acute respiratory distress syndrome it’s so shocking, i can’t breathe! heidi ditmyer dvm...
TRANSCRIPT
Acute Respiratory Distress Acute Respiratory Distress SyndromeSyndrome
It’s so shocking, I can’t It’s so shocking, I can’t breathe!breathe!
Heidi Ditmyer DVMHeidi Ditmyer DVMUniversity of TennesseeUniversity of Tennessee
College of Veterinary MedicineCollege of Veterinary MedicineDepartment of PathobiologyDepartment of Pathobiology
Tifton 2008Tifton 2008Presented at SEVPAC 2008 – Presented at SEVPAC 2008 – Permission granted for use on Permission granted for use on
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SignalmentSignalment Juvenile Female Spayed Yorkshire Juvenile Female Spayed Yorkshire
TerrierTerrier
Presented to rDVM after chewing Presented to rDVM after chewing electric cordelectric cord
rDVM treated with Oxygen and rDVM treated with Oxygen and diureticsdiuretics
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Case 07-796Case 07-796 Referred to UT Referred to UT
VentilatorVentilator
FebrileFebrile
Died 24 hours post arrivalDied 24 hours post arrival
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Gross FindingsGross Findings
Glossal and gingival ulcerationGlossal and gingival ulceration
Bilateral interstitial pneumoniaBilateral interstitial pneumonia
Congenital portosystemic shunt Congenital portosystemic shunt
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Glossal ulceration Glossal ulceration
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Histology and etiologyHistology and etiology
Fibrinous interstitial pneumoniaFibrinous interstitial pneumonia
Multiple possibilitiesMultiple possibilities
Consistent with Acute Respiratory Consistent with Acute Respiratory Distress SyndromeDistress Syndrome
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Acute Respiratory Distress Acute Respiratory Distress Syndrome (ARDS)Syndrome (ARDS)
Acute onsetAcute onset
Bilateral/diffuse pulmonary changesBilateral/diffuse pulmonary changes
HypoxemiaHypoxemia
No evidence of left atrial hypertensionNo evidence of left atrial hypertensionPresented at SEVPAC 2008 – Presented at SEVPAC 2008 – Permission granted for use on Permission granted for use on
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ARDSARDS Secondary inflammatory responseSecondary inflammatory response
Macrophages Macrophages cytokines cytokines enzymes enzymes free radicals free radicals diffuse diffuse alveolar and endothelial damagealveolar and endothelial damage
Differential diagnosis for any animal Differential diagnosis for any animal with non-cardiogenic pulmonary with non-cardiogenic pulmonary edema and appropriate risk factorsedema and appropriate risk factors
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ConclusionConclusion
Limited lung response regardless of Limited lung response regardless of triggertrigger
Overzealous inflammatory responseOverzealous inflammatory response
Pathophysiology not entirely Pathophysiology not entirely understoodunderstood
Considered as differential diagnosisConsidered as differential diagnosisPresented at SEVPAC 2008 – Presented at SEVPAC 2008 – Permission granted for use on Permission granted for use on
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AcknowledgementsAcknowledgements
Dr Kim NewkirkDr Kim Newkirk
UT histology staffUT histology staff
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Thank youThank you
www.k9station.com
Questions?Questions?Presented at SEVPAC 2008 – Presented at SEVPAC 2008 – Permission granted for use on Permission granted for use on
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