ageless beauty slide deck
TRANSCRIPT
Attaining Ageless Beauty
Presenter: Name, MDSpecialty: SpecialtyCity, State: Practice location
Disclosure• Speaker’s Bureau, BioForm
Medical, Inc.
Attaining Ageless Beauty
• Beauty is ethnically, racially and culturally determined.
• Universal standards of beauty– Symmetry/Proportion– Smooth, convex contours
• Female:– High cheek bones– Gentle curve from cheek to
mouth• Male:
– Strong jawline– Prominent chin
– Smooth facial skin without crow's feet, deep nasolabial folds, sagging neck, jowls or upper/lower lid bags/wrinkles.
Facial Aesthetics
Henri Gaboriau, MD, Seattle, WA
Today’s Concept ofFacial Beauty
• Surface changes– Changes in skin pigmentation and texture
• Photo-damage• Trauma• Medications• Endocrine
The Process of Aging
• Subsurface Changes– Volume loss
• Soft tissue loss– Dermal atrophy– Muscle atrophy– Fat redistribution– Atrophy in the subcutaneous compartment
• Hard tissue loss– “Biometric volume loss”– Resorption of underlying bone, cartilage,
dentition
Werschler WP, Cosmetic Dermatology, Nov 2007, Vol 20 No 11
The Process of Aging
Facial Aging
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• Biometric Volume Loss/Alteration: BVL/A– “The cumulative effect of loss and
redistribution of biologic volume that can be measured”
– Shrinkage of time– Intrinsic component of the aging face
• Photo-damage is the (major) extrinsic component
Aging and BiometricVolume Loss
• Treating BVL/A for aesthetic improvement– Assess zones of the face for treatment– Visualize outcome
• Balance• Proportion• Symmetry
– Plan: Re-Volumization– “Pyramid of Age” to “Triangle of Youth”
New Approaches:Fillers and Toxins
• Restore volume• Contour facial anatomy• Compared to surgical procedures
– less invasive– low risk– little to no down time
• Cost effective
Dermal Fillers
Areas for Use of Dermal Fillers
Marionette Line
Nasolabial Fold
Malar Eminence/Zygomatic Arch
Mental Crease
Chin/MentumJawline/Pre-Jowl
Oral Commissure
Nasal Tip
Nasal Dorsum
InfraorbitalSub-Malar Area
Lateral Chin
Glabella
Upper
Mid
Lower
Lips
Lateral Brow
• Replacement vs. Stimulatory• Immediate vs. Delayed• Time limited vs. Permanent• Synthetic vs. Natural• Global vs. Local
Evolution of Fillers
• Product categories have become blurred
• No single simple classification system
• Most systems look @ MOA– Space occupying – Growth stimulating– Permanent implant
• “Replacement and/or Stimulatory”
Evolution of Fillers
• Utility of products has evolved– Wrinkle and line filling = old– Facial shaping = new– Approach is global balance,
symmetry, proportion
Evolution of Fillers
• Structure & Support• Regional Volume & Contouring
Evolution of Facial Filling
• RAVE– A method of assessing, planning
and performing volume enhancement to replace BVL
– A technique concept– Uses fillers to re-harmonize each
zone of the face
Regional Aesthetic Volume Replacement
Werschler WP, Cosmetic Dermatology, Nov 2007, Vol 20 No 11
• Contouring regional areas requires a filler that has:
– Robust strength– Longevity– Durability – Safety
RAVE
Werschler WP, Cosmetic Dermatology, Nov 2007, Vol 20 No 11
IFUs for Zyderm, Zyderm 2, Zyplast, CosmoDerm, Comoplast
Short-Term: Collagen Commercially AvailableConcentration of
CollagenIndications Size of
Syringe Available
Placement Degree of Overcorrectio
nZyderm 35 mg/mL bovine Fine lines: perioral,
periocular, glabellar0.5, 1.0, 1.5mL Superficial
papillary dermis150-200%
Zyderm 2 65 mg/mL bovine Mid to moderate rhytids: scars,
perioral
0.5, 1.0 mL Mid-dermis 100-150%
Zyplast 35 mg/mL Cross-linked with
gluteraldehyde bovine
Deeper rhytids and folds: nasolabial,
vermilion, marionette lines
1.0, 1.5, 2.0, 2.5 mL
Deep dermis No overcorrection
CosmoDerm 35 mg/mL human-derived
Fine lines: perioral, periocular, glabellar
1.0 mL Superficial papillary dermis
150-200%
Cosmoplast 35 mg/mL Cross-linked with
gluteraldehyde human-derived
Deeper rhytids and folds, nasolabial,
vermilion, nasolabial folds
1.0, 1.5 mL Deep dermis No overcorrection
IFUs for Juvederm™ Ultra, Juvederm ™ Ultra-Plus, Restylane®, Perlane®
Short-Term: Hyaluronic Acids
Juvederm™ Ultra Juvederm™ Ultra-Plus Restylane® Perlane®
HA Concentration
24 mg/mL 30 mg/mL 20 mg/mL 20 mg/mL
Durability 6+ months 6+ months 6 months 6+? Months
Needle 30g 0.5” 27g 0.5” 30g 27g
Level of Injection
Mid-dermis Mid to deep dermis Mid-dermis Deep dermis to Sub-Q
Indications Medium nasolabial folds, radial lip lines, medium
wrinkles, marionette lines
Nasolabial folds, cheek augmentation, lip
augmentation, marionette lines
Mild to moderate lines and folds
Deeper lines and folds, contouring, volumizing
• Polymethyl-methacrylate• PMMA microspheres in 3.5% bovine collagen
with 0.3% lidocaine– acts like a scaffold to allow fibroblast in-growth and
collagen production• Skin testing required• Injection plane: immediate subdermis or deepest
dermal level• Indicated for correction of nasolabial folds• Conservative treatment protocol
– Bring to correction over several treatments• Commercially available
– Artefill®
IFU for Artefill®
Permanent Fillers
Best of both worlds?– Long lasting– Not Permanent– Correct facial folds and wrinkles– Volumize– Stimulate collagen production
Semi-Permanent Fillers
Schweiger et al, Cosmetic Dermatology, May 2007, Vol 20 No. 5
Semi-Permanent Fillers
Poly-L-Lactic Acid Calcium Hydroxylapatite
Packaging Vial of Lyophilized PLLA Prefilled 1.3 mL and 0.3 mL Syringes
Injection Site Deep Dermis/Subdermis Deep Dermis/Subdermis
FDA Status HIV-Associated Facial Lipoatrophy Correction of Moderate to Severe Lines and Folds
HIV-Associated Facial LipoatrophyAverage Treatment
Sessions3-5 1
Onset =2 months post-injection Immediate
Duration of Correction 12 - 24 months 12 - 18 months
Adverse Reactions Local AE’s (ecchymoses, pain); Nodule Formation in 3% - 44%
Local AE’s (ecchymoses, pain)
• PLLA, sodium carboxymethylcellulose, non-pyrogenic mannitol
• Skin testing not required• Stimulates collagen production over
extended period of time• Volumizer• Must reconstitute prior to use• Treat to correction over several sessions• Commercially available: Sculptra®
Poly-L-Lactic Acid
Wm. Philip Werschler, MD, Spokane, WA
PLLA Volumizing
• CaHA microspheres uniform in 25-45 um diameter (30%) suspended in carboxy-
methylcellulose gel carrier (70%)• Skin testing not required, biocompatible• Stored at room temperature in ready to use
syringes 1.3 and 0.3 cc size• No special handling requirements• Commercially Available: Radiesse®
Calcium Hydroxylapatite
• When placed into soft tissue, Gel + CaHA particles provides immediate correction due to volume injected
• Over time the gel is resorbed and the CaHA particles stimulate the body to produce collagen– Collagen + CaHA
Particles
Calcium Hydroxylapatite
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David Goldberg, MD, New York, NY
40x mag 40x mag
Picrosirius Red Type I Collagen
6 month human dermal explants
CaHA StimulatesNew Collagen Production
CaHA particles are slowly dissolved into calcium and
phosphate ions through normal metabolic processes
CaHA particles post-implantation
CaHA Particles Break Down Naturally
• FDA approved indications– Correction of moderate to severe lines and folds,
such as nasolabial folds, marionette lines, mental crease, etc.
– Correction of the signs of facial wasting resulting from HIV-associated facial lipoatrophy.
• Inject sub-dermis to pre-periosteal• Needle length: 27g 0.5”-1 ¼”, 28g .75”
Calcium Hydroxylapatite
– Nasolabial Folds– Marionette lines– Oral Commissures– Mental Crease– Malar and Submalar– Hands– Nasal Augmentation
– Infraorbital rim– Prejowl sulcus– Chin contouring– Acne scars– Deep glabellar
furrows– Lateral brow– Tear trough
Busso M, Cosmetic Dermatology, Vol. 19, No. 6, September 2006; Graivier M, Plastic and Reconstructive Surgery, Vol. 120, Supplement, November 2007; Busso M, Dermatologic Therapy, Vol 20, 2007; Dayan S, ENT Journal, Vol 86, January 2007
• Not Recommended– Above inferior orbital rim
CaHA Treatment Areas
Smith et al., Dermatogolic Surgery 2007, 33:S112-S121
CaHA Adverse Events
117 Patient RADIESSE vs Cosmoplast Study
100 Patient HIV-Associated Lipoatrophy Study
RADIESSE Total Reporting Symptoms
N(%)
CONTROL Total Reporting Symptoms
N(%)
RADIESSE Total Reporting Symptoms N(%)
Ecchymosis 74 (63.2) 50 (42.7) 65 (65.0)
Edema 81 (69.2) 52 (53.0) 99 (99.0)
Erythema 78 (66.7) 84 (71.8) 57 (57.0)
Granuloma 0 (0.0) 0 (0.0) 0 (0.0) Zero Granulomas
Needle Jamming 0 (0.0) 0 (0.0) 0 (0.0)
Nodule 1 (0.9) 1 (0.9) 0 (0.0) 0.9% Nodules
Pain 33 (28.2) 26 (22.2) 39 (39.0)
Pruritis 21 (18.0) 24 (20.5) 21 (21.0)
Treatment for Successful Outcomes
• Many different types of anesthesia can be used in filler injections:• Topical anesthetics• Nerve blocks• Tissue infiltration• Mixing lidocaine with material • Skin cooling
• Make your patient comfortable- it is recommended to provide some level of local anesthesia
• This reduces patient pain and anxiety about their procedure and makes the experience more pleasant
Anesthetic Options
• Why and Where– Adjust the cohesiveness of CaHA to use it as
a layering rather than a bulking filler• NLF, ML, etc.• Mid-face, cheeks • Hands• Temporal
– Provide a less-painful alternative– Prevents the need for anesthetic blocks
during the procedure
Lidocaine Mixing: CaHA
• 0.15 cc of 2% plain Lidocaine• Luer lock-to-luer lock connector (Baxa) • 3 cc syringe• Transfer CaHA to syringe containing
anesthetic and mix by “swishing” back and forth
• For a homogeneous mixture throughout the syringe, mix back and forth 10 times
• The mixing needs to occur immediately before injection
• Dispose of unused product, do not save
Busso M, et al, Dermatol Ther. 2007 Nov-Dec;20(6):385-7
Lidocaine Mixing: CaHA
Susan Weinkle, MD, Bradenton, FL
Lidocaine Mixing Technique
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• Results are best when CaHA is laid down in fine threads (LINE FILLING) or in and placed in the dermis: sub-cutaneous junction (aka, subdermal plane)
• CaHA is also successfully placed in the subcutaneous to supraperiosteal space to fill in deep depressions or to obtain a volume effect (LINEAR THREADS OR SMALL BOLUSES)
Subdermal PlaneSub-Q
Where is CaHA Injected?
CaHA
Depth of injection is dependent
on area being augmented• Deep dermis/subdermal plane for treating a lines
– Nasolabial folds, marionette lines, mental crease, etc.– Retrograde linear threading of material
• Subcutaneous/supraperiosteal for restoring volume resulting from skeletal loss or if placing material against bone– Mid-face: infraorbital and malar, submalar, pre-jowl sulcus,
etc.– Retrograde linear threading or bolus injections
• The trend is towards treating ZONES of the face rather than distinct lines and wrinkles
• Historically, using fillers to efface discreet lines has been the approach of most practitioners
• This focuses on injecting fillers directly into the line
• CaHA placement in the tissues for effacing distinct lines should be in the subdermal plane with linear threads
Werschler WP, Cosmetic Dermatology, Nov 2007, Vol 20 No 11
Best Techniques forBasic Filling
Using 0.75” 1.25” or 1.5” Needle Using 0.5” Needle
CaHA: Nasolabial Folds
27- or 28-gauge needle appropriate
Before Immediately After(1.3 cc total)
6 MonthsHenri Gaboriau, MD, Seattle, WA
CaHA: Nasolabial Folds
Samuel Lam, MD , Dallas, TX
Before After 6 months0.4 cc per side
CaHA: Marionette Lines
Before
After 16 months
CaHA: Pre-Jowl Sulcus
Michael Jasin, MD Tampa, FL
• Re-volumize to address loss of volume due to aging process– vs. filling individual lines
• Ideal for the mid and lower face • An ideal filler for volumizing would be
one that provides:– Strength– Longevity– Durability– Safety– Natural feel
Werschler WP, Cosmetic Dermatology, December 2007; Vol 20, No 12.
Advanced Techniques for Filling
Before After 10 months1.6 cc total
Peter Karlsberg, MD, Ventura, CA
CaHA: Peri-Oral Volume Restoration
Before After*Note change in NLF correction with only mid-face volume restoration
Michael Jasin, MD, Tampa, FL
Re-volumizing Mid-face Improves NLFs
• Ideally suited for re-volumizing and enhancing facial contours– Has tissue expanding plus collagen-inducing
properties– Triple effect
• Filling• Lifting• Pulling
– Semi-permanent• Longevity
Busso M, Cosmetic Dermatology, Vol. 19, No. 6, September 2006
Advanced Injection Techniques: CaHA
Depth of injection facial map
Marionette Line
Nasolabial Fold
Malar Eminence/Zygomatic Arch
Mental Crease
Chin/MentumJawline/Pre-Jowl
Oral Commissure
Nasal Tip
Nasal Dorsum
InfraorbitalSub-Malar Area
Lateral Chin
Glabella
Upper
Mid
Lower
Lateral Brow
Subdermal
Subcutaneous/Supraperiosteal
• Outline area to be treated with patient upright (optional)
• Use conservative amounts of anesthetic for field infiltration so as not to distort tissue
• 1.25” or 1.5” 27g needle • Place material in subcutaneous
to supraperiosteal space• Inject multiple threads of
material in a retrograde manner (~0.05 cc/thread)
• Layer additional threads in deeper plane (Sub-Q) to provide volumizing effect
• Mold as needed, but be gentle with the tissue
CaHA: Malar/Zygomatic Augmentation
Henri Gaboriau, MD, Seattle, WA
Depth of needle placement
CaHA: Malar/Zygomatic Augmentation
Before 4 Months(2.6 cc total)
10 Months
CaHA: Malar/Zygomatic Augmentation
Henri Gaboriau, MD, Seattle, WA
• Treat the entire zone to provide volume and create a natural appearance
• Areas- Inferior lateral orbital rim
Malar eminence Infraorbital hollow• Try to achieve a blending
between the lower eyelid, nasolabial fold, and the cheek
• Injection depth: Deep– subcutaneous/supraperiosteal
• Linear threads or small boluses
Mariano Busso, MD, Miami, FL
Mid-Face Volume Replacement
• Outline area to be treated with patient upright (optional)
• Make the patient comfortable- infraorbital block and field infiltration into areas to be injected or lidocaine mixing
• In using field infiltration use conservative amounts so as not to distort tissue
• 1.25” or 1.5” 27g needle • Place material in subcutaneous to supraperiosteal
space and stay below the inferior orbital rim• Inject multiple threads or boluses• Mold as needed, but be gentle with the tissue
Mid-Face Volume Enhancement
Mid-Face Volume Enhancement
Copyright © 2008 BioForm Medical, Inc.
Before After 9 months(2.0 cc/cheek)Miles Graivier, MD, Roswell, GA
Mid-Face Volume Enhancement
Before After 6.5 ccMariano Busso, MD, Miami, FL
Mid-Face Volume Enhancement
• DO NOT inject above the inferior orbital rim • Amount placed may not be identical for each
side due to asymmetry• At the completion of the procedure, the area
should be free of nodularity and feel smooth• Swelling is to be expected, do not overcorrect as
more can always be added later• Apply cold packs/ice to the treated areas and
continue at home to reduce bruising and swelling
Pearls for the Mid-Face
• Immediate outcome : improvement immediate• Provides augmentation lasting a year or more in
most patients• Adverse event profile is minor and similar to other
injectables• The firmness of the injected material will soften by
2 weeks and it will become like the resident soft tissue
• The patients are ecstatic with the immediate result and this contributes to a positive quality of life
Pearls for the Mid-Face
• Young face, “experienced” hands• Hands subject to same aging process as
faces• Subsurface Changes
– Volume loss• Soft tissue loss
– Dermal atrophy– muscle atrophy– fat redistribution– Atrophy in the subcutaneous compartment
Hand Rejuvenation
• While tenting skin, needle is placed in areolar plane between subcutaneous and superficial fascia layers
• Avoid injecting into extensor tendons and their synovial sheaths, retinaculum and muscles
• Can inject small or large boluses• Material is easily moldable• Some moderate swelling is normal and will
resolve within 1-3 weeks• Results tend to improve over 2-4 weeks
Busso M, Applebaum D, Dermatologic Therapy, Vol 20, No 6, Nov-Dec 2007
Hand Rejuvenation: CaHA
Michael Jasin, MD, Tampa, FL
Hand Rejuvenation: CaHA
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Before Immediately After 1.3 ccMichael Jasin, MD, Tampa, FL
Hand Rejuvenation: CaHA
Live Patient Treatment Demonstrations