alzheimer's, parkinson's, als, ms,
TRANSCRIPT
Alzheimer's, Parkinson's’ ALS,
MS, Fibromyalgia &
Neurodegenerative Disease –
Common Pathologies &
Prevention
By: Morwenna Given
Medical Herbalist
BA MA (Oxon) BSC BHG
m.OHA AHG RH
24th January 2012 1
WHO AM I?
I am a medical herbalist, trained in University, Hospital and clinics in the UK
With a practise in downtown Toronto focussing on:
Chronic auto immune diseases including MS, Cancer, Alzheimer's, diabetes, thyroid and Women's’ issues
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WHAT DO I DO?
A person who treats medical disease
‘wholistically’ on an evidence based basis
with whole plant extracts
A person who treats the cause of the problem
not just the symptom
We are specialists in the use of medicinal
plants and their ability to resolve disease
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WHAT IS: NEURO
DEGENERATIVE DISEASE?
These are diseases with the more familiar names such as MS & Alzheimer's
They have been placed in this category of medical disease as they are diagnosed and measured by change in the brain and nerves.
Each specific disease has its own characteristics for diagnosis such as amyloid plaques in Alzheimers
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The search for causes
determined by drug patentability
Genetic in Origin? Front Biosci (Elite Ed). 2013 Jan 1;5:167-77.Genetics of familial and sporadic
Alzheimer's disease.Piaceri I, Nacmias B, Sorbi S.
Failure of current treatments Biochem Pharmacol. 2012 Nov 22. pii: S0006-2952(12)00755-1. doi:
10.1016/j.bcp.2012.11.014. Alzheimer's Therapeutics: Continued clinical
failures question the validity of the amyloid hypothesis - but what lies beyond?
Mullane K, Williams M.
Amyloid hypthesis
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Common causes
All these disorders have much in common.
Aetiology is surprising uniform Brain Nerve. 2012
Jun;64(6):675-9.
Are neurodegenerative diseases "protein
cancers"?.Hasegawa M.Dept. of Neuropathology and Cell Biology,
Tokyo Metropolitan Institute of Medical Science
Appoptosin is a novel pro-apoptotic protein
and mediates cell death in neurodegeneration.
Zhang H et alJ Neurosci. 2012 Oct 31;32(44):15565-76. doi:
10.1523/JNEUROSCI.3668-12.2012
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Viral and Bacterial
Implications
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.
Berer K, et al Nature. 2011 Oct 26;479(7374):538-41. doi: 10.1038/nature10554. PMID: 22031325
Intrathecal antibody production against Chlamydia pneumoniae in multiple sclerosis is part of a polyspecific immune response. Derfuss T, et al. Brain. 2001 Jul;124(Pt 7):1325-35. PMID: 11408328
Intracerebral propagation of Alzheimer's disease: Strengthening evidence of a herpes simplex virus etiology.Ball MJ,et al.Alzheimers Dement. 2012 Nov 14. doi:pii: S1552-5260(12)02420-X. 10.1016/j.jalz.2012.07.005. PMID: 23159044
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MORE COMMON FACTORS
More women than men Am J Public Health. 2013 Jan 17. Trends in Mortality Risk by Education Level and Cause of Death
Among US White Women From 1986 to 2006. Montez JK, Zajacova A.
Depression Neurochem Int. 2013 Jan 7. pii: S0197-0186(12)00412-3. doi:
10.1016/j.neuint.2012.12.014.Effect of diet on serotonergic neurotransmission in depression. Shabbir F,et al.
Poor diet Toxicol Lett. 2013 Jan 4. pii: S0378-4274(12)01461-0. doi:
10.1016/j.toxlet.2012.12.023. Acrolein induces Alzheimer's disease-like pathologies in vitro and in vivo.Huang et al.
LIFESTYLE Infection, inflammation, and chronic diseases: consequences of a modern lifestyle.
Ehlers S, 99(th) Dahlem Conference. Trends Immunol. 2010 May;31(5):184-90.
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Even More Common
Factors
Affects an older population
Previously confined to the Western World
Now increasing at rapid rates in the BRICK
Countries
Involves dysregulation of the HPA axis
Involves prolonged inflammation
Mechanisms of neurodegeneration shared between multiple sclerosis and Alzheimer's disease.
Lassmann H. J Neural Transm. 2011 May;118(5):747-52. doi: 10.1007/s00702-011-0607-8. Epub 2011 Mar 5. Review. PMID: 21373761
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RECAP
In the past @ 75yrs we have changed:
No exercise – the car
Diet – proliferation of processed foods high in
sugars and bacteria DT on line bacteria in chicken 23/01/13
Heavy use of antibiotics
High stress and culture of not being ill
But our bodies have not changed but we now
live @ 25yrs more than 50 yrs ago
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THE MICROBIOME
PROJECT
The microbiome is the most exciting
development in science in the last 50 yrs.
What you eat is totally under your control and
preventable medicine
There will never be a drug for bacteria as they
mutate like viruses
Most plants have anti bacterial and anti viral
properties!
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MICROBIOME
Auto immunity diseases arise from the gut Kirsten Berer & Krishnamorthy Max Planck Institute Freiburg
Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease. Ochoa-Repáraz J,et al Ann Neurol. 2011 Feb;69(2):240-7. doi: 10.1002/ana.22344. Review.
Gut bacterias trigger the reaction that causes the body’s immune system to misbehave – which is why amyloid deposits in the brain are a late stage feature…….Parkinson's develops years before signs and symptoms lead to a diagnosis
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Bacterial Actions
The inappropriate bacteria in the gut release
Lipases and other chemicals which in turn
Release proinflammatory and cytotoxic compounds which then attack the bodies’ own cells creating anti bodies which invade the immune system.
These chemicals then get circulated via neural and plasma networks to the brain where the damage can be visible eg protein clumps of amyloid.
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PREVENTION
It starts at birth with:
Exercise
Appropriate diet. You are what you eat.
Stress avoidance
Mental exercise
Laughter and happiness
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EXERCISE
"It is clear from this study and others that physical performance in late life plays an incredibly important role in our cognitive health," said Dr. Erickson. "Although more research is needed into the causal mechanisms and pathways by which this works, it is clear that physical performance in late life is critical for retaining a healthy brain."
Arch Neurol. Published online October 22, 2012. Exercise May Beat Mental Activity in Preserving Cognition. Medscape. Oct 24, 2012.
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MORE……
research has shown that exercise programs among patients with
neurologic disorders "increase the patients' sense of self-efficacy, their
sense of involvement in their care and overall belief in their abilities to
perform certain activities."
“… patient involvement leads to higher satisfaction with care, and
greater likelihood of following provider recommendations,". "In
essence, exercise puts the patient — not a pill — at the center of care,
which is exactly where patients want and ought to be."
Arch. Neurologist Nov 5th 2012
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STRESS: Mitochondrial defects and
oxidative stress in Alzheimer
disease and Parkinson disease.
Free Radic Biol Med. 2012 Nov 29. pii: S0891-
5849(12)01823-0. doi:
10.1016/j.freeradbiomed.2012.11.014.
Yan MH, Wang X, Zhu X.
Personal observation: MS starts with a combined
viral infection and emotional distress involving 5
http receptors ©
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DIET
Gluten intolerance may be a factor
Hybridised grains and overconsumption
Poor nutrition – lack of key vitamins, minerals in immunocompromised patients directly relates to poor function
Inflammation mediated memory dysfunction and effects of a ketogenic diet
High glucose levels affect the HPA Kim do et al Plos One 2012 7(5) 35476
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More…..
Human nutrition, the gut microbiome and the immune system.
Kau AL, et al;Nature. 2011 Jun 15;474(7351):327-36. doi: 10.1038/nature10213. Review. PMID: 21677749
Traditional Chinese medicine: balancing the gut ecosystem.
Li H,et al Phytother Res. 2009 Sep;23(9):1332-5. doi: 10.1002/ptr.2590.PMID: 19253310
Homocysteine induces apoptosis of rat hippocampal neurons by inhibiting 14-3-3ε expression and activating calcineurin.
PLoS One. 2012;7(11):e48247. Doi. 10.1371/journal.pone.0048247. Wang et al
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More….
Overprocessed foods and foods not fit for
human consumption
Two thirds of all raw shop bought chicken in
the UK is contaminated by campylobacter www.telegraph.co.uk/foodand drink/foodanddrinknews/9820838/FSA
Gloopy type margarine has diacetyl which has
been shown to promote beta amyloid which is
the hallmark of Alzheimers. More SS et ak The butter
flavorant Diacetyl exacerbates Beta-Amyloid cytotoxicity Chem Res. In
Toxicology 25th June 2012
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SUGAR
Like all diseases of excess sugar plays a key role in destabilising the body’s normal mechanisms including brain function
Excess sugar is derived from an inappropriate diet i.e. one high in grains
Insulin resistance a hall mark of co morbidities e.g. PCOS
High circulating levels of glucose affect the brain
J.Physiol 2012 590:2485-2499 Gomez-Pinella
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More….
The Role of Glucose Transporters in Brain Disease: Diabetes and
Alzheimers Disease.Shah K, Desilva S, Abbruscato T. Int J Mol Sci. 2012 Oct
3;13(10):12629-55. doi: 10.3390/ijms131012629
Reccomended reading
J Yudkin: Pure White and Deadly Penguin 2012
reprint
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KEY:
MISSING INGREDIENTS
Our locally grown vegetables do not have
sufficient zinc, selenium
Most people do not eat enough fish- iodine
Most people eat too much processed flour based
food – inhibiting - bromine.
All of which is interesting considering that is now
recognised neurological diseases starts in the gut.
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MORE…..
Amelioration of Alzheimer's disease by
neuroprotective effect of sulforaphane in
animal model. Kim HV, et al Amyloid. 2012 Dec 19.
Eat your sprouts!!
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VITAMIN D
Ontario is well known for its lack of vitamin D in
the population – it is recognised to be endemic
Reduced vitamin D is associated with the
geographic incidence of neuromuscular disorders
Loss/Lack of vitamin D affects bones, muscles,
thyroid, liver etc.
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Drugs
Basically the drugs used for most neurodegenerative diseases do not prevent progression – merely delay at best
Extensive side effects
Affect the quality of life
VERY POOR EVIDENCE TO JUSTIFY USE
I RECOMMEND YOU READ BAD PHARMA by Ben Goldacre 4th Estate
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PLANTS
Protective effect of paeonol on neurotoxicity
induced by Abeta1-42 and underlying
mechanisms. Zhong SZ, et al. (Paeony)
St John’s Wort – Hypericum
Centella asiatica – Gota Cola
Macuna Puriens Uncaria/ Cats Claw
Brahmi –Panax ginseng - Kudzu Pueria Lobata
Plants with anti bacterial & anti viral properties
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More……
Turmeric
Curcuminoids in neurodegenerative diseases. Kim DS, et al Recent Pat CNS Drug Discov. 2012 Dec;7(3):184-204. PMID:
22742420
Gingko
Astragalas
Andrographis
And more and more but only when used at a
therapeutic dose and as compounds
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THEY WORK!
Reversible worsening of symptoms after taking Cat’s claw ( Clin.Neuropharmacol 2008)
A diversity of compounds isolated from herbal materials were reported to be effective on neurotoxic models of PD by modulating multiple key events or signaling pathways implicated in the pathogenesis of PD j.Ethnopharmacol 2012 feb 15
We use a combination of plants in a tincture to synergise and maximise effectiveness which is not possible in a conventional drug
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CAUTIONS
PLEASE NOTE: IT IS ADVISED, THAT ANY PLANTS
MENTIONED IN THIS TALK, ARE ONLY USED
UNDER PROFESSIONAL GUIDANCE.
BOTANICAL MEDICINE AS COMPOUNDED BY A
PROFESSIONAL IS NOT AVAILABLE OVER THE
RETAIL COUNTER.
It is not advisable to self treat
A professional: will recognise all the issues within
the body; Select herbs that will impact positively on
these issues without causing problems in order to
co exist with other medications
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REFERENCES
www. Pubmed, Science direct
I have a full list of references for those who
are interested – if you would like either to
email me or put your name down tonight I will
send them to you. It is several pages long!
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