AGENDA for 03/03/14

• AGENDA:

1. 3.4.1. Family Inheritance

2. 3.4.1. Online Conclusion Quiz

• OBJECTIVES:

1. Analyze gel electrophoresis

results

2. Create a pedigree showing

the occurrence of a trait in a

family

• HOMEWORK:

• Due end of period

1. 3.4.1 Activity Packet

• Due Fri, 03/07

1. 3.4.2 Career Journal

• Unit 3 Exam on Tues, 03-11

3.4 Key Terms

1. Allele

2. Chromosome

3. Dominant Trait

4. Gene

5. Genotype

6. Heredity

7. Pedigree

8. Phenotype

9. Punnett Square

10.Recessive Trait

Essential Questions for 3.4.1

1. How are pedigrees used to track diseases?

2. Why does sickle cell disease run in families,

yet is not present in every generation?

Activity Objectives – 3.4.1.

1. Analyze the gel electrophoresis results

obtained from the Restriction Fragment

Length Polymorphisms of Anna Garcia’s

family members

2. Create a pedigree for Anna Garcia depicting

the occurrence of sickle cell anemia within

her family

Patterns of Inheritance: Pedigrees

Patterns of Inheritance

• Genetic diseases and other phenotypes can be

traced back through a family’s medical history

• This is useful as it can help healthcare

professionals assess the probability of a

person having a genetic disorder

Pedigree Charts

• Pedigree charts show the appearance of a

particular gene through phenotypic

expression from one generation to the next

• Pedigrees only show the phenotype, not the

genotype.

• Often, particular symbols are used to

represent the sex of the person, the

relationships between 2 or more people and if

a person is expressing the particular

phenotype

Pedigree Chart Symbols

Pedigree Chart Example

• This chart shows the presence of the rolled or non-rolled tongue. The non-rolled tongue is recessive. The blackened symbols represent those with non-rolled tongues.

Some helpful tips for analyzing

pedigree charts

1. If neither parent show the trait:

a. the trait cannot be dominant.

b. the trait could be recessive and either parent or both could be

heterozygous carriers.

2. If one parent shows the trait:

a. the trait could be dominant and the affected parent could be

heterozygous while the unaffected parent is not a carrier

b. the trait could be recessive and the affected parent is homozygous

while the unaffected parent could be a heterozygous carrier

3. If both parents show the trait:

a. the trait could be dominant and both parents could be heterozygous

carriers which means that some of the children could be unaffected

b. the trait could be recessive meaning that both parents would have to

be homozygous and all the children would have to be affected

3.4.1 Activity Checklist

1. 3.4.1. Pedigree Notes (NB) STAMP

2. 3.4.1. Pedigree Resource Sheet (NB)

3. Pedigree Worksheet

4. 3.4.1. Gel Electrophoresis Analysis (NB)

5. 3.4.1. Garcia Family Pedigree Chart (NB)

• 3.4.1. Online Conclusion Quiz

1

Total = 10

3

15

2

2

2

3.4.1. Activity Directions

3.4.1. Pedigree Notes (NB)

1. Go through the PowerPoint notes on Patterns of

Inheritance: Pedigree

2. Visit the website:

http://www.dnalc.org/view/15913-The-

pedigree.html. Go through the interactive

presentation on the pedigree.

3. Take all your notes in your NB

4. Label each part of the notes clearly.

5. Get a stamp for the notes (do not include notes

with the packet when you turn it in)

3.4.1. Pedigree Resource Sheet (NB)

1. Refer to curriculum file for more detailed

instructions

2. Refer to steps 1-2

3. Open the Pedigree Resource sheet on the website.

4. Read through the sheet.

5. Answer all the Check for Understanding questions.

6. This will be turned in with your packet (no stamp).

7. Label this clearly.

Pedigree Worksheet

1. Obtain a Pedigree Worksheet

2. Complete this worksheet, answering all questions

clearly and completely.

3. This will be turned in with your packet (no stamp).

3.4.1. Gel Electrophoresis Analysis (NB)

1. Refer to curriculum file for more detailed instructions

2. Refer to step 3

3. Analyze the gel in the curriculum file of Anna’s family members

4. If you forgot RFLP, go back to unit 1, and under 1.2.3 activity, click on Restriction Fragment Length Polymorphism notes, and review the concepts.

5. Draw (copy) the gel onto your NB. Do not print.

6. Determine:a. Which members have sickle cell anemia

b. Which members have carriers

c. Which members are unaffected

7. Explain why you can to these conclusions.

3.4.1. Garcia Family Pedigree Chart (NB)

1. Refer to curriculum file for more detailed instructions

2. Refer to step 4

3. Create a pedigree chart of the Garcia family of the pattern of inheritance of sickle cell anemia in that family using the results of your gel analysis

4. Correctly label

1. Each generation

2. Each person

3. The sex of the person

4. If the person is affected, a carrier, or unaffected

3.4.1. Conclusion Questions

1. Why is sickle cell anemia classified as a recessive

disorder?

2. If Anna had a child with a man with sickle cell

anemia, predict whether that child would also have

sickle cell anemia. Explain the reasoning and

describe the information you used to make your

prediction.

3.4.1. Online Conclusion Quiz1. Instead of answering Conclusion Questions, you will take an

online quiz on the questions at the end of the activity

2. After the activity, reflect on the questions and the objectives of the activities

3. Prepare responses to:a) Essential Questions

b) Conclusion Questions

c) Questions about Key Terms

d) Questions about the activities

e) Your thoughts and explanations

4. Go to http://quizstar.4teachers.org/

5. Follow directions to create an account

6. Each person will logon and take the quiz

7. A score will be generated at the conclusion of the quiz

3.4.2. Career Journals

1. Refer to curriculum file for more detailed instructions.

2. The career journals will be turned in separately and scored separately from this activity packet

3. Refer to steps 20-22

4. You will research the following career:

1. Clinical Geneticist

5. Due Fri, 03-07 (turned in separately)

• Next slide has instructions for the correct formatting of your career journals

• Worth 5 points each

3.4.2. Career Journals

1. Correct Title– All CAPS

2. Education and Training– include all required degrees,

field and major of study

– Specific types of certifications, licensing, or training

– Time/years of study

– Bullet each of the above

3. Responsibilities and Duties– Bullet each responsibility and

duty starting with a verb (action word � leave out the subject)

– Must include at least 5

4. Salary– Low

– High

– Average

5. Documentation– At least 2

– Must use .edu, .gov, .org (.com only if approved by Mr. Hwang first)

– Must be in correct APA format

6. Self-Reflection– Summary of the description of

job

– 1 advantage of job

– 1 disadvantage of job

– Reason you would like or dislike the job