ageloc science year in review 2010

8/3/2019 AgeLOC Science Year in Review 2010

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2010ageLOC Science

year in review


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16 Total Patents

2 Awards Received

4 Published Scientific Articles

9 Oral Presentations14 Scientific Posters

AGELOC SCIENCE

IS A GLOBALPHENOMENON


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Barcelona,Spain

Berlin,Germany

Bangkok,Thailand

New York,NY USA

Nu Skin, with ageLOC science, stands apart from the competition becauseour approach is based upon 30 years of breakthrough anti-aging research.Our research continues to gain recognition and is validated throughpresentations at global scientific conferences.Joe Chang, Ph.D.

Santa Barbara,CA USA

Anaheim,

CA USA

Atlanta,

GA USA

Brussels,Belgium

Helsinki,Finland

Les Diablerets,Switzerland

Tokyo,Japan

Buenos Aires,Argentina

Singapore,China


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ageLOC Science2010 Timeline


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JANUARY

AppointedDr. Stuart Kimto Nu SkinAnti-AgingScientificAdvisory Board

MARCH

PresentedNutritional Researchat Oxygen Club of California2010 World Congress

AwardedDSM Nutraceutical

Research AwardPresentedat New York Society ofCosmetic Chemists Meeting

PresentedarNOX Research at OxygenClub of California 2010World Congress

FEBRUARY

InitiatedFull-scaleclinical trial onageLOC Vitality

ConductedFirst pre-clinicalstudy on ageLOC

CompletedFirst heatmap validatingageLOC nutritional science


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APRIL

Presented

Presented 4Studies atExperimentalBiology 10

MAY JUNE

Presentedat CoLONGYConference

Presented

Research at 40th AnnualEuropean Society forDermatological Research

SubmittedProvisional Patenton ageLOC Vitality

PresentedResearch atInternational CoenzymeQ Association Meeting

Two additional patent submissions,one in 2010 and another in 2011,confirm the credibility of ageLOCscience and our commitment todeveloping and protecting our IPas we pioneer this new area ofanti-aging science. We are takinganti-aging products to the next leveland are ensuring exclusivity forour distributors.Steve Wood, Ph.D.,Director of Global Research, Pharmanex

"With research in the anti-agingindustry rapidly evolving, we werehonored to present at CoLONGY2010the First InternationalCongress on Controversies inLongevity, Health, and Aging.This conference was devoted totopics on aging, and it was anexciting opportunity for us topresent our research supportingageLOC science.Jamie Barger,Ph.D., LifeGen Technologies


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JULY

Published

Article in

Cosmeticsand Toiletries

PresentedResearch at Society forInvestigative Dermatology

PresentedResearch at Biology ofAging Gordon ResearchConference

AUGUSTSEPTEMBER

PublishedArticle in Journal ofCosmetic Science

PublishedArticle in Journal of

Cosmetic DermatologySponsoredUniversity of TokyoScience Symposium

The SID is committed to fostering publication of innovative, cuttingedge science from prominent researchers in skin biologyand encouraging scientific collaborations among researchersworldwide. The findings presented at this meeting were newgenetic research that was peer reviewed and accepted forpublication.Helen Knaggs, Ph.D., Vice President, Nu Skin GlobalResearch and Development


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LaunchedFirst ageLOCNutrition ProductageLOC Vitality

OCTOBERSEPTEMBER continued

PresentedarNOX Research at

International Federationof Societies of CosmeticChemists

PresentedYouth Gene ClusterResearch at InternationalFederation of Societies ofCosmetic Chemists

Presentedat University of TokyoScience Symposium


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PublishedArticle in Anti-AgingMedical News

Presentedat Society of CosmeticChemists Annual Meeting

NOVEMBER

2 Presentationsat First World Congresson Targeting Mitochondria

Presentedat In-CosmeticsAsia Conference

Presentedat Asian CosmeticChemistry Society

DECEMBER

AwardedYoung Scientist ofthe Year by Societyof Cosmetic Chemists

In-Cosmetics is a prestigiousglobal organization and is touted

as the leading exhibition for

personal care ingredients.Being chosen as a speaker atthe anti-aging session is anhonor and signifies globalrecognition for Nu Skin as aleader in anti-aging science inthe personal care industry.Helen Knaggs, Ph.D., Vice President,

Nu Skin Global Research and Development


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ageLOC SciencePublications andPresentations


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Patent Submission Awards Journal Articles

FULL LIST

May 2010Provisional Patent on Vitality# 01336-36004, ORAL FORMULATIONSFOR COUNTERACTING EFFECTSOF AGING. Submitted May 24, 2010.Barger, J.L., Mastaloudis, A., Prolla, T. A.,Weindruch, R., and Wood, S.M.

Angela Mastaloudis,Senior Scientist, Receivedthe DSM NutraceuticalResearch Award

Remona Gopaul, AssociateSenior Scientist, Named

Young Scientist of theYear by the Society ofCosmetic Chemists

July 2010

Reducing skin stress response with willowbark-derived salicin, Cosmetics andToiletries (July, 2010): 32-36. Gopaul, R.,Knaggs, H., and Langerveld, A.

September 2010

Impact of Scientific Innovations on thePersonal Care Industry, Journal of CosmeticScience, 9(3) 2010; 260-263. Knaggs, H.

An evaluation of the effect of a topicalproduct containing salicin on the visible signsof human skin aging, Journal of CosmeticDermatology, 9(3) 2010; 196-201. Gopaul, R.,Gibson, M., Knaggs, H., Holley, K.C., andLephard, J.

December 2010

Nutritional and genetic strategies forlongevity. Anti-Aging Medical News. Winter2010:36-40. Bartlett, M.


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Oral PresentationsMarch 2010

Resveratrol mimics caloric restriction and retardsaging in the heart. Oxidents and antioxidants inbiology, Oxygen Club of California World Congress,March 17-20, 2010, Santa Barbara, CA. Prolla, T.

Aging and Genesthe Link with Skin.

New YorkSociety of Cosmetic Chemists Meeting, Helen

Knaggs.

June 2010

Transcriptional biomarkers of age and theirmodulation by dietary intervention. CoLONGY, The1st International Congress on Controversies inLongevity, Health and Aging. Barcelona, Spain, June24-27, 2010. Barger, J., Wood, S.M., Weindruch, R.,and Prolla, T.

August 2010

Transcriptional Biomarkers of Mitochondrial Agingand Modulation by Cordyceps SinensisCs-4.Gordon Conference, Les Diblerets, Switzerland,August 21-27, 2010. Wood, S.M., Barger, J., Prolla, T.A., Weindruch, R., Mastaloudis, A., and Ferguson, S.

September 2010

Mitochondria and Aging. Japan Symposium.Mechanisms of Ageing and Development2010;13:449-450;480-486. Prolla, T.

November 2010

A nutritional strategy to oppose the genetic

expression of aging and loss of vitality. 1stWorld Congress on Targeting Mitochondria,Strategies, Innovation and Clinical Applications,Berlin, Germany, November 18-19, 2010. Wood,S. M., Ferguson, S. B., Barger, J. L., Prolla, T.A., Weindruch, R., and Bartlett, M.

Targeting age-related gene expressionimproves mental and physical vitality. 1st WorldCongress on Targeting Mitochondria, Strategies,Innovation and Clinical Applications, Berlin,

Germany, November 18-19, 2010. Ferguson, S.B., Tan, N., Dong, Y., Lu, J., Fisk, N.A., Wood,S.M., Zhu, J., and Bartlett, M.

Genes and Aging: Links to Skin,In-Cosmetics Asia; Bangkok,Thailand, Helen Knaggs.

Why Do People Look Younger forTheir Age, Asian Cosmetic

Chemistry Society; Singapore,China, Helen Knaggs.

December 2010

A Review of Current GenomicTechniques Used in GeneExpression Profiling of the Skin,Society of Cosmetic ChemistsAnnual Meeting; New York, NewYork, Remona Gopaul.

FULL LIST


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Posters

FULL LIST

March 2010

Antioxidation and lifespan-extension activities ofCordyMax in oxidative stress and aging models #A177.Oxidants and Antioxidants in Biology, Oxygen Club ofCalifornia World Congress, March 17-20, 2010, SantaBarbara, CA. Zhu, J., Zhang, Y., Yang, J., Tan, N., Zhao,C., and Mastaloudis, A. (presenter; received DSMResearch Award)

Age-Related Oxidase (arNOX) Implicated in

Aging-Related Oxidative Damage to SkinProteins,Oxygen Club of California, 2010 WorldCongress, Santa Barbara, California. Morr, D. M., Morr,D. J., Meadows, C., Draelos, Z., andKern, D. G.

April 2010CordyMax extends the lifespan in an aging model: apreliminary report, Abstract #A310. ExperimentalBiology 10, April 24-28, 2010 Anaheim, CA. Tan, N.,Zhang, Y., Yang, J., Zhao, C., and Zhu, J. S.

Improvement of exercise metabolism and carotenoidantioxidant scores with CordyMax and LifePak in youngChinese elite athletes, Abstract #D356. ExperimentalBiology 10, April 24-28, 2010 Anaheim, CA. Duan, L.,Zhao, L., Liang, C., Lu, L., Gao, L., Li, G., and Zhu, J.S.

Maturational alteration of differential expressionsof GC:AT-biased genotypes of Cordyceps sinensisfungiand Paecilomyces hepialiin Cordyceps sinensis, Abstract#B210. Experimental Biology 10, April 24-28, 2010Anaheim, CA. Zhu, J. S., Gao, L., Yao, Y., and Zhou, Y.

Antioxidation activities of CordyMax in an oxidativestress model: a mechanism of its anti-aging properties,Abstract #311. Experimental Biology 10, April 24-28,2010 Anaheim, CA. Yang, J., Tan, N., Zhao, C., Zhang, Y.,and Zhu, J. S.

May 2010

Appearance in Japanese Women Correlates with Age-

Related NADH Oxidase Levels and Blood Markers ofLipid Oxidation,Society for Investigative Dermatology; J.Invest Dermatol 130. S. 6 (2010). Morr, D. J., Morr, D.M., Kern, D. G., and Wood, S. M.

Regulating the Expression of Genes Associated with theSynthesis and Maintenance of Dermal Hyaluronan andBarrier Lipids Via Topical Treatment of SalicinAn InVitroAnalysis, Society for Investigative Dermatology; J.Invest Dermatol 130. S. 84 (2010). Gopaul, R. andKnaggs, H.

Salicin Regulates the Expression of Functional Youth

Gene Clusters to Reflect a More Youthful Skin Profile,International Federation of Societies of CosmeticChemists Annual Meeting, Buenos Aires, Argentina.Gopaul, R., Langerveld, A., Knaggs, H., and Lephart, J.

Inhibition by Coenzyme Q10 of Age Related Oxidase(arNOX) Caused Oxidative Damage in Skin Proteins,International Coenzyme Q Association Meeting, Brussels,Belgium. Morr, D. M., Morr, D. J., Meadows, C.,Draelos, Z., and Kern, D. G.

June 2010

Appearance in Japanese Women Correlates with thePresence of Inosotides and Lysolipids, Both SignificantInhibitors of Age-Related NADH Oxidase Levels,40thAnnual European Society for Dermatological Research,June 2010. Morr, D. J., Morr, D. M., Kern, D. G., Wood, S.M., Toyoda, H., and Knaggs, H.

August 2010

Transcriptional Biomakers of Mitochondrial Aging andModulation by Cordyceps Sinensis Cs-4.Gordon

Conference, Les Diblerets, Switzerland, August 21-27,2010. Wood, S.M., Barger, J., Prolla, T. A., Weindruch, R.,Mastaloudis, A., and Ferguson, S.

September 2010

Anti-Aging Effects of Superoxide Reduction in Skin by theApplication of Specific Inhibitors of Age-Related NADHOxidase (arNOX), International Federation of Societies ofCosmetic Chemists, Buenos Aires, Argentina. Kern, D. G.,Meadows, C., Fuller, B. B., Knaggs, H., Morr, D. M., andMorr, D. J.

Salicin Reduces the Expression of Genes Associated withSkin InflammationAn In VitroAnalysis, Society forInvestigative Dermatology; J. Invest Dermatol 130. S. 85(2010). Gopaul, R. and Knaggs, H.


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summaryNu Skin scientists and our scientific partners have just concluded abreakthrough year, building our body of knowledge in anti-aging researchat an accelerating rate with more than 20 presentations at 11 prestigiousconferences and symposia around the world.

We believe Nu Skins ongoing research, combined with our researchpartnerships, including LifeGen Technologies, will deepen the companys

understanding of gene expression and its impact on reversing the effects ofaging even later in life.

With our exclusive focus on identifying, targeting, and resetting YouthGene Clusters, we believe ageLOC science is the answer to anti-aging.Its a scientific breakthrough that goes beyond the signs to target theultimate sources of aging.

For more information about ageLOC science, please visit ageloc.com.


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ageloc science year in review 2010

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