: Conservation genetics is more than identification of distinct population segments. TheAuk, 128(4): 798-794.

17. Athrey G, Lindsay DL, Lance RF and Leberg PL. Crumbling Diversity: A century of genetic declinein an endangered songbird, Conservation Genetics, 12: 1345-1355.

2010

16. Leberg PL, Athrey G, Barr KR, Lindsay DL, and Lance RF. Implications of landscape alteration forthe conservation of genetic diversity of endangered species. In "Molecular insights into natural resourceconservation and management" (J.A. DeWoody, J.W. Bickham, C. Michler, K. Nichols, O.E. Rhodes, andK. Woeste, eds.), Cambridge University Press.

2009 and prior

15. Fike JA, Athrey G, Bowman R, Leberg PL, and Rhodes Jr., OE. Development of 25 polymorphicmicrosatellite markers for the red-cockaded woodpecker (Picoides borealis). Conservation Genetics,(2009) 10:1021-1023

14. Barr KR, Lindsay DL, Athrey G, Lance RF, Hayden T, Tweddale S and Leberg PL. 2008. Populationstructure in an endangered songbird: maintenance of genetic differentiation despite high vagility andsignificant population recovery. Molecular Ecology, (2008) 17: 3628-3639.

13. Athrey G, Leberg PL, and Klerks PL. Laboratory culturing and selection reduce genetic variation inthe least killifish, Heterandria formosa. Environmental Toxicology and Chemistry. (2007) 9(26):1916-1922

published proceedings and thesis

12. Deitz KC, Athrey G et al., (2014) Genome wide isolation within the west-African malaria vectorAnopheles melas. American Journal of Tropical Medicine and Hygiene. 91(5s).

11. Athrey G et al., (2014) Molecular adaptation to human hosts in the malaria mosquitoes Anophelesgambiae. American Journal of Tropical Medicine and Hygiene. 91(5s).

10. Athrey G et al., (2013) The impacts of vector control on the effective population size of malariamosquitoes. American Journal of Tropical Medicine and Hygiene. 89(5s).

9. Athrey G et al., (2013) The genetic basis of human host choice in the malaria vector Anophelesgambiae. American Journal of Tropical Medicine and Hygiene. 89(5s).

8. Athrey G et al., (2012) The genetic basis of adaptation to human hosts in the malaria vector Anophelesgambiae. American Journal of Tropical Medicine and Hygiene. 87(6s).

7. Hodges TK, Athrey G et al., (2012) The expression of olfaction genes in Anopheles gambiae inrelation to human host preference. American Journal of Tropical Medicine and Hygiene. 87(5s).

6. Athrey G et al., (2011) The impacts of anti-vector interventions on effective population sizes ofAfrican malaria vectors. American Journal of Tropical Medicine and Hygiene. 85(4): 280.

5. Athrey G et al., (2010) The molecular evolution of olfaction genes in the Anopheles gambiae complex.American Journal of Tropical Medicine and Hygiene. 83(5): 230-230.

4. Athrey G. (2009) Birds in Time & Space: Patterns and processes of spatiotemporal genetics in twoendangered songbirds. Doctoral Dissertation, University of Louisiana at Lafayette.

3. Athrey G. (2004) Effects of selection for resistance to cadmium on genetic variation in the leastKillifish Heterandria formosa. University of Louisiana at Lafayette.

2. Athrey G. (2001) A dermatoglyphic study of the mysterious Handigodu Syndrome. St. JosephsCollege, Bangalore University.

1. Athrey G. (2000). Epidemiology of Kyasanur Forest Disease: A zoonotic hemorrhagic fever.Bangalore University.

publications in preparation

Athrey G, Hodges TK, Cosme L, Takken W and Slotman MA. The genetic basis of adaptation to human hosts in the malaria vector Anopheles gambiae

Muhia, DM ☯, Athrey, G ☯, Kamau, L, Shililu, J, Bayoh, N, Slotman, MA, Gimnig, J and Walker, E. Population genetic structure of Anopheles gambiae s.s and Anopheles arabiensis in Western Kenya after long term use of Insecticide Treated bed Nets

Athrey G, Barr KR, Lance RF and Leberg PL; Nets, relatives and randomness: on the likelihood of non-randomly capturing relatives in targeted mist netting

☯ equal contribution

BIOGRAPHICAL SKETCH

NAME Judith M. Ball


eRA COMMONS USER NAME Jball EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION DEGREE (if applicable) YEAR(s) FIELD OF STUDY

Southeaster Louisiana University, Hammond, LA B.S. 1974 Med. Tech and Chem. Louisiana State University, Baton Rouge, LA Ph.D. 1990 Biochemistry Univ. of Pittsburgh School of Medicine, Pittsburgh, PA Postdoc 1990-1992 Biochemistry

Univ of Alabama at Birmingham, Birmingham, AL Postdoc 1992-1994 Microbiology

Baylor College of Medicine, Houston, TX Postdoc/ Research Associate

1994-1997 Virology

A. Positions and HonorsPositions and Employment1975 - 1981 Medical Technologist (ASCP), Baton Rouge General Hospital, Dept. of Pathology, Baton

Rouge, LA. 1981 - 1984 Research Associate III, State Diagnostic Virology Laboratory, Louisiana State Univ., Baton

Rouge, LA. 1997 - 2002: Assistant Professor, Dept. of Pathobiology, Texas A&M University, College Station, TX. 1997 – Present Graduate Faculty Member, Texas A&M University 1997 – Present Director, Peptide Core Facility 1998 - 2002: Assistant Professor, Joint appointment, Dept. of Molecular and Cellular Medicine, Texas Health

Science Center, Texas A&M University, College Station, TX. 1998 – Present: Director, Peptide Synthesis Core Facility, Texas A&M University. 2000 – Present: Full member and officer, Interdisciplinary Faculty of Virology, Texas A&M University, College

Station, TX. 2001 – Present: Full member, Interdisciplinary Faculty of Toxicology, Texas A&M University, College Station, TX. 2002 – Present Associate Professor, Dept. of Pathobiology, Texas A&M University, College Station, TX. 2002 – Present Associate Professor, Joint appointment, Dept. of Molecular and Cellular Medicine, Texas Health

Science Center, Texas A&M University, College Station, TX. 2002 – Present Faculty of Biotechnology, member and executive committee 2003 – 2006 Graduate Advisor, Department of Pathobiology, Texas A&M University, College Station, TX. 2003 – Present Member, Center for Microencapsulation & Drug Delivery, Texas A&M University. 2005 – 2007 Member, Center for Environmental and Rural Health, Texas A&M University.

Other Experience and Honors 1991-1993 Postdoctoral fellowship, Training Grant No. AI 07150-13; “Basic Mechanisms in Virology”,

University of Alabama at Birmingham 1997 Recipient of the Dr. Chris Noonan Award, Molecular Virology Division, Baylor College of Medicine 1998 Texas A&M University Nominee for the David and Lucile Packard Fellowship 1998 Texas A&M University Nominee for the Searle Scholar Program 1999 University Council of Principle Investigators, Texas A&M University, College Station, TX. 1999 CVM Nominee, Montague Scholars Teaching Award, Texas A&M University 2001 Office of Scientific Quality Control Panel, USDA, ARS, NP103 Animal Health – Virology & Prion Disease 2012 TAMU Writing Assessment Project 2012-2014 TAMU AgriLife Leadership Program 2012-2015 Biotechnology Executive Committee 2014 Named as Undergraduate Research Scholar Mentor

B. Selected peer-reviewed publicationsBall, J.M., Swaggerty, CL, Pei, CL, Cox, VW, Lim, W-S, Xu, X, Payne, SL. (2005) Surface unit glycoprotein

of equine infectious anemia virus exhibits signaling and exterotoxic activity. Virology 333:132-144. Parr, R. D., S. M. Storey, D. M. Mitchell, A. L. McIntosh, M. Zhou, K. D. Mir, and Ball, J.M. (2006). The

rotavirus enterotoxin, NSP4, directly interacts with the caveolae structural protein, caveolin-1. J. Virol. 80:2842-54.

Gallegos, A.M., Storey, S.M., Kier, A.B., Schroeder, F., and Ball, J.M. (2006). Structure and cholesterol dynamics of caveolae/raft and non-raft plasma membrane domains. Biochem 45: 12100-12116.

Schroeder, F., Atshaves, B.P., McIntosh, A.L., Gallegos, A.M., Storey, S.S., Parr, R.D., Jefferson, J.R., Ball, J.M., Kier, A.B. (2007) Sterol carrier protein-2: New roles in regulating lipid rafts and signaling.Biochemica et Biophysica Acta 1771:700-718.

Mir, K. Parr, R.D., Schroeder, F., and Ball, J.M. (2007). Rotavirus NSP4 Binds Both the Amino- and Carboxyl- Termini of Caveolin-1.Virus Research 126:106-11

Storey, S.M., Schroeder, F., and Ball, J.M. (2007). Full-length, glycosylated NSP4 is localized to plasma membrane caveolae by a novel raft isolation technique. J. Virol. 81:5472-5483.

Parr, R.A., Martin, G., Schroeder, M., Kier, A., Schroeder, F., and Ball, J.M. (2007). A new N-terminal Recognition Domain in Caveolin-1 Interacts with Sterol Carrier Protein-2 (SCP-2). Biochem 46:8301-8314

Atshaves, B.P., McIntosh, A.L., Landrock, D., Payne, H.R., Mackie, J.T., Maeda, N., Ball, J.M., Schroeder, F., and Kier, A.B. (2007). Effect of SCP-x gene ablation on branched-chain fatty acid metabolism. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G939-G951.

Storey, S.M., Gallegos, A.M., Atshaves, B.P., McIntosh, A.L., Martin, G.G., Parr, R.D., Landrock, K., Kier, A.B., Ball, J.M., and Schroeder, F. (2007). Selective cholesterol dynamics between lipoproteins and caveolae/lipid rafts. Biochem. 46:13891-13906.

Gallegos, A.M., Atshaves, B.P., McIntosh, A.L., Storey, S.M., Ball, J.M., Kier, A.B., and Schroeder, F. (2008). Membrane Domain Distributions: Analysis of Fluorescence Sterol Exchange Kinetics. Current Analytical Chem., 4:1-7.

Martin, G.G., Hostetler, H.A., Tichy, S.E., Russell, D.H., Berg, J.M., Woldegiorgis, G., Spencer, T.A., Ball, J.M., Kier, A.B., and Schroeder, F. (2008) Structure and function of the sterol carrier protein-2 (SCP-2) N-terminal pre-sequence. Biochem. 47:5915-5934.

Li, X., Mertens-Talcott, S.U., Zhang, S., Kim, K., Ball, J., Safe, S. (2010) MicroRNA-27Aa indirectly regulates Estrogen receptor alpha expression and hormone responsiveness in MCF-7 breast cancer cells. Endocrinology 151:2462-2473.

Gibbons, T.F., Storey, S.M., Williams, C.V., McIntosh, A., Mitchel, D., Parr, R., Schroeder, M., Schroeder, F., and Ball, J.M. (2011) Rotavirus NSP4: Cell type-dependent transport kinetics to the exofacial plasma membrane and release from intact infected cells. Virology Journal 8:278-297.

Schroeder, M.E., Hostetler, H.A., Schroeder, F., and Ball, J.M. (2012) The enterotoxic peptide and the caveolin-1 binding domain of the rotavirus non-structural protein 4 (NSP4) binds cholesterol. Journal of Amino Acids 2012:1-16.

Hoffmann, A.R., Welsh, C.J., Varner, P.W., de la Concha-Bermejillo, A., Ball, J.M., Ambrus, A., and Edwards, J.F. (2012) Identification of the target cells and sequence of infection during experimental infection of ovine fetuses with Cache Valley virus. Journal of Virology 86:4793-4800.

Ball. JM, Schroeder, M.D., Williams, C.V., Schroeder, M.E., and Parr, R.D. (2013) Mutational analysis of the rotavirus NSP4 enterotoxic domain that binds to caveolin-1. Virology Journal 10:336-349.

Yakshe, K., Franklin, Z., Ball, J.M. (2015) Rotaviruses: Extraction and Isolation of RNA, Reassortant Strains, and NSP4 Protein, Current protocols in Microbiology, In press.

Ball. JM, Medina-Boliver,F., Defrates, KD, Hambleton, E., Hulburt, ME, Napo-Olazabal, L., Atwill, RI, Gbai, P, and Parr, RD (2015) Investigation of stilbenoids as potential therapeutic agents for rotavirus infections, nn preparation.

BIOGRAPHICAL SKETCH NAME

SAKHILA K. BANU, MS, MPhil, PhD., POSITION TITLE

Assistant Professor eRA Commons user Name SKBANU

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION DEGREE (if applicable)

YEAR FIELD OF STUDY

Madurai Kamaraj University, India BS MS

1988 1991

Biology Biology

University of Madras, India MPhil 1993 Endocrinology

University of Madras, India PhD 2002 Endocrinology Laval University, Canada Post doc I 2003 Reproductive Endocrinology University of Montreal, Canada Post doc II 2004 Endocrine Oncology

A: RESEARCH AND/OR PROFESSIONAL EXPERIENCE: I started my appointment in the College of Veterinary Medicine at Texas A&M University as a Research Assistant Professor in 2005, and was promoted to an Assistant Professor (Tenure track) in Jan 2012. In the past 10 years I have had 25 publications in peer reviewed journals. I have been awarded 7 grants (PI in 5 grants and Co-PI in two USDA grant) including NIH/NIEHS R03 and R21. My interdisciplinary background in Endocrinology and Molecular Reproductive Biology and Toxicology has enabled me to develop extensive expertise in the effect of heavy-metal endocrine disruptors on reproductive failures in women and developmental defects in children. My main research focus has been on the effect of hexavalent chromium, CrVI, on female reproductive function, premature ovarian failure and fetal development. Novel findings from my laboratory at Texas A&M University supported by NIH R03 (ES016605-01A21) and R21 awards (ES020561-01) laid the ground work for the proposed research by revealing that gestational exposure to CrVI advances oocyte nest break down and induces premature ovarian failure (POF) in F1 female offspring (Developmental Biology, 2014). Our latest finding has identified a novel role for X-prolyl aminopeptidase (Xpnpep) 2, a POF marker gene in women, in CrVI-induced adverse effects on germ cell nest breakdown and follicle development (BOR, 2015). Our recent studies also identified oxidative stress pathway as one of the major mechanisms that lead to increased follicle atresia in F1 offspring (Free Radical Biology of Medicine, 2013; Biology of Reproduction, 2014). Thus, my lab is one of the leading labs in the nation to identify Cr-induced female reproductive toxicology. My current focus and long-term goals are to unravel the molecular and cellular mechanisms of gestational and lactational exposure to heavy-metal endocrine disruptors on reproductive and developmental failures in subsequent generations.

B. POSITIONS & HONORS:Positions: 2000-2001: Research Assistant, Reproductive Toxicology, Dept of Endocrinology, Univ. of Madras, Chennai, India. 2001-2003: Post Doctoral Fellowship -I, Reproductive Molecular Endocrinology, Dept of Obstetrics & Gynecology, CHUL, Laval University, Quebec, Canada. 2003 -2004 : Post Doctoral Fellowship- II, Molecular Oncology, Dept. Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, St. Hyacinthe, J2S 7C6, Quebec, Canada. 2005-2008 April: Research Assistant Professor, Endocrine/Reproductive Toxicology & Oncology Dept of Integrative Biosciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas 77843, USA. 2008 May-present: Clinical Assistant Professor, Endocrine/Reproductive Toxicology & Oncology, Dept of Integrative Biosciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas 77843, USA. 2012 January-present: Assistant Professor, Endocrine/Reproductive Toxicology, Dept of Integrative Biosciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas 77843, USA.

Membership in scientific/professional Societies: Active life member (1994 –till date), Society for Reproductive Biology and Comparative Endocrinology; Member (20001-till date), Society for Study of Reproduction; External examiner, University of Madras, PhD theses (2006- till date). Honors:

Name of the Awards Type/Organization Year Honorary Visiting Professor University of Madras, India 2009 FY-08 Program Development Award VIBS, Texas A&M University 2008 Winn Research Award Winn Feline Foundation, USA 2008 Canine Health Foundation ACORNs Grant Award, USA 2007 FY-07 Program Development Award VIBS, Texas A&M University 2007 AAFP- First Grant Award American Association of Feline Practitioners, USA 2006 SSR Trainee Travel Award Society for the Study of Reproduction, USA. 2003 CIHR Merit Award CIHR, Govt. of Canada. 2003 Larry Ewing Memorial Award Society for the Study of Reproduction, USA. 2003 USDA-NRI Merit Award. USDA-NRI, USA 2002 CIHR Merit Award- CHIR, Govt. of Canada. 2002 SSR Trainee Travel Award Society for the Study of Reproduction, USA. 2002 Senior Research Fellowship Council of Scientific & Industrial Research, Govt of India. 1997-2000 Senior Research Fellowship Lady Tata Memorial Trust & Hospitals, Mumbai, India. 1993-1995

C. Selected Peer-reviewed Publications: (From 32; PubMed search: Banu SK or Banu KS).1. Banu SK, Stanley JA, Sivakumar KK, Arosh JA, Barhoumi R & Burghardt RC. Identifying a novel role for Xaa-

Pro aminopeptidase (XPNPEP)-2 in CrVI-induced disruption of germ cell nest breakdown and follicledevelopment. Biol Reprod. 2015 Jan 7. [Epub ahead of print] PMID: 25568306; Grant support, NIH (Banu, PI).

2. Stanley JA, Sivakumar KK, Arosh JA, Burghardt RC, Banu SK. Edaravone Mitigates Hexavalent Chromium-Induced Oxidative Stress and Depletion of Antioxidant Enzymes while Estrogen Restores Antioxidant Enzymesin the Ovary in F1 Offspring. Biol Reprod. 2014, May 7. [Epub ahead of print] PubMed PMID: 24804965.

3. Sivakumar KK, Stanley JA, Arosh JA, Pepling ME, Burghardt RC, Banu SK. Prenatal exposure to chromiuminduces early reproductive senescence by increasing germ cell apoptosis and advancing germ cell cystbreakdown in the F1 offspring. Dev Biol. 2014, 388:22-34. PMID: 24530425; PMCID: PMC3991725.

4. Stanley JA, Sivakumar KK, Nithy TK, Arosh JA, Hoyer PB, Burghardt RC & Banu SK. Postnatal exposure tochromium through mother's milk accelerates follicular atresia in F1 offspring through increased oxidative stressand depletion of antioxidant enzymes. Free Radical Biology & Medicine, 2013; 61C: 179-196.

5. Banu SK, Stanley JA, Lee J, Stephen SD, Arosh JA, Hoyer PB, Burghardt RC. Hexavalent chromium-inducedapoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members, ERK and p53.Toxicol Appl Pharmacol, 2011; 251: 253-66. PMID: 21262251. PMC3131794.

6. Sakhila K. Banu, 2013. Heavy metals and the Ovary. In Ovarian Toxicology, ed. P.B.Hoyer. Taylor & Francis.7. Lee J, Banu SK, Rodriguez R, Starzinski-Powitz A, Arosh JA. Selective blockade of prostaglandin E2 receptors

EP2 and EP4 signaling inhibits proliferation of human endometriotic epithelial cells and stromal cells throughdistinct cell cycle arrest. Fertil Steril. 2010; 93:2498-506. PMID: 20207353.

8. Banu SK, Lee J, Satterfield MC, Spencer TE, Bazer FW and Arosh JA. Molecular cloning and characterizationof prostaglandin transporter in ovine endometrium: Evidence for multiple cell signaling cross-talk on transport ofprostaglandin F2 alpha. Endocrinology 2008 ; 149: 219-31.

9. Banu SK, Arosh JA, Chapdelaine P and Fortier MA. Expression of prostaglandin transporter PGT in uterus andfetal membranes during pregnancy in cattle. Biol Reprod 2005, 73: 230-236.

10. Arosh JA*, Banu SK*, Chapdelaine P, Kimmins S, MacLaren LA and Fortier MA. Effect of interferon-tau onprostaglandin biosynthesis, transport, and signaling at the time of maternal recognition of pregnancy in cattle:evidence of polycrine actions of prostaglandin E2.Endocrinology. 2004, 145: 5280-5293.(*equal contribution)

11. Banu SK, Arosh JA, Chapdelaine P and Fortier MA. Molecular cloning and spatio-temporal expression of theprostaglandin transporter-PGT: A basis for the action of prostaglandins in the bovine reproductive system. PNAS2003, 11747-11752.

D. Ongoing Research Support:USDA (2011-03140) 09/01/2013 to 08/31/2017 $499,986 The Role of Intraluteal prostaglandins in luteolysis and luteal protection in sheep. Role: Co-Investigator The goal of the project is to determine the factors regulating intraluteal PGF2a and PGE2 biosynthesis and signaling during luteolysis and establishment of pregnancy using sheep as a ruminant model.

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Lee%20J%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Banu%20SK%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Rodriguez%20R%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Starzinski-Powitz%20A%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Arosh%20JA%22%5BAuthor%5D

javascript:AL_get(this,%20'jour',%20'Fertil%20Steril.');

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors.


NAME BERGHMAN, Luc R.


eRA COMMONS USER NAME berghman EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)


University of Leuven, Belgium MSc 1982 Zoology University of Leuven, Belgium PhD 1988 Zoology University of Leuven, Belgium Postdoc 1988-1994 Zoology

A. Positions and Honors

1988: Postdoctoral Research Fellow, National Fund for Scientific Research, Belgium 1994: Senior Research Associate, National Fund for Scientific Research, Belgium 1994: Assistant Professor, Department of Zoology, University of Leuven (partim) 06/1998 – 08/2005: Assistant Professor, Department of Poultry Science, TAMU 09/1998 – 08/2005: Assistant Professor, Department of Veterinary Pathobiology, TAMU 09/2005 – present: Associate Professor, Depts. of Poultry Science and Vet. Pathobiology Poultry Science, Associate Editor. B. Selected peer-reviewed publications (selected from a total of 104)

The use of monoclonal antibodies to isolate antigens by immunoaffinity chromatography. Vandesande, F. and Berghman L.R. (1988) in: Molecular neuroanatomy. Techniques in behavioural and neural sciences.Ch. 23 pp 375-387 (Eds. Van Leeuwen, F.W., Buijs, R.M. and Pool, C.W.) Elsevier. One step purification of chicken growth hormone from a crude pituitary extract by use of a monoclonal immunoadsorbent. Berghman, L.R., Van Beeumen, J., Decuypere, E., Kühn, E.R. and Vandesande, F. (1988). Journal of Endocrinology 118, 381-387. Development of a novel screening device allowing the immunocytochemical screening of numerous culture supernatants during hybridoma production. Berghman, L.R., Horsten, G. and Vandesande, F. (1989). Journal of Immunological Methods. 125 (1-2): 225-232. Immunocytochemistry and immunoblotting of avian prolactins using polyclonal and monoclonal antibodies towards a synthetic fragment of chicken prolactin. Berghman, L.R., Grauwels, L., Vanhamme, L., Proudman, J.A., Foidart,A., Balthazart, J. and Vandesande, F. (1992). General and Comparative Endocrinology 85, 346-357. Immunocytochemical demonstration of chicken hypophyseal thyrotropes and development of a radioimmunological indicator for chicken TSH using monoclonal and polyclonal homologous antibodies in a subtractive strategy. Berghman, L.R., Darras, V.M., Chiasson, R.B., Decuypere, E., Kühn, E.R., Buyse, J. and Vandesande, F. (1993). General and Comparative Endocrinology 92, 189-200. A simple method for the immunocytochemical processing of large numbers of floating cryosections, applied to the screening for monoclonal antibodies. Berghman, L.R., Grauwels, L., Vanhamme, L. and F. Vandesande (1994). Journal of Immunological Methods 168(2): 197-202. One-step immunoaffinity purification and partial characterization of hypophyseal growth hormone from the African catfish, Clarias gariepinus (Burchell). Berghman, L.R., Lescroart, O., Roelants, I., Ollevier, F., Kühn, E.R., Verhaert, P.D., De Loof, A. and Vandesande, F. (1996). Comp. Physiol. Biochem. B; 113(4): 773-780. Characterisation of chicken monocytes, macrophages and interdigitating cells by the monoclonal antibody KUL01. Mast J, Goddeeris BM, Peeters K, Vandesande F, Berghman LR (1998) Vet Immunol Immunopathol Feb 27;61(2-4):343-357.

The molecular characterization of chicken pituitary N-terminal pro-opiomelanocortin (POMC): affinity isolation of the isoforms and cloning of the POMC cDNA. Berghman, L.R., Devreese, B., Verhaert, P., Gerets, H., Arckens, L., Vanden Broeck, J., van Beeumen, J., Vaudry, H. and Vandesande, F. (1998) Mol Cell Endocrinol 25: 119-130 Effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on cAMP formation and growth hormone release from chicken anterior pituitary cells. Peeters K, Langouche L, Vandesande F, Darras VM, Berghman LR (1998) Ann N Y Acad Sci 865:471-474 Immunohistochemical evidence that follicle-stimulating hormone and luteinizing hormone reside in separate cells in the chicken pituitary. Proudman, J. A., Vandesande, F. and Berghman, L. R. (1999). Biology of Reproduction 60: 1324-1328. Validation of a new antiserum directed towards the synthetic c-terminus of the fos protein in avian species: immunological, physiological and behavioral evidence. D'Hondt, E., Vermeiren, J., Peeters K., Balthazart J., Tlemçani O., Ball G. F., Duffy D. L., Vandesande F. and Berghman L. (1999). J Neurosci Methods 91: 31-45. The sequence and distribution of pro-opiomelanocortin (POMC) in the pituitary and the brain of the chicken (Gallus gallus) Gerets, H., Peeters, K., Vandesande, F. and Berghman, L.R. (2000). Journal of Comparitive Neurology 417; 250-262. Interferon regulatory factor two restricts expression of interferon-stimulated genes to the endometrial stroma and glandular epithelium of the ovine uterus. Biol Reprod. 65(4):1038-49.Choi Y, Johnson GA, Burghardt RC, Berghman LR, Joyce MM, Taylor KM, Stewart MD, Bazer FW, Spencer TE (2001). FSH- and LH-cells originate as separate cell populations and at different embryonic stages in the chicken embryo. N. Puebla-Osorio, J.A. Proudman, A.E. Compton, K.E. Clements, E. Decuypere, F. Vandesande, and L.R. Berghman (2002) Gen. Comp .Endocrinol. 127(3):242-248. Immunohistochemical localization of chromogranin A in turkey and chicken pituitary gonadotrophs and somatotrophs (2003). J. A. Proudman, S. Clerens, G. van den Bergh, W. Garrett, P. D. Verhaert, F. Vandesande, and L. R. Berghman. Gen Comp Endocrinol. 132(2):293-303. Immunohistochemical assessment of the neurosecretory cells of the chicken thymus using a novel monoclal antibody against avian chromogranin A. (2003). Oubre C.M.*, Zhang X.*, Clements*, K.E., Porter T.E. and Berghman L.R. Developmental and Comparative Immunology 28(4):337-45. The chicken pituitary expresses an ovoinhibitor-like protein in subpopulations of some, but not all, hormone-producing cell types. (2003). Oubre CM, D'Hondt E, Moore RW, Hargis BM, Berghman LR. Domest Anim Endocrinol. 25(4):389-97. Patterns of Fos-Like Immunoreactivity in the Brains of Parent Ring Doves (Streptopelia risoria) Given Tactile and Nontactile Exposure to Their Young. (2006) Buntin L, Berghman LR, Buntin JD. Behav Neurosci. Jun;120(3):651-64. Phage display selection and characterization of single-chain recombinant antibodies against Eimeria tenella sporozoites. Abi-Ghanem D, Waghela SD, Caldwell DJ, Danforth HD, Berghman LR. Vet Immunol Immunopathol. 2008 Jan 15;121(1-2):58-67. Production and characterization of agonistic monoclonal antibodies against chicken CD40. Chen CH, Abi-Ghanem D, Njongmeta L, Bray J, Mwangi W, Waghela SD, McReynolds JL, Ing NH, Berghman LR. Dev Comp Immunol. 2010 Nov;34(11):1139-43. Epub 2010 Jul 3. A chemifluorescent immunoassay for the determination of marinobufagenin in body fluids. Abi-Ghanem D, Lai X, Berghman LR, Horvat D, Li J, Romo D, Uddin MN, Kamano Y, Nogawa T, Xu JP, Pettit GR, Puschett JB. J Immunoassay Immunochem. 2011 Jan;32(1):31-46. Marinobufagenin levels in preeclamptic patients: a preliminary report. Agunanne E, Horvat D, Harrison R, Uddin MN, Jones R, Kuehl TJ, Abi-Ghanem D, Berghman LR, Lai X, Li J, Romo D, Puschett JB. Am J Perinatol. 2011 28(7):509-14. A nanobeads amplified QCM immunosensor for the detection of avian influenza virus H5N1. Li D, Wang J, Wang R, Li Y, Abi-Ghanem D, Berghman L, Hargis B, Lu H. Biosens Bioelectron. 2011 26(10):4146-54.

VICTORIA BUENGER, Ph.D. Clinical Professor

Department of Management Mays School of Business Texas A&M University

College Station, TX 77843 Email: [email protected]

Phone: 979-845-4851

EDUCATION

1990 Ph.D., Management, Texas A&M University 1983 M.A., History, Texas A&M University 1981 B.A., History, Texas A&M University, Magna Cum Laude

EXPERIENCE

2015-present Clinical Professor, Texas A&M University 2004-2015 Clinical Associate Professor, Texas A&M University 1994-2004 Visiting Assistant Professor, Texas A&M University 1990-1994 Assistant Professor, Owen Graduate School of Management, Vanderbilt University

UNIVERSITY TEACHING EXPERIENCE

Academic Service University Graduate Faculty University and Mays Business School Honors Faculty Joint Appointment, Biotechnology Professional Program

Undergraduate Teaching (courses)

Strategic Management Survey of Management Project Management

Graduate Teaching (courses)

Managing Projects Strategic Management Survey of Management Human Resources Information Systems

Graduate Academic Committees 2013 Sakshi Gupta—Masters Candidate in Biotechnology

Kathik Sankaranarayanan—Masters of Science Candidate in Industrial Engineering

2012 Dev Unnati—Masters Candidate in Biotechnology Sreeram M. Reddy—Masters Candidate in Biotechnology Eric Puls—Masters of Science Candidate in Civil Engineering Pallav Shah—Masters Candidate in Biotechnology

2011 Joshua Street—Masters of Arts Candidate in Communications Reuben D. Sequeira—Masters Candidate in Biotechnology Dilsher Dhillon—Masters Candidate in Biotechnology

2010 John David Lowderman—Masters Candidate in Biotechnology Joan Marie Scaparra—Masters Candidate in Biotechnology

2009 Suzanne Marie McElheny—Masters Candidate in Public Service and Administration Vidhi Sunil Danak—Masters of Science Candidate in Construction Management Oluwafunmike Owolabi—Masters Candidate in Biotechnology

2008 Amy Sanders—Masters of Arts Candidate in Communications Kenneth Justin Bull—Masters of Science Candidate in Kinesiology Laura Brown—Masters of Arts Candidate in Communications Daniel Aaron Cisneros—Masters of Engineering Candidate in Biomedical Engineering James Jerry—Masters of Education Candidate in Agricultural Education Deepthi Mikkili—Masters Candidate in Biotechnology Ashwin Mohan—Masters Candidate in Biotechnology Sreedevi Vijay Kumar—Masters Candidate in Biotechnology Kelly Mueller—Masters Candidate in Biotechnology Megan Leigh Buro—Masters of Science in Recreation Park & Tourism Science Huajun He—Masters Candidate in Biotechnology Yun-An Shen—Masters Candidate in Biotechnology Manoj Nagarajan Sunder—Masters of Science Candidate in Mechanical Engineering Gaurav Singh Sehra—Masters of Science Candidate in Civil Engineering Sachin Pingle—Masters of Engineering Candidate in Mechanical Engineering Vineet Bailur—Masters of Science Candidate in Construction Management

2007 Wan-Chi Yang—Masters of Science Candidate in Educational Human Resources Dev. Harshwardhan Banda—Masters Candidate in Biotechnology Mayur Gadhikar—Masters Candidate in Biotechnology Latoya Anderson—Masters of Engineering in Industrial Engineering

2006 Leslie Chavez—Masters of Public Service in the Bush School Carolyn Igwe—Masters of Public Service in the Bush School

REFEREED PUBLICATIONS

Buenger, V. and W.L. Buenger. Texas Merchant: Marvin Leonard & Fort Worth. College Station, Texas: Texas A&M University Press, 1998.

Buenger, V., R.L. Daft, E.J. Conlon, and J.S. Austin. "Competing Values in Organizations: Contextual Influences and Structural Consequences." Organizational Science, Vol. 7, No. 5 (September-October 1996).

CONFERENCE PRESENTATIONS

“The Role of Patient Advocates and Patient Advocacy Groups in Pediatric Cancer Research.” The Neuroblastoma and Medulloblastoma Translational Research Consortium Summit, Grand Rapids, Michigan, 2014.

"CAC2 and Barriers to Drug Development.” National Cancer Institute—Director’s Consumer Liaison Group, Bethesda, Maryland, 2014.

"Managing Research Projects: Tips, Lessons Learned, and Project Management 101." Academy of Management Meeting, HR Professional Development Workshop, 2013.

UNREFEREED PUBLICATIONS

Instructor's Case Notes to accompany M.A. Hitt, R.E. Hoskisson, and R.D. Ireland's Strategic Management: Competitiveness and Globalization. West Publishing Company, 1995.

Daft, R.L. and V. Buenger. "Hitching a Ride on a Fast Train to Nowhere: The Past and Future of Strategic Management Research." In James W. Fredrickson (ed.) Perspectives on Strategic Management. Cambridge, MA: Ballinger, 1990.

Buenger, V. and R.L. Daft. "The Puzzle of Paradox in Just-In-Time Manufacturing." In R.E. Quinn and K.S. Cameron (eds.) Paradox and Transformation: Toward a Theory of Change in Organization and Management. Cambridge, MA: Ballinger, 1988.

Numerous book reviews

UNIVERSITY SERVICE

Executive Committee—Biotechnology Professional Program, 2011-present Mays Undergraduate Curriculum and Assessment Committee, 2010-present “W” and “C” Course Working Group, 2010-2012 Mays Academy on Learning and Teaching (M.A.L.T.), 2011-present Departmental Representative–WEAVE Online, 2009-present Departmental Assessment Committee, 2009-present Departmental Committee, Not-for-Profit Track, 2012

Management Department, Library Representative, 2009-2012 Faculty Advisor, American Childhood Cancer Organization-TAMU, 2011-present Faculty Advisor, Team InCellerate Case Team, 2012 Faculty Advisor, United Campus Ministry in Aggieland, 2014-present

PROFESSIONAL ACTIVITIES

Personnel Psychology, Book Review Advisory Panel Academy of Management

Business Policy & Planning Division Organization & Management Theory Division Management History Division

Beta Gamma Sigma, National Business School Honor Society

NATIONAL AND INTERNATIONAL OUTREACH ACTIVITIES

Campaign Co-Lead, #StepUp media and social media campaign, a national cooperative project of the Alliance for Childhood Cancer and the Coalition Against Childhood Cancer, in progress

Project Shepherd, #SaveJosh media and social media campaign, March 2014* Advisor, All-Party Childhood Cancer Advocacy Coalition, London, UK, 2014 Co-Founder, President, Executive Committee, and Board Member—the Coalition Against

Childhood Cancer, 2013-present Consultant, Texas State Historical Association, Strategic and Operational Audit, 2013-2014 Expert Source, Childhood Cancer Awareness. “Towers Glow Gold in Honor of Childhood Cancer

Awareness, A Cause Close to Many Families, by Cassie Fambro. AL.com, September 27, 2013. http://blog.al.com/live/2013/09/towers_glow_gold_in_honor_of_c.html#incart_river

Team Member, STORM (Standardized Tumor Outcome Repository Management)—a multidisciplinary, multi-institutional research project addressing therapeutic interventions for childhood cancers, 2012

Team Member, STS—Soft Tissue Sarcoma Dream Team, 2012 Project Manager, Project Collaborate, Organizational Start Up, 2012-2013 Co-Lead/Advisor, Project Collaborate, Design Phase, 2011 Co-Moderator—National Childhood Cancer Branding Task Force, 2011 Unpaid Staff—Congressman Chet Edwards-Health Care Issues, Summer 2010

COMMUNITY OUTREACH ACTIVITIES

Co-Founder, Steering Committee, and Volunteer—Carter Creek After School Program, 2011-present Executive Committee and Board Member—Brazos Valley Hospice, 2010-present Board Member—Southwest Chapter, Children’s Neuroblastoma Cancer Foundation, 2008-present Executive Committee, Brazos Democrats, 2008-present Co-Founder, Treasurer, and Board Member, Brazos Interfaith Immigration Network, 2009-2013 Board of Directors, Brazos Youth Sports Foundation, 2010-2012 “You’re the TOPS” honoree—Pre-Natal Clinic, 2011

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.


NAME Burghardt, Robert C.

POSITION TITLE Professor, Veterinary Integrative Biosciences, Texas A&M University eRA COMMONS USER NAME

rburghardt EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)


University of Michigan, Ann Arbor, MI B.S. 1969 Zoology Wayne State University, Detroit, MI M.S. 1973 Biology Wayne State University, Detroit, MI Ph.D. 1976 Biology Harvard Medical School, Boston, MA Postdoc 1976-78 Reproductive Biology

A. Personal StatementThe Burghardt laboratory makes extensive use of non-invasive imaging technologies to investigate thephysiology of cells along with the analysis of the mechanisms by which a variety of biological responsemodifiers ranging from hormones and growth factors to chemotherapeutic agents and environmental chemicalsalter cellular signaling pathways and cellular homeostasis. Particular emphasis has been focused on real timevisualization of the in situ metabolism of polycyclic aromatic hydrocarbons using benzo[a]pyrene as a modelcompound to identify individual reactive metabolites and DNA adducts within in living cells along withintervention strategies that modulate PAH metabolism and/or reverse cellular injury. The laboratory is alsoinvolved in probe development and serves as an Advanced Imaging Facility Core for the NIEHS-supportedCenter for Translational Environmental Health Research to provide state-of-the-art imaging tools that can beused to visualize cell and tissue physiology in a homeostatic framework and in response to environmentalperturbations. Research in the laboratory has involved the participation of undergraduates, graduate andprofessional students and postdoctoral fellows including service on more than 255 Ph.D. and M.S. studentgraduate advisory committees. .

B. Positions and Honors1976 -1978 Ford Foundation Postdoctoral Fellow, Department of Anatomy and Laboratory of Human

Reproduction and Reproductive Biology, Harvard Medical School 1978 -1987 Assistant, Associate Professor, Department of Biology, Texas A&M University (TAMU) 1982 -1987 Director, Electron Microscopy Center, TAMU 1987 -1991 Associate Professor, Department of Veterinary Integrative Biosciences, TAMU 1987 - Director, Image Analysis Laboratory, College of Veterinary Medicine, TAMU 1991 - Professor, Department of Veterinary Integrative Biosciences, TAMU 2005 - 2010 Chair, Interdisciplinary Faculty of Toxicology 2010 - 2012 Chair, Interdisciplinary Faculty of Reproductive Biology 2013 - Associate Dean for Research and Graduate Studies, CVM, TAMU

Professional Activities: Associate Editor, Biology of Reproduction, 1992-95; Editorial Boards, Cells Tissues Organs, 2004-; Journal of Applied Toxicology, 2006-; Chair, Publications Committee, Society for the Study of Reproduction (SSR), 1996-99, 2005-07; Chair, Awards Committee, SSR, 2004-05; Director, SSR, 2000-03; Secretary, SSR, 2010-2013; Ad hoc reviewer: 48 different journals; Review committee service: Ad hoc reviews, NSF (Integrative Animal Biology, Signal Transduction and Regulation), NIH (HED-1, Metabolism Reproduction, NIEHS, NIH/NIGMS MBRS; Member, NIH/USDA PAR), USDA (Animal Reprod Efficiency), Wellcome Trust (Joint Infrastructure Fund, UK), Veterans Health Administration, Israel Science Foundation, Natural Sciences and Engineering Research Council of Canada, March of Dimes. Honors: Association of Former Students, Distinguished Teaching Award, 1995; College of Vet. Medicine, Wiley Distinguished Teaching Professorship 2000-03; Vice Chancellor's Award in Excellence for Team Research in Uterine Biology and Pregnancy, 2005; SSR Distinguished Service Award, 2010

C. Selected Peer-reviewed Publications (From 251 peer-reviewed publications)1. Parrish AR, G Chen, RC Burghardt, T Watanabe, C Morisseau, BD Hammock (2009) Attenuation of cisplatin

nephrotoxicity by an inhibitor of soluble epoxide hydrolase. Cell Biol Toxicol, 25:217-225.2. Han J, A Loudet, RB Mouneimne, RC Burghardt, K Burgess (2009) A ratiometric pH reporter for observing

protein-dye conjugates in living cells. J Am Chem Soc 131:1642-1643. PMC27207883. Chadalapaka G, I Jutooru, R Burghardt, S Safe (2010) Drugs that target specificity proteins downregulate

epidermal growth factor receptor in bladder cancer cells. Mol Cancer Res 8:739-750, PMC28726864. Jutooru I, G Chadalapaka, S Sreevalsan, P Lei, R Barhoumi, R Burghardt, S Safe (2010) Arsenic trioxide

downregulation of specificity protein (Sp) transcription factors in bladder cancer cells is dependent on reactiveoxygen species (ROS). Exp Cell Res 316:2174-2188. PMC2900380

5. Sivakumar KK, JA Stanley, JA Arosh, ME Pepling,RC Burghardt, SK Banu (2014) Prenatal exposure tochromium induces early reproductive senescence by increasing germ cell apoptosis and advancing germ cellcyst breakdown in the F1 offspring. Develop Biol 388:22-34. PMC3991725

6. Barhoumi R, Y Mouneimne, RS Chapkin, RC Burghardt (2014) Effects of fatty acids on benzo[a]pyrene uptakeand metabolism in human lung adenocarcinoma A549 cells. PLoS One9(3):e90908. doi:10.1371/journal.pone.0090908. PMC3961214

7. Jutooru I, AS Guthrie, G Chadalapaka, S Pathi, K Kim, R Burghardt, UH Jin (2014) Mechanism of action ofphenethylisothiocyanate and other ROS-inducing anticancer agents. Mol Cell Biol 34:2382-2395.

8. Stanley JA, KK Sivakumar, JA Arosh, RC Burghardt, SK Banu (2014) Edaravone mitigates CRVI-inducedoxidative stress and depletion of antioxidant enzymes while estrogen restores antioxidant enzymes in the ovaryin F1 offspring. Biol Reprod, 91(1):12, 1–12. PMID 24804965

9. Peña B, R Barhoumi, RC Burghardt, C Turro, KR Dunbar (2014) Confocal fluorescence microscopy studies of afluorophore-labeled dirhodium compound: visualizing metal-metal bonded molecules in lung cancer (A549) cells.J Am Chem Soc 136:7861-7864. PMC4063186

D. Research SupportOngoing Research SupportACTIVE5R01CA142697-02 (PI: Safe) 07/01/10 – 05/31/15 0.6 calendarNCIMolecular Mechanisms and Application of AH Receptor-MicroRNA InteractionsThe goal of these studies is to investigate the molecular mechanisms and potential clinical applications of MCDFand structurally-related SAhRMs for treatment of ER-negative breast cancer.Role: Co-Investigator

USDA 2013-00840 (PI: Arosh) 09/01/13 – 08/31/17 0.6 calendar The Role of Intraluteal Prostaglandins in Luteolysis and Luteal Protection in Sheep The objective is to determine the factors regulating intraluteal PGF2a and PGE2 biosynthesis and signaling during luteolysis and establishment of pregnancy using sheep as a ruminant model. Role: Collaborator

1R21HD071468-01A1 (PI: Johnson) 02/01/13 – 1/31/15 1.2 calendar Incorporation of Endothelial Progenitor Cells into Placental Vasculature. The objectives are to: Determine the intercellular signals that allow EPCs to incorporate into established vasculature; and determine whether EPCs incorporate into placental vascular networks pigs. Role: Co-Investigator

P30 ES023512-01, (PI: Walker) 02/01/14 – 1/31/17 1.2 calendar NIEHS Center for Translational Environmental Health Research The goal of the Center is to promote integrated translational research, and catalyze interdisciplinary research in human environmental health. The CTEHR Mission is to improve our understanding of environmental influences on human health by integrating basic, biomedical and engineering research across translational boundaries from the laboratory to the clinic and to the community and back. Role: Advanced Imaging Core Co-Director; Career Development Core Co-director

JAMES J. CAI

Work AddressVeterinary Integrative BiosciencesTexas A&M UniversityCollege Station, Texas 77843, [email protected]

PROFESSIONAL EXPERIENCE

Texas A&M University – Dept. of Vet. Integrative Biosciences, Faculty of Genetics 2011–presentAssistant Professor

EDUCATION

Postdoc, Evolutionary Population GenomicsStanford University (Dmitri Petrov Lab) 2006–2010

Ph.D., GenomicsUniversity of Hong Kong, Hong Kong 2002–2006

M.S., BiotechnologyUniversity of New South Wales, Sydney, Australia 1999–2001

B.S., General MedicineHenan Medical University, Zhengzhou, China 1991–1996

PEER-REVIEWED PUBLICATIONS

1. Yang E, Wang G, Yang J, Zhou B, Tian Y, Cai JJ∗ (2016) Epistasis and destabilizing mutationsshape gene expression variability in humans via distinct modes of action. Hum Mol Genet, Sep 20. pii:ddw314.

2. Brinkmeyer-Langford CL, Guan J, Ji G, Cai JJ∗ (2016) Aging shapes the population-mean and -dispersion of gene expression in human brains. Front Aging Neurosci, Aug 3;8:183.

3. Guan J, Yang E, Yang J, Zeng Y, Ji G, Cai JJ∗ (2016) Exploiting aberrant mRNA expression inautism for gene discovery and diagnosis. Hum Genet, 11(1):1-15.

4. Brinkmeyer-Langford C, Balog-Alvarez C, Cai JJ, Davis BW, Kornegay JN (2016) Genome-wideassociation study to identify potential genetic modifiers in a canine model for Duchenne musculardystrophy. BMC Genomics, Aug 22;17:665.

5. Zeng Y, Wang G, Yang E, Ji G, Brinkmeyer-Langford CL, Cai JJ∗ (2015) Aberrant gene expressionin humans. PLoS Genet, 11(1):e1004942.

6. Chacko N, Zhao Y, Yang E, Wang L, Cai JJ, Lin X (2015) LncRNA RZE1 controls cryptococcalmorphological transition. PLoS Genet, 11(11):e1005692.

7. Stafuzza NB, Naressi BCM, Yang E, Cai JJ, Amaral-Trusty MEJ (2015) A framework radiation hybridmap of buffalo chromosome 1 ordering scaffolds from buffalo genome sequence assembly. Genet Mol Res,14(4):13096-13104

8. Yang E, Chow WN, Wang G, Woo PCY, Lau SKP, Yuen KY, Lin X, Cai JJ∗ (2014) Signaturegene expression reveals novel clues to the molecular mechanisms of dimorphic transition in Penicilliummarneffei. PLoS Genet, 10(10):e1004662.

∗Corresponding author

9. Wang G, Yang E, Brinkmeyer-Langford CL, Cai JJ∗ (2014) Additive, epistatic, and environmentaleffects through the lens of expression variability QTLs in a twin cohort. Genetics, 196(2):413-25. —highlighted article, cover article, featured in Am J Hum Genet & Genetics 2014 Spotlight .

10. Wang G, Yang E, Mandhan I, Brinkmeyer-Langford CL, Cai JJ∗ (2014) Population-level expressionvariability of mitochondrial DNA-encoded genes in humans. Eur J Hum Genet, 22(9):1093-9.

11. Wang G, Yang E, Smith KJ, Zeng Y, Ji G, Connon RE, Fangue NA, Cai JJ∗ (2014) Gene expression re-sponses of threespine stickleback to salinity: implications for salt-sensitive hypertension. Front Genet,5:312.

12. Wang L, Tian X, Gyawali R, Upadhyay S, Foyle D, Wang G, Cai JJ, Lin X (2014) Morphotype tran-sition and sexual reproduction are genetically associated via an RNA-binding protein in a ubiquitousenvironmental pathogen. PLoS Pathog, 10(6):e1004185.

13. Chang CL, Cai JJ, Huang SY, Cheng PJ, Chueh HY, Hsu SY (2014) Adaptive human CDKAL1variants underlie hormonal response variations at the enteroinsular axis. PLoS One, 9(9):e105410.

14. Yang E, Wang G, Woo PC, Lau SK, Chow F, Chong KT, Tse H, Kao RY, Chan CM, Chow WN,Che X, Yuen KY, Cai JJ∗ (2013) Unraveling the molecular basis of temperature-dependent geneticregulation in Penicillium marneffei. Eukaryot Cell, 12(9):1214-24. —highlighted article.

15. Konganti K, Wang G, Yang E, Cai JJ∗ (2013) SBEToolbox: a Matlab toolbox for biological networkanalysis, Evol Bioinform, 9:355-62.

16. Chang CL, Semyonov J, Cheng PJ, Huang SY, Park JI, Tsai HJ, Lin CY, Grutzner F, Soong YK, CaiJJ, Hsu SY (2013) Widespread Divergence of the CEACAM/PSG Genes in Vertebrates and HumansSuggests Sensitivity to Selection. PLoS One, 8(4):e61701.

17. Hulse AM, Cai JJ∗ (2013) Genetic variants contribute to gene expression variability in humans.Genetics, 193(1):95-108. —highlighted article, cover article, featured in Genetics 2013 Spot-light .

18. Brinkmeyer-Langford CL, Cai JJ, Gill CA, Skow LC (2013) Microsatellite variation in the equineMHC. Anim Genet,44(3):267-75.

19. Yang E, Hulse AM, Cai JJ∗ (2012) Evolutionary analysis of sequence divergence and diversity ofduplicate genes in Aspergillus fumigatus. Evol Bioinform, 8:623-44.

20. Woo PC, Lau SK, Liu B, Cai JJ, Chong KT, Tse H, Kao RY, Chan CM, Chow WN, Yuen KY (2011)Draft Genome Sequence of Penicillium marneffei Strain PM1. Eukaryot Cell, 10(12):1740-1.

21. Chang CL, Cai JJ, Park JI, Lo C, Amigo J, Cheng PJ, Chueh HY, Hsu SYT (2011) Identificationof metabolic modifiers that underlie phenotypic variations in energy-balance regulation. Diabetes,60(3):726-34.

22. Shen S, Lin L, Cai JJ, Jiang P, Kenkel EJ, Stroik MR, Sato S, Davidson BL, Xing Y (2011) Widespreadestablishment and regulatory impact of Alu exons in human genes. Proc Natl Acad Sci U S A, 108(7):2837-42.

23. Lu Z, Jiang P, Cai JJ, Xing Y (2011) Context-dependent robustness to 5’ splice site polymorphismsin human populations. Hum Mol Genet, 20(6):1084-96.

24. Chang CL, Cai JJ, Park JI, Lo C, Amigo J, Cheng PJ, Chueh HY, and Hsu SYT (2010) Adaptiveselection of an incretin gene in Eurasian populations. Genome Res, 21(1):21-32 —cover article.

25. Cai JJ∗, Borenstein E, and Petrov DA (2010) Broker genes in human disease. Genome Biol Evol,2:815-25.

26. Tse H, Cai JJ, Tsoi HW, Lam EP, Yuen KY (2010) Natural selection retains overrepresented out-of-frame stop codons against frameshift peptides in prokaryotes. BMC Genomics, 11:491.

27. Woo PCY, Tam EWT, Chong KTK, Cai JJ, Tung ETK, Lau SKP, Yuen KY (2010) High diversity ofpolyketide synthase genes and the melanin biosynthesis gene cluster in Penicillium marneffei. FEBS J,277(18):3750-8.

28. Woo PCY, Lau SKP, (9 co-authors), Cai JJ, Huang JD, Mak W, Pallen MJ, Lok S, Yuen KY (2009)The complete genome and proteome of Laribacter hongkongensis reveal adaptations for survival atdifferent temperatures and habitats. PLoS Genet, 5(3):e1000416.

29. Cai JJ, Macpherson M, Sella G, Petrov DA (2009) Pervasive hitchhiking at coding and regulatorysites in humans. PLoS Genet, 5(1):e1000336 —featured in Stanford Report, January 16, 2009.

30. Cai JJ∗, Petrov DA (2009) Relaxed purifying selection and possibly higher rates of adaptation inlineage-specific genes in humans. Genome Biol Evol, 2:393-409.

31. Cai JJ, Borenstein E, Rong C, Petrov DA (2009) Similarly strong purifying selection acts on humandisease genes of all evolutionary ages. Genome Biol Evol, 1:131-144.

32. Lin L, Shen S, Tye A, Cai JJ, Jiang P, Davidson BL, Xing Y (2008) Diverse splicing patterns ofexonized Alu elements in human tissues. PLoS Genet, 4(10):e1000225.

33. Cai JJ∗ (2008) PGEToolbox: a Matlab toolbox for population genetics and evolution. J Hered,99(4):438-40.

34. Cai JJ∗, Smith DK, Xia X, Yuen KY (2006) MBEToolbox 2: an enhanced Matlab toolbox formolecular biology and evolution. Evol Bioinform, 2:189-192.

35. Cai JJ∗, Woo PCY, Lau SKP, Yuen KY (2006) Accelerated evolutionary rate may be responsible forthe emergence of lineage-specific genes in Ascomycota. J Mol Evol, 63(1):1-11.

36. Woo PC, Chong KT, Cai JJ, Tse H, Lau CC, Zhou AC, Lau SK, Yuen KY (2006) Genomic and exper-imental evidence for a potential sexual cycle in the pathogenic thermal dimorphic fungus Penicilliummarneffei. FEBS Lett, 580(14):3409-3416.

37. Cai JJ∗, Smith DK, Xia X, Yuen KY (2005) MBEToolbox: a Matlab toolbox for sequence data anal-ysis in molecular biology and evolution. BMC Bioinformatics, 6:64. [highly accessed] —featuredin The Scientist, June 20, 2005 v19 i12 p32(2).

38. Woo PCY, Lau SKP, Chan KH, Tsoi HW, Huang Y, Wong BHL, Cai JJ, Wong SSY, Peiris JSM,Chu C, Yuen KY (2005) Characterization and complete genome sequence of a novel coronavirus froma patient with pneumonia. J Virol, 79(2):884-95.

39. Woo PCY, Zhen H, Cai JJ, Yu J, Lau SKP, Wang J, Teng JLL, Wong SS, Tse RH, Chen R, YangH, Liu B, Yuen KY (2003) The mitochondrial genome of the thermal dimorphic fungus Penicilliummarneffei is more closely related to those of molds than yeasts. FEBS Lett, 555(3):469-77.

40. Yuen KY, Pascal G, Wong SS, Glaser P, Woo PCY, Kunst F, Cai JJ, Cheung EY, Medigue C, DanchinA (2003) Exploring the Penicillium marneffei genome. Arch Microbiol, 179(5):339-53.

BOOK CHAPTER

1. Cai JJ∗ (2011) Evolutionary bioinformatics with a scientific computing environment. Systems andComputational Biology—Bioinformatics and Computational Modeling, Ning-Sun Yang (Ed.), ISBN978-953-307-875-5, InTech.

SOFTWARE

1. MBEToolbox, Matlab toolbox for molecular biology and evolution– www.bioinformatics.org/mbetoolbox —over 4,500 downloads since May 2006

2. PGEToolbox, Matlab toolbox for population genetics and evolution– www.bioinformatics.org/pgetoolbox —over 2,200 downloads since March 2007

3. SBEToolbox, Matlab toolbox for systems biology and evolution– www.bioinformatics.org/sbetoolbox

4. Stickleback transcriptome database– stickleback.genomezoo.net

Program Director/Principal Investigator: CHAPKIN, Robert S.

BIOGRAPHICAL SKETCH

NAME Chapkin, Robert S

POSITION TITLE Distinguished Professor, Regents Professor and University Faculty Fellow eRA COMMONS USER NAME

Robert_S_Chapkin EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)


University of Guelph, Ontario, Canada B.Sc. 1981 Nutrition & Biochemistry University of Guelph, Ontario, Canada M.Sc. 1983 Nutrition University of California - Davis Ph.D. 1986 Nutr. & Physiol. Chemistry University of California - Davis Post-doc 1986-88 Cell Biology

A. Personal Statement: Dr. Chapkin is an expert in environmental modulators related to chemoprevention of colon cancer and chronic inflammatory diseases, e.g., inflammatory bowel disease. He has been continuously funded by NIH for the past 25 years and has made highly significant contributions in cancer chemoprevention and T cell/inflammation biology with specific emphasis in: (i) elucidation of signal transduction processes in intestinal stem cells, (ii) membrane biology and nutritional modulation of epithelia/immune cell membrane structure and function, (iii) investigation of the role of inflammation as a critical factor in cancer development, and its modulation by environmental agents, (iv) establishment of models for chronic inflammation and cancer prevention studies, and (v) development of novel noninvasive Systems Biology-based methodologies to assess crosstalk between the gut microbiome and the host transcriptome and its application to translational research. These activities, together with a history of basic and translational (biomarkers) research using cutting-edge genomics and computational biology methodologies, demonstrate that Dr. Chapkin has the scientific credentials necessary to contribute to this proposal. Dr. Chapkin serves as the Deputy Director of the – the P30 NIEHS sponsored Texas A&M Center for Translational Environmental Health Research (CTEHR). B. Positions and Honors: 1986-1988: Postdoctoral Fellow, Immunology-Tumor Biology Laboratory, Department of Cell Biology and

Human Anatomy, School of Medicine, University of California-Davis. 1988-1993: Assistant Professor, Human Nutrition, Center for Environmental and Rural Health, Texas A&M

University. 1991-1992: Pew National Nutrition Program Faculty Scholar. 1996: American Society for Nutrition (ASN) Bio Serv Award in Experimental Animal Nutrition. 1994-1999: Associate Professor, Department of Veterinary Integrated Biosciences and Faculty of Nutrition. 1999-Present: American Institute for Cancer Research Grant Review Panel 1999-Present: Professor, Nutrition, Center for Environmental and Rural Health (CERH), Texas A&M University. 2000: Texas A&M Faculty Fellow Award 2001-2006: Texas A&M University Faculty Fellow Scholar 2002-2005: Chair, Intercollegiate Faculty of Nutrition, Texas A&M University 2002-2004: Editorial Board, Journal of Nutrition 2002-2005: NIH Charter Member: Metabolic Pathology/Chemo-Dietary prevention (CDP) Study Sections 2004-2010: Member, Division Hematol./Oncology, Scott & White Hospital, Texas A&M Health Sci. Center. Co-Director, Genomics and Systems Biology Facility Core, Texas A&M University. 2005-Present: Editorial Board, Chemistry & Physics of Lipids 2005-2010: Director of the P30 NIEHS CERH Genomics & Bioinformatics Core, Texas A&M University 2006: Sigma Xi Distinguished Scientist Award, Texas A&M University Chapter 2007: Texas A&M Senior Faculty Fellow Award 2010-Present: Regents Professor, Texas A&M University System 2010-Present: Editorial Board, British Journal of Nutrition 2011: Distinguished Achievement Award – Association of Former Students, Texas A&M University 2011-2013: Review Editor – Frontiers in Nutrigenomics

2012-Present: Deputy Director – Center for Translational Environmental Health Research, Texas A&M University and Baylor College of Medicine

2012-Present: co-Director – Quantitative Biology Core - Center for Translational Environmental Health Research, Texas A&M University and Baylor College of Medicine

2013: American Society for Nutrition (ASN) Osborne and Mendel Award 2014-Present: Distinguished Professor, Texas A&M University System C. SELECTED (15) PEER REVIEWED PUBLICATIONS FROM A TOTAL OF 229: Most relevant to the current application: C. Zhao, I. Ivanov, E.R. Dougherty, T.J. Hartman, E. Lanza, N.H. Colburn, J.R. Lupton, L.A. Davidson, R.S. Chapkin.

Non-invasive detection of candidate molecular biomarkers in subjects with a history of insulin resistance and colorectal adenomas. Cancer Prevent Res 2:590-597, 2009. PMCID: PMC2745241

L.A. Davidson, N. Wang, I. Ivanov, J. Goldsby, J.R. Lupton, R.S. Chapkin. Identification of actively translated mRNA transcripts in a rat model of early stage colon carcinogenesis. Cancer Prevent Res 2:984-994, 2009. PMCID: PMC2783859

L.A. Davidson, N. Wang, M.S. Shah, I. Ivanov, J.R. Lupton, R.S. Chapkin. n-3 polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colon. Carcinogenesis 30:2077-2084, 2009. PMCID: PMC2792315

R.S. Chapkin, C. Zhao, I. Ivanov, L.A. Davidson, J.S. Goldsby, J.R. Lupton, R.A. Mathai, M.H Monaco, D. Rai, M. Russell, S.M. Donovan, E.R. Dougherty. Non-invasive stool-based detection of infant gastrointestinal development using gene expression profiles from exfoliated epithelial cells. Am J Physiol 298:G582-G589, 2010. PMCID: PMC2867429

M. Shah, S.L. Schwartz, C. Zhao, L.A. Davidson, B. Zhou, J.R. Lupton, I. Ivanov, R.S. Chapkin. Integrated microRNA and mRNA expression profiling in a rat colon carcinogenesis model: Effect of a chemoprotective diet. Physiol Genomics 43:640-654, 2011. PMID:21406606

J.M. Monk, W. Kim, E. Callaway, W. He, B. Weeks, R.C. Alaniz, D.N. McMurray, R.S. Chapkin. Immunomodulatory action of dietary fish oil and targeted deletion of intestinal epithelial cell PPARδ in inflammation-induced colon carcinogenesis. Am J Physiol 302:G153-G167, 2012. PMID:21940900

L.A. Davidson, J.S. Goldsby, E.S. Callaway, N. Barker, R.S. Chapkin. Alteration of colonic stem cell signatures during the regenerative response to injury. Biochmicia et Biophysica Acta-Molec Basis Dis 1822:1600-1607, 2012. PMID: 22750333

H.F. Turk, R. Barhoumi, R.S. Chapkin. Alteration of EGFR spatiotemporal dynamics suppresses signal transduction. PLoS One 7(6):e39682 PMCID: PMC3384615

J.M. Monk, T.Y. Hou, H.F. Turk, B. Weeks, C. Wu, D.N. McMurray, R.S. Chapkin.. Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis. PLoS One 7(11)e49739, PMCID:PMC3500317

S. Schwartz, I. Friedberg, I.V. Ivanov, L.A. Davidson, J.S. Goldsby, D.B. Dahl, D. Herman, M. Wang, S.M. Donovan, R.S. Chapkin. A Metagenomic study of diet-dependent interaction between gut microflora and host in infants reveals differences in developmental and immune responses. Genome Biology 13:R32 doi:10.1186/gb-2012-13-4-r32. PMID: 22546241

K. Triff, K. Konganti, S. Gaddis, B. Zhou, I. Ivanov and R.S. Chapkin. Genome wide analysis of the rat colon reveals site-specific differences in histone modifications and proto-oncogene expression. Physiological Genomics 45:1229-1243, 2013. PMID:24151245

Y.Y. Fan, L.A. Davidson, E.S. Callaway, J.S. Goldsby and R.S. Chapkin. Differential effects of 2 and 3-series prostaglandins on in vitro expansion of Lgr5+ intestinal stem cells. Carcinogenesis 35:606-612, 2014. PMID:24336194

U.H. Jin, S.O. Lee, G. Sridharan, K. Lee, L.A. Davidson, A. Jayaraman, R.S. Chapkin, R. Alaniz and S. Safe. Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities. Molecular Pharmacology 85:777-788, 2014. PMID:24563545.

J.M. Knight, L.A. Davidson, D. Herman, C.R. Martin, J.S. Goldsby, I.V. Ivanov, S.M. Donovan and R.S. Chapkin. Non-invasive analysis of intestinal development in premature and full term infants using RNA-Sequencing. Scientific Reports Nature 4:5453; DOI:10.1038/srep05453 (2014). PMID:24965658

S.M. Donovan, M. Wang, M.H. Monaco, C.R. Martin, L.A. Davidson, I. Ivanov and R.S. Chapkin. Noninvasive molecular fingerprinting of host microbiome interaction in neonates. FEBS Letters (In Press). PMID:25042036.

ZhengdongChengName Zhengdong Cheng Education Princeton University, Ph.D., Physics, 1999

Institute of High Energy Physics, M.S., Particle Physics, 1993 University of Science and Technology of China, B.S., Modern Physics, 1990 2002-2004 Harvard University

Postdoctoral Fellow 2000-2001 ExxonMobil Research & Engineering

Postdoctoral Fellow 1999-2000 Princeton Materials Institute

Postdoctoral Fellow Academic Experience

Texas A&M University, Professor, Chemical Engineering, 2004-Present; Asst Prof, 2004-2010; Assoc. Prof, 2010-present.

2004-present The Professional Program in Biotechnology 2005-present Materials Science and Engineering 2008-present Faculty fellow, Mary Kay O’Connor Process Safety Center

Non-academic experience

2001-2002 DiCon Fiberoptics (CA) Engineer

Certifications & prof registration Current Member-ship in prof organizations

AIChE, ACS, American Physics Society, Sigma Xi, ASGSR (American Society for Gravitational and Space Research)

Honors and Awards William Keeler Memorial Award (Contribution), 2015, Look College of Engineering

Principal Publications of Last Five Years

Chen M., H. Li, Y. Chen, A. Mejia, X. Wang and Z. Cheng “Observation of isotropic–isotropic demixing in colloidal platelet–sphere mixtures” Soft Matter, DOI: 10.1039/c5sm00615e (2015)

He L., J. Ye, M. Shuai, Z. Zhu, X. Zhou, Y. Wang, Y. Li, Z. Su, H. Zhang, Y. Chen, Z. Liu, Z. Cheng and J. Bao, “Graphene oxide liquid crystals for reflective displays without polarizing optics” Nanoscale, 7:5, 1616-1622 (2015).

Wang X., D. Zhao, A. Diaz, I. Nava Medina, H. Wang and Z. Cheng “Thermo-sensitive Discotic Colloidal Liquid Crystals” Soft Matter, 10:39, 7692-7695 (2014) .

Li H., X. Wang, Y. Chen and Z. Cheng, “Temperature-dependent I-N Transition of Charged Nanoplates” Phys Rev E 90, 020504(R) (2014).

Mejia A., Ratna Ng (Undergrad), Peter Nguyen (Undergrad),Min Shuai, Hugo Y. Acosta, M. Sam Mannan and Z. Cheng, “Thermo-responsive discotic nematic hydrogels” Soft Matter 9, 10257-10264 (2013).

S. R. Pullela, Q. Wang, Z. Cheng, “Self-oscillating Structural Polymer Gels” Advances in Nanoparticles 2,94-98 (2013)

A. F. Mejia, Ratna Ng (Undergraduate), Peter Nguyen (Undergraduate),Min Shuai, Hugo Y. Acosta, M. Sam Mannan and Z. Cheng, “Thermo-responsive discotic nematic hydrogels” Soft Matter 9, 10257-10264 (2013).

M. Shuai, Andres F. Mejia, Y. Chang and Z. Cheng,“Hydrothermal synthesis oflayered a-zirconium phosphate disks: control of aspect ratio andpolydispersity for nano-architecture” Cryst. Eng. Comm. 15, 1970-1977(2013).

J. S. Guevara (undergraduate), A.F. Mejia, Y. Chang, M. Shuai, M.S. Sam

Mannan, Z. Cheng, “Stabilization of Pickering Foams by High-aspect-ratio Nano-sheets” Soft Matter 9, 1327-1336 (2013).

A.F. Mejia, A. Diaz, S. Pullela, Y. Chang, M.S. Mannan, A. Clearfield, and Z. Cheng, “Pickering Emulsions Stabilized by Amphiphilic Nano-sheets” Soft Matter 8, 10245-10253 (2012) (Journal cover).

A.F. Mejia, Y. Chang, R. Ng(undergraduate), M. Shuai, M.S. Mannan, and Z. Cheng, “Aspect Ratio and Polydispersity Dependence of Isotropic-nematic Transition in Discotic Suspensions” Physical Review E 85, 061708 (2012). Figure selected as part of PRE kaleidoscope images, June 2012.

Y. Chang, A.F. Mejia, Z. Cheng, D. Di, and G.B. McKenna, “Gelation via IonExchange in Discotic Suspensions” Phys. Rev. Lett. 108, 247802 (2012).

X. Di, K. Z. Win, G. B. Mc Kenna, T. Narita, F. Lequeux, S. Rao Pullela, and Z.Cheng, “Signature of structure recovery in colloidal glasses” Phys. Rev.Lett. 106, 2011, 095701 (2011)

Service Activities Mentor to undergraduate students in Chemical engineering. Serve on various advisor committees of graduate students. Actively participated in faculty recruiting (went to seminars and meals, giving

feed back to the department) Actively participate in graduate student recruiting (networking with professors in

India and China, help evaluating international students) Serve as advisor to “Afghan Student Association” Mbr. of the MSEN Curriculum Committee (since 2010). Mbr. of the T&P Committee of the Chem. Engr. Department (since 2010). Member of the Awards Committee of the Chemical Engineering Department

(2011-2015). Member of the undergraduate committee (2012-2014) Taught the summer course to facilitate the smooth flow of the students’ study

(CHEN 323, 2012) Taught Freshman Engineer course (Fall 2012) (solving the short hand problem

in the department) Taught MSEN 603 (SP 2014, extra teaching load to solve the shorthand problem

of the newly established MSEN department) Taught CHEN 455 (SUM 14,15, China Study abroad program)

Professional Development Activities in the Last Five Years

NAS”“Liquid Crystals of Nanoplates”, $747,000, Sept.1, 2013-Aug. 31, 2018, PI: Zhengdong Cheng. ITF (the Industry Technology Facilitator, UK. www.oil-itf.com. Chevron, Wintershall of BASF and Dong Energy), “Nanoplate Surfactants for Enhanced Oil Recovery”, $625,082, Nov. 1, 2011-Aug. 31, 2014, PI: Zhengdong Cheng.

NSF, “Phase Transitions in Colloidal Suspensions of Disks”, $294,000, July 1, 2010-June 30, 2014, PI: Zhengdong Cheng.

Principal Investigator/Program Director (Last, First, Middle): COATES, Craig, J.

PHS 398/2590 (Rev. 09/04) Page Biographical Sketch Format Page

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.


NAME Coates, Craig, J.

POSITION TITLE Assistant Professor

eRA COMMONS USER NAME cjcoates EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)


Australian National University, Canberra, Australia B.Sc. (Hons) 1988-1991 Biochemistry and

Molecular Biology Australian National University, Canberra, Australia Ph.D. 1992-1996 Biochemistry and

Molecular Biology

University of California, Irvine, Irvine, California Postdoctoral Training 1996-1998 Insect Molecular Biology

A. Positions and Honors Employment 1996-1998 Postdoctoral Research Associate, UCI, Irvine California 1999 - 2005 Assistant Professor, Texas A&M University 2005 - Associate Professor, Texas A&M University Member, Faculty of Genetics Member, Faculty of Biotechnology Other Experience and Professional Memberships March 2005 Chair, Session VI at the 4th International Workshop on Transgenesis and Genomics of

Invertebrate Organisms June 2005 Study Section Member, NIH - IDM-M July 2005 Study Section Member, NIH – VB Entomological Society of America (ESA) Honors 2002 Texas A&M University Center for Teaching Excellence Montague Scholar B. Selected peer-reviewed publications (Postdocs and Graduate Students as shown)

Jasinskiene, N., C.J. Coates, A. Ashikyan and A.A. James (2003). High efficiency, site-specific excision of a marker gene by the phage P1 cre-loxP system in the yellow fever mosquito, Aedes aegypti. Nucleic Acids Res. 31: e147. O’Brochta, D.A., N. Sethuraman, R. Wilson, R.H. Hice, A.C. Pinkerton, C.S. Levasque, D.K. Bideshi, N. Jaskinskiene, C.J. Coates, A. A. James, M.J. Lehane and P.W. Atkinson (2003). Gene vector and transposable element behavior in mosquitoes. Journal of Experimental Biology, 206: 3823-3834. Tu, Z. & Coates, C.J. (2004) Mosquito Transposable Elements. Insect Biochem. Mol. Biol. 34:631-44.

Principal Investigator/Program Director (Last, First, Middle): COATES, Craig, J.

PHS 398/2590 (Rev. 09/04) Page Continuation Format Page

Cônsoli, F.L., Tian, H., Vinson, S.B. and Coates, C.J.* (2004) Differential gene expression during wing morph differentiation of the ectoparasitoid Melittobia digitata (Hym., Eulophidae). Comp. Biochem. Physiol. A. Mol. Integr. Physiol. 138: 229-39. Tian, H., Vinson, S.B., and Coates, C.J.* (2004) Differential gene expression between alate and dealate queens in the red imported fire ant, Solenopsis invicta Buren (Hymenoptera: Formicidae) Insect Biochemistry and Molecular Biology 34: 937-49. Pledger, D.W., Fu, Y.Q. and Coates, C.J.* (2004) Analyses of cis-acting elements that affect the transposition of MosI mariner transposons in vivo. Molecular Genetics and Genomics 272: 67-75 Gray, C. and Coates, C.J.* (2004) High-level gene expression in Aedes albopictus cells using a baculovirus Hr3 enhancer and IE1 transactivator. BioMed Central 5: 8. Mohammed, A. and Coates, C.J. (2004) Promoter and piggyBac activities within embryos of the potato tuber moth, Phthorimaea operculella, Zeller (Lepidoptera: Gelechiidae). Gene, 342: 293-301. Chowdhury, M.H., Julian, A.M., Coates, C.J. and Cote, G.L. (2004) Detection of differences in oligonucleotide influenced aggregation of colloidal gold nanoparticles using absorption spectroscopy. Journal of Biomedical Optics, 9: 1347-1357. Adelman, Z.N., Jasinskiene, N., Vally, K.J.M., Peek, P., Travanty, E.A., Olson, K.E., Brown, S.E., Stephens, J.L., Knudson, D.L., Coates, C.J. and James, A.A. (2004) Formation and loss of large, unstable tandem arrays of the piggyBac transposable element in the yellow fever mosquito, Aedes aegypti. Transgenic Research 13:411-25. Gray, C.E. & Coates, C.J. (2005) Cloning and characterization of cDNAs encoding putative CTCFs in the mosquitoes, Aedes aegypti and Anopheles gambiae. BMC Molecular Biology 6:16 Pledger, D.W. & Coates, C.J. (2005) Mutant MosI mariner transposons are hyperactive in Aedes aegypti. Insect Biochem. Mol. Biol.,35:1199-207 Li, H., Medina, F., Vinson, S.B. & Coates, C.J. (2005) Isolation, Characterization and Molecular Identification of Bacteria from the Red Imported Fire Ant (Solenopsis invicta) Midgut. Journal of Invertebrate Pathology 89:203-9 Li, H., Medina, F., Vinson, S.B. & Coates, C.J. (in press) Genetic Transformation of Midgut Bacteria from the Red Imported Fire Ant (Solenopsis invicta). Current Microbiology. Kolb, A.F., Coates, C.J., Kaminski, J.M., Summers, J.B., Miller, A.D. & Segal, D.J. (2005) Site-directed genome modification: nucleic acid and protein modules for targeted integration and gene correction. Trends in Biotechnology 23:399-406 Coates, C.J., Kaminski, J.M., Summers, J.B, Segal, D.J., Miller, A.D., & Kolb, A.F. (2005) Site-directed genome modification: derivatives of DNA modifying enzymes as targeting tools. Trends in Biotechnology 23:407-19 Maragathavally, K.J., Kaminski, J.M., Coates, C.J. (2006) Chimeric Mos1 and piggyBac transposases result in site-directed integration. FASEB J. 20:1880-2.

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Brett CornwellExecutive Director

(979) [email protected]

Brett Cornwell is the Executive Director for Texas A&M Technology Commercialization. He leads the Licensing and IP Management and New Ventures division activities. This includes partnering with industry to commercialize the A&M System’s portfolio of technologies to spin out new compa-nies in support of the commercialization of technologies. The services for new spin out companies include screening stage market assessments, business plan development, marketing plan develop-ment, market research studies, strategic business planning, and the development of venture pitches.

He is on the adjunct graduate faculty at Texas A&M University teaching courses in technolo-gy commercialization in the Mays Business School. His courses focus on technology market screening and evaluation, venture planning and evaluation, and business planning and launch. He is also a Faculty member at the IC2 Institute at The University of Texas at Austin and is an Ad-junct Lecturer in the McCombs School at the University of Texas at Austin as an instructor in the Master’s in Science and Technology Commercialization degree program. He has led a number of international technology commercialization benchmarking and training projects including projects with CONACYT in Mexico, Innovisa in Portugal, The University of Otago in New Zea-land, and ProTon in Europe.

Brett Cornwell was a program coordinator for the NASA Mid-Continent Technology Transfer Center (MCTTC) for ten years and served as the deputy director for three. At MCTTC, his experi-ence and knowledge was used to write marketing studies for new technologies, outreach to companies, and define market opportunities and barriers for potential licensees.

He has over twenty years experience in technology transfer and two years experience with small companies as sales and marketing manager. He was recognized as the Outstanding Technology Transfer Intermediary in Arkansas in 1997, received the Distinguished Service Award from the Mid-Continent Federal Laboratory Consortium in 2001, designed major portions of the Federal Laboratory Consortium’s Technology Assessment process for the RIB-IT program and has been published in R&D Enterprise, Asia Pacific. He is a co-author of Marketing Scientific Results pub-lished in October 2004.

Cornwell holds an MBA from Texas A&M University and a BBA in marketing from Baylor Univer-sity.

CURRICULUM VITAE

ERNEST GUS COTHRAN, JR.

EDUCATION B.S. Biology, North Texas State University, Denton, Texas - 1973 M.S. Zoology, North Texas State University, Denton, Texas - 1975 Ph.D. University of Oklahoma, Norman, Oklahoma - 1982 Positions and Employment 1981-1982 Research Analyst, Population Genetics Laboratory, Savannah River Ecology Laboratory, Aiken, SC 1982-1985 Postdoctoral Scientist, Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 1985-1986 Assistant Scientist, Department of Genetics, Southwest Foundation for

Biomedical Research, San Antonio, TX 1986-1992 Assistant Research Professor, Department of Veterinary Science, University of

Kentucky, Lexington, KY 1991-1992 Adjunct Professor, Department of Biological Sciences, University of North

Texas, Denton, TX 1992-2000 Associate Research Professor, Department of Veterinary Science, University of

Kentucky, Lexington, KY 2000-2006 Research Professor, Department of Veterinary Science, University of Kentucky,

Lexington, KY 2006- Clinical Professor, Department of Veterinary Integrative Biosciences, College

of Veterinary Medicine and Biomedical Science, Texas A&M University, College Station, TX

GRANTS AND AWARDS: Principal Investigator- Bureau of Land Management . Genetic variation in feral horse and burro herds. Total cost for 2000-2008. $75,000.00.

Principal Investigator- United States Trotting Association. An analysis of genetic variation in the Standardbred horse. 1yr. Total costs $27,325.00 . 2003.

Principal Investigator- Peruvian Paso Breeders Association. The genetic basis of Degenerative Suspensory Ligament Demitis in the Peruvian Paso horse. 3yr. Total cost $300,000.00. 2003-2006.

Principal Investigator- U.S. Dept. of the Interior, Bureau of Land Management. Genetic analysis of wild horses and burros. 5yrs. Total cost $273,000.00. 2009-2013. PROFESSIONAL AND HONORARY SOCIETIES: American Association for the Advancement of Science Society for the Study of Evolution Sigma Xi American Society of Mammalogists International Society for Animal Genetics - Elected to Standing Committee for Genetics of the Horse,

1988 and 1992. Elected to Standing Committee for Genetics of Deer, 1992 – present. ISAG/FAO Domestic Animal Relationships Programme advisory committee. 1995-present. Elected to Standing Committee of Thoroughbred Horses 1994 and Chairman of Committee 1996-2004. Elected to

Standing Committee for Domestic Animal Genetic Diversity 1996 - present. Elected to Equine Genetic Standing Committee and Chair 2004-2006. American Genetic Association. Society of Conservation Biologists.

PUBLICATIONS: Lindgren, G., N. Backstrom, J. Swineburne, L. Hellborg, A. Einarsson, K. Sandberg, G. Cothran, C. Vila, M. Binns, and H. Ellegren. 2004. Limited number of patrilines in horse domestication. Nature Genetics 36:335-336. Luis, C., E.G. Cothran, M.M. Oom, and E. Bailey. 2005. Major histocompatibility complex locus DRA polymorphism in the endangered Sorraia horse and related breeds. Journal of Animal Breeding and Genetics. 122:69-72. Cothran, E.G. and C. Luis. 2005. Genetic distance as a tool in conservation of rare horse breeds. In: Conservation Genetics of Endangered Horse Breeds. Bodo, I., L. Alderson, and B. Langolis eds. Wageningen Academic Publishers, Wageningen, The Netherlands. Pp 55-71. Luis, C., C. Bastros-Silveira, E.G. Cothran, and M.M. Oom. 2006. Iberian origins of New World horse breeds. Journal of Heredity 97:107-113. Brunberg, E., L. Andersson, G. Cothran, K. Sandberg, S. Mikko, and G. Lindgren. 2006. A missense mutation in PMEL17 is associated with Silver dapple coat color in the horse. BMC Genomics 7:46-55. Luis, C., R. Juras, M.M. Oom, and E.G. Cothran. 2007. Genetic diversity and relationships of Portuguese and other horse breeds based on protein and microsatellite loci variation. Animal Genetics 38:20-27. Luís, C., E.G. Cothran, and M.M. Oom. 2007. Inbreeding and genetic structure in the endangered Sorraia horse breed. Implications for its conservation and management. Journal of Heredity 98:232-237. Andersson, L.S, R. Juras, D.T. Ramsey, J. Eason-Butler, S. Ewart, G. Cothran, and G. Lindgren. 2009. Equine Multiple Congenital Ocular Anomalies maps to a 4.9 megabase interval on horse chromosome 6. BMC Genomics 9:88. R. Juras, DVM, PhD, T. Raudsepp, PhD, P.J. Das, DVM, PhD, E. Conant, PhD, and E. G.Cothran, PhD. 2010. XX/XY Blood Lymphocyte Chimerism in Heterosexual Dizygotic Twinsfrom an American Bashkir Curly Horse. Case Report. J.Equine Vet. Sci. 30:575-580.Warmuth, V., A. Eriksson, M. Bower, J. Canon, G. Cothran, O. Distal, M.-L. Manica. 2011. EuropeanDomestic Horses originated in two Holocene refugia. PLoS ONE 6(3):e 18194.Conant, E.K., R. Juras and E.G. Cothran. 2011. A microsatellite analysis of fiveColonial Spanish horse populations of the south eastern United States. Anim. Genet. 43:53-62.Prystupa, J.M., R. Juras, E.G. Cothran, F.C. Buchanan and Y. Plante. 2012. Genetic diversity andadmixture among Canadian, Mountain and Moorland, and Nordic pony populations. Animal 6:19-30.Prystupa, J.M., P. Hind, E.G. Cothran and Y. Plante. 2012. Maternal lineages in native Canadian equinepopulations and their relationship to the Nordic and Mountain and Moorland pony breeds. Journal ofHeredity doi:10.1093/jhered/ess003.Doan, R., N. Cohen, J. Harrington, K. Veazy, R. Juras, G. Cothran, M. McCue, L. Skow and S.V. Dindot.2012. Identification of copy number variants in horses. Genome Research 22:899-907.Andersson, L.S., L. Larhammar, F. Memic, H. Wootz, D. Schwochow, C-J. Rubin, K. Patra, T. Arnason,L. Wellbring, G. Hjalm, F. Imsland, J.L. Peterson, M.E. McCue, J.R. Mickelson, G. Cothran, N. Ahituv,L. Roepstorff, S. Mikko, A, Vallstedt, G. Lindgren, L. Andersson and K. Kullander. 2012. Mutations inDMRT3 affect locomotion in horses and spinal circuit function in mice. Nature 488:642-646.Petersen, Jessica L., James R. Mickelson, E. Gus Cothran, et al. 2013. Genetic diversity in the modern

horse illustrated from whole-genome SNP data. PLoS One 8(1):e54997.Khanshour, A., E. Conant, R. Juras, and E.G. Cothran. 2013. Microsatellite analysis of genetic diversityand population structure of Arabian horse populations. Journal of Heredity doi:10.1093.

BIOGRAPHICAL SKETCH

NAME Criscitiello, Michael Frederick POSITION TITLE Associate Professor of Veterinary Pathobiology Email Address:

[email protected]

Phone Number: 1 979 845 4207



YEAR(S) FIELD OF STUDY

University of North Carolina, Chapel Hill, NC B.S. 1989-1993 Biology East Carolina University, Greenville, NC M.S. 1995-1997 Molecular Biology

University of Miami, Miami, FL Ph.D. 1997-2003 Microbiology and Immunology

University of Maryland, Baltimore, MD Postdoctoral 2003-2008 Immunology

The Comparative Immunogenetics Laboratory studies immunology, molecular genetics and evolution. Most of my group’s research focuses on the natural history of the vertebrate adaptive immune system, with particular attention given to the genetics of lymphocyte antigen receptors, mucosal immune mechanisms in the gut and antigen presentation, as well as applied shrimp immunogenomics in mariculture. A focus of my lab has been antigen receptor immunogenetics in aquatic vertebrates, and we are well-poised to investigate the adaptive immune loci of these two manatee species.

2008-present; Assistant Professor in Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University (TAMU)

2008-present; Ecology and Evolutionary Biology Interdisciplinary Research Program (TAMU)

2008-present; Interdisciplinary Faculty of Genetics (TAMU)

2009-present; Whole Systems Genomics Initiative (TAMU)

2010-present; Interdisciplinary Faculty of Toxicology (TAMU)

2010-present; Professional Program in Biotechnology (TAMU)

2014-present; joint appointment in Microbial Pathogenesis and Immunology, School of Medicine (TAMU)

2014-present; Associate Professor with tenure (TAMU)

Peer Reviewed Publications from last three years (total n=28, h index=12) Criscitiello M.F., Y. Ohta, M.D. Graham, J.O. Eubanks, P.L. Chen, and M.F. Flajnik. “Shark class II invariant chain reveals

ancient conserved relationships with cathepsins and MHC class II.” Developmental and Comparative Immunology 36:521-533, 2012. PMID: 21996610

Du, C.C., S.M. Mashoof, and M.F. Criscitiello. “Oral immunization of the African clawed frog (Xenopus laevis) upregulates the mucosal immunoglobulin IgX.” Veterinary Immunology and Immunopathology 145:493-498, 2012. PMID: 22100190

Romoser A.A., D.E. Figueroa, A. Sooresh, K. Scribner, P.L. Chen, W. Porter, M.F. Criscitiello, and C.M. Sayes. “Distinct immunomodulatory effects of a panel of nanoparticles in human dermal fibroblasts.” Toxicological Letters 210:293-301, 2012. PMID: 22342292

Flajnik, M.F., T. Tlapakova, M.F. Criscitiello, V. Krylov, and Y. Ohta. “Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member, B7H7, and of B7’s historical relationship with the MHC.” Immunogenetics 64:571-590, 2012. PMID: 22488247

Pohlenz, C., A. Buentello, M.F. Criscitiello, W. Mwangi, R. Smith, and D. Gatlin. “Synergies between vaccination and dietary arginine and glutamine supplementation improve the immune response of channel catfish against Edwardsiella ictaluri.” Fish and Shellfish Immunology 33:543-551, 2012. PMID: 22728565

Criscitiello, M.F. and P. de Figueiredo. “Fifty shades of immune defense.” PLoS Pathogens 9(2): e1003110, 2013. PMID 2340888

Zimmer, D.B., J.O. Eubanks, D. Ramakrishnan, and M.F. Criscitiello. “Evolution of the S100 family of calcium sensor proteins.” Cell Calcium 53(3):170-9, 2013. PMID: 23246155

Mashoof, S., A. Goodroe, C.C. Du, J.O. Eubanks, N. Jacobs, J.M. Steiner, I. Tizard, J.S. Suchodolski, and M.F. Criscitiello. “Ancient T-independence of mucosal IgX/A: gut microbiota unaffected by larval thymectomy in Xenopus laevis.” Mucosal Immunology 6(2):358-68, 2013. PMID: 22929561

Wang F., D.C. Ekiert, I. Ahmad, W. Yu, Y. Zhang, O. Bazirgan, A. Torkamani, T. Raudsepp, W. Mwangi, M.F. Criscitiello, I.A. Wilson, P.G. Schultz, V.V. Smider. “Reshaping antibody diversity.” Cell (153)6:511-8, 2013. PMID: 23746848

Criscitiello, M.F., M.B. Dickman J.E. Samuel and P. de Figueiredo. “Tripping on acid: trans-kingdom perspectives on biological acids in immunity and pathogenesis.” PLoS Pathogens 9(7):e1003402, 2013. PMID: 23874196

López-Zavala, A.A., J.S. Carrasco-Miranda, K.D. Garcia-Orozco, R. Sugich-Miranda, J.M. Hernandez-Flores, M.F. Criscitiello, Luis G. Brieba, Rogerio R. Sotelo-Mundo and Enrique Rudiño-Piñera. “Crystal structure of shrimp arginine kinase in binary complex with arginine - a molecular view of the phosphagen precursor binding to the enzyme.” Journal of Bioenergetics and Biomembranes 45(6):511-8, 2013. PMID: 23746848

Mashoof, S.M., C. Pohlenz, P.C. Chen, D. Gatlin, A. Buentello and M.F. Criscitiello. “Expressed IgH μ and τ transcripts share diversity segment in ranched Thunnus orientalis.” Developmental and Comparative Immunology 43(1):76-86, 2014. PMID: 24231183

Romoser, A.A., D.E. Figueroa, M.F. Criscitiello, and C.S. Sayes. “Engineered nanoparticles induce DNA damage in primary human skin cells, even at low doses.” Nano LIFE 4(1):1440001-13, 2014.

Criscitiello, M.F. “What the shark immune system can and cannot provide for the expanding landscape of immunotherapy.” Expert Opinion in Drug Discovery 9(7):725-739, 2014. PMID: 24836096.

Federal Research Support as PI Ongoing Research Support NSF Criscitiello (PI) 2013-2016 Evolution of loci critical in antigen recognition Role: PI $655,000 (to Criscitiello) INAPESCA Criscitiello (PI) 2011-2015 RNA Sequencing for Annotation of a Reference Genome for Augmentation of Shrimp Disease Resistance (renewal) Role: Co-PI $96,420 (to Criscitiello) Recently Completed Research Support National Institutes of Health (AI73888) Criscitiello (PI) 2008-2011 Origins of Specialized Mucosal Lymphocyte Subsets and Immunoglobulin Isotypes Role: PI $270,000 (to Criscitiello)


BIOGRAPHICAL SKETCH

NAME Paul de Figueiredo


eRA COMMONS USER NAME (credential, e.g., agency login) PDEFIGUEIREDO EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)


Rice University, Houston TX B.A. 1986 Mathematics & Political Science Stanford, Palo Alto CA M.A. 1989 Religious Studies Cornell, Ithaca NY Ph.D. 1997 Biochemistry, Molecular & Cell Biology MIT, Cambridge MA Postdoc 1998-1999 Vertebrate genetics U. Washington, Seattle WA Postdoc 2000-2005 Microbiology

A. PERSONAL STATEMENT N/A

B. POSITIONS AND HONORS SELECTED RECENT PROFESSIONAL EXPERIENCE 2006 Member, Faculty of Genetics, Texas A&M University 2010 Investigator, Norman Borlaug Center, Texas A&M University 2013 Assoc. Professor, Dept. of Microbial Pathogenesis and Immunology, Texas A&M Health

Science Center

SELECTED OTHER EXPERIENCE AND PROFESSIONAL ACTIVITIES 2008, 2010 Panel Member, NSF Integrated and Organismal systems (IOS) 2008-2012 Panel Member, NIH Special Emphasis Panel/Scientific Review Group ZRG1 IDM-A,

Intracellular bacterial pathogenesis 2009-2012 Panel Member, NSF Chemical, Bioengineering, Environmental, and Transport Systems

(CBET) 2011 Panel Member, CDC-NIH Family History and Diamond Blackfan Anemia 2005-present Member, American Association for the Advancement of Science 2010-present Associate Editor, Frontiers in Cellular and Infection Microbiology 2013-present Associate Editor, Frontiers in Cell and Developmental Biology

C. SELECTED SERVICE TEXAS A&M UNIVERSITY 2006-2013 Co-Director, Research Experience for Undergraduates, Texas A&M Agrilife Research 2008-present Faculty mentor, University Scholars Program 2009-present Faculty Mentor, “Invisible Jungle”, a weekly National Public Radio broadcast 2009-2012 Member, Graduate Student Recruiting Committee, Faculty of Genetics 2009-2012 Member, Curriculum Committee, Biotechnology Program 2012-present Member, Institutional Biosafety Committee 2013-present Member, Faculty of Genetics Graduate Mentoring Committee D. PUBLICATIONS (30 total, 1 in press, 1 in review) SELECTED RECENT PUBLICATIONS 1. Qin QM, Pei J, Ancona V, Shaw BD, Ficht TA, de Figueiredo P. RNAi screen of endoplasmic reticulum-

associated host factors reveals a role for IRE1a in supporting Brucella replication. PLOS PATHOG. 2008 Jul 25;4(7):e1000110 PMID: 18654626

2. Qin, Q, Luo J, Lin X, Pei J, Ficht TA, de Figueiredo P. Functional analysis of host factors that mediate Cryptococcus neoformans intracellular trafficking. PLOS PATHOG. 2011. Jun;7(6):e1002078. Epub 2011 Jun 16. PMID: 21698225

3. Bechler M., de Figueiredo P, Brown WJ. A PLA1-2 punch regulates the Golgi complex.


TRENDS CELL BIOL. 2011 Nov 28, PMID: 22130221 4. Criscitiello M, de Figueiredo P. Fifty shades of immune defense.

PLOS PATHOG. 2013 9(2): e1003110. doi:10.1371/journal.ppat.1003110 PMID: 23408882 5. Han A, Hou H, Li L, Kim HS, de Figueiredo P. Microfabricated devices in microbial bioenergy sciences.

TRENDS IN BIOTECHNOL. 2013. pii: S0167-7799(12)00221-1. PMID: 23453527 6. Criscitiello M, Dickman MB, Samuel JE and de Figueiredo P. Tripping on acid: trans-Kingdom perspectives on biological acids in immunity and pathogenesis

PLOS PATHOG. 2013. 9(7): e1003402. doi:10.1371/journal.ppat.1003402. PMID: 23874196 7. Dickman and de Figueiredo. Death be not proud––cell death control in host fungal interactions PLOS PATHOG. 2013. 9(9): e1003542. doi:10.1371/journal.ppat.100354 D. RESEARCH SUPPORT Current support 1. Texas A&M––CAPES Program (PI: de Figueiredo; co-PIs: de Lima Santos, Ficht, Rice-Ficht), Brucella

spp. neuropathogenesis and vaccine development, 5/2014-5/2015 2. The Bill & Melinda Gates Foundation (PI: de Figueiredo; co-PIs: McMurray, Ficht), Defeating antibiotic

resistance before it emerges, 5/2012-11/2014 3. Qatar National Research Fund (QNRF) (PI: Sadr; co-PI: Han; co-PI: de Figueiredo), Microfluidic Platforms

for High-Throughput Screening of Microbes Utilizing Wastewater, 9/11/2012-9/10/2015 4. Texas A&M-–Weizmann Research Program (PI: Ficht, co-PIs: de Figueiredo, Elazar), Mechanisms

mediating intracellular parasitism by Cryptococcus neoformans, 7/2012-7/2014 5. Texas A&M AgriLife Research (PI: de Figueiredo, co-PI: Dickman), A Universal Small Molecule System for

the Non-lytic Secretion of Oils from Living Cells. 9/13-9/15 Prior support (last 4 years) 6. Shwachman Diamond Research Foundation (PI: de Figueiredo), Development of small molecule

therapeutics for Shwachman Diamond Syndrome, 11/2011-4/2013 7. NSF DBI (PI: Gonzalez; co-PI: de Figueiredo), REU: The Plant-Microbe Interface, 4/2011-4/2014 8. The Bill & Melinda Gates Foundation (PI: Han; co-PI: de Figueiredo), Hybrid Microbial-Electrochemical

System for Waste Utilization, 11/2011-11/2013 9. Defense Threat Reduction Agency (PI: Han; co-PI: de Figueiredo), Microfuidics Based High Throughput

Analysis of Polymicrobial Interactions, 6/2011-6/2013 10. Leaf Energy, Inc. (PI: Dickman; co-PI: de Figueiredo), Microdiesel–– a next generation biofuel platform,

6/2012-6/2013 11. Texas A&M Genomics and Bioinformatics Seed Grant Program (PI: Ficht; co-PI: de Figueiredo),

Subcellular pathogenomics, 7/2012-7/2013 12. Congressionally Directed Medical Research Program (PI: de Figueiredo), Shwachman Diamond

Syndrome: Linking Bone Marrow Failure to Global Acetylome Dysregulation, 11/2011-11/2012 13. NSF/CBET (PI: Paul de Figueiredo; co-PI: Han), Microbe-mediated electricity generation, 8/2009-8/2012 14. Shwachman Diamond Syndrome Foundation (SDSF) (PI: de Figueiredo), Development of small molecule

therapeutics for Shwachman Diamond syndrome, 11/2010-11/2011 15. Diamond Blackfan Anemia Foundation (DBAF) (PI: de Figueiredo), Discovery of therapeutics for treating

Diamond Blackfan Anemia. 5/2010-5/2011 16. Department of Defense Army Research Office (PI: de Figueiredo; co-PIs–– Samuel, Ficht, Rice-Ficht,

Adams), Confocal microscopy instrumentation for biodefense research 17. USDA APHIS (PI: de Figueiredo; Appel, co-PI), Cyclic di-GMP regulation Xylella fastidiosa virulence,

3/2007-3/2010 18. NIH NIAID (PI: de Figueiredo), Microscopy for infectious disease research, 1/2010 19. NIH NIDDK (PI: de Figueiredo), Supplement for undergraduate research, 6/2009-8/2010 20. NIH MLPCN (PI: de Figueiredo), Drug discovery for bone marrow failure diseases, 6/2009-6/2011, No

monies, resources only 21. NIH NIAID, (PI: de Figueiredo; co-PI: Ficht), Identification and analysis of host factors that support

Brucella infection, 2/08-1/2010 22. NSF IOS (PI: de Figueiredo; co-PI: Ficht), Molecular analysis of Brucella host factors, 8/2008-8/2011

Principal Investigator/Program Director: DERR, JAMES N. BIOGRAPHICAL SKETCH

NAME DERR, James N. POSITION TITLE Professor

EDUCATION/TRAINING INSTITUTION AND LOCATION DEGREE YEAR

CONFERRED FIELD OF STUDY

Cameron University B.S. 1980 Biology Sul Ross State University M.S. 1982 Zoology Texas A&M University Ph.D. 1990 Genetics Professional Experience 1985-1987 Graduate Teaching Assistant, WFSC, TAMU 1987-1989 Tom Slick Research Fellow, WFSC, TAMU 1989-1990 Staff Research Assistant, WFSC, TAMU 1990-1993 Post-Doc Research Associate, ANSC, TAMU 1993-1999 Assistant Professor, VTPB, TAMU 1995- Director, DNA Technologies Laboratory, VTPB, TAMU 1999- 2006 Associate Professor, VTPB, TAMU 2000-2002 Chair, Graduate Faculty of Genetics, TAMU 2001-2003 President-Elect and President, Texas Genetics Society 2006 - Professor, VTPB. TAMU Honors and Awards Phi Kappa Phi Distinguished Alumnus Award, Cameron University, 2000. Outstanding Doctoral Student, Department of Wildlife and Fisheries Sciences, TAMU, 1987-1988. Outstanding Student in Training, The Texas Genetics Society. April, 1987, College Station, Texas. Recipient of the Tom Slick Research Fellowship, by the College of Agriculture, TAMU 1987-1988. President, Association of Graduate Wildlife and Fisheries Scientists, TAMU, 1985-1986. Peer-reviewed publications (last 10 years).

Seabury, C.M., and J.N. Derr. 2004. Identification of a novel ovine PrP polymorphism and scrapie resistance genotypes for St. Croix White and a related composite breed. Cytogenetic and Genome Research. 102: 85-88. Schnabel, R.D., J.F. Taylor and J.N. Derr. 2004. Development of a linkage map and QTL scan for growth traits in North American bison. Cytogenetic and Genome Research. 102:59-64. Seabury, C.M., J.E. Womack, J. Piedrahita, and J.N. Derr. 2004. Comparative PRNP genotyping of U.S cattle sires for potential association with BSE. Mammalian Genome.15:828-833.Seabury, C.M., R.L. Honeycutt, A.P. Rooney, N.D. Halbert and J.N. Derr. 2004. Novel prion protein gene (PRNP) variants and evidence for strong purifying selection in functionally important regions of bovine exon 3. Proceedings of the National Academy of Sciences. 101(42):15142-15147. Halbert, N., Raudsepp, T., Chowdhary, B., and J.N. Derr. 2004. The legacy of Charles Goodnight: Conservation genetic analysis of the Texas State Bison Herd. Journal of Mammalogy. 85(5):925-931. Halbert, N.R., W.E. Grant, and J.N. Derr. 2005. Genetic and demographic consequences of importing animals into a small population: A simulation model of the Texas State Bison Herd (U.S.A.). Ecological Modeling. 181:263-276. Seabury, C. M., N. D. Halbert, P. J. P. Gogan, J. W. Templeton, and J. N. Derr. 2004. An evaluation of PRNP exon 3 variation and association with seroprevalence of Brucella spp. antibodies in Yellowstone bison. Animal Genetics 36:104-110. Halbert, N., T. Ward, R. Schnabel, J. Taylor, and J. Derr. 2005. Conservation genomics:

Principal Investigator/Program Director: DERR, JAMES N.

disequilibrium mapping of domestic cattle chromosomal segments in North American bison populations. Molecular Ecology 14:2343-2362. White, S.N., N.D. Halbert, K.H. Taylor, J.N. Derr, and J.E. Womack. 2005. Comparison of segregating TLR4 variation in American bison and cattle. Animal Genetics 36:511 – 542. Solomon K.M., N.D. Halbert, D.T. Redden, D.B. Allison, J.N. Derr. 2006. Marker genotypes, population admixture, and their association with body weight, height, and relative body mass in U.S. federal bison herds. Genetics 174:775-783. Freese, C.H., K. E. Aune, D.P. Boyd, J. N. Derr, S.C. Forrest, C.C. Gates, PJ.P. Gogan, S.M. Grassel, N.D. Halbert, K. Kunkel and K.H. Redford. 2007. Second Chance for the plains bison. Biological Conservation 136(2):175-184. Halbert, N., and J. Derr. 2007. A Comprehensive Evaluation of Cattle Introgression into U.S. Federal Bison Herds. Journal of Heredity 98(1):1-12. Vogel, A.B., K. Tenggardjaja, S. Edmands, N.D. Halbert, J.N. Derr, and D. Hedgecock. 2007. Introgression of cattle mtDNA into Santa Catalina Island American bison. Animal Genetics 38: 410 – 412 Halbert, N., P. Gogan, R. Hiebert, and J. Derr. 2007. Where the buffalo roam: federal bison history and role in species conservation. National Park Service. Park Science 24 :(2) 22-29. Seabury, C., J. E. Womack, C. A. Gill, J. B. Dyar, J. W. Templeton, D. L. Adelson, K. E. Owens, J. N. Derr, D. C. Kraemer. 2007. Molecular characterization of the Rocky Mountain Elk (Cervus elaphus nelsoni) PRNP putative promoter. Journal of Heredity. 98(7): 678-686. Osterstock, J., G. Fosgate, J. Derr, N. Cohen and A. Roussel. 2008. Assessing familial aggregation of paratuberculosis in beef cattle of unknown pedigree. Preventive Veterinary Medicine. 84: 121-134. Osterstock, JB; Fosgate, GT; Cohen, ND; Derr, JN; Manning, EJB; Collins, MT; Roussel, AJ. 2008. Familial associations with paratuberculosis ELISA Results in Texas Longhorn cattle. Veterinary Microbiology.129 (1-2), 131-138. Sanderson, E., K. Redford, B. Weber, K. Aune, D. Baldes, J. Berger, D. Carter, C. Curtin, J. Derr, S. Dobrott, E. Fearn, C. Fleener, S. Forrest, C. Gerlach, j C.C. Gates, J. Gross, P. Gogan, S. Grassel, J. Hilty, M. Jensen, K. Kunkel, D. Lammers, R. List, K. Minkowski, T. Olson, C. Pague, P. Robertson, and B. Stephenson. 2008. The Ecological Future of the North American Bison: Conceiving long-term, large-scale conservation of a species. Conservation Biology 22(2): 252 – 266. Osterstock, JB., G T Fosgate, N D Cohen, J N Derr, A J Roussel. 2008. Familial and herd-level associations with paratuberculosis ELISA status in beef cattle. Journal of Animal Science. 2008 May 9. Halbert, N.D., J.N. Derr (2008) Patterns of genetic variation in U.S. federal bison herds. Molecular Ecology (in press). Douglas, K.C., N.D. Halbert, C.Kolinda, C. Childers, D.L. Hunter and J.N. Derr. 2010. Complete Mitochondrial DNA Sequence Analysis of Bison bison A Bison-Cattle Hybrids: Function and Phylogeny. Mitochondrion. 11. 166-175. Halbert, N.D. J.P. Gogan, P.W. Hedrick, J.M. Wahl and J.N. Derr. 2012. Genetic population substructure in bison at Yellowstone National Park. Journal of Heredity. 103(3):360-370. Derr, J.N., P. W. Hedrick, N.D. Halbert, L. Plough, L.K. Dobson, J. King, C. Duncan, D.L. Hunter,

N.D. Cohen, D. Hedgecock. 2012. Phenotypic Effects of Cattle Mitochondrial DNA in American Bison. Conservation Biology 26(6):1130 – 1136. Halbert, N.D. J.P. Gogan, P.W. Hedrick, J.M. Wahl and J.N. Derr. 2012. Yellowstone Bison Genetics - Let us Move Forward. J Hered first published online August 21, 2012 doi:10.1093/jhered/ess051 Raudsepp, T., McCue, M.M., Das, P.J., Dobson, L., Vishnoi, M., Fritz, K.L., Schaefer, R., Rendahl, A.K., Derr, J.N., Love, C.C., Varner, D.D., Chowdhary, B.P. 2012. Genome-Wide Association Study Implicates Testis-Sperm Specific FKBP6 as a Susceptibility Locus for Impaired Acrosome Reaction in Stallions. PLoS GENETICS, Dec; 8(12):e1003139. Epub 2012 Dec 20. Cronin, M.A., M.D. MacNeil, N. Vu, V. Leesburg, H.D. Blackburn, and J.N. Derr. 2013. Genetic variation and differentiation of bison (Bison bison) subspecies and cattle (Bos taurus) breeds and subspecies. J Hered first published online May, 2012 doi:10.1093/jhered/ess030. Su, H., J. McKelvey, D. Rollins, M. Zhang, D. J. Brightsmith, J. Derr, and S. Zhang. 2014. Cultivable Bacterial Microbiota of Northern Bobwhite (Colinus virginianus): A New Reservoir of Antimicrobial Resistance? PLoS ONE 9:e99826.

Tri Duong, Ph.D. 101 Kleberg Center, TAMU 2472 College Station, TX 77843 Scopus Author ID: 8310874400

EDUCATION

2001 B.S., Biochemistry and Molecular BiologyPennsylvania State University, University Park, PA

2008 Ph.D., Functional Genomics, Biotechnology Minor North Carolina State University, Raleigh, NC

2009 Post-Doctoral Fellowship, Molecular Pathogenesis Washington State University, Pullman, WA

PROFESSIONAL EXPERIENCE

2000 Research Co-op Intern, Research and Development- Technologies McNeil Consumer and Specialty Pharmaceuticals, Fort Washington, PA

2001 Teaching Assistant, Department of Chemistry Pennsylvania State University, University Park, PA

2001 Research Intern, Genomics Core Facility Wistar Institute, Philadelphia, PA

2002 Research Technician, Genomics Core Facility Wistar Institute, Philadelphia, PA

2002 – 2007 Graduate Research Assistant, Department of Food Science North Carolina State University, Raleigh, NC

2008 – 2009 Postdoctoral Research Associate, School of Molecular Biosciences Washington State University, Pullman, WA

2009 - Present Assistant Professor, Department of Poultry Science Texas A&M University, College Station, TX

PUBLICATIONS

Journal Articles:

1. Altermann, E., W.M. Russell, M.A. Azcarate-Peril, R. Barrangou, B.L. Buck, O. McAuliffe, N.Souther, A. Dobson, T. Duong, M. Callanan, S. Lick, A. Hamrick, R. Cano, and T.R. Klaenhammer.2005. Complete genome sequence of the probiotic lactic acid bacterium Lactobacillusacidophilus NCFM. Proc Natl Acad Sci U S A 102:3906-3912.

2. Klaenhammer, T.R., A. Azcarate-Peril, R. Barrangou, T. Duong, and E. Altermann. 2005. GenomicPerspectives on Probiotic Lactic Acid Bacteria. Bioscience Microflora 24:31-33.

3. Duong, T., R. Barrangou, W.M. Russell, and T.R. Klaenhammer. 2006. Characterization of the trelocus and analysis of trehalose cryoprotection in Lactobacillus acidophilus NCFM. Appl EnvironMicrobiol 72:1218-1225.

4. Barrangou, R., M.A. Azcarate-Peril, T. Duong, S.B. Conners, R.M. Kelly, and T.R. Klaenhammer.2006. Global analysis of carbohydrate utilization by Lactobacillus acidophilus using cDNAmicroarrays. Proc Natl Acad Sci U S A 103:3816-3821.

5. Azcarate-Peril, M.A., E. Altermann, Y.J. Goh, R. Tallon, R.B. Sanozky-Dawes, E.A. Pfeiler, S.O'Flaherty, B.L. Buck, A. Dobson, T. Duong, M.J. Miller, R. Barrangou, and T.R. Klaenhammer.2008. Analysis of the genome sequence of Lactobacillus gasseri ATCC 33323 reveals themolecular basis of an autochthonous intestinal organism. Appl Environ Microbiol 74:4610-4625.

6. Klaenhammer, T.R., E. Altermann, E. Pfeiler, B.L. Buck, Y.J. Goh, S. O'Flaherty, R. Barrangou, andT. Duong. 2008. Functional genomics of probiotic lactobacilli. J Clin Gastroenterol. 42 Suppl 3 Pt2:S160-2.

7. Mohamadzadeh, M., T. Duong, T. Hoover, and T.R. Klaenhammer. 2008. Targeting mucosaldendritic cells with microbial antigens from probiotic lactic acid bacteria. Expert Rev Vaccines7:163-74.

8. Mohamadzadeh, M., T. Duong, S.J. Sandwick, T. Hoover, and T.R. Klaenhammer. 2009. Dendriticcell targeting of Bacillus anthracis protective antigen expressed by Lactobacillus acidophilusprotects mice from lethal challenge. Proc Natl Acad Sci U S A 106:4331-36.

9. Duong, T., and M.E. Konkel. 2009. Comparative studies of Campylobacter jejuni genomicdiversity reveal the importance of core and dispensable genes in the biology of this enigmaticfood-borne pathogen. Curr Opin Biotechnol 20:158-165.

10. Klein, M., M.E. Sanders, T. Duong, and H.A. Young. 2010. Probiotics: From Bench to Market.Annals of the New York Academy of Sciences 1212:E1-E14.

11. McFarland, A.P., R. Savan, S. Wagage, A. Addison, K. Ramakrishnan, M. Karwan, T. Duong, andH.A. Young. 2011. Localized Delivery of Interferon-β by Lactobacillus Exacerbates ExperimentalColitis. PLOS One 6:e16967.

12. Duong, T., M. J. Miller, R. Barrangou, M. A. Azcarate-Peril, and T. R. Klaenhammer. 2011.Construction of vectors for inducible and constitutive gene expression in Lactobacillus. MicrobBiotechnol 4:357-367.

13. Cálix-Lara, T.F., T. Duong, and T.M. Taylor. 2012. Addition of a surfactant to tryptic soy brothallows growth of a Lactic Acid Bacteria food antimicrobial, Escherichia coli O157:H7, andSalmonella enterica. Lett Appl Microbiol 54:392-397.

14. Neal-McKinney, J.M., X. Lu, T. Duong, C.L. Larson, D.R. Call, D.H. Shah, and M.E. Konkel. 2012.Production of organic acids by probiotic lactobacilli can be used to reduce pathogen load inpoultry. PLOS One 7:e43928.

15. Menon, R., M. Shields, T. Duong, and J.M. Sturino. 2013. Development of a carbohydrate-supplemented semidefined medium for the semiselective cultivation of Lactobacillus spp. LettAppl Microbiol 57:249-257.

16. Askelson, T.E., A. Campasino, J.T. Lee, and T. Duong. 2014. Evaluation of phytate-degradingLactobacillus administration in broiler chickens. Appl Environ Microbiol 80:943-950.

Program Director/Principal Investigator: FUCHS-YOUNG, Robin


BIOGRAPHICAL SKETCH NAME

Fuchs-Young, Robin POSITION TITLE Professor

eRA COMMONS USER NAME (credential, e.g., agency login) ROBINFY EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)


Emory University, Atlanta, GA B.S. 1978 Biology/English Vanderbilt University, Nashville, TN Ph.D. 1988 Pathology University of Chicago, Chicago, IL (Ben May Institute) Post-doc 1988-1991 Biology of Breast Cancer

A. Personal Statement Dr. Fuchs-Young brings over 25 years of experience in investigations of the basic mechanisms of mammary tumorigenesis. Her research focuses on interacting signaling networks involving the estrogen receptor (ERα), p53 and IGF-1 and includes studies of the impact of energy balance and refined carbohydrates on breast cancer susceptibility. Studies in her lab use a broad array of in vitro and in vivo models, including mammary epithelial and breast cancer cells and genetically modified animals. Using a unique transgenic model of IGF-1 overexpression, she and her team recently reported that developmentally regulated, nongenomic (membrane and cytoplasmic) ERα actions determine the impact of IGF-1 on normal and transformed mammary epithelium and susceptibility to mammary carcinogenesis. Dr. Fuchs-Young’s laboratory also studies breast cancer health disparities and the bio-physiological mechanisms underlying disproportionately poor cancer outcomes in women of color. Dr. Fuchs-Young has also directed a community outreach and engagement program for over 15 years. She has developed and implemented a wide variety of high impact programs providing science education and career development for K-16 students, particularly underrepresented minorities in science, and professional development for K-12 teachers. The goal of these programs is to enhance preparation for and stimulate excitement about careers in EHS, medicine and technology. Her community engagement efforts are also aimed at enhancing EHS literacy and promoting community capacity to achieve environmental justice.

B. Positions and Honors. Research and Professional Experience: 1991-1992 Research Associate, Ben May Institute, University of Chicago, Chicago IL 1992-1996 Senior Scientist, Endocrine Research, Lilly Research Laboratories, Indianapolis IN 1996-2003 Assistant Professor, Department of Carcinogenesis, Science Park - Research Division (SPRD), The

University of Texas MD Anderson Cancer Center (UT MDACC), Smithville TX 2004-2011 Associate Professor, Department of Carcinogenesis, SPRD, UT MDACC 2011-2012 Professor, Department of Molecular Carcinogenesis, SPRD, UT MDACC 2012-pres. Professor, Department of Molecular and Cellular Medicine, College of Medicine and the Institute for Bioscience and Technology (IBT), Texas A&M Health Science Center, TAMU Patents: US Patent #5604248 Method for minimizing the utertrophic effect of tamoxifen and tamoxifen analogs. Issue:

2/18/97 US Patent #5658931 Method for inhibiting mammalian breast carcinoma with tamoxifen and analogs thereof, and certain naphthyl compounds. Issue: 8/19/97 C. Selected peer-reviewed publications or manuscripts in press (relevant to this proposal). 1. Hodges LC, Hunter DS, Bergerson JS, Fuchs-Young R and Walker CL. An in vivo/in vitro model to assess

endocrine disrupting activity of xenoestrogens in uterine leiomyoma. Ann NY Acad Sci, 948:100-111, 2001. 2. Hodges LC, Houston KD, Hunter DS, Fuchs-Young R, Zhang ZM, Wineker RC, Walker CL. Transdominant suppression of estrogen receptor signaling by progesterone receptor ligands in uterine leiomyoma cells. Mol Cell Endocrinol 196 (1-2): 11-20, 2002. 3. Yakar S, Nunez N, Pennisi P, Brodt P, Fallavollita L, Sun H, Stannard B, East-Palmer J, Scavo L, Smith N, Perkins S, Fuchs-Young R, Barrett JC, Hursting SD, LeRoith D. Increased tumor growth in mice with diet- induced obesity: Impact of ovarian hormones. Endocrinology 147: 5826-34, 2006.

Program Director/Principal Investigator: Houston, Kevin


4. de Ostrovich KK, Lambertz I, Colby J, Tian J, Rundhaug J, Johnston D, Conti CJ, DiGiovanni J and Fuchs-Young R. Paracrine overexpression of IGF-1 enhances mammary tumorigenesis in vivo, Am J Path173(3): 824-34, 2008, PMCID: PMC2527085.

5. Harkey SH, Rundhaug J, Tian J, Cullinan-Ammann N, Lambertz I, Conti CJ and Fuchs-Young R. “Transcriptional Regulation of Estrogen Receptor-a by p53 in Human Breast Cancer Cells. Cancer Res, 69(8): 3405-14, 2009, PMCID: PMC Journal-In Process.

6. Sullivan J, Parras, B, St. Marie R, Subra W, Petronella S, Gorenstein J, Fuchs-Young R, Santa RK, Chavarria A, Ward J, and Diamond P. Public Talks and Science Listens: A Community-Based Participatory Approach to Characterizing Environmental Health Risk Perceptions and Assessing Recovery needs in the Wake of Hurricanes Katrina and Rita. Environmental Health Insights, 3: 37-51, 2009.

7. Colbert JH, Westerlind KC, Perkins SN, Haines DC, Berrigan D, Donehower LA, Fuchs-Young R and Hursting SD. Exercise Effects on Tumorigenesis in a Transgenic Mouse Model of Breast Cancer. Med Science Sports Exercise, 41(8): 1597-605, 2009, PMCID: PMC Journal-In Process.

8. King D, Miranda P, Gor B, Fuchs-Young R, Chilton J, Hajek R, Torres-Vigil I, Hernández MA, Snipes SA, Jones L. Addressing cancer health disparities using a global biopsychosocial approach. Cancer, 116(2):264-9, 2010.

9. Fuchs-Young R, Shirley SH, Lambertz I, Colby J, Tian J, Johnston D, Gimenez-Conti I, Donehower LA, Conti CJ, and Hursting SD. P53 genotype as a determinant of ER expression and tamoxifen response in the MMTV-Wnt-1 model of mammary carcinogenesis. Breast Cancer Res Treat, 130(2):399-408, 2011. PMCID: PMC3202603.

10. Tian, J, Lambertz I, Berton TR, Rundhaug JE, Kiguchi K, Shirley SH, DiGiovanni J, Conti CJ, Fischer SM, and Fuchs-Young R. Transgenic Insulin-like Growth Factor-1 Stimulates Activation of COX-2 Signaling in Mammary Glands. Mol Carcinog, 51(12):973-983, 2012.

11. Tian J, Berton TR, Shirley SH, Lambertz I, Gimenez-Conti IB, DiGiovanni J, Korach KS, Conti CJ, and Fuchs-Young R. Developmental stage determines estrogen receptor alpha expression and non-genomic mechanisms that control IGF-1 signaling and mammary proliferation in mice. J Clin Invest, 122(1):192-204, 2012. PMCID: PMC3248275.

D. Current Research and Outreach Support R01MD006228 (Fuchs-Young, PI) 03/01/11–02/29/16 1.44 calendar month NIH/NIMHHD $250,000 Role of p53 polymorphisms in disparities in breast carcinogenesis and outcome. This project will investigate the role of racially disparate p53 polymorphisms in mediating the lack of pregnancy protection and increased susceptibility of minority women to early onset breast cancer.

RP130639 (Shippen, Fuchs-Young, Co-PIs) 12/1/13-11/31/15 0.6 Calendar Months CPRIT $100,000 A role for non-coding RNA in the regulation of telomerase in breast cancer. Specific aims are: 1. To examine the effect of DNA damage on telomerase enzyme activity in mammary cancer cell lines. 2. To identify DNA damage-induced non-coding RNAs that associate with human telomerase. 3. To investigate the expression profile and biochemical interactions of TERT-associated non-coding RNAs.

BC123455 (Fuchs-Young, PI) 09/01/13 – 08/31/15 1.2 Calendar Months DOD/BCRP – IDEA Expansion Undoing the damage: reprogramming the effects of early high sugar/high fat diets through exercise. This project will investigate the potential of exercise to counteract the effects of exposure to hyperinsulinemia/hyperglycemia-inducing diet, during early development, by changing the “metabolic programming” induced by these early dietary exposures. P30 ES023512 (Walker, C., PI) 4/2014-3/2018 2.6 Calendar Months NIEHS/NIH Center for Translational Environmental Health Research (CTEHR). The goal of this project is to develop a Center to support environmental health research projects at Texas A&M. Role: Director of the Community Outreach and Engagement Core; Co-director, Career Development Program. Training Grants NIH/NCI R25T (PI: R. Carroll) 8/1/11 – 7/31/16 unspecified effort Post-doc in Nutrition, biostatistics and bioinformatics $2,467,870 direct costs/5 years Role: Faculty Mentor

BARBARA GASTEL Mailing Address: Telephone Numbers: Department of Veterinary Integrative Biosciences (979) 845-6887 (office) 107 Veterinary Medicine Administration Building (979) 731-8781 (home) 4458 TAMU Fax: (979) 847-8981 College Station, TX 77843-4458 USA E-Mail: [email protected] Degrees MD, 1978, Johns Hopkins MPH, 1978, Johns Hopkins BA, 1974, Yale, summa cum laude (major: biology/history of medicine) Honors Texas A&M University Bush Excellence Award for Faculty in Public Service, 2015 Texas A&M University Association of Former Students Distinguished Achievement Award in Extension, Outreach, Continuing Education, or Professional Development, 2012 John P. McGovern Science and Society Award, Sigma Xi, The Scientific Research Society, 2010 Council of Science Editors Award for Meritorious Achievement, 2010 Honored Editor in the Life Sciences, Board of Editors in the Life Sciences, 2006 John P. McGovern Award for Excellence in the Field of Medical Communications, American Medical Writers Association Southwest Chapter, 2006 Outstanding Texas A&M Science Communicator, Texas A&M University Chapter of Sigma Xi, 2003 Distinguished Service Award, Council of Science Editors, 2002 Fellow, American Association for the Advancement of Science, elected 2001 Harold Swanberg Distinguished Service Award, American Medical Writers Association, 1998 Golden Apple Award, American Medical Writers Association, 1993 Fellow, American Medical Writers Association, elected 1991 Phi Beta Kappa, 1973 Academic and Related Employment 2008- Professor of Veterinary Integrative Biosciences and of Humanities in Medicine Texas A&M University 2004-2008 Associate Professor of Veterinary Integrative Biosciences and of Humanities in Medicine Texas A&M University 1989-2004 Associate Professor of Journalism and of Humanities in Medicine Texas A&M University 1985-1989 Assistant Dean for Teaching and Teaching Evaluation and Assistant Adjunct Professor of Epidemiology and International Health University of California, San Francisco School of Medicine 1983-1985 Visiting Professor of Technical Communication Beijing Medical University (now Peking University Health Science Center) 1981-1983 Assistant Professor of Science Writing Massachusetts Institute of Technology 1980-1981 Special Assistant to the Director National Center for Health Care Technology US Department of Health and Human Services 1978-1980 Special Assistant, Office of the Director National Institute on Aging, National Institutes of Health

Editorial and Related Posts 2013- INASP Associate, AuthorAID (international project to help researchers in developing

countries to write about and publish their work, www.authoraid.info) 2007-2013 Knowledge Community Editor, AuthorAID 2000-2010 Editor, Science Editor (periodical of the Council of Science Editors) 1998-1999 Editor, CBE Views (periodical of the Council of Biology Editors) 1988-1997 Consulting Editor in Medicine and Pathology,

McGraw-Hill Yearbook of Science and Technology 1987-1996 Consulting Editor in Medicine and Pathology,

McGraw-Hill Encyclopedia of Science and Technology 1993-1995 Associate Editor, Sciphers (newsletter, Science Communication Interest Group,

Association for Education in Journalism and Mass Communication) 1987-1994 Member, Editorial Board, CBE Views

(book review editor, 1992-94) 1987-1990 Book Review Editor, American Journal of Preventive Medicine 1983-1985 Editorial Consultant, Chinese Medical Journal 1976-1982 Assistant Editor, Johns Hopkins Medical Journal

(clinical conferences editor, 1977-78; book review editor, 1980-82)

Teaching

Summary of Courses Taught Texas A&M University Science Journalism Graduate Program

Biomedical Reporting Issues in Science and Technology Journalism Reporting Science and Technology Research Methods in Science and Technology Journalism Risk and Crisis Reporting Science Editing

Biomedical Sciences Undergraduate Program Biomedical Explorations Through Narrative Biomedical Writing

Texas A&M Health Science Center College of Medicine Department of Humanities in Medicine Cultural Diversity in Medicine Medical Essays: Current and Classic Medicine and Literature Medicine and the Media Introduction to Medical Ethics (discussion leader and occasional lecturer) Introduction to Leadership in Medicine (discussion leader)

College of Liberal Arts Honors Program Journal Editing and Publication: A Look Behind the Scenes Medical Literacy Through Narrative Physicians’ Recollections Words and Health

http://www.authoraid.info/

Department of Journalism Editing for the Mass Media Magazine Editing and Production Magazine Writing Media Writing II/Reporting and Editing II Methods of Specialized Journalism

University of California, San Francisco School of Medicine Teaching Techniques Scientific Writing Journalism for Health Science Students Fundamentals of Epidemiology (discussion leader) Medical Problem Solving (discussion leader) Introduction to Clinical Medicine (discussion leader)

Beijing Medical University (now Peking University Health Science Center) Scientific Communication American-Style Teaching Methods

Capital (Peking Union) Medical College Scientific Communication

Chinese Medical Association Scientific Communication for Editors

Massachusetts Institute of Technology Science Writing for the Public Scientific and Engineering Writing The Scientific Essay

Recent Workshops for International Researchers AuthorAID Workshops on Research Writing: Dar es Salaam, Tanzania, 5 March 2014; Addis Ababa, Ethiopia, 28-29 November 2012; Nairobi, Kenya, 4-6 June 2012; Lahore, Pakistan, 29 April-1 May 2012; Accra, Ghana, 24-25 November 2011; Kathmandu, Nepal, 14-17 March 2011; Dar es Salaam, Tanzania, 21-24 June 2010; Kandy, Sri Lanka, 15-19 March 2010; Dhaka, Bangladesh,17-21 May 2009; Butare, Rwanda, 23-26 February 2009; Managua, Nicaragua, 24-27 November 2008; Addis Ababa, Ethiopia, 8-9 March 2008 AuthorAID Workshop on Teaching Research Communication: Colombo, Sri Lanka, 27-31 May 2013 AuthorAID Workshop on Effective Mentorship in Research Communication: Colombo, Sri Lanka, 3-4 March 2015 AuthorAID Train the Trainers Workshops on Teaching Research Writing: Addis Ababa, Ethiopia, 30 November 2012; Kathmandu, Nepal, 18 March 2011; Dar es Salaam, Tanzania, 25 June 2010 AuthorAID Workshops on Proposal Writing: Addis Ababa, Ethiopia, 14-17 May 2012; Butare, Rwanda, 7-10 June 2011 AuthorAID/University of Colombo Faculty of Medicine Workshop for Research Trainers, Colombo, Sri Lanka, 3-4 March 2015 Health Reporting Workshop for Health Professionals and Journalists, Accra, Ghana, 21-22 November 2011 (co-facilitator) Intensive Course in Research Writing, Texas A&M University: 23 June-11 July 2014; 24 June-12 July 2013; 25 June-13 July 2012; 27 June-15 July 2011; 5-23 July 2010; 22 June-10 July 2009; 7-25 July 2008 International Training Workshops: Revision of Research Proposals and Development of

Scientific Manuscripts for Publication (led the portion on scientific manuscripts): Cali, Colombia, 9-14 November 2009; Nairobi, Kenya, 29 April-4 May 2008 Lecture Series on Biomedical Writing and Scientific Publication, Sichuan University, Chengdu, China, 24-26 December 2007 (one of two main lecturers) Scientific-Communication Capacity-Building Workshop, Nairobi, Kenya, 7-8 May 2015 Scientific-Communication Workshop, Havana, Cuba, 13-14 October 2014 Workshop on Medical Writing and Publication, Bangladesh Society of Medicine, Dhaka, Bangladesh, 10-14 December 2011 Workshop on Scientific Writing and Publishing, Makerere University, Kampala, Uganda, 13-17 August 2007 Workshops in Mexico on Scientific Writing: Mexico City, 25-27 November 2009; Monterrey, 10-12 September 2009; Torreón, 16-20 March 2009

Workshops at American Medical Writers Association Annual Conferences Medical Journalism: From Choosing a Topic Through Polishing the Piece: 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2011, 2012, 2013, 2014 Journal Submissions Other Than Scientific Papers: 1989, 1990, 1991, 1997, 2000, 2001, 2002, 2003, 2005, 2006, 2007, 2008, 2011, 2012

The Elements of Medical Terminology: 1998, 1999, 2000, 2001, 2004, 2006, 2007, 2012, 2013, 2014 Teaching Techniques: Theory and Practice: 1987, 1988, 1989, 1990, 1991, 1992, 1993, 1994, 1996, 1998, 1999, 2000, 2001, 2002, 2003, 2004, 2005 Medical Mysteries/Science Through Suspense: 1996, 1997 Medical Essays: 1995 Teaching Medical Journalism: 1993, 1994 How to Teach Medical Writing for the Lay Readership: 1992

Selected Other Teaching-Related Activities Master's Degree Program in Science and Technology Journalism, Texas A&M University:

Coordinator, 1995-1999, 2004- Chair of Graduate Advisory Committees of about 50 Students, 1996-

China Medical Board Program in Biomedical Writing and Editing, 1996-2007 Principal Consultant/US Coordinator Instructor: Intensive Course and Online Lessons Internship Placement Coordinator and Internship Host

Science Editor Magazine, 2000-2010 Supervisor of Interns

Teaching Grants University Scholars Mentorship Grants, Honors Program, Texas A&M University,

Spring and Fall 2006 and Spring 2007 ($500 per semester) College of Liberal Arts Honors Course Grant, Texas A&M University, 2005 ($1,000) Honors Curriculum Development Grant, Texas A&M University, 1992 ($2,000)

Teaching Awards and Nominations 2002 Class Friend Award, Class of 2002, Texas A&M College of Medicine 1997 Graduate Student Council Faculty Excellence Award, Texas A&M University 1989 Nomination for teaching award, UCSF School of Medicine

1988 Nomination for teaching award, UCSF School of Medicine 1987 Award for Outstanding Dedication to Quality Teaching,

presented by classes of 1989 and 1990, UCSF School of Medicine

Publications

Books

Day RA, Gastel B. How to Write and Publish a Scientific Paper. 7th edition. Santa Barbara, CA: ABC-CLIO, 2011. (also published thus far in a Chinese edition)

Day RA, Gastel B. How to Write and Publish a Scientific Paper. 6th edition. Westport, CT: Greenwood Press, 2006. (also published in Arabic, Chinese, Japanese, Spanish, and Turkish editions)

Gastel B. Health Writer's Handbook. 2nd edition. Ames, Iowa: Blackwell Publishing, 2005.

Gastel B. Health Writer's Handbook. Ames, Iowa: Iowa State University Press, 1998.

Gastel B. Teaching Science: A Guide for College and Professional School Instructors. Phoenix: Oryx Press, 1991.

Gastel B. Presenting Science to the Public. Philadelphia: ISI Press, 1983.

Self-Study Workshop (Workbook and CD)

Gastel B. Elements of Medical Terminology. Rockville, Maryland: American Medical Writers Association, 2010.

Monographs

Gastel B. Chinese National Meeting on Medical Education and Research: Summary with Context. New York: China Medical Board, 1996.

Gastel B. Working With Your Older Patient: A Clinician's Handbook. Bethesda, MD: National Institute on Aging, National Institutes of Health, 1994.

Volumes Edited

Gastel B, Hallock JA, eds. Impact of International Medical Graduates on U.S. and Global Health Care: Proceedings of the 50th Anniversary Conference of the Educational Commission for Foreign Medical Graduates. Academic Medicine 81 (Supplement to Number 12), 2006.

Gary NE, Boelen C, Gastel B, Ayers WR, eds. Improving the Social Responsiveness of Medical Schools. Academic Medicine 74 (Supplement to Number 8), 1999.

Gastel B, Wilson MP, Boelen C, eds. Toward a Global Consensus on Quality Medical Education:

Serving the Needs of Populations and Individuals. Academic Medicine 70 (Supplement to Number 7), 1995.

Schroeder SA, Schuster BL, Gastel B, eds. New Challenges in Resident Education. Journal of General Internal Medicine 5 (Supplement to Number 1), 1990.

Gastel B, Rogers DE, eds. Clinical Education and the Doctor of Tomorrow. New York: New York Academy of Medicine, 1989.

Liu YC, with Fang TY, Chen LD, translators, and Gastel B, editorial consultant. The Essential Book of Traditional Chinese Medicine. Volume 2: Clinical Practice. New York: Columbia University Press, 1988.

Eliastam M, Gastel B, eds. Technology Assessment Forum on Coronary Artery Bypass Surgery: Economic, Ethical and Social Issues. (American Heart Association Monograph Number 92.) Circulation 66 (Number 5, Part II), 1982.

Gastel B, Haddow JE, Fletcher JC, Neale A, eds. Maternal Serum Alpha-Fetoprotein: Issues in the Prenatal Screening and Diagnosis of Neural Tube Defects. Washington: U.S. Government Printing Office, 1980.

Articles

Selected Articles in Peer-Reviewed Publications

Appiah B, Gastel B, Burdine JN, Russell LH. Science reporting in Accra, Ghana: sources, barriers and motivational factors. Public Understanding of Science 24(1): 23-37, 2015.

Gastel B. AuthorAID: an international service and chance to serve. Medical Writing 22: 284-287, 2013.

Appiah B, Gastel B, Burdine JN, Russell LH. The future of science journalism in Ghana: evidence-based perspectives. Journal of Science Communication 11(1): C04, 2012; 5 pages. Accessible at http://jcom.sissa.it/archive/11/01/Jcom1101(2012)C01/Jcom1101(2012)C04/Jcom1101(2012)C04.pdf. 2012.

Gastel B. Impact of international medical graduates on U.S. and global health care: summary of the ECFMG 50th anniversary international conference. Academic Medicine 81 (Supplement to Number 12): S3-S6, 2006.

Gastel B. Concurrent sessions: exploring issues relating to international medical graduates. Academic Medicine 81 (Supplement to Number 12): S63-S68, 2006.

Gastel B. Hosting a biomedical communication intern: from idea through implementation. AMWA [American Medical Writers Association] Journal 21: 97-101, 2006.

Gastel B. Publishing excellent conference reports: editors and reporters share advice. Science Editor 25: 118-121, 2002.

http://jcom.sissa.it/archive/11/01/Jcom1101(2012)C01/Jcom1101(2012)C04/Jcom1101(2012)C04.pdf

Whalen E, Gastel B. Science editing and caregiving: experience and guidance. Science Editor 24: 114-119, 2001.

Gastel B. 1999 Council of Biology Editors Annual Meeting. [Conference summary.] Serials Review 25(4): 7-10, 1999.

Gastel B. Summer reading for science editors. CBE Views 22: 76-78, 1999.

Gastel B. Improving the social responsiveness of medical schools: summary of the conference. Academic Medicine 74 (Supplement to Number 8): S3-S7, 1999.

Gastel B. Gifts for and from editors: thoughts from CBE members. CBE Views 21: 206-207, 1998.

Gastel B. Medical writers' delegation visits Russia, Estonia. CBE Views 21: 90, 1998.

Gastel B. Teaching key groups to communicate science to nonspecialists. CBE Views 20(3): 82-85, 1997.

Gastel B, Moore JE. Resources on popular science communication. CBE Views 20(3): 96-99, 1997.

Gastel B. Medical writers' visit to China and Mongolia: delegation leader's diary. AMWA Journal 11(2): 19-25, 1996.

Gastel B. Biomedical editing in China and Mongolia: glimpses from a recent visit. CBE Views 19(2): 3-5, 1996.

Gastel B. Toward a global consensus on quality medical education: serving the needs of populations and individuals: summary of the consultation. Academic Medicine 70 (Supplement to Number 7): S3-S7, 1995.

Acuff GR, Albanese RA, Batt CA, Berndt DL, Byers FM, Dale BE, Denton JH, Fuchs RL, Gastel B, Heidelbaugh ND, Ivie GW, Kendall K, Kopchick JJ, Lewis DH, McCasland FV, Menning EL, Phillips TD, Potter ME, Rodricks JV, Scholl DR, Shadduck JA, Tarnowski SJ, Tillotson JE, Van Dresser WR, Womack JE. Implications of biotechnology, risk assessment, and communications for the safety of foods of animal origin. Journal of the American Veterinary Medical Association 199: 1714-1721, 1991.

Gastel B. A strategy for reviewing books for journals. BioScience 41: 635-637, 1991. (Reprinted: CBE Views 16: 50-52, 1993; Plant Science Bulletin 40: 79-81, 1994.)

Gastel B. A menu of approaches for evaluating your teaching. BioScience 41: 342-345, 1991.

Gastel B. An award program for teaching excellence. Academic Medicine 66: 192-193, 1991.

Gastel B. Book reviewing: confessions, commendations, and cravings of an addict. CBE Views 14: 3-6, 1991.

Gastel B, Weng YQ. Medical journals in China. Annals of Internal Medicine 112: 70-72, 1990.

Gastel B. Writing for HMO Practice. HMO Practice 3: 158-160, 1989.

Gastel B. Teaching biomedical communication in China: reflections on two years' experience. CBE Views 10: 19-21, 1987.

Gastel B (with Chien SC, translator). (Article on writing scientific papers.) JAMA (Chinese edition) 6: 309-310, 1987.

Gastel B (with Chien SC, translator). Notes on biomedical communication. 1. Some introductory comments. 2. Writing clearly in English. JAMA (Chinese edition) 5: 66-68, 1986.

Gastel B. Abel and onward: some early history of hemodialysis. Medical Instrumentation 20: 62-64, 1986.

Gastel B, Jaffe ER. Research in hematology: progress and promise. Blood 62: 932-936, 1983.

Gastel B, Cornoni-Huntley J, Brody JA. Estrogen use and postmenopausal women: a basis for informed decisions. Journal of Family Practice 11: 851-860, 1980.

Gastel B, Brody JA. The use of estrogens by postmenopausal women: a review of the issues. Journal of Clinical and Experimental Gerontology 1: 217-229, 1979.

Butler RN, Gastel B. Aging and cancer management. Part II: research perspectives. Ca--A Cancer Journal for Clinicians 29: 333-340, 1979.

Butler RN, Gastel B. Hearing and age: research challenges and the National Institute on Aging. Annals of Otology, Rhinology and Laryngology 88: 676-683, 1979.

Gastel B. Measles: a potentially finite history. Journal of the History of Medicine and Allied Sciences 28: 34-44, 1973.

Selected Other Pieces for Professional Readerships

Gastel B. Alerting students to what’s different about magazine writing. Magazine Matter 30(4): 4, 2012.

Gastel B. Writing and publishing journal articles: from typewriters and postal deliveries to electronic everything. Johns Hopkins Public Health (online extra), Special Issue 2012. Available at: http://magazine.jhsph.edu/2012/technology/online_extras/alumni_dispatches/barbara_gastel/.

Gastel B. Amplifying impact: AuthorAID’s train-the-trainer workshops. INASP Newsletter (44): 2-3, 2011.

Gastel B. Satisfactions of science editing: experienced manuscript editors reflect. Science Editor 34: 47-48, 2011.

CURRICULUM VITAE

I. PERSONAL INFORMATION

Name: Terry Joe GentryTitle: Associate ProfessorAddress: 550A Heep Center

2474 TAMU College Station, TX 77843

Department: Soil and Crop Sciences Date of initial appointment: January 1, 2006

II. EDUCATION

2003-2005 Postdoctoral Research Associate, Oak Ridge National Laboratory 1999-2003 Doctor of Philosophy (Microbiology & Immunology), University of Arizona 1995-1998 Master of Science (Agronomy), University of Arkansas 1988-1993 Bachelor of Science (Agronomy), University of Arkansas

III. EXPERIENCE

2006-Present Assistant/Associate Professor, Department of Soil and Crop Sciences, Texas A&M University

2003-2005 Postdoctoral Research Associate, Environmental Sciences Division, Oak Ridge National Laboratory

1999-2003 Graduate Research/Teaching Associate, Department of Soil, Water, and Environmental Science, University of Arizona

1995-1999 Research Specialist/Graduate Assistant, Department of Crop, Soil, and Environmental Sciences, University of Arkansas

1993-1995 Research Analyst, Agronomy, Agricultural Experiment Station, University of the Virgin Islands

Undergraduate Courses Taught

SCSC 405 – Soil and Water Microbiology, 4 credit hour course offered in fall and spring semesters. Discussion of the roles of soil and water microorganisms in the sustainability and productivity of various ecosystems with specific emphasis on plant-microbial interactions, nutrient cycling, degradation of pesticides and other xenobiotics, generation of trace gases, and soil and water quality. The laboratory portion of the course reinforces these concepts and provides hands-on experience with current techniques in soil and water microbiology.

SCSC 425 (489) - Biofuels and the Environment, 2 credit hour course offered in fall semester of even-numbered years. Stacked with SCSC 625. Discussion of different biofuel crops, production systems, and conversion technologies. Impacts of biofuel cropping systems on sustainability of yields and various aspects of soil and water quality. Environmental issues related to use/disposal of biofuel by-products. Economics and net C and energy budgets for various biofuel production systems.

Curriculum Vitae – Terry J. Gentry

SCSC 455 – Environmental Soil Science, 3 credit hour course offered every spring semester. Stacked with SCSC 657. Environmental aspects of soil receiving organic and inorganic materials involved with crop production and from wastes associated with agriculture, industry and municipalities; soil properties largely determine environmentally sound practices of applying these materials and the quantities that may be added without polluting air, soil and water resources.

Graduate Courses Taught

SCSC 625 (689) - Biofuels and the Environment, 2 credit hour course offered in fall semester of even-numbered years. Stacked with SCSC 425. Discussion of different biofuel crops, production systems, and conversion technologies. Impacts of biofuel cropping systems on sustainability of yields and various aspects of soil and water quality. Environmental issues related to use/disposal of biofuel by-products. Economics and net C and energy budgets for various biofuel production systems.

SCSC 637 (689) - Environmental Microbiology, 3 credit hour course offered in fall semester of odd-numbered years. Microbial diversity and interactions in various environments with emphasis on soil and freshwater systems. Molecular methods for detection and characterization of indigenous and introduced microorganisms. Environmental sources and fate of pathogens. Biotechnological applications of environmental microorganisms.

SCSC 657 (689) – Environmental Soil Science, 3 credit hour course offered every spring semester. Stacked with SCSC 455. Environmental aspects of soil receiving organic and inorganic materials involved with crop production and from wastes associated with agriculture, industry and municipalities; soil properties largely determine environmentally sound practices of applying these materials and the quantities that may be added without polluting air, soil and water resources.

Peer-Reviewed Journal Articles (publications since 2011; out of 55 total articles)

Cardenas, E., W.-M Wu, M.B. Leigh, J. Carley, S. Carroll, T. Gentry, J. Luo, D. Watson, B. Gu, M. Ginder-Vogel, P.K. Kitanidis, P.M. Jardine, J. Zhou, C.S. Criddle, T.L. Marsh. and J.M.Tiedje. 2010. Significant association between sulfate-reducing bacteria and uranium-reducingmicrobial communities as revealed by a combined massively parallel sequencing–indicatorspecies approach. Appl. Environ. Microbiol. 76:6778-6786.

Gao, W., T.J. Gentry, T.L. Mehlhorn, S.L. Carroll, P.M. Jardine, and J. Zhou. 2010. Characterization of Co(III) EDTA-Reducing bacteria in metal- and radionuclide-contaminated groundwater. Geomicrobiology J. 27:93-100.

Gontcharova, V., E. Youn, R.D. Wolcott, E.B. Hollister, T.J. Gentry, and S.E. Dowd. 2010. Black Box Chimera Check (B2C2): a Windows-based software for batch depletion of chimeras from bacterial 16S rRNA gene datasets. Open Microbiol. J. 4:47-52.

Gonzalez-Chavez, M.C.A., J.A. Aitkenhead-Peterson, T.J. Gentry, D. Zuberer, F. Hons, and R. Loeppert. 2010. Soil microbial community, C, N, and P responses to long-term tillage and crop rotations. Soil Till. Res. 106:285-293.

Harmel, R.D., R. Karthikeyan, T. Gentry, and R. Srinivasan. 2010. Effects of agricultural management, land use, and watershed scale on E. coli concentrations in runoff and streamflow. Trans. ASABE 53:1833-1841.


He, Z., Y. Deng, J.D. Van Nostrand, Q. Tu, M. Xu, C.L. Hemme, X. Li, L. Wu, T.J. Gentry, Y. Yin, J. Liebich, T.C. Hazen, and J. Zhou. 2010. GeoChip 3.0 as a high-throughput tool for analyzing microbial community composition, structure, and functional activity. ISME J. 4:1167-1179.

Hemme, C.L., Y. Deng, T.J. Gentry, M.W. Fields, L. Wu, S. Barua, K. Barry, S.G. Tringe, D.B. Watson, Z. He, T.C. Hazen, J.M. Tiedje, E.M. Rubin, and J. Zhou. 2010. Metagenomic insights into evolution of a heavy metal-contaminated groundwater microbial community. ISME J. 4:660-672.

Hollister, E.B., A.S. Engledow, A.J. Hammett, T.L. Provin, H.H. Wilkinson, and T.J. Gentry. 2010. Shifts in microbial community structure along an ecological gradient of hypersaline soils and sediments. ISME J. 4:829-838.

Hollister, E.B., A.K. Forrest, H.H. Wilkinson, D.J. Ebbole, S.A. Malfatti, S.G Tringe, M.T. Holtzapple, and T.J. Gentry. 2010. Structure and dynamics of the microbial communities underlying the carboxylate platform for biofuel production. Appl. Microbiol. Biotechnol. 88:389-399.

Lancaster, S.H., E. Hollister, S.A. Senseman, and T.J. Gentry. 2010. Effects of repeated glyphosate applications on soil microbial community composition and the mineralization of glyphosate. Pest Manag. Sci. 66:59–64.

Pillai, T.R., W. Yan, H.A. Agrama, W.D. James, A.M.H. Ibrahim, A.M. McClung, T.J. Gentry, and R.L. Loeppert. 2010. Total grain-arsenic and arsenic-species concentrations in diverse rice cultivars under flooded conditions. Crop Sci. 50:2065-2075.

Xu, M. W-M. Wu, L. Wu, Z. He, J.D. Van Nostrand, Y. Deng, J. Luo, J. Carley, M. Ginder-Vogel, T.J. Gentry, B. Gu, D. Watson, P.M. Jardine, T.L. Marsh, J.M. Tiedje, T. Hazen, C.S. Criddle, and J. Zhou. 2010. Responses of microbial community functional structures to pilot-scale uranium in situ bioremediation. ISME J. 4:1060-1070.

Golub, K.W., A.D. Smith, E.B. Hollister, T.J. Gentry, and M.T. Holtzapple. 2011. Investigation of intermittent air exposure on four-stage and one-stage anaerobic semi-continuous mixed-acid fermentations. Bioresour. Technol. 102:5066-5075.

Holgate, L.C., J.A. Aitkenhead-Peterson, and T.J. Gentry. 2011. Irrigation water chemistry: Impact on microbial community composition and biogeochemical leaching under perennial ryegrass (Lolium perenne [L.]). ISRN Ecology. Vol 2011; Article ID 797910; 9 p.; doi:10.5402/2011/797910.

Hollister, E., A.J. Hammett, M. Holtzapple, T. Gentry, and H. Wilkinson. 2011. Microbial community composition and dynamics in a semi-industrial-scale facility operating under the MixAlco™ bioconversion platform. J. Appl. Microbiol. 110:587-596.

Hu, P., A.S. Wang, A.S. Engledow, E.B. Hollister, K.L. Rothlisberger, J.E. Matocha, D.A. Zuberer, T.L. Provin, F.M. Hons, and T.J. Gentry. 2011. Inhibition of the germination and growth of Phymatotrichopsis omnivora (Cotton Root Rot) by oilseed meals and isothiocyanates. Appl. Soil Ecol. 49:68-75.

Somenahally, A.S., E.B. Hollister, R.H. Loeppert, W. Yan, and T.J. Gentry. 2011. Microbial communities in rice rhizosphere altered by intermittent and continuous flooding in fields with long-term arsenic application. Soil Biol. Biochem. 43:1220-1228.

Somenahally, A.S., E.B. Hollister, W. Yan, T.J. Gentry, and R.H. Loeppert. 2011. Water management impacts on arsenic speciation and iron-reducing bacteria in contrasting rice-rhizosphere compartments. Environ. Sci. Technol. 45:8328-8335.


Van Nostrand, J.D., L. Wu, W. Wu, Z. Huang, T.J. Gentry, Y. Deng, J. Carley, S. Carroll, Z. He, B. Gu, J. Luo, C.S. Criddle, D.B. Watson, P.M. Jardine, T.L. Marsh, J.M. Tiedje, T.C. Hazen,and J. Zhou. 2011. Dynamics of microbial community composition and function during insitu bioremediation of a uranium-contaminated aquifer. Appl. Environ. Microbiol. 77:3860-3869.

Deng, L., S.A. Senseman, T.J. Gentry, D.A. Zuberer, T.L. Weiss, T.P. Devarenne, and E.R. Camargo. 2012. Effect of selected herbicides on growth and hydrocarbon content of Botryococcus braunii (Race B). Ind. Crops Prod. 39:154-161.

Forrest, A.K., E.B. Hollister, T.J. Gentry, H.H. Wilkinson, and M.T. Holtzapple. 2012. Comparison of mixed-acid fermentations inoculated with six different mixed cultures. Bioresour. Technol. 118:343-349.

Hollister, E.B., A.K. Forrest, H.H. Wilkinson, D.J. Ebbole, S.G. Tringe, S.A. Malfatti, M.T. Holtzapple, and T.J. Gentry. 2012. Mesophilic and thermophilic conditions select for unique but highly parallel microbial communities to perform carboxylate platform biomass conversion. PLoS ONE 7(6): e39689. doi:10.1371/journal.pone.0039689.

Ng, J., E.B. Hollister, M.C.A. González-Chávez, F.M. Hons, D.A. Zuberer, J.A. Aitkenhead-Peterson, R. Loeppert, and T.J. Gentry. 2012. Impacts of cropping systems and long-term tillage on soil microbial population levels and community composition in dryland agricultural setting. ISRN Ecology. Vol 2012; Article ID 487370; 11 pages; doi:10.5402/2012/487370.

Rothlisberger, K.L., F.M. Hons, T.J. Gentry, and S.A. Senseman. 2012. Oilseed meal effects on the emergence and survival of crop and weed species. Appl. Environ. Soil Sci. Vol 2012; Article ID 769357; 10 pages; doi:10.1155/2012/769357.

Wagner, K.L., L.A. Redmon, T.J. Gentry, and R.D. Harmel. 2012. Assessment of cattle grazing effects on E. coli runoff. Trans. ASABE. 55:2111-2122.

Wang, A.S., P. Hu, E.B. Hollister, K.L. Rothlisberger, A. Somenahally, T.L. Provin, F.M. Hons, and T.J. Gentry. 2012. Impact of Indian mustard (Brassica juncea) and flax (Linum

usitatissimum) seed meal applications on soil carbon, nitrogen, and microbial dynamics. Appl. Environ. Soil Sci. Vol 2012; Article ID 351609; 14 p; doi:10.1155/2012/351609.

Harclerode, C., T.J. Gentry, and J.A. Peterson. 2013. A geographical approach to tracking Escherichia coli and other water quality constituents in a Texas coastal plains watershed. Environ. Monit. Assess. 185:4659-4678.

Harmel, R.D., K.L., Wagner, E. Martin, T.J. Gentry, R. Karthikeyan, M. Dozier, and C. Coufal. 2013. Impact of poultry litter application and land use on E. coli runoff from small agricultural watersheds. Biol. Eng. Trans. 6:3-16.

Hollister, E.B., P. Hu, A.S. Wang, F.M. Hons, and T.J. Gentry. 2013. Differential impacts of brassicaceous and non-brassicaceous oilseed meals on soil bacterial and fungal communities. FEMS Microbiol. Ecol. 83:632-641.

McCrary, K.J., C.L. Harclerode Case, T.J. Gentry, and J.A. Aitkenhead-Peterson. 2013. Escherichia coli regrowth in disinfected sewage effluent: effect of DOC and nutrients on regrowth in laboratory incubations and urban streams. Water Air Soil Pollut. 224:1412.

Sullivan, B.A., T. Gentry, and R. Karthikeyan. 2013. Characterization of tetracycline-resistant bacteria in an urbanizing subtropical watershed. J. Appl. Microbiol. 115:774-785.

Wagner, K.L., L.A. Redmon, T.J. Gentry, R.D. Harmel, R. Knight, C.A. Jones, and J.L. Foster. 2013. Effects of an off-stream watering facility on cattle behavior and instream E. coli levels. Texas Water J. 4:1-13.

Program Director/Principal Investigator: GILL, Clare A.

BIOGRAPHICAL SKETCH

NAME Gill, Clare A.

POSITION TITLE Professor

EDUCATION/TRAINING

INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY

Flinders University of South Australia, Australia B.Biot. 1995 Biotechnology

University of Adelaide, Australia Ph.D. 2001 Molecular Genetics

Texas A&M University, College Station, TX Post-doc. 1999 Animal Genomics


Positions and Employment: 1995 - 1998: Graduate Student; University of Adelaide, South Australia, Australia. 1999 - 2000: Post-Doctoral Fellow; Texas A&M University. 2000 - 2001: Associate Research Scientist; Texas A&M University. 2001 - present: Member of the Graduate Faculty, Texas A&M University. 2001 - 2007: Assistant Professor of Animal Genomics; Texas A&M University. 2002 - present: Member of the Interdisciplinary Faculty of Genetics, Texas A&M University. 2003 - present: Member of the Interdisciplinary Faculty of Biotechnology, Texas A&M University. 2007 - 2013: Associate Professor of Animal Genomics; Texas A&M University. 2011 - present: Associate Vice President for Diversity; Texas A&M University. 2013 - present: Professor of Animal Genomics; Texas A&M University. 2013 - present: Faculty Ombuds Officer; Texas A&M University. Professional Memberships and Honors: Memberships: American Society of Animal Science, International Society of Animal Genetics,

Texas Genetics Society, American Association for the Advancement of Science 1995: AMGEN Australia prize for excellence in biotechnology research 1995: Flinders University Chancellor’s letter of commendation 1998 & 1999: Finalist in the Young Australian of the Year Awards: nominated for The SA Water Science and Technology award for outstanding achievement 2009: Vice Chancellor’s Award in Excellence for Research (The McGregor Bovine Genomics Team) 2011: ADVANCE Administrative Fellow Patent: Gill, C. A., B. Woodward, S. Bauck, and N. Voss. 2008. Breed specific haplotypes for

the polled phenotype in cattle. 12/338,835 and PCT/US08/87522. Filed December 18, 2008. Patent 8,105,776 issued, 1/31/12 by US Patent Trademark Office.

B. Selected Peer-Reviewed Publications (2009-2014) 1. Goldammer, T., R. M. Brunner, A. Rebl, C. H. Wu, K. Nomura, T. Hadfield, C. Gill, B. P.

Dalrymple, J. E. Womack, and N. E. Cockett. 2009. A high-resolution radiation hybrid map

Program Director/Principal Investigator: GILL, Clare A.

of sheep chromosome x and comparison with human and cattle. Cytogenet Genome Res 125: 40-45.

2. Kochan, K. J., R. N. Vaughn, T. S. Amen, C. A. Abbey, J. O. Sanders, D. K. Lunt, A. D. Herring, J. E. Sawyer, C. A. Gill, and P. K. Riggs. 2009. Expression of mitochondrial respiratory complex genes in liver tissue of cattle with different feed efficiency phenotypes. Proc. Assoc. Advmt. Anim. Breed. Genet. 18: 175-178.

3. Smith, S. B., C. A. Gill, D. K. Lunt, and M. A. Brooks. 2009. Regulation of fat and fatty acid composition in beef cattle. Asian-Aust. J. Anim. Sci. 22: 1225-1233.

4. The Bovine Genome Sequencing and Analysis Consortium. 2009. The genome sequence of taurine cattle: A window to ruminant biology and evolution. Science 324: 522-528.

5. The Bovine HapMap Consortium. 2009. Genome-wide survey of snp variation uncovers the genetic structure of cattle breeds. Science 324: 528-532.

6. *Villa-Angulo, R., L. Matukumalli, C. Gill, J. Choi, C. Van Tassell, and J. Grefenstette. 2009. High-resolution haplotype block structure in the cattle genome. BMC Genetics 10: 19.

7. Riggs, P. K., and C. A. Gill. 2009. Molecular mapping and marker-assisted breeding for muscle growth and meat quality. In: Applied Muscle Biology and Meat Science, M. Du and R. J. McCormick, eds. CRC press.

8. *Stafuzza, N. B., C. A. Abbey, C. A. Gill, J. E. Womack, and M. E. J. Amaral. 2012. Construction and preliminary characterization of a river buffalo bacterial artificial chromosome library. Genet. Mol. Res. 11: 3013-3019.

9. Brinkmeyer-Langford, C. L., J. J. Cai, C. A. Gill, L. C. Skow. 2013. Microsatellite variation in the equine MHC. Anim. Genet. 44:267-275.

10. *Stafuzza, N. B., A. J. Greco, J. R. Grant, C. A. Abbey, C. A. Gill, T. Raudsepp, L. C. Skow, J. E. Womack, P. K. Riggs, and M. E. J. Amaral. 2013. A high-resolution radiation hybrid map of the river buffalo major histocompatibility complex and comparison with BoLA. Anim. Genet. 44:369-376.

11. Riley, D. G., T. H. Welsh, Jr., C. A. Gill, A. D. Herring, P. K. Riggs, J. E. Sawyer, and J. O. Sanders. 2013. Whole genome association of SNP with newborn calf cannon bone length. Livestock Sci. 155: 186-196.

12. *†Hulsman Hanna, L. L., J. O. Sanders, D. G. Riley, C. A. Abbey, and C. A. Gill. 2014. Identification of a major locus interacting with MC1R and modifying black coat color in an F2 Nellore-Angus population. Gen. Sel. Evol. 46:4. Highly Accessed.

13. *Hulsman Hanna, L. L., D. J. Garrick, C. A. Gill, A. D. Herring, P. K. Riggs, R. K. Miller, J. O. Sanders, and D. G. Riley. 2014. Genome-wide association study of temperament and tenderness using different Bayesian approaches in a Nellore-Angus crossbred population. Livestock Sci. 161: 17-27.

14. *Ingram, C. M., N. J. Troendle, C. A. Gill, and R. L. Honeycutt. 2014. Characterization of 12 new microsatellite markers for the naked mole-rate, Heterocephalus glaber. Conserv. Genet. Resour. doi:10.1007/s12686-014-0147-2 Epub ahead of print.

* Graduate student as first author

*† Graduate student that I advised as first author




NAME Melissa A. Grunlan


eRA COMMONS USER NAME mgrunlan EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)


North Dakota State University B.S. 1991-1995 Chemistry North Dakota State University M.S. 1995-1997 Polymers & Coatings University of Southern California Ph.D. 2001-2004 Chemistry Texas A&M University Post-doc 2004-2005 Chemistry

A. Personal Statement The PI is an Associate Professor in the Department of Biomedical Engineering at Texas A&M University (TAMU). She is the author of 39 journal articles in press. Dr. Grunlan received her Ph.D. training in silicon polymer chemistry with Prof. Bill Weber (USC). She specializes in the synthesis and fabrication of silicon-based polymeric materials including coatings, shape memory polymers and hydrogels. These materials are directed towards improving the performance of tissue-contacting devices (e.g. hemodialysis catheter and subcutaneously implanted glucose biosensors) as well the guiding the regeneration of osteochondral tissues. Dr. Grunlan has been involved with numerous training/mentoring activities with graduate and undergraduate students in Biomedical Engineering and Materials Science & Engineering at TAMU. To date, she has advised 12 Ph.D. students (7 graduated), 1 M.S. student (1 graduated) and 42 undergraduate students (currently 9). In addition, she has co-chaired 2 Ph.D. students (1 graduated). In addition, 1 post-doc will start ~January 2015. Her students train in cross-cutting research including collaborations with science, engineering and clinical researchers. These students are mentored through weekly research meetings as well as with activities including manuscript and grant preparation as well as conference participation. Senior students are also afforded opportunities to train as mentors themselves by mentoring undergraduate student researchers. This system has notable produced 18 (out of 42) undergraduate students as co-authors of a journal article and numerous students who have presented at national &/or local conferences. B. Positions and Honors Positions and Employment 1997-2001 Senior Chemist, The H.B. Fuller Company (St. Paul, MN) 2004-2005 Post-doctoral research associate, Dept. of Chemistry, Texas A&M University (College Station, TX) 2005-2011 Assist. Professor, Dept. of Biomedical Engineering, Texas A&M University (College Station, TX) 2011- date Assoc. Professor, Dept. of Biomedical Engineering, Texas A&M University (College Station, TX) Other Experience and Professional Memberships 1997- American Chemical Society (ACS) 2007- Materials Research Society (MRS) 2009- Society for Biomaterials (SFB) Selected Honors & Awards 2001 Quarterly Technical Achievement Award, The H.B. Fuller Company 2005 Doctoral Dissertation Award, University of Southern California 2010 The Association of Former Students (AFS) Teaching Award, Texas A&M University 2010-2011 Herbert H. Richardson Fellow, Texas A&M University 2012-2013 British Petroleum (BP) Teaching Excellence Award, Texas A&M University 2013 Texas A&M Engineering Experiment Station (TEES) Faculty Fellow


C. Selected peer-reviewed publications (in chronological order; selected from 39 peer-reviewed publications in press).

Most relevant to current application 1. Munoz-Pinto, D.J.; McMahon, R.E.; Kanzelberger, M.A.; Jimenez-Vergara, A.C.; Grunlan, M.A.; Hahn,

M.S. “Inorganic-organic hybrid scaffolds for osteochondral regeneration,” J. Biomed. Mater. Res. Part A, 2010, 94, 112-121. PMID: 20128006.

2. Schoener, C.A.; Weyand, C.B.; Murthy, R.M.; Grunlan, M.A. “Shape memory polymers with silicon-containing segments,” J. Mater. Chem., 2010, 20, 1787-1793. PMCID: PMC3419533.

3. Zhang, D.; Giese, M.L.; Prukop, S.L.; Grunlan, M.A. “Polycaprolactone-based shape memory polymers with variable polydimethylsiloxane soft segments,” J. Polym. Sci., Part A: Polym. Chem., 2010, 49, 754-761. PMID: 22904597.

4. Zhang, D.; Burkes, W.L.; Schoener, C.A.; Grunlan, M.A. “Porous inorganic-organic shape memory polymers,” Polymer, 2012, 53, 2935-2941. PMID: 22956584.

5. Zhang, D.: Petersen, K.M.; Grunlan, M.A. “PDMS-PCL shape memory polymer (SMP) foams,” ACS Appl. Mater. & Interfaces, 2012, 5, 186-191. PMID: 23227875.

6. Munoz-Pinto, D.; Jimenez-Vergara, A.; Hou, Y.; Hayenga, H.N., Grunlan, M.A.; Hahn, M.S. “Osteogenic potential of poly(ethylene glycol)-poly(dimethylsiloxane) hybrid hydrogels,” Tissue Eng. Part A 2012,18, 1710-1719. PMID: 22519299.

7. Zhang, D.; George, O.J.; Petersen, K.M.; Jimenez-Vergara, A.C.; Hahn, M.S.; Grunlan, M.A. “A bioactive “self-fitting” shape memory polymer (SMP) scaffold with potential to treat cranio- maxillofacial (CMF) bone defects,” Acta Biomaterialia, 2014, 10, 4597-4605. PMID: 25063999.

Additional recent publication of importance to the field 8. Hou, Y.; Matthews, A.R.; Smitherman, A.M.; Bulick, A.S.; Hahn, M.S.; Hou, H.; Han, A.; Grunlan, M.A.

“Thermoresponsive nanocomposite hydrogels with cell-releasing behavior,” Biomaterials 2008, 29, 3175-3184. PMID: 18455788.

9. Hahn, M.S.; Liao, H; Munoz-Pinto, D.; Xin, Q.; Hou, Y.; Grunlan, M.A.; “Influence of hydrogel mechanical properties and mesh size on vocal fold fibroblast extracellular matrix production,” Acta Biomaterialia 2008, 4, 1161-1171. PMID: 18515199.

10. Hou, Y.; Schoener, C.A.; Regan, K.R.; Munoz-Pinto, D.; Hahn, M.S.; Grunlan, M.A. “Photo-crosslinked PEO-PDMSstar hydrogels: Synthesis, characterization, and potential application for tissue engineering scaffolds,” Biomacromolecules, 2010, 11, 648-656. PMID: 20146518.

11. Hou, Y.; Fei, R.; Burkes, J.C.; Lee, S.D., Munoz-Pinto, D.; Hahn, M.S.; Grunlan, M.A. “Thermoresponsive nanocomposite hydrogels: Transparency, rapid deswelling and cell release,” J. Biomat. Tissue Eng. 2011, 1, 93-100. PMID: 24377059.

12. Bailey, B.M.; Fei, R.; Munoz-Pinto, D.; Hahn, M.S.; Grunlan, M.A. “PDMSstar-PEG hydrogels prepared via solvent-induced phase separation (SIPS) and their potential utility as tissue engineering scaffolds,” Acta Biomaterialia, 2012, 8, 4324-4333. PMID: 22842033.

13. Fei, R.; George, J.T.; Means, A.K.; Grunlan, M.A. “Ultra-strong thermoresponsive hydrogels,” Soft Matter, 2013, 9, 2912-2919. PMID: PMC Journal – In Process.

14. Bailey, B.M.; Nail, L.N.; Grunlan, M.A. “Continuous gradient scaffolds for rapid screening of cell-material interactions and interfacial tissue regeneration,” Acta Biomaterialia, 2013, 9, 8254-8261. PMID:23707502.

15. Fei, R.; Hou, H.; Munoz-Pinto, D.; Han, A.; Hahn, M.S.; Grunlan, M.A. “Thermoresponsive double network micropillared hydrogels for cell release” Macromol. Biosci.; 2014, 14, 1346-1352. PMID: 24956117.

ARUM HAN Associate Professor, Department of Electrical and Computer Engineering

Associate Professor (joint appointment), Department of Biomedical Engineering Member of the Texas A&M Institute for Neuroscience

Graduate Faculty of Texas A&M Health Science Center Texas A&M University, College Station, TX 77843-3128

309C WERC, Tel (979) 845-9686, Fax (979) 845-6259, E-mail: [email protected] _______________________________________________________________________________________

EDUCATION Ph.D. Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, 2005. M.S. Electrical and Computer Engineering, University of Cincinnati, Cincinnati, OH, 2000. B.S. Electrical Engineering, Seoul National University, Seoul, Korea, 1997.

POSITIONS AND EMPLOYMENT 2011-present Associate Professor, Department of Biomedical Engineering, Texas A&M University, TX 2011-present Associate Professor, Department of Electrical and Computer Engineering, Texas A&M,

University, College Station, TX 2011-present Graduate Faculty, Texas A&M Health Science Center 2011-present Faculty, Texas A&M Institute for Neuroscience (TAMIN) 2009 Visiting Professor, Institute of Industrial Science (IIS), University of Tokyo (Jul. – Aug.) 2006 - 2011 Assistant Professor, Department of Biomedical Engineering, Texas A&M University, TX 2005 - 2011 Assistant Professor, Department of Electrical and Computer Engineering, Texas A&M,

University, College Station, TX 2000 - 2005 Research Assistant, School of Electrical and Computer Engineering, Georgia Institute of

Technology, Atlanta, GA 1998-2000 Research Assistant, Department of Electrical & Computer Engineering and Computer Science,

University of Cincinnati, Cincinnati, OH

RESEARCH INTEREST

Solving Grand Challenge Problems in the broad area of Energy and Health through the use of Micro/Nano Systems Technology and Multidisciplinary Team Approach

Microbes as Biorefinary for Bioenergy: Microbial fuel cells for electricity generation, microalgae for transportation fuel production Microbial Physiology and Functions in Infectious Disease: Understand microbial communications in microbial pathogenesis, understand host-pathogen interactions and evolutionary emergence of virulence, develop point-of-care (POC) diagnosis systems Microphysiological Systems (Organ-on-Chip): developmental neurobiology models of the central nervous system (CNS) Metastatic Cancer Analysis: Single-cell physical analysis of metastatic cancer cells

OTHER EXPERIENCES AND PROFESSIONAL MEMBERSHIP 2014- Executive Committee, Whole Systems Genomics Initiative (WSGI) 2011- Editorial Board Member, PLoS ONE 2014 Tutorial Co-Chair, IEEE 57th International Midwest Symposium on Circuits and Systems, College

Station, TX, USA

Arum Han, Texas A&M University

2012 Promotion Committee, The 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS), Okinawa, Japan

2011-2012 General Co-Chair, The 3rd Circuits and Systems for Medical and Environmental Applications (CASME 2012), 2012, Merida, Mexico

2010-2011 Technical Program Committee (TPC), The 16th International Conference on Solid-State Sensors, Actuators, and Microsystems (Transducers) 2011, Beijing, China

2010-present Member, American Chemical Society (ACS) 2009-present Member, American Society of Mechanical Engineers (ASME) 2007-present Member, Material Research Society (MRS) 2006-present Member, The Society for Neuroscience 1997-present Senior Member, Institute of Electrical & Electronics Engineers (IEEE)

HONORS AND AWARDS 2014 Engineering Genesis Award for Multidisciplinary Research, Texas A&M University 2014 Eugene Webb Faculty Fellow, Texas A&M University 2012 Texas A&M Engineering Experiment Station (TEES) Fellow 2012 Department of Electrical and Computer Engineering Outstanding Professor Award 2003 DARPA/NSF/Transducers Research Foundation Student Travel Award, Boston, MA 2002 IEEE EMBS Student Travel Grant, Wisconsin 2000 DARPA/NSF/Transducers Research Foundation Student Travel Award, Nara, Japan 1997-2000 University Graduate Scholarship, Department of Electrical and Computer Engineering and

Computer Science, University of Cincinnati, OH

JOURNAL REVIEWER (Regular Reviewer for 30 Journals as Listed Below) Advanced Materials Interface, Analyst, Analytical Chemistry, Analytica Chimica Acta, Annals of Biomedical Engineering, Biomedical Microdevices, Biomicrofluidics, Biosensors and Bioelectronics, Electrophoresis, IEEE Transactions on Biomedical Engineering, Integratie Biology, Journal of Biomechanics, Journal of Biomedical Materials Research Part A, Journal of Measurement Science and Technology, Journal of Microelectromechanical Systems, Journal of Micromechanics and Microengineering, Journal of Nanotechnology, Lab Chip, Langmuir, Medical Devices, Microfluidics and Nanofluidics, Molecular and Cellular Neuroscience, Nature Nanotechnology, PLoS ONE, RSC Advances, Scientific Reports, Sensors, Sensors and Actuators A, Sensors and Actuators B, Separation Science and Technology, Transactions on Automation of Electronic Systems

GRANT REVIEWER National Institutes of Health (NIH), Biotechnology Review Panel (ZRR1 BT-7 01), Review Panelist, 2012 National Institutes of Health (NIH), Biotechnology Review Panel (ZRR1 BT-B 02), Review Panelist, 2007 National Science Foundation (NSF), Division of Electrical, Communications and Cyber Systems (ECCS) CAREER Award Panelist, 2012 National Science Foundation (NSF), Sensors and Sensing Systems Program at Division of Civil, Mechanical, and Manufacturing Innovation (CMMI), Review Panelist, 2012 National Science Foundation (NSF), Communications, Circuits, and Sensing Systems (CCSS) Program at Division of Electrical, Communications and Cyber Systems (ECCS), Review Panelist, 2011, 2013 National Science Foundation (NSF), the Integrative, Hybrid & Complex Systems (IHCS) Program at Division of Electrical, Communications and Cyber Systems (ECCS), Review Panelist, 2010, 2011 Romanian National Council for Development and Innovation, 2011 Italian Ministry of Health, Proposal Reviewer, 2010


Bankhead-Coley Cancer Research Program, Florida Department of Health, 2010, 2012 The Innovation and Technology Commission, Hong Kong Special Administrative Region, Proposal Reviewer, 2008

CURRENT RESEARCH SUPPORT

IDBR: TYPE A – Microfluidic Fungal Transformation System for Ultra High-Throughput Functional Genomics National Science Foundation (NSF) DBI-1353759 (Han) 5/15/2014 – 4/30/2016 $302,791 Role: PI

Microfluidic Platforms for High-Throughput Screening of Microbes Utilizing Wastewater Qatar National Research Foundation (QNRF) NPRP 5-671-2-278 (Sadr) 10/15/2012 – 10/15/2015 $1,049,779 Role: PI This project is to develop a high throughput microbial electrolysis cell array for screening microbes and conditions that maximizes hydrogen production from wastewater.

EFRI-REM (Research Experience and Mentoring) Supplement National Science Foundation (NSF) EFRI 1431209 (Han) 8/15/2012 – 7/31/2016 $100,000 Role: PI

EFRI-PSBR: Microalgae Lab-on-Chip Photobioreactor Platform for Genetic Screening and Metabolic Analysis Leading to Scalable Biofuel Production National Science Foundation (NSF) EFRI 1240478 (Han) 8/15/2012 – 7/31/2016 $2,000,000 Role: PI This multi-disciplinary project is to develop microfluidic lab-on-chip devices with capabilities to precisely assay and manipulate parallel samples at single-cell resolution and utilize it to analyze and optimize the growth and hydrocarbon production potential of an engineered recombinant photosynthetic microalgae.

Multi-Frequency Multi-Parametric Acoustophoretic Microfluidic System for Particle and Cell Separation National Science Foundation (NSF) ECCS 1232251 (Kim) 8/1/2012 – 7/30/2015 $380,000 Role: Co-PI This project is to develop numerical models of acoustic standing wave based particle and cell separation system and validating them with microfluidic platforms.

Defeating Antibiotic Resistance Before It Emerges Bill and Melinda Gates Foundation OPP1058695 (de Figueiredo) 5/1/2012 – 10/31/2014 (no-cost extension) $100,000 Role: Co-PI This project is to develop a microfluidic lab-on-a-chip platform to accelerate research in antibiotic resistance.

FINISHED RESEARCH GRANT

Microfluidics based High Throughput Analysis of Polymicrobial Interactions


Defense Threat Reduction Agency (DTRA) HDTRA1-12-1-0028 (Han) 6/18/2012 – 6/17/2013 $74,819 Role: PI This project is to develop a microfluidic system capable of investigating microbe-to-microbe interactions at high throughput.

Hybrid Microbial-Electrochemical System for Waste Utilization Bill and Melinda Gates Foundation OPP1044645 (Han) 11/1/2011 – 4/30/2013 $100,000 Role: PI This project is funded to develop a hybrid microbial fuel cell (MFC) – microbial electrolysis cell (MEC) for hydrogen generation from waste.

Development of a Microfluidic High-Throughput Platform for Genetic Screening of Microalgae 2012 Whole Systems Genomics for Improved Human, Animal, and Environmental Wellbeing Catalyst Grant Internal (Han) 7/1/2012 – 8/31/2013 $10,000 Role: PI This project is to develop a high throughput microfluidic screening system for genetic variant screening.

Microsystem for Low-Concentration Oil Detection from Environment U.S. Army Corp of Engineers W9132T-12-2-0022 (Han) 5/1/2012 – 6/30/2013 $80,000 Role: PI This project is funded to develop a portable microsystem capable of detecting low-concentration oil from the environment.

Development of Biosample Pre-Processing Microfluidic Devices Korean Ministry of Knowledge Economy C11-00841 (Han) 7/1/2011 – 6/30/2013 $138,062 Role: PI This project is funded to develop a portable diagnosis system utilizing cell separation microsystems and nanowire-based antibody detection scheme.

Microbe-mediated Electricity Generation National Science Foundation (NSF) CBET-0854684 (de Figueiredo) 4/1/2009 – 3/31/2013 (no-cost extension) $300,000 Role: Co-PI This project is funded to develop a microfabricated microbial fuel cell array for high-throughput screening of bioelectrically active microbes.

Development of Prototype Pathogen Detection Lab-On-a-Chip (PADLOC) Systems for Real-time On-field Plant Disease Diagnostics United States Department of Agriculture (USDA) 2009-55605-05005 (Shim) 1/1/2009 – 12/31/2012 (no-cost extension) $999,988 Role: Co-PI This project is funded to develop a portable plant pathogen detection system based on microchip real-time PCR.

Micropatterned Thermoresponsive Nanocomposite Hydrogel Surfaces with Self-Cleaning Behavior National Science Foundation (NSF) CBET-0854462 (Grunlan) 9/1/2009 – 8/31/2012 $300,000


Role: Co-PI The major goals of this project are to develop a micropatterned thermoresponsive nanocomposite hydrogel surfaces and characterize its cell releasing behavior.

CNS Myelination Co-Culture Microsystem for Axon-Glia Signaling National Institutes of Health/National Institute of Mental Health (NIH/NIMH) R21MH085267 (Han) 1/1/2009 – 12/31/2011 $387,053 Role: PI The major goals of this project are to develop a neuron-glia co-culture microfluidic system to investigate the effect of localized axon-glia contacts on myelination of central nervous system.

An Integrated Microfluidic Cryo-Cooling System for MR Microcoils National Institutes of Health/National Institute of Biomedical Imaging and Bioengineering (NIH/NIBIB) R21EB07297-01 (Han) 6/1/2007-5/31/2011 $387,373 Role: PI The major goals of this project are to develop a microfluidic cryo-cooling channel integrated with MR surface coils for MR imaging.

Hybrid Nano/Micro/Bio Packaging for Nano/Micro Scale Bio-IT Elements Seoul Technopark and the Korean Ministry Knowledge Economy 1002970790 (Han) 6/1/2007-5/31/2009 $144,513 Role: PI This project is to develop microfluidic and lab-on-a-chip packing technologies.

Pigment Ink Flow Optimization through Analysis of Particle Laden Flow in Microchannel Samsung Electronics, Inc. C08-00680 (Han) 6/20/2008 – 5/19-2009 $120,000 Role: PI This project is to evaluate ink flowability inside microfluidic channels embedded in ink cartridges in inkjet printing systems.

Ink Flowability inside Microchannel of Ink Cartridge and Chip Samsung Electronics, Inc. C07-00535 (Han) 7/1/2007 – 6/30/2008 $99,800 Role: PI This project is to evaluate ink flowability inside microfluidic channels embedded in ink cartridges in inkjet printing systems.

Transmit/Receive Single Echo Acquisition MRI National Institutes of Health/National Institute of Biomedical Imaging and Bioengineering (NIH/NIBIB) 1R21EB005695 (Wright) 8/1/2006-7/31/2010 $403,695 Role: Co-PI This project is to develop a surface coil array for MRI application.

BOOK CHAPTERS 1. J. Park, S. Kim, J. Li, and A. Han, “Microfluidic Systems for Quantitative Axon Growth Analysis, a Chapter

of Microfluidic and Compartmentalized Platforms for Neurobiological Research, Springer, 2014, in press.


2. J. Park, S. Kim, J. Li, and A. Han, “Chapter 7: Axon Length Quantification Microfluidic Platform for Growthand Regeneration Study” in Axon Growth and Regeneration: Methods and Protocols (Editor: Andrew J.Murray), Springer, 2014.

3. G. Londe, A. Han, H. J. Cho, Functional Nanostructures: Chapter 3: MEMS for Nanotechnology-top-downPerspective, 2007.

JOURNAL PUBLICATIONS

1. H. Wang, J. Kim, A. Jayaraman, and A. Han, “Microfluidic Geometric Metering-based Multi-ReagentMixture Generator for Robust Environmental Toxin Screening,” Biomedical Microdevices, 2014,accepted.

2. C. Ban, J. Park, D. –Y. Jang, and A. Han, “Liquid-phase Capillary Etching of Poly(dimethylsiloxane)Microchannels with Tetra-n-butylammonium Fluoride,” J. Microelectromechanical Systems (JMEMS),Vol. 23 (2), pp. 276-283, 2014.

3. H. S. Kim, T. L. Weiss, T. P. Devarenne, and A. Han, “A MicrofluidicPhotobioreactor Array Demonstrating High-throughput Screening forMicroalgal Oil Production,” Lab on a Chip, Vol. 14 (8), pp. 1379-1482, 2014, published as front cover. (Impact Factor: 5.7; Selected as Lab on a Chip HOT Article)

4. H. Wang, Z. Liu, C. Koo, S. Kim, Y. Cho, D. –Y. Jang, Y. –J. Kim, and A. Han,“Microfluidic Acoustophoretic Force Based Low Concentration Oil Separationand Detection from Environment,” Lab on a Chip, Vol. 14, pp. 947-956, 2014.(Impact Factor: 5.7)

5. C. Koo, R. F. Godley, M. P. McDougall, S. M. Wright, and A. Han,“Microfluidically Cryo-Cooled Spiral Microcoils with Inductive Coupling for MRMicroscopy,” IEEE Transactions on Biomedical Engineering, Vol. 61 (1), pp.76-84, 2014.

6. J. Park, S. Kim, S. I. Park, Y. Choe, J. Li, and A. Han, “A Microchip for Quantitative Analysis of CNS AxonGrowth under Localized Biomolecular Treatments,” J. Neuroscience Methods, Vol. 21, pp. 166-174,2014. NIHMSID #536218

7. C. Koo, M. Malapi-Wight, H. Kim, O. S. Cifci, V. Vaughn, B. Ma, S. Kim, H. Abdel-Raziq, K. Ong, Y. –K. Jo,D. Gross, W. –B. Shim, and A. Han, “Development of a Lab-on-a-Chip Real-Time PCR System forPortable Plant Disease Diagnostics, PLoS ONE, Vol. 8 (12), e82704, 2013.

8. M. Kelley, C. Koo, H. McQuilken, B. Lawrence, S. Li, A. Han, and G. Huff, “Frequency ReconfigurablePatch Antenna Using Liquid Metal as a Switching Mechanism,” Electronics Letters, Vol. 49 (22), pp.1370-1371, 2013.

9. J. Park, J. Wu, M. Polymenis, and A. Han, “Microchemostat Array with Low Dilution Volume Fraction forPopulation Controlled Microbe Culture,” Lab on a Chip, Vol. 13, pp. 4217-4224, 2013. (Impact Factor:6.5)

10. Y. Park, C. Koo, H. –Y. Chen, A. Han, and D. H. Son, “Ratiometric Temperature Imaging UsingEnvironment-Insensitive Luminescence of Mn-Doped Core/Shell Nanocrystals,” Nanoscale, Vol. 5, pp.4944-4950, 2013. (Impact Factor: 5.91). NIHMS472942.

11. W. Longsine-Parker, H. Wang, C. Koo, J. Kim, B. J. Kim, A. Jayaraman, and A. Han, “Microfluidic Electro-Sonoporation: A Multi-Modal Cell Poration Methodology through Simultaneous Application of Electric Fieldand Ultrasonic Wave,” Lab on a Chip, Vol. 13, pp. 2144-2152, 2013. (Impact Factor: 6.5)

12. A. Han, H. Hou, L. Li, H. S. Kim, and P. de Figueiredo, “Microfabricated Devices in Microbial BioenergySciences,” Trends in Biotechnology, Vol. 31 (4), pp. 225-232, 2013. (Impact Factor: 9.15)

www.rsc.org/loc

Lab on a ChipMiniaturisation for chemistry, physics, biology, materials science and bioengineering

ISSN 1473-0197

PAPERTimothy P. Devarenne, Arum Han et al.A microfl uidic photobioreactor array demonstrating high-throughput screening for microalgal oil production

Volume 14 Number 8 21 April 2014 Pages 1379–1482


13. H. Hou, X. Chen, L. E. Garner, A. W. Thomas, A. Han, and G. C. Bazan, “Conjugated OligoelectrolytesIncrease Power Generation in E. coli Microbial Fuel Cells,” Advanced Materials, Vol. 25, pp. 1593-1597,2013. (Impact Factor: 13.88)

14. H. Hou, L. Li, C. U. Ceylan, A. Haynes, J. Cope, H. H. Wilkinson, C. Erbay, P. de Figueiredo, and A. Han,“A Microfluidic Microbial Fuel Cell Array that Supports Long-Term Multiplexed Analyses of Electricigens,”Lab on a Chip, Vol. 12, pp. 4151-4159, 2012. (Impact Factor: 6.5)

15. J. Park, H. Koito, J. Li, and A. Han, “Multi-Compartment Neuron-Glia Co-Culture Platform for Localized CNS Axon-Glia Interaction Study”, Lab on aChip, Vol. 12, pp. 3296-3304, 2012, published as back cover, NIHMS396117.(Impact Factor: 6.5)

16. J. Kim, D. Taylor, N. Agrawal, H. Kim, H. Wang, A. Han, K. Rege, and A.Jayaraman, “A Programmable Microfluidic Cell Array for Combinatorial DrugScreening,” Lab on a Chip, Vol. 12, pp. 1813-1822, 2012. (Impact Factor: 6.5)

17. W. Longsine-Parker and A. Han, “Laser Stenciling: A Low-Cost High-ResolutionCO2 Laser Micromachining Method”, J. Micromechanics andMicroengineering, Vol. 22, 015006, 2012 (Selected to be included in IOPSelect (http://Select.iop.org).

18. C. Koo, R. F. Godley, J. Park, M. P. McDougall, S. M. Wright, and A. Han, “AMagnetic (MR) Resonance Microscopy System using a Microfluidically Cryo-Cooled Planar Coil,” Lab ona Chip, Vol. 11 (13), pp. 2197-2203, 2011. NIHMSID #303840. (Impact Factor: 6.5)

19. K. I. McConnell, J. H. Slater, A. Han, J. L. West, and J. Suh, “Microcontact Printing for Co-Patterning ofCells and Viruses for Spatially Controlled Substrate-Mediated Gene Delivery,” Soft Matter, Vol. 7, pp.4993-5001, 2011.

20. H. Hou, L. Li, P. de Figueiredo, and A. Han, “Air-cathode microbial fuel cell array: A device for identifyingand characterizing electrochemically active microbes,” Biosensors and Bioelectronics, Vol. 26 (5), pp.2680-2684, 2011. (Impact Factor: 5.43)

21. B. J. Parmer, W. Longsine, E. P. Sabonghy, A. Han, E. Tasciotti, B. K. Weiner, M. Ferrari, and R. Righetti,“Characterization of Controlled Bone Defects using 2D and 3D Ultrasound Imaging Techniques,” Physicin Medicine and Biology, Vol. 55, pp. 4839-4859, 2010.

22. Y. H. Cho, J. Park, H. Park, X. Cheng, B. J. Kim, and A. Han, “Fabrication of High-Aspect-Ratio PolymerNanochannels using a Novel Si Nanoimprint Mold and Solvent Assisted Sealing,” Microfluidics andNanofluidics, Vol. 9, pp. 163-170, 2010. (Impact Factor: 4.20)

23. H. Hou, Y. Hou, M. A. Grunlan, D. J. Munoz-Pinto, M. S. Hahn, and A. Han, “Micropatterning of Poly(N-isopropylacrylamide) (PNIPAAm) Hydrogels: Effect on Thermosensitivity, Surface Properties, and Cell-Release Behavior,” Sensors and Materials, Vol. 22 (3), pp. 109-120, 2010. PMCID: 2784694.

24. J. Park, J. Li, and A. Han, “Micro-Macro Hybrid Soft-lithography Master (MMHSM) Fabrication for Lab-on-a-chip Applications,” Biomedical Microdevices, Vol. 12, pp. 345-351, 2010. PMCID: 2864814. (ImpactFactor: 3.37)

25. *H. C. Kim, *J. Park, Y. Cho, H. Park, A. Han, and X. Cheng, "Lateral-flow particle filtration and separationwith multilayer microfluidic channels," J. Vac. Sci. Technol. B, Vol. 27 (6), pp. 3115-3119, 2009.(Selected for publication in Virtual Journal of Biological Physics Research, Dec. 15, 2009) (*These authorscontributed equally as co-first authors)

26. J. Park, H. Koito, J. Li, and A. Han, “Microfluidic Compartmentalized Co-culture Platform for CNS AxonMyelination Research,” Biomedical Microdevices, Vol. 11, pp. 1145-1153, 2009. PMCID: 2783938.(Impact Factor: 3.37)

NAME Dr. Christian Hilty, Ph.D. POSITION TITLE

Assistant Professor of Chemistry eRA COMMONS USER NAME : chilty EDUCATION/TRAINING

INSTITUTION AND LOCATION DEGREE MM/YY FIELD OF STUDY Diploma 1999 Physics Dr. sc. 2004 Biophysics

Swiss Federal Institute of Technology, Zürich Swiss Federal Institute of Technology, Zürich University of California, Berkeley (postdoc) 2006 Chemistry

A. Personal StatementMy laboratory currently is pioneering the development of dynamic nuclear polarization, a hyperpolarizationtechnique, for real-time study of chemical and biochemical reactions by high-resolution NMR. We are applyingthe newly developed methods for the study of processes as diverse as enzyme catalyzed reactions, proteinfolding, and polymerization reactions. While a faculty member at Texas A&M University, where I have recentlybeen granted tenure, I have been managing several grants from federal and private institutions. These includea CAREER award from the National Science Foundation and a New Faculty Award from the Camille andHenry Dreyfus Foundation. They also include an award for an upgrade of a departmental NMR spectrometerwith a sensitive, state-of-the art cryoprobe. Previously, I have carried out postdoctoral work with Alex Pines atBerkeley (hyperpolarized magnetic resonance imaging coupled to microfluidics), and doctoral work with KurtWüthrich at ETH Zürich (NMR spectroscopy of membrane proteins). The ensemble of this work has resulted ina total of over 40 journal articles with over 900 citations.

B. Positions and HonorsProfessional Positions:1999-2004

2004-2006

2006-2012

Research Assistant, Swiss Federal Institute of Technology, ETH, Zürich, Switzerland Postdoctoral Researcher, Lawrence Berkeley National Laboratory, University of California, Berkeley, California Assistant Professor, Department of Chemistry, Texas A&M University, College Station, Texas

Honors: 2009 CAREER Award, National Science Foundation 2006 Camille and Henry Dreyfus New Faculty Award 2005 Raymond Andrew Prize, for an outstanding PhD thesis in magnetic resonance, European

Magnetic Resonance Conference (EUROMAR)

C. Selected Peer-reviewed Publications (5 selected from appointment at TAMU)Lee, Y., Zeng, H., Mazur, A., Wegstroth, M., Carlomagno, T., Reese, M., Lee, D., Becker, S., Griesinger, C.

and Hilty, C. Hyperpolarized Binding Pocket Nuclear Overhauser Effect for Determination of Competitive Ligand Binding. Angewandte Chemie International Edition 51(21): 5179-5182 (2012).

Hwang, S., and Hilty, C. Folding of a tryptophan zipper peptide investigated based on Nuclear Overhauser effect and thermal denaturation. Journal of Physical Chemistry B 115(51): 15355-15361 (2011).

Ragavan, M., Chen, H.-Y., Sekar, G. and Hilty, C. Solution NMR of Polypeptides Hyperpolarized by Dynamic Nuclear Polarization. Analytical Chemistry, 83(15): 6054-6059 (2011).

Zeng, H., Lee, Y. and Hilty, C. Quantitative rate determination by DNP enhanced NMR of a Diels-Alder reaction. Analytical Chemistry 82(21): 8897-8902 (2010).

Bowen, S., Hilty, C. Time-resolved dynamic nuclear polarization enhanced NMR Spectroscopy. Angewandte Chemie International Edition 47 (28): 5235-5237 (2008).

D. Research SupportACTIVELtr. Dated 4/3/12Hilty (joint PI): 9/1/2012-8/31/2014Texas A&M – Weizmann Collaborative Initiative, $100,000 (Hilty portion)Ultrafast Multidimensional NMR on Hyperpolarized Peptides and ProteinsThe goal of this project is to provide proof of principle for the use of DNP hyperpolarization in multidimensionalbiomolecular NMR, including the determination of protein structure and function, and drug discovery.

50813-ND7 Hilty (PI): 1/1/11-8/31/2013 The American Chemical Society Petroleum Research Fund, $100,000 Metallocene Catalyzed Polymerization Investigated by Hyperpolarized NMR The goal of this project is to apply hyperpolarization by dissolution dynamic nuclear polarization to the study of polymerization reactions. Role: PI

A-1658 Hilty (PI): 7/1/10-5/31/12

The Welch Foundation, $150,000 Molecular basis for autotransporter function The goal of this project is to identify structural features of molecular interactions that arise in the assembly of helical membrane proteins.

0846402 Hilty (PI): 02/01/09-01/31/14 National Science Foundation, $550,003 CAREER: Reaction mechanisms by real-time, hyperpolarization enhanced nuclear magnetic resonance This award was given for the development of methods to exploit hyperporarization for the study of enzyme catalysis and protein folding.

0840464 Russell (PI): 8/1/2009-7/31/2012 National Science Foundation, $247,238 CRIF:MU: Acquisition of a cryoprobe for a NMR spectrometer Role: Co-Investigator and Lead Writer (PI: Department Head per program requirement). This award was given to upgrade a departmental 500 MHz NMR spectrometer with a cryoprobe for enhanced sensitivity.

COMPLETED 7-21-06: Hilty (PI): 9/1/2006-8/31/2011Camille and Henry Dreyfus Foundation, $50,000 Structure and function of membrane proteins by NMR using DNP hyperpolarizationThis award was given in support of a research program aiming to study membrane proteins by NMR, and todevelop novel methods of pre-polarization for determining interactions and dynamic processes.

A-1658 Hilty (PI): 7/1/2007-5/31/2010The Welch Foundation, $150,000 Structural perspectives on transmembrane Helix Assembly by NMRThe goal of this project was to identify structural features of molecular interactions that arise in the assembly ofhelical membrane proteins.

Fellowship for Prospective Researchers: 7/1/04-6/30/05 Swiss National Science Foundation, $52,402 Xenon Biosensors applied to Microcoil NMR and NMR at Ultralow Magnetic Fields This fellowship was awarded for postdoctoral training at UC Berkeley.

E. Contributions in Research Training and Mentoring (9/2006 – present)

Graduate Students

Undergraduate Students

Research Associates

Ph.D.’s Awarded

M.S.’sAwarded

Current group 6 0 0 N/A N/A

Total 9 5 0 3 3 (non-thesis,

from BIOT program)

F. Contributions in Classroom EducationCourses taught (9/2006 – present)

Course Name Course Number Number of Sections Number of Students General Chemistry for Engineering Students CHEM 107 1 307

Physical Chemistry Laboratory I CHEM 325 1 16

Physical Chemistry Laboratory II CHEM 326 3 38

Physical Chemistry I CHEM 327 4 198 Analytical Chemistry I CHEM 601 5x(1/4 team taught) 91 Physical Methods in Biological Chemistry CHEM 689 3x(1/3,1/3,0.45 team

taught) 26

Classroom innovations - Constructed low-field NMR spectrometer and developed laboratory experiment for CHEM-325

(resulting in publication in J. Chem. Ed.) - Developed quantum-first approach and lecture hall demonstration experiments for CHEM-327.- Developed an enzyme kinetics laboratory experiment for middle/high school, which has been used

twice in TAMU Youth Adventure Program, and will be distributed next semester with Chemistry

MarkT.HoltzappleName Mark T. Holtzapple

Education University of Pennsylvania, Ph.D., Chemical Engineering, 1981 Cornell, B.S., Chemical Engineering, 1978

Academic Experience

Texas A&M University, Chemical Engineering, Professor, 1998–Present; Assoc. Prof, 1991–1998; Assist. Prof, 1986–1991.

Tufts University, Chemical Engineering, Lecturer, 1983–1985 Non-academic experience

US Army, Lieutenant and Captain, 1981–1985 StarRotor Corporation, president and vice president, 2001–present

Certifications & prof registration

none

Current Member-ship in prof organizations

American Institute of Chemical Engineers, American Chemical Society, American Society for Engineering Education, International Horn Society, Sigma Xi, Tau Beta Pi, Omega Chi Epsilon

Honors and Awards Odebrecht Award for Sustainable Development, 2014 William Keeler Memorial Award for Contribution, 2014 Bush Excellence Award for Faculty in Public Service, 2013 Commercialization Rising Star Award, Research Valley Partnership, 2008 Excellence in Innovation Award, Texas A&M University, 2007 Walston Chubb Award for Innovation, Sigma Xi, 2006 Texas A&M University Distinguished Lecture, 2006 Texas A&M Ingenuity Award, 2003 McGraw-Hill Environmental Champion Award, 1997 President's Green Chemistry Challenge Award, 1996


M. Holtzapple, S. Lonkar C. Granda, Producing Biofuels via the CarboxylatePlatform, Chemical Engineering Progress, 52–57 (March 2015).

B. Dale, M. Holtzapple, The Need for Biofuels, Chemical Engineering Progress,36–40 (March 2015).

JL Cope, AJM Hammett, EA Kolomiets, AK Forrest, KW Golub, EB Hollister, TJ DeWitt, TJ Gentry, MT Holtzapple, HH Wilkinson, Evaluating the performance of carboxylate platform fermentations across diverse inocula originating as sediments from extreme environments, Bioresource Technology, 155: 388–394 (2014).

ST Vasquez , J Dunkleman, SK Chaudhuri, A Bond, MT Holtzapple, Biomass conversion to hydrocarbon fuels using the MixAlco (TM) process at a pilot-plant scale, Biomass & Bioenergy, 62: 138–148 (2014).

KW Golub, AK Forrest, ME Wales, AJM Hammett, JL Cope, HH Wilkinson, MT Holtzapple, Comparison of three screening methods to select mixed-microbial inoculum for mixed-acid fermentations, Bioresource Technology, 130: 739–749 (2013).

F Ahmadi, AR Rad, MT Holtzapple, AJ Zamiri, Short-term oxidative lime pretreatment of palm pruning waste for use as animal feedstuff, Journal of the Science of Food and Agriculture, 93(8): 2071 (2013).

S Taco-Vasquez, MT Holtzapple, Conversion of isopropanol and mixed alcohols to hydrocarbons using HZSM-5 Catalyst in the MixAlco process, AICHE Journal, 59(7): 2549–2557 (2013).

S Taco-Vasquez, MT Holtzapple, Biomass Conversion to Hydrocarbon Fuels Using the MixAlcoTM Process, Oil & Gas Science and Technology – Revue

D IFP Energies Nouvelles, 68(5): 861–873 (2013). MP Landoll, MT Holtzapple, Kinetics study of thermal decomposition of calcium

carboxylate salts, Biomass & Bioenergy, 57: 205–214 (2013). AK Forrest, EB Hollister, TJ Gentry, HH Wilkinson, MT Holtzapple,

Comparison of mixed-acid fermentations inoculated with six different mixed cultures, Bioresource Technology, 118: 343–349 (2012).

KW Golub, SR Golub, DM Meysing, MT Holtzapple, Propagated fixed-bed mixed-acid fermentation: Effect of volatile solid loading rate and agitation at near-neutral pH, Bioresource Technology, 124:146–156 (2012).

M.P. Landoll, M.T. Holtzapple, Kinetics Study of Thermal Decomposition ofSodium Carboxylate Salts. Biomass and Bioenergy 45:195–202 (2012).

EB Hollister, AK Forrest, HH Wilkinson, DJ Ebbole, SG Tringe, SA Malfatti, MT Holtzapple, TJ Gentry, Mesophilic and Thermophilic Conditions Select for Unique but Highly Parallel Microbial Communities to Perform Carboxylate Platform Biomass Conversion, PLoS ONE,. 7(6): e39689 (2012).

L Zhu, CB Granda, MT Holtzapple, Prevention of calcium sulfate formation in seawater desalination by ion exchange, Desalination and Water Treatment, 36 (1–3): 57–64 (2011).

Service Activities Helped prepare departmental videos Chair Tenure and Promotion Committee Undergraduate Chair Graduate Chair

Professional Development Activities in the Last Five Years

Holtzapple, M.T. (PI), Detonation Shock and Countercurrent Digestion of Lignocellulosic Plant Wastes, Mars, Jul 2014 to Mar 2015, $250,000.

Holtzapple, M.T. (PI), Task 4 – Seawater Deoxygenation, Cameron, Mar 2013 to May 2013, $104,140.

Holtzapple, M.T. (PI), Task 3 – Seawater Deoxygenation, Cameron, Mar 2013 to May 2013, $225,475.

Holtzapple, M.T. (PI), Liquid Biofuels: Creating Economic Incentives for Improved Sanitation, Bill and Melinda Gates Foundation, Nov 2011 to Oct 2013, $100,000.

Holtzapple, M.T. (PI), Novel Mechanical Pretreatment for Lignocellulosic Feedstocks, DOE & Terrabon, Sep 2011 to Aug 2014, $2.8 million.

Program Director/Principal Investigator: ING, Nancy H.

BIOGRAPHICAL SKETCH

Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME

Ing, Nancy Hughes POSITION TITLE

Associate Professor of Animal Science and Veterinary Integrated Biosciences eRA COMMONS USER NAME (credential, e.g., agency login)

NANCYING EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)


University of Florida B.S. 1979 Zoology University of Florida D.V.M. 1984 Veterinary Medicine University of Florida Ph.D. 1988 Biochemistry Mol. Biology Baylor College of Medicine Post-doctoral 1992 Cell Biology

A. Personal Statement My research focuses on steroid hormone-regulated gene expression in mammalian reproductive tissues. My independent laboratory discovered the post-transcriptional mechanism by which estradiol up-regulates estrogen receptor expression to enhance estrogen responsiveness in the uterus: estradiol stabilizes estrogen receptor mRNA via specific sequence elements in the 3’untranslated region of the message. These studies are leading to investigations of microRNAs regulating gene expression via steroid hormones in responsive tissues. I am excited to extend my studies to glucocorticoid repression of testosterone synthesis in stallion testes, expected to have high relevance to man. I am dedicated to mentoring diverse students at undergraduate as well as graduate levels and my track record extends throughout my career. B. Positions and Honors. Positions and Employment 1986-1988 Research Assistant Department of Animal Science University of Missouri 1988-1992 Post-Doctoral Fellow Department of Cell Biology Baylor College of Medicine 1992- Assistant Professor Department of Animal Science Texas A&M University 1992- Joint Appointment Department of Veterinary Anatomy and Public Health (renamed Veterinary Integrative Biosciences) Texas A&M University 1998- Associate Professor Department of Animal Science Texas A&M University Other Experience and Professional Memberships 1986 Member, Publication and Membership Committees Society for the Study of Reproduction 1993 - Member, Exec. Comm., Faculty of Genetics Texas A&M University 1996- Member Endocrine Society 1999 - Member, Exec. Comm., Faculty of Reproductive Biology Texas A&M University 1997 - 2001 Editorial Board Biology of Reproduction 2000 - Member, Exec. Comm., Faculty of Biotechnology Texas A&M University 1998 - 2002 Editorial Board Domestic Animal Endocrinology 2007- Member Texas Faculty Association

2009 - Member Am. Society for Reproductive Medicine Honors 1979 Rita McTigue O'Connell Award Gainesville Women's Club 1979 Phi Beta Kappa 1980 ERF Award American Medical Association 1980 Graduate Fellowship for Women Entering Non-Traditional Careers University of Florida 1995 American Registry of Professional Animal Scientists 2000 Gamma Sigma Delta (Agricultural Honor Society) Texas A&M University 2005 Phi Zeta (Veterinary Medicine Honor Society) Texas A&M University 2012 Dean’s Outstanding Achievement Award for Faculty Mentoring Texas A&M University

C. Peer-reviewed publications (Selected from 45 peer-reviewed publications)

1. Ing, N. H., A. Laughlin, D. D. Varner, T. H. Welsh Jr., D. W. Forrest, T. L.Blanchard and L. Johnson

(2004) Gene expression in the spermatogenically inactive “dark” and the maturing “light” testis tissue of the prepubertal colt. J. Androl. 25:535-44. PMID:15223842

2. Ing, N.H., R.L. Wolfskill, S. Clark, J.A. deGrauuw, C.A. Gill (2006) Steroid hormones acutely regulate expression of a nudix protein-encoding gene in the endometrial epithelium of sheep Mol. Reprod. Devel. 73:967-76. http://www3.interscience.wiley.com/cgi-bin/fulltext/112613568/PDFSTART

3. Ing, N. H., D.A. Massuto, L.A. Jaeger (2008) Estradiol regulates A+U-rich RNA-binding factor 1 p45 binding to stabilizing regions within the 3' untranslated regions of estrogen receptor-α mRNA. J. Biol. Chem. 283:1764-72. PMID:18029355

4. Laughlin, A., T. H. Welsh Jr., C. C. Love, D. D. Varner, A. R. Parrish, D. W. Forrest, N. H. Ing (2009) In vitro culture of precision-cut testicular tissue as a novel tool for the study of responses to LH. In Vitro Cell Dev. Biol. – Animal 46:45-53. PMID:19915939

5. Ing, N. H. (2010) Estradiol up-regulates expression of the A + U-rich binding factor 1 gene in the sheep uterus. J. Steroid Biochem. Mol. Biol. 122: 172-179. PMID:20621185

6. Loux, S., K. R. Crawford, N. H. Ing, L. Gonsalez-Fernandez, B. Macias-Garcia, C. C. Love, D. D. Varner, I. C. Velez, Y.-H Choi, K. Hinrichs (2013) CatSper and the relationship of hyperactivated motility to calcium and pH kinetics. Biol Reprod 89:123

7. Ing, N. H., D. W. Forrest, C. C. Love, D. D. Varner (2014) Dense spermatozoa in stallion ejaculates contain lower concentrations of mRNAs encoding the sperm specific calcium channel 1, ornithine decarboxylase antizyme 3, aromatase and estrogen recptor alpha than less dense sperm. Theriogenology DOI: 10.1016/j.theriogenology.2014.04.016.

8. Ing, N.H., D. Abi-Ghanem, M.M.K Abbas, A. Kaushik, L. Berghman, J. B. Puschett (2014) Marinobufagenin regulates permeability and gene expression of human brain microvascular endothelial cells. J. Am. Phys. 306:R918-924.

9. Ing. N. H., D. W. Forrest, P. K. Riggs, S. Loux, C. C. Love, S. P. Brinsko, D. D. Varner, T. H. Welsh, Jr. (2014) Dexamethasone acutely down-regulates genes involved in steroidogenesis in stallion testes. J. Steroid Biochem. Mol. Biol. (in press).

10. Ing, N. H., S. P. Brinsko, K. O. Curley, D. W. Forrest, C. C. Love, K. Hinrichs, M. M Vogelsang, D. D. Varner, T. H. Welsh, Jr. (2014) Dexamethasone acutely regulates endocrine parameters in stallions and subsequently affects gene expression in testicular germ cells. Anim Reprod Sci (in press).

11. Faucette, A. N., V. A. Maher, M. A. Gutierrez, J. M. Jucker, D. C. Yates, T. H. Welsh, Jr., M. Amstalden, G. R. Newton, L. C. Nuti, D. W. Forrest, N. H. Ing (2014)Temporal changes in histomorphology and gene expression in goat testes during postnatal development. J. Anim. Sci. (in press)

BIOGRAPHICAL SKETCH

NAME

Ivanov, Ivan V. POSITION TITLE

Clinical Associate Professor of Bioinformatics eRA COMMONS USER NAME

IIVANOVEDUCATION/TRAINING


Sofia University, Bulgaria M.S. 1987 Mathematics

University of South Florida, Tampa, Florida Ph.D. 1999 Mathematics

Syracuse University, Syracuse, NY Post-doctoral 1999-2000 Mathematics Texas A&M University, College Station, TX Post-doctoral 2000-2003 Mathematics

Texas A&M University, College Station, TX Post-doctoral 2003-2005 Bioinformatics

A. Personal StatementMy training in mathematics, statistics, and bioinformatics provides me with the skill set needed to analyze complex high dimensional multimodal datasets. I have made contributions in several key areas of systems and computational biology: (i) system identification and inference from genome-wide data, (ii) complexity reduction and compression, and (iii) control of the dynamical behavior for the purposes of therapeutic intervention. My research is focused specifically on mathematical modeling of gene regulatory networks and more generally, on analyzing the responses of biological systems to various types of treatment and thus, given my background, expertise, and extensive experience, I am qualified to serve on this project.

B. Positions and Honors2005-2013 Clinical Assistant Professor of Bioinformatics, VTPP, Texas A&M University 2013- Clinical Associate Professor of Bioinformatics, Department of Veterinary Physiology and

Pharmacology, Texas A&M University 2014- Director, Quantitative Biology Core, Center for Translational and Environmental Health

Research, Texas A&M University 2012- Member of the Intercollegiate Faculty of the Professional Program of Biotechnology, Texas A&M 2009- Member of the Intercollegiate Faculty of Toxicology, Texas A&M University 2010- Application Researcher, IAMCS, Texas A&M University

C. Contributions to Science

Dr. Ivanov has made significant contributions to several areas of systems and computational biology: (i) Worked on system identification and inference from genome-wide data.(ii) Developed methods for complexity reduction and compression of computational models of genomic

regulation.(iii) Studied the problem of control of dynamical systems for the purposes of therapeutic intervention.(iv) Developed a novel Bayesian computational framework for the purposes of classification involving next

generation sequencing data.

This body of work has advanced the methodology of computational modeling for the purposes of prediction of multimodal high dimensional data and the respective biological processes. It is the interface between biology, mathematics, statistics, and engineering where one can expect to advance the understanding and scientific

modeling of complex biological systems. Dr. Ivanov’s contributions and close interactions with scientists from these fields can be traced in the select list of publications below.

Selected peer-reviewed publications (in chronological order) 1. J.M. Knight, L.A. Davidson, D. Herman, C.R. Martin, J.S. Goldsby, I.V. Ivanov, S.M. Donovan and R.S.

Chapkin. Non-invasive analysis of intestinal development in premature and full term infants using RNA-Sequencing, Scientific Reports Nature 4:5453; DOI:10.1038/srep05453 (2014). PMID:24965658

2. Ghaffari, N., Yousefi, M., Johnson, C.D., Ivanov, I., and Dougherty, E.R. Modeling the Next GenerationSequencing sample processing pipeline for the purposes of classification, BMC Bioinformatics, 2013, 14:307

3. M. Yousefi and I. Ivanov, Optimal Control of Gene Regulatory Networks with Uncertain Intervention Effects,IEEE GobalSIP 2013.

4. J. Knight, I. Ivanov, and E.R. Dougherty, Multivariate Poisson Model for RNA-Seq Classification, IEEEGNESIPS13, 2013.

5. Schwartz, S, Friedberg, I., Ivanov, I., Davidson, L.A., Goldsby,J.S., Dahl, D.B., Herman, D., Wang, M.,Donovan, S.M., and Chapkin, R.S., A Metagenomic Study of Diet-Dependent Interaction Between GutMicroflora and Host in Infants Reveals Differences in Developmental and Immune Responses, GenomeBiology, 13:R32 doi:10.1186/gb-2012-13-4-r32, 2012, PMID: 22546241.

6. Jia, Q., Ivanov, I., Zlatev, Z.Z., Alaniz, R.C., Weeks, B.R., Callaway, E., Goldsby, J, Davidson, L., Fan, Y.,Zhou, L., Lupton, J.R., McMurray, D.N., and Chapkin, R.S., Fish oil and curcumin combination modulatecolonic cytokinetics and gene expression in DSS-treated mice, British Journal of Nutrition,106:519-529, 2011,PMID: 21401974.

7. Kachroo P, Ivanov I, Davidson L, Chowdhary B, Lupton JR, Chapkin RS. Classification of diet-modulatedgene signatures at the colon cancer initiation and progression stages. Digestive Diseases and Sciences,2011; 56:2595-2604. PMCID: PMC3139012.

8. Zhao, C., Ivanov, I., Bittner, M., and Dougherty, E.R., Pathway regulatory analysis in the context of BayesianNetworks using the coefficient of determination, Journal of Biological Systems, 19(4):651-682, 2011.

9. Davidson, L., Wang, N., Shah, M., Lupton, J., Ivanov, I., and Chapkin, R., n-3 polyunsaturated fatty acidsmodulate carcinogen-directed non-coding microRNA signatures in rat colon, Carcinogenesis, 30(12):2077-84, 2009, PMCID: 2792315.

10. Ivanov, I., Complexity of the BN and the PBN Models of GRNs and Mappings for Complexity Reduction,invited chapter in the book Computational Methodologies in Gene Regulatory Networks, Sanjoy Das, DoinaCaragea, W. H. Hsu, Stephen M. Welch, Edts., IGI Global, 2009.

D. Current Research SupportU01CA162077 Lampe/Hullar/Chapkin (Multi-PIs) 9/1/11-8/31/16NIH/NCI Gut microbiota and colonic gene expression: A lignan trial in humansSubcontract with the Fred Hutchinson Cancer Center, Seattle, WA. We study how dietary lignans, metabolizedby gut bacteria, affect colon cell signaling pathways and impact colorectal cancer risk in humans.Role: Co-Investigator

RO1 CA168312 Chapkin (PI) 9/1/11-8/31/16 NIH/NCI Chemoprotective effects of natural products on colonic adult stem cells The focus of this proposal is to elucidate the effects of curcumin and a citrus bioactive, limonin, on colonic stem cell function and gene expression. Role: Co-Investigator

P30 ES023512-01 Walker (PI) 4/1/2014-3/31/2018 NIH/NIEHS Center for Translational Environmental Health Research The objectives are to: Build programmatic and scientific capacity for environmental health science research through member participation in Thematic Focus Areas; Enhance the capabilities of existing programs in environmental health sciences through Facility Core resources and the Pilot Project Program. The overall mission is to improve understanding of environmental influences on human health by integrating basic biomedical and engineering research. Role: Director of the Quantitative Biology Core

BIOGRAPHICAL SKETCH

NAME ARUL JAYARAMAN

POSITION TITLE Professor, Chemical Engineering, Biomedical Engineering, Microbial Pathogenesis and Immunology

eRA COMMONS USER NAME 1JAYARAMAN EDUCATION/TRAINING

INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY Birla Institute of Technology & Science, India

B.E 1992 Chemical Engineering Birla Institute of Technology & Science, India M.Sc 1992 Physics

Tufts University

M.S 1994 Biochemical Engineering University of California, Irvine

Ph.D 1998 Biochemical Engineering Massachusetts General Hospital Postdoc 2000 Biomedical Engineering

A. Personal StatementResearch in my laboratory focuses on inter-domain signaling between bacteria and human cells in complex,multi-signal environments, with the goal of identifying design principles underlying recognition of non-canonical signals. Specifically, we focus on signal recognition in different aspects of GI tract infections andinflammation. Work in my laboratory is highly inter-disciplinary in nature and involves development of novelmicroscale model systems for investigating bacterial chemotaxis and bacterial community and biofilmdevelopment, quantitative metabolomics for prediction and identification of bioactive microbiotametabolites, and elucidating the mechanisms of microbiota metabolites recognition in eukaryotic cells. Mylab has ongoing inter-disciplinary collaborations with Dr. Michael Manson that have led to identification ofmechanisms underlying sensing of non-canonical signals such as the autoinducer-2 (AI-2) andnorepinephrine by enteric bacteria, with Dr. Robert Alaniz on the discovery that the microbiota-derivedmetabolite indole modulates host cell inflammation, with Dr. Kyongbum Lee on predicting and validatingputative microbiota metabolites, with Dr. Robert Chapkin on the role of microbiota metabolites on stem cellbehavior, and with Dr. Stephen Safe on the recognition of metabolites by the arylhydrocarbon receptor.

B. Positions and Honors.Positions 1992-1993 Fermentation Engineer, Madurai Kamaraj University, India 1998-2000 Research Fellow in Surgery, Shriners Burns Hospital, Boston 2000-2003 Instructor in Surgery (Bioengineering), Harvard Medical School, Boston 2001-2003 Principal Investigator, Shriners Burns Hospital, Boston 2004-2010 Assistant Professor, Dept. of Chemical Engineering, Texas A&M University 2010 - 2013 Associate Professor, Dept. of Chemical Engineering, Texas A&M University 2013 - Professor, Dept. of Chemical Engineering, Texas A&M University

Awards and Honors 1994 Dean’s Fellowship, University of California, Irvine 1998 U.C. Regents Dissertation Fellowship, University of California, Irvine2009 NSF CAREER Awardee2009 Ray Nesbitt I Faculty Development Professorship2009 TEES Select Young Faculty Award2013 Ray Nesbitt I Professorship

Professional Memberships American Society of Microbiology American Chemical Society American Institute of Chemical Engineers

C. Selected peer-reviewed publications (out of 70 total)Relevant1. Jin, UH., Lee, SO., Sridharan, GV., Lee, K., Davidson, LA., Jayaraman, A., Chapkin, RD., Alaniz, RC.

And Safe, S. “Microbiome-derived tryptophan metabolites and their arylhydrocarbon receptor-dependentagonist and antagonist activities”. Molecular Pharmacology, 85: 777-88 (2014).

2. Hegde, M., Englert, D. L., Schrock, S., Cohn, W. B., Vogt, C., Wood, T. K., Manson, M. D. andJayaraman, A. “Chemotaxis to the quorum sensing signal AI-2 requires the Tsr chemoreceptor and theperiplasmic LsrB AI-2 binding protein”. Journal of Bacteriology. 193: 768-73 (2011).

3. Bansal, T., Alaniz, R., Wood, T. K. and Jayaraman, A. “The bacterial signal indole increasestransepithelial resistance and attenuates epithelial cell inflammation”. Proceedings of the NationalAcademy of Sciences. 107: 228-33 (2010). PMC2806735

4. Hong, S., Hegde, M., Kim, J., Jayaraman, A.# and Wood, T. K#. “Synthetic quorum sensing circuit tocontrol consortial biofilm formation and dispersal in a microfluidic device”. Nature Communications. 3:613 doin:10.1038/ncomms1616 (2012). #: Joint corresponding authors.

5. Englert, D. L*., Manson, M. D. and Jayaraman, A. “A Microfluidic (µFlow) method for quantifying bacterialchemotaxis”. Nature Protocols. 5: 864-72 (2010).

Representative 1. Kim, J., Hegde, M., Kim, S. H., Wood, T. K. and Jayaraman, A. “A Microfluidic device for high-throughput

bacterial biofilm studies”. Lab Chip. 12: 1157-63 (2012).2. Englert, D. L*, Adase, C, Jayaraman, A. and Manson, M. D. “Repellent Taxis to Nickel Ion Requires

Neither Ni2+ Transport nor the Periplasmic NikA Binding Protein”. Journal of Bacteriology. 192: 2633-7(2010). PMC2863559

3. Kim, J*., Hegde, M*. and Jayaraman, A. “Co-culture of bacteria and epithelial cells for investigatingsignal-mediated interactions in the GI tract”. Lab Chip 10: 43-50 (2010).

4. Englert, D. L*., Janakiraman, V., Jayaraman, A#. and Baskaran, H#. “Modeling growth and quorumsensing in biofilms grown in microfluidic chambers”. Annals of Biomedical Engineering. 37: 1206-16(2009). #: Joint corresponding authors

5. Hegde, M., Wood, T. K. and Jayaraman, A. “The neuroendocrine hormone norepinephrine increasesPseudomonas aeruginosa PA14 virulence through the las quorum sensing pathway”. AppliedMicrobiology and Biotechnology. 84: 763-6 (2009).

6. Lee, J., Zhang, XS., Hegde, M., Bentley, W. E., Jayaraman, A. and Wood, T. K. “Indole cell signalingoccurs primarily at low temperatures in Escherichia coli”. ISME Journal. 2: 1007-23 (2008).

7. Bansal, T., Jesudhasan, P., Pillai, S, Wood, T. K. and Jayaraman, A. “Temporal regulation ofenterohemorrhagic Escherichia coli virulence mediated by autoinducer-2”. Applied Microbiology &Biotechnology. 78: 811-9 (2008).

8. Bansal, T., Englert, D., Lee, J., Hegde, M., Wood, T. K. and Jayaraman, A. “Differential effects ofepinephrine, norepinephrine, and indole on Escherichia coli O157:H7 chemotaxis, colonization, and geneexpression”. Infection & Immunity. 75: 4597-607 (2007). PMC1951185

9. Lee, J., Jayaraman, A. and Wood, T. K. “Indole is an inter-species signal mediated by SdiA”. BMCMicrobiology 7: 42 (2007). PMC1899176

D. Research SupportNSF CBETRole: PI 8/1/13 – 7/31/16Title: Collaborative Research: Identification of Immunomodulatory Microbiota MetabolitesThe goal of this proposal is to quantify microbiota metabolites and assess their immunomodulatory activityin vitro.

NIH 1R21GM106251-01A1 Role: Co-PI 2/1/14 – 1/31/16 Title: Computational Metabolomics of Gut Microbiota Metabolites The goal of this proposal is to develop predictive models for identifying putative metabolic derivatives of dietary molecules that can be generated in the GI tract

BIOGRAPHICAL SKETCH

Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME Charles D. Johnson

POSITION TITLE Director, Genomics & Bioinformatics eRA COMMONS USER NAME (credential, e.g., agen-

cy login) EDUCATION/TRAINING

INSTITUTION AND LOCATION DEGREE YY FIELD OF STUDY Texas A&M University B.S. 1988 Agronomy Clemson University M.S. 1993 Plant Physiology Texas A&M University Ph.D. 2000 Plant Physiology Texas A&M University University of Louisville

Postdoc Postdoc

2003 2004

Computational Biology Bioinformatics

Employment and Appointments

Associate member Texas A&M University graduate faculty 2013- present Associate Director 8/2013-present

Center for Bioinformatics and Genomics System Engineering Texas A&M System, College Station, TX Director 6/2010-present

Genomics and Bioinformatics Texas A&M AgriLife, College Station, TX President 2007-2010

BioMath Solutions, LLC, Austin TX Senior Manager: Statistics / Bioinformatics 2006 – 2007

Asuragen, Inc. Austin, TX Manager of Expression Bioinformatics 2004 – 2006

Ambion, Inc. Austin TX Publications

1. Garcia MR, Amstalden M, Williams SW, Johnson CD, Nizielski SE, Keisler DH, and Williams GL. Leptin and pubertal development in heifers: relationship of ob gene expression to circulating leptin as measured by heterologous radioimmunoassay. 1999. Biol. Reprod. 60 (Suppl. 1): 253.

2. Johnson CD, Balagurunathan Y, Lu KP, Tadesse M, Falahatpisheh MH, Carroll RJ, Dougherty ER, Afshari CA, Ramos KS. Genomic profiles and predictive biological networks in oxidant-induced atherogenesis. Physiol Genomics. 2003 May 13;13(3):263-75. PMID: 12657712

3. Johnson CD, Balagurunathan Y, Tadesse MG, Falahatpisheh MH, Brun M, Walker MK, Dougherty ER, Ramos KS. Unraveling gene-gene interactions regulated by ligands of the aryl hydrocarbon receptor. Environ Health Perspect. 2004 Mar;112(4):403-12. PMID: 15033587

4. Partridge CR, Johnson CD, Ramos KS. In vitro models to evaluate acute and chronic injury to the heart and vascular systems. Toxicol In Vitro. 2005 Aug;19(5):631-44. Review. PMID: 15893448

5. Partridge CR, Williams ES, Barhoumi R, Tadesse MG, Johnson CD, Lu KP, Meininger GA, Wilson E, Ramos KS. Novel genomic targets in oxidant-induced vascular injury. J Mol Cell Cardiol. 2005 Jun;38(6):983-96. Epub 2005 Apr 19. PMID: 15910882

6. Thackaberry EA, Jiang Z, Johnson CD, Ramos KS, Walker MK. Toxicogenomic Profile of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in the Murine Fetal Heart: Modulation of Cell Cycle and Extracellular Matrix Genes. Toxicol Sci. 2005 PMID: 16120747

7. Charles R. Partridge, Charles D. Johnson, Kenneth S. Ramos In vitro models to evaluate acute

and chronic injury to the heart and vascular systems Toxicology in Vitro, Volume 19, Issue 5,

August 2005, Pages 631-644 8. Richard Shippy, Paul Wolber, Wendell D. Jones, Roderick V. Jensen, Stephanie Fulmer-Smentek,

Charles D. Johnson, P. Scott Pine, Cecilie Boysen, Xu Guo, Eugene Chudin, Yongming Andrew Sun, James C. Willey, Jean Thierry-Mieg, Danielle Thierry-Mieg, Robert A. Setterquist, Mike Wilson, Anne Bergstrom Lucas, Natalia Novoradovskaya, Adam Papallo, Yaron Turpaz, Shawn C. Baker, Janet A Warrington, Leming Shi, and Damir Herman. Using RNA sample titrations to assess microarray platform performance and normalization techniques. Nat Biotechnol. 2006 Sep;24(9):1123-31.

9. Leming Shi, Laura H. Reid, Richard Shippy, Shawn C. Baker, Patrick J. Collins, Francoise de Longueville, Ernest S. Kawasaki, Kathleen Y. Lee, Yuling Luo, Yongming Andrew Sun, Janet A. Warrington, James C. Willey, Robert A. Setterquist, Gavin M. Fischer, David J. Dix, Yvonne P. Dragan, Federico M. Goodsaid, Damir Herman, Roderick V. Jensen, Charles D. Johnson, Wendell D. Jones, Edward K. Lobenhofer, Raj K. Puri, Uwe Scherf, Jean Thierry-Mieg, Weida Tong, Charles Wang, Mike Wilson,, Lu Zhang,, William Slikker, Jr. The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol. 2006 Sep 8;24(9):1151-1161

10. Charles D Johnson ; Yoganand Balagurunathan ; Edward R. Dougherty ; Cynthia A Afshari ; Qiang He ; Kenneth S. Ramos. Insight into redox regulated gene networks in vascular cells 2007. Bioinformation 1(10)

11. Vasker Bhattacherjee, Partha Mukhopadhyay, Saurabh Singh, Charles Johnson, John T. Philipose, Courtney P. Warner, Robert M. Greene, M. Michele Pisano (2007) Neural crest and mesoderm lineage-dependent gene expression in orofacial development Differentiation 75 (5), 463–477.

12. Charles Johnson, Aurora Esquela-Kerscher, Giovanni Stefani, Mike Byrom, Kevin Kelnar, Dmitriy Ovcharenko, Mike Wilson, Xiaowei Wang, Jeffrey Shelton, Jaclyn Shingara, Lena Chin, David Brown and Frank J. Slack. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res. 2007 Aug 15;67 (16):7713-22 17699775

13. Dmitriy Ovcharenko, Kevin Kelnar, Charles Johnson, Nan Leng, and David Brown. 2007 Genome scale microRNA and siRNA screens identify small RNA modulators of TRAIL-induced death receptor apoptosis pathway. Cancer Research Cancer Research 67: 10782-10788

14. Leming et. al. (201 authors), The MAQC-II Project: A comprehensive study of common practices for the development and validation of microarray-based predictive models. 2010. Accepted for Publication, Nature Biotechnology.

15. Ying Wang, Noushin Ghaffari, Charles D Johnson, Ulisses M Braga-Neto, Hui Wang, Rui Chen, Huaijun Zhou Evaluation of the coverage and depth of transcriptome by RNA-Seq in chickens BMC Bioinformatics 2011, 12(Suppl 10):S5 (18 October 2011)

16. Ryan Doan, Noah D Cohen, Jason Sawyer, Noushin Ghaffari, Charlie D Johnson, Scott V Dindot. Whole-Genome Sequencing and Genetic Variant Analysis of a Quarter Horse Mare. BMC Genomics, 2012; 13 (1): 78

17. Clavijo et. al.(17 authors). Identification and analysis of the first 2009 pandemic H1N1 influenza virus from feral swine. Emerging Infectious Diseases Journal. Zoonoses and Public Health. DOI: 10.1111/zph.12006

18. A Nikooienejad, R Metz, BJ Yoon, CD Johnson; Fast DNA barcode generating algorithm using Radix Coding method. GENSiPS, 2012 ISBN: 978-1-4673-5234-5

19. E Atashpaz-Gargari, MS Esfahani, R Metz, CD Johnson; OBGene: Optimal barcode generator for NGS experiments.- GENSiPS, 2012 ISBN: 978-1-4673-5234-5

20. N Ghaffari, MR Youse, CD Johnson, I Ivanov, ER Dougherty Modeling the Next Generation Sequencing sample processing pipeline for the purposes of classification BMC bioinformatics 14 (1), 307 2013

21. Leming, Shi et al. (200 authors), FDA SEQC RNASEQ Quality Control Study, submitted Nature Biotechnology, 2013

http://onlinelibrary.wiley.com/doi/10.1111/zph.12006/abstract

Plant Science 22. Johnson, J.R., and Johnson C.D. 1992. Two Zesty Alternatives to Bell Pepper. American Vegetable

Grower. 5:24-27. 23. Johnson, J.R., and Johnson C.D. 1992. Nitrogen Fertility and Cultivar Influence Collard Yield and

Leaf Nitrogen Content. Clemson University Vegetable Report. 24. Johnson, J.R., and Johnson C.D. 1992. Habanero Pepper: World’s Hottest Pepper Comes to South

Carolina. Clemson University Vegetable Report . 25. Johnson, J.R., and Johnson C.D. 1993. Cash In On New Markets For Collards. American Vegetable

Grower. 1:34-26. 26. Johnson, C. D., and Decoteau D. R. 1996. Nitrogen and potassium fertility affects Jalapeno pepper

plant growth, pod yield, and pungency. HortScience 31:1119-1123. Book Chapter

1) Brun M., Johnson C.D., and Ramos K.S.. Clustering: revealing intrinsic dependencies in microarray data, Genomic Signal Processing: Perspectives, Genomic Signal Processing and Statistics, eds. E. R. Dougherty, I. Shmulevich, J. Chen, and Z. J. Wang, EURASIP Book Series on Signal Processing and Communication, Hindawi Publishing Corporation, 2005.

2) Davison, T. S., Johnson, C. D., and Andruss, B. F. (2006). Analyzing Micro-RNA Expression Using Microarrays. Methods Enzymol. 411, 14-34.

Patents (US and EU)

1. CD Johnson, MW Byrom, AG Bader, FJ Slack, D Brown, D Ovcharenko, K Kelnar FUNCTIONS AND TARGETS OF LET-7 MICRO RNAS. 2012 US Patent 20,120,282,696

2. Bader, A.G.; Byrom, M.; Johnson, C.D.; Brown, D.; MIR-200 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION 2009 EP Patent 2,076,599


4. Byrom, M.; Johnson, C.D.; Brown, D.; Bader, A.G.; MIRNA REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION 2009 EP Patent 2,102,341

5. Byrom, M.; Patrawala, L.; Johnson, C.D.; Brown, D.; Bader, A.G.; miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION 2009 EP Patent 2,102,342




9. Johnson, C.D.; Byrom, M.; Bader, A.G.; Slack, F.J.; Brown, D.; Ovcharenko, D.; Kelnar, K.; FUNCTIONS AND TARGETS OF LET-7 MICRO RNAS 2009 EP Patent 2,104,737

10. Bader, A.G.; Byrom, M.; Johnson, C.D.; Brown, D.; Patrawala, L.; MIR-15, MIR-26, MIR-31, MIR-145, MIR-147, MIR-188, MIR-215, MIR-216 MIR-331, MMU-MIR-292-3P REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION 2010 EP Patent 2,145,001

11. Bader, A.G.; Patrawala, L.; Byrom, M.; Johnson, C.D.; Brown, D.; MIR-34 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION 2010 EP Patent 2,167,138

12. Ovcharenko, D.; Johnson, C.D.; Bader, A.G.; Brown, D.; miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention 2008 US Patents 20090192114

13. Bader, A.G.; Byrom, M.; Johnson, C.D.; Brown, D.; mir-21 Regulated genes and pathways as targets for therapeutic intervention 2008 US Patents 20090192102

14. Bader, A.G.; Patrawala, L.; Wiggins, J.F.; Byrom, M.W.; Johnson, C.D.; Brown, D.; miR-34 Regulated Genes and Pathways as Targets for Therapeutic Intervention 2008 US Patents 20090227533

15. Byrom, M.W.; Patrawala, L.; Johnson, C.D.; Brown, D.; Bader, A.G.; miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION 2007 US Patents 20090175827

16. Bader, A.G.; Byrom, M.; Johnson, C.D.; Brown, D.; miR-20 Regulated Genes and Pathways as Targets for Therapeutic Intervention 2008 US Patents 20090163434

17. Bader, A.G.; Byrom, M.W.; Patrawala, L.; Johnson, C.D.; Brown, D.; miR-15, miR-26, miR-31, miR-145, miR-147, miR-188, miR-215, miR-216, miR-331, mmu-miR-292-3P REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION 2008 US Patents 20090131356

18. Bader, A.G.; Byrom, M.W.; Johnson, C.D.; Brown, D.; miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION 2008 US Patents 20090232893

19. Bader, A.G.; Byrom, M.W.; Patrawala, L.; Johnson, C.D.; Brown, D.; miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION 2008 US Patents

20. Bader, A.G.; Byrom, M.W.; Johnson, C.D.; Brown, D.; miR-200 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION 2008 US Patents

Scientific Software

1. mirInform: Led the development of miRInform® an automated data packaging and interactive exploration software tool that was launched as part of the DiscovArray product. Project manager, responsible for planning, design, implementation management, and marketing. Has been used over the last five years at Asuragen Inc. to process and deliver the majority of their service projects.

2. miRNA –QC Tool: Distributed by Affymetrix for three years as their primary signal process and analysis tool for their miRNA array product line.- http://goo.gl/Of7Ox Used throughout the miRNA field and part of hundreds of papers. The software was produced by BioMath Solutions LLC, under contract to Affymetrix.

3. FlexmiR – Data Analysis Software: Distributed by Luminex Inc. the software conducts signal process and basic statistical analysis and provides the user with basic plate QC information, both in figure and table form. The software has an intuitive and easy to use graphical user interface (GUI) and require no programming skills to operate. The software a key part of their miRNA product line. The software was produced by BioMath Solutions LLC, under contract to Luminex.

Microarray Design

1. Led bioinformatics team at Asuragen that developed the first custom Affymetrix miRNA array - DiscovArray®, Served as consultant to Affymetrix on their commercial miRNA array development and developed the analysis method and designed the analysis software used by Affymetrix (see miRNA-QC Tool)

Ambion TechNotes

1) Robert Setterquist, Mike Wilson, Charles Johnson, Shika Agarwal, Sharmili Moturi. Synthesize High Yields of Biotinylated aRNA. Ambion TechNote 12(3) page17-18

2) Penn Whitley, Sharmili Moturi, Jose Santiago, Charles Johnson, Robert Setterquist. Improved Microarray Sensitivity using Whole Blood RNA Samples. Ambion, Inc. TechNote 12(3) page 20-22

3) Charlie Johnson, Robert Setterquist, Sharmili Moturi, Charmaine San Jose, Penn Whitley. Increase Signal and Detect More Genes on Affymetrix® Arrays Ambion, Inc. TechNote 12(4) page 28-29

Synergistic Activities

As director of the Texas A&M AgriLife Genomics and Bioinformatics Service, I am responsible for promoting and facilitating genomics research across the Texas A&M system by providing individualized consulting services, access to instrumentation through a professional lab service group and bioinformatics analysis team. Worked with >500 of researchers over the last 3 years and assisted in the submission of over 250 genomics related grant applications.

http://goo.gl/Of7Ox

Curriculum Vitae

J. Spencer Johnston

Professor of Genetics/Entomology, Member of Genetics Faculty, Member of Graduate Faculty

Email: [email protected]

Phone: 979.845.8295

Undergraduate Education

University of Washington, Seattle, Washington, Zoology, B.S., 1967

Graduate Education

University of Texas, Austin, Texas, Drosophila genetics, 1972-‐1975, NIH Fellow

University of Arizona, Tucson, Arizona, Genetics, Ph.D., 1972 (Advisor: W. B. Heed)

Appointments

Sept. ‘97 – Present: Professor, Dept. Entomol., Texas A&M University, College Station, TX

1989 – Present: Dtr. Flow Cytometry, Center for Biosystematics and Biodiversity, TAMU

Sept. ‘86 – Aug. ’97: Assoc. Prof., Dept. Entomology, Texas A&M University, Col. Sta., TX

Jan. ‘80 – Aug. ’86: Assoc. Prof., Dept. Plant Science, Texas A&M University, Col. Sta., TX

Sept. ‘75 – Dec. ’79: Asst. Prof., Dept. Biology, Baylor University, Waco, TX

June ‘67 – July ’68: Systems Analyst, Boeing Company, Seattle, WA

Teaching Activities

My teaching involves undergraduate courses in forensic genetics (FIVS 308), population and ecological genetics (GENE 412 and 412H) and genetics seminar (GENE 481). The FIVS course covers the application of genetics in forensic science. GENE 412 covers the basic principles of population genetics, the impact of DNA sequence data on population studies, and presents population genetics through examples. GENE 481 involves student attendance at the regularly scheduled seminars of the TAMU faculty of genetics plus graded written summaries of selected seminars.

Research Interests:

Genomics: My laboratory is interested in the diversity of Arthropod genomes, and contributes to efforts to describe and annotate the complete genomic sequence of a wide variety of Arthropods, including the honey bee, mosquito, Antarctic midge, bedbug, body louse, varroa mite and others. A long term goal of my laboratory is to understand the forces that shape genomic diversity, between cells in an individual, between single individuals and between populations of a species, and among species.

Population level studies: We have been assessing the genetic impact of the arrival of the Africanized form of the honey bee, Apis mellifera scutellata. We have extensive collections of feral bees from colonies in South Texas and bait hive bees in Mexico spanning the period 1990 to 2003, which is three years prior, the time during, and the successive years after the invasion of the Africanized bee. We score mtDNA mitotypes and nuclear microsatellite loci and single nucleotide polymorphisms (SNPs). The data shows that the African and European mitochondrial lineages coexist, while the nuclear genome is a mixture of the genomes of both lineages. Using the same genetic approach, we are studying the population structure of the honey bee in Western Europe. This is an area of diversity, and endemism, that contains a significant portion of the genetic variation needed to enhance honey bee survival and productivity. We have studies on a wide variety of Arthropods, including, the walking stick, Drosophila species, a several species of beetles.

Genome size estimation: Our laboratory uses flow cytometry to provide genome size estimates for a variety of insects, plants and other animals. We measure genome size to correct questionable values produced by other methods, and provide new values for researches who need to know genome size to develop gene libraries. We uniquely determine genome size in groups of closely related organisms in an effort to better understand the process of genome size evolution.

Publications (Last 5 years)

Benoit, J. B. Z. N. Adelman, et al. (bedbug sequencing consortium). 2015. Unique features of a global human ectoparasite identified through sequencing of the bed bug genome. Nature Communications (in Press).

Chávez-‐Galarza, J., D. Henriques, J.S. Johnston, M. Carneiro, J. Rufino, J.C. Patton and M.A. Pinto. 2015. Revisiting the Iberian honey bee (Apis mellifera iberiensis) contact zone: maternal and genome-‐wide nuclear variations provide support for secondary contact from historical refugia. Mol. Ecol. 24: 2973–2992. DOI: 10.1111/mec.13223

Rangel, J., K. Strauss, K. Seedorf, CE Hjelmen, JS Johnston. 2015. Endopolyploidy changes with age-‐related polyethism in the honey bee, Apis mellifera." PLoS One 04/2015;10(4):e0122208. DOI:10.1371/journal.pone.0122208. 3.53 Impact Factor

Muñoz I., D. Henriques, J. Chávez-‐Galarza, J. Rufino, J. S. Johnston, M. A. Pinto. 2015. Reduced SNP panels for genetic identification and introgression analysis in the dark honey bee (Apis mellifera mellifera). PLoS One 10(4) e0124365. doi: 10.1371/journal.pone.0124365.

Cheng W., Lei J., Fox C., Johnston J.S., Zhu-‐Salzman K. 2015. Comparison of life history and genetic properties of cowpea bruchid strains and their response to hypoxia. J. Insect Phys. 75: 5-‐11. DOI information: 10.1016/j.jinsphys.2015.02.008

Arnqvist Goren, Ahmed Sayadi, Elina Immonen, Cosima Hotzy, Daniel Rankin, Midori Tuda, Carl E. Hjelmen, J. Spencer Johnston. 2015. Correlated evolution of genome size and reproductive fitness in seed beetles. Royal Society Series B (in Press).

Kapheim KM, H. Pan, et al. 2015. Genomic signatures of evolutionary transitions from solitary to group living. Science 348 (6239):1139-‐1143. DOI: 10.1126/science.aaa4788.

Ellis L.L., Huang W., Quinn A.M., Ahuja A., Alfrejd B., Johnston, J.S., Tarone A. 2014. Intrapopulation genome size variation in D. melanogaster reflects life history variation and plasticity. PLoS Genet. 10(7): e1004522. doi:10.1371/journal.pgen.1004522

Tarone, A.M., J.K. Tomberlin, J.R. Wallace, M.E. Benbow, R. Mohr, Edward B. Mondor, J.S. Johnston & S.L. VanLaerhoven. 2014. Reply: A Correspondence from a Maturing Discipline. Jn. Med. Ent. 51(3):490-‐492.

Soria-‐Carrasca, V., Z. Gompert, A. A. Comeault, T. E. Farkas, T. L. Parchman, J. S. Johnson, C. A. Buerkle, J. L. Feder, J. Bast, T. Schwander, S. P. Egan, B. J. Crespi, P. Nosil. 2014. Stick Insect genomes reveal natural selection’s role in parallel speciation. Science 334(6185):738-‐742.

Pinto, M.A., D. Henriques, J. Chavez-‐Galarza, P. Kryer, L. Garnery, R. Van Der Zee, B. Dahle, G. Soland-‐Recheweg, J.S. Johnston. 2014. Genetic integrity of the dark European honey bee (Apis mellifera mellifera) from protected populations: a genome-‐wide assessment using SNPs and mtDNA sequence data. Jn. Apic. Rch. 53(2):269-‐278. doi: 10.3896/IBRA.1.53.2.08

Pimsler, M. L., T. Pape, J. S. Johnston, R. A. Wharton, J. J. Parrott, D. Restuccia1, M. R. Sanford, J. K. Tomberlin, and A. M. Tarone. 2014. Structural and genetic investigation of the egg and first-‐instar larva of an egg-‐laying population of Blaesoxipha plinthopyga (Diptera: Sarcophagidae), a species of forensic importance. Jn. of Med. Ent. 51(6):1-‐13. DOI: http://dx.doi.org/10.1603/ME14029

Kelley, J.L., J.T. Peyton, A-‐S Fiston-‐Lavier, N.M. Teets, M.C. Yee, J.S. Johnston, C.D. Bustamante, R.E. Lee, Jr. & D.L. Denlinger. 2014. Compact genome of the Antarctic midge is likely an adaptation to an extreme environment. Nature Communications 5:4611.

Boussau, B., Z. Walton, J. A. Delgado, F. Collantes, L. Beani, I. J. Stewart, S. A. Cameron, J. B. Whitfield, J. S. Johnston, P. W. H. Holland, D. Bachtrog, J. Kathirithamby, J. P. Huelsenbeck. 2014. Strepsiptera, phylogenomics and the long branch attraction problem. PLoS ONE 9(10):e107709.

Portnoy, D. S., C. M. Hollenbeck, J. S. Johnston, H. M. Casman, J. R. Gold. 2014. Parthenogenesis in a reef whitetip shark Triaenodon obesus involves a reduction in ploidy. Jn. Fish Biol. doi: 10.1111/jfb.12415.

Huang, W., A. Massouras, et al. 2014. Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines . Genome Res. (Impact Factor: 14.4). 04/2014; doi:10.1101/gr.171546.113.

Scholes, D.R., A.V. Suarez, A.A. Smith J.S. Johnston, K. N. Paige. 2014. Tissue-‐specific patterns of endopolyploidy in the giant ant Dinoponera australis. J. Hymenoptera Research. 37: 113-‐126

Chávez-‐Galarza, J., Henriques, D., Johnston, J.S., Azevedo, J., Patton, J.C., Muñoz, I., De la Rúa, P., Pinto, M.A. 2013. Signatures of selection in the Iberian honey bee (Apis mellifera iberiensis) revealed by a genome scan analysis of single nucleotide polymorphisms. Mol. Ecol. 22(23):5890-‐907 DOI. 10.1111/mec.12537.

Johnston, J.S., Schoener, M., & McMahon, D.P. 2013. DNA underreplication in the majority of nuclei in the Drosophila melanogaster thorax: evidence from Suur and flow cytometry. Journal of Molecular Biology Research, 3(1), 47-‐54. 2.5

Picard, C.J., J.S. Johnston and A.M. Tarone. 2013. Increasing precision in development-‐based postmortem interval estimates: what’s sex got to do with it? Journal of Medical Entomology 50(2): 425-‐431.

Jacobson, A.L., J.S. Johnston, D. Rotenberg, A.E. Whitfield, W. Booth, E.L. Vargo and G.G. Kennedy. 2012. Genome size and ploidy of Thysanoptera. Insect Molecular Biology 1165:12-‐17. doi: 10.1111/j.1365-‐2583.2012.01165 3.0

Kathirithamby, J., G. K. Lechner, D.P. McMahon, A.L. Bryson, and J.S. Johnston. 2012. A free ride and lunch: Stylopization in the solitary hunting wasp, Ammophila fernaldi Murry and A. pictipennis (Walsh) (Hymenoptera: Sphecidae) by Paraxenos lugubris Pierce (Strepsiptera). Proc. Entomol. Soc. Wash. 114: 464-‐475.

Chávez-‐Galarza, J., Henriques, D., Johnston, J. S., Azevedo, J., Muñoz, I., De la Rúa, P., Patton, J. C., Costa, F., Pinto, M. A. 2012. Detection of loci under selection in Apis mellifera iberiensis as compared with two frequentist methods. In IV Jornadas Nacionais de Genética e Biotecnologia. Vila Real: UTAD. http://hdl.handle.net/10198/6792

Picard, C.J., J.S. Johnston and A.M. Tarone. 2012. Genome sizes of forensically relevant Diptera. Journal of Medical Entomology 49:192-‐197.

Hanrahan, S.J., Johnston, J.S. 2011. New genome size estimates of 134 species of arthropods. Chromosome Research 19:809-‐23.

Chávez-‐Galarza, J., J.S. Johnston, J. Azevedo, I. Muñoz, P. De la Rúa, J. C. Patton, and M.A. Pinto. 2011. Signatures of selection in the Iberian honey bee: a genome wide

KatyC.KaoName Katy C. Kao Education University of California, Los Angeles, 2005

University of California, Irvine, 1997 Academic Experience

Associate Professor - Department of Chemical Engineering, Texas A&M University (9/2014 - present)

Assistant Professor – Department of Chemical Engineering, Texas A&M University (8/2008 – 8/2014)

Non-academic experience

Chemical Analysis Engineer. (8/1997-8/1999) Western Digital Corporation, Lake Forest, CA.

Certifications & prof registration Current Member-ship in prof organizations

AIChE, American Chemical Society, American Society of Microbiology, Society of Industrial Microbiology and Biotechnology

Honors and Awards Fluor Distinguished Teaching Award - 2013 TEES Select Young Faculty - 2011 – 2012 National Science Foundation - Faculty Early Career Development (CAREER)

Award - 2011 National Inst. of Health-National Research Service Award (NRSA) - 2007 Presidential Undergraduate Research Award - 1996-1997


Winkler J, Garcia C, Olson M, Callaway E, Kao KC*. "Evolved Escherichia coli osmotolerant mutants frequently exhibit defective n-acetylglucosamine catabolism and point mutations in the cell-shape regulating protein MreB." Applied and Environmental Microbiology. 2014. Doi: 10.1128/AEM.00499-14.

Reyes LH, Gomez JM, Kao KC*. “Improving carotenoids production in yeast via adaptive laboratory evolution.” Metabolic Engineering. 2014. Jan:21: 26-33.

Highlighted in Evolutionary Applications March 2014. Volume 7, Issue 3: 337-338.

Reyes LH, Abdelaal AS, Kao KC*. "Genetic Determinants For N-Butanol Tolerance In Evolved E. Coli Mutants. Cross Adaptation And Antagonistic Pleiotropy Between N-Butanol And Other Stressors." Applied and Environmental Microbiology. 2013. Sept;79(17):5313-20.

Almario MP, Reyes LH, Kao KC*. "Evolutionary engineering of Saccharomyces cerevisiae for enhanced tolerance to hydrolysates of lignocellulosic biomass." Biotechnology and Bioengineering. 2013. doi: 10.1002/bit.24938.

Winkler J, Kao KC*. "Harnessing Recombination to Speed Adaptive Evolution in Escherichia coli." Metabolic Engineering. 2012. Sep;14(5):487-95.

Reyes LH, Almario MP, Winkler J, Orozco MM, Kao, KC*. "Visualizing evolution in real time to determine the molecular mechanisms of n-butanol tolerance in Escherichia coli." Metabolic Engineering. Metabolic Engineering. 2012. Sep;14(5):487-95.

Winkler J, Kao, KC*. "Computational identification of adaptive mutants using the VERT system." Jrnl of Biological Engineering. 2012. 6, 3.

Huang M, McClellan M, Berman J, Kao KC*. "Evolutionary dynamics of Candida albicans during in vitro evolution." Eukaryotic Cell. 2011. Sept 2. PMID: 21890821.

Reyes LH, Almario MP, Kao KC*. “Genomic Library Screens for Genes Involved in n-Butanol Tolerance in Escherichia coli.” PLoS ONE. 2011: March 8;6(3):e17678.

Kao KC, Sherlock G. “A Genome-Wide Analysis Reveals No Nuclear Dobzhansky-Muller Pairs of Speciation Genes Between S. cerevisiae and S. paradoxus, but Suggests More Complex Incompatibilities.” PLoS Genetics. 2010: Jul 29;6(7):e1001038.

Service Activities DEPARTMENTAL/COLLEGE SERVICE: • Undergraduate committee - 2008 - current• Graduate admissions committee - 2012 - 2013• Faculty mentor - 2009 - 2011• Departmental climate committee - 2010 - 2011• ABET course coordinator for CHEN 282/382 - 2011 - current• Special Biosafety committee - 2013 - 2014• Awards committee - 2012 – current• Women Faculty Network (WFN) – 2014 – current• Outstanding Mentoring Award review committee for WFN – 2014• Faculty advisor for OXE – Spring 2014 - present• WSGI executive committee – 2014 - present• OXE faculty advisor - Spring 2014 - present

EXTERNAL SERVICE: • Journal reviewer• Panel reviewer

o National Science Foundationo Carolina Biotechnology Centero NASAo ERASys

• Editorial board membershipo PLoS ONE (May 2010 – present)o Journal of Biological Engineering (January 2013 - present)

• Professional Society Program committeeso Society of Industrial Microbiology and Biotechnology

" Fermentation program committee - 2014 - 2016 • Program chair - 2015

• Session chairo AIChE National Meetingo Society of Industrial Microbiology Annual Meetingo ACS Spring Meetingo Biochemical and Molecular Engineering Conference XIX

OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015)

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FIVE PAGES.

NAME: Maria D. King eRA COMMONS USER NAME (credential, e.g., agency login): MARIAKING POSITION TITLE: Research Associate Professor, Director of Bio-Chem Air Quality EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)


Completion Date MM/YYYY

FIELD OF STUDY

Technical University, Budapest, Hungary B.A. 1979 Biology/Chemistry

Technical University of Budapest, Hungary B.S. 06/79 Biological & Chem. Eng.

Technical University of Budapest, Hungary M.S. 11/85 Biochemistry

Institute for Biotechnology, Berlin, Germany Ph.D. 06/86 Biotechnology /Chemistry

Rutgers University (New Brunswick, New Jersey) Postdoctoral 09/89 Microbiology

ICGEB, Trieste, Italy Postdoctoral 09/90 Biotechnology

Cornell University (Ithaca, New York) Postdoctoral 09/92 Molecular Biology

University of California, Davis Postdoctoral 09/94 Microbiology, Chemistry A. Personal Statement I am very excited to apply the wetted wall cyclone (WWC) bioaerosol collection technology for the detection and diagnosis of tuberculosis, one of the most infectious disease in the world. The WWC was developed in our Aerosol Technology Laboratory to sample bioaerosols at high air flows and concentrate the microbes over a million times in liquid. The cutpoint (where the collection efficiency is 50%) for the collector is 300 nm - 1 µm; it is currently the only device that can efficiently sample bioaerosols and aerosolized nanoparticles from large air volumes. The current R21 application offers a novel opportunity for the WWC to protect human health by integrating it with a Mycobacterium tuberculosis detector developed by our collaborator at the TAMU Health Science Center for the rapid diagnosis of the infectious lung disease tuberculosis. Our laboratory focuses on the optimization and application of the wetted wall cyclone system for the collection of aerosolized pathogens (viruses, bacteria, fungi) and their speciation and characterization by Illumina sequencing and real-time PCR (Polymerase Chain Reaction). We have been applying the collector system in a wide range of environmental projects, sampling air at different locations including mass transit systems, shower units, portable classrooms, corn fields, poultry facilities and analyzing the collected microbiomes by Illumina sequencing and real-time PCR. In our interdisciplinary projects we combine mechanical and electrical engineering with molecular biology and microbiology. B. Positions and Honors Positions and Employment 1983-1993 Senior Scientist, Biochemistry Dept, Central Food Research Institute, Budapest 1993-1996 Head of Biochemistry Dept, Central Food Research Institute, Budapest 1993-1994 Head of Lignocellulose Group, Int. Centre for Genetic Eng. & Biotechnology (ICGEB), Trieste 1996-2000 Research Associate, Biotechnology, Seminis Vegetable Seed Research Center, Woodland, CA 2000-2002 Senior Research Associate, Department of Plant Science, University of California, Davis

2002-2005 Senior Research Scientist, Biochemistry and Biophysics, Texas A&M University, TX 2005- Research Associate Professor, PI of Aerosol Technology Laboratory, Mechanical Engineering

Dept., and Lecturer, Professional Program in Biotechnology (MS), Texas A&M University, TX Selected Other Experience and Professional Memberships 1983 Member, Hungarian Biochemical Society 1986 Member, Hungarian Society of Microbiologists 1988 Secretary, Federation of European Chemists' Societies 1989 Member, American Society of Microbiology 2006 Member, American Association of Aerosol Research (AAAR) Honors 1994 "Vas Karoly" “Outstanding Scientist” Institute Award 1999 Selected Employee Bonus Award, Seminis Research Center, Woodland, CA 2005 Michele Costato Award, Best Conference Presentation, UpON Conference, Italy 2005 Science and Technology: Screening for screams; Bacteriology. The Economist. London, Apr.16, 2005. Vol.375. Iss.8422; pg.81 2012 Guest Editor, Biosensors 2014 “Professor of the Year 2013-2014” Texas A&M University Award C. Contributions to Science 1. Development of novel biosensing and bacterial diagnostic technologies: My initial research at the Department of Biochemistry and Biophysics at Texas A&M University led to the development of a prompt bacterium identification method based on fluctuation-enhanced sensing in fluid medium. The resulting patented SEPTIC nanowell technology, licensed by the company Telemedicine DxUpClose is in commercialization phase with the potential to be one of the first point-of-care diagnostics tools for bacterial identification at remote rural locations and in battlefields. It also forms the basis for our current odor-based bacterial identification technology that is under development in collaboration with faculty in Electrical and Chemical Engineering.

a. Kish, L.B., Chang, H-C., King, M.D., Kwan, Ch., et al. (2011). Fluctuation-Enhanced Sensing for Biological Agent Detection and Identification. IEEE Transactions on Nanotechnology, 10(6): 1238-1242.

b. Chang, H-C., Kish, L.B., King, M.D. & Kwan, Ch. (2009). Fluctuation-enhanced sensing of bacterium odors. Sensors and Actuators B (Chemical), 142, 429–434.

c. Kish, L.B., Schmera, G., King, M.D., Cheng, M., Young, R. and Granqvist, C.G. (2008). Fluctuation- Enhanced Chemical/Biological Sensing and Prompt Identification of Bacteria by Sensing of Phage Triggered Ion Cascade (SEPTIC), Internat. J. High Speed Electronics and Systems. 18: 11-18.

d. Dobozi-King, M., Seo, S., Kim, J.U., Young, R., Cheng, M. and Kish, L.B. (2005). Rapid nanoscale detection of bacteria: SEnsing of Phage-Triggered Ion Cascade (SEPTIC). J. Biol. Chem. Phys. 5: 3-7.

2. Development of the wetted wall cyclone collection technology: In our Aerosol Technology Laboratory we have developed effective wetted wall cyclone (WWC) units with air flow rates of 100, 300 and 1250 L/min. The autonomous WWC aerosol samplers utilize an air blast atomizer to create a liquid spray in the aerosol inlet. The sprayer creates droplets with a volume median diameter of about 40 µm, which are carried by the airflow through a rectangular cyclone inlet slot into the cyclone body where they impact on the inner wall. Air shear causes the impacted liquid to form a film that initially flows primarily in the angular direction where the majority of the liquid in the film interacts with the high velocity (~ 25 - 50 m/s) air jet, and is then transported along the cyclone wall to the region of the skimmer, where the entrapped liquid is then aspirated from the cyclone by an external pump. The WWC units operate efficiently at extreme temperatures (-22°C to 50°C), and in dry/wet air environments For the 100 L/min cyclone, the average collection efficiency for single cells and clusters of bacterial particles is 86% over a size range of 1 to 8.6 µm AD. Also, for the 100 L/min cyclone, typical output liquid flow rates are 100 µL/min, and the pressure loss is 1.6 kPa (6.4 inches H2O). Tests of the upgraded wetted wall cyclone (WWC-1250) with single cell and near-monodisperse clusters of bacterial spores showed an average aerosol-to-hydrosol collection efficiency of about 98% for the size range of 1.0 to 9.3 µm AD. The 100 L/min WWC unit, developed by the Aerosol Technology Laboratory (ATL) and the Applied Research Laboratory (ARL) at UT Austin, and fabricated by TSI Inc., (Shoreview, MN), (Fig. 2), has been used extensively in environmental

collections, demonstrating the potential for rapid collection and concentration of airborne particles at different environments.

a. King, M.D. and A.R. McFarland. (2012). Bioaerosol Sampling with a Wetted Wall Cyclone: Cell Culturability and DNA Integrity of Escherichia coli Bacteria. Aerosol Science and Technology, 46(1): 82–93.

b. King, M.D. and A.R. McFarland. (2012). Use of an Andersen Bioaerosol Sampler to Simultaneously Determine Culturable Particle and Culturable Organism Size Distributions. Aerosol Science and Technology, 46: 852–861.

c. McFarland, A.R., Haglund, J.S., King, M.D., Hu, S., Phull, M.S., Moncla, B.W. and Seo, Y. (2010). Wetted Wall Cyclones for Bioaerosol Sampling. Aerosol Science and Technology, 44(4), 241-252.

d. King, M.D., Thien, B.F., Tiirikainen, J.S. and McFarland, A.R. (2009). Collection characteristics of a batch-type wetted wall bioaerosol sampling cyclone. Aerobiologia, 25(4), 239-247.

3. Environmental bioaerosol – nanoaerosol collection and analysis: My current research in an interdisciplinary research team is uniquely positioned to address the needs for improved monitoring of public health emergencies by focusing on the collection, detection and speciation of potentially hazardous bioaerosols and aerosolized nanoparticles. We use the autonomous wetted wall cyclone (WWC) collector systems developed at our Aerosol Technology Laboratory to sample and concentrate aerosols in room-size air volumes. The bioaerosol (fungi, bacteria, viruses and toxins) and nanoparticle samples have been collected from industrial areas, residential buildings, classrooms, agricultural fields, and hospital and transportation centers. Indeed, in collaboration with faculty at TAMU and at UT Austin, we have been collecting aerosol, water and soil samples from urban environments using the WWC and a Hexacopter collector and develop a three dimensional TamuMAP. Within an NSF-funded project in collaboration with UT Austin we are currently studying bioaerosol exposure during shower events in residential and hospital environments and modeling the liquid flow pattern using particle image velocimetry to study and prevent biofilm formation in shower heads and stalls and minimize potential human health risks. This collaboration has also resulted in the development of our WWC system for the detection of tuberculosis in a joint preclinical study with TAMHSC. Another collaborative project with the faculty at UT Austin funded by the Sloan Foundation focuses on HVAC-related air quality measurements in portable classrooms. We have also extended our air sampling studies to meat processing facilities within a NAMI proposal with faculty at Animal Science. In this work the management of the data collection, the bio-chemical and molecular analysis in our laboratory, the statistical evaluation and the modeling of microbiomes are equally important and hence need a system-like approach.

a. Hoisington, A., Maestre, J.P., King, M.D., Siegel, J.A. & K.A. Kinney. (2014). Characterizing the Indoor Microbiome with Pyrosequencing: Impact of Sampler Selection. Building & Environment, 80: 1-9.

b. Meng, F., King, M.D, Hassan, Y.A., & Ugaz, V. M. (2014). Rapid Quantification of Airborne Environmental Nanoparticles in Room-sized Spaces. Environmental Science: Nano, 1: 358-366.

c. Kesavan, J., Schepers, D.R., Bottiger, J.R. King, M.D. and McFarland, A.R. (2013). Aerosolization of Bacterial Spores with Pressurized Medical Dose Inhalers. Aerosol Science and Technology, 47(10): 1108-1117.

d. Kassab., A., Ugaz, V.M., King, M.D. and Hassan, Y. A. (2012). High Resolution Study of Micro- meter Particle Detachment on Different Surfaces. Aerosol Science and Technology, 47(4): 351-360.

D. Research Support Ongoing Research Support Title: Collaborative Research: Characterization of the Microbiome Aerosolized in Shower Units PI (TAMU): Maria King Collaborator PI (UT): Kerry Kinney Type: NSF (NSF PD 12-1440 (1236040), Period: 09/01/12 - 08/31/16 The objectives of this project are to use metagenomics to delineate the microbiome collected with the wetted wall cyclone collector in residential shower units on three different water supplies. The study also includes the testing of biofilm formation related to droplet patterns using particle imaging velocimetry in an experimental shower unit in the PI’s laboratory. The proposed work is the first of its kind to interrogate the effect of municipal water source, season, shower operation and cleaning protocol on the bacterial and fungal microbiome released from showers.

Title: Particle Tracking Velocimetry Analysis of Electrostatic Spray Patterns PI: Maria King Type: Clorox Co. Period: 04/01/16 -08/31/16 The objectives of this contract are to develop an imaging technology for the measurement of the polydisperse particle size distribution of the droplet pattern generated by the electrostatic disinfectant sprayer and design and test an impactor to be collocated with the nozzle for the removal of small particles (< 10 µm) that could enter the human respiratory system and pose a health hazard. Title: Sampling in Portable Classrooms PI (TAMU): Maria King Collaborator PI (UT): Kerry Kinney Type: Sloan Foundation Period: 06/01/15-08/31/16 The objectives of this project are to determine the factors affecting the aerosolized microbiome in portable classrooms, by delineating the microbiomes of the air conditioning systems, crawl spaces, ceiling enclosures and the ambient environment and correlating them to temperature, humidity and chemical compounds/toxics (SOCs, VOCs).

Pushkar P. Lele

EDUCATION

Ph.D., Chemical Engineering 2010 University of Delaware, Newark DE Bachelor, Chemical Engineering 2005 Mumbai University Institute of Chemical Technology (UDCT), Mumbai, India PROFESSIONAL POSITIONS

Assistant Professor, Chemical Engineering, Texas A&M University, College Station TX, 2015 Postdoctoral Fellow, Molecular and Cellular Biology, Harvard University, Cambridge MA, 2010 Teaching Assistant, Chemical Engineering, University of Delaware, Newark DE 2007 Graduate Research Assistant, Chemical Engineering, University of Delaware, Newark DE 2005 PUBLICATIONS

1. K. M. Ford, R. Chawla, P. P. Lele, “Biophysical characterization of bacterial flagellar motors”, JOVE, invited article, under review.

2. P. P. Lele, T. Roland, A. Shrivastava, Y. Chen, H. C. Berg, “Directional dependence of stall torques in C. crescentus motors”, Nature Physics (2016), 12, 175-178.

3. P. P. Lele, A. Shrivastava, T. Roland, H. C. Berg, “Response thresholds in bacterial chemotaxis”, Science Advances (2015), 1:e150029ss.

4. P. P. Lele & H. C. Berg, “Switching of Bacterial Flagellar Motors Triggered by Mutant FliG”, Biophysical Journal (2015), 108 (5), 1275-1280.

5. A. Shrivastava, P. P. Lele, H. C. Berg, “Gliding is driven by a rotary motor”, Current Biology (2015), 25 (3), 338-341.

6. P. P. Lele, Basarab G. Hosu, H. C. Berg, “Dynamics of mechanosensing in the bacterial flagellar motor”, Proceedings of the National of Academy of Sciences, USA (2013), 110 (29), 11839-11844.

7. P. P. Lele, R. W. Branch, V. Nathan, H. C. Berg, “Mechanism for adaptive remodeling of the bacterial flagellar switch”, Proceedings of the National of Academy of Sciences, USA (2012), 109 (49), 20018-20022.

8. J. Wu, N. Shekhar, P. P. Lele, T. P. Lele, “FRAP analysis: accounting for bleaching during image capture”, PLoS ONE (2012), 7(8): e42854.

9. P. P. Lele, J. W. Swan, J. F. Brady, N. J. Wagner, E. M. Furst, “Colloidal diffusion and hydrodynamic screening near boundaries”, Soft Matter (2011), 7, 6844-6852.

10. P. P. Lele, E. M. Furst, “Assemble-and-Stretch method for creating two- and three-dimensional structures of anisotropic particles,” Langmuir (2009), 25, 8875-8878.

11. J. P. Singh, P. P. Lele, et al, “One and two dimensional assembly of colloidal ellipsoids in AC electric fields”, Physical Review E (2009), 79, 050401-050404.

12. P. P. Lele, M. Mittal, E. M. Furst, “Anomalous particle rotation and resulting microstructure of colloids in AC electric fields,” Langmuir (2008), 24(22), 12842-12848.

13. M. Mittal, P. P. Lele, E. W. Kaler, E. M. Furst, “Polarization and interactions of colloidal particles in AC electric fields”, Journal of Chemical Physics (2008), 129 (6), 064513-064519.

Artie McFerrin Department of Chemical Engineering, Texas A&M University College Station, TX 77843

Office room: Jack E. Brown 241 Email: [email protected]

Pushkar P. Lele

INVITED TALKS

1. ACS 72nd Annual Southwest Regional Meeting, Galveston, TX (2016) 2. Interface of Engineering and Life Sciences, Texas A&M University, College Station, TX (2016) 3. Squishy Physics, John A. Paulson School of Engineering and Applied Sciences, Harvard University,

Cambridge, MA (2015). 4. Department of Chemical Engineering, University of Virginia, Charlottesville, VA (2015) 5. Department of Chemical and Biological Engineering, Tufts University, Somerville, MA (2015) 6. Department of Chemical Engineering, University of Florida, Gainesville, Florida (2015) 7. Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Albany, NY

(2014). 8. MIT Parsons Microbial Systems seminar series, Cambridge, MA (2014). 9. Sensory Transduction in Microorganisms, Gordon Research Conference, Ventura, CA (2014). 10. Sensory Transduction in Microorganisms, Gordon Research Seminar, Ventura, CA (2014). 11. Indian Institute of Science (IISc), Bangalore, India (2011). SELECT PRESENTATIONS AND POSTERS

1. P. P. Lele, “Torque Anisotropy in bacterial flagellar motors”, Gordon Research Conference (Bacterial Cell Surfaces), Jun 26 - July 1, 2016, Mount Snow, VT.

2. P. P. Lele, H. C. Berg, “Long-time memory in bacterial chemotaxis”, Gordon Research Conference (STIM), Jan 17-22, 2016, Ventura, CA.

3. P. P. Lele, H. C. Berg, “Torque Generated in the Puller Mode Is Higher Than That in the Pusher Mode in Monoflagellated Bacteria”, AICHE National Conference, Nov 8-13, 2015, Salt Lake City, UT.

4. P. P. Lele, H. C. Berg, “Long-time memory in bacterial chemotaxis”, AICHE National Conference, Nov 15-19, 2014, Altlanta, GA.

5. P. P. Lele, A. Shrivastava, H. C. Berg, “Long-term memory in chemotaxis”, Boston Bacterial Meeting, June 12-13, 2014, Boston, MA.

6. P. P. Lele, H. C. Berg, “Dynamics of mechanosensing in the bacterial flagellar motor”, AICHE National Conference, Nov 3-6, 2013, San Francisco, CA

7. P. P. Lele, B. G. Hosu, H. C. Berg, “Dynamics of mechanosensing in the bacterial flagellar motor”, Boston Bacterial Meeting, June 14-15, 2013, Boston, MA.

8. P. P. Lele, R. W. Branch, V. Nathan, H. C. Berg, “Mechanism for adaptive remodeling of the bacterial flagellar switch”, Bacterial locomotion and Sensory Transduction XII Conference, Jan 20-25, 2013, Tucson, AZ.

9. P. P. Lele, R. W. Branch, H. C. Berg, “Turnover of FliM depends on conformation of FliG”, Gordon Research Conference (STIM), Jan 15-20, 2012, Ventura, CA.

10. P. P. Lele, V. Nathan, H. C. Berg, “Engineering a ligand-free molecular switch in the bacterial flagellar motor”, AICHE National Conference, Oct 19, 2011, Minneapolis, MN.

11. P. P. Lele and H. C. Berg, “Cooperative interactions in the bacterial flagellar switching complex”, Molecules, Movement, and Motors Symposium, Radcliffe Institute for Advanced Study, Oct 14, 2011, Cambridge MA

12. P. P. Lele, N J. Wagner, E. M. Furst, “Particle-wall hydrodynamic interactions in multi-particle ensembles”, Bacterial locomotion and Sensory Transduction XI Conference, Jan 16-21, 2011, New Orleans, LA.

13. P. P. Lele and E. M. Furst, “Particle-wall hydrodynamic coupling for multi-particle ensembles”, AICHE National Conference, Nov 16, 2009, Nashville, TN.

14. P. P. Lele and E. M. Furst, “Harnessing 2D assembly of isotropic particles for novel 3D anisotropic particle arrays”, ACS National Conference, Aug 18, 2009, Washington, DC.

Pushkar P. Lele

15. P. P. Lele and E. M. Furst, “Harnessing 2D assembly of isotropic particles for novel anisotropic particle arrays”, IACIS International Conference / ACS Colloid & Surface Sci. Symposium, June 18, 2009, New York, NY.

16. P. P. Lele and E. M. Furst, “Anomalous rotation and corresponding microstructures in AC electric fields”, 82nd ACS Colloid and Surface Science Symposium, June 15-18, 2008, Raleigh, NC.

17. P. P. Lele and E. M. Furst, “Order to Disorder transition due to anomalous rotation of particles in AC fields”, Directed Assembly of Functional Materials and Devices Workshop, March 19, 2008, NIST, Gaithersburg, Maryland.

18. P. P. Lele and E. M. Furst, “Order to disorder transition due to anomalous rotation of particles in AC fields”, 11th Tiger-Hen-Hawk Rheology Symposium, April 19, 2008, Newark DE.

19. P. P. Lele and E. M. Furst, “Anomalous rotation of a pair of spherical particles in AC electric fields”, 2008 APS Annual March Meeting, March 10-14, 2008, New Orleans, LA.

20. P. P. Lele and E. M. Furst, “Particle interactions driven by double layer polarization in AC electric fields”, 81st ACS Colloid Symposium, June 24-27, 2007, Newark, DE.

AWARDS

1. Best poster award, 20th Annual Boston Bacterial Meeting, Cambridge, MA (2014). 2. Semifinalist, Burroughs Wellcome Fund Careers at the Scientific Interface (2013). 3. Robert Macnab award for Outstanding poster presentation by a young investigator, Bacterial

locomotion and Signal transduction Conference, New Orleans, LA (2011). 4. Best poster award, 11th Tiger-Hen-Hawk (Princeton-Delaware-Lehigh) Rheology Symposium,

Newark, DE (2008). TEACHING EXPERIENCE

CHEN 382: Biprocess Engineering Fall, 2015 CHEN 689: Experimental and Computation Techniques in Cell Biology Spring, 2016 CHEN 382: Biprocess Engineering Fall, 2016 PROFESSIONAL ACTIVITIES

Texas A&M, Chemical Engineering Department Committees

• Graduate Student Committee Member

• Graduate Admissions and Recruitment Committee Member

• Student Research Week, Lunch Panel Memberships

• Board of Advisors, TEPTU, Inc (non-profit STEM Education Endeavor)

• American Institute of Chemical Engineers, Senior Member

• Biophysical Society

• American Society of Microbiology Journal Referee

• Proc. Natl. Acad. Sci; Trends Microbiol; E-Life; Scientific Reports; Biophysical Journal; PloS One

Lester, Richard H.

Richard H. Lester, Ph.D. Clinical Associate Professor

Executive Director Center for New Ventures and Entrepreneurship

Department of Management Mays School of Business Texas A&M University

Email: [email protected] Phone: 979-862-7091

EDUCATION

Ph.D., Texas A&M University, College Station Texas, 2003 Major: Strategic Management Minor: Sociology Dissertation title: A Road Less Traveled: Investigating the Outside Directors of

America’s Corporate Boards. Chair of Committee: Albert A. Cannella, Jr.

E.M.B.A., University of Houston, Houston Texas, 1999 Major: Business Management

B.S., Wright State University, Dayton Ohio, 1974 Major: Business Administration Minor: Operations and Production Management

TEACHING EXPERIENCE

Texas A&M University – 12-2006 to present Undergraduate and Graduate Strategic Management (Mgmt 466-Mgmt 680) Graduate Principles of Management (Mgmt 655) Graduate Foundations of New Ventures (Mgmt 637)

Center for Executive Development LEMIT Program EBV Engineering Certificate Summer Program

Louisiana Tech University – 2003 to 2006 Entrepreneurship and New Ventures Small Business Growth Principles of Management Strategic Management for the MBA

Texas A&M University (while Ph.D. Candidate) 2001-2003 Undergraduate Strategic Management (Mgmt 466) Undergraduate Entrepreneurship (Mgmt 461) Undergraduate Principles of Management (Mgmt 309)

Lester, Richard H.

PROFESSIONAL ACTIVITIES

Professional Experience

Triten Corporation Houston, Texaso Vice-President General Manager TAPCO International, 1996-1999o Vice-President Operations, 1992-1996.

Cooper Industries Houston, Texaso Plant Manager Cooper/Cameron Energy Services Group Missouri City, TX,

1989-1992o Manager Plant Operations, Materials Manager, Production Control Manager,

Inventory Control Manager Cooper Energy Services Ajax-Superior at Springfield,Ohio, 1981-1989.

Koehring Bomag Springfield, Ohioo Production Control Manager, Purchasing Agent, First Line Supervisor, Shop

Floor Coordinator, 1974-1981.

Professional Service

Center for New Ventures and Entrepreneurship and Texas Engineering ExtensionService (TEEX). Submitted a grant to develop entrepreneurial curriculum fordislocated workers due to the recession.

Center for New Ventures and Entrepreneurship- Texas A&M Universityo Named executive director November 2008

Editorial Board Membero Journal of Small Business Management

Ad Hoc reviewero Academy of Management Review

o Academy of Management Journal

o Academy of Management annual meetingo Journal of Business Studies

o Journal of Small Business Management

o Organization Science

o Strategic Entrepreneurship Journal

ABC 40, July 28, 2009The time is right for local entrepreneurs says Richard Lester in this segment, which airedon the 10 o’clock news:http://www.abc40.com/Global/category.asp?C=143385&nav=menu511_5

Austin American Statesman, Sunday August 09, 2009. Entrepreneurs in arecessionary era. Tim Eatonhttp://www.statesman.com/business/content/business/stories/other/2009/08/09/0809recessionbiz.html

http://www.abc40.com/Global/category.asp?C=143385&nav=menu511_5

http://www.statesman.com/business/content/business/stories/other/2009/08/09/0809recessionbiz.html

http://www.statesman.com/business/content/business/stories/other/2009/08/09/0809recessionbiz.html

Lester, Richard H.

Aggie Businesses Honored. Published Saturday, November 07, 2009 By VIMALPATEL. Bryan College Station Eagle. Quoted Richard H Lester on Aggie 100.http://www.theeagle.com/am/Aggie-businesses-honored

Academy of Managemento Session Chair- Diversification / M&A: Adding Stakeholder Sauce to the Mix

(16226). Atlanta Georgia 2006

Academic Committees

2007- 2010o Member department of management executive committee.

2005- 2006 (Louisiana Tech University)o Member- University wide Committee on Intellectual Property (nominated by

Dean of Business School)- Rich Kordall chair 2003 – 2006 (Louisiana Tech University)

o Member- Graduate Management council, Department of Managemento Member- Information Technology Committee-School of Businesso Member – CENIT, Center for Entrepreneurship and Information Technology

Other Academic Service

2012 Academic Committee Member for Doctor in Engineering for Daniel Cisneros from Biomedical Engineering

2011 Academic Committee Member for PhD in ERHD candidate Sarah Minnis. 2011 Academic Committee Member for Doctor in Engineering (D. Eng.) candidate

Adnan Ayub. 2011 Academic Committee Member for Masters Candidate Josh Fritz in Department

of Biotechnology, Anticipated graduation December 2012

2011 Academic Committee Member for Masters Candidate Ryan Huffman Department of Economics (Graduation summer 2011)

2011 Academic Committee Member for Masters Candidate Shen Ge Department of Aeronautical Engineering (Graduation summer 2011)

2011 Academic Committee Member for Masters Candidate Chad Workman Department of Land Development (Graduation spring 2011)

2011- MGMT 484- Internship Professoro Entrepreneurial Internship- Greg Glass/ Zach Coppinger/ Colin Marsh/ Doug

Sebastian/ Krishan Patel/ Matt Morton/ Matthew Morris/ Luis Salinas/ Emmy Richardson/ Stephen Haltom

2011-04 Faculty advisor for Myron Hawryluk. Project for Dr. Marcantonio BAUD 692 class in the EMBA program

2011 Society of Aggie Entrepreneurs (a TAMU student organization)o Faculty Advisor

2007-2011 Phi Beta Lambda- Texas A&M Univo Faculty Advisor-

2010- MGMT 685 Internship Professoro Entrepreneurial Internship - Marty Morrison

http://www.theeagle.com/am/Aggie-businesses-honored

Lester, Richard H.

2010- MGMT 484 Internship Professoro Entrepreneurial Internship-

2010-03 Faculty advisor for Tim Rebhorn. Project for Dr. Marcantonio BAUD 692class in the EMBA program.

2010-03. Faculty advisor for Dr. Marcantonio BAUD 692 class in the EMBAprogram.

2009-12. Faculty advisor for Seawinn Project in Dr. Marcantonio capstone class forthe MBA program.

2010-03. Finalized negotiation and development of a 20 year $410,000 scholarshipprogram for Mays Entrepreneurship students

2009 I2P competition- Austin Texas October- Won third place using Tech Transfertechnology surrounding concept developed by GigaFect aka Lone Star Molecular

2009- MGMT 484 Internship Professoro Entrepreneurial Internship- Dan Newbold/ LaShanta Green/ Alexandra

Delgado/ Austin Farmer 2009 Academic Committee Member for Masters candidate Alexander Leonard Ronge

(11-12). 2009 Academic Committee Member for Masters of Agriculture Candidate Jarrett

Irwin- Successful defense (11-10). Professional paper titled “Internship Experience atPleasant Hill Winery”.

2009 Academic Committee member for Masters of Engineering Candidate EkinErgul. Successful defense (2009-04-15).

2009 Academic Committee Member for Masters Candidate Binghuan Li- Successfuldefense (11-12)

2008 Academic Committee Member for Masters Candidate Alberto Aleman.Successful completion of oral exam (November).

2008 to Present EBV - Program Director- Entrepreneurship Bootcamp for Veteranswith Disabilities. Online program July–Aug. Residency Aug.

2008 Academic Committee Member for Masters Candidate Pierre Morel-Fatio. Planof study approved (09-08). Final presentation of thesis completed (12-10).

2008 Academic Committee member for Masters Candidate Andrew Gardner –Successful completion of oral exam (November).

2007 Academic Committee member for Masters in Construction Science CandidateUma Joshi – Successful defense (2007-11-07). Submitted to the Department ofConstruction Science, Texas A&M University. Professional paper titled: Analyzingvarious methods of risk reduction: A study for dealing with mold and mold relatedproblems adopted by the top 100 contractors building single family homes withinTexas.

2004-2006 Delta Sigma Pi (Louisiana Tech Univ)o Faculty Advisor- Student nominated, appointed by dean of the business

school. 2004-2006.

Organizations

Academy of Management 1999-2010

Lester, Richard H.

Self-development Activities

GCEC (National Consortium of Entrepreneurship Centers) Attended annualconference, Houston Texas. October 2009. Two presentations given, EBV, andCNVE initiatives.

TUNIE (Texas University Network for Innovation and Entrepreneurship). Attendedand presented CNVE initiatives at annual meeting in Houston Texas, October 2009and October 2010.

GCEC (National Consortium of Entrepreneurship Centers) Attended annualconference, Tucson Arizona. October 2008.

USASBE (United States Association of Small Business and Entrepreneurship).Annual conference January 10-13, 2008 San Antonio Texas. Represent Texas A&MUniversity as sponsor organization.

NCEC (National Consortium of Entrepreneurship Centers) Attended annualconference, Syracuse University, Syracuse. New York- October 4-7, 2007.

The Experiential Classroom VIII Level 2.0: The Future of EntrepreneurshipEducation, Syracuse University Sept 13-16, 2007.

NCEC (National Consortium of Entrepreneurship Centers) Attended annualconference in Cincinnati, Ohio- October 2006

Participant “The Experiential Classroom VI” at Syracuse University Sept 2005.Clinic theme “Reaching and Teaching Tomorrow’s Entrepreneurs”.

NCEC (National Consortium Entrepreneurship Centers) Attended annual conferencein Portland Oregon- October 2004

International Entrepreneurship Conference 2001 Atlanta, Georgia. May 2001.Participant at doctoral workshop on International Entrepreneurship. Sponsored byGeorgia Tech, Georgia State and University of Minnesota.

International Conference on the Mexican Auto Industry InAuto 2000, Mexico City,Mexico. May 2000. Presentation in conjunction with Dr. Kaye Husbands Fealing onfirst tier suppliers in the Canadian auto industry (report on survey results, MIT motorvehicular investment program MVIP).

HONORS AND RECOGNITIONS

(2012) Award for research published in the Journal of Managerial Studies (JMS) apaper titled Family and Lone Founder Ownership and Strategic Behavior' won theBest Paper Prize for JMS for 2011.

(2011) Received the Association of Former Students Distinguished Achievement

Award College Level for teaching. (2011) Selected to receive the 2011 Mays Teaching Grant (2009) Received the 2009 Best Unpublished Research Paper Award presented by the

Family Firm Institute Academic Awards Committee for a paper titled Stewardship or

Agency? A Social Embeddedness Reconciliation of Conduct and Performance in

Public Family Business, co-authored with Danny Miller and Isabelle Lebreton Miller. (2007) Received the 2007 Outstanding Doctoral Student Paper Award at the Southern

Management Association Conference in Nashville, Tn. in the Strategic Managementand Organizational Theory Track. First author Susie Cox a doctoral candidate atLouisiana Tech University (2007-11).

Lester, Richard H.

(2007) Recipient of the 2007 Jack. A. Dinos / Cox Family Enterprise Center BestFamily Business Paper at the Academy of Management meeting in Philadelphia, Pa.Paper co-authored with Danny Miller and Isabelle LeBreton-Miller titled DividedLoyalties: Governance, Conduct and Performance In Family and EntrepreneurBusinesses.

(2007) Recipient of the 2007 Family Firm Institutes’ Best Unpublished Paper awardin Miami Florida, for a paper co-authored with Danny Miller, Isabelle LeBretonMiller and Bert Cannella.

(2006) Summer research grant for 2003-2006 through the Center for Entrepreneurshipand Innovation Technology at Louisiana Tech University.

(2003) Fellowship grant from the Centers for New Venture and Entrepreneurship atTexas A&M University for the academic years 2001-2003.

(2003) Research grant through the Mays Business School for Summer 2003 for workon a Meta-analytic framework for top management teams in conjunction with TrevisCerto.

(2003) Awarded dissertation research grant award through the Mays Business School.

RESEARCH AND INTELLECTUAL CONTRIBUTIONS

I. Discipline-Based Scholarship

A. Peer Reviewed Journal Articles (most recent first)

Miller, D., LeBreton-Miller, I., Lester, R.H. 2011. Family Firm Governance,Strategic Conformity and Performance: Institutional versus Strategic Perspectives.Organization Science (orsc.1110.0728; published online before print April 3, 2012,

doi:10.1287/orsc.1110.0728).

Miller, D., Le Breton, I., Lester, R.H. 2011. Stewardship or Agency? A SocialEmbeddedness Reconciliation of Conduct and Performance in Public FamilyBusinesses. Organization Science, Vol. 22, No. 3: 704-721.

Miller, D., Le Breton, I., Lester, R.H. 2011. Family and Lone Founder Ownership andStrategic Behavior: Social Context, Identity, and Institutional Logics. Journal ofManagement Studies Vol. 48 (1): 1-25.

i. Family and Lone Founder Ownership and Strategic Behaviour' won the

Best Paper Prize for JMS for 2011.

Miller, D., Le Breton, I., Lester, R.H., 2010. Family Ownership and AcquisitionBehavior in Publicly-Traded Companies. Strategic Management Journal Vol. 31:201-233.

Collins, J.D., Holcomb, T.R., Certo, S. T., Hitt, M.A., Lester, R.H., 2009. Learningby doing: Cross-border mergers and acquisitions. Journal of Business Research, Vol.62, p. 1329-1334.

Lester, Richard H.

Lester, R.H., Hillman, A., Zardkoohi, A., Cannella, A.A. Jr., 2008. FormerGovernment Officials as Outside Directors: The Role of Human and Social Capital.Academy of Management Journal October Vol. 51(5), p. 999-1013.

Outlets quoting or using this research:o Agenda –Financial Times, 2009-01-20. Wagner, K. Why Presidential

Insiders Make Good Board Members.o Renaissance Radio- Interview Jan 19, 2009 conducted by Ron Morris

Pittsburgh- RR founder Ron Morris previews Tuesday’s Presidentialinauguration, and just what the transfer of power from George Bush toBarack Obama means for the business community. We’ll talk withRichard Lester, a Texas A & M Professor who co-authored a recent studythat determines just how much CEO’s can change from red to bluedepending on where the political power lies in our nation’s capital, andwhy it happens more than you may think. And we’ll get live analysisfrom Washington D.C., as well as local reaction to just what businessowners can expect.

o USA Today, 2009-01-15. Jones, D. Are businesses feeling more blue?

When Obama moves into the White House, will Republican-leaning

companies change their politics? Page 1B.o Business Week, 2008-12-22. Brynes, N. Out of Power Out of Luck. BTW

section. o BusinessWeek.com, 2008-12-15. Brynes, N. Out of Power Out of Luck.o USNEWS.com (U.S. News and World Report, Nov 28, 2008), Ewers, J.

Bush Cabinet Officials May Be Left Out in the Cold When They Enter the

Private Sector.o Washington Post, Federal Diary, Nov. 26, 2008, Davidson, J. Republicans

on Corporate Boards.o Reuter’s blogs, Front Row Washington, Tracking US Politics, Nov 24,

2008. Cowan, R. What's Next for Paulson, a Soup Line?

Yu, T., Lester, R.H., 2008. Moving Beyond Firm Boundaries: A Social NetworkPerspective on Reputation Spillover. Corporate Reputation Review. Spring, Vol. 11(1), p94-108.

Yu, T., Sengul, M., Lester, R.H., 2008. Misery Loves Company: The Spread ofNegative Impacts Resulting from an Organizational Crisis. Academy of ManagementReview. April, Vol. 33(2), p452-472.

Certo, S. T., Daily, C. M., Dalton, D. R. & Lester, R. H., 2008. Boards of directors’self interest: Expanding for pay in corporate acquisitions? Journal of Business Ethics,Jan, Vol. 77 Issue 2, p219-230.

Miller, D., Le Breton, I., Lester, R.H. Cannella, A.A. Jr., 2007. Are Family FirmsReally Superior Performers? Journal of Corporate Finance, Dec., Vol. 13 Issue 5, p.829-858.

BIOGRAPHICAL SKETCH

NAME Wenshe R. Liu


eRA COMMONS USER NAME (credential, e.g., agency login) WENSHELIU EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)


Beijing University, China B.S. 2000 Chemistry University of California, Davis, CA Ph.D. 2005 Biological Chemistry The Scripps Research Institute, La Jolla, CA Postdoc 2007 Chemical Biology

A. Personal StatementThe PI has more than seven years of experience in the development of the genetic noncanonical amino acid incorporation technique and has published close to twenty papers in this field. His group has independently developed a system that uses evolved pyrrolysyl-tRNA synthetase- Pyl

CUAtRNA pairs to genetically incorporate modified lysines into proteins in E. coli. The PI’s group is composed of both organic chemistry section and molecular biology section that guarantee the proposed work can be independently carried out in his group. Based on the PI’s credentials on the development of the genetic noncanonical amino acid incorporation technique and his recent success in leading his own independent research group, there is no doubt he is well suited for directing the proposed work. The PI has also formed a strong collaboration with Prof. Weston Porter in College of Veterinary Medicine of Texas A&M University. Prof. Porter’s group will provide necessary resources and expertise for the proposed p53-related work.

B. Positions and HonorsPositions

2000-2005 2005-2007

Graduate Researcher, Laboratory of Dr. M.D. Toney, University of California-Davis Postdoctoral Fellow, Laboratory of Dr. P.G. Schultz, The Scripps Research Institute

2007-2014 Assistant Professor of Chemistry, Texas A&M University 2014-present Associate Professor of Chemistry, Texas A&M University

Honors 1996-2000 G. Zen Fellowship1997-1998 Huikai Fellowship1998-1999 Canon Fellowship2000-2004 UC Systemwide Biotechnology Research Training Fellow2004 2012-2017

UC-Davis Summer Research AwardNSF Career Award

C. Selected Publications (with names as W. Liu and W.R. Liu)

1. Liu, C. C., Brustad, E., Liu, W., and Schultz, P. G. (2007) Crystal structure of a biosynthetic sulfo-hirudincomplexed to thrombin, Journal of the American Chemical Society 129:10648-10649.

2. Liu, W., Alfonta, L., Mack, A. V., and Schultz, P. G. (2007) Structural basis for the recognition of para-benzoyl-L-phenylalanine by evolved aminoacyl-tRNA synthetases, Angewandte Chemie 46:6073-6075.

3. Liu, W., Brock, A., Chen, S., Chen, S., and Schultz, P. G. (2007) Genetic incorporation of unnatural amino acidsinto proteins in mammalian cells, Nature methods 4:239-244.

4. Brustad, E., Bushey, M. L., Lee, J. W., Groff, D., Liu, W., and Schultz, P. G. (2008) A genetically encodedboronate-containing amino acid, Angewandte Chemie 47:8220-8223.

5. Graziano, J. J., Liu, W., Perera, R., Geierstanger, B. H., Lesley, S. A., and Schultz, P. G. (2008) Selecting foldedproteins from a library of secondary structural elements, Journal of the American Chemical Society 130:176-185.

6. Huang, Y., Russell, W. K., Wan, W., Pai, P. J., Russell, D. H., and Liu, W. (2010) A convenient method forgenetic incorporation of multiple noncanonical amino acids into one protein in Escherichia coli, MolecularbioSystems 6:683-686.

7. Huang, Y., Wan, W., Russell, W. K., Pai, P. J., Wang, Z., Russell, D. H., and Liu, W. (2010) Genetic

incorporation of an aliphatic keto-containing amino acid into proteins for their site-specific modifications, Bioorganic & medicinal chemistry letters 20:878-880.

8. Liu, W. R., Wang, Y. S., and Wan, W. (2011) Synthesis of proteins with defined posttranslational modificationsusing the genetic noncanonical amino acid incorporation approach, Molecular bioSystems 7:38-47.

9. Wang, Y. S., Russell, W. K., Wang, Z., Wan, W., Dodd, L. E., Pai, P. J., Russell, D. H., and Liu, W. R. (2011)The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of L-phenylalanine and itsderivatives, Molecular bioSystems 7:714-717.

10. Wang, Y. S., Fang, X., Wallace, A. L., Wu, B., and Liu, W. R. (2012) A rationally designed pyrrolysyl-tRNAsynthetase mutant with a broad substrate spectrum, Journal of the American Chemical Society 134:2950-2953.

11. Wang, Z. U., Wang, Y. S., Pai, P. J., Russell, W. K., Russell, D. H., and Liu, W. R. (2012) A facile method tosynthesize histones with posttranslational modification mimics, Biochemistry 51:5232-5234.

12. Wu, B., Wang, Z., Huang, Y., and Liu, W. R. (2012) Catalyst-free and site-specific one-pot dual-labeling of aprotein directed by two genetically incorporated noncanonical amino acids, Chembiochem : a European journalof chemical biology 13:1405-1408.

13. Hladilkova, J., Heyda, J., Rembert, K. B., Okur, H. I., Kurra, Y., Liu, W. R., Hilty, C., Cremer, P. S., andJungwirth, P. (2013) Effects of End Group Termination on Salting-Out Constants for Triglycine, The journal ofphysical chemistry letters 4:4069-4073.

14. Lee, Y. J., Wu, B., Raymond, J. E., Zeng, Y., Fang, X., Wooley, K. L., and Liu, W. R. (2013) A geneticallyencoded acrylamide functionality, ACS chemical biology 8:1664-1670.

15. Liu, W., Frank, S. J., Li, X., Li, Y., Zhu, R. X., and Mohan, R. (2013) PTV-based IMPT optimization incorporatingplanning risk volumes vs robust optimization, Medical physics 40:021709.

16. Lee, Y. J., Kurra, Y., Yang, Y., Torres-Kolbus, J., Deiters, A., and Liu, W. R. (2014) Genetically encodedunstrained olefins for live cell labeling with tetrazine dyes, Chemical communications 50:13085-13088.

17. Liu, W. R. (2014) Reports from the Chemical Biology of Texas Symposium at the 69th Southwest RegionalMeeting of the American Chemical Society, ACS chemical biology 9:319-322.

18. Ouyang, H., Fang, J., Shen, L., Dougherty, E. R., and Liu, W. (2014) Learning restricted Boolean network modelby time-series data, EURASIP journal on bioinformatics & systems biology 2014:10.

19. Tharp, J. M., Wang, Y. S., Lee, Y. J., Yang, Y., and Liu, W. R. (2014) Genetic incorporation of seven ortho-substituted phenylalanine derivatives, ACS chemical biology 9:884-890.

20. Tuley, A., Lee, Y. J., Wu, B., Wang, Z. U., and Liu, W. R. (2014) A genetically encoded aldehyde for rapidprotein labelling, Chemical communications 50:7424-7426.

21. Tuley, A., Wang, Y. S., Fang, X., Kurra, Y., Rezenom, Y. H., and Liu, W. R. (2014) The genetic incorporation ofthirteen novel non-canonical amino acids, Chemical communications 50:2673-2675.

22. Wan, W., Tharp, J. M., and Liu, W. R. (2014) Pyrrolysyl-tRNA synthetase: an ordinary enzyme but anoutstanding genetic code expansion tool, Biochimica et biophysica acta 1844:1059-1070.

23. Wang, X. A., Kurra, Y., Huang, Y., Lee, Y. J., and Liu, W. R. (2014) E1-catalyzed ubiquitin C-terminal amidationfor the facile synthesis of deubiquitinase substrates, Chembiochem : a European journal of chemical biology15:37-41.

24. Wang, X. S., Lee, Y. J., and Liu, W. R. (2014) The nitrilimine-alkene cycloaddition is an ultra rapid click reaction,Chemical communications 50:3176-3179.

25. Zeng, Y., Wang, W., and Liu, W. R. (2014) Towards reassigning the rare AGG codon in Escherichia coli,Chembiochem : a European journal of chemical biology 15:1750-1754.

26. Zhang, Y., Chen, X., Lian, H., Liu, J., Zhou, B., Han, S., Peng, B., Yin, J., Liu, W., and He, X. (2014) MicroRNA-503 acts as a tumor suppressor in glioblastoma for multiple antitumor effects by targeting IGF-1R, Oncologyreports 31:1445-1452.

D. Current Research SupportWelch Research Grant A-1715 (Liu, PI) $150,000 06/01/2012-05/30/2014 “Biosensors for Small Molecules and Enzymes”

NIH-1R01CA161158-01 (Liu, PI) $1,483,085 07/01/2011-04/30/2016 “Phage display with two genetically incorporated noncanonical amino acids”

NSF CAREER Award CHE-1148684 (Liu, PI) $575,000 04/01/2012-03/31/2017 Site-specific dual-labeling of a protein through two genetically incorporated noncanonical amino acids

Principal Investigator: LOOPSTRA, Carol A.

PHS 398/2590 (Rev. 09/04) Page 1 Biographical Sketch Format Page



NAME Loopstra, Carol A.


eRA COMMONS USER NAME EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)


Oregon State University B.Sc. 1979 Forest Management Oregon State University M.Sc. 1984 Forest Science North Carolina State University Ph.D 1992 Genetics and Forestry A. Positions and Honors.

2001-present Associate Professor, Dept. of Ecosystem Science and Management, Texas A&M University, College Station, TX, USA

2002-2006 Associate Department Head for Graduate Programs, Dept. of Forest Science, Texas A&M University

1995-2001 Assistant Professor, Dept. of Forest Science, Texas A&M University 1995-present Member of the Faculty of Molecular and Plant Sciences, Texas A&M University 1995-present Member of the Faculty of Genetics, Texas A&M University 2000-present Member of the Faculty of Biotechnology, Texas A&M University 1993 - 1994 Research Officer, The University of Queensland, Brisbane, Australia* 1992 - 1993 Research Fellow, Griffith University, Brisbane, Australia*

• These were the same postdoctoral position. Our university affiliation changed. B. Selected peer-reviewed publications (in chronological order).

Neale DB, Wegrzyn JL, Stevens KA, Zimin A, Puiu D, Crepeau M, Cardeno C, Koriabine M, Holtz-‐‑Morris AE, Liechty JD, MartínezGarcía PJ, Vasquez-Gross HA, Lin BY, Zieve JJ, Dougherty WM, Fuentes-‐‑Soriano S,Wu L,Gilbert D,Marçais G, Roberts M, Holt C,Yandell M, Davis JM, Smith K, Dean JFD, Lorenz W, Whetten RW Sederoff R, Wheeler N , McGuire PE, Main D, Loopstra CA , Mockaitis K, deJong P, Yorke JA , Salzberg SL, Langley CH. (2014) Decoding the massive genome of loblolly pine using haploid DNA and novel assembly strategies. Genome Biology 15:R59.

Wegrzyn JL, Liechty JD, Stevens KA, Wu L-S, Loopstra CA, Vasquez-Gross H, Dougherty WM, Lin BY, Zieve JJ, MartínezGarcía PJ, Holt C, Yandell M, Zimin A, Yorke JA, Grepeau M, Puiu D, Salzberg SL, de Jong, P, Mockaitis K, Main D, Langley CH, Neale DB. (2014) Unique features of the loblolly pine (Pinus taeda L.) megagenome revealed through sequence annotation. Genetics 196:891-909.

Eckert AJ, Wegrzyn JL, Liechty JD, Lee JM, Cumbie WP, Davis JM, Goldfarb B, Loopstra CA, Palle SR, Quesada T, Langley CH, Neale DB. (2013) The evolutionary genetics of the genes underlying phenotypic associations for loblolly pine (Pinus taeda, Pinaceae). Genetics 195: 1353-1372.

Palle SR, Seeve CM, Eckert AJ, Wegrzyn JL, Neale DB, Loopstra CA. (2013) Association of loblolly pine xylem development gene expression with single nucleotide polymorphisms. Tree Physiology 33:763-774

Palle SR, Seeve CM, Eckert AJ, Cumbie WP, Goldfarb B, and Loopstra CA. (2011) Natural variation in expression of genes involved in xylem development in loblolly pine (Pinus taeda L.). Tree Genetics and Genomes 7: 193-206

Principal Investigator: LOOPSTRA, Carol A.

PHS 398/2590 (Rev. 09/04) Page 2 Continuation Format Page

Kovach AS, Wegrzyn JL, Parra G , Holt C, Bruening GE, Loopstra CA, Hartigan J, Yandell M, Langley CH, Korf I, Neale DB (2010) The Pinus taeda genome is characterized by diverse and highly diverged repetitive sequences. BMC Genomics 11:420 doi:10.1186/1471-2164-11-420

Sathyan P, Newton RJ, and Loopstra CA (2005) Genes induced by WDS are differentially expressed in two populations of aleppo pine (Pinus halepensis). Tree Genetics and Genomes 1(4):166-173

Yang S-H and Loopstra CA (2005) Seasonal variation in gene expression for loblolly pines (Pinus taeda L.) from different geographical regions. Tree Physiology 25:1063-1073

Yang S-H, Wang H, Sathyan P, Stasolla C, and Loopstra CA (2005) Real-time RT-PCR analysis of loblolly pine (Pinus taeda L.) arabinogalatactan protein and arabinogalactan-protein-like genes. Physiologia Plantarum 124: 94-126

Yang S-H, van Zyl L, No E-G, and Loopstra CA (2004) Microarray analysis of genes preferentially expressed in

differentiating xylem of loblolly pine (Pinus taeda). Plant Science 166:1185-1195

Zhang Y, Brown G, Whetten R, Loopstra CA, Neale D, and Sederoff RR. (2003) An arabinogalactan-protein associated with secondary cell wall formation in differentiating xylem of loblolly pine. Plant Molecular Biology – 52: 91-102

No E-G and Loopstra C.A. (2000) Hormonal and developmental regulation of two loblolly pine xylem arabinogalactan-proteins. Physiologia Plantarum – 110: 524-529.

No E-G, Zhou Y, and Loopstra CA. (2000) Sequences upstream and downstream of two xylem-specific pine genes influence their expression. Plant Science 160: 77-86.

Loopstra CA, Puryear JD, and No E-G. (2000) Purification and cloning of an arabinogalactan-protein from xylem of loblolly pine. Planta –210: 686-689

Loopstra C, Mouradov A, Vivian-Smith A, Glassick T, Gale B, Southerton S, Marshall H, and Teasdale R. (1998) Two Pinus radiata endo-b-1,4-glucanases are associated with rapidly growing reproductive structures. Plant Physiology 116: 959-967.

Wang H and Loopstra C (1998) Cloning and characterization of a cellulose synthase cDNA (Accession No.AF081534) from xylem of hybrid poplar (Populus tremula X Populus alba). (PGR98-179) Plant Physiol. 118: 1101

Loopstra CA and Sederoff RR. (1995) Xylem-specific gene expression in loblolly pine. Plant Molecular Biology 27: 277-291.

Loopstra CA, Weissinger AK and Sederoff RR (1992) Transient gene expression in differentiating pine wood using microprojectile bombardment. Can. J For. Res. 22: 993-996.

Loopstra CA, Stomp A-M and Sederoff RR (1990) Agrobacterium mediated DNA transfer in sugar pine. Plant Molecular Biology. 15: 1-9.

Stomp A-M, Loopstra CA, Chilton WS, Sederoff RR and Moore L. (1990) Agrobacterium tumefaciens in Pinus. Plant Physiology. 92: 1226-1232.

Loopstra CA and Adams WT (1989) Patterns of variation in first year seedling traits within and among Douglas-fir breeding zones in southwest Oregon. Silvae genetica 38(5-6): 235-243.

Adams WT, Neale DB and Loopstra CA (1988) Verifying controlled crosses in conifer tree-improvement programs. Silvae Genetica 37: 147-152.

Alden J and Loopstra CA (1987) Genetic diversity and population structure of Picea glauca on an altitudinal gradient in interior Alaska. Can. J For. Res. 17: 1519-1526.

Principal Investigator/Program Director (Last, First, Middle): MAGILL Clint W.




NAME Magill, Clint .


eRA COMMONS USER NAME EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)


University of Illinois B.Sc. 1963 Agricultural Science Cornell University Ph.D. 1968 Genetics

University of Minnesota Postdoctoral Training 1967-69 Genetics

A. Positions and Honors Employment 1969-75 Assistant Professor, Dept. of Plant Sciences, Texas A&M University 1975-1989 Associate Professor, Dept. of Plant Sciences became Plant Pathology & Microbiology, TAMU 1989- Professor, Departent of Plant Pathology & Microbiology 1969- Member, Faculty of Genetics 1994- Member, Molecular and Environmental Plant Sciences (MEPS) 2005- Faculty, Masters in Biotechnology Program Other Experience and Professional Memberships Classroom Teaching (Current on an annual basis): Genetics 310, Principles of Heredity; Genetics 603 Introductory Graduate Genetics; BESC 481 and GENE 482, Undergraduate Seminars, Plant Pathology 610, Host Resistance Member, American Association for the Advancement of Science & American Phytoathology Society Editorial Advisory Board, Physiological and Molecular Plant Pathology Honors 1986: TAMU-COALS Award for Excellence for Undergraduate Teaching 2008-2009 Speaker, TAMU Faculty Senate 2009: Named a Fellow of the American Association for the Advancement of Science B. Selected peer-reviewed publications (Postdocs and Graduate Students as shown)

Magill, C.W. 2013 Bridging Classical and Molecular Genetics of Sorghum Disease Resistance, In Plant Genetics and Genomics: Crops and Models, Vol. 11 “Genomics of the Saccharinae” ed. Patterson, A.H., Ch. 15, pp347-367. Springer

Little, C.R., Perumal, R., Tesso, T., Prom, L.K., Odvody, G.N., and Magill, C.W. 2012. Sorghum pathology and biotechnology - A fungal disease perspective: Part I. Grain mold, head smut, and ergot. The European Journal of Plant Science and Biotechnology 6: 10-30.

Tesso, T., Perumal, R., Little, C.R., Adeyanju, A., Radwan, G., Prom, L.K., and Magill, C.W. 2012. Sorghum pathology and biotechnology - A fungal disease perspective: Part II. Anthracnose, stalk rot, and downy mildew. The European Journal of Plant Science and Biotechnology 6: 31-44.

L. K. Prom,, R. Perumal,, SR Erattaimuthu,, CR Little, E-G No, J. E. Erpelding, W. L. Rooney, G. N. Odvody and C. W. Magill (2012) Genetic diversity and pathotype determination of Colletotrichum sublineolum isolates causing anthracnose in sorghum. European Journal of Plant Patholgy 133:671–685

Principal Investigator/Program Director (Last, First, Middle): MAGILL Clint W.


Radwan, GL, Isakeit, T, Magill, CW, Perumal, R,.Prom, LK and Little, CR (2011) Screening exotic sorghum germplasm, hybrids and elite lines for resistance to a new virulent pathotype (P6) of Peronoslcerospr sorghi causing downy mildew. Plant Health Progress (online) doi:10.1094/PHP-2011-0323-01-RS

Prom. LK, Perumal, R., Erattainmuthu, SR, Erpelding, JE, Montes, N, Odvody, GN., Greenwald, C. Jin Z., Frederiksen, R, and Magill, CW (2011) Virulence and Molecular Genotyping Studies of Sporisorium reilianum Isolates in Sorghum. Plant Disease 95:523-529.

Prom, L. K., Perumal, R., Erpelding, J. E., Isakeit, T., and Montes, N., and Magill, C. W. 2009. A pictorial technique for mass screening of sorghum germplasm for anthracnose resistance. The Open Agric. J. 3:20-25

Katilé, SO, Perumal, R, Rooney, WL Prom, LK, Magill, C 2009 Expression of pathogenesis-related protein PR-10 in sorghum floral tissues in response to inocluation with Fusarium thapsinum and Curvularia lunata Mol. Plant Pathol. 11:93-103.

Little, C.R., and Magill, C.W. 2009. The grain mold pathogen, Fusarium thapsinum, reduces caryopsis formation in Sorghum bicolor. Journal of Phytopathology 157: 518-519.

Ramasamy, P, Menz, MA, Mehta, PJ, Katile, S, Gutierrez Rojas, LA, Klein, RR, Klein, PE, Prom, LK, Schlueter, JA, Rooney WL, & Magill, CW 2009. Molecular mapping of Cg1, a gene for resistance to anthracnose (Colletotrichum sublineolum) in sorghum. Euphytica 165:597-606.

Perumal, R, Nimmakayala, P, Erattaimuthu, SR, No, E-G, Reddy,UK, Prom, LK, Odvody, GN, Luster, D. and Magill, CW. (2008) Simple sequence repeat markers useful for sorghum downy mildew (Peronosclerospora sorghi) and related species. BMC Genetics 9:77 http://www.biomedcentral.com/1471-2156/9/77

Liu, J., Stipanovic, R.D., Bell, A.A., Puckhaber, L.S., and Magill, C.W. (2008) Stereospecfific coupling of hemigossypol to form (+)-gossypol in moco cotton. Phytochemistry 69:3038-3042. -

Perumal,, R., Krishnaramanujan, R., Menz, M.A., Katilé, S., Dahlberg, J., Magill, C.W., and Rooney, W.R. (2007) Genetic Diversity among Sorghum Races and Working Groups Based on AFLPs and SSRs. Crop Sci 47:1375-1383.

Ramasamy, P., Frederiksen, R. A., Prom, L. K., and C. W. Magill (2007) “Head Smut” in Thakur, R. P., Reddy, B. V. S. and K Mathur (eds.) Screening Techniques for Sorghum Diseases. Information Bulletin No. 76. ICRISAT, Patancheru 502 324, Andhra Pradesh, India

Sabry, A.B., Jeffers, D.,Vasal, S.K., Frederiksen, R., and Magill, C.W. (2006) A region of maize chromosome 2 affects response to downy mildew pathogens. Theor. Appl. Genet. 113:321-330.

Perumal, R. Isakeit, T., Menz, M., Katilé, S., No, E-G, Magill, C.W. (2006) Characterization and genetic distance analysis of isolates of Peronosclerospora sorghi using AFLP fingerprinting. Mycological Res. 110:471-478.

He, B., Magill, C. & Starr, J. (2005) Laser capture microdissection and real-time PCR for measuring mRNA in giant cells induced by Melodogyne javanica. Journal of Nematology 37: 308-31.

Bolek, Y., El Zik, K., Pepper, A.E., Bell, A.A., Magill, C.W., Thaxton, P.M., and Reddy, O.U.K. 2005. Mapping of verticillium wilt resistance genes in cotton. Plant Science 168: 1581-1590.

Benedict, C.R., Martin, G., Liu, J., Puckhaber, L. and Magill C. W. 2004. Terpenoid aldehyde formation and lysigenous gland storage sites in cotton: Variant with mature glands but suppressed levels of terpenoid aldehydes Phytochemistry 65:1351-1359.

Little, C. R. and Magill, C. W. 2004. Elicitation of defense response genes in Sorghum bicolor (L.) Moench in response to infection by Fusarium thapsinum and Curvularia lunata at anthesis. Mol. & Physiol. Plant Patholgy 63: 271 - 279.

Martin, G., Liu, J., Benedict, C., Stipanovic, R., Magill, C. 2003. Reduced levels of cadinane sesquiterpenoids in cotton plants expressing antisense (+)-d-cadinene synthase. Phytochemistry 62:31-38.

Liu, J., Benedict, C, Bell, AA, Stipanovic, RD, Magill, CW, 2002. Cloning and Expression of Desoxyhemigossypol-6-O-Methyltransferase from Cotton (Gossypium barbadense) Journal of Agricultural & Food Chemistry 50: 3165-3172

Cui, Y., Bell, A. A., Puckhaber, L., Joost, O., and Magill, C. 2000. Induction of defense genes in wilt-resistant and susceptible cotton cultivars by Verticillium and Fusarium. Physiol. & Mol. Plant Pathology 56:25-31.

Naidoo, G., R. A. Frederiksen, J. H. Torres-Montalvo, and C. W. Magill (1999) Maize and sorghum isolates of Sporisorium reilianum differ in electrophoretic karyotype MMPOL. (http://www.bspp.org.uk/mppol/1999/0419Naidoo)

Boora, Khazan S., Richard A. Frederiksen and Clint W. Magill (1999) A molecular marker that segregates with sorghum leaf blight resistance in one cross is maternally inherited in another. Molecular and General Genetics 261:317-322.

CURRICULUM VITA

NAME AND TITLE: JULIAN CREIGHTON MILLER, JR. Professor of Horticulture, of Genetics, and of Biotechnology

Department of Horticultural Sciences Texas A&M University, College Station, Texas 77843-2133 (979) 845-3828; FAX (979) 845-0627; E-Mail: [email protected] Website: potato.tamu.edu EDUCATION: Ph.D. (Horticulture, Breeding-Genetics), Michigan State University,

1972 M.S. (Horticulture), Louisiana State University, 1967 B.S. (General Studies), Louisiana State University, 1965 PROFESSIONAL SUMMARY:

Dr. Miller is Professor in the Department of Horticultural Sciences at Texas A&M University, College Station. He is Director of the Texas Potato and Legume Improvement Programs and has developed or co-developed 19 new potato and legume varieties. He has authored/co-authored more than 400 scientific publications. Dr. Miller has taught six different undergraduate and graduate courses. He was the 1992 recipient of the prestigious L.M. Ware Distinguished Teaching Award from the Southern Region American Society for Horticultural Science. In 2005, he received the Distinguished Achievement Award in Teaching from the Association of Former Students of Texas A&M University. He is a Past President of the American Society for Horticultural Science – Southern Region and of The Potato Association of America, and an Honorary Life Member (Fellow) of the latter organization. He is also a Fellow of the American Society for Horticultural Science and former Vice-President for Research. He is the 2009 recipient of the Outstanding Researcher Award presented by the American Society for Horticultural Science and of the Outstanding Paper Award, 2010, Potato Association of America.

PROFESSIONAL AND ACADEMIC EXPERIENCE:

Graduate Faculty of Biotechnology, 2010 - Graduate Faculty of Molecular and Environmental Plant Sciences, 1984- 2008

Professor, Texas A&M University, 1982- Graduate Faculty of Genetics, 1981- Unit Head, Montague Fruit Demonstration Center, 1980-83 Interim Head, Horticultural Sciences Department, 1980-83 Associate Professor, Texas A&M University, 1977-82 Assistant Professor, Texas A&M University, 1975-77 Assistant Professor, Texas Agricultural Experiment Station, Lubbock, 1972-75 Research Assistant, Michigan State University, 1968-72 Research Assistant, University of Wisconsin, 1967-68 Research Assistant, Louisiana State University, 1965-67

mailto:[email protected]

TEACHING (COURSES TAUGHT) AND RELATED ACTIVITIES: Concepts of Horticultural Science, Commercial Vegetable Production, Plant Breeding

404/Genetics 404, Postharvest Physiology of Horticulture Crops, Senior Seminar, Problems in Horticulture (undergraduate & graduate), Problems in Genetics (undergraduate & graduate), Professional Internship, Special Topics in Vegetable Breeding & Genetics, and Theory of Research; Founder and Advisor, Horticultural Sciences Graduate Student Organization, TAMU, 1975-85; TAMU University Mentor (Undergraduate Counselor) 1987-

GRANTS RECEIVED (2010-2013)

1. Specialty Crop Research Initiative. Development of an Integrated Research and

Management Program for Zebra Chip of Potato. 2009-13. $243,000 (Total $6.9 million) (2009 $47,163).

2. USDA National Institute of Food and Agriculture. Special Research Grants Program, Potato Research. Potato Breeding and Cultivar Development in the Southwest. 2010. $45,800. (With Colorado State University and University of California - total - $137,521) (no indirect costs permitted).

3. TDA Grant for Zebra Chip Research. Evaluating potato germplasm for

resistance/tolerance to Zebra Chip. 2010. $41,500 (With AgriLife Research cooperators – Total - $800,000).

4. USDA National Institute of Food and Agriculture. Special Research Grants Program,

Potato Research. Potato Breeding and Cultivar Development in the Southwest. 2011. $60,000. (With Colorado State University and University of California - total - $186,088) (no indirect costs permitted).

5. TDA Grant for Zebra Chip Research. Evaluating potato germplasm for

resistance/tolerance to Zebra Chip. 2011. $10,000 (With AgriLife Research cooperators – Total - $400,000).

6. Specialty Crop Research Initiative. Development of an Integrated Research and

Management Program for Zebra Chip of Potato. 2011. $47,163. 7. USDA National Institute of Food and Agriculture. Special Research Grants Program,

Potato Research. Potato Breeding and Cultivar Development in the Southwest. 2012. $56,000. (With Colorado State University and University of California - total - $168,000) (no indirect costs permitted). AgriLIFE Grant for Zebra Chip Research. Evaluating potato germplasm for resistance/tolerance to Zebra Chip. 2012. $15,000.

8. USPB Grant for National Chip Breeders Trial – Texas. 2012. $10,000.

9. USDA National Institute of Food and Agriculture. Special Research Grants Program, Potato Research. Potato Breeding and Cultivar Development in the Southwest. 2013. $48,000. (With Colorado State University and University of California - total - $144,010) (no indirect costs permitted).

10. USPB Grant for National Chip Breeders Trial – Texas. 2013. $10,000.

PUBLICATION TOTAL:

Total 417: 68 refereed journal articles, 6 book chapters, 27 proceedings, 13 referred variety release articles, 2 theses, 140 technical articles, 128 abstracts, 2 websites, and 31 national and international invited papers.

SELECTED PUBLICATIONS (2010-2014):

Refereed

1. Brown, C. R., K.G. Haynes, M. Moore, M.J. Pavek, D.C. Hane, S.L. Love, R.G. Novy, and J.C. Miller, Jr. 2010. Stability and broad-sense heritability of mineral content in potato: Iron. Amer. J. Potato Res. 87:390-396.

2. Reddivari, L., J. Vanamala, S.H. Safe, and J.C. Miller, Jr. 2010. The bioactive

compounds α - chaconine and gallic acid in potato extracts decrease survival and induce apoptosis in LNCaP and PC3 prostate cancer cells. Nutr. and Cancer. 62(5): 601-610.

3. Blessington, T., M.N. Nzaramba, D.C. Scheuring, A.L. Hale, L. Reddivari, and J.C. Miller, Jr., 2010. Cooking methods and storage treatments of potato: Effects on carotenoids, antioxidant activity, and phenolics. Amer. J. Potato Res. 87:479-491. (Outstanding Paper Award 2010, Potato Association of America).

4. Jansky, S. and J.C. Miller,Jr. 2010. Evaluation of Verticillium wilt resistance in Russet Norkotah and six strain selections. Amer. J. Potato Res. 87:492-496.

5. Brown, C. R., K.G. Haynes, M. Moore, M.J. Pavek, D.C. Hane, S.L. Love, R.G.

Novy, and J.C. Miller, Jr. 2011. Stability and broad-sense heritability of mineral content in Potato: Zinc. Amer. J. Potato Res. 88:238-244.

6. Butler, C.D., B. Gonzalez, M.L. Keremane, R.F. Lee, R.G. Novy, J.C. Miller, and

J.T. Trumble. 2011. Behavioral responses of adult potato psyllid, Bactericera cockerelli (Hemiptera: Triozidae), to potato germplasm and transmission of Candidatus Liberibacter psyllaurous. Crop Prot. 30:1233-1238.

7. Brown, C. R., K.G. Haynes, M. Moore, M.J. Pavek, D.C. Hane, S.L. Love, R.G.

Novy, and J.C. Miller, Jr. 2012. Stability and broad-sense heritability of mineral content in potato: Calcium and Magnesium. Amer. J. Potato Res. 89:225-261.

8. Bamberg, J.and J.C. Miller, Jr. 2012. Comparisons of ga1 with other reputed

gibberellin mutants in potato. Amer. J. Potato Res. 89:142-149.

9. Brown, C.R., I. Vales, S. Yilma, S. James, B. Charlton, D. Hane, M. Pavek, R. Knowles, J. Stark, R. Novy, J. Whitworth, J.C. Miller, Jr., D. Holm, and R. Navarre. 2012. “AnnaRosa”, a red skinned, red flesh fingerling with high phytonutrient value. Amer. J. Potato Res. 89:255-261.

10. M. Ndambe Nzaramba, Douglas C. Scheuring, Jeffrey W. Koym, and J. Creighton

Miller, Jr. 2013. Relationships among Antioxidant Activity, Phenolics and Specific Gravity in Potato (Solanum tuberosum L.) Cultivars Grown in Different Environments. Amer. J. Potato Res. 90:541-550.

11. Diaz-Montano, J., B.G. Vindiola, N. Drew, R.G. Novy, J.C. Miller, Jr, and J.T.

Trumble. 2014. Resistance of Selected Potato Genotypes to the Potato Psyllid (Hemiptera: Triozidae). Amer. J. Potato Res. 91: 363-367.

12. Brown, C.R., K.G. Haynes, M. Moore, M.J. Pavek, D.C. Hane, S.L. Love, R.G.

Novy, and J.C. Miller, Jr. 2014. Stability and Broad-sense Heritability of Mineral Content in Potato: Copper and Sulfur. Amer. J. Potato Res. 91:618-624.

13. M. Ndambe Nzaramba, Douglas C. Scheuring, John B. Bamberg, Scott A. Senseman,

and J. Creighton Miller, Jr. 2014. Total Glycoalkaloids, Antioxidant Activity, and Phenolic Levels in Solanum microdontum and Solanum jamesii Accessions. Amer. J. Potato Res. 90.(In review).

Abstracts

1. Holm, D.G., S.Y.C. Essah, J.C. Miller, Jr., R.G. Wilson, and J.J. Nunez. 2011.

Potato breeding and cultivar development in the Southwest. Amer. J. Potato Res. 88:45. (Abstr).

2. Turner, S.D., L. Reddivari, R. Navarre, D.C. Scheuring, and J.C. Miller, Jr. 2011.

Effects of Bioactive Compounds from Different Potato Genotypes on Prostate Cancer Development in Athymic Nude Mice. National Association of Plant Breeders, 2011 Annual Conference, Texas A&M University, College Station, May 23-25, Abstracts, p57. (Abstr).

3. Pierson, E.A., D.C. Scheuring, D.C. Henne, J.L. Jifon, J.G. Levy, S.D. Turner, and

J.C. Miller, Jr. 2011. Evaluation of Potentially Zebra Chip-tolerant Advanced Selections in Insect Preference Trials. Amer. J. Potato Res. 89:44-45 (Abstr).

4. Turner, S.D., L. Reddivari, R. Navarre, D.C. Scheuring, and J.C. Miller, Jr. 2011.

Effect of Purple and White Potato Extracts on Prostate Cancer Development in Athymic Nude Mice. Amer. J. Potato Res. 89:49. (Abstr).

Miscellaneous Publications

1. Miller, C., J. Koym, and D. Scheuring. 2010. 2010 Field Day Handbook. July 15,

2010. Texas Potato Variety Development Program. Texas AgriLife Research, College Station and Lubbock. 33p.

2. Miller, C., D. Scheuring, and J. Koym. 2010. Texas Potato Breeding Report, 2009.

Texas AgriLife Research, College Station and Lubbock. 386p.

3. Miller, J.C., Jr., J.W. Koym, D.C. Scheuring, and J.P. Miller. 2010. Southwest Regional Potato Variety Trial Report 2009. Texas AgriLife Research, College Station and Lubbock. 22p.

4. Miller, C., D. Scheuring, and J. Koym. 2010. Texas Potato Breeding Report, 2009.

Texas AgriLife Research, College Station and Lubbock. 386p.


Principal Investigator/Program Director (Last, First, Middle): MIRANDA, Rajesh C.



NAME

Rajesh C. Miranda, Ph.D. POSITION TITLE

Professor eRA COMMONS USER NAME

rmiranda EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)


St. Xavier’s College, Bombay, India B.A. 1982 Psychology Bombay University, Bombay, India M.A. 1984 Clinical Psychology University of Rochester, Rochester, N.Y. M.A. 1987 Biopsychology University of Rochester, Rochester, N.Y. M.S. 1988 Neurobiology University of Rochester, Rochester, N.Y. Ph.D. 1989 Biopsychology/Neurobiol. Columbia University, Col. Physicians & Surgeons, NY Post-Doctoral 1989-1994 Neurobiology

A. Personal Statement: My primary research interest is in maternal-fetal health, with a focus on fetal brain development, stem cell programming and the biology of microRNAs. In 2007, we were the first research group to identify microRNAs as a target for teratogens and drugs of abuse like alcohol (PMCID: 2915840). Since then, we have focused on identifying additional teratogen-sensitive miRNAs associated with the maturation of fetal neural stem cells, as well as miRNAs associated with neural adaptation to degeneration. My laboratory is also currently using a variety of high-throughput screening approaches to identify vascular circulating microRNA biomarkers for ethanol consumption and for fetal ethanol exposure (as part of a consortium, U24 AA014811). I expect that our research on microRNAs and their mRNA targets will uncover novel mechanisms of fetal brain adaptation and plasticity that are amenable to therapeutic intervention. B. Positions and Honors 1983-1984 St. Xavier’s College, Bombay India, University Grants Commission teaching assistant 1983 Psychaid, Bombay, India, Clinical assistant, psychological testing 1984-1989 University of Rochester, Depts. of Psychology and Neuroscience: Teaching assistant. 1989-1992 Columbia University College of Physicians and Surgeons, Center for Reproductive Sciences: Post-

doctoral research Scientist 1990-1994 Columbia University College of Physicians and Surgeons, Instructor, Medical Neuroanatomy 1992-1994 Columbia University, Center for Reproductive Sciences: Associate Research Scientist. 1995-2000 Texas A&M University, Dept. Human Anatomy and Medical Neurobiology, Assistant Professor. 2000-2009 Texas A&M, Health Science Center, Dept. Neurosci & Expt. Therapeutics, Associate Professor 2009- Texas A&M Health Science Center, Professor 2005- Texas A&M University, Department of Psychology, Adjunct Professor 1995-present Member of the Faculties of Neuroscience, Reproductive Biology and Toxicology at TAMU 1999-present Member, Center for Environmental and Rural Health, Texas A&M University 2002-2003 Ad-hoc reviewer, NIH, ALTX-3 and NAL study section 2004-2007 Member, NIH, NAL (Neurotoxicology and Alcohol) study section 2006-2009 Ad. Hoc. Member, NIH AA-1, ZAA1-BB98, NCF, MNG & AA-4 study sections 2009-2012 Member, NIH AA-4 study section. 2012- 2015 Chair, AA-4 study section 2009-2011 Treasurer, vice president Fetal Alcohol Spectrum Disorders Study Group (FASDSG) 2011-2012 President, Fetal Alcohol Spectrum Disorders Study Group 2012- Member of the Steering Committee on FASD prevention at the Texas PHS Office for Prevention of

Developmental Disabilities

Principal Investigator/Program Director (Last, First, Middle):


Relevant Publications: 1. Balaraman S, Lunde ER, Sawant OB, Cudd TA, Washburn SE, Miranda RC (2014) Maternal And Neonatal Plasma

MicroRNA Biomarkers For Fetal Alcohol Exposure In An Ovine Model. Alcoholism: Clinical And Experimental Research:In Press. PMCID in progress.

2. Bake S, Tingling J, Miranda RC (2012) Ethanol exposure during pregnancy persistently attenuates cranially-directed blood flow in the developing fetus: Evidence from ultrasound imaging in a murine second trimester equivalent model. Alcohol Clin Exp Res. May;36(5):748-58. PMCID: PMC3297711

3. Balaraman S, Winzer-Serhan UH, Miranda RC (2012) Opposing actions of ethanol and nicotine on microRNAs are mediated by nicotinic acetylcholine receptors in fetal cerebral cortical-derived neural progenitor cells. Alcohol Clin Exp Res. Oct;36(10):1669-77. PMCID: PMC3390449

4. Sathyan P, Golden, HB, Miranda RC (2007) Competing interactions between microRNAs determine neural progenitor survival and proliferation following ethanol exposure: Evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium. Journal of Neuroscience Aug 8;27(32):8546-57. PMCID: PMC2915840

5. Santillano DR, Kumar LK, Prock TL, Tingling J, Miranda RC (2005) Ethanol induces cell-cycle activity and reduces stem cell heterogeneity in cerebral cortical neuroepithelial precursors. Biomed Central: Neuroscience 6:59. PMCID: PMC1249578

6. Selvamani A, Sathyan P, Miranda RC, Sohrabji F (2012) An antagomir to microRNA Let7f promotes neuroprotection in an ischemic stroke model. PLoS ONE 7(2):e32662. PMCID: PMC3290559.

7. Miranda, RC (2012) MicroRNAs and fetal brain development: implications for ethanol teratology during the second trimester period of neurogenesis. Front Genet. 3: 77. PMCID: PMC3353139.

8. Sudheendran N, Bake S, Miranda RC, Larin KV (2013) Comparative assessments of the effects of Alcohol Exposure on Fetal Brain Development Using Optical Coherence Tomography and Ultrasound Imaging. Journal of Biomedical Optics 18(2):20506. PMCID: PMC3563965.

9. Selvamani A, Williams M, Miranda RC, Sohrabji F (2014) Circulating miRNA profiles provide a biomarker for severity of stroke outcomes associated with age and sex in a rat model. Clin Sci:In Press.

D. Other Support: AA13440 (P.I.: Rajesh C. Miranda) 03/01/2002-08/31/2014 NIAAA Fetal Alcohol exposure and neurodevelopment I serve as PI for this project. AA13440 investigates (1) the role of alcohol exposure on the control of receptor-neural stem cell maturation. (2) The involvement of miRNAs as critical mediators of ethanol’s effects on stem cell maturation. 1R01NS074895 (Sohrabji, PI) 9/01/2011- 05/30/2016 NIH Neuroprotection in the Aging Female Brain I serve as a co-investigator on this project. The overall goal of this application is determine the interaction of estrogen and IGF-1 in the context of stroke and neuroprotection in middle age females, using an animal model U01 AA014835-09 (Chambers, PI) 2012-2017 NIH Early Identification of Affected Children and Risk Factors for FASD in Ukraine I serve as a co-investigator on this proposal. My role will be to screen for plasma miRNA biomarkers for alcohol exposure in mothers and children in an FASD cohort in the Ukraine. This proposal will correlate the expression of miRNA biomarkers with other epigenetic markers and anatomical markers of fetal alcohol exposure.

Principal Investigator MULLET, John E.




NAME Mullet, John E.


eRA COMMONS USER NAME RLINTS EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)


Colgate University, Hampton, New York B.Sc. 1972-1976 Biology University of Illinois, Champaign Ph.D. 1976-1980 Cell Biology

A. Positions and Honors.Positions and Employment1999-2005 Director, Institute for Plant Genomics and Biotechnology, Texas A&M University 1993-1999 Director, Crop Biotechnology Center, Texas A&M University 1991-prsesent Professor, Department of Biochemistry and Biophysics, Texas A&M University 1986-1991 Associate Professor, Department of Biochemistry and Biophysics, Texas A&M

University 1983-1986 Assistant Professor, Department of Biochemistry & Biophysics, Texas A&M

University 1980-1983 NIH Postdoctoral Fellow, Rockefeller University 1978-1980 NATO research at the CNRS, France, 1980; Japan, 1978

B. Selected peer-reviewed publications (in chronological order).PUBLICATIONS (Total 180):

Borrell, AK, Mullet, JE, George-Jaeggli, B, Oosterom, EJV, Hammer, GL, Klein, PE, Jordan, DR (2014) Drought adaptation of stay-green sorghum is associated with canopy development, leaf anatomy, root growth, and water uptake. Journal of Experimental Botany (doi:10.1093/jsb/eru232)

Mullet, J.E., Morishige, D.T., McCormick, R., Truong, S., Hilley, J, McKinley, B., Anderson, R., Olson, S., and Rooney, W. (2014) Energy Sorghum – A Genetic Model for the Design of C4 Grass Bioenergy Crops. Journal of Experimental Botany (doi:10.1093/jsb/eru229)).

Yang, S., Murphy, R.L., Morshige, D.T., Klein, P.E., Rooney, W.L., and Mullet, J.E. (2014) Sorghum Phytochrome B Inhibits Flowering in Long Days by Activating Expression of SbPRR37 and SbGHD7, Repressors of SbEHD1, SbCN8 and SbCN12. PloS One (submitted)

Yang, S., Weers, B.W., Morshige, D.T., Mullet, J.E. (2014) CONSTANS is a Photoperiod Regulated Activator of Flowering in Sorghum. BMC Plant Biology (In press).

Rebecca L. Murphy, Daryl T. Morishige, Jeff A. Brady, William L. Rooney, Shanshan Yang, Patricia E. Klein, John E. Mullet (2014) Ghd7 (Ma6) Represses Sorghum Flowering in Long Days: Ghd7Alleles Enhance Biomass Accumulation and Grain Production. The Plant Genome (In press, doe:

Principal Investigator MULLET, John E.


10.3835/plantgenome2013.11.0040).

Evans, J.E., McCormick, R.F., Morishige, D., Olson, S.N., Weers, B.D., Hilley, J., Klein, P., Rooney, W., Mullet, J.E. (2013) Extensive Variation in the Density and Distribution of DNA Polymorphism in Sorghum Genomes. PLOS One 8:e79192 .

Morishige, D.T., Klein, P.E., Hilley, J.L., Sahraeian, S.M.E., Sharma, A., and Mullet, J.E. (2013) Digital Genotyping of Sorghum – A Diverse Species with a Repeat-Rice Genome. BMC Genomics 14: 448-467.

Olson, Sara, Kimberley Ritter, Jim Medley, Ted Wilson, William Rooney, and John E. Mullet (2013) Energy Sorghum Hybrids: Functional Dynamics of High Nitrogen Use Efficiency. Biomass and Bioenergy 56: 307-316.

Kapanigowda, M.H., Payne, W.A., Rooney, W.L., and J.E. Mullet (2012) Transpirational efficiency in sorghum [Sorghum bicolor (L.) Moench) for increased water-use efficiency and drought tolerance. Journal of Arid Land Studies 22, No 1.

Olson, S.N., Ritter, K., Rooney, W., Kemanian, A., McCarl, B.A., Zhang, Y., Hall, S., Packer, D., and Mullet, J. (2012) High Biomass Yield Energy Sorghum: Developing a Genetic Model for C4 Grass Bioenergy Plants. Biofuels, Bioproducts and Biorefining 6: 640-655 (DOI: 10:1002/bbb)

Murphy, B., Klein, R., Morishige, D., Brady, J.A., Rooney, W. L., Miller, F.R., Dugas, D.D., Klein, P., Mullet, J.E. (2011) Coincident Clock and Light Regulation of Pseudo Response Regulator Protein 37 PRR37 Controls Photoperiodic Flowering in Sorghum. PNAS 108: 16469-16474

Borrell, A., Jordan, D., George-Jaeggli. B., Mace, E., Hamlet, S., Hammer, G., Mclean, G., Van Oosterom, E., Hunt, C., Klein, P., Mullet. J.E. (2010) Fine Mapping Candidate Genes for ‘Stay-Green’ in Sorghum; Simplicity Beyond Complexity? Summer Crops Research Conference.

Murray, S.C., Sharma, A., Rooney, W.L., Klein, P., Mullet, J.E., Mitchell, S.E., Kresovich, S. (2008) Genetic Improvement of Sorghum as a Biofuel Feedstock: I. QTL for Stem Sugar and Grain Nonstructural Carbohydrates. Crop Science 48: 2165-2179.

Murray, S.C., Rooney, W.L., Mitchell, S.E., Sharma, A., Klein, T., Mullet, J.E., Kresovich, S. (2008) Genetic Improvement of Sorghum as a Biofuel Feedstock: II. QTL for Stem and Leaf Structural Carbohydrates. Crop Science 48: 2180-2193

Klein, R.R., Mullet, J.E., Jordan, D.R., Miller, F.R., Rooney, W.L., Menz, M.M., Franks, C.D., Klein, P.E. (2008) The Effect of Tropical Sorghum Conversion and Inbred Development on Genome Diversity as Revealed by High-Resolution Genotyping. Plant Genome 48: S12-26.

Rooney, W.L., Blumenthal, J., Bean, B., Mullet, J.E. (2007) Designing sorghum as a dedicated bioenergy feedstock. Biofuels, Bioproducts and Biorefining 1:147-157.

Yim, Y.-S., Moak, P., Shachez-Villeda, H., Musket, T.A., Close, P., Klein, P.E., Mullet, J.E., McCullen, M.D., Fang, A., Schaeffer, M.L., Gardiner, J.M., Coe, E.H., Davis, G. L. (2007) A BAC pooling strategy combined with PCR-based screenings in a large, highly repetitive genome enables integration of the maize genetic and physical maps. BMC Genomics 8:47-56.

Curriculum Vitae

Present Position and Address Waithaka Mwangi, Ph.D., Associate Professor, Vaccine Development Office: Rm. 179 VMR-Annex Building; Mail Stop: VTPB Department of Veterinary Pathobiology (VTPB), College of Veterinary Medical and Biomedical Sciences (CVM&BIMS), Texas A&M University College Station, TX 77843-4467 Phone : 979-845-4615 Fax : 979-862-1088 Email : [email protected]

Education:

Degree Conferring Institution Field Year B.S. University of Nairobi, Kenya Biochemistry/Parasitology 1990

Ph.D. Washington State University Immunology 2002 Post-doc Washington State University Immunology 2002 - 2004

Personal Statement:

I am an enthusiastic immunologist and I enjoy teaching, both in class and on the bench, and I believe that motivating students to be engaged and to love learning is the catalyst that is transforming lives and making the world better. For me, there is no better source of joy and gratification in life than imparting knowledge to students to enable them realize their dreams. My research is focused on developing novel strategies for optimizing vaccine efficacy in outbred species. Studies are primarily directed at enhancing in vivo antigen presentation by dendritic cells following immunization. In addition, I am evaluating defined dendritic cell activation factors for their potency in enhancing vaccine immunogenicity in livestock for adjuvant development. Major on-going efforts are directed at generating efficacious vaccines for induction of protection against Bovine Viral Diarrhea Virus (BVDV) in neonates and African Swine Fever Virus.

Professional Experience and Academic Appointments:

2014-Present: Associate Professor and Graduate Faculty, Department of Veterinary Pathobiology, Texas A&M University.

2012-Present: Graduate Faculty, Texas A&M University Professional Program in Biotechnology

2011-Present: Faculty, Texas A&M University Health Science Center School of Graduate Studies.

2005-2014: Assistant Professor (tenure-track) and Graduate Faculty, Department of Veterinary Pathobiology, Texas A&M University.

2004 - 2005: Assistant Professor (non-tenure track) and Graduate Faculty, Department of Veterinary Microbiology and Pathology, Washington State University.

2002 - 2004: Post-Doctoral Research Fellow, Department of Veterinary Microbiology and Pathology, Washington State University.

1997 - 2002: Graduate Research Assistant, Department of Veterinary Microbiology and Pathology, Washington State University.

1990 - 1996: Research Associate, International Livestock Research Institute (ILRI), Nairobi, Kenya.

Awards and Honors:

- College of Veterinary Medicine & Biomedical Sciences Outstanding Scientific ResearchAchievement Award, 2014

- Texas A&M University Montague-Center for Teaching Excellence Scholar Award, 2013- College of Veterinary Medicine & Biomedical Sciences Faculty International Travel

Award, 2012- American Association of Immunologists Travel Award for the Annual Meeting in Miami,

FL. 2007- American Association of Immunologists (AAI)-Federation of American Societies for

Experimental Biology (FASEB) Travel Award for the Annual Meeting in Boston, MA.2006

- American Association of Veterinary Immunologists (AAVI) Travel Award for the 7th

International Veterinary Immunology Symposium in Quebec, Canada, 2004- NIH Immunology Training Grant (Ruth L. Kirsch stein National Research Service

Award), 2003- 2004- Phi Kappa Phi Honor Society, 1998 - Present

Professional Organizations:

1. American Association of Veterinary Immunologists (AAVI), 2010-Present.2. American Association of Immunologists (AAI), 2002-Present.

Editorial Board Austin Virology and Retro Virology Journal

Manuscript Review for Journals:

1. Reviewer Journal of Veterinary Medicine and Animal Health (JVMAH).2. Reviewer Clinical and Vaccine Immunology (CVI).3. Reviewer Vaccine.

Grant Review Committees:

1. NIFA-IBCE: NIFA Exploratory Research Program. Ad hoc reviewer, July 2014.2. NIFA-SBIR: Animal Production & Protection Program. February 20143. BARD: The US-Israel Agricultural Research & Development Fund Ad hoc reviewer.

November 20134. NIFA-SBIR: Animal Production & Protection Program. February 20135. NIFA: US Veterinary Immune Reagent Network’s renewal proposal Ad hoc reviewer,

November 19th, 2009

6. National Institute of Food and Agriculture (NIFA): Animal Health and Well-Being studysection, 2009

Patents:

1. Pub. No.: US 2014/0079704 A1: Overriding pre-existing vaccine-specific neutralizingantibodies to prime and or boost adaptive immunity. Inventor

2. TAMUS 3792: Antibody-guided vaccine targeting chicken generates fast mucosal IgAresponses in the chicken. Co-Inventor

3. TAMUS 3617: Priming rapid and robust IgG responses with a single subcutaneousimmunization in the chicken and potentially other vertebrate species. Co-inventor

Teaching Activities:

I teach one undergraduate and one graduate immunology course in alternate years. In spring of odd years, I teach ‘Introduction to Immunology’ (VTPB409, with honors option; 3 credit course) to undergraduate students. This is a first level immunology course designed for undergraduate students with no previous exposure to the subject. This course is mostly taken by biomedical science students and the goal of this course is to familiarize the students with the basic features of the immune system and how it functions. The demand for this course is increasing as more students are taking it in preparation for attending higher institutes of allied health professions. The course is also taken by some graduate students as well. In spring of even years, I teach ‘Immunology’ (VTMI 649; 3 credit course) to graduate students. This is a first level graduate course whose goal is to familiarize students with the features of the immune system and nomenclature. I also participate in teaching ‘Advanced Immunologic Concepts’ (VTMI 662) to graduate students. This course is offered in the fall of alternate years. In addition, I have offered directed studies to undergraduate and graduate students (VTMI 485, BIMS 491, VTMI 685, and BIOT 685). Furthermore, I train undergraduate students and visiting scholar trainees in my laboratory. I have mentored undergraduate honors research student, Masters and PhD students, Postdocs, and visiting scholars. Currently, I have one MS and two PhD students and I have served in 21 graduate student committees.

Teaching Award: Montague-Center for Teaching Excellence Scholar award, Texas A&M University (2013)

Recent Publications: 1. Bordin, A., C. Brake, K. B. Bagley, J. R. Bourquin, M. Coleman, F. Oliveira, W. Mwangi,

D. N. McMurray, C. C. Love, M. J. B. Felippe, S. D. Pillai, and N. D. Cohen. 2014.Immunogenicity of an Electron-Beam Inactivated Rhodococcus equi Vaccine in NeonatalFoals. PLoS One. Aug 25;9(8):e105367. .

2. Rajput MK, Darweesh MF, Park K, Braun LJ, Mwangi W, Young AJ, and Chase CC. 2014.The effect of Bovine Viral Diarrhea Virus (BVDV) strains on Bovine Monocyte-derivedDendritic Cells (Mo-DC) phenotype and capacity to produce BVDV. Virology Journal,11:44

3. Small CM, Ajithdoss DK, Rodrigues Hoffmann A, Mwangi W, and Esteve-Gassent MD.2014. Immunization with a Borrelia burgdorferi BB0172-Derived Peptide Protects Miceagainst Lyme Disease. PLoS One. 2014 Feb 5;9(2):e88245. PMID: 24505447

4. Gonzalez-Juarrero, M., N. Mima, L.A. Trunck, H.P. Schweizer, R.A. Bowen, K. Dascher,W. Mwangi, and T.M. Eckstein. 2013. "Polar lipids of Burkholderia pseudomallei inducedifferent host immune responses". PLoS ONE. DOI: 10.1371/journal.pone.0080368

5. Wang, F., D. C. Ekiert, I. Ahmad, W. Li, Y. Zhang, A. Torkamani, T. Raudsepp, W.Mwangi, M. F. Criscitiello, I. A. Wilson, P. G. Schultz, and V. V. Smider. 2013. ReshapingAntibody Diversity. Cell 153: 1379-1393. PMID: 23746848.

6. Gabriel Gomez, Jianwu Pei, Waithaka Mwangi, L. Garry Adams, Allison Rice-Ficht, andThomas A Ficht. 2013. Immunogenic and Invasive Properties of Brucella melitensis 16MOuter Membrane Protein Vaccine Candidates identified via a Reverse VaccinologyApproach. PLoS One. 2013;8(3):e59751. PMID: 23533646

7. Leo M. Njongmeta, Jocelyn Bray, Christopher J. Davies, William C. Davis, Christopher J.Howard, Jayne C. Hope, Guy H. Palmer, Wendy C. Brown, and Waithaka Mwangi. 2012.CD205 antigen targeting combined with dendritic cell recruitment factors and antigen-linked CD40L activation primes and expands significant antigen-specific antibody andCD4+ T cell responses following DNA vaccination of outbred animals. Vaccine. 30(9):1624-35. PMID: 22240344.

8. Lilian Flores-Mendoza, Carlos Velazquez, Jocelyn Bray, Leo Njongmeta, WaithakaMwangi, and Jesús Hernández. 2012. Development and Characterization of a MonoclonalAntibody against Porcine CD205. Vet. Immunol Immunopathol. 146:74-80. PMID:22348805.

9. Camilo Pohlenz, Alejandro Buentello, Michael Criscitiello, Waithaka Mwangi, RogerSmith, and Delbert Gatlin III. 2012. Synergies between vaccination and dietary arginine andglutamine supplementation improve the immune response of channel catfish againstEdwardsiella ictaluri. Fish and Shellfish Immunol. 33:543-551. PMID: 22728565.

10. Chang-Hsin Chen, Daad Abi-Ghanem, Suryakant D. Waghela, Wen-Ko Chou, Morgan B.Farnell, Waithaka Mwangi, and Luc R. Berghman. 2012. Immunization of chickens withan agonistic monoclonal anti-chicken CD40 antibody-hapten complex: Rapid and robustIgG response induced by a single subcutaneous injection. J. Immunol Methods. 378(1-2):116-20. PMID: 22366632.

11. Camilo Pohlenz, Alejandro Buentello, Waithaka Mwangi, and Delbert M. Gatlin III. 2012.Arginine and glutamine supplementation to culture media improves the performance ofvarious channel catfish immune cells. Fish and Shellfish Immunology. 32(5):762-8. PMID:22326940.

12. Mwangi, D. M., Y. Honda, S.P. Graham, R. Pelle, E. Taracha, G. H. Palmer, J. Gachanja, J.Nyanjui, J. Bray, W. C. Brown, and W. Mwangi. 2011. Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccineantigens induces CD4 and CD8 T cell IFN-γ responses but not CTL responses. Vet.Immunol Immunopathol. 140: 244-252. PMID: 21288576.

13. Chen, C. H., D. Abi-Ghanem, L. Njongmeta, J. Bray, W. Mwangi, S. Waghela, N. Ing, andL. R. Berghman. 2010. Production and characterization of monoclonal antibodies againstchicken CD40. Dev. Comp. Immunol., 34(11):1139-43 PMID: 20599554.

14. Flores-Mendoza, L., R.R. Sotelo-Mundo, H. Dawson, W. Mwangi, and J. Hernández. 2010.Characterization of porcine CD205. Dev. Comp. Immunol. 34(7):715-721.PMID: 20188754.

http://www.ncbi.nlm.nih.gov/pubmed?term=Small%20CM%5BAuthor%5D&cauthor=true&cauthor_uid=24505447

http://www.ncbi.nlm.nih.gov/pubmed?term=Ajithdoss%20DK%5BAuthor%5D&cauthor=true&cauthor_uid=24505447

http://www.ncbi.nlm.nih.gov/pubmed?term=Rodrigues%20Hoffmann%20A%5BAuthor%5D&cauthor=true&cauthor_uid=24505447

http://www.ncbi.nlm.nih.gov/pubmed?term=Esteve-Gassent%20MD%5BAuthor%5D&cauthor=true&cauthor_uid=24505447

http://www.ncbi.nlm.nih.gov/pubmed/22366632

http://www.ncbi.nlm.nih.gov/pubmed/20188754

D.W. Ng

CURRICULUM VITAE

I. PERSONAL INFORMATION

Name: Desmond W. Ng

Current Position: Assistant Professor in Strategic Management and Agribusiness

Management

349 B Blocker Building

Department of Agricultural Economics


College Station, TX, USA

Telephone: (979) 845-1192

Email: [email protected]

Date of

Appointment: June, 2004.

II. EDUCATION

Ph.D. University of Illinois at Urbana-Champaign, Urbana, Illinois

Fields: Strategic Management (Business Administration) and Agricultural

Economics

Degree Date: May 2001

Dissertation Title: “Application of Austrian Economic Theory and

Complexity Theory to the Institutional Evolution of Agricultural Markets”

M.Sc. McGill University, Montréal, Quebec, Canada

Major: Agricultural Economics and Management

Degree Date: April, 1997

Thesis Title: “Micro-Economic Evolution of Firm Behavior”

B.Sc. University of British Columbia, Vancouver, BC, Canada

Major: Agricultural Economics (Honors)

Degree Date: April, 1994

III. EXPERIENCE

A. Professional Experience

02/2010 Promotion to Associate with Tenure recommended by Dept. Head,

Dean of College of Agriculture and Life Science, and Dean of

Faculties. University president and chancellor’s decisions pending.

D.W. Ng

06/2004 – Present Assistant Professor, Department of Agricultural Economics,

Texas A&M University.

05/2009 – Present Visiting Assistant Professor at the Universidad del Valle de

Guatemala.

06/2004 – Present Full Member of Intercollegiate Faculty of Agribusiness (IFA),

Texas A&M University.

06/2006 – Present Full member of the Graduate Interdisciplinary Faculty of

Biotechnology in the PPIB (Professional Program in

Biotechnology), Texas A&M University.

06/2004 – 2008 Adjunct Professor in the Department of Rural Economy, University

of Alberta, Edmonton, Alberta, Canada.

10/2000 – 05/2004 Assistant Professor of Strategic Management and Agribusiness,

Department of Rural Economy, University of Alberta, Edmonton,

Alberta, Canada.

2002- 2003 Executive Committee Member for the Value Chain Action Team

of the Agriculture and Food Council of Alberta.

B. Accomplishments: Professional Honors and Awards

a. Best Paper nomination for 2008 8th International Chain Conference, Ede,

Netherlands for a paper titled: “Understanding the Market Dynamics of

Entrepreneurial Networks”.

b. Best paper award for the 2006 7th International Chain

Conference, Ede, Netherlands for a paper titled: ''The Paradox of

Embeddedness: Strong and Weak Tie Performance in the Biotechnology

Industry''.

c. Outstanding Research Paper Award for the 2005 International

Academy of Business Economics Annual Conference, Las Vegas for a

paper titled: “Strategic Change through a Competition of Realities”

d. Best paper for the 2004 Academy of Management Annual

Meetings, New Orleans for the Management and Organization Division

(MOC) and Nominee for the William H. Newman Award for a paper titled

“The Enactment of Competitive Markets and Organizational

Performance”.

C. Other Awards and Distinctions

a. Best Master’s thesis award, 1996, from the Canadian Agricultural

Economics Society: “The Micro-Economic Evolution of Firm Behaviors”.

b. Max Stern Recruitment Fellowship, McGill University, 1994-1996.

IV. PUBLICATIONS

A. Refereed Publications

Ng, D., and Siebert, J. 2010. “Toward Better Defining the Field of Agribusiness

Management” International Food and Agribusiness Management Review 12 (4):

1-20.

D.W. Ng

Ng, D, Westgren, R., and Sonka, S. 2009. “Competitive Blind Spots in an

Institutional Field” Strategic Management Journal 30 (4): 349-269. (Lead Article)

Ng, D. 2008. “Understanding the Market Dynamics of Entrepreneurial Networks”

Journal of Chain and Network Science 8 (2): 93-105.

Ng, D. 2008. “Structural Change in Food Supply Chains” International Food and

Agribusiness Management Review 11 (2): 17-48.

Ng, D. 2007. “A Modern Resource Based Approach to Unrelated Diversification”

Journal of Management Studies 44 (8): 1481-1502.

Ng, D., Unterschultz, J., and Laate, E. 2006. “The Performance of Relational Ties:

A Functional Approach in the Biotechnology Industry” Journal on Chain and

Network Science 6 (1): 9-21.

Ng, D. 2005. “Strategic Change through a Competition of Realities” Journal of

International Business Strategy 1 (1):1-10.

Ng, D. 2005. “Strategic Entrepreneurship: An Austrian Economic Approach to

Competitive Strategy” Journal of International Business Strategy 1 (1):75-84.

Getu, H., Jeffrey, S., Goddard, E., and Ng, D. 2005. “Regulatory Environment,

Co-operative Structure and Agency Costs for Co-operative Agribusiness Firms in

Canada: Comparative Case Studies” Journal of Food Distribution Research 36

(2): 39-49.

Ng, D. 2005. “The Discovery of and Coordination of Resource Complements in a

Dispersed Knowledge Society” International Journal of Human Resources

Development and Management 5 (2): 142-163.

Ng, D. 2004. “The Social Dynamics of Diverse and Closed Networks” Human

Systems Management 23: 111-122.

Hailu, G., Jeffrey S., Goddard, E., and Ng, D. 2004. “Incentive Incompatibility in

Co-operative Agribusiness Firms in Canada: Does Supply Management Matter?"

Journal of Food Distribution Research 35 (1): 110-111.

Ng, D., Sonka, S., and Westgren, R. 2003. “Co-evolutionary Processes in Supply

Chain Networks” Journal on Chain and Network Science 3 (1): 45-58.

Ng, D. 2003.”The Social Structure of Organizational Change and Performance”

Emergence: a Journal of Complex Issues in Organization and Management 5 (1):

ZIVKO L. NIKOLOV Dow Professor

EDUCATION: Dipl. Eng. Food Engineering University of Novi Sad, Serbia 1977 M.S. Chemical Engineering Iowa State University 1983 Ph.D. Chemical Engineering Iowa State University 1986

TEXAS A&M UNIVERSITY EMPLOYMENT: Dow Professor, Biological and Agricultural Engineering, 2002-present

OTHER PROFESSIONAL EMPLOYMENT: Vice President 2001 - 2002 ProdiGene Inc., College Station, TX Director 1999 - 2001 ProdiGene Inc., College Station, TX Professor 1998 - 1999 Food Sci. (75%) and Ag & Biosystems Eng. (25%)

Iowa State University, Ames, IA Assoc. Professor 1993 - 1998 Food Sci. (75%) and Ag & Biosystems Eng. (25%)

Iowa State University, Ames, IA Assist. Professor 1987 - 1993 Food Sci. & Human Nutr. Iowa State University, Ames, IA Senior Scientist 1986 - 1987 Michigan Biotechnology Institute, Lansing, MI

PROFESSIONAL REGISTRATION Registered Professional Engineer, State of Texas, No. 95216

CONSULTING and PATENTS (last 5 years)

Pat. Application 12/117621, November 2009. Process for improving products of dry milling. Pat Application 2009/050905, July 2009, Transformation of glycerol and cellulosic materials into high energy fuels. Philip Morris International Inc., Switzerland, Process cost analysis of antibody production from

transgenic tobacco, 2010 -2011. Syngenta Biotechnology Inc., Evaluation of process options for extraction and recovery of cellulases

expressed in transgenic plants, 2010. ERA Biotech, Barcelona, Spain, Process design and simulation for producing therapeutics in transgenic tobacco, 2005-2010

PRINCIPAL PUBLICATIONS (last 5 years) Munjal, N., Garzon-Sanabria, A. J., Quinones, K., Gregory, J., Nikolov, Z. L., 2014. Light-induced

production of an antibody fragment and malaria vaccine antigen from Chlamydomonas reinhardtii. Processes 2: 625-638.

Hood, C. N, Hood, K. R. , Woodard, S. L., Deviah, S. P., Jeoh, T., Wilken, L. R. , Nikolov, Z. L., Egelkrout, E., Howard, J .A., Hood, E, E. 2014. Purification and characterization of recombinant Cel7A from maize seed. Appl. Biochem. Biotechnol. 174: 2864-2874.

Garzon-Sanabria, A. J., Ramirez-Caballero, S.S., Moss, F., Nikolov, Z. L., 2013. Effect of algogenic organic matter (AOM) and sodium chloride on Nannochloropsis salina flocculation efficiency, Bioresource Technology, 143: 231-237.

Barros G.O.F, Ballen, M.A.T., Woodard S. L., Wilken, L. R., White, S. G., Damaj, M. B., Mirkov, T. E., and Nikolov Z. L. 2013. Recovery of bovine lysozyme from transgenic sugarcane stalks.Bioprocess Biosystems. Eng. 36: 1407-1416.

Engelkrout, E., McGaughey, K., Keener, T., Ferleman, A., Woodard, S., Devaiah, S. Nikolov, Z.L, Hood. E. and Howard, J. 2013. Enhanced Expression Levels of Cellulase Enzymes Using Multiple Transcription Units. Bioenerg. Res. 6: 699-710.

Wilken, L.R. and Z.L. Nikolov. 2012. Downstream processing of transgenic plant systems: Protein recovery and purification strategies. In: Ma, S. and A. Wang. (eds). Molecular Farming in Plants: Recent Advances and Future Prospects. Springer, New York. p. 217-57.

Garzon-Sanabria A. J, Davis, R., Nikolov, Z. L. 2012. Harvesting Nannochloris oculata by inorganic flocculation. Bioresource Technol., 118: 418-424.

Wilken, L. R. and Z. L. Nikolov. 2012. Recovery and purification of plant-made foreign proteins. Biotechnol. Advances 30: 419-43.

Garzon-Sanabria A. J, Davis, R., Nikolov, Z. L. 2012. Harvesting Nannochloris oculata by inorganic flocculation. Bioresource Technol., 118: 418-424.

Barros G.O.F, Woodard S.L., Nikolov Z. L. 2011. Phenolics removal from transgenic Lemna minor extracts expressing mAb and impact on mAb production cost. Biotechnol. Progr. 27: 410-418.

Wilken, L.R. and Z.L. Nikolov. 2011. Process evaluation and economic analyses of recombinant human lysozyme and hen egg-white lysozyme purifications. Biotechnol. Progr. 27: 733-743.

Howard, J. A., Nikolov, Z.L, Hood, E. E. Enzyme production systems for biomass conversion in Plant Biomass Conversion, (E. E. Hood, P. Nelson, and R. Powel, eds.) Wiley, 2011, pp. 219-246.

Wilken, L.R. and Nikolov, Z. L. 2010. Evaluation of Alternatives for Human Lysozyme Purification from Transgenic Rice: Impact of Phytic Acid and Buffer. Biotechnol. Prog. 26: 1303-1311.

Woodard, S.L., Wilken, L.R., Barros, G.O.F., White, S.G., & Nikolov, Z. L. 2009. Evaluation of monoclonal antibody and phenolic extraction from transgenic Lemna for purification process Development. Biotechnol. Bioeng.104: 562-571.

Nikolov, Z. L. Regan, J. T., Dickey. L. F. and Woodard, S. L. Purification of Antibodies from Transgenic Plants in Process Scale Purification of Antibodies (Uwe Gottschalk, ed.), Wiley, 2009, pp. 387-406.

SCIENTIFIC AND PROFESSIONAL SOCIETIES OF WHICH MEMBER: American Society of Agricultural Engineers (ASABE) Institute for Biological Engineering (IBE) American Chemical Society (ACS) International Society for Pharmaceutical Engineering (ISPE)

HONORS AND AWARDS:

Scientific Advisory Board, Infinite Enzymes, 2007 – present Scientific Advisory Board, ERA Biotech, Spain, 2006-2010 Who’s Who in Science and Engineering BAEN Research Award 2010 ADM Award for Best Publication in Engineering &Technology, American Oil Chemists Society, 1996 Visiting Professor, School of Chemical Engineering, State University of Campinas, Brazil, 1997 and 2005. Academic Research Fellow, Kraft Foods, Inc., 1995 Visiting Professor, Department of Chemical Engineering, Federal University of Rio Grande do Sul, Brazil, 1992.

INSTITUTIONAL AND PROFESSIONAL SERVICE (5 yrs) Editorial Board Member, Journal of Biotechnology and Bioengineering, 2014-present

Advisory Board, The National Center for Therapeutic Manufacturing, Texas A&M, 2012 - present NSF/SBIR Panel, Biomedical Devices, 2014 Scientific Board Member of the 6th Central European Congress on Food, Serbia 2012 NSF-CBET Panel, Metabolic Engineering and Biofuels, 2010

Editorial Board Member, Brazilian Journal of Chemical Engineering 2003-2008 Editorial Board Member, Journal of Biological Engineering 2007 – present Editorial Board Member: Acta Periodica Technologica, Serbia, 2003 – present

Principal Investigator PARK, William D.




NAME Park, William D.


eRA COMMONS USER NAME



University of South Carolina B.Sc. 1973 Chemistry University of University of Florida Ph.D. 1977 Biochemistry University of Minnesota Postdoc. 1978-1980 Genetics and Cell Biology

A. Positions and Honors.Positions and Employment1980 - 1983 Assistant Professor, Horticulture, Purdue University 1984 - 1990 Associate Professor, Biochemistry and Biophysics, TAMU 1991- Present Professor, Biochemistry and Biophysics, TAMU

Honors 2014: Invited to participate in the symposium “Dietary fiber: Optimizing accuracy of data for Labeling,

Databases and Research” to be held at the Institute for Food Technologist annual meeting in June 2014.

2012: Our work on deficiencies in the CODEX compliant total dietary fiber assay AOAC 2009.01/AACCI 3245.01 was cited by the originator of the assay, Barry McCleary, in a formal request to both AOAC and AACCI to revise the official assay protocols for dietary fiber that are used when making nutrient composition claims on food products.

2011: Based on the success of our long term collaboration, MARS Inc. donated an additional $45,000 to upgrade starch analytical capabilities of the Department of Biochemistry and Biophysics.

2010: Faculty Recognition Award from the Biochemistry Graduate Association. 2010: Based on the success of our long term collaboration, MARS Inc. donated $94,000 to upgrade

starch analytical capability of the Department of Biochemistry and Biophysics. 2009: Our lab was officially recognized as a key component of the MARS Global Food Platform. 2007: MARS Inc. recognized our “outstanding research and significant contributions on rice

knowledge”. This award was presented in person jointly by the Vice President of Research and Development for MARS FOOD USA, and his counterparts from Europe and Australia.

2007: Faculty Recognition Award from the Biochemistry Graduate Association 2007: Invited to speak at MARS’ Science Advisory Council Meeting in Amsterdam and to attend the

Executive Session to set directions for the use of molecular methods to enhance nutrition in MARS human and pet food programs

2006. Invited to speak at MARS’ Plant Breeding Multidisciplinary Research Unit meeting at MARS corporate headquarters and to attend the “closed” Executive Session to set directions for the MARS’ cocoa program

Principal Investigator PARK, William D.


B. Selected peer-reviewed publications (in chronological order).

Dobo M, N Ayres, G Walker, WD Park (2010) Polymorphism in the GBSS Gene Affects AmyloseContent in US and European Rice Germplasm. J Cereal Science 52: 450-456

Vitalini MW, RM de Paula, WD Park, D Bell-Pedersen (2006) The rhythms of life: Circadian outputpathways in Neurospora. J. Biological Rhythms 21: 434-444.

Fjellstrom, R, CA Conaway-Bormans, AM McClung, W Park (2004) Development of DNA MarkersSuitable for Marker Assisted Selection of Three Pi- Genes Conferring Resistance to MultiplePyricularia grisea pathotypes. Crop Science. 44: 1790-179,

McClung AM, CJ Bergman, RG Fjellstrom, CA Bormans, WD Park, MA Marchetti (2003) Registrationof Bolivar Rice. Crop Science 44: 353-354,

McClung AM, RG Fjellstrom, CJ Bergman, CA Bormans, WD Park, MA Marchetti (2003) Registrationof Saber Rice. Crop Science 44: 248-249.

Larkin PD, WD Park (2003) Association of waxy gene single nucleotide polymorphisms with starchcharacteristics in rice (Oryza sativa L.) Molec. Breeding 12: 335-339.

Bormans C, A McClung, A Marchetti, C Johnson, W Park (2003) Molecular markers linked to the blastresistance gene Pi-z in rice for use in marker-assisted selection. Theor. Appl. Genet. 107: 1014-1020

Larkin, PD, MA McClung, NM Ayres, WD Park (2003) The effect of the Wx locus (Granule BoundStarch Synthase) on pasting curve characteristics in specialty rice. Euphytica 131: 243-253

Curriculum Vitae

C. O. Patterson

Professor Emeritus of Biology Professor Emeritus of Biotechnology, Professor Emeritus of Molecular & Environmental Plant Sciences

Department of Biology, Texas A&M University College Station, Texas 77843-3258

phone (979) 845-2187 e-mail: [email protected] FAX: (979) 845-2891 EDUCATION: Postdoctorate Indiana University at Bloomington (1972-77), Microbiology Ph.D. University of Texas at Austin (1971), Zoology B.A. University of Texas at Austin (1964), Honors ACADEMIC EXPERIENCE: 2011 - present Professor Emeritus, Department of Biology, Texas A&M University 2006 - present Professor, Department of Biology, Texas A&M University 1984 - 2006 Associate Professor, Department of Biology, Texas A&M University. 1983 - 1984 Associate Professor, Department of Biology, Texas A&M University. Director of

Freshman Biology Programs 1980 - 1983 Assistant Professor, Department of Biology, Texas A&M University. Director of

Freshman Biology Programs. 1977 - 1980 Assistant Professor, Division of Biological Sciences, University of Missouri.

Director of Introductory Biology 1975 - 1977 Research Associate (Post-Doctoral), Department of Microbiology, Indiana

University 1972 - 1975 Visiting Assistant Professor, Division of Biological Sciences, Indiana University 1971 - 1972 Instructor, Department of Zoology, University of Texas. 1970 - 1971 Teaching Assistant, Department of Zoology, University of Texas 1967 - 1970 National Science Foundation Graduate Fellow, Dept of Zoology, Univ of Texas 1966 - 1967 Teaching Assistant, Department of Zoology, University of Texas. AREAS OF EXPERTISE AND RESEARCH EMPHASIS: Physiology and systems biology of photosynthetic microbes, including algae and cyanobacteria, photosynthetic metabolism, nutrient uptake and utilization, techniques of mass culture and cultivation. SOCIETY MEMBERSHIPS: Phi Beta Kappa, Sigma Xi, American Society of Plant Biologists, Phycological Society of America,

American Association for the Advancement of Science, National Association of Biology Teachers, Texas Academy of Science

SELECTED RECENT PUBLICATIONS AND PRESENTATIONS: C.O.Patterson: Harmful Algal Blooms: Toxic Algae and Algal Toxins. in Encyclopedia of Aquaculture, Robert Stickney, ed., John Wiley & Sons publishers, New York, pp17-25, (2000). R.D. VanPutte and C.O. Patterson: Micro-algal Plasma Membranes Purified by Aqueous Two-Phase Partitioning. Transactions of the Illinois State Academy of Science 96, 71-86 (2003). Wm. Bond, B. Briggs, F. Brown, M. Case, N. Ganguly, H.A.E. Howell, L. Kirby, C.O.Patterson, J. Schutter: The AP Vertical Teams Guide for Science. The College Board, New York, New York, 2004, 224 pages. (Authors are listed alphabetically.)


C.O.Patterson et al.: Texas College Readiness Standards (Adopted by Texas Higher Education Coordinating Board, January 24, 2008) Complete list of authors at end of document. pdf version posted at <http://www.thecb.state.tx.us/collegereadiness/TCRS.cfm> J.J. Brand, D.W. Krogmann, and C.O. Patterson: Jack Edgar Myers (1913 - 2006), an algal physiologist par excellence. Photosynthesis Research 96: 9-14 (2008) C.O.Patterson: "Development and Implementation of the Texas College Readiness Standards" keynote address at Austin Community College's Conference on College Readiness Standards. Austin, Texas, 1 August 2008. C.O.Patterson: "How to Do Inquiry-Based Exercises and Activities in the Large Lecture Classroom." TAMU Center for Teaching Excellence. 15 October 2008 C.O.Patterson & Wendy Keeney-Kennicut: Writing in the Science Curriculum: Using the Calibrated Peer Review System for Writing Assignments in Science Classes. 2-day workshop for faculty at University of Kentucky (Lexington), 20-21 February 2009 C.O.Patterson: Overview of College Readiness Standards in Science (keynote address) at College & Career Readiness Initiative Faculty Collaborative Science Symposium. sponsored by Texas Higher Education Coordinating Board, held at Texas A&M University - Corpus Christi, 28 February 2009 C.O.Patterson & Linda Gann: College Readiness Standards in Science & Math: Implementation & Assessment. one-day workshop for science & math faculty from Texas State University (San Marcos) and from Alamo Community College District (Bexar County) part of the "Puentes" project of TSU. 3 April 2009 C.O.Patterson: Development & Use of College Readiness Standards in Science (keynote address) at Community College Symposium for Mathematics and Science Faculty. sponsored by Texas Higher Education Coordinating Board, held at Austin Community College, 24-25 September 2009 C.O.Patterson: College Readiness Activities - Development of Pilot Activities, Kick-off meeting, sponsored by Texas Higher Education Coordinating Board, held in Austin, 13 October, 2009. I prepared and led the working group (about 40 educators) through an example exercise to show what a "College-Readiness Activity" would look like. Timothy P. Scott, C.O.Patterson, and Adrienne Bentz: Incorporating College and Career Readiness Standards into Capstone Science and Mathematics Methods Courses. poster presentation at CCRI Symposium sponsored by Texas Higher Education Coordinating Board and Texas State University, San Antonio 26 February 2010 C.O.Patterson, T.L. Weiss, Timothy Devarenne: Environmental Impacts of Algal Biofuels. Seminar for members of National Wildlife Federation Biofuels Review Team. TAMU, 17 August 2010. RECENT GRANTS & FUNDING RECEIVED: “Texas Collaborative for Excellence in Teacher Preparation (TxCETP)” NSF, $5,207,500. 2000-2006.

Co-PIs are Mauro Castro (TAMU-Kingsville), Pam Littleton (TAMU-Tarleton), and Kit Price (TAMU-Corpus Christi). I served on the steering committee for the project, and was team leader for the College Station campus.

“Writing for Assessment and Learning in Science (WALS) -- Application of the Calibrated Peer Review System for Biology, Mathematics, and Physics.” NSF-DUE, $481,850, 2003-2007. Dr. Nancy Simpson (Math), Dr. Michael Stecher (Math), Dr. Lewis Ford (Physics), and I are Co-PIs on this project. "Development of College Readiness Standards for Texas High School Curriculum." Texas Higher Education Coordinating Board - Texas Education Agency. $25,000, 2007. "Bioreactor Design and Testing for Biofuel Production by Photosynthetic Microbes" Harizan Venture Capital Investments. $35,000, 2006 - present

http://biochemistry.tamu.edu/faculty/devarenne-timothycontrol-of-plant-programmed-cell-death-during-plant-pathogen-interactions-algal-biofuels/


Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME

Suresh D. Pillai

POSITION TITLE

Director and Professor eRA COMMONS USER NAME



YEAR(s) FIELD OF STUDY

Loyola College, Madras B.Sc. 1983 Botany University of Madras M.Sc. 1985 Industrial Microbiology University of Arizona Ph.D. 1989 Microbiology &

Immunology

A. Personal StatementMy research program is focused on the molecular ecology of microbial pathogens in natural and man-madeecosystems. We are specifically focused on those pathogens that are of relevance to the human GI tract and aretransmitted by the food and water routes. As part of these activities, we have been focused on improving ourunderstanding of cell-cell signaling, microbial inactivation processes, microbial detection and characterizationtechnologies My research has impacted the field of bioaerosols (sewage sludge land application programs), microbialcell-cell signaling on foods, and how food irradiation technologies can address emerging pathogen issues. My lab’scurrent focus is on developing novel therapeutic products that can be used as prophylactics against food and water-borne infectious diseases, modulating gut colonization in ovo or post therapeutic perturbations. My lab has stronginteractions with the International Atomic Energy Agency (IAEA) in the use of electron beam technologies fordeveloping novel therapeutics, environmental remediation, global food safety and global food security.

B. Positions and HonorsPositions and Employment2004-present Professor and Texas A&M AgriLife Faculty Fellow, Food Safety & Environmental Microbiology

Program, Poultry Science & Nutrition & Food Science Departments, Texas A&M University 2003-present Director, National Center for Electron Beam Research, Texas A&M University 2003-2010 Chair, Graduate Faculty of Biotechnology, Texas A&M University 2000-2005 Associate Director, Institute of Food Science & Engineering, Texas A&M University 2000-2004 Associate Professor & TAES Faculty Fellow -Food Safety and Environmental Microbiology

Program, Poultry Science Dept. Texas A&M University 2000-present Member of TAMU Graduate Faculties: Poultry Science, Food Science & Technology,

Biotechnology, Veterinary Pathobiology, Toxicology, Soil & Crop Sciences, and Water Program 1998-1999 Associate Professor, Texas A&M Univ. Research Center, El Paso, and Soil and Crop Sciences,

Texas A&M University, College Station, Texas. 1992- 1998 Assistant Professor, Texas A&M Univ. Research Center, El Paso, and Soil and Crop Sciences,

Texas A&M University, College Station, Texas. 1991-1992 Research Scientist, Accelerated Products Develop Program, Naval Medical Research Inst.,

Bethesda, MD.

Other Appointments 2013-present FDA Science Advisory Board, National Center for Toxicological Research, Jefferson, AK 2006-2011 Member, External Advisory Board, Dept. of Homeland Security, Center of Advancing Microbial

Risk Assessment, Michigan State University. 2006-2013 Member, US Government Accountability Office (GAO) expert panel on risks posed by BSL-

3/BSL-4 laboratories in the United States

2013 Member, Microbiology Review Team, FDA-National Center for Toxicological Research 1991-1992 Research Assistant Professor of Medicine, Department of Medicine, Uniformed Services University

of the Health Sciences, National Naval Medical Center, Bethesda, MD.

Memberships and Honors 2011 Elected Fellow, International Forum on Industrial Bioprocesses 2010-present Member, Committee on Environmental Microbiology, American Society for Microbiology 2010-present Member, Science Advisory Board, BCR Environmental, Inc. Florida 2008-2011 Member, International Review Committee, Obihiro University of Agriculture and Veterinary

Medicine, Obihiro, Japan 2008 President’s Travel Fund Award- Society for Applied Microbiology (SFAM) 2007-2008 Member International Advisory Committee, Kalasalingam University, India 2007-2010 Institute of Food Technologists (IFT)- Distinguished Lecturer 2007 State of Texas Environmental Excellence Award (Team-member) 2004-2010 Elected Member, Council of Principal Investigators, Texas A&M University

C. Selected peer-reviewed publications1. Ágoston, R., K.A. Soni, P. Jesudhasan, W.Russell, C.M. Farkas, and S.D. Pillai (2009) Differential Expression

of Proteins in Listeria monocytogenes under Thermo Tolerance-Inducing, Heat Shock, and Prolonged HeatShock Conditions. Foodborne Pathogens and Disease 6: 1133-1140

2. Vikram, A., Jesudhasan, P. R., Pillai, S. D., & Patil, B. S. (2012). Isolimonic acid interferes with Escherichia coliO157:H7 biofilm and TTSS in QseBC and QseA dependent fashion. BMC Microbiology, 261-263

3. Widmer, K. W., Jesudhasan, P., & Pillai, S. D. (2012). Fatty acid modulation of autoinducer (AI-2) influencedgrowth and macrophage invasion by salmonella typhimurium. Foodborne Pathogens Disease, 9(3), 211-217.

4. Sooresh, A., Zeng, Z., Chandrasekharan, J., Pillai, S. D., & Sayes, C. M. (2012). A physiologically relevantapproach to characterize the microbial response to colloidal particles in food matrices within a simulatedgastrointestinal tract. Food and Chemical Toxicology, 50(9), 2971-2977.

5. Bordin, A.I., Suchodolski, J.S., Markel, M.E., Weaver, K.B., Steiner, J.M., Dowd, S.E., Pillai, S., and Cohen,N.D. (2013) Effects of administration of live or inactivated virulent Rhodococccus equi and age on the fecalmicrobiome of neonatal foals. PlosOne 8: e66640

6. Praveen, C., Dancho, B.A., Kingsley, D.H., Calci, K.R., Meade, G.K., Mena, K.D. and Pillai, S.D. (2013).Susceptibility of Murine Norovirus and Hepatitis A Virus to Electron Beam Irradiation in Oysters and Quantifyingthe Reduction in Potential Infection Risks. Applied and Environmental Microbiology 79: 3796-3801

7. Garcia, T.P., Muller, S., Carroll, R.J., Dunn, T.N., Thomas, A.P., Adams, S.H., Pillai, S.D. and Walzem, R.L.(2013). Structured variable selection with q-values. Biostatistics DOI:10.1093/biostatistics/kxt012

8. Bordin, A.L., S.D. Pillai, C. Brake, K.B. Bagley, J.R. Bourquin, M. Coleman, F.N. Oliviera, W. Mwangi,D.N.McMurray, C.C. Love, M.J.B. Felippe, and N.D. Cohen. (2014) Immunogenicity of an electron beaminactivated Rhodococcus equi vaccine in neonatal foals. PlosOne. DOI: 10.1371/journal.pone.0105367

D. On-Going Research SupportState of Texas Pillai (PI) 2/2014-1/2016This project is focused on exploiting eBeam technologies to inactivate infectious pathogens and organiccontaminants in wastewater effluents in water reuse facilities to enhance water availability in the State of Texas.

United States Dept. of Agriculture Pillai (PI) 10/2013-9/2016 This project is focused on understanding the metabolic activity and metabolome of key enteric pathogens after exposure to variety of chemical and non-thermal stressors. Aim is to exploit this understanding to develop enhanced vaccines

Corporate Sponsor Staack (PI) 9/2014-3/2015 This project is focused on exploiting electron beam technology (eBeam) technology for environmental remediation

Name: Keerti S. Rathore Title: Professor Address: Institute for Plant Genomics and Biotechnology and Dept. of Soil & Crop Sciences, Texas A&M University, College Station, TX 77843-2123 Telephone: (979) 862-4795 Fax: (979) 862-3414 E-mail: [email protected] Education/Training: Ph.D. (1981) Imperial College, University of London, U.K. (Plant Physiol.) M.Sc. (1976) Gujarat University, India (Plant Sciences) B.Sc. (1973) Rajasthan University, India (Zoology, Botany, Chemistry) Positions and Employment: 12- Professor and Director, Laboratory for Crop Transformation, Institute for Plant

Genomics & Biotechnology and Dept. of Soil & Crop Sciences, Texas A&M University, College Station, TX. A member of the Faculty of Molecular & Environmental Plant Sciences.

03-12 Associate Professor and Director, Laboratory for Crop Transformation, Institute for Plant Genomics & Biotechnology and Dept. of Soil & Crop Sciences, Texas A&M University, College Station, TX. A member of the Faculty of Molecular & Environmental Plant Sciences.

97-03 Assistant Professor and Director, Laboratory for Crop Transformation, Institute for Plant Genomics & Biotechnology and Dept. of Soil & Crop Sciences, Texas A&M University, College Station, TX. A member of the Faculty of MEPS.

95-97 Asst. Research Scientist and Director, Laboratory for Crop Transformation, Crop Biotechnology Center, Texas A&M University, College Station, TX.

91-95 Research Scientist, Dept. of Botany and Plant Pathology, Purdue University, W. Lafayette, IN.

85-90 Postdoctoral Research Associate, Dept. of Biological Sciences, Purdue University, W. Lafayette, IN.

82-84 Postdoctoral Research Associate, Dept. of Pure & Applied Biology, Imperial College, London, U.K.

Professional Society Membership:

American Association for the Advancement of Science

American Society of Plant Physiologists Awards and Honors:

J. J. Chinoy medal by Gujarat University (1976).

2011 Cotton Genetics Research Award Publications: 1. JOSHI, A.K., SHARMA, N.S., RATHORE, K.S., VAISHNAV, P.P. & SINGH, Y.D. 1980 Auxin oxidizing systems and ascorbic acid turnover in relation to physiology of dwarfism in Sorghum

bicolor (L.) Moench. Biochem. Physiol. Pflanzen 175: 208-215. 2. RATHORE, K.S. & GOLDSWORTHY, A. 1985 Electrical control of growth in plant tissue cultures. Bio/technology 3: 253-254. 3. RATHORE, K.S. & GOLDSWORTHY, A. 1985

Electrical control of shoot regeneration in plant tissue cultures. Bio/technology 3: 1107-1109. 4. GOLDSWORTHY, A. & RATHORE, K.S. 1985


The electrical control of growth in plant tissue cultures: the polar transport of auxin. J. Exp. Bot. 36: 1134-1141.

5. RATHORE, K.S., HODGES, T.K. & ROBINSON, K.R. 1988 Ionic basis of currents in somatic embryos of Daucus carota. Planta 175: 280-289. 6. RATHORE, K.S., HODGES, T.K. & ROBINSON, K.R. 1988

A refined technique to apply electrical currents to callus cultures. Plant Physiol. 88: 515-517. 7. RATHORE, K.S. & ROBINSON, K.R. 1989

Ionic currents around developing embryos of higher plants in culture. Biol. Bull. 176(S): 46-48. 8.

‡WANG, C., RATHORE, K.S. & ROBINSON, K.R. 1989

The responses of pollen to applied electrical fields. Dev. Biol. 136: 405-410. 9. RATHORE, K.S., HOTARY, K.B. & ROBINSON, K.R. 1990 A two-dimensional vibrating probe study of currents around lateral roots of Raphanus sativus

developing in culture. Plant Physiol. 92: 543-546. 10. **RATHORE, K.S., CORK, R.J. & ROBINSON, K.R. 1991

A cytoplasmic gradient of Ca2+ is correlated with the growth of lily pollen tubes. Dev. Biol. 148: 612-619. 11. RATHORE, K.S., CHOWDHURY, V.K. & HODGES, T.K. 1993

Use of bar as a selectable marker gene and for the production of herbicide-resistant rice plants. Plant Mol. Biol. 21: 871-884.

12. RAO, K. V., RATHORE, K. S. & HODGES, T. K. 1995 Physical, chemical and physiological parameters for electroporation-mediated gene delivery into rice

protoplasts. Transgenic Research 4: 361-368. 13. **RAO, K. V., RATHORE, K. S., HODGES, T. K., FU, X., STOGER, E., SUDHAKAR, D., WILLIAMS, S.,

CHRISTOU, P., BHARATHI, M., BOWN, D. P., POWELL, K.S., SPENCE, J., GATEHOUSE, A.M.R. & GATEHOUSE, J. A. 1998 Expression of snowdrop lectin (GNA) in transgenic rice plants confers resistance to rice brown planthopper. Plant Journal 15: 469-477.

14. SUNILKUMAR, G. & *RATHORE, K. S. 2001 Transgenic cotton: factors influencing Agrobacterium-mediated transformation and regeneration. Molecular Breeding 8: 37 - 52.

15. EMANI, C., SUNILKUMAR, G. & *RATHORE, K. S. 2002 Transgene silencing and reactivation in sorghum. Plant Science 162:181-192.

16. SUNILKUMAR, G., CONNELL J. P., SMITH C. W., REDDY A. S. & *RATHORE K. S. 2002 Isolation and functional characterization of alpha-globulin promoter from cotton in transgenic cotton, Arabidopsis and tobacco. Transgenic Research 11: 347-359.

17. SUNILKUMAR, G., MOHR, L., LOPATA-FINCH, E., EMANI, C. & *RATHORE, K. S. 2002 Developmental and tissue-specific expression of CaMV 35S promoter in cotton as revealed by GFP. Plant Molecular Biology 50: 463-474.

18. EMANI, C., GARCIA, J. M., LOPATA-FINCH, E., POZO, M., ‡URIBE, P., KIM, D-J., SUNILKUMAR,

G., COOK, D. R., KENERLEY, C. M. & *RATHORE, K. S. 2003 Enhanced fungal resistance in transgenic cotton expressing an endochitinase gene from Trichoderma virens. Plant Biotechnology Journal 1: 321-336.

19. ‡JAY, C. M., BHASKARAN, S., RATHORE, K. S. & WAGHELA, S. D. 2004 Enterotoxigenic K99

+ Escherichia coli attachment to host cell receptors inhibited by recombinant pili

protein. Veterinary Microbiology 101: 153-160. 20. SUNILKUMAR, G., CAMPBELL, L. M.,

‡MONJUR, H., CONNELL, J. P., HERNANDEZ, E., REDDY,

A. S., SMITH, C. W. & *RATHORE, K. S. 2005 A comprehensive study of the use of a homologous promoter in antisense cotton lines exhibiting a high seed oleic acid phenotype. Plant Biotechnology Journal, 3: 319-330.

21. ‡BURRELL, A. M., LINEBERGER, R. D., RATHORE K. S. & BYRNE, D. H. (2006) Genetic variation in somatic embryogenesis of rose. Hortscience 41: 1165-1168.

22. SUNILKUMAR, G., CAMPBELL, L. M., PUCKHABER, L., STIPANOVIC, R.D. & *RATHORE K. S. (2006) Engineering cottonseed for use in human nutrition by tissue-specific reduction of toxic gossypol. Proceedings of the National Academy of Sciences, USA 103: 18054-18059 (Cover Page Article).

23. REN, S, MANDADI, K. K., BOEDEKER, A. L., RATHORE K. S. & MCKNIGHT, T. D. (2007) Regulation of telomerase in Arabidopsis by BT2, an apparent target of TELOMERASE ACTIVATOR1. Plant Cell 19: 23-31.

24. PARKHI, V., KUMAR, V., SUNILKUMAR, G., CAMPBELL, L. M., SINGH, N. K. & *RATHORE K. S. (2009) Expression of apoplastically secreted tobacco osmotin in cotton confers drought tolerance. Molecular Breeding 23: 625-639.

25. SUNILKUMAR, G., WAGHELA, S. D., CAMPBELL, L. M. & *RATHORE K. S. (2009) Expression of anti-K99 scFv in transgenic rice tissues and its functional characterization. Transgenic Research 18: 347-360.

26. KUMAR, V., PARKHI, V., KENERLEY, C. & *RATHORE K. S. (2009) Defense-related gene expression and enzyme activities in transgenic cotton plants expressing an endochitinase gene from Trichoderma virens in response to interaction with Rhizoctonia solani. Planta 230: 277-291.

27. DAMAJ, M. B., KUMPATLA, S. P., EMANI, C., BEREMAND, P. D., REDDY, A. S., RATHORE, K. S., BUENROSTRO-NAVA, M. T., CURTIS, I. S., THOMAS, T. L. & MIRKOV, T. E. (2010) Sugarcane DIRIGENT and O-METHYLTRANSFERASE promoters confer stem-regulated gene expression in diverse monocots. Planta 231: 1439-1458.

28. PARKHI, V., KUMAR, V., CAMPBELL, L. M., BELL, A. A., SHAH, J. & *RATHORE K. S. (2010a) Resistance against various fungal pathogens and reniform nematode in transgenic cotton plants expressing Arabidopsis NPR1. Transgenic Research 19: 959-975.

29. PARKHI, V., KUMAR, V., CAMPBELL, L. M., BELL, A. A. & *RATHORE K. S. (2010b) Expression of Arabidopsis NPR1 in transgenic cotton confers resistance to non-defoliating isolates of Verticillium dahliae but not the defoliating isolates. Journal of Phytopathology 158: 822-825.

30. MURTHY, K.N.C., JAYAPRAKASHA, G. K., KUMAR, V., RATHORE, K. S. & PATIL, B.S. (2011) Citrus Limonin and its Glucoside Inhibit Colon Adenocarcinoma Cell Proliferation through Apoptosis. J. Agricultural & Food Chem. 59:2314-2323.

31. KUMAR, V., CAMPBELL, L. M. & *RATHORE K. S. (2011) Rapid recovery- and characterization of transformants following Agrobacterium-mediated T-DNA transfer to sorghum. Plant Cell Tiss. Organ Cult. 104: 137-146.

32. *RATHORE, K. S., SUNDARAM, S., SUNILKUMAR, G., CAMPBELL, L. M., PUCKHABER, L., MARCELL, S., PALLE, S. R., STIPANOVIC, R. D. & WEDEGAERTNER, T.C. (2012) Ultra-low gossypol cottonseed: generational stability of the seed-specific, RNAi-mediated phenotype and resumption of terpenoid profile following seed germination. Plant Biotech J. 10: 174-183.

33. KUMAR, V., PARKHI, V., JOSHI, S., CHRISTENSEN, S., KOLOMIETS, M. & *RATHORE K. S. (2012) A novel, conditional, lesion mimic phenotype in cotton cotyledons due to the expression of an endochitinase gene from Trichoderma virens. Plant Science 183: 86-95.

34. KUMAR, V., JOSHI, S. G., BELL, A. A. & *RATHORE K. S. (2013) Enhanced resistance against Thielaviopsis basicola in transgenic cotton plants expressing Arabidopsis NPR1 gene. Transgenic Res. 22: 359-368.

35. PALLE, S. R., CAMPBELL, L. M., PANDEYA, D., PUCKHABER, L., TOLLACK, L. K., MARCELL, S., SUNDARAM, S., STIPANOVIC, R. D., HINZE, L., WEDEGAERTNER, T.C. & *RATHORE, K. S. (2013) RNAi-mediated Ultra-low Gossypol Cottonseed Trait: Performance of Transgenic Lines under Field Conditions. Plant Biotech J. 11: 296-304.

36. REN, Y., BANG, H., GOULD, J., RATHORE K. S., PATIL, B. S. & CROSBY, K. M. (2013) Shoot regeneration and ploidy variation in tissue culture of honeydew melon (Cucumis melo L. inodorus). In Vitro Cell Dev. Biol. – Plant 49: 223-229.

37. REN, Y., BANG, H., LEE, E. J., GOULD, J., RATHORE K. S., PATIL, B. S. & CROSBY, K. M. (2013) Levels of phytoene and b-carotene in transgenic honeydew melon (Cucumis melo L. inodorus). Plant Cell Tiss. Organ Cult. 113: 291-301.

38. GAO, S-J., DAMAJ, M. B., PARK, J. W., BUENROSTRO-NAVA, M. T., MOLINA, J., WANG, X., CIOMPERLIK, J. J., MANABAYEVA, S. A., ALVARARADO, V. Y., RATHORE K. S., SCHOLTHOF, H. B. & MIRKOV, T. E. (2013) Enhanced Transgene Expression in Sugarcane by Co-Expression of Virus-Encoded RNA Silencing Suppressors. PLoS One. 8: 1-13.

39. Urriola, J. & Rathore K. S. (2013) Temporal and spatial activities of a rice glutelin promoter in transgenic sorghum. Plant Cell Tiss Organ Cult. DOI 10.1007/s11240-013-0398-8.

David H. Russell, Ph.D. AB/MDS Sciex Professor of Mass Spectrometry

Department of Chemistry

Texas A&M University 3255 TAMU

College Station, TX 77843 Tel: 979-845-3345; Fax: 979-845-7561

Email: [email protected] http://www.chem.tamu.edu/rgroup/russell

Education and Training 1974 B.S. Chemistry University of Arkansas-Little Rock 1978 Ph.D. Chemistry University of Nebraska-Lincoln Research and Professional Experience Oct 2006 – Sep 2014 Head, Department of Chemistry, Texas A&M University 2013-present Associate Editor, Journal of the American Society for Mass Spectrometry 2002-present AB/MDS Sciex Professor of Mass Spectrometry 2001-present Co-Director, Center for Structural Biology 1994-present Director, Laboratory for Biological Mass Spectrometry, Texas A&M University 1989-present Professor, Department of Chemistry, Texas A&M University 1980-1989 Assistant and Associate Professor, Texas A&M University 1987-1990 Chairman, Analytical Chemistry Division, Texas A&M University 1978-1980 Research Scientist, Oak Ridge Nat’l Laboratory, Division of Analytical Chemistry Professional Awards and Honors 2013 Frank H. Field and Joe L. Franklin Award for Outstanding Achievement in Mass Spectrometry

(ACS national award; sponsored by The Waters Corp.) 2004 Distinguished Achievement Award for Research Fellow of the American Association for the Advancement of Science TL Minnesota Chromatography Forum, Special Recognition National Science Foundation/Am. Society of National Science Foundation, Two Year Extension for

Special Creativity Mass Spectrometry Foreign Travel Award Teaching Experience 35 years of teaching experience (since 1980) at TAMU Courses taught: CHEM 315 (Quantitative Analysis), CHEM 316 (Quantitative Analaysis), CHEM 317 (Quantitative Analysis), CHEM 318 (Quantitative Analysis Laboratory, CHEM 415 (Analytical Chemistry), CHEM 491 (Research), CHEM 601(Analytical Chemistry I), CHEM 602 (Analytical Chemistry II), CHEM 681 (Seminar), CHEM 689 (Special Topics in mass spectrometry), CHEM 689 (Spec Topics in bioanalytical separations and mass spectrometry (joint with Prof. G. Vigh).

Selected Publications:

1. Patrick, J. W.; Gamez, R. C., Russell, D. H. Elucidation of Conformer Preferences for a Hydrophobic Antimicrobial Peptide by Vesicle Capture-Freeze-Drying: A Preparatory Method Coupled to Ion Mobility-Mass Spectrometry. Anal. Chem. 2015, 87, 578-583.

2. Shi, L.; Holliday, A. E.; Shi, H.; Zhu, F.; Ewing, M. A.; Russell, D. H.; Clemmer, D. E.

Characterizing Intermediates Along the Transition from Polyproline I to Polyproline II Using Ion Mobility Spectrometry- Mass Spectrometry. J. Am. Chem. Soc. 2014, 136(36), 12702-12711.

3. Servage, K. A.; Silveira, J. A.; Fort, K. L.; Russell, D. H. Evolution of Hydrogen-Bond Networks in

Protonated Water Clusters H+(H2O)n (n = 1 to 120) Studied by Cryogenic Ion Mobility-Mass Spectrometry. J. Phys. Chem. Lett. 2014, 5(11), 1825-1830.

4. Fort, K. L.; Silveira, J. A.; Pierson, N. A.; Servage, K. A.; Clemmer, D. E.; Russell, D. H. From

Solution to the Gas Phase: Factors That Influence Kinetic Trapping of Substance P in the Gas Phase. J. Phys. Chem. B 2014, 118(49), 14336-14344.

5. Chen, S.-H.; Chen, L.; Russell, D. H. Metal-Induced Conformational Changes of Human

Metallothionein-2A: A Combined Theoretical and Experimental Study of Metal-Free and Partially Metalated Intermediates. J. Am. Chem. Soc. 2014, 136(26), 9499-9508.

6. Zinnel, N. F.; Russell, D. H. Size-to-Charge Dispersion of Collision-Induced Dissociation Product

Ions for Enhancement of Structural Information and Product Ion Identification. Anal. Chem. 2014, 86(10), 4791-4798.

7. Chen, L.; Chen, S.-H.; Russell, D. H. An Experimental Study of the Solvent-Dependent Self-

Assembly/Disassembly and Conformer Preferences of Gramicidin A. Anal. Chem. 2013, 85(16), 7826-7833.

8. Pierson, N. A.; Chen, L.; Russell, D. H.; Clemmer, D. E. Cis-Trans Isomerizations of Proline

Residues Are Key to Bradykinin Conformations. J. Am. Chem. Soc. 2013, 135(8), 3186-3192.

9. Chen, S.-H.; Russell, W. K.; Russell, D.H. Combining Chemical Labeling, Bottom-Up and Top-Down Ion-Mobility Mass Spectrometry To Identify Metal-Binding Sites of Partially Metalated Metallothionein. Anal. Chem. 2013, 85(6), 3229-3237.

10. Silveira, J. A.; Servage, K.A.; Gamage, C. M.; Russell, D. H. Cryogenic Ion Mobility-Mass

Spectrometry Captures Hydrated Ions Produced During Electrospray Ionization. J. Phys. Chem. A 2013, 117(5), 953-961.

11. Silveira, J. A.; Fort, K. L.; Kim, D.; Servage, K. A.; Pierson, N. A.; Clemmer, D. E.; Russell, D. H.

From Solution to the Gas Phase: Stepwise Dehydration and Kinetic Trapping of Substance P Reveals the Origin of Peptide Conformations. J. Am. Chem. Soc. 2013, 135(51), 19147-19153.

12. Bailey, A. O.; Panchenko, T.; Sathyan, K. M.; Petkowski, J. J.; Pai, P.-J.; Bai, D. L.; Russell, D.

H.; Macara, I. G.; Shabanowitz, J.; Hunt, D. F.; et al. Proc. Natl. Acad. Sci. USA 2013, 110(29), 11827-32.

13. Chen, L.; Gao, Y. Q.; Russell, D. H. How Alkali Metal Ion Binding Alters the Conformation

Preferences of Gramicidin A: A Molecular Dynamics and Ion Mobility Study. J. Phys. Chem. A 2012, 116(1), 689-696.

14. May, J. C.; Russell, D. H. A mass-selective variable-temperature drift tube ion mobility-mass

spectrometer for temperature dependent ion mobility studies. J. Am. Soc. Mass Spectrom. 2011, 22(7), 1134-1145.

15. Blase, R. C.; Silveira, J.A.; Gillig, K. J.; Gamage, C. M.; Russell, D. H. Increased ion transmission

in IMS: A high resolution, periodic-focusing DC ion guide ion mobility spectrometer. Int. J. Mass Spectrom. 2011, 301(1-3), 166-173.

16. Castellana, E. T.; Gamez, R.C.; Russell, D. H. Label-Free Biosensing with Lipid-Functionalized

Gold Nanorods. J. Am. Chem. Soc. 2011, 133(12), 4182-4185.

17. Chen, L.; Shao, Q.; Gao, Y.-Q.; Russell, D. H. Molecular Dynamics and Ion Mobility Spectrometry Study of Model β-Hairpin Peptide, Trpzip1. J. Phys. Chem. A 2011, 115(17), 4427-4435.

18. Pierson, N. A.; Chen, L.; Valentine, S. J.; Russell, D. H.; Clemmer, D. E. Number of Solution

States of Bradykinin from Ion Mobility and Mass Spectrometry Measurements. J. Am. Chem. Soc. 2011, 133(35), 13810-13813.

19. Fernandez-Lima, F. A.; Blase, R. C.; Russell, D. H. A study of ion-neutral collision cross-section

values for low charge states of peptides, proteins, and peptide/protein complexes. Int. J. Mass Spectrom. 2010, 298(1-3), 111-118.

20. Wu, Z.; Fernandez-Lima, F. A.; Russell, D. H. Amino Acid Influence on Copper Binding to

Peptides: Cysteine Versus Arginine. J. Am. Soc. Mass Spectrom. 2010, 21(4), 522-533.

21. McLean, J. R.; McLean, J. A.; Wu, Z.; Becker, C.; Perez, L. M.; Pace, C. N.; Scholtz, J. M.; Russell, D. H. Factors That Influence Helical Preferences for Singly Charged Gas-Phase Peptide Ions: The Effects of Multiple Potential Charge-Carrying Sites. J. Phys. Chem. B 2010, 114(2), 809-816.

22. Castellana, E. T.; Gamez, R. C.; Gomez, M. E.; Russell, D. H. Longitudinal Surface Plasmon

Resonance Based Gold Nanorod Biosensors for Mass Spectrometry. Langmuir 2010, 26(8), 6066-6070.

23. Predel, R.; Neupert, S.; Garczynski, S. F.; Crim, J. W.; Brown, M. R.; Russell, W. K.; Kahnt, J.;

Russell, D. H.; Nachman, R. J. Neuropeptidomics of the Mosquito Aedes aegypti. J. Proteome Res. 2010, 9(4), 2006-2015.

24. Sun, W.; May, J. C.; Gillig, K. J.; Russell, D. H. A dual time-of-flight apparatus for an ion mobility-

surface-induced dissociation-mass spectrometer for high- throughput peptide sequencing. Int. J. Mass Spectrom. 2009, 287(1-3), 39-45.

25. Huang, Y.; Marini, J. A.; McLean, J. A.; Tichy, S. E.; Russell, D. H. A mechanistic study of the H/D

exchange reactions of protonated arginine and arginine-containing di- and tripeptides. J. Am. Soc. Mass Spectrom. 2009, 20(11), 2049-2057.

26. Becker, C.; Fernandez-Lima, F. A.; Gillig, K. J.; Russell, W. K.; Cologna, S. M.; Russell, D. H. A

Novel Approach to Collision-Induced Dissociation (CID) for Ion Mobility-Mass Spectrometry Experiments. J. Am. Soc. Mass Spectrom. 2009, 20(6), 907-914.

James SacchettiniProfessor Wolfe-Welch Chair in Sciences Department of Biochemistry and Biophysics

EDUCATION: B.A.: Biology; St. Louis University, St. Louis, Missouri, 1980 Ph.D.: Molecular Biology; Washington University, St. Louis, Missouri, 1987

PROFESSIONAL APPOINTMENTS: 1980-1981 Research Technologist, Department of Dermatology, Washington University School of

Medicine, St. Louis, MO 1981-1983 Research Technologist, Dept. of Biological Chemistry, Washington University School of

Medicine, St. Louis, MO 1981-1983 Research Associate, Department of Biological Chemistry, Washington University School of

Medicine, St. Louis, MO 1989 Research Assistant Professor, Dept. of Biochemistry and Molecular Biophysics, Washington

University School of Medicine, St. Louis, MO 1990-1996 Assistant Professor, Department of Biochemistry, Albert Einstein College of Medicine, Bronx,

NY 1996-Present Professor, Department of Biochemistry and Biophysics, Texas A&M University, College

Station, TX 1996-Present Wolfe-Welch Chair in Sciences, Texas A&M University, College Station, TX 1997-Present Professor, Department of Chemistry, Texas A&M University, College Station, TX 1997-2001 Member, Biochemistry Study Section, NIH 1998-Present Chair, Texas A&M Life Sciences Task Force 1998-Present Professor, Albert B. Alkek Institute of Biosciences & Technology, Texas A&M University,

Houston, TX 2001-Present Director, Center for Structural Biology, Texas A&M University 2004-2005 Chair, Texas A&M Council of Principle Investigators 2004-Present Director, TB Structural Genomics Consortium 2005 Chair, Tuberculosis Drug Discovery, Gordon Research Conference

PEER-REVIEWED PUBLICATIONS : (From 250 peer reviewed publications) 55. Reddy M., Breda A., Bruning J., Sherekar M., Valluru S., Thurman C., Ehrenfeld H., Sacchettini J.

(2014) Structure, Activity, and Specific Inhibition of the Carboxyltransferase β-subunit of Acetyl-CoACarboxylase (AccD6) from Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy: UnderReview

54. Shi X, Festa R. A., Ioerger T. R., Butler-Wu S., Sacchettini J. C., Darwin K. H., Samanovic M. I. (2014)The Copper-Responsive RicR Regulon Contributes to Mycobacterium tuberculosis Virulence. MBio; 5(1).pii: e00876-13.

53. Lin P. L., Ford C. B., Coleman M.T., Myers A. J., Gawande R., Ioerger T., Sacchettini J., Fortune S. M.,Flynn J. L. (2014) Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing. Nat Med; 20(1):75-9.52.

52. Zhang Y. J., Reddy M. C., Ioerger T. R., Rothchild A. C., Dartois V., Schuster B. M., Trauner A., WallisD., Galaviz S., Huttenhower C., Sacchettini J. C., Behar S. M., Rubin E. J. (2013) Tryptophanbiosynthesis protects mycobacteria from CD4 T-cell-mediated killing. Cell; 155(6):1296-308.

51. Ngubane N. A., Gresh L., Ioerger T. R., Sacchettini J. C., Zhang Y. J., Rubin E. J., Pym A., Khati M.(2013) High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria.PLoS One; 8(11):e77844.

50. Ioerger T. R., O'Malley T., Liao R., Guinn K. M., Hickey M. J., Mohaideen N., Murphy K. C., Boshoff H.I., Mizrahi V., Rubin E. J., Sassetti C. M., Barry C. E. 3rd, Sherman D. R., Parish T., Sacchettini J. C.(2013) Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis.PLoS One; 8(9):e75245.

49. Mosser R., Reddy M. C., Bruning J. B., Sacchettini J. C., Reinhart G. D. (2013) Redefining the Role ofthe Quaternary Shift in Bacillus stearothermophilus Phosphofructokinase. Biochemistry;52(32):5421-9.

48. Stanley S. A., Kawate T., Iwase N., Shimizu M., Clatworthy A. E., Kazyanskaya E., Sacchettini J. C.,Ioerger T. R., Siddiqi N. A., Minami S., Aquadro J. A., Grant S. S., Rubin E. J., Hung D. T. (2013)Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targetingFadD32. Proc Natl Acad Sci U S A. 110(28):11565-70.

47. Lanzas F, Karakousis P. C., Sacchettini J. C., Ioerger T. R. (2013) Multidrug-resistant tuberculosis inPanama is driven by clonal expansion of an MDR-TB strain related to the KZN XDR-TB strain fromSouth Africa. J Clin Microbiol;51(10):3277-85.

46. Ioerger T. R., O’Malley T., Liao R., Guinn K. M., Hickey M. J., Mohaideen N, Murphy K. C., Boshoff H.I., Mizrahi V., Rubin E. J., Sassetti C. M., Barry C. E., Sherman D. R., Parish T., Sacchettini J. C. (2013)Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis, PLoSOne.

45. Gulten G., Sacchettini J.C. (2013) Structure of the Mtb CarD/RNAP β-lobes complex reveals themolecular basis of interaction, and presents a novel DNA binding domain for Mtb CarD. Structure.21(10):1859-69.

44. Small J. L., Park S. W., Kana B. D., Ioerger T. R., Sacchettini J. C., Ehrt S. (2013) Perturbation ofcytochrome c maturation reveals adaptability of the respiratory chain in Mycobacterium tuberculosis.MBio. 4(5):e00475-13.

43. DeJesus M. A., Sacchettini J. C., Ioerger T. R. (2013) Reannotation of translational start sites in thegenome of Mycobacterium tuberculosis, Tuberculosis (Edinb). 93(1):18-25

42. DeJesus M. A., Zhang Y. J., Sassetti C. M., Rubin E. J., Sacchettini J. C., Ioerger T. R. (2013) Bayesiananalysis of gene essentiality based on sequencing of transposon insertion libraries, Bioinformatics.29(6):695-703

41. Kim Y., Cunningham M. A., Mire J., Tesar C., Sacchettini J., Joachimiak A. (2013) NDM-1, the ultimatepromiscuous enzyme: substrate recognition and catalytic mechanism, FASEB J. 27(5):1917-27

40. Liu Z., Ioerger T. R., Wang F., Sacchettini J. C. (2013) Structures of Mycobacterium tuberculosisFadD10 protein reveal a new type of adenylate-forming enzyme, J Biol Chem. 288(32):23435.

39. Gokulan K, O'Leary S. E., Russell W. K., Russell D. H., Lalgondar M., Begley T. P., Ioerger T. R.,Sacchettini J. C. (2013) Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11)reveals intermediates in the synthesis of methyl-branched alkylpyrones, J Biol Chem. 288(23):16484-94

38. Krieger, I.V., Freundlich, J.S., Gawandi, Vijay B., Roberts, J.P., Gawandi, Vidyadhar B., Sun, Q.,Owen,J.L., Fraile, M.T., Huss, S., Duncan, K., Lavandera J.-L., Ioerger, T.R., Sacchettini, J.C., (2012)Structure-guided Discovery of Phenyl diketo-acids as Potent Inhibitors of M. tuberculosis MalateSynthase, Chemistry & Biology, 19(12):1556-67

37. James, J. N., Hasan, Z. U., Ioerger, T. R., Brown, A. C., Personne, Y., Carroll, P., Ikeh, M., Tilston-Lunel,N. L., Palavecino, C., Sacchettini, J. C., and Parish, T. (2012) Deletion of SenX3-RegX3, a key two

component regulatory system of Mycobacterium smegmatis, results in growth defects under phosphate-limiting conditions, Microbiology, 158(Pt 11):2724-31.

36. Chia, B. S., Lanzas, F., Rifat, D., Herrera, A., Kim, E. Y., Sailer, C., Torres-Chavolla, E.,Narayanaswamy, P., Einarsson, V., Bravo, J., Pascale, J. M., Ioerger, T. R., Sacchettini, J. C., andKarakousis, P. C. (2012) Use of multiplex allele-specific polymerase chain reaction (MAS-PCR) to detectmultidrug-resistant tuberculosis in Panama, PLoS One 7, e40456.

35. Moussa, S. H., Kuznetsov, V., Tran, T. A., Sacchettini, J. C., and Young, R. (2012) Protein determinantsof phage T4 lysis inhibition, Protein Sci 21, 571-582.

34. Mosser, R., Reddy, M. C., Bruning, J. B., Sacchettini, J. C., and Reinhart, G. D. (2012) Structure of theapo form of Bacillus stearothermophilus phosphofructokinase, Biochemistry 51, 769-775.

33. La Rosa, V., Poce, G., Canseco, J. O., Buroni, S., Pasca, M. R., Biava, M., Raju, R. M., Porretta, G. C.,Alfonso, S., Battilocchio, C., Javid, B., Sorrentino, F., Ioerger, T. R., Sacchettini, J. C., Manetti, F.,Botta, M., De Logu, A., Rubin, E. J., and De Rossi, E. (2012) MmpL3 is the cellular target of theantitubercular pyrrole derivative BM212, Antimicrob Agents Chemother 56, 324-331.

32. Bruning, J. B., Murillo, A. C., Chacon, O., Barletta, R. G., and Sacchettini, J. C. (2011) Structure of theMycobacterium tuberculosis D-alanine:D-alanine ligase, a target of the antituberculosis drug D-cycloserine, Antimicrobial agents and chemotherapy 55, 291-301.

31. Arockiasamy, A., Aggarwal, A., Savva, C. G., Holzenburg, A., and Sacchettini, J. C. (2011) Crystalstructure of calcium dodecin (Rv0379), from Mycobacterium tuberculosis with a unique calcium-bindingsite, Protein Sci 20, 827-833.

30. Gokulan, K., Aggarwal, A., Shipman, L., Besra, G. S., and Sacchettini, J. C. (2011) Mycobacteriumtuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations,Acta Crystallogr D Biol Crystallogr 67, 657-669.

29. Ford, C. B., Lin, P. L., Chase, M. R., Shah, R. R., Iartchouk, O., Galagan, J., Mohaideen, N., Ioerger, T.R., Sacchettini, J. C., Lipsitch, M., Flynn, J. L., and Fortune, S. M. (2011) Use of whole genomesequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection, Nat Genet43, 482-48618

28. Dias, M. V., Snee, W. C., Bromfield, K. M., Payne, R. J., Palaninathan, S. K., Ciulli, A., Howard, N. I.,Abell, C., Sacchettini, J. C., and Blundell, T. L. (2011) Structural investigation of inhibitor designstargeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis,Biochem J 436, 729-739.

27. Shetty, N. D., Reddy, M. C., Palaninathan, S. K., Owen, J. L., and Sacchettini, J. C. (2010) Crystalstructures of the apo and ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein, ProteinSci 19, 1513-1524.

26. Kong, Y., Yao, H., Ren, H., Subbian, S., Cirillo, S. L., Sacchettini, J. C., Rao, J., and Cirillo, J. D. (2010)Imaging tuberculosis with endogenous beta-lactamase reporter enzyme fluorescence in live mice,Proceedings of the National Academy of Sciences of the United States of America 107, 12239-12244.

25. Kalscheuer, R., Syson, K., Veeraraghavan, U., Weinrick, B., Biermann, K. E., Liu, Z., Sacchettini, J. C.,Besra, G., Bornemann, S., and Jacobs, W. R., Jr. (2010) Self-poisoning of Mycobacterium tuberculosis bytargeting GlgE in an alpha-glucan pathway, Nat Chem Biol 6, 376-384.

24. Ioerger, T. R., Feng, Y., Ganesula, K., Chen, X., Dobos, K. M., Fortune, S., Jacobs, W. R., Jr., Mizrahi,V., Parish, T., Rubin, E., Sassetti, C., and Sacchettini, J. C. (2010) Variation among genome sequences ofH37Rv strains of Mycobacterium tuberculosis from multiple laboratories, Journal of bacteriology 192,3645-3653.

BIOGRAPHICAL SKETCH Provide the following information for all key personnel and other significant contributors in the order listed on Form Page 2.

Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE

SAFE, Stephen H. Distinguished Professor eRA COMMONS USER NAME

ssafe1 EDUCATION (Begin with baccalareate or other initial professional education, such as nursing, and include postdoctoral training.)


Queen's University - Canada B.S. 1962 Chemistry Queen's University - Canada M.S. 1963 Chemistry Oxford University - Great Britain D.Phil. 1965 Bioorganic Chemistry Oxford University - Great Britain Res. Asst. 1966 Bioorganic Chemistry Harvard University - USA Res. Assoc. 1967 Biochemistry

A. POSITIONS AND HONORS

Professional Experience 1968-1973 Research Officer, National Research Council of Canada 1973-1981 Associate to Full Professor, Department of Chemistry, University of Guelph 1981-1984 Professor, Department of Veterinary Physiology & Pharmacology, Texas A&M University 1984- Distinguished Prof., Dept. of Veterinary Physiology & Pharmacology, Texas A&M University 2001- Director, Center for Environmental & Genetic Medicine, Institute of Biosciences & Technology,

Texas A&M Health Science Center

Honors and Awards 1976 - Sigma Xi Award for Excellence in Research, University of Guelph; 1978 - Queen's Silver Jubilee Medal; 1984 - Royal Society of Chemistry Award for Safety, Health or Environmental Chemistry; 1988 - DistinguishedAchievement Award in Research, Texas A&M University; 1989-1994 - Burroughs Wellcome Toxicology ScholarAward; 1991 - Sid Kyle Chair in Toxicology, Texas A&M University; 1991-1992 - University Lecturer, Texas A&MUniversity; 1995 - Distinguished Achievement Award in Research, Sigma XI; 1995 - Eli Lilly Science and SocietyLecturer, Indiana State University; 1996 - Samuel Kuna Distinguished Lecturer, Rutgers University - UMDNJ; 1996 -Honorary Doctorate in Science, University of Guelph; 1998 - McEwen Lecturer, Queen’s University; 2002 - ISI, MostHighly Cited Research in Pharmacology and in Ecology/Environment; 2003 - Spirit of Innovation Award, TechnologyLicensing Office, Texas A&M University; 2004 - Jo Ann Treat Award for Excellence in Research, Texas A&MResearch Foundation; 2005 - Texas A&M University Former Students Association Distinguished AchievementAward for Research; 2006 - Regents Professor, Texas A&M University System; 2007 - Distinguished LifetimeToxicology Scholar Award, Society of Toxicology; 2014 - Excellence in Innovation Award, Texas A&M Technologyand Commercialization

B. SELECTED REPRESENTATIVE PUBLICATIONS (Refereed - >700; Books - 5)Safe, S.H., Prather, P.L., Brents, L.K., Chadalapaka, G. and Jutooru, I. Unifying mechanisms of action of the

anticancer activities of triterpenoids and synthetic analogs. Anticancer Agents Med. Chem. 12:1211-1220, 2012. Pathi S., Jutooru, I., Chadalapaka, G., Nair, V., Lee, S-O. and Safe, S. Aspirin inhibits colon cancer cell and tumor

growth and downregulates specificity protein (Sp) transcription factors. PLoS One 7:e48208, 2012. Free Article Gandhy, S.U., Kim, K., Larsen, L., Rosengren, R.J. and Safe, S. Curcumin and synthetic analogs induce reactive

oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs. BMC Cancer 12:564, 2012. Free Article

Safe, S., Chadalapaka, G. and Jutooru, I. AHR-reactive compounds in the human diet. In: The Ah Receptor in Biology and Toxicology (Pohjanvirta, R., ed.). John Wiley and Sons, Hoboken, NJ. pp. 331-342, 2012.

Kim, K., Jutooru, I., Chadalapaka, G., Johnson, G., Frank, J., Burghardt, R., Kim, S. and Safe, S. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene 32:1616-1625, 2013. PMC3484248

Safe, S., Lee, S.O. and Jin, U.H. Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target. Toxicol. Sci. 135:1-16, 2013. PMC3748760

Nair, V., Pathi, S., Jutooru, I., Sreevalsan, S., Basha, R., Abdelrahim, M., Samudio, I. and Safe, S. Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors. Carcinogenesis 34:2870-2879, 2013. PMC3845888

Boakye, C.H., Doddapaneni, R., Shah, P.P., Patel, A.R., Godugu, C., Safe, S., Katiyar, S.K. and Singh, M. Chemoprevention of skin cancer with 1,1-bis(3'-indolyl)-1-(aromatic)methane analog through induction of the orphan nuclear receptor, NR4A2 (Nurr1). PLoS One 8:e69519, 2013. PMC3737220

Sreevalsan, S. and Safe, S. The cannabinoid WIN 55,212-2 decreases specificity protein (Sp) transcription factors and the oncogenic cap protein eIF4E in colon cancer cells. Mol. Cancer Ther. 12:2483-2493, 2013.

Patel, A.R., Chougule, M.B., Lim, E., Francis, K.P., Safe, S. and Sachdeva, M. Theranostic tumor homing nanocarriers for the treatment of lung cancer. Nanomedicine 10:1053-1063, 2014. PMC4061286

Safe, S., Jin, U.H., Hedrick, E., Reeder, A. and Lee, S.O. Minireview: Role of orphan nuclear receptors in cancer and potential as drug targets. Mol. Endocrinol. 28:157-172, 2014. PMC3896638

Jutooru, I., Guthrie, A.S., Chadalapaka, G., Pathi, S., Kim, K.H., Burghardt, R., Jin, U.H. and Safe, S. Mechanism of action of phenethylisothiocyanate and other ROS-inducing anticancer agents. Mol. Cell. Biol. 34:2382-2395, 2014. PMC4054319

Zhang, Z., Kim, K., Li, X., Moreno, M., Sharp, T., Goodheart, M.J., Safe, S., Dupuy, A.J. and Amendt, B.A. MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 (LEF-1) expression. Mol. Cancer Ther. 13:1942-1951, 2014. PMC4090280

Ying, W., Kanameni, S., Chang, C.A., Nair, V., Safe, S. Bazer, F.W. and Zhou, B. Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization. PLoS One 9:e98835, 2014. PMC4048269

Jin, U.H., Lee, S.O., Pfent, C. and Safe, S. The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis. BMC Cancer 14:498, 2014. Free article

Lee, S.O., Li, X., Hedrick, E., Jin, U.H., Tjalkens, R.B., Backos, D.S., Li L., Zhang, Y., Wu, Q. and Safe, S. Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells. Mol. Endocrinol. 28, 1729-1739, 2014. PMC4179635

Nair, V., Sreevalsan, S., Basha, R., Abdelrahim, M., Abudayyeh, A., Rodrigues Hoffman, A. and Safe, S.H. Mechanism of metformin-dependent inhibition of mTOR and Ras activity in pancreatic cancer: role of Sp transcription factors. J. Biol. Chem. 289:27692-27701, 2014. PMC4183806

De Miranda, B.R., Popichak, K.A., Hammond, S.L., Miller, J.A., Safe, S. and Tjalkens R.B. Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease. Toxicol. Sci. in press, 2014.

Yang, W.S., Chadalapaka, G., Cho, S.G., Lee, S.O., Jin, U.H., Jutooru, I., Choi, K., Leung, Y.K., Ho, S.M., Safe, S. and Kim, K. The transcriptional repressor ZBTB4 regulates EZH2 through a microRNA-ZBTB4-specificity protein signaling axis. Neoplasia 16:1059-1069, 2014.

D. ONGOING RESEARCH PROJECTSR01-CA142697 (Role: PI) 07/01/10 – 06/30/15 1.2 calendarNational Cancer InstituteMolecular Mechanisms and Application of Ah Receptor-MicroRNA InteractionsThese studies will characterize the molecular mechanisms of AhR-miR interactions and development of SAhRMs forclinical applications in the treatment of ER-negative breast cancer.

W81XWH-11-1-0211 (Role: Co-PI) 04/01/11 – 03/31/15 0.6 calendar DOD – Partnership Training Award The Role of Novel Substituted Diindolylmethane Analogs in the Treatment of Triple Negative Breast Cancer This project will involve mentoring and research on development of new mechanism-based anticancer drugs. (PI: M. Sancheva, FAMU)

P30-ES023512 (PI: C. Walker) 02/01/14 - 01/31/17 1.2 calendar NIEHS $0 ($600,000/yr) Center for Translational Environmental Health Research The objectives are to: 1) Build programmatic and scientific capacity for environmental health science research through member participation; 2) Integrate investigators with different expertise, support acquisition of new expertise by Center members and the development of promising new investigators; 3) Enhance the capabilities of existing programs in environmental health sciences; 4) Serve as a resource for information and expertise to surrounding communities, stakeholders, and Center members.

Program Director/Principal Investigator (Last, First, Middle): SIEGELE, Deborah A.




NAME Siegele, Deborah A.

POSITION TITLE Associate Professor Dept. of Biology Texas A&M University

eRA COMMONS USER NAME (credential, e.g., agency login) dsiegel EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)


Northwestern University, Evanston, IL B.A. 1976 Biochemistry University of Wisconsin, Madison, WI Ph.D. 1989 Molecular & Cell Biology Harvard Medical School, Boston, MA Post-doc. 1989-92 E. coli mol. genetics

A. Positions and Honors.

Employment 1992-1997 Assistant Professor, Dept. of Biology, Texas A&M University, College Station,

TX 9/2003-8/2006

Graduate Advisor, Dept. of Biology, Texas A&M University, College Station, TX

1996-present Member, Graduate Faculty of Genetics, Texas A&M University, College Station, TX

2002-present Member, Professional Program in Biotechnology, Texas A&M University 1997-present Associate Professor, Dept. of Biology, Texas A&M University, College Station,

TX

Other Experience and Professional Memberships EcoliHub Steering Committee, 2006-2009 Member, Genetics Society of America Board of Directors, 2013-2015 American Society for Microbiology Genetics Society of America

Honors Support on NIH Cell and Molecular Biology Training Grant, University of Wisconsin 1983-85 NIH Postdoctoral Fellowship, 1990-1992

B. Selected peer-reviewed publications (Graduate students and undergraduates as shown.)

1) Hu, J.C., G. Sherlock, D.A. Siegele, S.A. Aleksander, C.A. Ball, J. Demeter, S. Gouni, N.M. Liles, B.K. McIntosh, H. Mi, A. Muruganujan, F. Wymore, and P.D. Thomas. (2014) PortEco: a resource for exploring bacterial biology through high-throughput data and analysis tools. Nucleic Acids Res. 42(Database issue):D677-84.

2) Lim, B., R. Miyasaki, S. Neher, D.A. Siegle, K. Ito, P. Walter, Y. Akiyama, T. Yura, and C.A. Gross. (2013) Heat shock transcription factor sigma32 co-opts the signal recognition particle to regulate protein homeostasis in E. coli. PLoS Biol. 11:31001735.

2) Renfro DP, McIntosh BK, Venkatraman A, Siegele DA & Hu JC (2012) GONUTS: the Gene Ontology Normal Usage Tracking System. Nucleic Acids Res 40: D1262-9. PMCID: PMC3245169

4) McIntosh BK, Renfro DP, Knapp GS, Lairikyengbam CR, Liles NM, Niu L, Supak AM, Venkatraman A, Zweifel AE, Siegele DA & Hu JC (2012) EcoliWiki: a wiki-based community resource for Escherichia coli. Nucleic Acids Res 40: D1270-7. PMCID: PMC3245172

5) Siegele, D.A., S. Bain, and W. Mao (2010) Mutations in the flhD gene of Escherichia coli K-12 do not cause the reported effect on cell division. FEMS Microbiol. Lett. 309:94-9.

Program Director/Principal Investigator (Last, First, Middle): SIEGELE, Deborah A.


6) Hu, J.C, Karp, P. Keseler, I, Krummenacker, M, and Siegele DA (2009) What we can learn about Escherichia coli through application of Gene Ontology. Trends in Microbiology. 7:269-78. PMCID: PMC357575

7) Reference Genome Group of the Gene Ontology Consortium (2009) The Gene Ontology's Reference Genome Project: a unified framework for functional annotation across species. PLoS Comput Biol. 2009 Jul;5(7):e1000431. PMCID: PMC2699109

8) Typas, A., R.J. Nichols, D.A. Siegele, M. Shales, S.R. Collins, B. Lim, H. Braberg, N. Yamamoto, R. Takeuchi, B.L. Wanner, H. Mori, J.S. Weissman, N.J. Krogan, and C.A. Gross (2008) High-throughput, quantitative analyses of genetic interactions in E. coli. Nature Methods 5:781-787.

9) Champion, M.M., C.S. Campbell, D.A. Siegele, D.H. Russell, and J.C. Hu (2003) Proteome analysis of Escherichia coli K-12 by two-dimensional native-state chromatography and MALDI-MS. Mol. Microbiol. 47: 383-96.

10) Arnold, C.N., J. McElhanon, A. Lee, R. Leonhart, and D.A. Siegele (2001) Global analysis of Escherichia coli gene expression during the acetate-induced acid tolerance response. J. Bacteriol. 183: 2178-86.

11) Mao, W. and D.A. Siegele (1998) Genetic analysis of the stationary phase-induced mcb operon promoter in Escherichia coli. Mol. Microbiol. 27:415-24.

12) Siegele, D.A. and J.C. Hu (1997) Gene expression from plasmids containing the araBAD promoter at subsaturating inducer concentrations represent mixed populations. Proc. Natl. Acad. Sci. USA 94:8168-72.

13) Siegele, D.A. and L.J. Guynn (1996) Escherichia coli proteins synthesized during recovery from starvation. J. Bacteriol. 178: 6352-6.

14) Siegele, D.A., K.R. Imlay, and J.A. Imlay (1996) The stationary-phase-exit defect of cydC (surB) mutants is due to the lack of a functional terminal cytochrome oxidase. J. Bacteriol. 178: 6091-6.

Program Director/Principal Investigator (Last, First, Middle): Skow, Loren C.

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.


NAME Skow, Loren Curtis

POSITION TITLE Professor of Genetics

eRA COMMONS USER NAME (credential, e.g., agency login)

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)


Abilene Christian University M.S. 1970 Biology Texas A&M University Ph.D. 1976 Fisheries Science The Jackson Laboratory Post-Doc 1978 Biomedical Genetics

A. Personal StatementI am a Professor in the Department of Veterinary Integrative Biosciences and a member of the Interdisciplinary GraduateFaculty of Genetics. My research is focused on comparative organization and expression of the mammalian genome withspecial emphasis on genes involved in host resistance to disease. A primary goal is to determine the genomic sequences ofthe bovine and equine major histocompatibility complexes and understand how genetic differences in these genomicregions translate into functional differences in the immune response directed against intracellular and extracellularpathogens. Specific attention is focused on individual animal variation in the genes encoding class I and class II receptorsfor antigen presentation and exploitation of this variation to develop more effective immune therapies. I was one of theprincipal authors of the NIH White Paper that initiated the bovine genome sequencing project and have served as chair ofthe Texas A&M Graduate Faculty of Genetics.

B. Positions and HonorsProfessional Employment:1970 Graduate Instructor in Biology, Abilene Christian University, Abilene, Tx. 1971 Research Assistant in Fisheries Science, Texas A&M University, College Station, Tx. 1972 Rotary International Graduate Fellow in Biology, University of Queensland, Australia. 1973-1976 Research Assistant in Fisheries Science, Texas A&M University, College Station, Tx. 1976-1978 NIH Postdoctoral Trainee Biomedical Genetics, The Jackson Laboratory, Bar Harbor, Me 1978-1979 Research Associate, Univ. of Tennessee Graduate School of Biomedical Science, Oak Ridge, Tn. 1979-1981 Research Scientist, Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tn. 1981-1985 Senior Staff Fellow, Eukaryotic Gene Structure Section, Laboratory of Genetics, National Institute of

Environmental Health Sciences, Research Triangle Park, NC. 1985-1993 Associate Professor, Department of Veterinary Anatomy, College of Veterinary Medicine, Texas A&M

University, College Station, Tx. 1993-current Professor, Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and

Biomedical Sciences, Texas A&M University, College Station, Tx

C. Selected Peer Reviewed Publications. (last five years, from total of 95):

1. The Bovine Hapmap Consortium. Genome Wide Survey of SNP Variation Uncovers the Genetic Structure of CattleBreeds. 2009. Science (324(5926):528-532.

2. The Bovine Genome Sequencing and Analysis Consortium, The Genome Sequence of Taurine Cattle: A window toruminant biology and evolution. 2009. Science. 324(5926):522-528.

3. Brinkmeyer-Langford CL, Childers CP, Fritz K, Gustafson-Seabury A, Cothran M, Raudsepp T, Womack JE, SkowLC. A high resolution RH map of the bovine major histocompatibility complex. 2009. BMC Genomics 10:182-192.


Program Director/Principal Investigator (Last, First, Middle): Skow, Loren C.

4. Wade CM, Giulotto E, Sigurdsson S, Zoli M, Gnerre S, Imsland F, Lear TL, Adelson DL, Bailey E, Bellone RR,Blöcker H, Distl O, Edgar RC, Garber M, Leeb T, Mauceli E, MacLeod JN, Penedo MCT, Baison JM, Sharpe T,Vogel J, Andersson L, Antczak DF, Biagi T, Binns MM, Chowdhary BP, Coleman SJ, Della Valle G, Fryc S, GuérinG, Hasegawa T, Hill EW, Jurka J, Kiialainen A, Lindgren G, Liu J, Magnani E, Mickelson JR, Murray J, NergadzeSG, Onofrio R, Pedroni S, Piras MF, Raudsepp T, Rocchi M, Røed KH, Ryder OA, Searle S, Skow L, Swinburne JE,Syvänen AC, Tozaki T, Valberg SJ, Vaudin M, White JR, Zody MC. Genome sequence, comparative analysis andpopulation genetics of the domestic horse (Equus caballus). Science (2009) Nov 6; 326(5954):865-7.

5. Sena L, Schneider M P C, Brenig BB, Honeycutt RL, Honeycutt DA, Womack JE and Skow LC. Polymorphismand gene organization of Bubalus bubalis MHC-DQB show homology to BoLA DQB region. Animal Genetics(2010). Animal Genetics. 2011 Aug;42(4):378-85.

6. Brinkmeyer-Langford CL, Murphy WJ, Childers, CP, and Skow LC. A conserved segmental duplication withinELA. Animal Genetics (2010) 41 Suppl 2:186-195.

7. Brinkmeyer-Langford CL, Huber II JC, Gill CA and Skow LC. Microsatellite variation in the equine MHC.Anim Genetics (2012) 44(3) :267-75.

8. Doan R, Cohen N, Harrington J, Veazy K, Juras R, Cothran G, McCue ME, Skow L, Dindot SV. Identification ofcopy number variants in horses. Genome Res.( 2012) 5:899-907.

9. Stafuzza, NB, Greco AJ, Grant JR, Abbey CA, Gill CA, Raudsepp T, Skow LC, WomackJE, Riggs PK and AmaralMEJ. A high resolution radiation hybrid map of the river buffalo major histocompatibility complex (MHC) andcomparison with BoLA. Animal Genetics (2013) 44(4):369-376.

10. Fritz KL, Kaese HJ, Valberg SJ, Hendrickson JA, Rendahl AK, Bellone RR, Dynes KM, WagnerML, Lucio MA, Cuomo FM, Brinkmeyer-Langford CL, Skow LC, Mickelson JR,RutherfordMS, McCue ME. Genetic risk factors for insidious equine recurrent uveitis in Appaloosahorses. Anim Genetics 2014 Jun;45(3):392-9.

D. Research SupportCurrent Funding:

68004-30367 (Skow, Co-PI) 4/15/2011- 4/14/2016 .6 calendar months USDA-NIFA-AFRI. Integrated Program for Reducing Bovine Respiratory Disease Complex in Beef and Dairy Cattle. (2011). Synopsis: The goal of this study is to identify genetic variants underlying resistance to bovine respiratory disease complex in cattle.


Principal Investigator STELLY, David M.




NAME Stelly, David M.

POSITION TITLE Associate Professor of Soil & Crop Science at Texas A&M University (TAMU) eRA COMMONS USER NAME



University of Wisconsin B.Sc. 1975 Genetics Iowa State University M.Sc. 1979 Plant Breeding & Cyto.

University of Wisconsin Ph.D 1983 Plant Breeding & Plant Gene.

A. Positions and Honors.Positions and Employment2000-present Professor, Faculty of Molecular & Environmental Plant Sciences (MEPS) 1997-2000 Professor, Dept. Forest Sciences FRSC: (joint appt.) 1993-present Professor, Dept. Soil & Crop Sciences (SCSC), and Faculty of Genetics (GENE) 1996-2006 Director, Laboratory for Plant Molecular Cytogenetics (LPMC) 1989-1993 Associate Professor, SCSC, and GENE 1983-1989 Assistant Professor, SCSC, and GENE

HONORS, AWARDS AND MEMBERSHIPS 1995: Cotton Genetics Award 2008: Cotton Genetics Award (member of 3-person team) 2002: International Cotton Genome Initiative (ICGI) - First elected Chair 2007: Elected Chair, Science & Technology, Plant Breeding Coordination Committee (2007-2009) 2009 Elected as Secretary (2010), Vice-President (2011), President (2012) and Past-President (2013),

National Association of Plant Breeders. 2009-: Chair, P&T Committee, Dept. Soil & Crop Sciences, TAMU 2012: Elected as Co-Chair 2013-2015 and Chair 2015-17, International Cotton Genome Initiative

(ICGI)). 2013: Research Award for 2012, Dept. Soil & Crop Sciences, TAMU Memberships: AAAS, Crop Science Society of America, National Association of Plant Breeders, Int'l

Cotton Genome Initiative, Sigma Xi

B. Selected peer-reviewed publications (in chronological order).

ILLUSTRATIVE RECENT PUBLICATIONS OF LAB RESEARCH (*postdoc & †student) 1. Bell, A.A., A.F. Robinson, J. Quintana, N.D. Dighe†, M.A. Menz, D.M. Stelly, X. Zheng†, J.E. Jones, C.

Overstreet, E. Burris, R.G. Cantrell, and R.L. Nichols. 2014. Registration of LONREN-1 andLONREN-2 Germplasm Lines of Upland Cotton Resistant to Reniform Nematode. J. Plant Reg. XXX-XXX. doi:10.3198/jpr2013.11.0069crg

2. Bell, A.A., A.F. Robinson, J. Quintana, S.E. Duke, J.L. Starr, D.M. Stelly, X. Zheng†, S. Prom, V.Saladino, O.A. Gutiérrez, S.R. Stetina and R.L. Nichols. 2014. REGISTRATION OF BARBREN-713Germplasm Line of Upland Cotton Resistant to Reniform and Root-Knot Nematodes.

Principal Investigator STELLY, David M.


3. De Donato, M. †, R.A. Brenneman, D.M. Stelly, J.E. Womack and J.F. Taylor. 2004. A methodologicalapproach for the construction of a radiation hybrid map of bovine chromosome 5. Genetics andMolecular Biology, 27, 1, 22-32.

4. Dighe, N.† , A.F. Robinson, A.A. Bell, M. Menz, R. Cantrell and D.M. Stelly. (2009.) Linkage mappingof resistance to reniform nematode in cotton (Gossypium hirsutum L.) following introgression from G.longicalyx (Hutch. & Lee). Crop Science 49:1151-1164.

5. Gao, W. †, Z. J. Chen, J. Z. Yu, D. Raska, R. J. Kohel, J. E. Womack, and D. M. Stelly. 2004. Wide-cross whole-genome radiation hybrid (WWRH) mapping of cotton (Gossypium hirsutum L.). Genetics167 (3): 1317-1329.

6. Gao, W. †, Z. J. Chen, J. Z. Yu, R. J. Kohel, J. E. Womack, D. M. Stelly. 2006. Wide-cross whole-genome radiation hybrid mapping of the cotton (Gossypium barbadense L.) genome, MolecularGenetics and Genomics 275:105-113. DOI: 10.1007/s00438-005-0069-5 (New method to physicallymap the cotton genome.)

7. Guan X, Lee JJ, Pang M, Shi X, Stelly DM and Z. Jeffrey Chen. 2011. Activation of arabidopsis seedhair development by cotton fiber-related genes. PLoS ONE 6(7): e21301.doi:10.1371/journal.pone.0021301 (towards an A.t. platform for exploring fiber dev. control)

8. Ji, Y. †, X, Zhao, A, H. Paterson, H. J, Price and D. M. Stelly. 2007. Integrative mapping ofGossypium hirsutum L. by meiotic flourescent in situ hybridization of a tandemly repetitive sequence(B77). Genetics 176: 115-123.

9. Kim, J. †, P. E. Klein, R. R. Klein, H. J. Price, J. E. Mullet, and D. M. Stelly. 2005. Chromosomeidentification and nomenclature of Sorghum bicolor. Genetics 169: 1169–1173. doi:10.1534/genetics.104.035980.

10. Kim, J.-S. †, M. N. Islam-Faridi *, P. E. Klein, D. M. Stelly, H. J. Price, R. R. Klein, and J. E. Mullet.2005. Comprehensive molecular cytogenetic analysis of sorghum genome architecture: distribution ofeuchromatin, heterochromatin, genes and recombination in comparison to rice. Genetics 171:1963-1976.

11. Lee, J. J.,O. S. S. Hassan, W. Gao †, N. E. Wei, R. J. Kohel, X-Y Chen, P. Payton, S-H Sze, D. M.Stelly, Z. J. Chen. 2006. Developmental and gene expression analyses of a cotton naked seedmutant, Planta 223:418-432.

12. Mei, M., N. H. Syed, W. Gao †, P. M. Thaxton, C. W. Smith, D. M. Stelly and Z. J. Chen. 2004.Genetic mapping and QTL analysis of fiber-related traits in cotton (Gossypium). Theor Appl Genet108:280–291.

13. Page, J.T., M.D. Huynh, Z.S. Liechty, K. Grupp, D. Stelly, A.M. Hulse†, H. Ashrafi, A. Van Deynze, J.Wendel, and J.A. Udall. 2013. Insights into the evolution of cotton diploids and polyploids from whole-genome re-sequencing. G3: GENES, GENOMES, GENETICS 3:1809-1818.

14. Paterson, A H., et al. (D. M. Stelly). 2012. The cotton genomes, their polyploidies, and the evolutionof spinnable fibers. Nature 492:423-428. (x. useful resource for cotton genomics)

15. Saha, S., Stelly, D.M., Raska, D.A., Wu, J., Jenkins, J.N., McCarty, Jr., J.C., Makamov, A., Gotmare,V., Abudurakhmonov, I., Campbell, B.T. 2012. Chromosome substitution lines: Concept, developmentand utilization in the genetic improvement of upland cotton. In: Abdurakhmoov, I.Y., editor. PlantBreeding. InTech. p. 107-128. (uses of hypoaneuploids)

16. Van Deynze, A., K. Stoffel, M. Lee, T.A. Wilkins, A. Kozik, R.G. Cantrell, J.Z. Yu, R.J. Kohel, D.M.Stelly. Sampling nucleotide diversity in cotton. BMC Plant Biology 2009, 9:125-136. (Early SNPdevelopment in cotton.)

17. Yu, J., Kohel, R.J., Fang, D.D., Cho, J., Van Deynze, A., Ulloa, M., Hoffman, S.M., Pepper, A.E.,Stelly, D.M., Jenkins, J.N., Saha, S., Kumpatla, S.P., Shah, M.R., Hugie, W.V., Percy, R.G. 2012. Ahigh-density simple sequence repeat and single nucleotide polymorphism genetic map of the tetraploidcotton genome. Genes, Genomes, Genetics 2:43-58. doi: 10.1534/g3.111.001552http://www.g3journal.org/content/2/1/43.abstract (useful resource)

CURRICULUM VITA

Terry L. Thomas

Department of Biology Texas A&M University

College Station, TX 77843 Phone: (979) 845-0184 FAX: (979) 847-8805

[email protected]

EDUCATION

University of Georgia B.S. Chemistry, Zoology 1972 University of Georgia Ph.D. Molecular Genetics (Zoology) 1975 California Institute of Technology Postdoctoral Biology 1975-1980

HONORS

Merck Chemistry Prize, Department of Chemistry,University of Georgia, 1972; Phi Beta Kappa, University of Georgia, 1972; summa cum laude, University of Georgia, 1972; Graduate Research Fellow, University of Georgia, 1972-1975; NIH/NRSA Fellowship, 1975-1978; American Cancer Society Lievere Fellowship, 1978-1980.

RESEARCH AND PROFESSIONAL EXPERIENCE

Graduate Research Fellow, University of Georgia, 1972-1975; Research Fellow, Division of Biology, California Institute of Technology, 1976-1980; Senior Research Fellow, Division of Biology, California Institute of Technology, 1980-1982; Assistant Professor, Biology Department, Texas A&M University, 1983-1988; Associate Professor, Biology Department, Texas A&M University, 1988-1992; Professor, Biology Department, Texas A&M University, 1992-present; Professor and Interim Head, Biology Department, Texas A&M University, 1992-1994; Professor and Head, Biology Department, Texas A&M University, 1994-2002; Member, NIH Study Section, 1992-1996. DOE Energy Biosciences Review Panel, 1997. Director, Laboratory for Functional Genomics, 1999-present; Consultant and Scientific Advisor for Bayer Crop Science (formerly Aventis Crop Science) and RhoBio/Biogemma, 1999-2010; USDA Plant Genetic Mechanisms Review Panel, 2002-2004. Editorial Review Board, Environmental Health Perspectives: Toxicogenomics, 2002-2005; Consultant and Scientific Advisor for Alpha Biolaboratory, Inc. 2005-present.

PUBLICATIONS

1. Leyden, D.E., T.L. Thomas, S.M. Guill and C.W. Blount. 1973. Application of chelating ionexchange resins for trace element analysis for geological samples using x-ray fluorescence.Analytical Chemistry 45:1945-1954.

2. Patel, G.L. and T.L. Thomas. 1973. Some binding parameters of chromatin acidic proteins withhigh affinity for deoxyribonucleic acid. Proc. Natl. Acad. Sci. USA 70:2524-2529.

3. Thomas, T.L. and G.L. Patel. 1976. Optimal conditions and specificity of interactions of a distinctclass of nonhistone chromosomal proteins with DNA. Biochemistry 15:1481-1489.

4. Thomas, T.L. and G.L. Patel. 1976. DNA unwinding component of the nonhistone chromatinproteins. Proc. Natl. Acad. Sci. USA 73:4364-4368.

5. Scheller, R.H., T.L. Thomas, A.S. Lee, W.H. Klein, W.D. Niles, R.J. Britten and E.H. Davidson.1977. Clones of individual repetitive sequences from sea urchin DNA constructed with syntheticEcoRI sites. Science 196:197-200.

6. Klein, W.H., T.L. Thomas, C. Lai, R.H. Scheller, R.J. Britten and E.H. Davidson. 1978.Characteristics of individual repetitive sequence families in the sea urchin genome studied withcloned repeats. Cell 14:889-900.

7. Lev, Z., T.L. Thomas, A.S. Lee, R.C. Angerer, R.J. Britten and E.H. Davidson. 1980.Developmental expression of two cloned sequences coding for rare sea urchin embryo messages.Developmental Biology 76:322-340.

8. Lee, A.S., T.L. Thomas, Z. Lev, R.J. Britten and E.H.Davidson. 1980. Four sizes of transcriptproduced by a single sea urchin gene expressed in early embryos. Proc. Natl. Acad. Sci. USA. 77:3259-3263.

9. Scheller, R.H., L.B. McAllister, W.R. Crain, D.S. Durica, J.W. Posakony, T.L. Thomas, R.J.Britten and E.H. Davidson. 1981. Organization and expression of multiple actin genes in the seaurchin. Molecular and Cellular Biology 1:609-628.

10. Thomas, T.L., J.W. Posakony, D.M. Anderson, R.J. Britten and E.H. Davidson. 1981. Molecularstructure of maternal RNA. Chromosoma 84:319-335.

11. Davidson, E.H., T.L. Thomas, R.H. Scheller and R.J. Britten. 1982. The sea urchin actin genesand a speculation on the evolutionary significance of small gene families. In Genome Evolution,G. Dover and R.B. Flavell (eds.). Academic Press, London, pp 177-191.

12. Thomas, T.L., R.J. Britten and E.H. Davidson. 1982. An interspersed region of the sea urchingenome represented in both maternal Poly (A)RNA and embryo nuclear RNA. DevelopmentalBiology 94:230-239.

13. Davidson, E.H., H. T. Jacobs, T. L. Thomas, B.R. Hough-Evans and R.J. Britten. 1983. Poly (A)RNA of the egg cytoplasm: structural resemblance to the nuclear RNA of somatic cells. CibaFoundation Symp 98:6-24.

14. Lee, J.J., R.J. Shott, S.J. Rose, T.L. Thomas, R.J. Britten and E.H. Davidson. 1984. Sea urchinactin gene subtypes: Gene number, linkage and evolution. J. Mol. Biol 172:149-176.

15. Allen, R.D., C.L. Nessler and T.L. Thomas. 1985. Developmental expression of the sunflower11S storage protein gene. Plant Molecular Biology 5:165-173.

16. Thomas, T.L. and D. Wilde. 1985. Analysis of gene expression in carrot somatic embryos. InSomatic Embryogenesis, M. Terzi, M. Pitto and Z.R. Sung (eds.). IPRA, Rome, pp 77-85.

17. Thomas, T.L. and T.C. Hall. 1985. Gene transfer and expression in plants: Implications andpotential. Bioessays 3:149-143.

18. Allen, R.D., E.A. Cohen, R.A. Vonder Haar, K.A. Orth, D.P. Ma, C.L. Nessler and T.L. Thomas.1987. Expression of embryo specific genes in sunflower. In UCLA Symposium on MolecularApproaches to Developmental Biology, E. Davidson and R. Firtel (eds.). Alan R. Liss, New York,pp 415-424.

19. Thomas, T.L. and D. Wilde. 1987. Analysis of carrot somatic embryo gene expression programs.Plant Tissue and Cell Culture, C. Green, D. Somers, W. Hackett and D. Biesboer (eds.). Alan R.Liss, New York, pp 83-93.

20. Allen, R.D., E.A. Cohen, R.C. Vonder Haar, C.A. Adams, C.L. Nessler and T.L. Thomas. 1987.Sequence and expression of a gene encoding an albumin storage protein in sunflower. MolecularGen. Genet. 210:211-218.

21. Hall, T.C. and T.L. Thomas. 1987. Molecular approaches for the manipulation of developmentalprocesses in plants. In Hormone Action in Plant Development- A Critical Appraisal, R. Atkin(ed.). Proceedings of the 10th Long Ashton Symposium, pp 287-297.

22. Durica, D.S., M.A. Restrepo, T.L. Thomas and K.M. Beckingham. 1987. Isolation andcharacterization of abl gene sequences in Calliphora erythrocephala. Gene 59:63-76.

23. Adams, C.A., K.E. Koprivnikar, R.D. Allen, E.A. Cohen, C.L. Nessler and T.L. Thomas. 1988.Regulation of gene expression in sunflower embryos. In Biotechnology in Crop Protection, P.Hedin, J. Menn and R. Hollingworth (eds.). American Chemical Society Symposium Series,ACS Books, Washington, pp 240-247.

24. Allen, R.D., R.N. Trelease and T.L. Thomas. 1988. Regulation of isocitrate lyase gene expressionin sunflower. Plant Physiology 86:527-532.

25. De Vries S., H. Booij, P. Meyerink, G. Huisman, M. van Spanje, H.D. Wilde, T.L. Thomas andA. van Kammen. 1988. Acquisition of embryogenic potential in carrot cell suspension cultures.Planta 176:196-204.

26. Wilde, H.D., W.S. Nelson, H. Booij, S. de Vries and T.L. Thomas. 1988. Gene expressionprograms in embryogenic carrot cultures. Planta 176:205-211.

27. Vonder Haar, R.A., R.D. Allen, E.A. Cohen, C.L. Nessler and T.L. Thomas. 1988. Organizationof the sunflower 11S storage protein gene family. Gene 74:433-443.

28. Adkinson, L.R., L.C. Skow, T.L. Thomas, M. Petrash and J.E. Womack. 1988. Somatic cellmapping and restriction fragment analysis of bovine genes for fibronectin and gamma crystallin.Cytogenetic Cell Genetics 47:155-159.

29. Moyer, S.P., D.P. Ma, T.L. Thomas and J.R. Gold. 1988. Characterization of a highly repeatedsatellite DNA from the cyprinid fish Notropis lutrensis. Comp. Bioch. Physiol. 91:639-646.

30. Jordano, J.J., C. Almoguera and T.L. Thomas. 1989. A sunflower helianthinin gene upstreamsequence ensemble contains an enhancer and sites of nuclear protein interaction. The Plant Cell1: 855-866.

31. Dure, L., M. Crouch, J. Harada, T.D. Ho, J. Mundy, R. Quatrano, T. Thomas and Z.R. Sung.1989. Common amino acid sequence domains among the lea proteins of higher plants. PlantMol. Biol. 12:475-486.

32. Guiltinan M.J., J.C. Thomas, C.L. Nessler and T.L. Thomas. 1989. Expression of DNA bindingproteins in carrot somatic embryos that specifically interact with a cis regulatory element of theFrench bean phaseolin gene. Plant Mol. Biol. 13:605-610.

33. Thomas, J.C., M.J. Guiltinan, S. Bustos, T. L. Thomas and C. Nessler. 1989. Carrot (Daucuscarota) hypocotyl transformation using Agrobacterium tumefaciens. Plant Cell Rep. 8:354-357.

34. Seffens, W.S., C. Almoguera, H.D. Wilde and T.L. Thomas. 1990. Molecular analysis of aphylogenetically conserved carrot gene: Developmental and environmental control. Dev. Genet.11:65-76.

35. Bogue, M., M. Nuccio, R. Vonder Haar, L. Griffing and T.L. Thomas. 1990. Developmentallyregulated expression of a sunflower 11S seed protein gene in transgenic tobacco. Mol. Gen.Genet. 222:49-57.

36. Thomas, T.L., J. Vivekananda and M. Bogue. 1991. ABA regulation of gene expression inembryos and mature plants. In Topics in Environmental Physiology, W.J. Davies (ed), BIOS,London, pp 125-135.

37. Adams, C.A., W.S. Nelson, A.N. Nunberg and T.L. Thomas. 1992. A wound-inducible memberof the HRGP gene family in sunflower. Plant Physiology 99:775-776.

38. Vivekananda, J., M.C. Drew and T.L. Thomas. 1992. Hormonal and environmental regulation ofthe carrot lea-class gene Dc3. Plant Physiology,100:576-581.

39. Reddy, A.S., Nuccio, M.L., Gross, L.M. and Thomas T.L. 1993. Isolation of a ∆6-desaturasegene from the cyanobacterium Synechocystis sp. strain PCC 6803 by gain-of-function expressionin Anabaena sp. strain PCC 7120. Plant Molecular Biology, 22:293-300.

40. Thomas, T.L. 1993. Gene expression during embryogenesis and germination: an overview. ThePlant Cell, 5, 1401-1410.

41. Nunberg, A.N. and Thomas, T.L 1993. Transient analysis of gene expression in plant cells. InMethods in Plant Molecular Biology and Biotechnology. B.R. Glick and J.E. Thompson (eds.),CRC Press, Boca Raton, pp 147-154.

42. Van Engelen, F.A., Hartog, M., Thomas, T.L., Taylor, B., Sturm, A., van Kammen, A. and deVries, S.C. 1993. The carrot secreted glycoprotein gene EP1 is expressed in the epidermis andhas sequence homology to Brassica S-locus glycoproteins. The Plant Journal, 4, 855-862.

43. Reddy, A.S., Nuccio, M.L, Gross, L.M., Freyssinet, M. and Thomas, T.L. 1993. Cloning andexpression of a cyanobacterial ∆6-desaturase. Grasas Y Aceites, 44, 123-124.

44. Nunberg, A.N., Li, Z., Bogue, M.A., Vivekananda, J., Reddy, A.S. and Thomas, T.L. 1994Developmental and hormonal regulation of sunflower helianthinin genes: A proximal promoterconfers regionalized seed expression. The Plant Cell, 6: 473-486.

45. Wilde, H.D., Seffens, W. S. and Thomas, T.L. 1994. Gene expression in somatic embryos. InBiotechnology in Agriculture and Forestry, Vol. 30 Somatic Embryogenesis and Synthetic SeedsI, (ed. YPS Bajaj), Springer Verlag, New York, pp 43-54.

46. Nunberg, A.N., Li, Z., Chung, H.-J., Reddy, A.S. and Thomas, T.L. 1995. Proximal promotersequences of sunflower helianthinin genes confer regionalized seed-specific expression. J. PlantPhys. 145:600-605.

47. Frisch, D.A., Harris-Haller, L., Yokubaitis, N.T., Thomas, T.L., Hardin, S. and Hall, T. C. 1995.Complete sequence of the binary vector BIN 19. Plant Mol. Biol. 27: 405-409.

48. Reddy, A.S., and Thomas,T.L. 1996. Modification of plant lipid composition: Expression of acyanobacterial ∆6-desaturase gene in transgenic plants. Nature BioTechnology 14: 639-642.

49. Frugoli, J.A., Zhong, H.H., Nuccio, M.L., McCourt, P., McPeek, M.A., Thomas, T.L. andMcClung, C.R. 1996. Catalase is encoded by a multi-gene family in Arabidopsis thaliana (L.)Heynh. Plant Physiol. 112: 327-336.

50. Nunberg, A.N., Li, Z. and T. L. Thomas. 1996. “Analysis of Gene Expression and Gene Isolationby High-Throughput Sequencing of Plant cDNAs” in Genome Mapping in Plants, (ed. A.Paterson), Landes Biomedical Press, Austin. pp 171-179.

51. Coca, M. A., Almoguera, C., Thomas, T.L., and Jordano, J. 1996. Differential regulation of smallheat-shock genes in plants: Analysis of a singular water-stress-inducible and developmentallyactivated sunflower promoter. Plant Mol. Biol. 31:863-876.

52. Vielle, J.P., Nuccio, M.L., Thomas, T.L., Hussey, M.A. and Wing, R. L. 1996. Comparativegene expression in sexual and apomictic ovaries of Pennisetum ciliare (L.) Link., Plant Mol. Biol.32: 1085-1092.

53. Thomas, T.L., Chung, H.-J. and Nunberg, A.N. 1997 “ABA mediated signal transduction” inSignal Transduction in Plants (ed. P. Aducci), Birkäuser-Verlag AG, Basel. pp 23-43.

54. Beremand, P.D., Nunberg, A.N., Reddy, A.S., and Thomas, T.L. 1997. “Production of γ-linolenicacid by transgenic plants expressing cyanobacterial or plant ∆6-desaturase genes” in Physiology,Biochemistry and Molecular Biology of Plant Lipids, (eds J.P. Williams, K.U. Mobashsher,N.W. Lem), Kluwer Academic Publishers, Dordrecht, pp 31-353.

55. Kim, S. Y., Chung, H.-J. and T.L. Thomas. 1997. Isolation of a novel class of bZIP transcriptionfactors that interact with ABA-responsive and embryo-specification elements in the Dc3promoter using a modified yeast one-hybrid cloning system. Plant Journal., 11: 1237-1251.

56. Nuccio, M.L., Li, Z., Hsieh, T.F. and Thomas, T.L. 1997. Molecular approaches to identifynovel genes expressed in Arabidopsis. SAAS Bulletin/ Biochem & Biotech, 10, 7-11.

57. Ivy, J.M., Beremand, P.D. and Thomas, T.L. 1998. Strategies for modifying fatty acidcomposition in transgenic plants. Biotechnology and Genetic Engineering Reviews. 15, 271-288.

58. Li, Zhongsen and Thomas, T. L. 1998. PEI1, an embryo-specific zinc finger protein generequired for heart-stage embryo formation in Arabidopsis. Plant Cell, 10:383-398.

59. Kim, S.Y. and Thomas, T.L. 1998. A family of basic leucine zipper proteins binds to seedspecification elements in the carrot Dc3 gene promoter. J. Plant Phys. 152: 607-613.

60. Frugoli, J.A., McPeek, M.A., Thomas, T.L. and McClung, C.R. 1998. Intron loss and gainduring evolution of the catalase gene family in angiosperms. Genetics, 149: 355-365.

61. Siddiqui, N.U., Chung, H.-J., Thomas, T.L. and Drew, M.C. 1998.Abscisic acid-dependent and -independent expression of carrot LEA-class gene Dc3 in transgenic tobacco seedlings. Plant Phys.118: 1181-1190.

62. Freyssinet, G and Thomas, T. 1998. Plants as a factory to produce molecules. Pure & Appl.Chem. 70: 61-66.

63. Nuccio, M.L.and Thomas, T.L. 1999. ATS1 and ATS3: Two novel embryo-specific genes inArabidopsis thaliana. Plant Mol. Biol., 39: 1153-1163.

64. Nuccio, M.L., Hsieh, T.F. and Thomas T.L. 2000. “The use of RT-PCR differentialdisplay in single-celled organisms and plant tissues.” in Differential Display: A Practical

Approach. (eds R. Leslie and H. Robertson),Oxford University Press, Oxford, pp 83-99.

65. Chak, R.K.F., Thomas, T. L., Quatrano, R.S., and Rock, C.R. 2000. The genes ABI1 and ABI2are involved in abscisic acid- and drought inducible expression of Daucus carota L. Dc3promoter in guard cells of transgenic Arabidopsis thaliana (L.) Heynh. Planta 210, 875-883.

66. Chen, I., Hsieh, T., Thomas, T.L. and Safe, S. 2001. Identification of estrogen-induced genesdownregulated by AhR agonists in MCF-7 breast cancer cells using suppression subtractivehybridization. Gene, 262, 207-214.

67. Mu, X., Zhao, S., Pershad, R., Hsieh, T.-F., Scarpa, A., Wang, S.W., White, A., Beremand, P.D.,Thomas, T. L., Gan, L. and Klein, W.H. 2001. Gene expression in the developing mouse retina byEST sequencing and microarray analysis. Nucleic Acids Research, 29, 4983-4993.

68. Qui, X., Hong, H., Datla, N., MacKenzie, S.L., Taylor, D.C., and Thomas, T.L. 2002. Expressionof borage ∆6-desaturase in Saccharomyces cerevisiae and oilseed crops. Canadian Journal ofBotany 80, 42-49.

69. Duval, M., Hsieh, T.F., Kim, S.Y. and Thomas, T.L. 2002. Molecular characterization of AtNAM:A member of the Arabidopsis NAC domain superfamily. Plant Molecular Biology, 50: 237-248.

70. Chuang, H.-W.,Hsieh, T.-F., Duval, M and Thomas, T.L. 2002. Genomic analysis of Arabidopsisgene expression in response to a systemic fungicide. In Genomics of Plants and Fungi, (eds. R.A.Prade and H.J.Bohnert), Marcel Dekker, Inc., New York. pp 237-253.

71. Lewis, Z.A., Correa, A., Schwerdtfeger, C., Link, K.L., Xie, X., Gomer, R.H., Thomas, T.,Ebbole, D.J. and Bell-Pedersen, D. 2002. Overexpression of WHITE COLLAR-1(WC-1)activates circadian clock-associated genes, but is not sufficient to induce light-regulated geneexpression in Neurospora crassa. Molecular Microbiology, 45: 917-931.

72. Kim, S.Y., Ma, J., Perret, P., Li, Z. and Thomas, T.L. 2002. Arabidopsis ABI5 subfamilymembers have distinct DNA-binding and transcriptional activities. Plant Physiol., 130: 688-697.

73. Bailey, M.J., Beremand, P.D., Hammer, R., Bell-Pedersen, D., Thomas, T.L. and Cassone, V.M.(2003) Transcriptional profiling of the chick pineal gland, a photoreceptive circadian oscillatorand pacemaker. Molecular Endocrinology 17, 2084-2095.

74. Mu, X., Beremand, P.D., Zhao, S., Pershad, R., Sun, H., Scarpa, A., Liang, S., Thomas,T.L., Klein, W.H. (2003) Discrete gene sets depend on POU transcription factorBrn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina. Development131, 1197-1210.

75. Bailey, M.J., Beremand, P., Hammer, R., Reidel, E., Thomas, T.L. and Cassone, V.M.2004. Transcriptional profiling of circadian patterns of mRNA expression in the chickretina. J. Biol. Chem. 279, 52247-52254.

76. Liang, S., Zhao, S., Mu., X., Thomas, T. L. and Klein, W.H. Novel retinal genesdiscovered by mining the mouse embryonic RetinalExpress database. 2004. MolecularVision, 10, 773-786.

77. Ebbole, D.J., Yuan, J., Thon, M., Pan, H., Bhatterai, E., Thomas, T. and Dean, R. 2004.Gene discovery and gene expression in the rice blast fungus, Magnaporthe grisea:Analysis of expressed sequence tags. Molecular Plant-Microbe Interactions. 17, 1337-1347.

78. Chung, H.J., Fu, H. Y. and Thomas, T.L. 2005. ABA inducible nuclear proteins bind tobipartite promoter elements required for ABA response and embryo regulated expressionof the carrot Dc3 gene. Planta, 220, 424-433.

79. Mu, X., Fu,X., Sun, H., Beremand, P.D., Thomas, T.L., and Klein, W.H. 2005. A GeneNetwork Downstream Of Transcription Factor Math5 Regulates Retinal Progenitor CellCompetence And Ganglion Cell Fate. Developmental Biology, 280, 467-481.

80. Holtman C.K., Chen, Y, Sandoval, P., Gonzales, A., Nalty, M.S., Thomas, T.L.,Youderian, P., and Golden, SS. 2005. High-throughput functional analysis of theSynechococcus elongatus PCC 7942 genome. DNA Research, 12, 103-115.

81. Menger, G.J., Lu, K., Thomas, T.L., Cassone, V.M., Earnest, D.J. 2005. Circadianprofiling of the transcriptome on immortalized rat SCN cells. Physiological Genomics,21, 370 - 381.

82. Bell-Pedersen, D., Cassone, V.M., Earnest, D.J., Golden, S.S., Hardin, P.E., Thomas,T.L., and Zoran, M.J. 2005. The regulation of circadian rhythmicity by multipleoscillators: lessons from diverse organisms. Nature Reviews Genetics, 6, 544-556.

83. Finkelstein, R., Gampala, S., Lynch, T., Thomas, T. and Rock, C. 2005. Redundant and distinctfunctions of the ABA response loci ABA-INSENSITIVE(ABI)5 and ABRE-BINDINGFACTOR(ABF)3. Plant Molecular Biology, 59, 253-267.

84. Gray, C.A., Abbery, C.A., Beremand, P.D., Choi, Y., Farmer, J.L., Adelson, D.L., Thomas, T.L.,Bazer, F.W., Spencer, T.E. 2006. Transcriptional profiling of endometrial responses to earlypregnancy in sheep. Biology of Reproduction, 74,383-394.

85. Menger, G., Allen, G., Neuendorff, N., Nahm, S.-S., Thomas, T., Cassone, V., Earnest, D. 2007.Circadian Profiling of the Transcriptome in NIH/3T3 Fibroblasts: Comparison with RhythmicGene Expression in SCN2.2 Cells and the Rat SCN. Physiological Genomics, 29. 280-289.

86. Roux, C., Rolan, H., Santos, R.,Beremand, P.,Thomas, T., Adams, L., Tsolis, R. 2007. Brucellarequires a functional Type IV secretion system to elicit innate immune responses in mice.Cellular Microbiology, 9, 1851-1869.

87. Mu, X., Fu, X., Beremand, P.D., Thomas, T.L. and Klein, W.H. 2008 Gene regulation logic inretinal ganglion cell development: Isl1 defines a critical branch distinct from but overlappingwith Pou4f2. Proc. Natl. Acad. Sci., 105, 6942-6947.

88. Karaganis, S.P., Kumar, V., Beremand, P.D., Bailey, M.J., Thomas, T.L. and Cassone, V.M.2008. Circadian genomics of the chick pineal gland in vitro. BMC Genomics 9, 206-223.

89. Damaj MB, Beremand PD, Buenrostro-Nava MT, Riedel B, Molina JJ, Kumpatla SP, ThomasTL, Mirkov TE (2009) Reproducible RNA preparation from sugarcane and citrus for functionalgenomic applications. Int J Plant Genomics. 2009;2009:765367. Epub 2010 Jan 27

90. Damaj, MB, Kumpatla, SP, Emani, C, Beremand, PB, Avutu S. Reddy, AS, Rathore, KS, Curtis,Thomas, TL and Mirkov, TE (2010) Sugarcane DIRIGENT and O-METHYLTRANSFERASEpromoters confer stem-expressed gene expression in diverse monocots. Planta, 231, 1439-1458.

91. Smith, K.M, Sancar, G., Dekhang, R., Sullivan, C.M., Lie, S., Tag, A.G., Sancar, C., BredewegE. L., Priest, H.D., McCormick, R.F., Thomas, T.L., Carrington, J.C., Stajich, J.E., Bell-Pedersen, D., Brunner, M. and Freitag, M. Transcription factors in light and circadian clocksignaling networks revealed by genome-wide mapping of direct targets for Neurospora WHITECOLLAR COMPLEX. 2010 . Eukaryot. Cell 9: 1549 – 1556.

92. Alvarado, VY, Tag, A and Thomas, TL (2011) A cis regulatory element in the TAPNAC promoterdirects tapetal gene expression. Plant Mol Biol 75: 129-139.

93. Bennett, L.D., Beremand, P., Thomas, T.L. and Bell-Pedersen, D. (2013) Circadian activation ofthe mitogen-activated protein kinase MAK-1 facilitates rhythms in clock-controlled genes inNeurospora crassa, Eukaryot Cell 12: 59-69.

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors.


NAME Evelyn Tiffany-Castiglioni

POSITION TITLE Professor & Head, Dept. Vet. Integrat. Biosci. Assoc. Dean for Undergraduate Education eRA COMMONS USER NAME

ecastiglioni EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)


University of Texas-El Paso B.S. 1975 Biology University of Texas-Galveston Ph.D. 1979 Hum. Genet. & Cell Biol. University of California at Los Angeles Postdoc 1980-1982 Develop. Neurobiol.

Personal Statement. My laboratory carries out research on mechanisms of neurotoxicity of environmental contaminants, including metals and pesticides. I am the editor and co-author of In Vitro Toxicology: Principles and Challenges (Humana Press, 2004), which is being revised and updated currently for release in 2016 (Springer). I have served as major professor for 18 graduate students in toxicology and neuroscience, most of whom are now productive scientists in academia, government, or industry.


Positions and Employment: 1982-1987 Assistant Professor, Texas A&M University 1987-1994 Associate Professor, Texas A&M University 1989-1990 Visiting Associate, Professor University of Texas Health Science Center, San Antonio 1990-present Faculty of Neuroscience and Faculty of Toxicology, Texas A&M University 1994-present Professor, Texas A&M University 1996-1998 Asst. Dean for Undergraduate Education, Texas A&M University 1998-present Assoc. Dean for Undergraduate Education, Texas A&M University 1998-1999 Interim Department Head, Texas A&M University, Vet. Anatomy & Public Health 1999-present Department Head, Texas A&M University, Vet. Integrative Biosciences (dept. renamed 2004)

Other Experience and Professional Service (last 6 years): Editorial Board of International Journal of Developmental Neuroscience, 2000-present Associate Editor, Neurotoxicology, 2004-present External Advisory Committee for NIH Superfund Program application entitled “Superfund Metal Mixtures,

Biomarkers and Neurodevelopment,” Harvard School of Public Health, 2008-present. National Science Foundation review panel for Graduate Research Fellowships Program, 2009, 2014 NIOSH Disease, Disability and Injury Prevention and Control Special Emphasis Panel ZOH1 EEO (50),

teleconference meetings November 15, 2010, June 16, 2011, and March 5, 2013. Member, Scientific Steering Committee of the International Conference on Alternatives for Developmental

Neurotoxicity Conference, DNT3, Italy, 11-13 May 2011, 2009-2011. NIOSH SOH Study Section ad hoc member, February 21-23, 2012; February 19-21, 2013, October 2013,

February 2015; NIOSH SOH Member Conflict Reviewer, October 28, 2014 NORA Study Section ad hoc member, February 21, 2013, February 20, 2015 NIOSH WTC Study Section ad hoc member, February 21-22, 2013, March 31- April 2, 2014

B. 15Selected peer-reviewed publications (from 84 peer-reviewed publications and 15 book chapters)Barhoumi, R., R.C. Burghardt, Y. Qian, E. Tiffany-Castiglioni. 2007. Effects of propofol on intracellular Ca2+

homeostasis in human astrocytoma cells. Brain Research 1145:11-18. Qian, Y., J.S. Venkatraj, R. Barhoumi, R. Pal, A. Datta, J.R. Wild, E. Tiffany-Castiglioni. 2007. Comparative

non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) on human neuroblastoma and astrocytoma cell lines. Toxicol. App. Pharm. 219:162-171.

Qian, Y., Y. Zheng, D. Weber, E. Tiffany-Castiglioni. 2007. A 78-kDa glucose-regulated protein is involved in the decrease of interleukin-6 secretion by lead treatment from astrocytes. Am. J. Physiol. [Cell Physiol.] 293:897-905.

White, L.D., D.A. Cory-Slechta, M.E. Gilbert, E. Tiffany-Castiglioni, N.H. Zawia, M. Virgolini, A. Rossi-George, S.M. Lasley, Y. Qian, M.R. Basha. 2007. New and evolving concepts in the neurotoxicology of lead.Toxicol. App. Pharm. 225:1-27.

Yang, W., E. Tiffany-Castiglioni. 2007. The bipyridyl herbicide paraquat induces proteasome dysfunction in human neuroblastoma SH-SY5Y cells. J.Tox. Env. Health A 70:1849-1857.

Yang, W., E. Tiffany-Castiglioni. 2008. Paraquat-induced apoptosis in human neuroblastoma SH-SY5Y cells: involvement of p53 and mitochondria. J Toxicol Environ Health A 71(4): 289-99.

Qian, Y., Y. Zheng, E. Tiffany-Castiglioni. 2009. Valproate reversibly reduces neurite outgrowth by human SY5Y neuroblastoma cells. Brain Research 1302:21-33.

Yang, W., E. Tiffany-Castiglioni, H. C. Koh, I.-H. Son. 2009. Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cells. Toxicology Letters 191:203-210.

Barhoumi, R., Y. Qian, R. Burghardt, and E. Tiffany-Castiglioni. 2010. Image analysis of Ca2+ signals as a basis for neurotoxicity assays: Promises and challenges. Neurotoxicology and Teratology 32:1, 16-24.

Yang, W., E. Tiffany-Castiglioni, M.-Y. Li, I.-H. Son. 2010. Paraquat induces cyclooxygenase-2 (COX-2) implicated toxicity in human neuroblastoma SH-SY5Y cells. Toxicology Letters 199:239-246.

Watanabe, K.H., M.E. Andersen, N. Basu, M.J. Carvan III, K.M. Crofton, K.A. King, C. Suñol, E. Tiffany-Castiglioni, I.R. Schultz. 2011. Defining and modeling known adverse outcome pathways: Domoic acid and neuronal signaling as a case study. Environmental Toxicology and Chemistry 30:9-21.

Tiffany-Castiglioni, E., S. Hong, Y. Qian. 2011. Copper handling by astrocytes: Insights into neurodegenerative diseases. International Journal of Developmental Neuroscience 29: 811-818.

Qian, Y., Y. Zheng, R. Taylor, E. Tiffany-Castiglioni. 2012. Involvement of molecular chaperone Hspa5 in copper homeostasis in astrocytes. Brain Research 1447:9-19.

Tiffany-Castiglioni. E. , Y. Qian. 2012. ER chaperone-metal interactions: links to protein folding disorders. Neurotoxicology 33:545-557.

Qian, Y., B. Meng, X. Zhang, Y. Zheng, Ying, R. Taylor, E. Tiffany-Castiglioni. 2013. HSPA5 forms specific complexes with copper. Neurochem. Research 38:321-329 .

C. Research Support and External Grants (Completed last 10 years)Rising to the Challenge Scholarship Program 07/01/08-06/30/09Greater Texas FoundationThis grant provided scholarships for underrepresented 2+2 transfer students matriculating into the BiomedicalSciences program at Texas A&M UniversityRole: PI

T32-ES07273 Safe (PI) 07/01/02-06/30/07 NIEHS Toxicology of Environmental Contaminants This was a toxicology training grant supporting six graduate research assistants and one postdoctoral fellow. Role: Co-Investigator and seminar coordinator

P30 ES09106-01 Safe (PI) 05/01/01-04/31/07 NIEHS Center for Environmental and Rural Health (CERH) The overall goal of the CERH was to foster and promote basic and applied science programs focusing on the impact of environmental factors on human health, particularly as it relates to rural communities. Role: Investigator

P42 ES049171 Safe (PI) 04/01/00 - 03/31/05 NIEHS Procedures to Assess the Hazards of a Superfund Site Project 3: Stress Gene Induction in Mammalian Cells (Kenneth Ramos, PI) The goal of this project was to assess the toxicity of metals on chaperone function. Role: Co-Investigator

Victor M. Ugaz Professional Preparation Degrees held University of Texas (Austin, TX) Aerospace Engineering B.S., 1991 University of Texas (Austin, TX) Aerospace Engineering M.S., 1994 Northwestern University (Evanston, IL) Chemical Engineering Ph.D., 1999 Postdoctoral research University of Michigan (Ann Arbor, MI), Microfabricated DNA analysis systems, 1999-2002. Appointments Professor, Dept. of Chemical Engineering, Texas A&M University, 2014-present. Associate Professor, Dept. of Chemical Engineering, Texas A&M University, 2008-present. Assistant Professor, Dept. of Chemical Engineering, Texas A&M University, 2003-2008. Products Most closely related to project: 1. Priye, A., Yu, Y., Hassan, Y.A., and Ugaz, V.M. “Synchronized Chaotic Targeting and

Acceleration of Surface Chemistry in Prebiotic Hydrothermal Microenvironments.” PNAS, 114 (2017): 1275-1280. Highlighted in C&E News [February 6, 2017].

2. Priye, A., Wong, S., Bi, Y., Carpio, M., Chang, J., Coen, M., Cope, D., Harris, J., Johnson, J., Keller, A., Lim, R., Lu, S., Millard, A., Pangelinan, A., Patel, N., Smith, L., Chan, K., and Ugaz, V.M. “Lab-on-a-Drone: Toward Pinpoint Deployment of Smartphone-enabled Nucleic Acid-based Diagnostics for Mobile Health Care.” Analytical Chemistry, 88 (2016): 4651-4660.

3. Meng, F. and Ugaz, V.M. “Instantaneous Physico-chemical Analysis of Suspension-based Nanomaterials.” Scientific Reports, 5 (2015): DOI:10.1038/srep09896.

4. Priye, A., Hassan, Y.A., and Ugaz, V.M. “Microscale Chaotic Advection Enables Robust Convective DNA Replication.” Analytical Chemistry, 85 (2013): 10536-10541.

5. Muddu, R., Hassan, Y.A., and Ugaz, V.M. “Chaotically Accelerated PCR by Microscale Rayleigh-Bénard Convection.” Angewandte Chemie International Edition, 50 (2011): 3048-3052.

Other significant publications: 1. Huang, J-H., Han, D., Ruggles, M.E., Jayaraman, A., and Ugaz, V.M. “Characterization of

Enzymatic Micromachining for Construction of Variable Cross-section Microchannel Topologies.” Biomicrofluidics, 10 (2016): 033101.

2. Shi, N. and Ugaz, V.M. “An Entropic Force Microscope Enables Nano-scale Conformational Probing of Biomolecules.” Small, 10 (2014): 2553-2557.

3. Meng, F., King, M.D., Hassan, Y.A., and Ugaz, V.M. “Localized Fluorescent Complexation Enables Rapid Monitoring of Airborne Nanoparticles.” Environmental Science: Nano, 1 (2014): 358-366.

4. Contreras-Naranjo, J.C. and Ugaz, V.M. “A Nanometer-scale Resolution Interference-based Probe of Interfacial Phenomena Between Microscopic Objects and Surfaces.” Nature Communications, 4 (2013): doi:10.1038/ncomms2865.

5. Huang, J-H., Jayaraman, A., and Ugaz, V.M. “Enzymatic Sculpting of Nano- and Micro-scale Surface Topographies.” Angewandte Chemie International Edition, 51 (2012): 9619-9623.

Synergistic Activities 1. Professional Service:

Editorial Board Member, Scientific Reports, 2017-present; Academic Editor, PLoS ONE, 2014-present; Deputy Editor, ELECTROPHORESIS, 2009-2014; AES Electrophoresis Society: President, 2008-2010; Newsletter Editor, 2012–present.

2. Departmental/University Service: Undergraduate Program Director and Associate Head, Dept. of Chemical Engineering 2013-2016, 2007-2009; Chair, TAMU Professional Program in Biotechnology, 2010-present; Co-advisor for Undergraduate Chem-E Car Team, 2006-2008.

3. Innovations in Teaching and Training: • Chemical Engineering Screencast YouTube channel:

http://www.youtube.com/user/vmugaz. • iPad-based Brownian dynamics simulation tool:

http://itunes.apple.com/us/app/brownian-dynamics/id922660798?ls=1&mt=8. • The Trailing Zone. Regular “perspectives” column published in the quarterly newsletter

of the American Electrophoresis Society (2012-present; http://www.aesociety.org/trailingzone/index.php).

4. Courses Taught: • Fluid Mechanics (CHEN 304; undergrad), Sp. 08, 09, 12, 13, Fa. 13, Sp. 14, 15, 16,

Fa. 15,16. • Foundations of Engineering II (ENGR 112; freshman level), Sp. 2011, Fa. 2011. • Heat Transfer (CHEN 323; undergrad), Sp. 2005, 2006, 2007, 2010. • Biotechnology Principles and Techniques II (BIOT 602), Sp. 2012, 2013. • Intro. to Polymer Engineering (CHEN 451/641; undergrad/grad), Fa. 2008, 2009, 2010. • Rheology (CHEN 640; grad), Fa. 2003, Su. 2007. • Introduction to Microfabrication and Microfluidics Technology (CHEN 489/689;

undergrad/grad), new course developed for Sp. 2004, Fa. 2005, 2006, 2007.

5. Teaching Accomplishments: Thaman University Professorship for Undergraduate Teaching Excellence (UPUTE), Texas A&M (awarded September, 2015). Association of Former Students Distinguished Teaching Award, Texas A&M (awarded April, 2013); Invited participant, the National Academy of Engineering’s 2012 Frontiers of Engineering Education (FOEE) Symposium, October 2012, Irvine, CA, Camille Dreyfus Teacher-Scholar Award, Camille and Henry Dreyfus Foundation (2008); Celanese Teaching Excellence Award, Texas A&M University, (awarded December, 2007); Tenneco Meritorious Teaching Award, Texas A&M (2007).

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors.


NAME Welsh, C. Jane

POSITION TITLE Professor, Veterinary Integrative Biosciences and Neuroscience Assistant Dean for Graduate Studies

eRA COMMONS USER NAME (credential, e.g., agency login) CJWelsh

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)


University of London, U.K. B.Sc. (Hons) 06/76 Microbiology University of London, U.K. Ph.D. 10/81 Immunology/Biochem. King’s College Hospital, U.K. Postdoc 1979-1981 Autoimmune liver Dept. of Pathology, Cambridge, U.K. Postdoc 1982-1985 Rheumatoid arthritis Dept. of Pathology, Cambridge, U.K. Postdoc 1985-1989 Multiple sclerosis

B. Positions and Honors POSITIONS 1988-‐1989 Special Supervisor in Pathology, Newnham College, Cambridge University 1989-‐ Visiting Assistant Professor (1989-‐1991), Assistant Professor (1991-‐2000); Associate Professor

(2000-‐2006), Professor (2006-‐present) Dept. of Veterinary Integrative Biosciences and Dept. of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University

1991-‐ Member of the Faculty of Neuroscience and Graduate Faculty, Texas A&M University 1998-‐ Member of the Genetics Faculty, Biotechnology Faculty and Executive Committee of the Faculty of

Virology, Texas A&M University 2002-‐ Departmental Graduate Advisor 2006-‐ Associate Department Head, Dept. Veterinary Integrative Biosciences 2007-‐ Joint appointments in the Dept. Neuroscience and Experimental Therapeutics, College of Medicine,

Texas A&M Health Science Center and Dept. Psychology, Texas A&M University 2011-‐ Chair of the Texas A&M Institute for Neuroscience 2011-‐ Assistant Dean for Graduate Studies, College of Veterinary Medicine HONORS AND ACTIVITIES 2001 Alzheimer’s Association Grant Reviewer 2003 Biotechnology and Biological Sciences Research Council, UK NIH Brain Disorders and Clinical Neuroscience Special Emphasis Panel (ZRG1-‐NMB) 2004 NSF Fellowship Review Panel, NMSS Pilot Grant Reviewer 2005 2008 & 2009 NSF Graduate Fellowship Review Panel 2006 NIH Brain Disorders and Clinical Neuroscience Special Emphasis Panel 2007 2008 2009 American Heart Association Grant Review Panel 2009 NIH Clinical Neuroimmunology and Brain Tumor Grant Review Panel 2010 NSF Grant Reviewer 2010 Texas A&M University’s (TAMU) Women’s Progress Award for faculty 2011 NIH P50 Reviewer 2011 TAMU Women’s Faculty Outstanding Mentoring Award 2012 TAMU Association of Former Students Distinguished Achievement Award for Graduate Mentoring 2013 Fast Forward MS Grant reviewer & 2013 Italian Multiple Sclerosis Society Editorial Board: Brain, Behavior and Immunity Ad hoc reviewer for: J. Infectious Diseases, Infection and Immunity, J. Virology, American Journal of Physiology: Heart and Circulation, Clinical and Diagnostic Laboratory Immunology, J. Neuroimmunology, Neuroimmunomodulation,

Brain Behavior and Immunity, PNAS, Neurotoxicology, Developmental Neuroscience, Neuropathology and Applied Neurobiology, Toxicology in Vitro, J. Neuroscience, Plos One C. Publications relevant to the current application Villarreal D, Young CR, Storts R, Ting JW & Welsh CJR (2006) A comparison of the neurotropism of Theiler’s virus and poliovirus in CBA mice. Microbial Pathogenesis, 41: 133-‐143. PMID 16935465

Mi W, Young CR, Storts R, Steelman A, Meagher MW & Welsh CJR (2006) Stress alters pathogenecity and facilitates systemic dissemination of Theiler’s virus. Microbial Pathogenesis 41: 149-‐156. PMID 16949789

Fuller, A, Yahikozawa, H, So EY, Dal Canto M, Koh CS, Welsh CJ & Kim BS (2007) Castration of male C57L/J mice increases susceptibility and estrogen treatment restores resistance to Theiler's virus-‐induced demyelinating disease. J Neurosci Res. 85: 871-‐881. PMID 17253641

Young EE, Prentice TW, Satterlee D, McCullough H, Sieve AN, Johnson RR, Welsh TH, Welsh CJR, & Meagher MW (2008) Glucocorticoid exposure alters the pathogenesis of Theiler's murine encephalomyelitis virus during acute infection. Physiology and Behavior 95: 63-‐71. PMID 18538803

Steelman AJ, Dean DD, Young CR, Smith R, Prentice TW, Meagher MW & Welsh CJR. (2009). Restraint stress modulates virus specific adaptive immunity during acute Theiler’s virus infection. Brain, Behavior and Immunity 23: 830-‐843. PMID 19348911

Welsh CJ, Steelman AJ, Mi W, Young CR, Dean DD, Storts R, Welsh TH, Meagher MW (2010). Effects of stress on the immune response to Theiler’s virus – implications for virus-‐induced autoimmunity. Neuroimmunomodulation. 17: 169-‐172.

Meagher MW, Sieve AN, Johnson RR, Satterlee D, Belyavskyi M, Mi W, Prentice T W, Welsh TH, & Welsh CJR (2010). Neonatal maternal separation disrupts viral clearance from the CNS during acute Theiler’s virus infection in adolescent mice. Behavior Genetics 40: 233-‐249. PMID 20135342

Vichaya EG, Young EE, Reusser NM, Cook JL, Steelman AJ, Welsh CJR, & Meagher MW (2011) Social Disruption Induced Priming of CNS Inflammatory Response to Theiler's Virus is Dependent upon Stress Induced IL-‐6 Release. J. Neuroimmunology, 239: 44-‐52. PMID 2200153

Rodrigues A, Welsh CJ, Varner P, Concha-‐Bermejillo A, Ambrus A, Edwards J (2012) Identification of the target cells and sequence of infection during experimental infection of ovine fetuses with Cache Valley virus. Journal of Virology, 86: 4793-‐4800. PMID 22379096

Young EE, Vichaya EG, Reusser, NM, Cook JL, Steelman AJ, Welsh CJR, Meagher MW (2013) Chronic social stress impairs virus specific adaptive immunity during acute Theiler’s virus infection. J. Neuroimmunology. 254, 19-‐27

Gomez FP, Steelman AJ, Young CR, Welsh CJ (2013) Hormones and immune system interactions in demyelinating diseases. Hormones and Behavior, 63: 315-‐321.

Rodrigues Hoffmann AF, Dorniak P, Filant J, Dunlap KA, Bazer FW, Concha-‐Bermejillo A, Welsh CJ, Varner P, Edwards JF. (2013) Ovine Fetal Immune Response to Cache Valley Virus Infection. J. Virol. 87: 5586-‐92

Steelman AJ, Smith R, Welsh CJ, Li J (2013) Galectin-‐9 is Up-‐regulated in Astrocytes by TNF and Promotes Encephalitogenic T-‐cell Apoptosis. J Biol. Chem. 288 (33): 23776-‐87.

Brinkmeyer-‐Langford C, Rodrigues A, Steelman AJ, Young CR, Meagher MW, Welsh CJR (2014) Consequences of perinatal bisphenol A exposure in a mouse model of multiple sclerosis. Autoimmunity 47, 57-‐66.

Johnson RR, Maldonado-‐Bouchard S, Prentice TW, Bridegam P, Fenan R, Young CR, Steelman AJ, Welsh TH, Welsh CJ, Meagher MW (2014) Neonatal experience interacts with adult social stress to alter acute and chronic Theiler's virus infection. In press Brain, Behavior and Immunity S0889-‐1591(14)00068-‐3. doi: 10.1016/j.bbi.2014.03.002. [Epub ahead of print].

Taylor A, Welsh CJR, Young CR, Spoor EM, Kerwin SC, Griffin JF, Levine GJ, Cohen ND, and Levine JM (2014) Cerebrospinal fluid inflammatory cytokines in naturally-‐occurring canine spinal cord injury. In press Journal of Neurotrauma.

D. Research Support Ongoing Research Support NIH/NINDS RO1 NS060822 12/01/2007-‐3/30/14 (includes two year no-‐cost extension) Mary Meagher (PI) Impact of stress-‐induced cytokines on an animal model of MS Goals: This grant examines the role of cytokines in mediating the adverse effects of social stress on Theiler’s virus infection. Role Co-‐PI



NAME

Westhusin, Mark E. POSITION TITLE

Professor eRA COMMONS USER NAME

mwesthusin EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)


Kansas State University B.S. 1980 Animal Science Texas A&M University M.S. 1983 Veterinary Physiology Texas A&M University Ph.D 1986 Veterinary Physiology A. Personal Statement.

I have been involved with the development and application of animal biotechnology and Assisted Reproductive Technologies (ARTs) for the past 30 years, and provided leadership for numerous research projects. My laboratory is best known for research involving animal cloning which resulted in our group cloning more different animal species than any other institution in the world, including the world’s first cat and first white-tailed deer. More recently my research focus has switched to improving the technology for producing transgenic livestock in which specific genes have been targeted for silencing by RNA interference. My laboratory group has already produced genetically modified offspring expressing transgenes encoding various shRNAs in sheep, pigs, goats and cattle. We have also successfully utilized RNAi to silence the expression of various genes involved with epigenetic reprogramming during preimplantation development in cattle, then determine the effects on development. More recently we have utilized TALENs and the CRISPR/Cas system to induce targeted mutations in genes critical for normal development. Over the course of my career I have served as chair or co-chair for 14 PhD students and 5 MS students. I have also served on the committees of numerous additional graduate students, mentored 5 postdoctoral fellows, and served as advisor for numerous undergraduate students conducting research in my lab. Given these and other experiences I am ideally suited to participate in the proposed project. B. Positions and Honors.

Positions and Employment January 1986 - December 1986. Farm Manager/Director of Research, International Cattle Embryos, Inc.

Mountain Home, AK. March 1987 - December 1991. Research Scientist, Granada Biosciences, College Station, TX July 1989 - April 1, 1992. Adjunct Professor, Department of Veterinary Physiology and Pharmacology, Texas

A&M University, College Station, TX. April 1, 1992 – August 31, 1998. Assistant Professor, Department of Veterinary Physiology and Pharmacology,

Texas A&M University, College Station, TX September 1, 1998 – April 2007. Associate Professor, Department of Veterinary Physiology and Pharmacology,

Texas A&M University, College Station, TX April 2007 – Present. Professor, Department of Veterinary Physiology and Pharmacology, Texas A&M

University, College Station, TX C. Selected peer-reviewed publications (selected from > 70 peer-reviewed publications). Most relevant to the current application 1. Shin T, Kraemer D, Pryor J, Liu L, Rugila J, Howe L, Buck S, Murphy K, Lyons L, Westhusin M. 2002.

A cat cloned by nuclear transplantation. Nature 415:859. 2. Golding MC, Long CR, Carmell MA, Hannon GJ, Westhusin ME. 2006. Suppression of prion protein in

livestock by RNA interference. Proc Natl Acad Sci. 14: 5285-5290. PCMID PMC1459347

3. Westhusin ME, Shin T, Templeton JW, Burghardt RC, Adams LG. 2007. Rescuing valuable genomes by animal cloning: a case for natural disease resistance. J. of Anim Sci. 85:138-142.

4. Tessanne K, Golding MC, Long C, Peoples M, Hannon G, Westhusin M. 2011. Production of transgenic calves expressing an effective shRNA targeting myostatin. Mol Reprod Dev. 3:176-85. PMCID: PMC3288734.

5. Cornetta K, Tessanne K, Long C, Yao J, Satterfield C, Westhusin M. 2013. Transgenic sheep generated by lentiviral vectors: safety and integration analysis of surrogates and their offspring. Transgenic Res. 4:737-745. PMCID: PMC3606283

Additional recent publications of importance to the field 1. Hill JR, Burghardt RC, Jones K, Long CR, Looney CR, Shin T, Spencer TE, Thompson JA, Winger QA,

Westhusin ME. 2000. Evidence for placental abnormality as the major cause of mortality in first-trimester somatic cell cloned bovine fetuses. Biol Reprod. 6:1787-1794.

2. Hill JR, Winger QA, Long CR, Looney CR, Thompson JA, Westhusin ME. 2000. Develpmental rates of male bovine nuclear transfer embryos derived from adult and fetal cells. Biol Reprod. 5:1135-1140.

3. Hill JR, Burghardt RC, Jones K, Long CR, Looney CR, Shin T, Spencer TE, Thompson JA, Winger QA, Westhusin ME. 2000. Evidence for placental abnormality as the major cause of mortality in first-trimester somatic cell cloned bovine fetuses. Biol Reprod. 6:1787-1794.

4. Jones KL, Hill J, Shin TY, Liu L, Westhusin M. 2001. Hypomethylation of karyoplasts for bovine nuclear transplantation. Mol Reprod Dev. 2:208-213.

5. Betts DH, Bordignon V, Hill JR, Winger Q, Westhusin ME, Smith LC, King WA. 2001. Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle. Proc Natl Acad Sci. 98:1077-1082. PCMID 2001 PMC14711.

6. Long CR, Walker SC, Tang RT, Westhusin ME. 2003. New commercial opportunities for advanced reproductive technologies in horses, wildlife, and companion animals. Therio 59:139-149.

7. Westhusin M, Hinrichs K, Choi YH, Shin T, Liu L, Kraemer D. 2003 Cloning Companion Animals (Horse, Cat, Dog). Cloning and Stem cells. 5:301-317.

8. Golding MC and Westhusin ME. 2003. Analysis of DNA (cytosine5) methyltransferase mRNA sequence and expression in bovine preimplantation embryos, fetal and adult tissues. 2003. Gene Expr Patterns 5:551-558.

9. Liu J, Westhusin M, Long C, Johnson G, Burghardt R, Kraemer D. 2010 Embryo production and possible species preservation by nuclear transfer of somatic cells isolated from bovine semen. Theriogenology 9:1629-1635.

10. Golding MC, Williamson GL, Stroud TK, Westhusin ME, Long CR. 2011. Examination of DNA methyltransferase expression in cloned embryos reveals an essential role for Dnmt1 in bovine development. Mol Reprod Dev. 5:306-317.

D. Research Support. (last 3 years)

Ongoing Research Support

1R24RR032683-01 Long (PI) 9/10/2011-7/31/2015 NIH- NCRR Inducible Tissue Specific Transgene Expression in Large Animal Biomedical Models The goal of this project is to produce a porcine model of human disease via tissue specific inducible expression of transgenes. Role: Co-PI 1RO1HD058969 NIH-NIHCD Westhusin (PI) 04/15/2010 - 02/28/2015 Functional Analysis of the Embryonic Epigenome in a Non-Rodent Model The major goals of this project are to characterize the expression and function of genes and proteins during early embryonic development in bovine embryos which are responsible for nuclear reprogramming and establishment of the epigenome e.g. DNA methyltransferases, Histone deacetylases and related proteins. Role: PI

K. L. Wooley, c.v. September 2016 1

KAREN L. WOOLEY W. T. Doherty-Welch Chair in Chemistry

University Distinguished Professor Texas A&M University, Department of Chemistry

3255 TAMU, P. O. Box 30012, College Station, Texas 77842-3012 Tel. (979) 845-4077, Fax (979) 862-1137, e-mail: [email protected]

www.chem.tamu.edu/faculty/wooley

Education: Ph. D., Cornell University, Polymer/Organic Chemistry, August 1993

Advisor: Professor J. M. J. Fréchet, Dissertation Title: "Design, Synthesis and Properties of Dendritic Macromolecules"

B. S., Oregon State University, Chemistry, May 1988

Professional History: Professor of Materials Science & Engineering, Texas A&M University, 2014 – present University Distinguished Professor, Texas A&M University, 2011 – present W. T. Doherty-Welch Chair in Chemistry; Professor of Chemistry; Professor of Chemical Engineering,

Texas A&M University, 2009 – present; Professor of Biotechnology Program, 2014 – present James S. McDonnell Distinguished University Professor of Arts & Sciences, Washington University, 2006 –

2009 Professor, Washington University, School of Arts & Sciences, Department of Chemistry, 1999 – 2009 Professor, Washington University, School of Medicine, Department of Radiology, 2007 – 2009 Faculty member in the Division of Biological and Biomedical Sciences, Chemical Biology Program,

Washington University, 1996 – 2005 Faculty member in the Center for Materials Innovation, Washington University, 2003 – 2009 Assistant Professor, Washington University, Department of Chemistry, August 1993 – 1999

Teaching: Texas A&M University. Chem466 Polymer Chemistry; Chem689 Special Topics: Nanomedicine Washington University. CH251 and CH252 Organic Chemistry; CH257 Organic Chemistry Laboratory;

CH358 Advanced Organic Chemistry Laboratory; CH452 Synthetic Polymer Chemistry; CH555 Special Topics in Organic Chemistry: Nanomedicine; Educ6009 Matter and Energy, an Outreach Course for K-8 Grade Teachers

Cornell University. Teaching Assistant for Organic Chemistry Laboratory Oregon State University. Teaching Assistant for General Chemistry Laboratory and Recitation

Honors/Awards:

Distinguished Achievement College-Level Teaching Award, Texas A&M University Association of Former Students, 2016

Peter Timms Lectureship, University of Bristol, 2016 National Science Foundation Distinguished Lecture in Mathematical and Physical Sciences, 2016 Melville Lectureship, University of Cambridge, 2016 Distinguished Research Achievement Award, Texas A&M University Association of Former Students, 2016 Dow Lecturer on Sustainable Chemistry, Colorado State University, 2016 Inaugural Aldrich Lecture, Tulane University, 2016 American Academy of Arts & Sciences Fellow, 2015 – present Oesper Award, University of Cincinnati, 2015 Ethel Ashworth-Tsutsui Memorial Lecture, Texas A&M University, 2015 College of Science Distinguished Lecture Series, Oregon State University, 2015


http://www.chem.tamu.edu/faculty/wooley


Reilly Lectureship, University of Notre Dame, 2015 Molecular Science Forum, Institute of Chemistry, the Chinese Academy of Sciences, Beijing, China, 2015 Honorary Fellow of the Chinese Chemical Society, 2014 – present Fellow of the Royal Society of Chemistry, 2014 – present Royal Society of Chemistry Centenary Prize, 2014 Texas A&M System Technology Commercialization Innovation Award, 2014 American Chemical Society Award in Polymer Chemistry, 2014 Oakridge High School Hall of Fame, 2013 National Institutes of Health NANO Study Section Chair, 2012-2014 Inaugural Featured Alumnus, Oregon State University, Department of Chemistry, Spring 2012 http://chemistry.oregonstate.edu/files/chem/OSU%20Chem%20Newsletter%20Spring%202012.pdf Milkovich Lecture Series, University of Akron, 2012 Lilly-Brown Lecture, Purdue University, 2011 Texas A&M University Distinguished Professor, 2011 – present Butler Lectureship Series, Center for Macromolecular Science & Engineering, University of Florida, 2010 Cheetham Lecture, Materials Research Outreach Symposium, University of California, Santa Barbara, 2010 Chevron-Phillips Lecture, Macromolecular Interfaces Institute, Virginia Tech, 2010 American Chemical Society, Polymer Chemistry Division, Founding POLY Fellow, 2010 W. T. Doherty-Welch Chair in Chemistry at Texas A&M University, 2009 – present American Chemical Society, Polymer Chemistry Division, Herman F. Mark Scholar Award, 2009 NSF Division of Materials Research, American Competitiveness and Innovation (ACI) Fellow, 2008 – 2010 NSF Division of Materials Research, Special Creativity Extension, 2008 – 2010 Frontiers in Chemical Research Distinguished Lecturer, Texas A&M University, 2007 Bayer Distinguished Lecturer, University of Pittsburgh, 2007 Dow Lecturer in Organic Chemistry, Massachusetts Institute of Technology, 2007 Outstanding Faculty Mentor Award, Washington University, 2007 Margaret C. Etter Memorial Lecturer, University of Minnesota, 2007 Phi Lambda Upsilon Lecturer, Kansas State University, Department of Chemistry, 2007 William H. Rauscher Lecturer, Rennselaer Polytechnic Institute, Department of Chemistry, 2006 James S. McDonnell Distinguished University Professor of Arts & Sciences, Washington University, 2006 – 2009 Distinguished Faculty Award, Washington University, 2005 NSF Division of Materials Research, Special Creativity Extension, 2002 – 2004 Arthur C. Cope Scholar Award in Organic Chemistry, 2002 Academy of Science of Saint Louis Innovation Award, 2002 Office of Naval Research Young Investigator Award, 1998 – 2001 Eastman Chemical Company Lecturer, University of Akron, Department of Polymer Science, 2000

Raychem Lecturer, University of California, Berkeley, Department of Chemistry, 1997 Army Research Office Young Investigator Award, 1996 – 1999 DuPont Young Professor Grant, 1996 – 1999 National Science Foundation National Young Investigator Award, 1994 – 1999 Robert W. Work Award for Excellence in Polymer Chemistry, Cornell University, 1992 ACS Sherwin Williams Student Award Finalist, ACS Division of Polymer Chemistry, 1992 Department of Education Fellowship, Cornell University, 1991 – 1993 S. C. Johnson & Sons Fellowship, Cornell University, 1990 – 1991 Phi Lambda Upsilon Member, Oregon State University

Professional Societies: American Academy of Arts and Sciences; Royal Society of Chemistry; American Association for the Advancement of Science; American Chemical Society (ACS); Division of Polymer Chemistry of the ACS (Publications Chair, 1999 – 2003, and Alternate Councilor, 2000 – 2005); Division of Polymeric Materials:

http://chemistry.oregonstate.edu/files/chem/OSU%20Chem%20Newsletter%20Spring%202012.pdf


Science and Engineering of the ACS; President of the Student Affiliates of the American Chemical Society at Oregon State University, 1986

Professional Activities: Advisory Board, Oregon State University, Department of Chemistry (2017 – 2020) Organizing Committee, National Science Foundation Nanoscale Science and Engineering Grantees

Conference, December 12-13, 2016 Executive Scientific Advisory Board Member, NANO / Molecular Medicine and Engineering Conference,

(NANOMED 2018) in Houston (2016 – 2018) External Member, University of Texas, San Antonio (UTSA) Welch Chair Committee (2015 – 2016) External Reviewer, Johns Hopkins University, Department of Chemistry (2015) Editorial Advisory Board, Nanotechnology, Science and Applications (2015 – present) Scientific Advisory Group Member for the International Symposium on Polymer Analysis and

Characterization (2014 – 2016) Technical Advisory Board, Organics, Polymers, and Organometallics (OPO TAB), Dow Chemical

Company (2014 – present) Associate Editor, J. Am. Chem. Soc. (2014 – present) Editorial Advisory Board, Polymers for Advanced Technologies (2014 – present) External Advisory Board, Research Triangle Park Materials Research Science and Engineering Center

(MRSEC) (2014 – 2015) Scientific Committee for the 6th Biennial Heart Valve Biology & Tissue Engineering Meeting, Royal

Society, London, (2013 – 2014) Selection Committee for the chair on polymer chemistry in the Department of Chemical Engineering &

Chemistry at Eindhoven University of Technology (2013 – 2014) External Advisory Board, University of Minnesota Center for Sustainable Polymers, an NSF Center for

Chemical Innovation (2013 – 2014) International Scientific Advisory Board, Max Planck Institute for Polymer Research (2013 – 2018) International Advisory Committee, International Conference on Materials Chemistry, MC11, Royal Society

of Chemistry, (2012 – 2013) Chair, NIH Nanotechnology Study Section Panel (2012 – 2014) Co-organizer, 14th International IUPAC Conference on Polymers and Organic Chemistry (2011 – 2012)

Editorial Advisory Board, Chemistry of Materials (2011 – present) International Advisory Committee, 44th International Symposium on Macromolecules – IUPAC World

Polymer Congress (2011 – 2012) Editorial Advisory Board, Journal of Biotechnology and Biomaterials – Open Access (2010 – 2013) Co-organizer, 2011 American Association for Cancer Research Symposium, “Nano in Cancer: Linking

chemistry, biology, and clinical applications in vivo“ (2010 – 2011) International Advisory Board, 20th IUPAC International Symposium on Ionic Polymerization (2010 – 2011) External Advisory Committee, University of Delaware, Materials Science and Engineering Dept. (2010 –

present) Standing Member, NIH Nanotechnology Study Section Panel (2010 – 2014) International Scientific Advisory Board, Dutch BioMedical Materials Program (2007 – 2014) External Advisory Committee, NSF-PREM Program (2007- 2011) External Advisory Board, University of Nebraska NIH COBRE Center (2007 – 2015) Editorial Advisory Board, Journal of the American Chemical Society (2007 – 2014) Editorial Advisory Board, Bioconjugate Chemistry (2007 – present) Chair, 2007 Polymers (East) Gordon Research Conference Co-organizer, 2007 NSF Polymers Workshop Mitsubishi Technical Advisory Board (2006) External Advisory Board, University of California-Santa Barbara, Materials Research Laboratory (2005 –

2015)


Advisory Board, Carnegie Mellon University, Department of Chemistry (2005) Co-organizer, 2005 USA-Japan Forum: “Advances in Polymer Chemistry and their Impacts upon Society” U.S. Area Coordinator for Materials Science and Nanotechnology for Pacifichem 2005 Vice Chair, 2005 Polymers (East) Gordon Research Conference Editorial Advisory Board, Langmuir (2005 – 2007) Editorial Advisory Board, Soft Matter (2005 – 2008) Editorial Advisory Board, International Journal of Nanomedicine (2005 – present) Extramural Scientific Advisory Panel for the NIH Nanomedicine Development Centers (2004 – 2009) International Advisory Board for the Royal Society of Chemistry, Materials Chemistry 7 Conference Advisory Board for the National Nanotechnology Infrastructure Network (NNIN) (2004 – 2008) Editor, Journal of Polymer Science, Part A: Polymer Chemistry (2003 – 2014) National Heart, Lung, and Blood Institute Nanotechnology Working Group (2003) National Science Foundation Nanomaterials Workshop Steering Committee (2003) NSF Steering Committee for Grand Challenges for Nanomaterials (2002) Arthur C. Cope Young Scholar Canvassing Committee for the ACS (2001 – 2004) Editorial Advisory Board, Macromolecules (2001 – 2004) Editorial Advisory Board, Nano Letters (2001 – 2006) Editorial Advisory Board, Journal of Polymer Science, Part A: Polymer Chemistry (2000 – 2003) Editorial Advisory Board, Journal of Supramolecular Chemistry (2000 – 2003) Alternate Councilor, American Chemical Society, Division of Polymer Chemistry (2000 – 2005) Research Corporation Program Advisory Committee (2000 – 2003) Publications Chair, American Chemical Society Division of Polymer Chemistry (1999 – 2003)

Professional Committee Activities within Texas A&M University: Department of Chemistry

Member, Department of Chemistry Head Search Advisory Committee (2016) Member, Chair/Professorship Advisory/Selection Committee (2014 & 2015) Chair, Organic Faculty Search Committee (2014 – 2015) Member, Academic Operations Committee (2014 – 2016) Chair, Division of Organic Chemistry (2014 – 2016) Member (organic), Promotion & Tenure Committee (2014 – 2016); Chair, Promotion & Tenure Committee

(2016-2017) Member, Chemistry Department Head Search Advisory Committee (2013 – 2014) Unit Coordinator, State Employee Charitable Campaign (2012) Member, Internal Committee to prepare for Provost’s External Review of Chemistry Dept. (2012 – 2013) Member (at-large), Executive Committee (2009 – 2012) Member, Faculty Search Committee, Department of Chemistry (2010 – 2012) Chair, Chemistry Department Joint Appointments Committee (2011 – present) Texas A&M University

Chair, Joint College of Engineering-College of Science Curriculum Committee (JC4) (2016 – present) Member, Sponsored Research Services (SRS) Transition and Services Operations Committee (TSOC) (2015

– present) Chair, Covestro Lectureship Committee, Department of Chemistry, w/membership also from the College of

Engineering (Departments of Chemical Engineering and Mechanical Engineering) (2015 – present) Member, Imaging Working Group (2015 – present) Member, Research Development Fund Advisory Committee (2015 – 2016) Member, Vice President of Research Search Committee (2012 – 2013) Member, F. A. Cotton Medal Jury (2012 – 2015) Member, Texas A&M Institute for Advanced Study (TIAS) Administrative Council (2011 – 2013) Member, ADVANCE-IT Project, Departmental Mini-Grants Subcommittee (2011 – 2015)


Member, Faculty Search Committee, Marine Sciences Department, Texas A&M University at Galveston (2011 – 2012)

Chair, Bayer Lectureship Committee, Department of Chemistry, w/membership also from the College of Engineering (Departments of Chemical Engineering and Mechanical Engineering) (2010 – 2015)

Member, Faculty Search Committee, Department of Nuclear Engineering, Life Sciences Radiochemistry (2010 – 2013)

Member, Strengthen Graduate Programs Imperative Study Team, Vision 2020 Task Force (2010 – 2012) Member, Faculty Search Committee, Department of Nuclear Engineering, Nuclear Forensics,

Nonproliferation, and/or Nuclear Security Risk Analysis (2010 – 2012) Member, Faculty Search Committee, Department of Biochemistry and Biophysics (2010 – 2011)

Professional Committee Activities within Washington University: Department of Chemistry

Laboratory Oversight Committee (2005 – 2009) Chair, Chemistry Graduate Recruitment Committee (2000 – 2002) Graduate Work Committee (2000 – 2009) Organizer and host for Bayer Distinguished Lectureship (2000 – 2009) Graduate Admissions and Recruitment Committees (1999 – 2007) McMillen Laboratory Renovations Committee (1998 – 2000) Faculty search committees (1995 – 2000, 2002 – 2004) Graduate Recruitment Committee (1994 – 2007) Safety Committee (1994 – 2009) Washington University

Advisory Committee on the Appointment of the Dean of the Faculty of Arts & Sciences (2008) Committee on the Appointment of the Interim Dean of Engineering (2008) Faculty Advisory Committee (2007) Review Committee on Faculty Personnel Procedures (2007 – 2009) Office for Technology Management Directorship Search Committee (2006 – 2007) McKelvey Professorship Search Committee (2006 – 2007) Chair, School of Engineering, Faculty member tenure and promotion committee (2006 – 2007) Siteman Cancer Center Strategic Planning Group (Spring 2006) Joint Chemistry/Biology Faculty Search Committee (2005 – 2006) Nanotechnology Advisory Group (2004 – 2009) Kauffman Entrepreneurship Pathway (DBBS) Advisory Committee (2004 – 2009) Compton/Ferguson Lectures Committee (2003 – 2009) Animal Studies Committee (2003 – 2006) Steering Committee for Beckman Scholars Program (2002 – 2009) Task Force Sub-committee for Materials (2002 – 2003) Dean’s Advisory Committee on Tenure, Promotion and Personnel (2001 – 2004) Division of Biology and Biomedical Sciences Internal Review Committee (2001 – 2002) Olin Fellowship Selection Committee (2000) Chemistry-Biology Interface Steering Committee (2000 – 2006) Physics Biological/Biomedical Faculty Search Committee (1999) Committee for Faculty Oversight of Technology Transfer (1999 – 2009) Educational Policy Committee of the Board of Trustees (1999 – 2001)

Research Interests: Organic and polymer synthesis; novel macromolecular nanostructures for biomedical and materials applications; degradable polymers; nanoscale polymer assemblies; functional polymers; polymer modification.

Publications (peer reviewed):


Submitted—

311. Zigmond, J. S.; Wooley, K. L. “Amphiphilic Crosslinked Liquid Crystalline Fluoropolymer-Poly(ethylene glycol) Coatings for Application in Challenging Conditions: Comparative study between different liquid crystalline comonomers and polymer architectures”, ACS Appl. Mater. Interfaces, submitted.

310. Mohamed. N. K.; Hamad, M. A.; Hafez, M. Z. E.; Wooley, K. L.; Elsabahy M. “Nanomedicine in Management of Hepatocellular Carcinoma: Challenges and Opportunities”, International J. Cancer, submitted.

309. Zinnel, N.; Pai, P.-J.; Mikami, K.; Lonnecker, A.; Gustafson, T.; Wooley, K. L.; Russell, D. “Probing the Regiochemistry of Glucose-Derived Polycarbonates by Mass Spectrometry”, Anal. Chem., submitted.

308. Kristufek, S. L.; Pollack, K. A.; Gustafson, T. P.; Raymond, J. E.; Wooley, K. L. “A regiochemically-controlled, high modulus and fluorescent poly(quercetin carbonate) as a biorenewable system designed for advanced engineering applications”, Polym. Chem., submitted.

306. Flores, J. A.; Jahnke, A. A.; Cheng, Z.; Wooley, K. L. “Magnetically-active Pickering Emulsions Stabilized by Hybrid Inorganic/Organic Networks”, Soft Matter, submitted.

305. Shah, P. N.; Smolen, J. A.; Shah, K. N.; Tagaev, J. A.; Torrealba, J.; Zhang, S.; Zhang, F.; Wagers, P. O.; Panzner, M. J.; Youngs, W. J.; Wooley, K. L.; Cannon, C. L. “In vitro metric predicts in vivo

efficacy of inhaled silver-based antimicrobials in a mouse model of Pseudomonas aeruginosa

pneumonia”, Antimicrob. Agents Chemother., submitted. 304. Lonnecker, A. T.; Lim, Y. H.; Felder, S. E.; Besset, C. J.; Wooley, K. L. “Four Different Regioisomeric

Polycarbonates Derived from One Natural Product, ᴅ-Glucose”, Macromolecules, submitted. In press—

307. Yang, G.; Kristufek, S. L.; Link, L. A.; Wooley, K. L.; Robertson, M. L. “Thiol-ene elastomers derived from biobased phenolic acids with varying functionality”, Macromolecules, in press.

Published—

303. Wacker, K. T.; Kristufek, S. L.; Lim, S.-M.; Kahn, S.; Wooley, K. L. “Bio-based Polycarbonates Derived from the Neolignan Honokiol”, RSC Advances, 2016, 6, 81672-81679, DOI: 10.1039/C6RA19568G.

302. Kristufek, S. L.; Yang, G.; Link, L. A.; Rohde, B. J.; Robertson, M. L.; Wooley, K. L. “Synthesis, Characterization and Cross-linking Strategy of a Quercetin-based Epoxidized Monomer as a Naturally-Derived Replacement for BPA in Epoxy Resins”, Chem. Sus. Chem., 2016, 9, 2135-2142, DOI: 10.1002/cssc.201600392.

301. Lim, Y. H.; Tiemann, K. M.; Hunstad, D. A.; Elsabahy, M.; Wooley, K. L. “Polymeric Nanoparticles in Development for Treatment of Pulmonary Infectious Diseases”, Wiley Interdisciplinary Reviews

(WIREs): Nanomed. Nanobiotechnol., 2016, doi: 10.1002/wnan.1401. 300. Zigmond, J. S.; Pavia-Sanders, A.; Russell, J. D.; Wooley, K. L. “Dynamic Anti-icing Coatings:

Complex, amphiphilic hyperbranched fluoropolymer poly(ethylene glycol) crosslinked networks with an integrated liquid crystalline comonomer”, Chem. Mater., 2016, 28(15), 5471-5479, DOI:10.1021/acs.chemmater.6b02013.

299. He, X.; Fan, J.; Zou, J.; Wooley, K. L. “Reversible Photo-patterning of Soft Conductive Materials via Spatially-defined Supramolecular Assembly”, Chem. Commun., 2016, 52, 8455-8458.

298. Zhao, Y.; Detering, L.; Sultan, D.; Cooper, M.; You, M.; Cho, S.; Meier, S.; Luehmann, H.; Sun, G.; Rettig, M.; Dehdashti, F.; Wooley, K. L.; DiPersio, J.; Liu, Y. “Gold Nanoclusters Doped with 64Cu for CXCR4 Positron Emission Tomography Imaging of Breast Cancer and Metastasis”, ACS Nano, 2016, 10(6), 5959-5970, DOI: 10.1021/acsnano.6b01326.

297. Black, K. C.; Ibricevic, A.; Gunsten, S. P.; Flores, J. A.; Gustafson, T. P.; Raymond, J. E.; Samarajeewa, S.; Shrestha, R.; Felder, S. E.; Cai, T.; Shen, Y.; Lӧbs, A. K.; Zhegalova, N.; Sultan, D. H.; Berezin, M.;

Wooley, K. L.; Liu, Y.; Brody, S. “In vivo fate tracking of degradable nanoparticles for lung gene transfer using PET and Ĉerenkov imaging”, Biomaterials, 2016, 98, 53-63, DOI:10.1016/j.biomaterials.2016.04.040.


296. Kristufek, T. S.; Kristufek, S. L.; Link, L. A.; Weems, A. C.; Lonnecker, A. T.; Raymond, J. E.; Maitland, D. J.; Wooley, K. L. “Rapidly-cured Isosorbide Natural Product-based Cross-linked Polycarbonate Elastomers”, Polym. Chem., 2016, 7, 2639-2644, DOI: 10.1039/c5py01659b.

295. He, X.; Fan, J.; Wooley, K. L. “Stimuli-triggered Sol-Gel Transitions of Polypeptide Gels Derived from N-carboxyanhydride (NCA) Polymerizations”, Chem. Asian J., 2016, 11, 437–447, DOI: 10.1002/asia.201500957.

294. Zigmond, J. S.; Pollack, K. A.; Smedley, S.; Raymond, J. E.; Link, L. A.; Pavia-Sanders, A.; Hickner, M. A.; Wooley, K. L. “Investigation of Intricate, Amphiphilic Crosslinked Hyperbranched Fluoropolymers as Anti-icing Coatings for Extreme Environments”, J. Polym. Sci., Part A: Polym.

Chem., 2016, 54(2), 238–244, DOI: 10.1002/pola.27800. 293. Cho, S.; Heo, G. S.; Khan, S.; Gonzalez, A. M.; Elsabahy, M.; Wooley, K. L. “A Hydrophilic

Polycarbonate, Poly(5-methyl-5-(2-hydroxypropyl)aminocarbonyl-1,3-dioxan-2-one), Designed as a Degradable Alternative for PHPMA and PEG”, Macromolecules, 2015, 48(24), 8797–8805, DOI: 10.1021/acs.macromol.5b01974.

292. Yang, G.; Kristufek, S.; Link, L.; Wooley, K. L.; Robertson, M. “Synthesis and Physical Properties of Thiol-Ene Networks Utilizing Plant-Derived Phenolic Acids”, Macromolecules, 2015, 48(23), 8418-8427, DOI: 10.1021/acs.macromol.5b01796.

291. Yang, F.; Cho, S.; Sun, G.; Verkhoturov, S. V.; Thackeray, J. W.; Trefonas, P.; Wooley, K. L.; Schweikert, E. A. “Nanodomain Analysis with Cluster-SIMS: Application to the characterization of macromolecular brush architecture”, Surface and Interface Analysis, 2015, 47(11), 1051-1055, DOI: 10.1002/sia.5812.

290. Elsabahy, M.; Heo, G. S.; Lim, S.-M.; Sun, G.; Wooley, K. L. “Polymeric Nanostructures for Imaging and Therapy”, Chem. Rev., 2015, 115, 10967-11011, DOI: 10.1021/acs.chemrev.5b00135.

289. Chen, Y.; Zhang, K.; Wang, X.; Zhang, F.; Zhu, J.; Mays, J. W.; Wooley, K. L.; Pochan, D. J. “Multigeometry nanoparticles: Hybrid vesicle/cylinder nanoparticles constructed with block copolymer

solution assembly and kinetic control”, Macromolecules, 2015, 48(16), 5621-5631, DOI: 10.1021/acs.macromol.5b00752.

288. Wagers, P. O.; Tiemann, K. M.; Shelton, K. L.; Kofron, W. G.; Panzner, M. J.; Wooley, K. L.; Youngs, W. J.; Hunstad, D. A. “Imidazolium salts as small-molecule urinary bladder exfoliants in a murine model”, Antimicrobial Agents and Chemotherapy, 2015, 59(9), 5494-5502, DOI: 10.1128/AAC.00881-15. PMCID: PMC4538537.

287. Weems, A. C.; Raymond, J. E.; Wacker, K. T.; Gustafson, T. P.; Keller, B.; Wooley, K. L.; Maitland, D. J. “Examination of radio-opacity enhancing additives in shape memory polyurethane foams”, J. Appl.

Polym. Sci., 2015, 132(33), 42054 (9 pp), DOI: 10.1002/app.42054. 286. Hearon, K.; Wierzbicki, M. A.; Nash, L. D.; Landsman, T. L.; Laramy, C.; Lonnecker, A. T.; Gibbons,

M. C.; Ur, S.; Cardinal, K. O.; Wilson, T. S.; Wooley, K. L.; Maitland, D. J. “A Processable Shape Memory Polymer System for Biomedical Applications”, Adv. Healthcare Mater., 2015, 4, 1386-1398, DOI: 10.1002/adhm.201500156.

285. Aweda, T. A.; Zhang, S.; Mupanomunda, C.; Burkemper, J.; Heo, G. S.; Bandara, N.; Lin, M.; Cutler, C. S.; Cannon, C. L.; Youngs, W. J.; Wooley, K. L.; Lapi, S. E. “Investigating the pharmacokinectics

and biological distribution of silver-loaded polyphosphoester-based nanoparticles using 111Ag as a radiotracer”, J. Labelled Comp. Radiopharm., 2015, 58(6), 234-241, DOI: 10.1002/jlcr.3289. PMCID: PMC4457551.

284. Noel, A.; Borguet, Y. P.; Wooley, K. L. “Self-reporting Degradable Fluorescent Grafted Copolymer Micelles Derived from Biorenewable Resources”, ACS Macro Lett., 2015, 4(6), 645-650, DOI: 10.1021/acsmacrolett.5b00227. PMCID: PMC4477896.

283. Elsabahy, M.; Wooley, K. L. “Data Mining as a Guide for the Construction of Biocompatible Nanoparticles via Controlling Polymer Chemistry and Supramolecular Assembly”, Acc. Chem. Res., 2015, 48(6), 1620-1630, DOI: 10.1021/acs.accounts.5b00066. PMCID: PMC4500541.


282. Flores, J. A.; Pavia-Sanders, A.; Chen, Y.; Pochan, D. J.; Wooley, K. L. “Recyclable Hybrid Inorganic/Organic Magnetically-active Networks for the Sequestration of Crude Oil from Aqueous Environments”, Chem. Mater., 2015, 27, 3775-3782, DOI: 10.1021/acs.chemmater.5b01523.

281. Seetho, K.; Zhang, S.; Pollack, K. A.; Zou, J.; Raymond, J. E.; Wooley, K. L. “Facile Synthesis of a Phosphorylcholine-based Zwitterionic Amphiphilic Copolymer for Anti-Biofouling Coatings”, ACS

Macro Lett., 2015, 4, 505-510, DOI: 10.1021/mz500818c. 280. Lim, Y. H.; Tiemann, K. M.; Heo, G. S.; Wagers, P. O.; Rezenom, Y. H.; Zhang, S.; Zhang, F.; Youngs,

W. J.; Hunstad, D. A.; Wooley, K. L. “Preparation and in vitro Antimicrobial Activity of Silver-bearing Degradable Polymeric Nanoparticles of Polyphosphoester-block-Poly(L-lactide)”, ACS Nano, 2015, 9(2), 1995-2008, DOI: 10.1021/nn507046h. PMCID: PMC4455953.

279. Zhang, F.; Zhang, S.; Pollack, S. F.; Li, R.; Gonzalez, A. M.; Fan, J.; Zou, J.; Leininger, S. E.; Pavia-Sanders, A.; Johnson, R.; Nelson, L. D.; Raymond, J. E.; Elsabahy, M.; Hughes, D. M. P.; Lenox, M. W.; Gustafson, T. P.; Wooley, K. L. “Improving Paclitaxel Delivery: In vitro and in vivo characterization of PEGylated polyphosphoester-based nanocarriers”, J. Am. Chem. Soc., 2015, 137, 2056-2066, DOI: 10.1021/ja512616s.

278. Zhang, F.; Smolen, J. A.; Zhang, S.; Li, R.; Shah, P. N.; Cho, S.; Wang, H.; Raymond, J. E.; Cannon, C. L.; Wooley, K. L. “Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infections”, Nanoscale, 2015, 7, 2265-2270, DOI: 10.1039/c4nr07103d.

277. Sun, G.; Cho, S.; Yang, F.; He, X.; Pavia-Sanders, A.; Clark, C.; Raymond, J. E.; Verkhoturov, S. V.; Schweikert, E. A.; Thackeray, J. W.; Trefonas, P.; Wooley, K. L. “Advanced Photoresist Technologies by Intricate Molecular Brush Architectures: Diblock brush terpolymer-based positive-tone photoresist materials”, J. Polym. Sci., Part A: Polym. Chem., 2015, 53, 193-199, DOI: 10.1002/pola.27362.

276. Pollack, K. A.; Imbesi, P. M.; Raymond, J. E.; Wooley, K. L. “Hyperbranched Fluoropolymer-Polydimethylsiloxane-Poly(ethylene glycol) Crosslinked Terpolymer Networks Designed for Marine and Biomedical Applications: Heterogeneous non-toxic anti-biofouling surfaces”, ACS Appl. Mater.

Interfaces, 2014, 6, 19265-19274, DOI: 10.1021/am505296n. 275. Noel, A.; Borguet, Y. P.; Raymond, J. E.; Wooley, K. L. “Poly(ferulic acid-co-tyrosine): Effect of

the regiochemistry on the photophysical and physical properties, en route to biomedical applications”, Macromolecules, 2014, 47(20), 7109-7117, DOI: 10.1021/ma5015534. PMCID: PMC4211680.

274. Link, L. A.; Lonnecker, A. T.; Hearon, K.; Raymond, J. E.; Maitland, D. J.; Wooley, K. L. “Photo-crosslinked Poly(thioether-co-carbonate) Networks Derived from the Natural Product Quinic Acid”,

ACS Appl. Mater. Interfaces, 2014, 6, 17370-17375, DOI: 10.1021/am506087e. 273. He, X.; Fan, J.; Zhang, F.; Li, R.; Pollack, K. A.; Raymond, J. E.; Zou, J.; Wooley, K. L. “Multi-

responsive Hydrogels Derived from the Self-assembly of Tethered Allyl-functionalized Racemic Oligopeptides”, J. Mater. Chem. B, 2014, 2(46), 8123-8130, DOI: 10.1039/C4TB00909F. PMCID: PMC4255538.

272. Elsabahy, M.; Wooley, K. L. “Core-shell Nanoparticles for Biomedical Applications.” Handbook of

Nanobiomedical Research: Fundamentals, Applications and Recent Developments Volume 1: Materials

for Nanomedicine. Vol. 3. Ed. V. Torchilin. Singapore: WorldScientificOpen, 2014. 475-517. Print. 271. Lim, Y. H.; Heo, G. S.; Rezenom, Y. H.; Pollack, S.; Raymond, J. E.; Elsabahy, M.; Wooley, K. L.

“Development of a Vinyl Ether-functionalized Polyphosphoester as a Template for Multiple Post-polymerization Conjugation Chemistries and Study of Core Degradable Polymeric Nanoparticles”,

Macromolecules, 2014, 47, 4634-4644, DOI: 10.1021/ma402480a. PMCID: PMC4296319. 270. Zou, J.; He, X.; Fan, J.; Raymond, J. E.; Wooley, K. L. “Supramolecularly-knitted Tethered

Oligopeptide/Single-walled Carbon Nanotube Organogels”, Chem. Eur. J., 2014, 20, 8842-8847, DOI: 10.1002/chem.201403027. PMCID: PMC4139973.

269. Fan, J.; Li, R.; He, X.; Seetho, K.; Zou, J.; Wooley, K. L. “Construction of a versatile and functional nanoparticle platform derived from a helical diblock copolypeptide-based biomimetic polymer”, Polym.

Chem., 2014, 5, 3977-3987, DOI: 10.1039/C4PY00628C. PMCID: PMC4084918.


268. Noel, A.; Borguet, Y. P.; Raymond, J. E.; Wooley, K. L. “Poly(carbonate-amide)s derived from bio-based resources: Poly(ferulic acid-co-tyrosine)”, Macromolecules, 2014, 47, 2974-2983, DOI: 10.1021/ma500454f. PMCID: PMC4020594.

267. Heo, G. S.; Cho, S.; Wooley, K. L. “Aldehyde-Functional Polycarbonates as Reactive Platforms”,

Polym. Chem., 2014, 5, 3555-3558, DOI: 10.1039/c4py00456f. PMCID: PMC4285359. 266. Hearon, K.; Nash, L. D.; Rodriguez, J. N.; Lonnecker, A. T.; Raymond, J. E.; Wilson, T. S.; Wooley, K.

L.; Maitland, D. J. “A High-Performance Recycling Solution for Polystyrene Achieved by the Synthesis of Renewable Poly(thioether) Networks Derived from D-Limonene”, Adv. Mater., 2014, 26(10), 1552-1558, DOI: 10.1002/adma.201304370. PMCID: PMC4000729.

265. Gustafson, T. P.; Lim, Y. H.; Flores, J. A.; Heo, G. S.; Zhang, F.; Zhang, S.; Samarajeewa, S.; Raymond, J. E.; Wooley, K. L. “Holistic assessment of covalently-labelled core-shell polymeric nanoparticles with fluorescent contrast agents towards theranostic applications”, Langmuir, 2014, 30(9), 631-641, DOI: 10.1021/la403943w. PMCID: PMC3933954.

264. Zou, J.; Zhang, F.; Zhang, S.; Pollack, S. F.; Elsabahy, M.; Fan, J.; Wooley, K. L. “Poly(ethylene

oxide)-block-polyphosphoester-graft-paclitaxel Conjugates with Acid-labile Linkages as a pH-Sensitive and Functional Nanoscopic Platform for Paclitaxel Delivery”, Adv. Healthcare Mater., 2014, 3(3), 441-448, DOI: 10.1002/adhm.201300235. PMCID: PMC3938983.

263. Cho, S.; Yang, F.; Sun, G.; Eller, M. J.; Clark, C.; Schweikert, E. A.; Thackeray, J. W.; Trefonas, P.; Wooley, K. L. “Directing Self-assembly of Nanoscopic Cylindrical Diblock Brush Terpolymers into Films with Desired Spatial Orientations: Expansion of chemical composition scope”, Macromol. Rapid

Commun., 2014, 35(4), 437-441, DOI: 10.1002/marc.201300845. 262. Fan, J.; Zou, J.; He, X.; Zhang, F.; Zhang, S.; Raymond, J. E.; Wooley, K. L. “Tunable mechano-

responsive organogels by ring-opening copolymerizations of N-carboxyanhydrides”, Chem. Sci., 2014, 5, 141-150, DOI: 10.1039/c3sc52504j. PMCID: PMC3865608.

261. Samarajeewa, S.; Zentay, R. P.; Jhurry, N. D.; Li, A.; Seetho, K.; Zou, J.; Wooley, K. L. “Programmed Hydrolysis of Nanoassemblies by Electrostatic Interaction-mediated Enzymatic-degradation”, Chem.

Commun., 2014, 50(8), 968-970, DOI: 10.1039/c3cc46013d. PMCID: PMC4165354. 260. Zhao, Y.; Sultan, D.; Detering, L.; Cho, S.; Sun, G.; Pierce, R.; Wooley, K. L.; Liu, Y. “Positron Emitter

Alloyed Gold Nanoparticle for Cancer Imaging: Improved Radiolabel Stability and Diagnostic Accuracy”, Angew. Chem., 2014, 53, 156-159, DOI: 10.1002/anie.201308494.

259. Trefonas, P.; Thackeray, J. W.; Sun, G.; Cho, S.; Clark, C.; Verkhoturov, S. V.; Eller, M. J.; Li, A.; Pavia-Jimenez, A.; Schweikert, E. A.; Wooley, K. L. “Bottom-up/Top-down High Resolution, High Throughput Lithography using Vertically Assembled Block Bottle Brush Polymers”, SPIE Proceedings, 2013, paper 8682-37.

258. Hearon, K.; Besset, C. J.; Lonnecker, A. T.; Ware, T.; Voit, W. E.; Wilson, T. S.; Wooley, K. L.; Maitland, D. J. “A Structural Approach to Establishing a Platform Chemistry for the Tunable, Bulk Electron Beam Crosslinking of Shape Memory Polymer Systems”, Macromolecules, 2013, 46(22), 8905-8916, DOI: 10.1021/ma4018372. PMCOD: PMC4234199.

257. Elsabahy, M.; Li, A.; Sultan, D.; Liu, Y.; Wooley, K. L. “Differential immunotoxicities of poly(ethylene glycol)- vs. poly(carboxybetaine)-coated nanoparticles”, J. Controlled Release, 2013, 172(3), 641-652, DOI: 10.1016/j.jconrel.2013.09.010. PMCID: PMC3858532.

256. Ibricevic, A.; Gunsten, S. P.; Zhang, K.; Shrestha, R.; Liu, Y.; Sun, J. Y.; Welch, M. J.; Taylor, J. S.; Wooley, K. L.; Brody, S. L. “PEGylation of Cationic, Shell Crosslinked Knedel-like Nanoparticles Modulates Inflammation and Enhances Cellular Uptake in the Lung”, Nanomedicine: Nanotechnology,

Biology and Medicine, 2013, 9(7), 912-922, DOI: 10.1016/j.nano.2013.02.006. PMCID: PMC3724762. 255. Trefonas, P.; Thackeray, J. W.; Sun, G.; Cho, S.; Clark, C.; Verkhoturov, S. V.; Eller, M. J.; Li, A.;

Pavia-Jimenez, A.; Schweikert, E. A.; Wooley, K. L. “Bottom-up/Top-down High-resolution, High-throughput Lithography using Vertically Assembled Block Bottle Brush Polymers”, J. Micro/Nanolith.

MEMS MOEMS., 2013, 12 (4), 043006 (December 16, 2013), DOI: 10.1117/1.jmm.12.4.043006. 254. Elsabahy, M.; Zhang, S.; Zhang, F.; Deng, Z. J.; Lim, Y. H.; Wang, H.; Parsamian, P.; Hammond, P. T.;

Wooley, K. L. “Surface Charges and Shell Crosslinks Each Play Significant Roles in Mediating


Degradation, Biofouling, Cytotoxicity and Immunotoxicity for Polyphosphoester-based Nanoparticles”,

Scientific Reports, 2013, 3 : 3313, 1-10, DOI: 10.1038/srep03313. PMCID: PMC3837308. 253. Shen, Y.; Zhang, S.; Zhang, F.; Loftis, A.; Pavia-Sanders, A.; Zou, J.; Fan, J.; Taylor, J.-S. A.; Wooley,

K. L. “Polyphosphoester-based cationic nanoparticles serendipitously release integral biologically-active components to serve as novel degradable inducible nitric oxide synthase inhibitors”, Adv. Mater., 2013, 25, 5609-5614, DOI: 10.1002/adma.201302842. PMCID: PMC4404032.

252. Pavía-Sanders, A.; Zhang, S.; Flores, J. A.; Sanders, J. E.; Raymond, J. E.; Wooley, K. L. “Robust Magnetic/Polymer Hybrid Nanoparticles Designed for Crude Oil Entrapment and Recovery in Aqueous Environments”, ACS Nano, 2013, 7(9), 7552-7561, DOI: 10.1021/nn401541e.

251. Zhu, J.; Zhang, S.; Zhang, K.; Wang, X.; Mays, J. W.; Wooley, K. L.; Pochan, D. J. “Disk-Cylinder and Disk-Sphere Nanoparticles from Block Copolymer Blend Solution Construction”, Nature

Communications, 2013, 4:2297, DOI: 10.1038/ncomms3297. 250. Lim, Y. H.; Heo, G. S.; Cho, S.; Wooley, K. L. “Construction of a Reactive Diblock Copolymer,

Polyphosphoester-block-Poly(L-lactide), as a Versatile Framework for Functional Materials that are Capable of Full Degradation and Nanoscopic Assembly Formation”, ACS Macro Lett., 2013, 2(9), 785-789, DOI: 10.1021/mz400229m. PMCID: PMC3808001.

249. Gustafson, T. P.; Lonnecker, A. T.; Heo, G. S.; Zhang, S.; Dove, A. P.; Wooley, K. L. “Poly(ᴅ-glucose carbonate) Block Copolymers: A platform for natural product-based nanomaterials with solvothermatic characteristics”, Biomacromolecules, 2013, 14(9), 3346-3353, DOI: 10.1021/bm4010832.

248. Elsabahy, M.; Samarajeewa, S.; Raymond, J. E.; Clark, C.; Wooley, K. L. “Shell-crosslinked knedel-like nanoparticles induce lower immunotoxicity than their non-crosslinked analogs”, J. Mater. Chem. B, 2013, 1(39), 5241-5255, DOI: 10.1039/c3tb20668h. PMCID: PMC3811931.

247. Shen, Y.; Fang, H.; Zhang, K.; Shrestha, R.; Wooley, K. L.; Taylor, J.-S. A. “Efficient Protection and

Transfection of siRNA by Cationic Shell Crosslinked Knedel-like Nanoparticles (cSCKs)”, Nucleic Acid

Therapeutics, 2013, 23(2), 95-108, DOI: 10.1089/nat.2012.0390. PMCID: PMC3619153. 246. Wang, Z.; Zhang, K.; Shen, Y.; Smith, J.; Bloch, S.; Achilefu, S.; Wooley, K. L.; Taylor, J.-S. A.

“Imaging mRNA Expression Levels in Living Cells with PNA DNA Binary FRET Probes Delivered by Cationic Shell Crosslinked Nanoparticles”, Organic and Biomolecular Chemistry, 2013, 11(19), 3159-3167, DOI: 10.1039/c3ob26923j. PMCID: PMC3619153.

245. Zhang, S.; Wang, H.; Shen, Y.; Zhang, F.; Seetho, K.; Zou, J.; Taylor, J.-S. A.; Dove, A. P.; Wooley, K. L. “A Simple and Efficient Synthesis of an Acid-labile Polyphosphoramidate by Organobase-catalyzed Ring-opening Polymerization and Transformation to Polyphosphoester Ionomers by Acid Treatment”,

Macromolecules, 2013, 46(13), 5141-5149, DOI: 10.1021/ma400675m. PMCID: PMC3755629. 244. Lee, Y.-J. C.; Wu, B.; Raymond, J. E.; Zeng, Y.; Fang, X.; Wooley, K. L.; Liu, W. R. “A Genetically

Encoded Acrylamide Functionality”, ACS Chem. Biol., 2013, 8(8), 1664-1670, DOI: 10.1021/cb400267m. PMCID: PMC3746000.

243. Shah, P. N.; Lin, L. Y.; Smolen, J. A.; Tagaev, J. A.; Gunsten, S. P.; Han, D. S.; Heo, G. S.; Li, Y.; Zhang, F.; Zhang, S.; Wright, B. D.; Panzner, M. J.; Youngs, W. J.; Brody, S. L.; Wooley, K. L.; Cannon, C. L. “Synthesis, Characterization, and in vivo Efficacy of Shell Crosslinked Nanoparticle Formulations Carrying Silver Antimicrobials as Aerosolized Therapeutics”, ACS Nano, 2013, 7(6), 4977-4987, DOI: 10.1021/nn400322f.

242. Mikami, K.; Lonnecker, A. T.; Gustafson, T. P.; Zinnel, N. F.; Pai, P.-J.; Russell, D. H.; Wooley, K. L. “Polycarbonates Derived from Glucose via an Organocatalytic Approach”, J. Am. Chem. Soc., 2013, 135(18), 6826-6829, DOI: 10.1021/ja402319m.

241. Zou, J.; Zhang, F.; Zhang, S.; Fan, J.; Raymond, J. E.; Zhu, J.; Li, A.; Seetho, K.; He, X.; Pochan, D. J.; Wooley, K. L. “Responsive organogels formed by supramolecular self assembly of PEG-block-allyl-functionalized polypeptides into β-sheet-driven polymeric ribbons”, Soft Matter, 2013, 9(25), 5951-5958, DOI: 10.1039/c3sm50582k. PMCID: PMC4361078.

240. Zou, J.; Fan, J.; He, X.; Zhang, S.; Wang, H.; Wooley, K. L. “A Facile Glovebox-free Strategy to Significantly Accelerate the Syntheses of Well-defined Polypeptides by N-Carboxyanhydride (NCA)

Ry Young

EDUCATION:

1968 A.B. Biochemistry, Rice University, Houston, TX 1969 Massachusetts Institute of Technology, Boston, MA 1975 Ph.D. Molecular Biology, University of Texas at Dallas, Dallas, TX

PROFESSIONAL EXPERIENCE:

1969; 1971-73 NSF Predoctoral Fellow 1969 - 1971 Officer, U.S. Navy, combat systems, FLECOMPUTPROGCENPAC1973 - 1975 Graduate Assistant, U.T. Dallas Program in Molecular Biology1976 - 1978 NIH Postdoctoral Fellow1978 - 1986 Assist./Assoc. Professor of Medical Biochemistry, Texas A&M University1987 - now Professor of Biochemistry and Biophysics, Texas A&M University1987 - now Professor of Biology, Texas A&M University

2003 - 2004 Ex Executive Director of Research and Development, GangaGen Inc.2006 - now S Sadie Hatfield Professor of Agriculture, Texas A&M University 2010 - now Director, Center for Phage Technology, Texas AgriLife & Texas A&M University

TEACHING:

Courses Taught:

BICH 431/BICH631 (GENE 431/GENE631) – Molecular Genetics 1987-1993 The 400 level course is the Molecular Genetics course required of all Biology, Microbiology, Genetics, Molecular and Cell Biology, and Biochemistry majors and taken by nearly all life science majors on campus. In general, I shared this course with another faculty member. The 631 version had common lectures but different examinations and was supplemented by an additional lecture on the literature. The text for this course was alternately Watson's and Lewin's general texts (Molecular Biology of the Gene and Genes I-V).

BICH 689 – Tools of molecular biology; Topics in prokaryotic gene regulation 1987-1992 These are 1 hour modules on advanced subjects which were taught as intensive, 3 week graduate courses which met for 5 hours per week in the evenings. Enrollment was limited to graduate students who already had taken a BICH631-level course in molecular genetics. I taught these courses by myself, one per year, for several years. The concept was that a narrowly-defined specialty course was best taught in a total immersion mode. These were very popular courses and, especially in the cases of modules on gene regulation and the technology of cloning and recombinant DNA. BICH 411 – General biochemistry 1994-2001 This is the second semester of General Biochemistry, required of most life science major, including the huge Biomedical Science major, which in recent years has grown from a small pre-veterinary major to the largest life science major on campus. Topics start with the Embden-Meyerhof pathway and proceed through all of intermediary metabolism, concluding with basic molecular biology. Enrollment is typically 100-120 at the start of the course.

Dr Ryland Young

Sadie Hatfield Professor of Agriculture, Department of Biochemistry and Biophysics

Campus address: Department of Biochemistry and Biophysics Office Telephone: (979) 845-2087 300 Olsen Blvd, room 311A Office Fax: (970) 862-4718 Texas A&M University E-mail: [email protected] Station, Texas, 77843-2128

Ry Young

BICH 608 – Critical reading of the literature 1992-2001; Fall 2009, 2010 This is a 2-hour course on critical reading of the literature for incoming graduate students. It meets once per week in the evenings. In our implementation of the course, we take one topic and develop it throughout the semester. Each week, all the students must come to class prepared to present any or all parts of the assigned papers and critically evaluate the data. In my opinion, this is the most important first year course, serving to shock the students out of the undergraduate frame of mind where anything in a paper or textbook is assumed correct.

BICH 489 – Special topics in phage biology 2002-3, 2005 I had planned to teach a course in bacteriophage molecular biology for more than a decade. A 1 hour trial run with 28 students was taught in spring, 2002, and a full 3 hour course, with laboratory, with 11 students was taught for the first time in spring, 2003, with 11 students enrolled. It bookends the fall 3 hour undergraduate genomics project (see below). This course covers advanced topics in bacteriophage biology, emphasizing lambda and T4, and the history of phage biology as it underpins the development of modern biological science. It is intended for advanced undergraduates, including those participating in the NSF undergraduate genomics effort, and for interested graduate students. The syllabus is attached, along with a CD-ROM with examples of the 2005 lecture material. The website for the course is on WebCT.

BICH 489 – Practical Genomics for Undergraduates Fall 2002-2006; Spring 2009-2010 This is a laboratory and lecture course was developed and is currently supported as part of an NSF/USDA-funded effort to establish an undergraduate program in genomics. The central idea is that individual bacteriophage genomes are small enough for teams of undergraduates to sequence and analyze in a single school year. Student teams of 4-5 members are provided with libraries prepared from purified DNA of a bacteriophage. Phages that infect agronomically important bacteria have been chosen as the initial area of focus. The students learn and implement high-throughput robotic sequencing and assemble the completed genomes during the fall semester. Students from each team will spend the spring semester analyzing and annotating the genome sequences. In fall-spring of 2001-2, a start-up group of five undergraduate students determined the first sequence, as well as developed robust protocols and procedures for the laboratory and computer efforts. The enrollments for fall 2002 and 2003 were ~20 students each year, and for fall 2005, because of budget considerations, we had 10 students. A total of 57 students have participated, including 37 women and 13 students from under-represented minority ethnic groups. It has been well-received by the students and has been cited by several as a determinant in their plans to pursue a career in science. One student, a Hispanic female from a small South Texas town, credits her current position in the Biology doctoral program at M.I.T. to here experiences in the program:

“This program affected my choices and opportunities for grad school more than anything else I did in undergrad. Before I joined the program, my motivation for gaining lab experience was primarily so I could have a better chance at a decent technician position after I graduated or possibly as a way to direct my interests if I applied to a masters program... “

There has been real scientific progress, too. Under the day to day supervision of Dr. Elizabeth Summer, a research scientist in my group, the “G-nome” teams (3 to 5 students) have completed the sequencing of 12 Burkholderia phages, of which 9 have been annotated completely and submitted to GenBank. This is the only undergraduate genomics project of its kind in the country. Major publications resulting from the course have appeared in J. Mol. Biol. and in the Journal of Baceriology, and more are in the pipeline. Lectures and other materials can be found at http://dimer.tamu.edu/young/genomics/

BICH 432/GENE 432 – Moelcular Genetics Laboratory Spring 2006-2007 This is a laboratory course, primarily designed for BICH and GENE majors, who are required to take it or BICH414. The course will provide the students with laboratory experience during which they will actually apply many of the principles of molecular genetics to the conduct and analysis of experiments.

BICH 689 – Phage Biology Spring 2009, Fall 2010, Spring 2010 This course is a 3-credit, graduate-level, literature-based introduction to bacteriophage biology. It is built around a series of classical and current papers which highlight concepts necessary for a broad understanding of the molecular and cellular biology of bacteriophage infection, the structure and biochemistry of the macromolecules involved in phage morphogenesis, and quantitative aspects of phage ecology, diversity and evolution. Emphasis will be placed on quantitative and physico-chemical concepts, consistent with the roots of phage biology being in physics, rather than traditional biology. In addition, significant emphasis will be placed on developing skills for the critical interpretation of scientific literature. Although most of the reading will be in designated papers from the literature, there is a reference text: The Bacteriophages, edited by R. Calendar, (Oxford Press, 2006). Although copies will be kept in a departmental office for access by students, acquisition of the text is strongly encouraged both for the course and for future professional use. Other texts include out-of-print books which will be provided by the instructor for appropriate access by students.

BICH 672 –Fall 2009 Seminar-based course examining recent discoveries in the structure, function and assembly of biological membranes; oral presentation by students on current literature in molecular biology and biochemistry.

Ry Young

BICH 464 – Phage Genomics Spring 2010 This course is a 3-credit lecture-laboratory course for undergraduates focused on the genomics of bacteriophages, the viruses of bacteria. It has two broad aims: to equip the students with a basic understanding of the fundamentals of bacteriophage biology and to provide a real basic research experience in modern genomics, culminating in the writing of a real scientific paper on the genomics of a novel bacteriophage. The focus on bacteriophage biology is chosen not only because of the tractable size of phage genomes but also because phage biology is an important factor in ecology, evolution, and health, as well as being the original and still powerful model system for the development of molecular biology. This course is funded by the National Science Foundation.

PUBLICATIONS:

= as corresponding author

1. Gründling, A., Bläsi, U. and Young, R. (2000) Biochemical and genetic evidence forthree transmembrane domains in the class I holin, λ S. J. Biol. Chem 2725:769-76.

2. Young, R., Wang, I.-N., and Roof, W.D. (2000) Phages will out: strategies of host celllysis. Trends Microbiol 8:120-28.

3. Wang, I.-N., Smith, D.L., and Young, R. (2000) Holins: the protein clocks ofbacteriophage infections. Ann. Rev. Microbiol. 54:799-825.

4. Bernhardt, T.G., Roof, W.D., and Young, R. (2000) Genetic evidence that thebacteriophage φX174 lysis protein inhibits cell wall synthesis. Proc. Natl. Acad. Sci.USA 97:4297-302. PMCID: PMC18234

5. Gründling, A., Bläsi, U., and Young, R. (2000) Genetic and biochemical analysis ofdimer and oligomer interactions of the λ S holin. J. Bacteriol. 182:6082-90. PMCID:PMC94742

6. Grüendling, A., Smith, D.L., Bläsi, U., and Young, R. (2000) Dimerization between theholin and holin inhibitor of phage λ. J. Bacteriol. 182:6075-81. PMCID: PMC94741

7. Ramanculov, E. and Young, R. (2001) Functional analysis of the T4 t holin in a λcontext. Molec. Genet Genomics 265:345-53.

8. Bernhardt, T., Struck, D. K., and Young, R. (2001) The lysis protein E of φX174 is aspecific inhibitor of the MraY-catalyzed step in peptidoglycan synthesis. J. Biol.Chem. 276:6093-97.

9. Ramanculov, E., and Young, R. (2001) Genetic analysis of the T4 holin: topology andtiming. Gene 265:25-36.

10. Ramanculov, E. and Young, R. (2001) An ancient player unmasked: T4 rI encodes a t-specific antiholin. Molec. Microbiol. 41:575-83.

11. Gründling, A., Manson, M., and Young, R. (2001) Holins kill without warning. Proc.Natl. Acad. Sci. USA 16:9348-52. PMCID: PMC55423

12. Bernhardt, T.G., Wang, I.-N., Struck, D.K., and Young, R. (2001) A protein antibioticin the phage Qβ virion: diversity in lysis targets. Science 292:2326-29.

13. Young, R. (2002) Bacteriophage holins: deadly diversity. J. Mol. Microbiol.Biotechnol. 4:21-31.

14. Young, R. (2002) Molecular genetics of bacteria and phages, 2001. J. Bacteriol.184:2572-75. PMCID: PMC137945

15. Bernhardt, T.G., Roof, W.D., and Young, R. (2002) The E. coli FKBP-type PPIaseSlyD is required for the stabilization of the E lysis protein of bacteriophage φX174.

Ry Young

Molec. Microbiol. 45:99-108. 16. Bernhardt, T.G., Wang, I.-N., Struck, D. K., and Young, R. (2002) Breaking free:

“protein antibiotics” and phage lysis. Res. Microbiol. 153:493-501.17. Wang, I.-N., Deaton, J.D. and Young, R. (2003) Sizing the holin lesion with an

endolysin-β-galactosidase fusion. J. Bacteriol. 185:779-87. PMCID: PMC14281118. Deaton, J.D. Savva, C. G., Sun, J., Holzenburg, A. H. and Young, R. (2004) Functional

bacteriorhodopsin is efficiently solubilized and delivered to membranes by thechaperonin GroEL. Proc. Nat. Acad. Sci. USA 101:2281-86.

19. Xu, M., Struck, D. K., Deaton, J., Wang, I.-N and Young, R.. (2004) A signal-arrest-release sequence mediates export and control of the phage P1 endolysin. Proc. Nat.Acad. Sci. USA, 101:6415-20. PMCID: PMC404059

20. Summer, E., Carlos F. Gonzalez, C.F., Carlisle, T., Mebane, L.M., Cass, A. M., Savva,C. G. , LiPuma, J. J. and Young, R. (2004) Burkholderia cenocepacia phage BcepMuand a family of Mu-like phages encoding potential pathogenesis factors. J. Molec. Biol.340:49-65.

21. Deaton, J., Savva, C. G., Sun, J., Holzenburg, A., Berry, J. and Young, R. (2004)Solubilization and delivery by GroEL of megadalton complexes of the lambda holin.Protein Sci. 13:1778-86. PMCID: PMC2279943

22. Markov, D., Christie, G., Sauer, B., Calendar, R., Park, T., Young, R., and Severinov,K. (2004) P2 growth restriction on an rpoC mutant is suppressed by alleles of the Rz1homolog lysC. J. Bacteriol. 186:4628-37. PMCID: PMC438596

23. Xu M., Arulandu A., Struck D. K., Swanson, S., Sacchettini, J.C., Young, R. (2005)Disulfide isomerization after membrane release of its SAR domain activates P1lysozyme. Science 307:113-17.

24. Sun, J., Savva, C. G., Deaton, J., Kaback, H.R., Svrakic, M., Young, R., andHolzenburg, H. (2005) Asymmetric binding of membrane proteins to GroEL. Arch.Biochem. Biophys. 15:4352-57.

25. Dobozi-King, M., Seo, S., Kim, J.U., Young, R., Cheng, M., and Kish, L.B. (2005)Rapid detection and identification of bacteria: Sensing of Phage-Triggered Ion Cascade(SEPTIC). J. Biol. Phys. Chem. 5:3-7.

26. Adhya, S., Black, L., Friedman, D., Hatful, G., Kreuzer, K., Merril, C., Oppenheim, A.,Rohwer, F., and Young, R. (2005) 2004 ASM Conference on the New Phage Biology:the ‘Phage Summit’. Molec. Microbiol. 55:1300-14.

27. Tran, T.A.T., Struck, D.K., and Young, R. (2005) Periplasmic Domains Define Holin-Antiholin Interactions in T4 Lysis Inhibition. J. Bacteriol 187: 6631-40. PMCID:PMC1251592

28. Kish, L.B., Cheng, M., Kim, J.U., Seo, S., King, M.D., Young, R.F., Der, A., Schmera,G. (2005) Estimation of detection limits of the phage-invasion based identification ofbacteria. Fluctuations and Noise Letters 5:L105-8.

29. Summer, E.J., Gonzalez, C.F., Bomer, M., Carlile, T., Embry, A., Kucherka, A.M., Lee,J., Mebane, L., Morrison, W.C., Mark, L., King, M.D., LiPuma, J.J., Vidaver, A.K.,and Young, R. (2006) Divergence and mosaicism among virulent soil phages of theBurkholderia cepacia complex. J. Bacteriol 188: 255-68. PMCID: PMC1317576

30. Young, R., Henkin, T.M., Turnbough C.L. (2006) The phage meeting: Classical venue,new momentum. J. Bacteriol 188: 4597-600. PMCID: PMC1482981Park, T., Struck, D.K., Deaton, J.F., and Young, R. (2006) Topological dynamics of

Ry Young

holins in programmed bacterial lysis. Proc Natl Acad Sci USA 103: 19713-8. PMCID: PMC1750887

31. Summer, E.J., Gill, J., Upton, C., Gonzalez, C.F. and Young,R. (2007)Role of phages inthe pathogenesis of Burkholderia or "Where are the toxin genes in Burkholderiaphages?" Curr. Opin. Microbiol. 10:410-7. PMCID: PMC2064068

32. Tran, T.A.T., Struck, D.K., and Young, R. (2007) The T4 RI antiholin has an N-terminal SAR-domain that targets it for degradation by DegP. J. Bacteriol. 189:7618-25. PMCID: PMC2168629

33. Summer, E.J., Berry, J., Tran T.A., Niu, L., Struck, D.K., and Young, R. (2007) Rz/Rz1lysis gene equivalents in phages of Gram-negative hosts. J. Mol. Biol. 373: 1098-112.

34. Park, T., Struck, D. K., and Young, R. (2007) The pinholin of lambdoid phage 21:control of lysis by membrane depolarization. J. Bacteriol. 189: 9135-39PMCID:PMC2168629

35. Kish, L.B., Schmera, G., King, M.D., Cheng, M., Young, R., Granqvist, C.G.Fluctuation-enhanced chemical/biological sensing and prompt identification of bacteriaby sensing of phage triggered ion cascade (SEPTIC). Int. Jour. High Speed Elec.Syst. 18:11-18.

36. Savva, C.G., Dewey, J.S., Deaton, J., White, R.L., Struck, D.K., Holenburg, A., andYoung, R. (2008) The holin of bacteriophage lambda forms rings with large diameter.Mol. Microbiol. 69:784-93.

37. Zheng, Y., Struck, D.K., Dankenbring, C.A., and Young, R. (2008) Evolutionarydominance of holin lysis systems derives from superior genetic malleability. Microbiol.154: 1710-18.

38. Zheng, Y, Struck, D.K., Bernhardt, T.G. and Young, R. (2008) Genetic analysis ofMraY inhibition by the φX174 protein E. Genetics 180:1459-66. PMCID:PMC2581948

39. Young, R.F. and White, R.L. (2008) Lysis of the host by bacteriophage. Encyclopediaof Virology. 5:249-58.

40. Berry, J., Summer, E.J., Struck, D.K., and Young, R. (2008) The final step in the phageinfection cycle: the Rz and Rz1 lysis proteins link the inner and outer membranes. Mol.Microbiol. 70 :341-51.

41. Young, R.F. (2008) Molecular biology. Secret weapon. Science 321: 922-23.42. Zheng, Y., Struck, D.K., and Young, R. (2009) Purification and functional

characterization of the the φX174 lysis protein E. Biochem. 48:4999-5006.43. Dewey, J.S., Struck, D.K., Young, R. (2009) Thiol protection in membrane protein

purifications: a study with phage holins. Anal. Biochem. 390: 221-223. PMCID:PMC2735789

44. Sun, Q., Kuty, G.F., Arockiasamy, A., Xu, M., Young, R. and Sacchettini, J.C. (2009)Regulation of a muralytic enzyme by dynamic membrane topology. Nat Struct MolBiol. 16:1192-94.

45. Pang, T., Savva, C.G., Fleming, K.G., Struck, D.K., and Young, R. (2009) Structure ofthe lethal phage pinhole. Proc Nat Acad Sci USA 106:18966-71. PMCID:PMC2776468

46. Carmody, L.A., Gill, J.J., Sajjan, U.S., Gonzalez, C.F., Young, R.F. and LiPuma, J.J.(2010) Efficacy of bacteriophage therapy in a model of Burkholderia pulmonaryinfection. J Infect Dis 201: 264-71. PMCID: PMC2814432

Ry Young

47. Summer, E.J., Enderle, C.J., Ahern, S.J., Gill, J.J., Torres, C.P., Appel, D.N., Black,M.C., Young, R., and Gonzalez, C.F. (2010) Genomic and biological analysis of phageXfas53 and related prophages of Xylella fastidiosa. J. Bacteriol. 192:179-81. PMCID:PMC2798268

48. Buddelmeijer, N. and Young, R. (2010) The essential E. coli apolipoprotein N-acyltransferase (Lnt) exists as an Extracytoplasmic Thioester Acyl-Enzymeintermediate. Biochemistry 49:341-46.

49. Dewey, J.S., Savva, C.G., White, R.L., Holzenburg, A, Young, R. (2010) Micron-scaleholes terminate the phage infection cycle. Proc Nat Acad Sci USA 107:2219-23.PMCID: PMC2836697

50. Pang, T., Park, T., and Young, R. (2010) Mutational analysis of the S21 pinholin.Molec. Microb. 76:68-77.

51. White, R., Tran, T.A., Dankenbring, C.A., Deaton, J. and Young, R. (2010) The N-terminal transmembrane domain of λ S is required for holin but not antiholin function.J. Bacteriol. 192:725-33. PMCID: PMC2812449

52. Berry, J., Savva, C., Holzenburg, A., and Young, R. (2010) The lambda spanincomponents Rz and Rz1 undergo tertiary and quaternary rearrangements upon complexformation. Protein Science 19:1967-77.

53. Kuty, G., Xu, M., Struck, D., Summer, E., and Young, R. (2010) Regulation of a phageendolysin by disulfide caging. J. Bacteriology 192:5682-87.

54. Pang, T., Park, T. and Young, R. (2010) Mapping the pinhole formation pathway of S21.Mol. Microbiol. MMI-2010-10257

CURRICULUM VITAJOSHUA S. YUAN

2123 TAMUCollege Station, TX 77843

Cell: 510 919 7668Office: 979 845 3016

Email: [email protected] Experience2013 – now Associate Professor

Department of Plant Pathology and Microbiology Faculty of Institute for Plant Genomics and Biotechnology Texas A&M Energy InstituteGraduate Program in Biotechnology Texas A&M University (TAMU), College Station, TX

2015 – now DirectorSynthetic and Systems Biology Innovation Hub (SSBiH)Texas A&M University (TAMU), College Station, TX

2013 – now Chief Scientific AdvisorSynShark LLC

2008 – 2013 Assistant Professor in Bioinformatics and Systems BiologyDepartment of Plant Pathology and MicrobiologyInstitute for Plant Genomics and BiotechnologyTexas A&M University, College Station, TX

2004 – 2008 Director, Institute of Agriculture (UTIA) Genomics Hub Genomics Scientist, Department of Plant Sciences, University of Tennessee, Knoxville, TN

2001 – 2004: Microarray Core Manager, Ernest Gallo Clinic & Research CenterUniversity of California, San Francisco, CA

2000 – 2001: Senior Research Associate, BASF Plant Sciences LLC, RTP, NC(Promotion to Full Professor Passed College and Departmental Evaluation Unanimously, and the Package is Forwarded to the University Administration)

EducationSungrant Fellow National Renewable Energy Lab 2008Ph.D. Major: Plant Functional Genomics University of Tennessee Dec. 2007

Minor: Statistics M.S. Plant Sciences University of Arizona Aug. 2001B.S. Major: Biology Fudan University Jul. 1997

Minor: International Economics

Research Program (~$10 Million extramural competitive funding as the leading PI)Project Name (for representative projects only) Agency Amount RoleUpgrading Lignin-cointaing Biorefinery Waste for Bioplastics

DOE EERE $2.5 Million PI

Develop Synthetic Crop through Photorespiration Re-channeling and Terpenoid Biosynthesis Optimization,Phase 2

DOE ARPA E $3 Million PI

Synthetic Design of Microorganisms for Lignin Fuel DOE EERE $2.4 Million PIDevelop Synthetic Crop through Photorespiration Re-channeling and Terpenoid Biosynthesis Optimization,Phase 1

DOE ARPA E $1.9 Million PI

Novel Strategy to Improve Plant Biomass by Manipulating PHB Gene Function

Sungrant $69,985 PI

Biodesign of Lignin-Derived Terpene Biofuel State of Texas $150,000 PIStructure Dynamics-Guided Enzyme Improvement Sungrant $34,966 Co-PIManipulating Lipid Profile of Microalgae through Synergistic Chemical Treatment

State of Texas $200,000 PI

National Alliance for Advanced Biofuels and Bioproducts

DOE EERE $166,592 Co-I

Pending:Southern Institute for Bioenergy Sciences (SIBES) DOE OS $70 million PI

Recognition Sigma Delta Gamma Outstanding Graduate Student, 2007 BMC Bioinformatics All Time Most Viewed Article 2012 – 2014, Top Ten Most Viewed Now:

http://old.biomedcentral.com/bmcbioinformatics/mostviewed/alltimeYuan et al., Statistical analysis of realtime PCR

BMC Bioinformatics Most Viewed Article of the Year, in 2011 and 2012:Yuan et al., Statistical analysis of realtime PCR

Insect Science Most Download of the Year of 2011:Shi et al., Molecular approaches to study the insect gut symbiotic microbiota at the ‘omics’age

TeachingBESC489/PLPA689: Genome Informatics, Fall, 2009 – 2017; Evaluation: 4.67/5.00BESC357/PLPA657: Biotechnology for Biofuels and Bioproducts, Spring, 2009 – 2017; Evaluation: 4.34-4.90/5.00

Editorial Positions & Synergistic Activities2016 Session Chair Two Sessions for AICHE Annual Conference2014 – 2015 Review Panel NSF Sustainable Energy2014 Session Chair Special Session in Synthetic Biology,

Society for Industrial Microbiology and Biotechnology, 36th Symposium for Biotechnology for Fuels and Chemicals

2011 – 2015 Review Panel US DOE JGI CSP and Synthetic Biology2011 – 2013 Board of Director MidSouth Comp Biol & Bioinformatics Society2008 – now BMC Research Notes Associate Editor2009 US-China Bioenergy Forum Co-Chair2010 Biofuels Guest Editor for Special Issue

Peer-Reviewed Publications (Corresponding or Co-Corresponding author marked with *) 1. Xin Wang, Changpeng Xin, Wei Liu, Yi Zheng, Runzhe Li, Susie Y. Dai, Xinguang Zhu, Peter

Rentzepis, Joshua S. Yuan*, Enhanced limonene production in cyanobacteria revealsphotosynthesis limitations, Proceedings of National Academy of Sciences, USA, In press.

2. Shangxian Xie; Qining Sun, Yunqiao Pu, Furong Lin, Su Sun, Xin Wang, Arthur J.Ragauskas, Joshua S. Yuan*, Advanced chemical design for efficient lignin bioconversion,ACS Sustainable Chemistry & Engineering, In press.

3. Runze Li, Jie Chen, Tom C. Cesario, Xin Wang, Joshua S. Yuan, Peter M. RentzepisSynergistic reaction of silver nitrate, silver nanoparticles, and methylene blue againstbacteria, Proceedings of the National Academy of Sciences, USA, In press.

http://old.biomedcentral.com/bmcbioinformatics/mostviewed/alltime

4. Hasan Sadeghifar, Tyrone Wells, Rosemary K. Le, Fatemeh Sadeghifar, Joshua S. Yuan,Arthur J. Ragauskas, Fractionation of organosolv lignin using acetone: water and propertiesof the obtained fractions, ACS Sustainable Chemistry & Engineering, In press.

5. Gaia Pigna, Taniya Dhillon, Elizabeth M Dlugosz, Joshua S Yuan, Connor Gorman, PieroMorandini, Scott C Lenaghan, C Neal Stewart, Methods for suspension culture, protoplastextraction, and transformation of high biomass yielding perennial grass Arundo donax,Biotechnology Journal, In press.

6. Yan Shi, Qiang Li, Xin Wang, Shangxian Xie, Liyuan Cai, Joshua S. Yuan*, Directedbioconversion of Kraft lignin to polyhydroxyalkanoate by Cupriavidus basilensis B-8 withoutany pretreatment, Process Biochemistry, In press.

7. Tyron Wells Jr., Rosemary K. Le, Parthapratim Das, Xianzhi Meng, Ryan Stocklosa, AditaBhalla, David B. Hodge, Joshua S. Yuan and arthu J. Raguaskas, Conversion of cornstover alkaline pre-treatment waste streams into biodiesel via rhodococci, RSC Advances, Inpress.

8. Clifford J Unkefer, Richard T Sayre, Jon K Magnuson, Daniel B Anderson, Ivan Baxter, Ian KBlaby, Judith K Brown, Michael Carleton, Rose Ann Cattolico, Taraka Dale, Timothy PDevarenne, C Meghan Downes, Susan K Dutcher, David T Fox, Ursula Goodenough, JanJaworski, Jonathan E Holladay, David M Kramer, Andrew T Koppisch, Mary S Lipton,Babetta L Marrone, Margaret McCormick, István Molnár, John B Mott, Kimberly L Ogden,Ellen A Panisko, Matteo Pellegrini, Juergen Polle, James W Richardson, Martin Sabarsky,Shawn R Starkenburg, Gary D Stormo, Munehiro Teshima, Scott N Twary, Pat J Unkefer,Joshua S Yuan, José A Olivares, Review of the algal biology program within the NationalAlliance for Advanced Biofuels and Bioproducts, Algal Research, 2016, In Press.

9. Elise van Buskirk, Jin Su, Ian Silverman, Sager Gosai, Brian Gregory, Joshua S. Yuan,Henry Daniell, Terpene metabolic engineering via nuclear or chloroplast genomesprofoundly and globally impacts off-target pathways through metabolite signaling, PlantBiotechnology Journal, 2016, 14, 1862–1875.

10. Lu Lin, Yanbing Cheng, Yunqiao Pu, Su Sun, Xiao Li, Mingjie Jin, Elizabeth A. Pierson,Dennis Gross, Bruce E. Dale, Susie Y. Dai, Arthur J. Ragauskas, Joshua S. Yuan*,Systems biology-guided biodesign of consolidated lignin conversion, Green Chemistry,2016, 18, 5536-5547.

11. Xueyan Chen, Ugur Uzuner, Man Li, Weibing Shi, Joshua S. Yuan, Susie Y. Dai,Phytoestrogens and Mycoestrogens Induce Signature Structure Dynamics Changes onEstrogen Receptor α, International Journal of Environmental Research and Public Health,2016, 13 (9), 869

HONGBIN ZHANG (H.-B. ZHANG) Professor of Plant Genomics and Systems Biology

Dept. of Soil and Crop Sciences, Texas A&M University, College Station, Texas

Education/Training 1990 PhD Genetics, University of California, Davis 1984 MS Genetics, Chinese Academy of Agricultural Sciences, Beijing, China 1982 BS Plant Genetics and Breeding, Agricultural University of Hebei, Hebei, China

Positions and Employment 2006- Professor, Dept. of Soil and Crop Sciences, Texas A&M University 2002-2005 Associate Professor, Dept. of Soil and Crop Sciences, Texas A&M University 1996-2001 Assistant Professor, Dept. of Soil and Crop Sciences, Texas A&M University 1994-1995 Assistant Research Scientist, Dept. of Soil and Crop Sciences, Texas A&M University 1992-1994 Postdoctoral Associate, Dept. of Soil and Crop Sciences, Texas A&M University 1991-1992 Postdoctoral Associate, Dept. of Agronomy, University of California, Davis 1987-1990 Research Assistant, Dept. of Agronomy, University of California, Davis

Program Overview My research is focused on genomics and systems biology in crop plants, particularly development of genomic and systems biological knowledge and new or advanced technologies for enhanced crop research and breeding. These include re-establishing of the molecular basis and mechanisms of genetics and biology; cloning and characterization of genes and quantitative trait loci (QTLs) controlling traits of agronomic importance; deciphering of the molecular mechanisms of biological phenomena or traits of importance such as quantitative genetics, epigenetics, crop yield, crop quality, heterosis and plant polyploidization; and development of molecular toolkits and associated pipelines for next-generation enhanced crop breeding such as gene-based breeding and crop production such as molecular precision agriculture. I currently teach two graduate courses in genomics and systems biology (SCSC 654 and SCSC 655) crossed linked with three intercollege programs, GENE (Genetics), MEPS (Molecular and Environmental Plant Science) and BIOT (Professional Program in Biotechnology).

Significant 5 Year Accomplishments Research: Acquired $4,256,621 of which $2,751,289 went to my research program. Discovered and established the DNA “Jigsaw Puzzle” Structure Model as the molecular basis of biology and genetics, thus laying the foundation of observed genetic variation, diversity, abundance and complexity of all organisms; discovered and tested four core molecular mechanisms of biology, genetics and breeding, including content variation, position and array, interaction and network, and modification/mutation (including the traditional gene mutation) of fundamental function elements constituting the genome of an organism; helped establish systems biology and systems genomics in crop plants - Development of a high-throughput gene/QTL cloning system, large-scale cloning of genes and QTLs controlling the traits important to agriculture in major U.S. crops and deciphering of the molecular mechanisms of quantitative genetics, epigenetics, heterosis, crop yield, crop quality and plant polyploidization; and developing a novel plant breeding system - the gene-based breeding system, and a novel crop production system - the molecular precision agriculture system in crops. In addition, led and helped de-novo sequence the genomes of cassava and upland cotton, sequenced and profiled the transcriptomes for 794 cotton, maize, wheat, chickpea and soybean lines, and RAD-sequenced the genomes of 749 cotton, cowpea and rice lines.Teaching: Instructed the SCSC 655 graduate course annually; developed and taught the SCSC 654 graduate course annually; supervised 2 postdoctoral research associates, 8 graduate students, 2 research scientists and 11 visiting scientists; served in graduate committees for 23 students.

Ten Most Recent Publications (116 total and 22 in review or preparation)

1. Zhang H-B, Zhang MP, Liu Y-H, Smith CW, Murray CM, Xu WW, 2015. Concepts, strategies andmethods for genome-wide high-throughput cloning of genes controlling quantitative traits (disclosure).

2. van Oss R, Abbo S, Eshed R, Sherman A, Coyne C, Vandemark G, Zhang H-B, Peleg Z. 2015. Geneticrelationship in Cicer sp. expose evidence for geneflow between the cultigen and its wild progenitor.PLoS ONE 10: e0139789.

3. Zhang MP, Rong Y, Lee M-K, Zhang Y, Stelly DM, Zhang H-B. 2015. Phylogenetic analysis ofGossypium L. using restriction fragment length polymorphism of repeated sequences. MolecularGenetics and Genomics 290:1859–1872.

4. Wang W, et al. 2014. Cassava genome from a wild ancestor to cultivated varieties. NatureCommunications 5:5110.

5. Liu Y-H, Zhang MP, Huang JJ, Zhang H-B. 2014. DNA is structured as a linear “Jigsaw Puzzle” in thegenomes of Arabidopsis, rice and budding yeast. Genome 57:9-19.

6. Qin J, Scheuring CF, Wei G, Zhi H, Zhang, MP, Huang JJ, Zhou X, Galbraith DW, Zhang H-B. 2013.Identification and characterization of a repertoire of genes differentially expressed in developing topear shoots between a superior hybrid and its parental inbreds in Zea mays L. Molecular Genetics andGenomics 288:691-705.

7. Lee M-K, Zhang Y, Zhang MP, Goebel M, Kim HJ, Triplett BA, Stelly DM, Zhang H-B. 2013.Construction of a plant-transformation-component BIBAC library and genome sequence analysis ofpolyploid Upland cotton (Gossypium hirsutum L.). BMC Genomics 14:208.

8. Zhang MP, Zhang Y, Huang JJ, Lee M-K, Zhang XJ, Stelly DM, Zhang H-B. 2012. Physical mappingof polyploid genomes: A BIBAC physical map of allotetraploid Upland cotton. PLoS ONE 7(3):e33644.

9. Zhang MP, Zhang Y, Scheuring CF, Wu C-C, Dong JJ, Zhang H-B. 2012. Preparation of megabase-sized DNA from a variety of organisms using the nuclei method for advanced genomics research.Nature Protocols 7:467-478.

10. Zhang H-B, Scheuring CF, Zhang MP, Zhang Y, Wu C-C, Dong JJ, Li Y. 2012. Construction ofBIBAC and BAC libraries from a variety of organisms for advanced genomics research. NatureProtocols 7:479-499.

Awards and Honors Jastro-Shields Research Awards, 1988. Research Assistantship, University of California, Davis, 1988-1990. Tuition Fee Fellowship, University of California, Davis, 1988-1990. Honorary, adjunct or distinguished adjunct professorships in nine international research organizations

or institutions, 1994 – present.

Professional Experience Advised/co-advised 13 postdoctoral associates, 9 PhD students, 14 MS students, 13 BS students, and

64 visiting scholars. Authored/co-authored 116 peer-reviewed journal articles, 4 books, 11 book chapters, 1 Encyclopedia

section, 22 manuscripts currently in review or preparation and 190 scientific conferenceabstracts/presentations; 112 invited presentations at international conferences or institutions.

Funds acquired: $23,982,442 in total, of which $9,888,656 went to my research program. Courses instructed: Analysis of Complex Genomes – lectures, 3 credits (SCSC 654); Analysis of

Complex Genomes – Labs, 3 credits (SCSC 655); and 7 international workshops in 1995, 1995, 1997,1999, 2000, 2000, and 2008.

Professional service: Editor-in-Chief for 2 international professional journals; associate editor oreditorial board member for eight international professional journals; ad hoc reviewers for 33international journals; proposal panel service for three national or international funding agencies andproposal ad hoc reviewers for USA, Sweden, Netherlands, Germany, China, Spain, France and Russia.