ACUTE MYOCARDIAL INFARCTION STUDY

AMI RESULTS PRESENTED American College of Cardiology – Chicago – 2012

Switzerland (version of FDA) SWISSMEDIC

University of CHUV – Switzerland

Several leading cardiologists & hospitals in US & Europe

Efficacy Data

2

Parameters Experimental Group (N = 19) Control Group (N = 15)Day 1 3 months 6 months Day 1 3 months 6 months

С-Reactive Protein

(mg/mL)

29.9 2.8† 3.6‡ 17.3 14.5 9.2*

(44.7) (1.8) (2.1) (11.3) (6.0) (5.0)

BNP (ng/mL)1731.5 349.6† 186.6‡* 2933.4 1726.6† 946.2‡

(1746.3) (214.4) (110.8) (2457.5) (1205.5) (1028.5)End-diastolic

volume of left ventricle

(mL)

128.1 121.2† 120.1 110.8 110.2 120.2

(43.4) (38.0) (36.2) (28.0) (19.9) (40.3)

End-systolic volume of

left ventricle (mL)

77.1 62.6† 58.3‡ 66.2 59.2 66.8

(38.4) (27.7) (24.3) (39.0) (18.0) (27.4)

Left Ventricular

Ejection Fraction (%)

38.4 52.3† 54.7‡* 38.5 42.8† 46.1‡*

(6.8) (6.8) (5.3) (3.8) (3.1) (5.3)

Mean †: statistically significant, day 1 vs 3 months(Standard Deviation) ‡ statistically significant, day 1 vs 6 months

* statistically significant, 3 months vs 6 months

MRI ResultsPatients: 63 years Diagnosis: AMI (STEMI)Single artery occlusion (LAD) with stenting of infarct related artery

Before After 1months

Treatment of Diabetes II complicationPatients 56 years old with Diabetes II (15 years)

Complication: Atherosclerosis. Occlusion of Femoral Artery

Before After

Treatment of Diabetes II complicationsPatients 61 years old with Diabetes II (20 years)

Complication: Atherosclerosis. Occlusion of Femoral Artery

Before After