Accelerating Pharma IP Discovery using Advanced Search Technology

Craig Stephens

CAS Vice President, Sales

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.2

Agenda

● Introduction to Chemical Abstracts Service (CAS)

● Trends in chemical research publications

● Prodrugs - a Case Study

Wednesday, April 19, 2023

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.3

CAS is the leading global source of chemical information for scientific and patent research

• Founded in 1907 to monitor, abstract, and index the world's chemistry-related literature and make it available to the scientific community

• Headquartered in Columbus, Ohio

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.4

CAS databases provide complete access to the world of chemistry and related science

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.5

CAS analyzes global chemical information, including extensive coverage of patents from Asia

India (IN)India (IN)India (IN)India (IN)

China (CN)China (CN)China (CN)China (CN)

Singapore (SG)Singapore (SG)Singapore (SG)Singapore (SG)

Republic of Korea (KRRepublic of Korea (KR))Republic of Korea (KRRepublic of Korea (KR))

Philippines (PH)Philippines (PH)Philippines (PH)Philippines (PH)

Taiwan (TW)Taiwan (TW)Taiwan (TW)Taiwan (TW)

Hong Kong (HK)Hong Kong (HK)Hong Kong (HK)Hong Kong (HK)

Japanese Patent Office (JPOJapanese Patent Office (JPO))Japanese Patent Office (JPOJapanese Patent Office (JPO))

Coming SoonMalaysia!

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.6

CAS products streamline access to CAS databases to speed the pace of scientific discovery

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.7

April 19, 2023

Patenting of new chemical research has accelerated, especially patenting of Chinese chemical research

Chemistry Patent Publications, 1999-present

0

20,000

40,000

60,000

80,000

100,000

120,000

1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010

Docu

men

ts in

CAS

Dat

abas

es

China Japan USA WIPO

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.8

Increasingly, new chemical discoveries are being disclosed through patent activities

Per

cen

tag

e o

f to

tal

Percentage of New Compounds Added to CAS REGISTRY from Patents

Year

14%

46%

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.9

How has nanotechnology been used in the area of drug delivery?

Which pharmaceutical companies are developing prodrugs and what technologies are they using?

“Patinformatics” is an emerging science that derives the “big picture” from a multitude of patent documents

Wednesday, April 19, 2023

Ideas

Opportunities

Strategy

Broad SearchBroad SearchStrategyStrategy

Searcher Searcher AnalystAnalyst

QueryQuery Large Large Answer SetAnswer Set VisualizeVisualize DiscoveryDiscovery

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.10

Patinformatics: A quick study on Prodrugs

● Use search tools to create a document set: STN

● Export the document set to an analysis tool

● Perform analysis and visualization within STN AnaVist

– Automatically creates visualizations that are dynamically linked

– Enables evaluation based on comparisons of structured and unstructured data

● Apply the results to a business situation

Wednesday, April 19, 2023

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.11

Search technology can reveal new trends in drug discovery

Search tools ensure comprehensive retrieval of appropriate records

– Controlled Term thesauri focus on targeted terminology used in a database

– Substance search tools include structure and sequence search capabilities

Results from a technical database search can demonstrate trends

– Display fields sort information for further investigation

– Database tools facilitate in-depth analysis and visualization

April 19, 2023

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.12

A thesaurus provides insight into pharmaceutical terminology and a hierarchy to broaden/narrow studies

=> FILE CAPLUS=> E PRODRUGS+ALL/CTE1 0 BT2 Bioactive compounds (non-CA heading)/CTE2 4081 BT2 Health products/CTE3 43159 BT1 Drugs/CTE4 4081 BT3 Health products/CTE5 200542 BT2 Drug delivery systems/CTE6 0 BT1 Pharmaceutical dosage forms (non-CA heading)/CTE7 5509 --> Prodrugs/CT HNTE Valid heading during volume 146 (2007) to present. NOTE A compound that must undergo chemical conversion to a pharmacologically active form after administration.E8 OLD Drug delivery systems (L) prodrugs/CTE9 OLD Pharmaceutical dosage forms (L) prodrugs/CTE10 OLD Pharmaceuticals (L) prodrugs/CTE11 UF DDS prodrugs/CTE12 UF Drug precursors/CTE13 UF Pharmaceutical prodrug/CTE14 UF Pharmaceutical prodrugs/CTE15 UF Prodrugs pharmaceuticals/CT********** END **********

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.13

Modern technology helps develop interactive visualization tools to speed drug discovery

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.14

The Research Landscape reveals the “big picture” in technology development

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.15

Competitive trends in pharmaceutical research can be discovered and explored in more depth

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.16

Summary

● Scientific databases (CAplus) provide easy access to the rapidly increasing amount of prior art in the pharmaceutical area

● Search products (STN) provide a powerful tool to precisely obtain relevant patent information

● Analysis and visualization software (STN AnaVist) facilitate business decisions by:

● Accurately interpreting technological trends

● Identifying leading companies in drug development

● Locating relevant prior art

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.17

“STN offers all important scientific databases we need. This allows comprehensive state-of-the-art searches on all our research topics.”

Dr. Bernhard Hostettler, Head of Intellectual Property Management, Prionics, Swiss Animal Health Diagnostic Company

Discover new Discover new opportunitiesopportunities

Reduce riskReduce riskImprove Improve decision-makingdecision-making

Increase workflow Increase workflow efficiency efficiency

Right information for right business & project decisions

STN can help STN can help leverage your IP leverage your IP

portfolio! portfolio!

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.18

The world’s major pharmaceutical companies trust information from STN

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.19

April 19, 2023

New five-year “single source” contract with USPTO

STN databases offer the largest collection and depth of chemical and related information compared to other commercial web based databases.

… CAS is the only company that has a unique, proprietary, chemical structure searching capability using its STN Express software. No other source can successfully meet the USPTO's requirements.

USPTO, 20 August 2010

“

“

CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.20

April 19, 2023

Thank You.