advancing neuromodulation research · originally developed at the university of michigan,...
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Advancing neuromodulation research
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Originally developed at the University of Michigan, NeuroNexus’ suite of commercialized technologies has, for over a decade, led to hundreds of publications from research labs all around the world. Our products include conventional and high-density leads, recording and stimulation systems, and software for data analytics.
Our products have been used in a wide variety of animal models from fruit fly to rodent to non-human primates. NeuroNexus is currently working to make our state-of-the-art technologies and systems available for human clinical research.
NeuroNexus is the global leader in neuroscience research. Now expanding into clinical research.
Next page, clockwise from top left: Matrix Array™, Vector Array™,
SmartBox™, Quad-fiber Optoelectrode. See the NeuroNexus Research
Product Catalog at neuronexus.com for more information.
Currently not available for sale
NeuroNexus is an official NIH BRAIN Initiative® partner.
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NeuroNexus is at the intersection of neuroscience, technology, and clinical drivers.
Science drivers: NeuroNexus powers leading-edge neuroscience research around the world
Technology drivers: NeuroNexus continually
innovates neural interfaces to meet the needs of
both scientific and clinical research
Clinical drivers: NeuroNexus is uniquely
positioned to translate new technologies into innovative neuromodulation systems
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• High resolution thin-film technologies utilizing silicon and polymer materials
• Draw from our design tools and libraries for advanced thin-film neural interfaces
• Translation of leading-edge concepts into commercial solutions
• Computational modeling and analysis of neural interface devices and systems
• Rapid prototyping
• Resources and expertise for testing and validation
• Collaboration and networking with leaders in the clinical and neuroscience fields
Core Technologies and Competencies
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NeuroNexus offers a custom lead design service that provides unique access to a virtually unlimited design space. Almost any feature of a lead can be tailored to suit your application - and all it takes to get started is a sketch.
Each custom lead includes:
• Consultation with our engineering team to validate feasibility of your proposed design
• Translation of your design into a CAD layout
• Formal design review with our technical team
• State-of-the-art microfabrication of your design
• Packaging and testing of the fabricated devices
• Ability to imprint text (such as your name) on the lead
Custom Design
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NeuroNexus offers both conventional and high density lead technologies.
• History of clinical use• Robust mechanical properties• Body compliant
• High channel count, high density• Ultra flexible• Can be integrated into form factors of
conventional systems• Customizable shape and electrode coverage
Conventional Lead Technologies
High Density Lead Technologies
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Images not to scale.
SPECIFICATIONS
LEADS FOR BRAIN/SPINAL CORD SURFACE
Conventional HD
Substrate
Electrode Material
Silicone/Polyurethane, millimeter thickness
Platinum Iridium
Electrode Coverage Millimeter spatial resolution
Maximum current mA
Regulatory Status FDA Approved
Number of Channels 8, 12
Thin-film, micron thickness
Platinum
Micron spatial resolution
µA - mA
In Process
16, 32, 64+, customizable
Impedance kΩ range kΩ - MΩ range
Flexibility Body compliant Ultra-flexible
Usage Stimulation Stimulation, Sensing (ECoG, µECoG, CAP)
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Images not to scale.
LEADS FOR DEEP BRAIN MAPPING OR STIMULATION
SPECIFICATIONS Conventional HD - Stimulation HD - Mapping
Substrate
Electrode Material
Silicone, millimeter thickness
Platinum Iridium
Electrode Coverage Millimeter spatial resolution
Maximum current mA
Regulatory Status FDA Approved
Number of Channels 8, 12
Thin-film with silicone/polyurethane backing
Platinum
Micron spatial resolution
µA - mA
In Process
24, 48, customizable
Impedance kΩ range kΩ - MΩ range
Usage Stimulation Stimulation, Sensing (AP, LFP)
Thin-film combined with conventional wire
Platinum
Micron spatial resolution
µA - mA
In Process
16, 32, customizable
kΩ - MΩ range
Stimulation, Sensing (AP, LFP)
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SPECIFICATIONS
INTRACORTICAL LEADS
HD
Substrate Material
Electrode Material
Silicon
Iridium
Electrode Resolution < 50 µm, customizable
Usage Stimulation (electrical and optical), Sensing (Action potential, Field potential)
Regulatory Status In Process
Number of Channels 64, 128
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Images not to scale.
NERVE LEADS
SPECIFICATIONS Conventional HD
Substrate
Electrode Material
Silicone/Polyurethane, millimeter thickness
Platinum Iridium
Electrode Coverage Millimeter spatial resolution
Maximum current mA
Regulatory Status FDA Approved
Number of Channels 2-3
Polyimide, micron thickness
Platinum
Micron spatial resolution
µA - mA
In Process
12, 24, customizable
Impedance kΩ range kΩ - MΩ range
Flexibility Flexible Ultra-flexible
Usage Sensing Sensing, Stimulation
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Clinical SmartBox™ Platform - Recording Module*
• State-of-the-art technology, affordable pricing
• Record up to 256 channels simultaneously
• Up to 30 kHz sampling rate per channel
• 16-bit ADC resolution, 15 µV smallest detectable signal
• Electrode diagnostic (impedance check) and site conditioning mode
• Wide variety of signals supported: EEG, EMG, action potential, field potential, pulsation
• Portable with optional battery pack - take your recording system and laptop with you, and record from anywhere
• DAC out for audio monitoring
• Arrives ready to go, with minimal setup required; Laptop included
The NeuroNexus SmartBox™ is a portable control and data acquisition system.
Above: SmartBox™
Inset: GUI
*Available in 2016
LEARN MOREVisit our YouTube channel to learn more about our products: youtube.com/TheNeuroNexus
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Images not to scale.
Clinical SmartBox™ Platform - Stimulation Module*
• Can be integrated to perform simultaneous recording and stimulation
• 25 stimulation channels with independent constant current sources
• Stimulate up to 15 mA
• Highly flexible programming to support advanced stimulation protocol
• Wirelessly controlled (up to 1 meter range)
• Can be battery powered (2 weeks of operation with typical usage)
• Arbitrary waveform generation
• Implantable, wearable, and desktop versions available
*Available in 2016
Desktop Stimulation Module
WearableStimulation Module
Implantable Stimulation Module
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Surgical Consultation & Neural AnalyticsAdapting to new technology and techniques can be difficult. NeuroNexus staff engineers and scientists have decades of combined experience, and we can help you reduce your ramp-up time so you can focus on your research.
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655 Fairfield Ct., Ste. 100 / Ann Arbor, MI 48108, USA
neuronexus.com / +1.734.913.8858 (Phone) / +1.734.786.0069 (Fax)
N O T E S
Currently not available for sale
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