acta medica...
TRANSCRIPT
Acta Medica OkayamaVolume 54, Issue 4 2000 Article 3
AUGUST 2000
Combined use of cellulose acetate polymerand retrievable platinum coils for the
thrombosis of cervical carotid aneurysms.
Nobuyuki Hirotsune∗ Kazushi Kinugasa† Shinya Mandai‡
Koji Tokunaga∗∗ Akira Handa††
Sanami Kawada‡‡ Takashi Ohmoto§
∗Okayama University,†Okayama Rehabilitation Center for Traumatic Apallics,‡Kagawa Prefectual Central Hospital,∗∗Okayama University,††Okayama University,‡‡Okayama University,§Okayama University,
Copyright c©1999 OKAYAMA UNIVERSITY MEDICAL SCHOOL. All rights reserved.
Combined use of cellulose acetate polymerand retrievable platinum coils for the
thrombosis of cervical carotid aneurysms.∗
Nobuyuki Hirotsune, Kazushi Kinugasa, Shinya Mandai, Koji Tokunaga, AkiraHanda, Sanami Kawada, and Takashi Ohmoto
Abstract
Cellulose acetate polymer (CAP) solution is a new liquid embolic material, and it has beenused clinically for the thrombosis of cerebral aneurysms. The purpose of the study was to testa method of aneurysm treatment. In an experimental model, retrievable interlocking detachablecoils (IDCs) were used to create an intraaneurysmal frame or prop and then CAP was injectedinto 20 experimentally induced canine cervical aneurysms. Intraaneurysmal thrombosis was in-duced 1 week after aneurysm creation. Complete thrombosis was attempted in 12 aneurysms, andpartial thrombosis was attempted in 4. Four other aneurysms served as controls. Follow-up an-giography was performed for up to 8 weeks, and with the exception of 4 aneurysms, which werekept for a 2-year long-term follow-up study, the aneurysms were then harvested for histologicalexamination. Thrombosis was successfully achieved in all cases except for 2 enlarged aneurysmsthat were initially partially thrombosed. No thromboembolism to distal vessels was observed. Nocompaction or shift of the CAP-IDC complex occurred even after 2 years. Histologically, CAPand IDCs conformed to the massive thrombotic complex without any fragmentation. By creatinga frame or prop with retrievable microcoils, we were able to inject the CAP implies a comparisonsafely and precisely than has been previously reported. Our findings suggest that this method willbe useful for the treatment of cerebral aneurysms.
KEYWORDS: experimentally induced aneurysm, cellulose acetate polymer (CAP), interlockingdetachable coil (IDC), endovascular technique
∗PMID: 10985175 [PubMed - indexed for MEDLINE]Copyright (C) OKAYAMA UNIVERSITY MEDICAL SCHOOL
1
Hirotsune et al.: Combined use of cellulose acetate polymer and retrievable
Produced by The Berkeley Electronic Press, 2000
2
Acta Medica Okayama, Vol. 54 [2000], Iss. 4, Art. 3
http://escholarship.lib.okayama-u.ac.jp/amo/vol54/iss4/3
3
Hirotsune et al.: Combined use of cellulose acetate polymer and retrievable
Produced by The Berkeley Electronic Press, 2000
4
Acta Medica Okayama, Vol. 54 [2000], Iss. 4, Art. 3
http://escholarship.lib.okayama-u.ac.jp/amo/vol54/iss4/3
5
Hirotsune et al.: Combined use of cellulose acetate polymer and retrievable
Produced by The Berkeley Electronic Press, 2000
6
Acta Medica Okayama, Vol. 54 [2000], Iss. 4, Art. 3
http://escholarship.lib.okayama-u.ac.jp/amo/vol54/iss4/3
7
Hirotsune et al.: Combined use of cellulose acetate polymer and retrievable
Produced by The Berkeley Electronic Press, 2000
8
Acta Medica Okayama, Vol. 54 [2000], Iss. 4, Art. 3
http://escholarship.lib.okayama-u.ac.jp/amo/vol54/iss4/3
9
Hirotsune et al.: Combined use of cellulose acetate polymer and retrievable
Produced by The Berkeley Electronic Press, 2000
10
Acta Medica Okayama, Vol. 54 [2000], Iss. 4, Art. 3
http://escholarship.lib.okayama-u.ac.jp/amo/vol54/iss4/3
11
Hirotsune et al.: Combined use of cellulose acetate polymer and retrievable
Produced by The Berkeley Electronic Press, 2000
12
Acta Medica Okayama, Vol. 54 [2000], Iss. 4, Art. 3
http://escholarship.lib.okayama-u.ac.jp/amo/vol54/iss4/3