Fragrance raw materials monographs 279

ACETALDEHYDE ETHYL ISOEUGENYL ACETAL

Synonyms: Acetaldehyde isoeugenyl ethyl acetal; 1-(l-ethoxyethoxy)-2-methoxy-4-(1-propenyl)benzene; isoeugenyl ethyl acetal.

CAS Registry No. 84029-92-5 CAS Index Name: benzene, 1-(l-ethoxyethoxy)-2-methoxy-4-(l-propenyl)-

Structure:

/•OCH (CH3). OCH2" CH3

CH3" CH :CH OCH3

Description: A clear liquid. Occurrence: Has apparently not been reported to occur in nature.

Biological data

Irritation. No irritation was observed after 0.1 ml of the undiluted material was applied to the surface of the rabbit eye (Fritzsche Dodge & Olcott, 1981). No irritation was observed after patch-testing 0.5 ml of the undiluted material to intact and abraded rabbit skin for 24 hr under occlusion (Fritzsche Dodge & Olcott, 1981).

A 48-hr closed-patch test at a concentration of 10% in petrolatum on the backs of 25 volunteers produced no irritation (Fritzsche Dodge & Olcott, 1982).

Sensitization. Tested on guinea-pigs in a delayed hypersensitivity test (Buehler, 1965) with induction and challenge at 25% in corn oil, it produced no sensitization reactions (Fritzsche Dodge & Olcott, 1981).

A maximization test (Kligman, 1966; Kligman & Epstein, 1975) was carried out on 25 volunteers. The material was tested at a concentration of 10% in petrolatum and produced no sensitization reactions (Fritzsche Dodge & Olcott, 1982).

References

Buehler, E. V. (1965). Delayed contact hypersensitivity in the guinea-pig. Archs Derm. 91, 171. Fritzsche Dodge & Olcott, Inc. (1981). Private communication to RIFM, 23 July. Fritzsche Dodge & Olcott, Inc. (1982). Private communication to RIFM, 26 February. Kligman, A. M. (1966). The identification of contact allergens by human assay. III. The maximization test. A procedure

for screening and rating contact sensitizers. J. invest. Derm. 47, 393. Kligman, A. M. & Epstein, W. (1975). Updating the maximization test for identifying contact allergens. Contact Dermatitis

1, 231.