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Assalamualaikum Wr. Wb.

Presented by :

Hafdzi Maulana

Aang Setiawan

Todia Pediatama

ANTI-HYPERTENSIVE AGENT OF CORN SILK EXTRACT AS PREVENTIVE METHOD

IN VASCULAR HYPERTENSIVE DISEASE

[TITLE]

LifestyleRisk Factorx

Background

LifestyleRisk Factor

Vascular HypertensiveDisease

severe

x

1. The Impact of Chronic Disease in Indonesia. Available from : http://www/who/int/chp/chronic_disease_report/en/. 2. Kumar, R., Abbas, A., DeLancey, A., and Malone, E. Robbin and Cotran Pathologic Basis of Disease. ed 8. US. 2010: 529-

585.3. Kasper, Braunwald, Fauci, Hauser, Longo and Jameson. Harrison’s Principles of Internal Medicine. ed 16. US. 2005:

1463-1480.4. Mycek, M.J., Harvey, R.A., and Champe, P.C. Lippincott’s Illustrated Reviews: Pharmacology. ed 2. US. p 157.

Objective

To describe and give basic understanding of corn silk as preventive method in VHD.

Benefit

For future research on providing deeper knowledge for effectiveness of corn silk.

Data Synthesis

Discussion

&

JurnalJurnal

Searching engine

Inclusion

Abstract

Result & Discussion

Keywords :

Output

Analyze

Exclude

Data Synthesis

Jurnal

Corn Silk

•Contain

Hypertension

• Etiology

Corn Silk

Hypertension

1. Taxonomy and Nomenclature of Zea Mays L. 2012; Available from: ttp://www.itis.gov/servlet/SingleRpt/SingleRpt?search_topic=TSN&search_value=422692. Maksimovic, Z., Malencic, D. and Kovacevic, N. (2005) Polyphenol contents and antioxidant activity of Maydis stigma extracts. Bioresource Technology 96, 873-877.

Zea mays

Classification

Morphology

Distribution

Usage

Zea mays or known as corn. From genus Zea L.. Species Zea mays L.(1)

LEAF

EAR

STALK

TASSEL

Corn Silk (maydis Stigma)

COB (kernels)

???

Treatment of Cystits, gout,

nephritis, benign prostatic

hyperplasia (2)

Corn Silk

Hypertension

[25]http://medical-dictionary.thefreedictionary.com/hypertension (10/3/2012)

Hypertension which is unknown cause called primary hypertension (also called essential and idiopathic hypertension), and hypertension which is known cause called secondary hypertension.

[26]Fauci, Anthony., Kasper, Denis., Harrison’s Internal Medicine.Ed.18.USA:McGraw-Hill’s.2009

Classification of Hypertension

[26]

No. Blood Pressure Classification

Systolic Diastolic

1. Normal <120 <80

2. Prehypertension (PH) 120-139 or 80-89

3. Stage 1 hypertension 140-159 or 90-99

4. Stage 2 hypertension ≥160 ≥100

5. Isolated systolic hypertension

≥140 <90

[29,30]

• Moser, Marvin. Heart Book. USA : Yale University. Shijiazhuang Kidney Disease Hospital. http://kidneycn.com (16/03/2012)

Criteria of People in High Risk of Hypertension

Obesity

Improper diet

SmokingLain-lain

Non-pharmacologic[31]

[31]Crawford, Michael. CURRENT Diagnosis & Treatment in CARDIOLOGY. Ed.2. USA: Mac Graw Hill.[32]Antonello, Michele., Montemuro, Domenico., Bolognesi, Massimo., Pasoli, Di Marco., Piva, Anna., Grego, Franco., Sticchi, Danielle., Giuliani, Luisa., Garbisa, Spiridro. and Rossi, Gian Paolo. 2007. Prevention of Hypertension, Cardiovascular Damage & Endothelial Dysfunction with Green Tea Extracts.Italy.[15]Hu Q-L, Deng Z-H. Protective effects of flavonoid from corn silk on oxidative stress induced by exhaustive exercise in mice. African Journal of Biotechnology. 2011;10(16):3163-7.

Non-pharmaco &

Pharmacologic [31]

Green Tea[32] Corn Silk[15]

Treatments

Pharmacologic [31]

Back

High Risk

•Obese •Improper Diet•Diabetes•Smoking, etc.

High blood glucose adipogenesis

High LDL

High cholesterol

Atherosclerosis

Hypertension

Water & Na retention

Flavonoid

Tannic Acid

Fe+ chelating

Flavonoid & Sapponin

Minerals

Discussion

Conclusion

It has several compound and activity as anti-oxidant

agent, anti-inflammation, and anti-hyperlipidemia, that plays as hypertensive agent. Comparing to current preventive method e.g. green tea that works as anti-oxidant, corn silk is more effective to work. It is low-cost, and easy-found.

Further research is considerably recommended in Indonesia. Also, the research in effectiveness of corn silk should be held in future.