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BACKGROUND AND EDUCATION

AFFIDAVIT

I

I am Bemard C. Korbitz, M.D., currently Chief of the Chemotherapy Section, Department of Oncology at the Radiologic Center, Inc., Neb-raska Methodist Hospital, Omaha, Nebraska 68114. (Please see the attached curriculum vitae for a background breakdown of my undergraduate, graduate and medical school training as well as fellowships and residencies taken). l have been involved with various aspects of cancer research .and cancer therapy since approximamly 1954 when I first began working in the Divi­sion of Clinical Oncology at the University of Wisconsin Medical Center as a premedical student.

II

INTRODUCTORY STATEMENT mi CANCER

Cancer is an inclusive term used to refer to malignant tumors of glands, mucosa and integument comprising the so-called carcinomas and tumors of connective tissue such as cartilage, bones, lymph nodes, etc., known as sarcomas. Cancer in its broadest sense also includes malignant transformations of cells in the bone marrow such as acute and chronic leukemias, as well as t1U1ltiple myeloma (plasma cell myeloma). At the present time there are t1U1ltiple theories of causation of the malignant transformation in cells. It is known that many chemical substances are capable of inducing a malignant transformation such as various coal tar derivatives, aniline substances in the environment such as cigarette smoke, etc. It is also known that under certain circumstances ultraviolet light, ionizing radiation and in sore instances certain viruses can evoke a malignant change. All of these various carcinogens produce their effects on a cell by inducing a mutation or a disruption in the nucleus of the cell in the genetic material or chromosomes. Basically this "insult" effects the double helix of the DNA found in the nucleus.

Proponents of a current quack remedy known as Laetrile hold to the so-called trophoblastic theory of carcinogenesis. This outmoded theory first propounded by Beard has been discarded by knowledgeable sci­entists for many years and has no place in modern thinking.

Cancers of almost any site of origin eventually make their pre­sence in the human known by the fact that _the tumors tend to invade normal tissues and spread (metastasize). The patients then generally develop symptoms such as weakness, l9ss of weight, bleeding from a body orifice, interference with swallowing or digestion, or the presence of anemia, lump in the breast or elsewhere in the body, chronic cough and other such symptoms. When the tumor has produced an alteration in function of the

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various organs of the body appropriate screening tests may then indi­cate the presense of cancer secondarily by a defect in functioning of the involved organ. As an example, cancer involving the liver fre­quently results in abnormal liver function tests. Cancer in the lung makes its presence known many times by an abnormal:density seen on a chest X-ray. Cancer of the prostate frequently spreads to bones and may be detected by blood tests which are used to screen for anemia, elevations of acid and alkaline phosphatase enzymes and X-rays which show characteristic changes in the involved bones. Many cancers which effect the bone marrow will produce anemia, changes in the white blood count and changes in the platelet count.

A test which is frequently propounded by proponents of Laetrile is the so-called B.A.T. or the Beard Anthrone test. This test suppos­edly measures the presence of chorionic gonadotrophin in the urine. How­ever, it has been discarded by many of the staunchest Laetrile supporters as being somewhat difficult to interpret. To my knowledge, some physi­cians in the Philippines still attempt to relate a patient's cancer acti­vity to the degree of reaction they obtain in a patient's urine using the so-called Beard Anthrone test. This test has been generally discarded as being worthless as to determining the presence or absence of cancer or the activity of cancer.

CURRENT THERAPY OF CANCER

II B

- At the present time it is well recognized that surgery is still ~--_ the main line of defense against most cancers and is still the best means

_ of achieving cures. Radiation therapy has an increasingly important role as not only a useful agent for palliation of advanced cancer,but also is a form of curative therapy in many cancers such as skin cancers and cancer of the cervix. It is also beginning to play an increasingly important role as curative therapy in carcinoma of the prostate. Chemotherapy today is playing an increasingly important role in therapy of advanced. cancers including leukemia and Hodgkins Disease. There are currently over thirty commercially available drugs which are very effective against m.u~y forms of carcinoma,sarcomas, leukemias and multiple myeloma. When ad­ministered by physicians trained in the field of medical oncology and hematology these agents produce long-term remissions and very effective palliation of patients with cancer.

III

THEORY AND DISCUSSION OF IAETRILE

Laetrile or Amygdalin is a cyanotrile which is derived £ran apricot pits. This compound can be artifically synthesized, but is commercially made by an alcohol ether extraction from ground apricot pits.

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The substance has been thoroughly evaluated in many animal tumor screening systems in this country. This consists of the same type pre­clinical cancer screening which is used to evaluate all new potential .anti-cancer agents in this country. To date there has been no bona fide or substantiated evidence that Laetrile has any significant anti­tumor effect in any of the rodent animal systems evaluated. In addition, Laetrile has shown no effect in humans when evaluated by the California Medical Association in its very well publicized studies of Laetrile in the early 1950s. Critics of the California Medical Association study have claimed that inadequate doses of Laetrile were used. I have reviewed reports by Dr. Navarro in the Philippine Medical Journal who purported to have produced good results in cancer patients using larger doses. In reviewing his studies there is no objective evidence to support these claims that Laetrile is effective in any dose range against cancer.

The proponents of Laetrile claim that because of the presence of Beta glucosidase in cancer cells th:is substance (Laetrile) is a specific remedy for the cancer cell and is harmless to normal cells. They theorize that normal cells lack the "splitting enzyme" or glucosidase and that cancer cells have an excess of this enzyme. They therefore theorize that cyanide is released only in the cancer cells and therefore results in their death, while not harming normal tissues. This theory is totally wrong since many normal tissues of the body have extrezcely high concentrations of glucosidase, (such as: liver, spleen and white blood cells). On the other hand there are some tumor cells whichare virtually devoid of Beta-glu­cosidase activity. The theory is therefore on extremely shaky ground and the results in animal screening systems bear out the fact that Laetril~ is without significant anti-tumor activity.

IV

PERSONAL KNOWLEDGE OF PATIENTS WHO HAVE RECEIVED IAETRILE

I am currently involved in the therapy of at least one patient who is still on radiation therapy for her metastatic carcinoma of the breast. This patient claims to have been "cured" of her breast cancer by receiving Laetrile therapy in Mexico. She was told that when she finished Laetrile therapy she would still probably need some radiation treatment for pain control, but that her cancer was under control. At the present time she is still having significant pain requiring analgesics. The patient also has profound anemia due to cancer involvement of her bone marrow and X-rays reveal wide-spread metastatic disease causing collapse and frac­tures of portions of her spine. The patient is receiving radiotherapy and at the present time hormone therapy for her cancer. It is obvious that she has received absolutely no benefit from Laetrile.· However, the patient still has steadfast belief that she was cured by Laetrile.

Another patient I have recently treated is a forty-five year old truck driver from Wisconsin who has wide-spread metastatic lesions in both lungs from carcinoma of the rectum. The patient's disease was

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beginning to progress on 5 Fu. therapy and I recommended placing him on combination chemotherapy with Mitomycin C. The patient's family convinced him to go to Mexico for Laetrile therapy. I obtained chest X-rays prior to his leaving and again when he had completed his course of Laetrile therapy in Mexico. At the completion of his Laetrile therapy his chest X-ray showed definite progression of all of the meta­stases in the lungs and he had lost weight and was feeling weaker. He admitted that he did not achieve any significant benefit from the Lae­trile therapy, although he did feel that he possibly felt somewhat better for one week in Mexico while being given a very nourishing diet and many vitamins. Actually at the time he returned from Mexico he had peripheral lymph nodes which had also increased in size apprec­iably during the period of time that he had not been receiving his standard chemotherapy.

SUMMA.RY AND CONCLUSIONS

I have been involved in various aspects of cancer research and. therapy for approximately twenty-three years. My years as a practicing physician have been devoted essentially entirely to the field of oncology, hematology and internal medicine. I have evaluated all the available Laetrile data for cancer patients. There is no objective evidence of any sort from pre-clinical or sketchy clinical reports to indicate that Laetrile has any benefit in the treatment of cancer patients. I would feel that there are many potential dangers in the use of Laetrile in cancer patients;.

--Patients who use this worthless remedy are obviously losing valuable time which could be used to treat their cancer with proven effective remedies such as surgery, radi~tion therapy and standard chemotherapy. Patients may have their cancer progress to untreatable stages by their delay in seeking treatment by competent qualified individuals using orthodox scientific methods of treatment.

--Laetrile is a somewhat crude preparation of Amygdalin. and I am fearful that the quality control involved in its production by the Mexican manufacturers leaves a great deal to be desired •. I am particularly fearful that patients who receive the intravenous medication may be in danger of receiving intravenous preparations which may be contaminated with such things as hepatitis virus, pathogenic bacteria, pathogenic fungi and other organisms.

It is TirJ firm belief that since Laetrile has not shown any signi­ficant anti-tumor effect in any of the animal screening systems used and since there is no objective evidence to indicate that it has any efficacy in humans, I would feel that this medication should not be allowed to be used in the United States for the treatment of humans.

Bernard C. Korbitz,i-M'.D.

STATE OF NEBRASKA) ) ss.

COUNTY OF DOUGIAS )

Before me this 16th day of March, 1977 comes Bernard C. Korbitz,

and deposes and states on oath that the above said Affidavit is true

as he verily believes.

SUBSCRIBED AND stiORi.~ to before me this 16th day of March, 1977 at Omaha, Nebraska. .o ,r-/ /

~& (! YivtfM; NOTARY

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ADDENDUM:

Current Position:

Chief of Chemotherapy Section Department of Oncology Radiologic Center, Inc. Nebraska Methodist Hospital 8303 Dodge Street Omaha, Nebraska 68114 Phone: (402) 397-1770

Hospital:

Nebraska Methodist Hospital Children's Memorial Hospital

Comnittees:

Nebraska Methodist Hospital Cancer Conmittee Ad Hoc Long Range Planning Coumittee

Licensed to practice medicine in Nebraska

No. 13364

Member of Nebraska Medical Association, Greater Omaha Medical Society

Bibliography:

Author or co-author of approximately 40 articles relating to cancer, hematology and internal medicine.

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~= :ess: Residence

Office

:hdate:

:hplace:

'.zenship:

ltal Status:

ldren:

:ation:

:ees:

~rnship:

.dency and Fellowship Training:

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CURRICtn.UM VITAE

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February 18, 1935 OMA# /Ve Gi'II/

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Lewistown, Montana

U.S. citizen by birth

Married. Wife's name, Constance

Two sons Paul B. Korbitz, born December 27, 1962 Guy K. Korbitz, born January 21, 1967

Primary and secondary schools Medford, Wisconsin

B.S. (Medical Science)_ 21 June 1957 University of Wisconsin Madison, Wisconsin

M.D; 6 June 1960 University of Wisconsin Madison, Wisconsin

M.S. (Oncology) 4 June 1962 University of Wisconsin Madison, Wisconsin

Law student in correspondence studies LaSalle University, Chicago, Illinois July 1969 to October 1972. Received Diploma of Graduation in American Law and Procedure July 17, 1972.

LL. B. 27 October 1972, LaSalle· Unive·rsity

1960-61 Denver General Hospital Denver, Colorado (General rotating)

1961-62 Postdoctoral Fellowship in Oncology University of Wisconsin

-:·· --~-. .... - -·- - .. - --·-· - ·- ····--· -··- .. ·-··--·----_____ ... .- .. .-.-..

idency and Fellowship Training:

itary Experience:

ulty Appointments:

!r Medical Experience:

l

1964-66

1966-67

t .. , 1962-64

1961-62

Internal Medicine Residency University of Colorado Medical Center Denver, Colorado

Hematology Fellowship Presbyterian Medical Center

. Denver, Colorado

U.S. Air Force Medical Service Served as Chief, Outpatient Service, 3510th USAF Hospital, Randolph AFB, Texas. Discharged with rank of Captain.

Post-Doctoral Fellow, Department of Clinical Oncology, University of Wisconsin, Madison, Wisconsin

1964-66 Resident & Assistan~, Department of Medicine, University of Colorado Medical Center Denver, Colorado

1967-70 Joint appointment as Assistant Professor of Clinical Oncology and Medicine, University of Wisconsin Medical Center

1970-71 Assistant Clinical Professor of Medicine and Pathology University of Wisconsin Medical Center

197.1-73 Assistant Clinical Professor of Medicine, University of Colorado Medical Center, Denver, Colorado

l '/?i:, 1973~ Clinical Associate Professor of

Radiology (Therapeutic. Radiology), University of Wisconsin Medical Center

1954-1960 Worked part-time as res·earch assistant in Division of Clinical Oncology, University of Wisconsin, Madison, Wisconsin. This employment included three summer research appointments.

1970-1971 Private practice of Hematology, Oncology & Internal.Medicine, Madison, Wisconsin

1971-1973 Established Clinical Oncology Training Program at Presbyterian Medical Center, Denver,'Colorado. Also served as Director of Department of Medicine--responsible

for educational program for medical residents, interns, medical students, and externs.

•,

!r Medical Experience: :ont 'd)

t:ds and Honors:

:essional Societies:

•· .......... ---•·· - ·---------------------------------------•--J ............. .

I 'l?L, . 1973· ~~ Private practice of Medical

Oncology, Hematology, Internal Medicine, Medico-Legal Consultant, Madison, Wisconsin

1953-1957 William S. Kies Scholar University of Wisconsin

1954 Phi Eta Sigma University of Wisconsin

1955 Sophomore High Honors University of Wisconsin

1956 Phi Beta Kappa University of Wisconsin

1957 Phi Kappa Phi University of Wisconsin

1959 Alpha Omega Alpha University of Wisconsin

1961-1962 U.S. Public Health Post-Doctorai Fellowship Award .University of Wisconsin

1966-1967 Maytag Cancer Research Fellowship Award Presbyterian Medical Center Denver, Colorado

May, 1975 Honored by the American Heritage Research Association by being permanently inscribed in its Library of Human Resources as part of the Bicentennial Observance of the United States of America

Madison Academy of Internal Medicine American College of Physicians Phi Chi Medical Fraternity· Dane County Medical Society Wisconsin State Medical Society American Medical Association American Society of Internal Medicine Wisconsin Society of Internal Medicine American Geriatrics Society American Society of Clinical Oncology The Royal Society of Health American College of Legal Medicine Associate Member Denver Medical Society Wisconsin Medical Alumni Association Colorado Medical Alumni Association .American Association of Medico-Leo:tl Con~11l f-:tnt-!'I

4

nsure:

lal ty Boards:

ital Staff: Previous f Appointments in ;on, Wisconsin, and ar, Colorado

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1958 Wisconsin Basic Science Certificate (by exam) #10556 4-19-58

1961 Diplomate of National Board of Medical Examiners #62549 7-1-61

1961 Licensed to practice Medicine in Wisconsin (by exam) #14115 8-21-61

1964 Colorado Basic Science Certificate (by exam) #5915 5-8-64

1964 Licensed to practice Medicine in Colorado #14872 7-14-64

BNDD number: AK-5543992

Certified as a diplomate of the .American Board of Internal Medicine, April 27, 1967. Certificate #25715

Recertified by American-Board of Internal Medicine, October 26, 1974. Certificate #25715

Certified by American Board of I~ternal Medicine in Medical Oncology. October 16, 1973.

Elected to Fellowship in the American College of Physicians, November 9, 1968.

Elected to Fellowship in the Royal Society of Health, August 10, 1971.

St. Marys Hospital Medical Center Associate Staff 1970-71 Member of Infectious Disease, Radioisotope and Cancer Cormnittee (Co-Chairman Cancer Committee)

Madison General Hospital Courtesy Staff 1970-71

Methodist Hospital Courtesy Staff 1970-71

University Hospitals -- Madison Courtesy Staff 1970-71

Director, Department of Internal Medicine Presbyterian Medical Center Denver, Colorado 80218 Courtesy Staff 1971-72 Associate Staff September 1, 1972 -- July 7, 1973

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· f'R fv 1() vs il9JIIC Hospital Staff:

/N M/.ld1!,~1V_, l.v15c,_

ellaneous Appointments and ,mmittees:

Methodist Hospital Courtesy Staff

Madison General Hospital Courtesy Staff Member of Tumor Board

St. Marys Hospital Member Active Staff Member of Tumor Board Member of Radioisotope Committee

University Hospitals, Madison, Wisconsin Courtesy Staff

Member of Wisconsin State Medical Society Conunittee on Peer Review

Member of Mt. Olive Lutheran Church, Senior Education Elder and Member of Church Council, 1974-75

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MISCELLANEOUS ACTIVITIES IN DENVER, COLOR.ADO

1971 -- 1973

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1. Director of Medical Oncology Fellowship Program, Presbyterian Medical Center.

2. Chairman, Cancer Control Committee, Presbyterian Medical Center.

3. Member of following Committees at Presbyterian Medical Center.

a) General Education Connnittee b) Internal Medicine Education Committee c) Infectious Disease Control Committee d) Medical Advisory Board e) ~edical Records Committee (1971-1972)

4. Assistant Cubmaster, Pack 736, Prospect Valley School, Wheatridge, Colorado.

5. Member of Advisor.y Committee for Plant Expansion Environmental Assessment, Metropolitan Denver Sewage Disposal, District No. 1.

• I ~age 7

• BIBLIOGRAPHY

1. Korbitz, B.C.: Pyridoxine-Magnesium Interrelationship and Tryptophan Metabolism in the White Rat, M.S. Thesis, University of Wisconsin, 1962.

2. Korbitz, B.C., Price, J.M., Brown, R.R.: Quantitative Studies on Tryptophan Metabolism in the Pyridoxine-Deficient Rat, The Journal of Nutrition, 80: No. 1, p. 55, May, 1963.

3. Korbitz, B.C.: My Most Unforgettable Case, (Bacterial and Monilial Septicemia and Acute Renal Failure with Recovery in a 90 Year Old Woman), Denver Medical Bulletin, 22: No. 12, p. 24, 1965.

4. Korbitz, B.C., Reiquam, C.W.: Radiation Therapy in Chronic Granulocytic Leukemia, Lancet, 1:794, 1967.

5. Korbitz, B.C., Reiquam, C.W., Palmer, H.D.: Splenic Myelosuppressive Syndrome, Cancer, Vol. 22, N. 6, p. 1185, December, 1968.

6. Korbitz, B.C., Reiquam, C.W.: Busul_fan (Myleran) in Chronic Granulocytic Leukemia: A Spectrum of Clinical Considerations, Clinical Medicine, Vol. 76, No. 1, p. 16, January, 1969.

7. Davis, H.L., Murray, R.K., Korbitz, B.C.: Breast Carcinoma Metastatic to the Stomach: Report of a Case in a Male and Review of an Autopsy Series. American Journal of Digestive Disease, Vol. 13, No. 10, p. 868, October, 1968.

8. Davis, H.L., Skroch, E.E., Ramirez, G., Korbitz, B.C •. : Hemangiosarcoma of the Breast. Rocky Mountain Medical Journal, 66: No. 6, p. 49, June, 1969.

9. Korbitz, B.C., Ramirez, G., Mackman, S., Davis, H.L.: Coumarin-Induced Skin Necrosis in a Sixteen Year Old Girl, American Journal of Cardiology, Vol. 24, No. 3, pp. 420-525, September, 1969.

10. Ramirez, G., Korbitz, B.C., Davis, H.L., Mackman, S: A Comparative Study of Monthly Courses vs. Weekly Maintenance Doses of 5 FU. Abstract presented at the American Society of Clinical Oncology Meeting, 22 March 1969, in San Francisco.

11. Korbitz, B.C., Davis, H.L., Ramirez, G., Ansfield, F.J.: Low Dose Vincristine Therapy for Malignant Disease, Cancer Chemotherapy Reports, Part 1, Vol. 53, No. 4, pp. 249-254, September, 1969.

12. Korbitz, B.C., Toren, F., Davis, H.L., Ramirez, G., Ansfield, F.J.: The Piromen Test: A Useful Assay of Bone Marrow Granulocyte Reserve. Current Therapeutic Research, Vol. 11, No. 8, pp. 491-505, August, 1969.

13. Davis, H.L., Ramirez, G., Korbitz, B.C., and Ansfield, F.J.: Advanced Lung Cancer Treated with Cyclophosphamide. Disease of the Chest, Vol. 56, No. 6, pp. 494-500, December, 1969.

14. Ansfield, F.J., Ramirez, G., Davis, H.L., Korbitz, B.C., Vermund, H., and Collin, F.F.: Treatment of Advanced Cancer of the Head and Neck. (A Randomized Survival Study Comparing Results of Radiation Alone and Radiation Plus 5-Fluorouracil). Cancer, Vol. 25, No. 1, pp. 78-82, January, 1970.

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15. R.mnirez, G., Korbitz, B.C., Davis, H.L., and Ansfield, F.J.: A Comparative Study of Monthly Courses vs. Weekly Maintenance Doses of 5-Fluorouracil. Cancer Chemotherapy Reports, Vol. 53, pp. 243-249, September, 1969.

16. Ansfield, F.J., Korbitz, B.C., Davis, H.L., and Ramirez, G.: Triple Drug Therapy in Testicular Tumors. Cancer, Vol. 24, No. 3, p. 442, September, 1969.

17. Korbitz, Report.

B.C.: Massive Cavitation of the Lung in Hodgkin's Disease: A Case Chest, 58: 542-545, November, 1970.

18. Korbitz, B.C.: Tryptophan Metabolism in the Magnesium-Deficient Rat. Journal of Vitaminology, 16: pp. 140-143, June, 1970.

19. Korbitz, B.C.: The Influence of Dietary Pyridoxine on the Mortality Rate of the Magnesium-Deficient Rat. Journal of Vitaminology, 16: pp. 137-139, June, 1970.

20. Korbitz, B.C., Toren,' F., Davis, H.L., Ramirez, G., Ansfield, F.J.: The Piromen Test. Abstract presented at the International Union 1Against Cancer, Houston, Texas, May, 1970.

21. Manhart, J., Wilson, J., Korbitz, Sporothrichosis: A Case. Report.

B.C.: Noncutaneous Disseminated J.A.M.A., 214:. 365-368, Octob~r 12, 1970.

22. Del Carmen, Benjamin V., and Korbitz, B.C.: Oral Metastasis From Hypernephroma. Journal of American Geriatrics Society, 18: No. 9, pp. 743-746, September, 1970.

23. Korbitz, B.C., Ramirez, G., Mackman, S., Davis, H.L.: Coumarin Induced Skin Necrosis is True Idiosyncrasy, Modern Medicine, September 7, 1970. (Abstract of prior article in American Journal of Cardiology).

24. Correspondence: Korbitz, B.C.: Caution in Plastic Implants; Medical World News, June 19, 1970. Letters to the Editor.

25. Korbitz, B.C., Management of Anemia in Patients with Malignancy. Journal of the American Geriatrics Society, 19:41-50, January, 1971.

26. Clark, R., Korbitz, B.C., and Cline, W.: Infectious Mononucleosis Complicated by Hemolytic Anemia and Thrombocytopenic Purpura, Wisconsin State Journal, 70: 181-182, 1971.

2i. Eisner, E.V., and Korbitz, B.C.: Quinine-Induced Thrombocytopenic Purpura Due to an IgM and IgG Antibody. Transfusion, 12: 317-321, September-October, 1972.

28. Ansfield, F.J., Ramirez, G., Korbitz, B.C., and Davis, H.L.: Five Drug Therapy in Advanced Breast Cancer, A Phase I Study. Cancer Chemotherapy Reports, Part I, Vol. 55, No. 2, April, 1971, pp. 183-187.

29. Korbitz, B.C.: Management and Mechanism of Anemia in Malignant Disease, 30 minute tape recording, General Medical Seminars, Available from University Extension, The University of Wisconsin Health Sciences Unit, Department of Postgraduate Medicine.

•. Page 9

. 30.' Mackman, S., and Korbitz, B.C.: Pitfalls in the Diagnosis of Metastatic Carcinoma. Journal of Surgical Oncology, Vol. 3, No. 4, 1971, pp. 401-413.

31. Del Carmen, B.V., and Korbitz, B.C.: Hypernephroma and Oral Metastasis Reported. (Abstract) Medical Tribune, pp. 16-17, March 24, 1971.

32. Korbitz, B.C.: Therapy of Hodgkin's Disease, Lymphomas and Multiple Myeloma, (Chapter IV) in Chemotherapy of Malignant Neoplasms, 2nd edition, by Ansfield, F.J., Charles C. Thomas, Publisher, 1973. ·

33. David, H.L., Prout, M.N., McKenna, P.J., Cole, D.R., and Korbitz, B.C.: Acute Leukemia Complicating Metastatic Breast Cancer. Cancer, Vol. 31, No. 3, pp. 543-546, March 1973.

34. Korbitz, B.C.: Systemic Cat Scratch Disease with Hepatosplenomegaly, ~lultiple Lymphadenopathy and Hepatic Dysfunction. Rocky Mountain Medical Journal.

35.

Vol. 70: 23-27, June, 1973.

Korbitz, B.C.: Same Patient. July, 1973.

Three Primary Malignancies Occurring within 14 Months to the Journal of the .American Geriatrics Society, Vol 21: 330-332,

36. Korbitz, B.C.: Brief Communication: Possible Improved Technique of Skin Patch Testing. Archives of Environmental Health, Vol. 27: 409-411, December, 1973.

37. Korbitz, B.C., and Eisner, E.: "Cocktail Purpura": Quinine-Dependent Thrombocytopenia. Rocky Mountain Medical Journal, Vol. 70: 38~41, October, 1973.

38. Korbitz, B.C.: Cocktail Purpura Traced to Quinine. Modern Medicine (Abstract), p. 81, May 13, 1974.

39. Korbitz, B.C.: An Improved Method for Obtaining Histologic Sections from Bone Marrow Aspirates. (In preparation).

40. Korbitz, B.C., and Schea, S.C.: Combined Narrow Field Radiation and Systemic 5-Fluorouracil as Adjuvant Therapy Post-Mastectomy. (In preparation).

41. Korbitz, B.C.: Intravenous Diazepam and Meperidine Hydrochloride as Pre­sedation for Bone Marrow Aspirations and Biopsies: An Improved Method of Presedation. (In preparation).

42. Korbitz, B.C.: Cancer Manual for the patient and his family. (In preparation) •

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CONFERENCE LECTURES AND PRESENTATIONS '\ ' ~

1. Korbitz, B.C., and Byers, M.L.: Nursing Care of Cancer Patients Young and Old: 7th Annual Spring Cancer Conference for Nu~ses, University of Wisconsin, April 19, 1968.

2. Korbitz, B.C.: ~~nagement of Polycythemia Vera. Presented at the Eighth National Cancer Conference, University of _Wisconsin, 22 August 1968.

3. Korbitz, B.C.: Staging of Hodgkin's Disease and Its Therapeutic Implications. Presented at the Ninth National Cancer Conference, University of Wisconsin, 20 August 1970.

4. Korbitz, B.C.: The Role of Granulocyte Reserve Testing in Medical Oncology. Presented at the Denver Clinic Experiences Day, Denver, Colorado, 5 December 1970.

S. Korbitz, B.C.: The Piromen Test: A Useful Assay of Bone Marrow Granulocyte Reserves. Tenth International Cancer Congress, May, 1970, Houston, Texas.

6. Korbitz, B.C.: "The Laboratory - New Diagnostic Methods and Latest Tools for Treatments", and "The Future Management of Leukemia" (Both presented at the 23rd Annual Midwest Cancer Conference, Wichita, Kansas, 26 March 1971.

7. Korbitz, B.C.: Coumadin Skin Necrosis Syndrome. Presented at the American College of Physicians, Colorado Regional Meeting in Association with Colorado Society of Internal Medicine, Colorado Sp~ings, Colorado, 13 January 1973.

8. Korbitz, B.C., M.D., LL.B.: Medical Legal Entrapments, In-Depth Teaching Programs, St. Marys Hospital Medical Center--State Medical Society of Wisconsin, December 5, 1974, and February 13, 1975.