ADInstruments Product Overview

Applications• Cardiovascular pressures

• Ventricular pressure-volume

•Bloodflowandcardiacoutput

• Isolated tissue and dose response

• Isolated perfused organs

• ECG and HRV

• Intracellular recording

• Extracellular recording

• Evoked potentials

• Respiration and exercise physiology

Complete solutions for life science researchADInstrumentsresearchsystemsofferflexible,all-in-onesolutionsforyourresearch,includingPowerLabfordataacquisitionandLabChartsoftwareforcomprehensivedataanalysis.Whateversignalsyouwanttomeasure,anADInstrumentssystemcanbecustomizedtorecord,displayandanalyzeyourexperimentaldatawitheaseandaccuracy.

Fast tracking researchDesignedforlifesciences,LabChartwillhelpyoustreamlineyouranalysiswithspecialistmodulessuchasECGAnalysis,BloodPressure,DoseResponse,SpikeHistogram,PeakAnalysisandVideoCapturethatbringallthecalculationsyouneedintooneplace.

Create your complete solutionTailoracompletesolutionforyourresearchapplication.Ourdedicatedteamcanhelpyouchoosefromarangeofsignalconditionersandapplication-specificinstruments,transducersandaccessories.

Take advantage of global supportWhenyourresearchtakesyouplaces,wearetheretohelp.Ourglobalnetworkofofficesanddistributorscoversmorethan80countries,offeringspecialistsupport,technicaladviceandarangeofworkshopsandtrainingcourses.

ProductsOverviewBrochure2017-A4V2-0

Signal conditioners and instrumentsADInstrumentsmanufacturesawiderangeofsoftwarecontrolledpreamplifiersthatareautomaticallyidentifiedandconfiguredbyPowerLab.Allsettingsareautomaticallystoredwithdatafilesforeasyrepeatingofexperiments.

Precision data acquisition

hardware

PowerLabistheoriginalhigh-performancedigitaldataacquisitiondevice,citedinmorethan20,000researchpapersinpeer-reviewedjournals.PowerLabsystemsforresearchprovidethefullutilityofamulti-channel,real-timechartrecorder,polygraph,XYplotter,digitalvoltmeterandstorageoscilloscopewiththebenefitsofeasydatahandling,highresolution,andvariablesamplingspeeds.

PowerLab data acquisition units provide:• 16Bitresolutiononallgainranges

• Variablesamplingandonlinecomputationspeedsofupto200000s/sperchannel(400kHzaggregateacrossallchannelsor2x200kHzontwochannels)

• Fastprocessorforreal-timedataacquisitionwithout data loss

• Integratedpodportsforwideramplifierandtransducer choice

• Digital inputs and outputs for external instrument control and triggering

• AC/DCcoupledinputs

• Independent stimulator outputs

• High-pass,low-passandanti-aliasingfilters

• Availablein4,8or16channels

• SuppliedwithLabChartsoftware

PowerLabissimpletosetup,connectingdirectlytoWindowsandMacintoshcomputersviaUSBport,andisautomaticallydetectedbyLabChart.

Transducers and accessoriesWeofferanextensiveselectionofinstruments,transducersandaccessoriesmadebyADInstrumentsandworld-leadingbrands.ProductsarefullycompatiblewithPowerLabrecordersandsignalconditioners.

World-leading analysis software

WithLabChartanalysissoftware,youcanrecordanddisplayyourdatainrealtime,performingonlinecalculationsathighsamplingrates,givingyoufullcontrolofyourresearch.Recordupto32channelsofrawdataandchoosefromLabChart’srangeofsophisticatedAdd-Onsthatarepurpose-builtforsignalsspecifictolifescience,includingcardiovascular,respiratory,bloodpressure,neuronalanddoseresponsedata.LabChartissimpletouseandsuitableforabroadrangeofsignaltypes.

Dose Response Generatesdoseresponsecurves,EC50valuesandadditionalparameters

Metabolic Provides real-time measurements of parameters such as VCO2,VO2,VE and RER

Blood Pressure Automaticallydetects,analyzesandreportsparametersfromarterialorventricularpressurerecordings

SpikeHistogram Detects,discriminatesandanalyzesextracellularspikeactivitygeneratingarangeofplotsandstatistics

ECG Analysis Detectsandreportstheonset,amplitudeandintervaltimesofPQRSTfromhumanandanimalECGsignals

Cardiac Output CalculatescardiacoutputfromaLabChartrecordingofathermodilutioncurvemeasuredinanimals

HeartRateVariability DisplaysandanalyzesvariationintheintervalbetweenheartbeatsinhumanandanimalECG

Video Capture AllowsthesynchronizedrecordingandplaybackofaQuickTimemovieandLabChartdatafile

Peak Analysis Automaticdetectionandanalysisofmultiple,butnotoverlapping,signalwaveformsfromrecording

DMTNormalization CalculatesandstandardizesoptimalvesselpretensionconditionsforwiremyographsfromDMT

PVLoop Analyzesleftventricularpressureandvolumedata,calculatesloopareaandawiderangeofhemodynamicparameters

Use LabChart to:• RecordfrommultiplePowerLabsanddevices• Previewandoptimizerecording• Import and export data easily• Annotate data with comments• Convert raw data into useful units• Automate recording and analysis tasks• Change recording settings in seconds• Recall data and experimental settings• Generatecustomizedstimulusoutputs• SpeedupanalysiswithLabChartModules

Specialized analysis with Add-On modules GetthefullsuiteofmoduleswithLabChartPro(somemodulesarenotavailableonMac).Rangeincludes:

LabChartReaderisdownloadablesoftwarethatletsyoushare yourLabChartdatafileswithcolleagues,publishersandstudents. ItenablesanyonetoopenandviewLabChartfilesandincludesanumberofLabChartanalysisanddisplayfeatures.

Research applications

Cardiovascular pressureMikro-Tip BP Foundation SystemProvidestheessentialtoolsformeasuringbloodpressureinsmallandlargeanimals.Includesthelow-drift,highimpedanceinputBridgeAmp,compatiblewithhigh-fidelityMikro-Tip®BPcathetersforresearch,availableexclusivelyfromADInstruments.ThecathetersoperateseamlesslywithLabChart’sBloodPressureModuletodeterminesystolicanddiastolicpressures,dichroticnotch, dP/dtandmore.

Mikro-Tip pressure-volumeSimultaneouslymeasurepressureandvolumeinlargeandsmallanimalswiththeMPVSUltraFoundationSystemandMillarMikro-Tip®PV catheters(selectedseparately).SuppliedwithLabChart’sPVLoopModuleforautomatedcalculationofsystolicanddiastolicpressures, strokevolume,COandmore.Singleandmulti-segmentMikro-TipPVcatheterssuitableforuseinanimals16gandlargeraresuppliedinarangeofsensorsizesandelectrodeconfigurations.Alsosuitableforuseinthedigestiveandreproductivesystems(i.e.bladder,uterus).

Fluid-filled blood pressure transducersDeterminearterialandvenousbloodpressureusingtherangeoffluid-filledpolyethylene,pressuretransducersforusewithsmallandlargeanimals.The transducers are ideal for use with ADInstruments Bridge Amps or the electrically isolated BP Amp thatprovidesBPreadingsinmmHg.TheBPAmpissuitableforusewithhumansubjects.

Non-invasivebloodpressure(NIBP)Human NIBP SystemMonitortrendsinbloodpressurecontinuouslyandnon-invasivelyinhumans.Fingercuffswitchingallowslongsamplingperiodswithminimaldiscomforttosubjects.Providesareconstructedarterialpulsewaveformbasedonafingercuffmeasurement.Cuffsavailableinavarietyofsizes.BasedonFMStechnology.

Animal NIBP SystemDetectsintermittentpressure/pulseforcalculationofsystolicpressureinmiceandrats.Interchangeableautomatedtailandcufftransducersaresupplied.

Blood flow and cardiac outputInvasive measurementsMeasurearterialorvenousflowwithTransonicFlowSystemsandTransonicFlowprobes(availableseparately).Withminimalsignaldriftandattenuation,flowprobesareappropriateforacuteandchronicstudies.Arangeofsizessuitableformiceandlargeranimalsareavailable,aswellasinline/clamp-onsensorsfortubingapplications.

Blood perfusionContinuouslymonitorbloodandperfusionofmicrovascularbedsandrapidlycalculateCardiacOutput(mL/min)withLaserDopplerFlowmetry(LDF)probesandtheBloodFlowMeter(secondanalogoutputcorrectingforBSC).Suitablefor monitoring circulation during surgery and drug or cardiovascularstudies,LDFprobesforskin,muscleandorgansareavailable.

Get a complete solution for applicationsincludingNIBP, bloodflowandcardiacoutput,isolatedtissue,isolatedheart,biopotentials, electrophysiology, microneurography, psychophysiology andmanymore.

Complete research systems

Multi-Channel Bio AmpsQuad,Octalor16channelbioampscanbeusedwithbothchestandresuableelectrodesfordifferentialEEGormultiplebiopotentialmeasurementinasinglesubject.AlsocompatiblewithEEGcaps(availableseparately).

Animal Bio AmpLow-noise,high-gaindifferentialBioAmpsuppliedwithmicro-hookelectrodes.Compatibleneedleorspringclipelectrodes areavailableseparately.

ECG Switch BoxFor mechanical selection of standard lead configurations(10standardleadwires).Idealforvector cardiography as a low cost option for thosewithonlyasingleordualbiotogetafull 12leadECG.TheECGSwitchBoxgivesdirect measurementofleadsI,II,III,aVF,aVL,aVR andV1toV6.

Research applications

Biopotentials ElectricallyisolatedBioAmpsareoptimizedforrecordinghumanandanimalECG,EMG,EEG,ERG,EOG,visualevokedcorticalresponseandmore.PerformpowerfultimeandfrequencydomainanalysisusingLabChart’sCyclicMeasurementsandSpectrumView.

Isolated perfused heartsWorking heart (Radnoti)MeasurehemodynamicparametersinsmallanimalheartswiththeRadnotiworkingheartsystem.Cappedandwater-jacketedtoensureconstantperfusatetemperature,withportsforinsertionofcannulaeandcommonly-usedpacingandECGelectrodes.Withadditionalinstrumentsyoucanmeasureatrialvolumeandcardiacoutput,left-ventricularpressure,pH,temperature,surfaceECGandmore.

Langendorff heart (Radnoti and PanLab)Monitorcardiacfunctionincludingleftventriculardevelopedpressure,HRandmore.Easilyswitchbetweenconstant-pressureandconstant-flowmodes with the convenient pump controller (includedwithsystem).

Isolated tissueAll-in-one compact organ baths (PanLab)Systemsavailablein4,8and16chambersidealforstriated,smoothandcardiacmusclestudies.Featuringelectrovalvesforautomatedfillingandemptyingoftissuechambers,aconstantsystemtemperatureisensuredbyenclosureoftissuevessels,reservoircoilsandtubinginasingletemperature-controlledwaterchamber.Systemsareprovidedwithisometrictransducers,howeverisotonictransducersandstimulatingelectrodesarealsoavailable.

Research applications

Isotonic force transducers

Isolated tissueTraditional organ baths (Radnoti) (left)Radnotimodularorganbathsystemsalloweasysubstitutionofparts,enablinganextensivechoiceoftissuetypesandchambersizes(5to300mL). Thewater-jacketedglasswareandtubingwithheatingcoilsintheorgan/tissuebathsensureconstanttemperaturemaintenancethroughoutthesystemforaccuratestudyofmusclecontraction,doseresponsesandmore(LabChartModulessupplied).

WirelessdatarecordingElectromyography (EMG)Record true freedom of movement using systems withParallel-BarandMotionArtifactSuppressiontechnologiesfromDelsysInc.

SmallandlightweightEMGsensorshavebuilt-intriaxialaccelerometerswithaselectablerangeofg-forces.Upto16sensorscansimultaneouslytransmittherecordedsignalstoasinglereceiver.VariationsoftheEMGsensorssuchasminiEMGandSnap-Leadarealsoavailable.

Other wireless sensors include the EKG sensor for ECGmeasurementsandthe4contactforcesensitiveresistivesensor(FSR)forrelativeforceorpressuredistributionmeasurementsandtimingfrombody-contactsurfaces.

PowerfulfeaturesinLabChartprovideflexibledatadisplay with easy calculations including root mean square(RMS),powerspectraldensity(PSD),andintegration.

Neural recordingADInstrumentsandTriangleBioSystemsInc.(TBSI)provideawaytofasttrackbehavioral-electrophysiological research with industry-leading systemsforwirelessacquisitionofneuraldata.Systemsrecordfieldpotentialsorindividualneuralspikesfromsmallanimals(idealforrodents)usingimplantedmetalelectrodes.

NeuralsignalsaretransmittedbysmalllightweightheadstagesthatareavailablewithoptionssuchasLEDforvideotrackinginmazestudiesorexternalbatteriesforextendedrecordingtime.

ElectrophysiologyReady-to-use neurophysiology research systems,featuringWarnerInstruments’equipment,areidealforin vitro and in vivo applications.TheExtracellularRecordingSystemprovidesaversatile,lownoisedifferentialamplifier.TheIntracellularRecordingSystemprovidessimultaneouscurrent injection stimulation and recording using a singlemicroelectrode.

Systemsareavailablefortwo-electrode,whole-cellvoltageclampingoflargecellsandcellstructures.

Investigatetissuetransepithelialvoltage,shortcircuitcurrent,andmembraneresistanceusingepithelialSingleanddualchannelVoltageClampSystems.

Ussingchambersareavailableseparately,withinsertstosuityourresearchneedsthatcanbeeasilychangedbetweenexperiments.

Patchclampamplifiersofferarangeofresistive-feedbackheadstagesforcurrents±1,10and100nAinwholecellsorsingleionchannels.

MicroneurographyTheNeuroAmpExisalow-noise,high-gaindifferentialamplifierpurpose-builtforamplificationofextracellularsinglecell/tissuepotentialsandsinglenervefiberpotentials(split-nervepreparationorhumanmicroneurography).Electricallyisolatedforhuman connection it is supplied with a headstage andmicroelectrodeadapters.

Research applications

SpirometryandexercisephysiologyTheExercisePhysiologySystemincorporates avarietyofspecializedinstruments,transducersand accessories safe for human connection during exerciseandatrest.

HardwareincludesSpirometer,RespiratoryFlowHeads,GasAnalyzer,GasMixingChamber,ThermistorPod,temperaturesensorandsingle-channelbioamplifier.

MonitorandcalculatehumancardiorespiratoryandmetabolicparameterssuchasRR,volumeandflowrates,VCO2,VO2,VE,RER,intrathoracicpressureandlungsoundswiththeBP,HRV,MetabolicandECGAnalysismodulessupplied.

PsychophysiologyMeasureevokedresponsestovisualandauditorystimuli(VEP,ERPetc.)withacompletesystemthatincorporatesSuperLab®Software,StimTracker®andaccessoriessuchastheResponsePadandSmartVoiceKey(onecomputerisrequiredforstimuluspresentationandanotherfordataacquisition).

Skinconductance/temperature,respiratory,cardiac,andneurophysiologicalresponses,aswellasanalyzereactiontimeandreflexescanalsoberecordedusingoptionaltransducers.

INDUSTRY LEADERSPowerLabistheoriginal,highperformancedigitaldataacquisitionhardware,usedinalloftheTop100institutionsforlifescienceandcitedbymorethan20,000researchpapersinpeer-reviewedjournals.

ENVIRONMENTALLY FRIENDLYStrictmanufacturingprocesses,RoHScompliantparts,lead-freesoldering,anduseofrecycledandrecyclablematerialsensureswemeetourenvironmentalresponsibilities.

QUALITY AND RELIABILITYADInstrumentsproductsarecertifiedtomeetthestrictestinternationalsafetystandardsforhumanandanimaluse,includingtheCEmark.HardwareismanufacturedunderasystemcertifiedtocomplywithISO9001:2008.

DATA INTEGRITYPowerLabdataacquisitionsystemsaretestedandcalibratedtodeliverprecisiondataofthehighestquality.

PROVEN TRACK RECORDWith30yearsofdesignandmanufacturingexperience,wehaveinstalledmorethan45,000PowerLabdataacquisitionsystemsworldwide.

INTUITIVE USEOursoftwareismasteredquicklyandprovidescomprehensiverecording,displayandanalysisfeatures.

POWER AND FLEXIBILITYWhetheranimalorhuman,organ,tissueorcell,invivo,invitroorexvivo,oursystemsareadaptabletoavarietyoflifescienceapplications.

EXCELLENCE IN CUSTOMER TRAINING & SUPPORTOurin-housescientists,educators,programmersandbiomedicalengineersunderstandyourresearchneeds.Withrepresentativesinmorethan80countries,weprovideatrulyglobalsupportnetwork.

EXCLUSIVE DISTRIBUTIONWeofferanexclusiverangeofADInstrumentsandotherbrandproductsincludinggold-standardMillarcardiovascularproductsforresearch.

GLP & 21 CFR PART 11 COMPLIANCEOurGLPsoftwareprovidesadataacquisitionsolutionforGLPand21CFRPart11compliantenvironments.Theyprovideanon-editableaudittrailofallfileoperations,andacentralizeduserandsignatureauthorizationsystemthatverifiesuservalidity.

The ADInstruments advantage

PowerLab,LabChartandLabTutoraretrademarksofADInstrumentsPtyLtd.Allothertrademarksarethepropertyoftheirrespectiveowners.PowerLabsystemsandsignalconditionersmeettheEuropeanEMCdirective.ADInstrumentssignalconditionersforhumanuseareapprovedtotheIEC60601-1patientsafetystandardandmeetinternationalstandards.ISO9001:2008CertifiedQualityManagementSystem. GLP

21CFR Part11Compliance

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