alternative models of the body: opening science to cross-cultural dialogue

84
Alternate Models of the Body: Opening Science to Cross-Cultural Dialogue Alternate Models of the Body: Opening Science to Cross-Cultural Dialogue Neil Theise, MD Departments of Pathology and Medicine (Digestive Diseases) Mount Sinai Beth Israel Medical Center New York City Icahn School of Medicine at Mount Sinai

Upload: neil-theise

Post on 12-Jan-2017

75 views

Category:

Health & Medicine


0 download

TRANSCRIPT

Page 1: Alternative models of the body: Opening science to cross-cultural dialogue

Alternate Models of the Body: Opening Science to Cross-Cultural Dialogue

Alternate Models of the Body: Opening Science to Cross-Cultural Dialogue

Neil Theise, MDDepartments of Pathology and Medicine (Digestive Diseases)Mount Sinai Beth Israel Medical CenterNew York City

Icahn School of Medicine at Mount Sinai

Page 2: Alternative models of the body: Opening science to cross-cultural dialogue

neiltheise.com

neiltheise.wordpress.com

Page 3: Alternative models of the body: Opening science to cross-cultural dialogue

Beyond Cell Doctrine Complexity Theory Informs Alternate Models of the Body for Cross-Cultural Dialogue

Theise ND.Ann N Y Acad Sci. 2009; 1172: 263-9.

Page 4: Alternative models of the body: Opening science to cross-cultural dialogue

Mechanisms of Yogic Practices in Health, Aging, and DiseaseKuntsevich V, Bushcell WC, Theise ND. Mount Sinai J Med. 2010; 77: 559–569.

From the global to the local: possible pathways for the transduction of Indo-Sino-Tibetan cognitive-behavioral practices into site-specific, tissue-regenerative effects.

Bushell WC, Spector NH, Theise ND.Ann N Y Acad Sci. 2009; 1172: 74-87

Toward a unified field of study: longevity, regeneration, and protection of health through meditation and related practices.

Bushell WC, Theise ND.Ann N Y Acad Sci. 2009; 1172: 5-19

Page 5: Alternative models of the body: Opening science to cross-cultural dialogue

neiltheise.com

neiltheise.wordpress.com

also: Researchgate, Academia.edu

Page 6: Alternative models of the body: Opening science to cross-cultural dialogue

Cross Cultural Views of Bodies

A Complexity Primer

The Universe as Complex System

Biofields and Boundaries

Page 7: Alternative models of the body: Opening science to cross-cultural dialogue

Cross Cultural Views of Bodies

A Complexity Primer

The Universe as Complex System

Biofields and Boundaries

Page 8: Alternative models of the body: Opening science to cross-cultural dialogue

Cross Cultural Views of Bodies “Western” Biology and Medicine

Page 9: Alternative models of the body: Opening science to cross-cultural dialogue

Cross Cultural Views of Bodies “Western” Biology and Medicine

= “Cell Doctrine”

Page 10: Alternative models of the body: Opening science to cross-cultural dialogue

Cross Cultural Views of Bodies “Western” Biology and Medicine

= “Cell Doctrine” Non-”Western” traditions

Page 11: Alternative models of the body: Opening science to cross-cultural dialogue

Cross Cultural Views of Bodies “Western” Biology and Medicine

= “Cell Doctrine” Non-”Western” traditions

…”nested” bodies

Page 12: Alternative models of the body: Opening science to cross-cultural dialogue

Cross Cultural Views of Bodies

A Complexity Primer

The Universe as Complex System

Biofields and Boundaries

Page 13: Alternative models of the body: Opening science to cross-cultural dialogue

Complex Adaptive Systems:

1Lewin R, Complexity: Life at the Edge of Chaos. 2nd ed. Chicago IL: University of Chicago Press; 2002.

2Johnson S, Emergence. New York NY: Scribner; 2001.

1,2

Page 14: Alternative models of the body: Opening science to cross-cultural dialogue

Complex Adaptive Systems:Interacting individuals that,

if they fulfill 4 criteria,organize themselves from the bottom up,

into larger structures, which appear planned from the top, downward…

Page 15: Alternative models of the body: Opening science to cross-cultural dialogue

Complex Adaptive Systems:Interacting individuals that,

if they fulfill 4 criteria,organize themselves from the bottom up,

into larger structures, which appear planned from the top, downward…

Page 16: Alternative models of the body: Opening science to cross-cultural dialogue

Complex Adaptive Systems:Interacting individuals that,

if they fulfill 4 criteria,organize themselves from the bottom up,

into larger structures, which appear planned from the top, downward…

BUT ARE NOT!

Page 17: Alternative models of the body: Opening science to cross-cultural dialogue

Complex Adaptive Systems:Interacting individuals that,

if they fulfill 4 criteria,organize themselves from the bottom up,

into larger structures, which appear planned from the top, downward…

These structures are referred to as“emergent self-organization”

and are ADAPTIVE.

Page 18: Alternative models of the body: Opening science to cross-cultural dialogue

Complex Adaptive Systems:• Numbers matter

Page 19: Alternative models of the body: Opening science to cross-cultural dialogue

Complex Adaptive Systems:• Numbers matter

• Negative feedback loops

Page 20: Alternative models of the body: Opening science to cross-cultural dialogue

Complex Adaptive Systems:• Numbers matter

• Negative feedback loops

• Interactions are local without global sensing

Page 21: Alternative models of the body: Opening science to cross-cultural dialogue

Complex Adaptive Systems:• Numbers matter

• Negative feedback loops

• Interactions are local without global sensing

• Low level randomness

Page 22: Alternative models of the body: Opening science to cross-cultural dialogue

Complex Adaptive Systems:• Numbers matter

• Negative feedback loops

• Interactions are local without global sensing

• “Quenched disorder”

Page 23: Alternative models of the body: Opening science to cross-cultural dialogue
Page 24: Alternative models of the body: Opening science to cross-cultural dialogue
Page 25: Alternative models of the body: Opening science to cross-cultural dialogue

1Theise ND. Exp Hematology 20032D’Inverno M, Theise ND. BCMD 20043D’Inverno M, Theise ND, Prophet J.

In: Potten C, Wilson J, Clarke R, Renahan A: Tissue stem cells: Biology and applications

Page 26: Alternative models of the body: Opening science to cross-cultural dialogue

Implications of Cell Lineagesas Complex Adaptive Systems

Mass extinctions.

Page 27: Alternative models of the body: Opening science to cross-cultural dialogue

order

disorder“chaos”

Page 28: Alternative models of the body: Opening science to cross-cultural dialogue

disorder“chaos”

complex adaptive

systemsorder

Page 29: Alternative models of the body: Opening science to cross-cultural dialogue

Implications

The price of adaptation,

i.e. of LIFE,

is DEATH

Page 30: Alternative models of the body: Opening science to cross-cultural dialogue

Cross Cultural Views of Bodies

A Complexity Primer

The Universe as Complex System

Biofields and Boundaries

Page 31: Alternative models of the body: Opening science to cross-cultural dialogue

Hierarchies of complex systems…

Theise. Nature, May 2006

Page 32: Alternative models of the body: Opening science to cross-cultural dialogue
Page 33: Alternative models of the body: Opening science to cross-cultural dialogue
Page 34: Alternative models of the body: Opening science to cross-cultural dialogue
Page 35: Alternative models of the body: Opening science to cross-cultural dialogue

Hierarchies of complex systems…

thing vs. phenomena

depends on scale of observation

Page 36: Alternative models of the body: Opening science to cross-cultural dialogue
Page 37: Alternative models of the body: Opening science to cross-cultural dialogue

ChRISTOPHER SWANN

Page 38: Alternative models of the body: Opening science to cross-cultural dialogue

Hierarchies of complex systems…

thing vs. phenomena

depends on scale of observation

Page 39: Alternative models of the body: Opening science to cross-cultural dialogue

Hierarchies of complex systems…

thing vs. phenomena

depends on scale of observation

=> COMPLEMENTARITY

Theise. Nature, May 2006Theise & Kafatos, Complexity, 2013

Page 40: Alternative models of the body: Opening science to cross-cultural dialogue
Page 41: Alternative models of the body: Opening science to cross-cultural dialogue

Complementarity and the Copenhagen InterpretationQuantum phenomena exhibit complementary aspects that are revealed by specific observations, i.e. there are a range of possible states prior to observation and any single observation is unable to capture all aspects of the complete physical situation simultaneously.

Page 42: Alternative models of the body: Opening science to cross-cultural dialogue

Complementarity and the Copenhagen InterpretationQuantum phenomena exhibit complementary aspects that are revealed by specific observations, i.e. there are a range of possible states prior to observation and any single observation is unable to capture all aspects of the complete physical situation simultaneously.

Biological Complementarity

Page 43: Alternative models of the body: Opening science to cross-cultural dialogue

CommunitiesBodiesCells

Page 44: Alternative models of the body: Opening science to cross-cultural dialogue

e.g. cities, cultures, ecosystems, GaiaBodiesCells

Page 45: Alternative models of the body: Opening science to cross-cultural dialogue

CommunitiesBodiesCells

Page 46: Alternative models of the body: Opening science to cross-cultural dialogue

CommunitiesBodiesCells

Biomolecules

Page 47: Alternative models of the body: Opening science to cross-cultural dialogue

Theise ND. Now you see it, now you don’t.Nature, May 2005

“Cell doctrine: modern biology and medicine see the cell as the fundamental building block of livingorganisms, but this concept breaks down at different perspectives and scales.”

CommunitiesBodiesCells

Biomolecules

Page 48: Alternative models of the body: Opening science to cross-cultural dialogue

“The validity of cell doctrine depends on the scale at which the body is observed…

CommunitiesBodiesCells

Biomolecules

Page 49: Alternative models of the body: Opening science to cross-cultural dialogue

“The validity of cell doctrine depends on the scale at which the body is observed. To limit ourselves to the perspective of this model may mean that explications of some bodily phenomena remain outside the capacity of modern biology…

CommunitiesBodiesCells

Biomolecules

Page 50: Alternative models of the body: Opening science to cross-cultural dialogue

“The validity of cell doctrine depends on the scale at which the body is observed. To limit ourselves to the perspective of this model may mean that explications of some bodily phenomena remain outside the capacity of modern biology…

e.g. Acupuncture

CommunitiesBodiesCells

Biomolecules

Page 51: Alternative models of the body: Opening science to cross-cultural dialogue

What kind of models?

Page 52: Alternative models of the body: Opening science to cross-cultural dialogue

for example,2 models from Ancient Greece:

Is the body made of… indivisible subunits or an endlessly divisible fluid

Page 53: Alternative models of the body: Opening science to cross-cultural dialogue
Page 54: Alternative models of the body: Opening science to cross-cultural dialogue
Page 55: Alternative models of the body: Opening science to cross-cultural dialogue
Page 56: Alternative models of the body: Opening science to cross-cultural dialogue
Page 57: Alternative models of the body: Opening science to cross-cultural dialogue

Models of the body are perspective/technique dependent

Look at it this way (cell membranes): the body is made of cells

Look at it that way (organelles): the body is an endlessly divisible fluid

Page 58: Alternative models of the body: Opening science to cross-cultural dialogue

“The validity of cell doctrine depends on the scale at which the body is observed. To limit ourselves to the perspective of this model may mean that explications of some bodily phenomena remain outside the capacity of modern biology. It is perhaps time to dethrone the doctrine of the cell, to allow alternative models of the body for study and exploitation...”

CommunitiesBodiesCells

Biomolecules

Page 59: Alternative models of the body: Opening science to cross-cultural dialogue

Theise. Nature, May 2006Theise & Kafatos, Complexity, 2013

Biological Complementarity

Page 60: Alternative models of the body: Opening science to cross-cultural dialogue

NOT A HIERARCHY…

Page 61: Alternative models of the body: Opening science to cross-cultural dialogue

NOT A HIERARCHY… A HOLARCHY!

Page 62: Alternative models of the body: Opening science to cross-cultural dialogue

CommunitiesBodiesCells

BiomoleculesAtoms

Page 63: Alternative models of the body: Opening science to cross-cultural dialogue

CommunitiesBodiesCells

BiomoleculesAtoms

Page 65: Alternative models of the body: Opening science to cross-cultural dialogue

CommunitiesBodiesCells

BiomoleculesAtoms

We are walking, talking Earth…

Page 66: Alternative models of the body: Opening science to cross-cultural dialogue

CommunitiesBodiesCells

BiomoleculesAtoms

Subatomic Particles

Page 67: Alternative models of the body: Opening science to cross-cultural dialogue

CommunitiesBodiesCells

BiomoleculesAtoms

Subatomic ParticlesStrings (or whatever)

Page 68: Alternative models of the body: Opening science to cross-cultural dialogue

CommunitiesBodiesCells

BiomoleculesAtoms

Subatomic ParticlesStrings (or whatever)

The Quantum Foam

Page 69: Alternative models of the body: Opening science to cross-cultural dialogue

We don’t live in the universe . . .

Page 70: Alternative models of the body: Opening science to cross-cultural dialogue

. . . we are the universe

Page 71: Alternative models of the body: Opening science to cross-cultural dialogue

Cross Cultural Views of the Body

A Complexity Primer

The Universe as Complex System

Biofields and Boundaries

Page 72: Alternative models of the body: Opening science to cross-cultural dialogue
Page 73: Alternative models of the body: Opening science to cross-cultural dialogue

Boundaries are scale dependent

Theise. Nature, May 2006Theise & Kafatos, Complexity, 2013

Page 74: Alternative models of the body: Opening science to cross-cultural dialogue

disorder“chaos”

order

Page 75: Alternative models of the body: Opening science to cross-cultural dialogue

Macroscopic body

Microscopic body

Nanoscopic body

Quantum body

Page 76: Alternative models of the body: Opening science to cross-cultural dialogue

Macroscopic body

Microscopic body

Nanoscopic body

Quantum body

e.g. physical therapysurgery

e.g. stem cell therapies,probiotics, fecal txp

e.g. molecular medicineantibiotics

e.g. electromagnetics

Page 77: Alternative models of the body: Opening science to cross-cultural dialogue

Macroscopic body

Microscopic body

Nanoscopic body

Quantum body

e.g. yogatai chi

e.g. acupuncture?

e.g. traditional remedies

e.g. “energy” healing?meditation?

Nested Bodies, e.g. coarse, subtle, energy,

etc.

Page 78: Alternative models of the body: Opening science to cross-cultural dialogue
Page 79: Alternative models of the body: Opening science to cross-cultural dialogue
Page 80: Alternative models of the body: Opening science to cross-cultural dialogue
Page 81: Alternative models of the body: Opening science to cross-cultural dialogue
Page 82: Alternative models of the body: Opening science to cross-cultural dialogue
Page 83: Alternative models of the body: Opening science to cross-cultural dialogue

Fundamental Awareness:A framework for integrating science, philosophy and metaphysics

Neil D. Theise, MD Menas Kafatos, PhD

Communicative and Integrative Biology 2016; 3: e115010

Page 84: Alternative models of the body: Opening science to cross-cultural dialogue