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Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

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Page 1: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Advances in Integrated Dual Disorders Treatment

FADAA/FCCM—Annual Conference 2013

Troy Pulas, MDAddiction Psychiatrist

Judy Magnon, RN-BCBS,CAC1

Page 2: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Disclosure• Neither we nor any member of our immediate

families have a financial relationship or interest with any proprietary entity producing health care goods or services related to the content of this CEU activity.

• Our content will not include discussion/reference to commercial products or services.

• We do not intend to discuss an unapproved/investigative use of commercial products/devices. 2

Page 3: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Affiliations• Troy Pulas is an addiction psychiatrist and

medical director for WestBridge South in Brooksville, FL. He was formerly an instructor of psychiatry at Boston University Medical Center.

• Judy Magnon is a board certified psychiatric/mental health nurse and a Florida Certified Addiction Counselor. She is the Program director for WestBridge South in Brooksville, FL.

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Page 4: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Co-Occurring Disorders

Psychiatric Disorders and Substance Abuse are both Brain Disorders.

Both effect Dopamine and Serotonin functioning in the nerve cells. 4

Page 5: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Co-Occurring Disorders

Impaired brain chemistry effects the metabolism of substances, resulting in loss of control, abuse, and/or dependence. Dopamine receptors are effected by alcohol/drug use and this is the same area effected by psychotropic medication. (and Caffeine & Nicotine)

HELP

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Page 6: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

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SUBSTANCE ABUSE/DEPENDENCE IS A

DISEASE

1. It has symptoms(Warning Signs)

2. There is progression(How things get worse)

3. There is a Prognosis(An outcome based on the usual course of the disease)

Page 7: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Rationale for Integrated TreatmentAny Sub. Use Dis.

Any Alcohol use Dis.

Any Drug use Dis.

Psychiatric DX: % % %General Population

16.7 13.5 6.1

Schizophrenia 47% 33.7% 27.5%Bipolar Disorder

56.1% 43.6% 33.6%

Major Depression

27.2 16.5 18

OCD 32.8 24 18.4Phobia 22.9 17.3 11.2Panic Disorder 35.8 28.7 16.7

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Page 8: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Rationale for Integrated Treatment

• Dual disorders orders have worse outcomes:

• Greater symptom relapse and worse adherence to treatment

• More likely to be violent or a victim of violence • Higher rates of homelessness• Higher hospitalization rates and ER utilization• More likely to be incarcerated• More medical problems including HIV and hepatitis

Green 2007 AJP, Drake 2008 JSAT

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Page 9: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Rationale for Integrated Treatment

• Programs that integrate treatment of both illnesses have been shown to be more effective

Think--- 2 broken legs• Parallel treatment has a high

dropout rate, few get both services, poor communication between providers

Green 2007 AJP, Drake 2008 JSAT

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Page 10: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Higher Rates of Psychiatric Relapse For People with Dual Disorders Who Use Substances

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More relapses over time using “pot”

Page 11: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

PARALLELS: Psychosis and Addiction

By Dr. Ken MinkoffAddiction Disease• 1. A biological illness• 2. Hereditary

(In part)• 3. Chronicity• 4. Incurable• 5. Leads to lack of

control of behavior & emotions

• 6. Affects the whole family

Major MI Disease• 1. A biological illness• 2. Hereditary

(In part)• 3. Chronicity• 4. Incurable• 5. Leads to lack of

control of behavior & emotions

• 6. Affects the whole family

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Page 12: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

PARALLELS: Psychosis and Addiction

By Dr. Ken MinkoffAddiction Disease• 7. Symptoms can be

controlled with proper treatment

• 8. Progression of the disease without treatment

• 9. Disease of denial• 10. Facing the disease

can lead to depression and despair

Major MI Disease• 7. Symptoms can be

controlled with proper treatment

• 8. Progression of the disease without treatment

• 9. Disease of denial• 10. Facing the disease

can lead to depression and despair 12

Page 13: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

PARALLELS: Psychosis and Addiction

By Dr. Ken MinkoffAddiction Disease• 11. Disease is often

seen as a “Moral” issue, due to personal weakness rather than biological causes

• 12. Feelings of guilt and failure

• 13. Feelings of shame and stigma

• Physical, mental, and spiritual disease

Major MI Disease• 11. Disease is often

seen as a “Moral” issue, due to personal weakness rather than biological causes

• 12. Feelings of guilt and failure

• 13. Feelings of shame and stigma

• Physical, mental, and spiritual disease

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Page 14: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Parallels--Recovery

• 1. First phase is acute stabilization with medication (Detox/antipsychotic)

• 2. First phase often requires hospitalization

• 3. Following acute stabilization, next phases are prolonged stabilization and rehabilitation.

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Page 15: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Parallels--Recovery

• 4. a. A prerequisite for rehabilitation is

maintaining stabilization by following a long term program:• “Don’t drink”…, Go to meetings,

read literature, etc.• Take meds, attend groups, see

CM/Dr., etc.15

Page 16: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Parallels--Recovery

• 4. b. Once stabilization has been maintained

long enough (usually 1 year) growth and rehabilitation can occur.

• 5. Person must overcome Denial/Disbelief.

• 6. Person must acknowledge powerlessness over the disease

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Page 17: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Parallels--Recovery

• 7. Person must ask for help from a power greater than themselves to control symptoms (Higher Power, AA/NA, Therapist, Meds, etc.)

• 8. Recovery proceeds one day at a time through increasing acceptance of one’s illness and gradually learns better coping skills to cope with

daily reality. 17

Page 18: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Parallels--Recovery

• 9. Recovery is never “complete”, but slow, gradual progress can be made.

• 10.Risk of relapse is always present—need help over time.

• 11.Family must also be involved in a program to get help dealing

with the disease. 18

Page 19: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Parallels--Recovery

• 12.Education about the disease is an important component.

• 13.Treatment must focus on feelings about the disease, and feeling good about oneself with a

disease.• 14.Ultimately, recovery is a physical,

mental, and spiritual process. 19

Page 20: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

IDDT Development

• 1980s: Identification/description of model• Based on PACT Model of Care

• 1990s: Development of integrated treatments• Research started in NH and spread through out

the world• 2000s: Implementation of evidenced based

practices in IDDT• IDDT Manual published by Dartmouth

Psychiatric Research Center—Dr. Robert Drake and team.

Drake 2008 JSAT 20

Page 21: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Integrated vs. Non-Integrated Treatments

*** If current & subsequent points = 1 then the current score = 1Assessment Points Baseline 6 mo. 12 mo. 18 mo. 24 mo. 30 mo. 36 mo.Hi-Fidelity 0 19.67 26.23 29.51 37.7 42.62 55.74Low-Fidelity 0 3.85 3.85 7.69 7.69 15.38 15.38

Figure 1. Percent of Participants in Stable Remission for High-Fidelity ACT Programs (E; n=61) vs. Low-Fidelity ACT Programs (G; n=26).

0

10

20

30

40

50

60

Baseline 6 mo. 12 mo. 18 mo. 24 mo. 30 mo. 36 mo.

Assessment Point

Pe

rce

nt in

Re

mis

sio

n

McHugo 1999 Psych Serv

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Page 22: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Principles of IDDT

• Administered by a multidisciplinary team• Counseling is less confrontational and more

supportive• Comprehensive services• Case management• Residential treatment• Stage-wise interventions

Brunette 2006 J Clin Psychiatry22

Page 23: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Principles of IDDT (continued)

• Supported employment (EBP)• Social support• Rehabilitation or skills training• Flexibility• Long-term perspective• Interventions for non-responders• Assertive Community Treatment (ACT) (EBP)

Brunette 2006 J Clin Psychiatry 23

Page 24: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Stage-wise Treatment

Stage of change Stage of Treatment

Strategies

PrecontemplationContemplationPreparation

Engagement and persuasion

Outreach, Engagement activities (i.e. addressing basic needs)Crisis interventionMotivational interviewingPsychiatric StabilizationMedication, StructureEducation about MH & SAEducation about wellness-nutrition, exercise, smoking, sleepEncourage self help with staff after education and reframing for stageIndividual and Ed. Groups 24

Page 25: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Stage-wise Treatment

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Action Active treatment Self-monitoring, Self-helpSocial skills trainingGroups, CM, CBT programsBuild sober networkContinue to address wellness —nutrition, exercise, sleep, tobacco cessation

Maintenance Relapse prevention

Formulate a plan for relapseExpand recovery to other areas of their lives, use sober networkContinue to address wellness —nutrition, exercise, sleep, tobacco cessation

Page 26: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Assertive Community Treatment and IDDT

• ACT is an evidence-based treatment started in the 1970s to provide treatment and rehabilitation for SMI in Wisconsin

• Multidisciplinary team approach

• Integration of intensive services individualized to each person

• Assertive outreach in the community and to families

• Medication management

• Prescribers meet regularly with the team in a leadership role

• Continuity of care over time

• The ACT model has been adapted successfully for IDDT

Bond 2001 Dis Manage Health Outcomes

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Page 27: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

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IDDTACTIntegrated Dual Disorders Treatment

Assertive

Community Treatment

OVERLAP OF THE MODELS

Focus is on developing motivation for treatment using Stage Wise interventions VS on SX Management & everyday problems;

Based on: Recovery thinking, individual choice, shared decision making, and the individual drives TX.

ACT & IDDT equals addressing all areas.

Page 28: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

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Four Quadrant Model

MI High

SA High

MI Low

SA High

High

S

A

M I Low

Q IV Q III

Q II Q1

LOW

MI High

SA Low

MI Low

SA Low

Severity

S

E

V

E

R

I

T

Y

High

K. Minkoff

Page 29: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

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STAFF-- NEEDED ABILITIES

• To be able to NOT take person’s anger personally

• To not join/align with the illness(s) and enable client to use

• To advocate with them to take the medications (Or unable to participate in TX offered)

• To understand Stages of Change/Motivational Interviewing

Page 30: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

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STAFF-- NEEDED ABILITIES• To use Baker Act, Marchman Act,

Payeeship, guardianship and any other tools as needed to ensure care

• To develop a long term relationship• Work with families, S/O,

Partners,police, guardians, lawyers, physicians, etc.

• To understand the consequences of person’s use of substances

Page 31: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

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STAFF-- NEEDED ABILITIES

• To understand:• Recovery is a slow process with ups and

downs• Recovery is not an event• Treatment is like Insulin—without it, the

illness returns and progression is faster with worse physical and mental damage

• The Family is not to blame and neither is the Participant. We do not blame for Cancer.

Page 32: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

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STAFF-- NEEDED ABILITIES

• To have compassion for the illness

• Have a commitment to this Population

• Have knowledge of:• MI & SA, Sexual Abuse issues, medical issues, PTSD, Personality Disorders, medications, documentation, etc.

Page 33: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

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STAFF-- NEEDED ABILITIES

• Ability to be a team player• Able to communicate effectively to all

team members, especially with the participant & family

• Able to partner with person in treatment, instead of as the “expert”

• Able to carry the hope for the person, until they are ready to take it back.

Page 34: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

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BASED ON: Recovery Thinking

The person’s illness(s) is not all they are.

(EXAMPLE—Judy is a person who experiences Schizophrenia instead of Judy is Schizophrenic.) (Just like experiencing Diabetes)

Page 35: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

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BASED ON:Recovery Thinking (Continued)

The person is a partner in the treatment process and

The provider is a guide with knowledge and clinical experience to share, discuss, educate, explore, coach, advise, assist, encourage, negotiate, role model, validate, etc.

Page 36: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

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BASED ON:Recovery Thinking (Continued)EXPECT THEY WILL IMPROVE/RECOVER!!!!!!!!!!!

Celebrate the successes, no matter how small,

Use positive language in meetings and in day to day job tasks to practice the recovery way of thinking,

EMPOWERMENT: Offer choices, clarify they have the power to make choices/decisions,

You are offering tools, and they can choose to use them or not. You hope they will, but you respect their choice to not be ready yet.

Page 37: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

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BASED ON:Recovery Thinking (Continued)

No matter what level of illness—Expect that they can participate at some point in “Meaningful Day time Activity”

WORK is Therapy!!!!!!

They do not have to be sober to work. (Clinical evidence shows that some people will stop using to keep a job!)

Page 38: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

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PREDICTOR OF SUCCESS (Ken Minkoff)

“The most significant predictor of treatment success for people with Co-occurring Disorders is the presence of an empathic, hopeful, continuous, treatment relationship in which integrated treatment and coordination of care can take place through multiple treatment episodes”.

Page 39: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Conclusions30 years of dual disorder research shows:

• Integrated Dual Disorders Treatment is effective

• The model works well for severe mental illness

• Certain interventions may be integrated to enhance substance use reduction and encourage addiction recovery

• IDDT can be individualized using stage-wise treatment, flexibility, comprehensive services, the assertive community treatment model, and a long-term perspective.

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Page 40: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

WestBridge Integrated Dual Disorders Treatment Model

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Page 41: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

• IDDT Program based on stage-based treatment model developed by Robert Drake, MD , PhD at Dartmouth PRC

• Multiple levels of care to allow for seamless transitions (residential-community)

• Private, non-profit organization with programs in Boston, New Hampshire, and Florida.

• Family-founded and family-centered, designed to rapidly implement evidence-based therapies

• No patients or clients, just participants & families

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Page 42: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Evidence-based practices @ WestBridge

• Evidence-based therapies:• Assertive community treatment • Supportive employment • Pharmacotherapy and medication monitoring• Cognitive-behavioral therapy• Behavioral family therapy/family education• Motivational interviewing• Contingency management/voucher systems• Regular urine toxicology screening• Twelve-step facilitation with mentor program• Mindfulness training 42

Page 43: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Advances in Integrated Dual Disorders Treatment:Opioid Dependence, Sleep Disorders, and Smoking

Cessation

FADAA/FCCM—Annual Conference 2013

Troy Pulas, MD

Medical Director, WestBridge Community Services, Brooksville, FL campus

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Page 44: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Objectives• Discuss a new integrated treatment model of opioid

dependence in a co-occurring disorder population

• Discuss the rationale for increased awareness, diagnosis, and treatment of sleep disorders in a co-occurring disorder population

• Discuss rationale for integration of smoking cessation treatment in a co-occurring disorder population

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Page 45: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Adapted by CESARFAX 1/30/12 from Centers for Disease Control and Prevention (CDC), National Center for Injury Prevention and Control (NCIPC), Drug Poisoning Deaths in the United States, 1980-2008, 2011.

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Page 46: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Prescription Opioids and Mental Illness

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Page 47: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Rate of Chronic Past Year Nonmedical Use of Prescription Drugs

Adapted by CESARFAX 7/16/12 from Jones, C.M., “Frequency of Prescription Pain Reliever Nonmedical Use: 2002-2003 and 2009-2010”, Archives of Internal Medicine, 2012.

While overall nonmedical use of prescription pain relievers did not increase from 2002-2003 to 2009-2010, Chronic nonmedical use—use on 200 or more days in the past year—increased significantly, from a rate of 2.2 to 3.8 per 1,000 people.

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Page 48: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Admissions reporting primary prescription opioid abuse, by age: 1998 and 2008

Source: SAMHSA Treatment Episode Data Set (TEDS), 1998 and 2008

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Page 49: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Buprenorphine for Prescription Opioid Dependence--POATS

Adapted by CESARFAX 12/5/11 from Weiss, R.D., et. al., “Adjunctive Counseling During Brief and Extended Buprenorphine-Naloxone Treatment for Prescription Opioid Dependence,” Archives of General Psychiatry, 2011.

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Page 50: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Buprenorphine Treatment Models• Outpatient-Based Opioid Treatment1

• Primary care/medical management2

• Collaborative care with nurse care managers3

• Adjunctive counseling (group/individual)4

• Private-pay physician or psychiatrist

• Practice-based Opioid Treatment (France)• Pharmacist-engaged5

• Clinic-Based Opioid Treatment (Australia)• Regular observed administration6

• Assertive Community Opioid Treatment Model

1Gunderson, Fiellin. 2008 CNS Drugs; 22 (2): 99-1112Barry D, et al. 2007. J Gen Int Med;22:242–245.3Alford D, et al. 2011. Arch Intern Med;171(5):425-431

4Weiss RD, et al. 2011. Arch of Gen Psych.

5Vignau, et al. 2001. JSAT.6Lintzeris, et al. 2004 Am J Add;13 Suppl 1:S29-41.

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Page 51: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Buprenorphine in primary care

Fiellin, et al. 2008. AJA, 17: 116–120.

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Page 52: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

3 6 9 12

Months after intake

Prop

orti

on r

etai

ned

in O

BO

T tr

eatm

ent

Age groupings18-2526-3031-4041-5051+

Age and Retention in B/N Collaborative Care OBOT Treatment

Schuman-Olivier, et al 2013

52

18-25 year olds

Page 53: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Why do emerging adults do so poorly in Buprenorphine treatment?• Could it be the same reasons that emerging adults

do poorly in other forms of substance abuse treatment?

• Not ready to stop (lack of consequences)

• Developmental challenges

• Difficulty giving up co-morbid substance abuse

• Poor self-help attendance

• Neurobiology

• Psychiatric co-morbidity

• Lack of integration of treatment

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Page 54: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Case:• 21 year old male with Obsessive Compulsive Disorder,

Major Depressive Disorder, Opioid Dependence• Living in Boston, attending college. Parents find out he has

been using intranasal heroin for 3 months after 9 months of daily prescription opioid use (~240mg/day of oxycodone).

• Drinking alcohol, using benzodiazepines, and regular marijuana use. History of overdose on alcohol and heroin.

• Contemplative about heroin, but does not want to stop alcohol or marijuana.

• Living with roommate who is also using heroin, dealing prescription opioids, and benzodiazepines, parents not aware of this.

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Page 55: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

WB risk calculator for buprenorphine/naloxone treatment for

people with co-occurring disorders

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Page 56: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Assertive Community Opioid Treatment Model, Integrated Services

• Risk Level 3 Services:• Daily care manager and/or substance abuse counselor meetings

=>Motivational Interviewing, engagement, supportive counseling, ACT, active treatment, education

• Twice weekly urine toxicology (M/Th, T/F) => Stage-wise treatment (work with relapse/continued use),

motivational interviewing , engagement• Weekly buprenorphine prescription, dispensed daily from lockbox by care

manager=> Multidisciplinary team, community outreach, flexible approach

• Weekly to twice monthly meetings with psychiatrist => Multidisciplinary team, psychiatric stabilization, education

• Alcohol or benzodiazepine detoxification when necessary=> Residential treatment, multidisciplinary team

• Sign treatment contract=> Non-confrontational, supportive

• Regular attendance to self-help meetings or group treatment=> Community integration, social support

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Page 57: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Assertive Community Opioid Treatment Model, Integrated Services

Risk Level 3: Encouraged (but not required) Services:

• Contingency contracting with daily money rationing or other forms of contingency management.

=>Structure, flexibility, case management

• Provide housing support when necessary

=>Case management, community outreach

• Disulfiram for alcohol dependence if indicated=>Multidisciplinary team, medication management

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Page 58: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

ACT Team: Diversion Prevention

• Lockboxes• Urine testing• Pill checks• Short prescriptions • In-office inductions• Observed administration

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Page 59: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Conclusions1. Opioid dependence is a dangerous problem, and

prescription opioid abuse is at crisis levels among emerging adults.

2. Dual diagnosis is very common among emerging adults with opioid dependence, and must be addressed in treatment models.

3. Buprenorphine/naloxone treatment improves retention and reduces opioid use; however, standard treatment models are poor at retaining emerging adults and those with co-occurring disorders.

4. An integrated dual disorder assertive community treatment team approach may offer promise for improving clinical outcomes, increasing safety and preventing diversion.

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Page 60: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Integrating Sleep Disorder Treatment

andDual Disorder

Treatment60

Page 61: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Brain Burden of Addiction and Sleep Disorders: $

SOURCE: Neuroinsights, Office of Nat’l Drug Policy, Nat’l Institute of Diabetes, Alz Assoc., Duke University, American Psych. Association, Harvard, Nat’l Sleep Found., American Stroke Assoc., Prevent Blindness America, CDC, Journal of Clinical Psych, Epilepsy Foundation, Cost of Brain Disorders Europe ( Lynch, Science Progress 2007)

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Page 62: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Outcomes of co-morbidity

• Dual Disorders and Sleep Disorders • Worse outcomes• Altered course of illness• Poor coping• Adverse drug reactions• Cognitive deficits

Horn and Sateia, J Dual Diagnosis, 2012 ; Hofstetter, et al BMC Psych 2005; Ritsner, et al Qual of Life Res 2004; Yang and Winkelman Schiz Res 2006; Krystal, Thakur, & Roth, Sleep 2008

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Page 63: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Sleep Stages• Non REM

• Stage 1: Fast Theta Waves, light sleep• Stage 2: Sleep Spindles, K complexes• Stage 3 & 4: Slow Delta Waves

• REM• Rapid Eye Movements, voluntary

muscles inactive

Penelope A. Bryant, John Trinder and Nigel CurtisNature Reviews Immunology 4, 457-467 (June 2004)

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Page 64: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Sleep and Addiction• Alcohol

• Insomnia: 36-75% while drinking or in withdrawal. Varies depending on many factors with sobriety.

• Time to fall asleep increases with drinking—tolerance to sedating effects (takes 5-9 months of abstinence to normalize).

• Total sleep time decreases with drinking (takes 1-2 years)• REM sleep % decreases during alcohol use (takes 3months-3 years )• REM occurs earlier in the night with drinking.• Sleep fragmentation, (takes 1-2 years)• Obstructive Sleep Apnea exacerbation

Brower et al Sleep Med Rev 2001. Brower Alcohol Res Health. 2001; 25(2): 110–125.Remmers Am Rev Resp Dis 1984. Stein et al J Subst Ab Treat 2004.

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Page 65: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Sleep and AddictionOpioids

• Insomnia: 84% • Central Sleep Apnea: 30-75% of people on methadone• Associated with Obstructive Sleep Apnea• Longterm consequence; chronic insomnia

Cocaine: • Increased wakefulness, suppressed REM sleep

Benzodiazepines:• Inhibit Stage 3&4 (slow wave sleep)

Marijuana• Reduced REM sleep, increased stage 4 sleep• Withdrawal: REM rebound, strange dreams

Nicotine• Association with Obstructive Sleep Apnea• Shorter sleep time, longer time to fall asleep, more leg movements

Brower et al Sleep Med Rev 2001; Jaehne A. Sleep Med 2012. Remmers Am Rev Resp Dis 1984; Stein et al J Subst Ab Treat 2004. Brower Alcohol Res Health. 2001; 25(2): 110–125

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Page 66: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Sleep disorders and Schizophrenia

• Schizophrenia presents with co-occurring substance use disorder 47-65% of the time!

Sleep disorders in schizophrenia:• Effects of antipsychotics on sleep are common (positive

and negative)• Obstructive Sleep Apnea: 48% • Periodic Limb Movement Disorder: 14-21%

(Ancoli-Israel, Biol Psych 1999; Lieberman, “CATIE” NEJM 2005; Bola et al Sleep 2008; Wang et al Chest 2005), Cohrs S, CNS Drugs 2008.

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Page 67: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Diagnosis and Intervention

Diagnosis:

• Sleep habits

• Sleep log

• Screening measures:

• Epworth Sleepiness scale

• Pittsburgh Quality Index

• Sleep study

Intervention:

• Sleep Hygiene

• Cognitive Behavioral Treatment

• Sleep Mentors

• Continuous Positive Airway Pressure (CPAP)

• Medications

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Page 68: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Sleep habits (staff assessment)• Note weight/ BMI

• 35

• Diet: timing of meals, content• No breakfast, chocolate bar at lunch, heavy dinner prior to bed

• Exercise/physical activity patterns• Walk 15 min/day

• Substance use and relationship with sleep (including smoking, coffee)• 2 cups of coffee at evening AA meeting; cigarettes prior to bed and

several times a night

• Day –time sleep• Wakes up at noon, 2 hour nap in the afternoon 68

Page 69: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Sleep Diary (self-report)

• What time did you go to bed last night? 10 pm (stayed awake due to hallucinations)

• What time you think you fell asleep? 4 am

• What time did you get up? 12 noon

• Did you wake up during your sleep time? no

• Overall, how tired did you feel yesterday, scale of 1 to 5 (Very tired = 5) ? 3

• How unusual or stressful was your day yesterday, scale of 1 to 5? (Very unusual or stressful = 5) 2

• How tired do you feel, scale of 1 to 5? (Very tired = 5) 569

Page 70: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Interventions

• Basic Sleep hygiene• Sleep at night• Bed use only for sleep, sex or sickness• Avoid caffeine • End psychosis engagement earlier

• Light therapy• CBT

• Progressive Muscle Relaxation• CBT for psychosis• Progressive desensitization of CPAP (claustrophobia)

• Sleep mentors/coaches• Personalized sleep plan 70

Page 71: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Medications• Evaluate underlying disorder• Antidepressants: Mirtazapine, Trazodone• Sedating antipsychotics if psychosis/bipolar disorder• Mood stabilizers (Carbamazepine in BZD/ ETOH

withdrawal)• Miscellaneous:

• Non-addicting medications• Hydroxyzine (Vistaril)• Melatonin• Clonidine• Gabapentin

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Page 72: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Conclusions: Sleep Improvement Tools

Sleep Log, Sleep Habits

Formal ScreeningSleep Hygiene

Personalized sleep plan

Light therapy

CBT

Sleep mentors

Sleep Study

CPAP 72

Page 73: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

SMOKING CESSATION FOR PEOPLE WITH CO-

OCCURRING DISORDERS

73

Page 74: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

OVERVIEW

• Prevalence and consequences of nicotine dependence in people with co-occurring disorders

• Brief review of evidence for treatment in people with severe mental illnesses

• Stage-based treatment approach with behavioral and pharmacologic interventions 74

Page 75: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

NicotineThe number one addictive substance

used by people who experience mental health and addictive disorders!

Smokers die 25 years earlier than general public!

75

Page 76: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Ferron, et al 2011 Psych Serv

76

Page 77: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Toxins in smoke cause heart disease, cancer, lung disease, diabetes

77

Page 78: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

PREMATURE MORTALITY BY HEART AND OTHER TOBACCO-RELATED ILLNESSES

05

101520253035

Percentage of deaths

Heart

Dise

ase

Cance

rCVDRes

pAcc

iden

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Flu/

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Suicid

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Data from Oklahoma 1996-2000; Colton et al, 2006 CDC

OTHER STATES LOOK THE SAME78

Page 79: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Combined cessation treatments improve outcomes in smokers with severe mental illnesses (15+studies)

• Abstinence after treatment in VA patients with co-occurring disorders

Review: Effect sizes in Schizophrenia 0.62-0.83 (Ferron 2009; Tsoi 2010)

6-12 wk group +/- NRT or buproprion in VA setting

Gershon-Grand, 2007 J Clin Psych79

Page 80: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

SYMPTOMS REMAIN STABLE DURING CESSATION TREATMENT

Scale for the Assessment of Negative Symptoms

Positive and Negative Symptom Scale

Evins, 2007 J Clin Psychopharm

80

Page 81: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

BRIEF MOTIVATIONAL INTERVENTIONS IMPROVE TREATMENT ENGAGEMENT

Higher percentage of people initiated cessation treatment after an electronic decision support-system

Brunette et al, 2011 Psychiatric Serv

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Page 82: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

MODELS OF INTEGRATED TREATMENT

• Medical management

• Brief meetings, support use of medications and coping (Williams et al, 2010 JSAT)

• Cognitive behavioral therapy (Individual or group)

• Teach self monitoring of urges and triggers

• Teach coping with urges and triggers

• Planning for quit day – other activities

• Group support (Cather, Gottlieb, Evins et al, 2010 SRNT)

• Contingency management

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Page 83: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Alternatives to Tobacco

• E-Cigarettes: • Does not address the habits associated with

smoking• Designed and sold by the tobacco companies to

reduce loss of income• Inhaling a substance which has unknown

consequences• If it is anything other than oxygen, the lungs do

not like it.

83

Page 84: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

MEDICATION FOR SMOKING CESSATION

• Nicotine Treatment• Gum• Patch• Lozenge

• Zyban/Wellbutrin• Chantix (varenicline)• Combination treatment

84

Page 85: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

WESTBRIDGE STAGE OF CHANGE APPROACH

• Precontemplation - Engagement – develop treatment relationship, assess nicotine use on treatment entry, monthly CO monitoring and brief intervention.

• Contemplation/Preparation - Persuasion – re-assess, provide education, motivational counseling - quarterly• Review pros and cons of tobacco use (financial, health, social)• Provide peer models for quitting to increase social norms• Increase self efficacy – teach skills, try medications• Practice replacement activities• Trials of NRT, periods of abstinence

85

Page 86: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

WESTBRIDGE STAGE OF CHANGE APPROACH• Action - Active treatment - Provide

medication and behavioral cessation treatment; support for long periods of time

• Relapse prevention – ongoing medication and relapse prevention training, peer support for abstinence

86

Page 87: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Conclusions

87

• Integrated Dual Disorder Treatment is an effective way to address co-occurring disorders.

• IDDT concepts can be used system-wide or in a targeted manner.

• IDDT can be modified to address opioid dependence, sleep disorders, and smoking cessation.

Page 88: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

QUESTIONS

88

Page 89: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

Contact Information:Feel free to contact us:

[email protected]

[email protected]

7300 Grove RoadBrooksville, FL 34613

Toll Free: 1-877-461-7711FL # 1-352-678-5553 89

Page 90: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

90

References:• Allness, D. J., & Knoedler, W. H. (1998). The PACT

model of community-based treatment for persons with severe and persistent mental illness: A manual for PACT start up.(2nd ed) Arlington, VA: NAMI

• Mueser, K. T., Noordsy, D. L., Drake, R. E., Fox, L (2003). Integrated treatment for dual disorders: A guide for effective practice. New York: Guilford Press.

• Multiple articles available from NH-Dartmouth Psychiatric Research Center: Contact for resources.

Page 91: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

91

References:• Miller, W. R., & Rolnick, S. (2002) Motivational

Interviewing (2nd ed.): Preparing People for Change. New York: Guilford Press.

• Prochaska, J. O., Norcross, J. C., & DiClemente, C. C. (1994) Changing for Good. New York: Avon Books. [Stages of Change]

• Woods, Mary & Armstrong, Katherine (2012) When The Door Opened. Manchester, NH: WestBridge 1361 Elm St. Manchester, NH 03101. www.westbridge.org

Page 92: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

92

References:• TIPS (SAMHSA)

• #35 Enhancing Motivation for Change in SA TX

• #42 SA TX for Persons With Co- Occurring Disorders

• http://store.samhsa.gov/product/TIP-35-Enhancing-Motivation-for-Change-in-Substance-Abuse-Treatment/SMA12-4212

• http://store.samhsa.gov/product/TIP-42-Substance-Abuse-Treatment-for-Persons-With-Co-Occurring-Disorders/SMA12-3992

Page 93: Advances in Integrated Dual Disorders Treatment FADAA/FCCM—Annual Conference 2013 Troy Pulas, MD Addiction Psychiatrist Judy Magnon, RN-BC BS,CAC 1

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References:• WEB SITES:

• WWW.COCE.samhsa.gov• WWW.Homeless.samhsa.gov• WWW.ATTCnetwork.org

• (The Addiction Technology Transfer Center Network)

• WWW.nimh.nih.gov