alcl3 mediated three component cyclocondensation for the synthesis of 5-unsubstituted...

2006 Pyrimidine derivatives R 0510 AlCl 3 Mediated Three Component Cyclocondensation for the Synthesis of 5-Unsubstituted 3,4-Dihydropyrimidin-2(1H)-ones. — The facile one-pot synthesis of the title compounds (IV) (9 examples) involves the use of enolizable ketones like acetophenone, instead of 1,3-dicarbonyl compounds as used in the classical Biginelli reaction, and the bimetal system AlCl3/KI. — (SAINI, A.; KUMAR, S.; SANDHU*, J. S.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 45 (2006) 3, 684-688; Dep. Chem., Punjabi Univ., Patiala 147 002, India; Eng.) — H. Toeppel 26- 139

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Page 1: AlCl3 Mediated Three Component Cyclocondensation for the Synthesis of 5-Unsubstituted 3,4-Dihydropyrimidin-2(1H)-ones

2006

Pyrimidine derivativesR 0510 AlCl3 Mediated Three Component Cyclocondensation for the Synthesis of

5-Unsubstituted 3,4-Dihydropyrimidin-2(1H)-ones. — The facile one-pot synthesis of the title compounds (IV) (9 examples) involves the use of enolizable ketones like acetophenone, instead of 1,3-dicarbonyl compounds as used in the classical Biginelli reaction, and the bimetal system AlCl3/KI. — (SAINI, A.; KUMAR, S.; SANDHU*, J. S.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 45 (2006) 3, 684-688; Dep. Chem., Punjabi Univ., Patiala 147 002, India; Eng.) — H. Toeppel

26- 139

Synthesis of 3, 4-Dihydropyrimidin-2 (1H)-Ones and Their

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