Advancing Cancer Surveillance in Less Resourced Settings Through Adaptation of SEER Analysis Tools

NAACCR 2018 Pittsburgh, PA June 14, 2018

Gonçalo Forjaz, Steve Scoppa, Dave Campbell, Sarah Quesnel-Crooks, Betsy Kohler, Glennis Andall-Brereton,

Damali Martin, Brenda Edwards

!2

Key metrics in cancer control.Mortality is a key

metric to measure progress against

cancer

NAACCR 2018 – June 14, 2018

Introduction

U.S. Mortality, NCHS, CDC

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Key metrics in cancer control.

NAACCR 2018 – June 14, 2018

Introduction

ComPrev CanSurv

Cancer surveillance

analytical tools

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NAACCR 2018 – June 14, 2018

Introduction

ComPrev CanSurv

SEER*Stat

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AGE YEAR SEX ICD-1056 2014 1 C34157 2014 1 C34158 2014 1 C34359 2014 1 C34960 2014 1 C34261 2014 1 C34062 2014 1 C341

AGE YEAR SEX ICD-1056 2014 1 C34157 2014 1 C34158 2014 1 C34359 2014 1 C34960 2014 1 C34261 2014 1 C34062 2014 1 C341

NAACCR 2018 – June 14, 2018

Introduction

One record per death

4-digit level COD

SEER*Stat

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NAACCR 2018 – June 14, 2018

Introduction

SEER*Prep SEER*Stat

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NAACCR 2018 – June 14, 2018

✓Added support for processing grouped data

✓Added a new Cause of Death recode based on 3-digit ICD-9 and ICD-10 codes

✓US cancer mortality data for 1979-2015 was compared to existing SEER Cause of Death Recode to validate the new classification

Methods

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AGE YEAR SEX ICD-10 DEATHS25‒29 2014 1 C34 4330‒34 2014 1 C34 5835‒39 2014 1 C34 6040‒44 2014 1 C34 6545‒49 2014 1 C34 7150‒54 2014 1 C34 8055‒59 2014 1 C34 95

AGE YEAR SEX ICD-10 DEATHS25‒29 2014 1 C34 4330‒34 2014 1 C34 5835‒39 2014 1 C34 6040‒44 2014 1 C34 6545‒49 2014 1 C34 7150‒54 2014 1 C34 8055‒59 2014 1 C34 95

NAACCR 2018 – June 14, 2018

Grouped data

3-digit level COD

SEER*Prep

Methods

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NAACCR 2018 – June 14, 2018

Methods

Lip, Oral Cavity and PharynxLip 140 C00 20010Tongue 141 C01-C02 20020Salivary Gland 142 C07-C08 20030Floor of Mouth 144 C04 20040Gum and Other Mouth 143, 145 C03, C05-C06 20050Nasopharynx 147 C11 20060Tonsil 146.0‒ 146.2 C09 20070Oropharynx 146.3‒146.9 C10 20080Hypopharynx 148 C12-C13 20090Other Oral Cavity and Pharynx 149 C14 20100

SEER Cause of Death Recode ‒ 4-digit ‒

Cancer Causes of Death

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NAACCR 2018 – June 14, 2018

Lip, Oral Cavity and PharynxLip 140 C00 20010Tongue 141 C01-C02 20020Salivary Gland 142 C07-C08 20030Floor of Mouth 144 C04 20040Gum and Other Mouth 143, 145 C03, C05-C06 20050Nasopharynx 147 C11 20060Tonsil 146.0‒ 146.2 C09 20070Oropharynx 146.3‒146.9 C10 20080Hypopharynx 148 C12-C13 20090Other Oral Cavity and Pharynx 149 C14 20100

Cancer Causes of Death

ICD-9 (1979-1998)

MethodsSEER Cause of Death Recode

‒ 4-digit ‒

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NAACCR 2018 – June 14, 2018

Lip, Oral Cavity and PharynxLip 140 C00 20010Tongue 141 C01-C02 20020Salivary Gland 142 C07-C08 20030Floor of Mouth 144 C04 20040Gum and Other Mouth 143, 145 C03, C05-C06 20050Nasopharynx 147 C11 20060Tonsil 146.0‒ 146.2 C09 20070Oropharynx 146.3‒146.9 C10 20080Hypopharynx 148 C12-C13 20090Other Oral Cavity and Pharynx 149 C14 20100

Cancer Causes of Death

ICD-9 (1979-1998)

ICD-10 (1999+)

MethodsSEER Cause of Death Recode

‒ 4-digit ‒

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NAACCR 2018 – June 14, 2018

Lip, Oral Cavity and PharynxLip 140 C00 20010Tongue 141 C01-C02 20020Salivary Gland 142 C07-C08 20030Floor of Mouth 144 C04 20040Gum and Other Mouth 143, 145 C03, C05-C06 20050Nasopharynx 147 C11 20060Tonsil 146.0‒ 146.2 C09 20070Oropharynx 146.3‒146.9 C10 20080Hypopharynx 148 C12-C13 20090Other Oral Cavity and Pharynx 149 C14 20100

Cancer Causes of Death

ICD-9 (1979-1998)

ICD-10 (1999+) Recode

MethodsSEER Cause of Death Recode

‒ 4-digit ‒

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NAACCR 2018 – June 14, 2018

Methods

IARC CI5 Grouping

CDC NCHS Translator

NCI SEER COD Recode

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NAACCR 2018 – June 14, 2018

Results

Lip, Oral Cavity and PharynxLip 140 C00 20010Tongue 141 C01-C02 20020Salivary Gland 142 C07-C08 20030Floor of Mouth 144 C04 20040Gum and Other Mouth 143, 145 C03, C05-C06 20050Nasopharynx 147 C11 20060Tonsil and Oropharynx 146 C09-C10 20070Hypopharynx 148 C12-C13 20090Other Oral Cavity and Pharynx 149 C14 20100

Cancer Causes of Death

ICD-9 (1979-1998)

ICD-10 (1999+) Recode

New SEER Cause of Death Recode ‒ 3-digit ‒

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NAACCR 2018 – June 14, 2018

Results

Digestive SystemOesophagus 150 C15 21010Stomach 151 C16 21020Small Intestine 152 C17 21030Colon and Rectum

Colon excluding Rectum 153, 159.0 C18, C26.0 21040Rectum and Rectosigmoid Junction 154.0‒154.1 C19-C20 21050

Anus, Anal Canal and Anorectum 154.2‒ 154.3, 154.8 C21 21060Liver and Intrahepatic Bile Duct

Liver 155.0, 155.2 C22.0, C22.2-C22.4, C22.7, C22.9 21071Intrahepatic Bile Duct 155.1 C22.1 21072

Gallbladder 156.0 C23 21080Other Biliary 156.1-156.2, 156.8-156.9 C24 21090Pancreas 157 C25 21100Retroperitoneum 158.0 C48.0 21110Peritoneum, Omentum and Mesentery 158.8-158.9 C48.1-C48.2 21120Other Digestive Organs 159.8-159.9 C26.8-C26.9, C48.8 21130

Cancer Causes of Death

ICD-9 (1979-1998)

ICD-10 (1999+) Recode

New SEER Cause of Death Recode ‒ 3-digit ‒

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NAACCR 2018 – June 14, 2018

Results

Digestive SystemOesophagus 150 C15 21010Stomach 151 C16 21020Small Intestine 152 C17 21030Large Bowel

Colon 153 C18 21040Rectum and Anus 154 C19-C21 21050

Liver and Intrahepatic Bile Duct 155 C22 21070Gallbladder and other Biliary 156 C23-C24 21080Pancreas 157 C25 21100Retroperitoneum, Peritoneum,Omentum and Mesentery 158 C48 21110

Cancer Causes of Death

ICD-9 (1979-1998)

ICD-10 (1999+) Recode

New SEER Cause of Death Recode ‒ 3-digit ‒

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NAACCR 2018 – June 14, 2018

Results

LymphomaHodgkin Lymphoma 201 C81 33010Non-Hodgkin Lymphoma 200, 202.0-202.2, 202.8-202.9 C82–86, C96.3 33040Leukemia

Lymphocytic LeukemiaAcute Lymphocytic Leukemia 204.0 C91.0 35011Chronic Lymphocytic Leukemia 204.1 C91.1 35012Other Lymphocytic Leukemia 202.4, 204.2, 204.8-204.9 C91.2-C91.4, C91.6-C91.9 35013

Myeloid and Monocytic Leukemia

Acute myeloid 205.0, 207.0, 207.2 C92.0, C92.4-C92.6, C92.8, C94.0, C94.2 35021

Acute Monocytic Leukemia 206.0 C93.0 35031Chronic Myeloid Leukemia 205.1 C92.1 35022

Other Myeloid/Monocytic Leukemia 205.2-205.3, 205.8-205.9, 206.1-206.2, 206.8-206.9

C92.2-C92.3, C92.7, C92.9, C93.1-C93.3, C93.7, C93.9 35023

Other LeukemiaOther Acute Leukemia 208.0 C94.4, C94.5, C95.0 35041

Aleukemic, subleukemic and NOS 203.1, 207.1, 207.8, 208.1-208.2, 208.8-208.9

C90.1, C91.5, C94.1, C94.3, C94.7, C95.1, C95.2, C95.7, C95.9 35043

Cancer Causes of Death

ICD-9 (1979-1998)

ICD-10 (1999+) Recode

New SEER Cause of Death Recode ‒ 3-digit ‒

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NAACCR 2018 – June 14, 2018

Results

Cancer Causes of Death

ICD-9 (1979-1998)

ICD-10 (1999+) Recode

LymphomaHodgkin Lymphoma 201 C81 33010Non-Hodgkin Lymphoma 200, 202 C82-C86, C96 33040Leukemia

Lymphoid Leukemia 204 C91 35011Myeloid Leukemia 205-207 C92-C94 35021Leukemia Unspecified 208 C95 35041

New SEER Cause of Death Recode ‒ 3-digit ‒

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NAACCR 2018 – June 14, 2018

Results

100% Correspondence

22 out of 26 non-cancer COD

35 out of 47 cancer COD

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NAACCR 2018 – June 14, 2018

ResultsAll Cancers

SEER COD Recode

‒ ICD-9 ‒ 140-208, 238.6 ‒ ICD-10 ‒

C00-C97

19,371,707 deaths

New SEER COD Recode

19,370,893 deaths

‒ ICD-9 ‒ 140-208

‒ ICD-10 ‒

C00-C97

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NAACCR 2018 – June 14, 2018

ResultsAll Cancers

3-digit

4-digit-0.7 (-0.8 to

-0.6)

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NAACCR 2018 – June 14, 2018

ResultsColorectal

SEER COD Recode

‒ ICD-9 ‒ 153-154, 159.0 ‒ ICD-10 ‒

C18-C21, C26.0

2,043,733 deaths

New SEER COD Recode

2,033,571 deaths

‒ ICD-9 ‒ 153-154

‒ ICD-10 ‒

C18-21

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NAACCR 2018 – June 14, 2018

ResultsColorectal

-2.0 (-2.1 to -1.8)

-1.8 (-2.0 to -1.6)

3-digit

4-digit

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ResultsLung

3-digit

4-digit

-0.5 (-0.6 to -0.4)

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ResultsNHL

3-digit

4-digit

-0.2 (-0.4 to -0.1)

-0.3 (-0.5 to -0.1)

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NAACCR 2018 – June 14, 2018

ResultsLeukemia

3-digit

4-digit

-0.8 (-1.0 to -0.6)

-0.7 (-0.9 to -0.5)

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NAACCR 2018 – June 14, 2018

✓ Improved features facilitate use of SEER analysis tools

✓The 3-digit classification matched almost all the ICD-9/ICD-10 groupings.

✓Confidentially restrictions are not an obstacle to data analysis

✓ Less-resourced settings are able to use limited data

Conclusion

NAACCR 2018 Pittsburgh, PA June 14, 2018

Thank you!