Alexandra Richardson, PhD, CLPApril 2015

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Clayton Biotechnologies, Inc. is a for-profit company which facilitates the commercialization of medical discoveries made by the Clayton Foundation for Research and its supporting entities.

The two-fold mission of the Foundation is to:► conduct medical research for the purpose of discovering the cause,

prevention and cure of diseases for the benefit of mankind, and► transfer the resulting medical research discoveries from the laboratory to

the use of the general public by patenting and licensing such technology for development into drugs or other products.

The Clayton Foundation for Research is a nonprofit medical research organization in Houston, Texas established in 1933 by Benjamin Clayton.

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Medical Research at Leading Research Institutions

Salk

UCSD

UT-Austin UT-Southwestern

UT-Medical Branch

MD Anderson

Baylor College of MedicineUTHSC-San Antonio

North Carolina State

U. of Geneva

Medical research for the purpose of discovering the cause, prevention and cure of diseases for the benefit of mankind

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Medical Research to Develop Cures

Cancer

Immunotoxins for targeted cancer therapy

Avicin to treat Mantle cell Lymphoma

Monoclonal antibodies targeting angiogenesis

Engineered proteases

Next generation anti-mitotic drugs

Fc engineered aglycosylated antibodies

CNS & Ophthalmology

Stem Cell Therapy for Parkinson’s Disease

Modulation of brain stress in neurological diseases

Genetic disease models for neurological diseases

Gene therapy and peptide therapeutics for AMD

Metabolic Diseases

Urocortin peptides for diabetes

GLP-1 combination therapy

Molecular switches in glucose control

Serum oxysterols as biomarkers of disease

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Medical Research to Develop Cures

Infectious Diseases

Vaccines for Dengue and Chinkungunya

Vaccines and diagnostics for Ehrlichioses

Autoimmune & Inflammation

Engineered proteases

Fc engineering of aglycosylated antibodies

Cardiology

Urocortin peptides and gene therapy for

congestive heart failure

OCT-TPL diagnostics of human vascular plaques

Endometriosis

Small molecules targeting SRC

OCT Image Guided Laser knife for diagnosis and

treatment

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Examples

Leaders in Innovation and Technology

Stem CellTherapy

GeneTherapy

Protein Engineering, Antibodies andImmunotoxins

Neuropeptides

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Mission Two:To transfer the resulting medical research discoveries from the laboratory to the use of the general public by patenting and licensing such technology for development into drugs or other products.• Collaborations• Spin-out companies• Licensing

Transforming Research Into Products

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Portfolio of Start-up Companies

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Some of Our Other Licensees

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Marketed Products•bupivacaine liposome injectable suspension•PainExparel•Morphine liposome injectable suspension•Post-operative painDepoDur•Cytarabine liposomes injectable suspension•Lymphomatous and solid tumor meningitisDepocyt•Cardiac PET Imaging•Medical imaging systems for private practicesAttrius •Neonatal and pediatric imaging system•Wide-field digital imaging system for the hospital and clinicRetcam•Ehrlichoisis canine•Assay for canine vector borne diseasesAccuPlex 4•Ataxia diagnostic•Assay for Spinocerebellar ataxia type 6 (SCA6)

SCA6 Diagnostic tests

•Functional Intracellular analysis•Assay for intracellular function of essential micronutrientsFIA

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Clinical Pipeline

Lenti-D Childhood ALD Pre-clinical Phase I Phase II/III

LentiGlobin

Beta-thalassemia Pre-clinical Phase I/II

LentiGlobin

Sickle cell anemia Pre-clinical Phase I

Retinostat AMD Pre-clinical Phase I

Urocortin Congestive Heart Failure Pre-clinical Phase I Phase II

VC-01 Type I Diabetes Pre-clinical Phase I

a-TEA Breast cancer Pre-clinical Phase I

IndicationCandidatecompound Development Stage Partner

Available to Partner

A Cancer Research Hospital

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Advanced Pre-clinical Pipeline IndicationCandidate

compound Development Stage Partner

EncorstatCorneal

graft rejection

Pre-clinical IND

Avicin Mantle Cell Lymphoma Pre-clinical IND

Dengue tetra

vaccine

Dengue Fever IND package

VEGF-rGel Solid Tumors IND package

VEGF-rGel AMD Advanced pre-clinical

Available to Partner

Available to Partner

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• Urocortins and analogues for Diabetes• GLP-1 agonist combination therapies for Diabetes

• Alk4-Fc, a Cripto antagonist for Cancer• Granzyme B - a potent payload for antibody drug conjugates (ADC)• YESS - engineering of proteases• Fc engineered antibodies with specific effector function

• Filaggrin to treat dermatological disorders• TEAD gene and peptide therapies for ocular neovascular disease• CRFR1 antagonists - therapeutic for early onset AD• Stem cell therapy program for Parkinson's Disease• Vaccines and Diagnostics for Ehrlichioses• OCT guided laser knife for surgery in small spaces

Collaboration and Licensing Opportunities

One Riverway, Suite 1520Houston, Texas 77056

713.963.5860www.claytonbiotech.com

arichardson@claytonbiotech.com

Conducting and funding research

Transferring research into products