1. Aldactone Spironolactone TabletsAldactone Tablets are used to treat hypertension,oedematous disorders, diagnosis and treatment ofprimary aldosteronism, reducing or preventingpotassium loss due to thiazide diuretics and otherconditions. The Swiss Pharmacy, Geneva Switzerland

2. Aldactone Spironolactone TabletsChemical Structure The Swiss Pharmacy, Geneva Switzerland 3. Aldactone Spironolactone TabletsActive IngredientThe active pharmaceuticalingredient present in AldactoneTablets is Spironolactone. The Swiss Pharmacy, Geneva Switzerland 4. Aldactone Spironolactone TabletsIndicationsAldactone Tablets, is used for the treatment of:1. Essential hypertension (high blood pressure withan unknown cause)2. Oedematous disorders (swelling with fluid),including congestive cardiac failure3.Diagnosis and treatment of primary aldosteronism(a hormone disorder causing fluid retention)4.Add-on therapy in malignant hypertension5.Reducing or preventing potassium loss due tothiazide diuretics6.Prevention of low amounts of potassium in theblood in patients taking digitalis (a type of heartmedicine) The Swiss Pharmacy, Geneva Switzerland 5. Aldactone Spironolactone TabletsIndications7. Long-term maintenance therapy for patients withbilateral micro or macronodular adrenalhyperplasia8. Edematous conditions for patients with Congestiveheart failure: For the management of edema andsodium retention when the patient is only partiallyresponsive to, or is intolerant of, other therapeuticmeasures.9.Cirrhosis of the liver accompanied by edemaand/or ascites The Swiss Pharmacy, Geneva Switzerland 6. Aldactone Spironolactone TabletsIndications10.Nephrotic syndrome: For nephrotic patients whentreatment of the underlying disease,restriction of fluid and sodium intake, and the use ofother diuretics do not provide an adequate response.11.Hypokalemia: For the treatment of patients withhypokalemia when other measures are consideredinappropriate or inadequate.12.Severe heart failure (NYHA class III IV)To increase survival, and to reduce the need forhospitalization for heart failure when used in additionto standard therapy. The Swiss Pharmacy, Geneva Switzerland 7. Aldactone Spironolactone TabletsIndications13.Long-term maintenance therapy for patients withdiscrete aldosterone-producing adrenaladenomas who are judged to be poor operative risksor who decline surgery.14. Treatment of hirsutism The Swiss Pharmacy, Geneva Switzerland 8. Aldactone Spironolactone TabletsRecommended Adult DosageDiagnosis of Primary Hyperaldosteronism:Long test: Aldactone is administered at adaily dosage of 400 mg for three to fourweeks.Short test: Aldactone is administered at adaily dosage of 400 mg for four days. The Swiss Pharmacy, Geneva Switzerland 9. Aldactone Spironolactone TabletsRecommended Adult DosageEdema in adults (congestive heartfailure, hepatic cirrhosis, or nephroticsyndrome):An initial daily dosage of 100 mg ofAldactone administered in either single ordivided doses is recommended, but mayrange from 25 to 200 mg daily. Whengiven as the sole agent for diuresis,Aldactone should be continued for at leastfive days at the initial dosage level, afterwhich it may be adjusted to the optimaltherapeutic or maintenance level. The Swiss Pharmacy, Geneva Switzerland 10. Aldactone Spironolactone TabletsRecommended Adult DosageEssential Hypertension.For adults, an initial daily dosage of 50 to 100mg of Aldactone administered in either single ordivided doses is recommended.Hypokalemia:Aldactone in a dosage ranging from 25 mg to100 mg daily is useful in treating a diuretic-inducedhypokalemia, when oral potassiumsupplements or other potassium-sparingregimens are considered inappropriate. The Swiss Pharmacy, Geneva Switzerland 11. Aldactone Spironolactone TabletsRecommended Adult DosageSevere Heart Failure (NYHA class III IV):Treatment should be started with Aldactone 25mg once daily if the patients serum potassium is=5.0 mEq/L and the patients serum creatinine is= 2.5 mg/dL. Patients who tolerate 25 mg oncedaily may have their dosage increased to 50 mgonce daily as clinically indicated. Patients whodo not tolerate 25 mg once daily may have theirdosage reduced to 25 mg every other day. The Swiss Pharmacy, Geneva Switzerland 12. Aldactone Spironolactone TabletsContraindicationsAldactone Tablets (Spironolactone) iscontraindicated in patients with thefollowing conditions:Hypersensitivity to Spironolactone or anyinactive component of this medication.Contraindicated for patients with anuria,acute renal insufficiency, significantimpairment of renal excretory function, orhyperkalemia. The Swiss Pharmacy, Geneva Switzerland 13. Aldactone Spironolactone TabletsSide Effects of Aldactone TabletsTell your doctor if you notice any of thefollowing and they worry you:Cramping or diarrhoea, nausea orvomiting, drowsiness, lethargy or generallyfeeling unwell, skin rash or itchiness, fever,unusual hair loss or thinning andexcessive hair growth. The Swiss Pharmacy, Geneva Switzerland 14. Aldactone Spironolactone TabletsSide Effects of Aldactone TabletsTell your doctor as soon as possible in case younotice any of the following:Frequent infection such as fever, severe chills,sore throat or mouth ulcers. A few cases ofagranulocytosis (lack of white blood cells) havebeen reported in patients taking AldactoneTablets.Breast enlargement. Breast enlargement mayoccur in men taking Aldactone Tablets. Thisnormally goes away when Aldactone Tablets arestopped. In rare instances some breastenlargement may persist. The Swiss Pharmacy, Geneva Switzerland 15. Aldactone Spironolactone TabletsSide Effects of Aldactone TabletsBreast Lumps: Breast lumps and breast cancerhave been reported in patients taking AldactoneTablets although Aldactone has not beenshown to cause breast cancer.If any of the following side effects occur, stoptaking Aldactone and either inform your doctorimmediately or go to Accident and Emergency atyour nearest hospital:Stomach bleeding, ulcers or gastritis(inflammation of the stomach), unsteadinesswhen walking, leg cramps, headache, mentalconfusion or dizziness. The Swiss Pharmacy, Geneva Switzerland 16. Aldactone Spironolactone TabletsSide Effects of Aldactone TabletsChange in sex drive, impotence (inabilityto achieve or maintain an erection), breastpain, irregular periods or no periods, post-menopausalbleeding. shortness of breathand swelling of the legs from fluid build(may be due to hyperkalaemia that is veryserious)These are very serious side effects. Youmay need urgent medical attention orhospitalisation. The Swiss Pharmacy, Geneva Switzerland 17. Aldactone Spironolactone TabletsWarnings And PrecautionsPotassium supplementation, either in the form ofmedication or as a diet rich in potassium, should notordinarily be given in association with Aldactonetherapy.Hyperkalemia in patients with severe heart failure.Hyperkalemia may be fatal. It is critical to monitor andmanage serum potassium in patients with severeheart failure receiving Aldactone ..Aldactone should be used with caution in patientswith impaired hepatic function. The Swiss Pharmacy, Geneva Switzerland 18. Aldactone Spironolactone TabletsOverdose SymptomsThe symptoms of acute overdosage ofAldactone are drowsiness, mental confusion,maculopapular or erythematous rash, nausea,vomiting, dizziness, or diarrhea.Rarely, instances of hyponatremia,hyperkalemia, or hepatic coma may occur inpatients with severe liver disease, but these areunlikely due to acute overdosage.Hyperkalemia may occur, especially in patientswith impaired renal function. The Swiss Pharmacy, Geneva Switzerland 19. Aldactone Spironolactone TabletsOverdose TreatmentIn the event of Aldactone overdose,Induce vomiting or evacuate thestomach by lavage. There is nospecific antidote. Treatment issupportive to maintain hydration,electrolyte balance, and vitalfunctions. The Swiss Pharmacy, Geneva Switzerland 20. Aldactone Spironolactone TabletsAldactone Tablets manufactured byRPG Life Science Ltd., India.For more information click here The Swiss Pharmacy, Geneva Switzerland