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Acta Medica OkayamaVolume 6, Issue 2 1938 Article 9
JULI 1939
Contribution to the Study of VeratrineContraction, with Special Reference to the
Action of Quinine.
Yosio Miyake∗
∗Okayama University,
Copyright c©1999 OKAYAMA UNIVERSITY MEDICAL SCHOOL. All rights reserved.
Contribution to the Study of VeratrineContraction, with Special Reference to the
Action of Quinine.∗
Yosio Miyake
Abstract
In this investigation, the veratrine contraction was studied with special reference to the ac-tion of quinine, and from the results obtained, the following summary and conclusion are made1.Various forms of veratrine contraction were found to be different representations of twitch andveratrine components, corresponding to the concentration of the drug, duration of the action of thedrug (time factor), intensity and frequency of stimulations and individual sensitivity of muscles.2. Veratrine-like contractions were evoked by glycerine and formaldehyde. 3. Veratrine contrac-tion was obviated by lowering the temperature and facilitated by raising it. An intimate relationsbetween the effective minimal dosis of veratrine and temperature were noted. 4. Veratrine contrac-tion was depressed or abolished by calcium or potassium chlorides. Relations between thresholdconcentration of veratrine and calcium or potassium chlorides were determined. 5. Acidity in-hibited the occurrence of veratrine contraction, alkalinity facilitated it. 6. Height of contractionof veratrinised muscle was higher than normal muscle, in twitch as welt as in tetanus. Refractoryperiod of veratrine muscle was greatly prolonged and found in the descending phase of veratrinecontraction. 7. Quinine obviated veratrine contraction. Veratrine-quinine equilibrium ratio wasdetermined. 8. Atropine inhibited the action of veratrine on muscle. 9. Ergotoxine retarded ordepressed the occurrence of veratrine contraction, when applied previously, while if applied after-wards, it exaggerated at first, then alleviated gradually veratrine contraction. 10. Acetylcholinehad no effect on veratrine contraction. Eserine, like atropine, inhibited veratrine contraction. 11.Adrenaline caused complete dissociation of twitch and veratrine components. 12. Monoiodoaceticacid had no effect on the occurrence of veratrine contraction. 13. Veratrine had no effect onisolated frog’s heart. 14. Veratrine caused increased tonicity and irregular tonic contraction onnon-striated muscles (dorsal muscle of leech, intestine and uterus of guinea-pig).
∗Copyright (C) OKAYAMA UNIVERSITY MEDICAL SCHOOL
1
Miyake: Contribution to the Study of Veratrine Contraction, with Special
Produced by The Berkeley Electronic Press, 1938
2
Acta Medica Okayama, Vol. 6 [1938], Iss. 2, Art. 9
http://escholarship.lib.okayama-u.ac.jp/amo/vol6/iss2/9
3
Miyake: Contribution to the Study of Veratrine Contraction, with Special
Produced by The Berkeley Electronic Press, 1938
4
Acta Medica Okayama, Vol. 6 [1938], Iss. 2, Art. 9
http://escholarship.lib.okayama-u.ac.jp/amo/vol6/iss2/9
5
Miyake: Contribution to the Study of Veratrine Contraction, with Special
Produced by The Berkeley Electronic Press, 1938
6
Acta Medica Okayama, Vol. 6 [1938], Iss. 2, Art. 9
http://escholarship.lib.okayama-u.ac.jp/amo/vol6/iss2/9
7
Miyake: Contribution to the Study of Veratrine Contraction, with Special
Produced by The Berkeley Electronic Press, 1938
8
Acta Medica Okayama, Vol. 6 [1938], Iss. 2, Art. 9
http://escholarship.lib.okayama-u.ac.jp/amo/vol6/iss2/9
9
Miyake: Contribution to the Study of Veratrine Contraction, with Special
Produced by The Berkeley Electronic Press, 1938
10
Acta Medica Okayama, Vol. 6 [1938], Iss. 2, Art. 9
http://escholarship.lib.okayama-u.ac.jp/amo/vol6/iss2/9
11
Miyake: Contribution to the Study of Veratrine Contraction, with Special
Produced by The Berkeley Electronic Press, 1938
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Acta Medica Okayama, Vol. 6 [1938], Iss. 2, Art. 9
http://escholarship.lib.okayama-u.ac.jp/amo/vol6/iss2/9
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Miyake: Contribution to the Study of Veratrine Contraction, with Special
Produced by The Berkeley Electronic Press, 1938
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Acta Medica Okayama, Vol. 6 [1938], Iss. 2, Art. 9
http://escholarship.lib.okayama-u.ac.jp/amo/vol6/iss2/9
15
Miyake: Contribution to the Study of Veratrine Contraction, with Special
Produced by The Berkeley Electronic Press, 1938
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Acta Medica Okayama, Vol. 6 [1938], Iss. 2, Art. 9
http://escholarship.lib.okayama-u.ac.jp/amo/vol6/iss2/9
17
Miyake: Contribution to the Study of Veratrine Contraction, with Special
Produced by The Berkeley Electronic Press, 1938
18
Acta Medica Okayama, Vol. 6 [1938], Iss. 2, Art. 9
http://escholarship.lib.okayama-u.ac.jp/amo/vol6/iss2/9
19
Miyake: Contribution to the Study of Veratrine Contraction, with Special
Produced by The Berkeley Electronic Press, 1938
20
Acta Medica Okayama, Vol. 6 [1938], Iss. 2, Art. 9
http://escholarship.lib.okayama-u.ac.jp/amo/vol6/iss2/9
21
Miyake: Contribution to the Study of Veratrine Contraction, with Special
Produced by The Berkeley Electronic Press, 1938
22
Acta Medica Okayama, Vol. 6 [1938], Iss. 2, Art. 9
http://escholarship.lib.okayama-u.ac.jp/amo/vol6/iss2/9
23
Miyake: Contribution to the Study of Veratrine Contraction, with Special
Produced by The Berkeley Electronic Press, 1938
24
Acta Medica Okayama, Vol. 6 [1938], Iss. 2, Art. 9
http://escholarship.lib.okayama-u.ac.jp/amo/vol6/iss2/9
25
Miyake: Contribution to the Study of Veratrine Contraction, with Special
Produced by The Berkeley Electronic Press, 1938
26
Acta Medica Okayama, Vol. 6 [1938], Iss. 2, Art. 9
http://escholarship.lib.okayama-u.ac.jp/amo/vol6/iss2/9
27
Miyake: Contribution to the Study of Veratrine Contraction, with Special
Produced by The Berkeley Electronic Press, 1938
28
Acta Medica Okayama, Vol. 6 [1938], Iss. 2, Art. 9
http://escholarship.lib.okayama-u.ac.jp/amo/vol6/iss2/9
29
Miyake: Contribution to the Study of Veratrine Contraction, with Special
Produced by The Berkeley Electronic Press, 1938
30
Acta Medica Okayama, Vol. 6 [1938], Iss. 2, Art. 9
http://escholarship.lib.okayama-u.ac.jp/amo/vol6/iss2/9
31
Miyake: Contribution to the Study of Veratrine Contraction, with Special
Produced by The Berkeley Electronic Press, 1938
32
Acta Medica Okayama, Vol. 6 [1938], Iss. 2, Art. 9
http://escholarship.lib.okayama-u.ac.jp/amo/vol6/iss2/9
33
Miyake: Contribution to the Study of Veratrine Contraction, with Special
Produced by The Berkeley Electronic Press, 1938
34
Acta Medica Okayama, Vol. 6 [1938], Iss. 2, Art. 9
http://escholarship.lib.okayama-u.ac.jp/amo/vol6/iss2/9
35
Miyake: Contribution to the Study of Veratrine Contraction, with Special
Produced by The Berkeley Electronic Press, 1938