AMAMAMERRE ICICAAA AAN SOS CIETY FOR BIOCHEMISTRY Y AANDND MOLOLEECECULULAR BIBIOLO OGGY

SEPTEMMBER 9, 220111

VOLUME 286

NUUMBER 36

JBC_090911_#36.indd 1 8/12/11 4:15 PM

NEW Roche X-tremeGENE DNA Transfection Reagents

� Efficiently transfect common and hard-to-transfect cells

� Generate biologically meaningful results using these low cytotoxic reagents

� Enjoy the reliable, easy-to-use protocols

Request your Free Sample Today!

www.x-tremegene.roche.com

Transfect with Confidence. Build on Experience.

For life science research only.Not for use in diagnostic procedures.

X-TREMEGENE is a trademark of Roche.

Roche Diagnostics GmbHSandhofer Straße 11668305 Mannheim, Germany

© 2011 Roche Diagnostics.All rights reserved.

69626

GEORGE & MARY THOMPSON PRINCIPAL RESEARCH FELLOWSYDNEY MEDICAL SCHOOLREFERENCE NO. 4066/1110

A bequest to Royal North Shore Hospital from the late George & Mary Thompson has allowed the establishment of a position for a Principal Research Fellow in basic cellular/molecular cardiovascular science.

Based at the Kolling Institute of Medical Research, this role presents a rare opportunity for you to develop an original research program with the support of a dedicated team of academics and clinicians within state-of-the-art research facilities. You will also draw on the research strengths and collaborative opportunities in cardiovascular research within the Royal North Shore Hospital and the Kolling Institute.

Visit sydney.edu.au/positions and search by the reference number for more information and to apply.

CLOSING DATE: 5 June 2011

2011 ASBMB Special Symposia Series

JULY 20–23, Richmond, VA

Student-Centered Education in

the Molecular Life Sciences II J. Ellis Bell, University of Richmond

University of Richmond

JULY 24–26, Guangzhou, China

Recent Advances in Pathogenic

Human Viruses

Kuan-Teh Jeang, National Institute of Allergy and Infectious Diseases, NIHDouglas Lowy, National Cancer Institute, NIH

Guangzhou Baiyun International Convention Center

SEPT 27–Oct 2, Pacifi c Grove, CA

13th International ATPase Conference

Na, K-ATPase and Related P-ATPase: Structure,

Biology, and Medicine

Kathleen J. Sweadner, Harvard Medical School and Massachusetts General Hospital

Asilomar Conference Grounds

OCT 6–9, Snowbird, UT

Cellular Traffi c of Lipids and Calcium

at Membrane Contact Sites

Joint meeting with the Biochemical SocietyTim Levine, University College London Institute of Opthalmology, LondonWill Prinz, National Institute of Diabetes and Digestive and Kidney Diseases, NIH

Snowbird Ski and Summer Resort

OCT 12-16, Snowbird, UT Chemical, Synthetic and Systems Biology: New Di-

rections of Biochemistry in the 21st Century

Arcady Mushegian, Stowers Institute for Medical ResearchAled Edwards, University of Toronto, Canada

Snowbird Ski and Summer Resort

OCT 27–30, Tahoe City, CA

Gene Regulation by Non-Coding RNAs

Richard Carthew, Northwestern UniversityJennifer A. Doudna, HHMI, University of California, Berkeley

Granlibakken Resort and Conference Center

ASBMB MEMBER REGISTRATION DISCOUNTS

Become an ASBMB member and

receive registration discounts to these and other ASBMB-

sponsored events.

Join now at www.asbmb.org/membership

www.asbmb.org/specialsymposia

Become an ASBMB Member to read all new P450 research online for FREE!asbmb.org/membership

P450 Classics

Are you performing P450 research?50 research

JBC wants to publish your next paper!

Help JBC continue its publishing excellencellence in the P450 field.

Journal of Biological ChemistryNew P450 Collections

P450 Today

Full tables of contents and ordering information available: jbc.org/collections/p450

Experience the history of P450 through original research going back to 1964

Includes Reviews, Classics, and Reflections

The latest in P450 Research spanning 2005 to 2008

Includes papers on Ferredoxins and NADPH-P450 reductase

Cyto

chro

me

P45

0yyyyyyyyCy

to PPPPPPllaalaalaaalaaaalllllllurnal

A

Agrawal, Nitin, 31532

Ahn, Sun-Young, 31522

Air, Gillian M., 31610

Akizawa, Toshifumi, 31598

Akopova, Irina, 31799

Alam, Shahabuddin, 31385

Ambrozkiewicz, Mateusz,31781

An, Songon, 31810

Ando, Osamu, 31409

Andre, Isabelle, 31714

Arita, Kyohei, 31864

Arnold, Georg J., 31707

Arrowsmith, Cheryl H.,31225

Asano, Masahide, 31337

Ashida, Hitoshi, 31194

Atlan, Daniele, 31136

Auld, Douglas S., 31232

Autry, Joseph M., 31697

B

Babu, Ellappan, 31830

Bahudhanapati, Harinath,31761

Bailey, Scott, 31896

Baker, Brian M., 31466

Balaji, KithiganahalliNarayanaswamy,31347

Barbe, Sophie, 31714

Bargo, Sharon, 31288

Batra, Vinod K., 31650

Bayer, K. Ulrich, 31272

Bayry, Jagadeesh, 31347

Beard, William A., 31650

Becherel, Olivier J., 31542

Bergsmann, Judith, 31565

Beyl, Stanislav, 31557

Bhat, Ratan, 31153

Biber, Bjorn, 31586

Birnbaumer, Lutz, 31799

Birrell, Geoff, 31542

Blackburn, Mandy E.,31821

Blagova, Elena V., 31512

Block, Linda, 31586

Bodoor, Khaldon, 31839

Bohn, Laura M., 31731

Borbulevych, Oleg, 31466

Brand, Martin D., 31361

Brew, Keith, 31761

Brewer, Gary, 31145

Bush, Kevin T., 31522

C

Callahan, Robert, 31288

Candela, Thomas, 31250

Cao, Hongzhi, 31610

Cao, Weiguo, 31282

Carrasco-Lopez, Cesar,31714

Castro, German R., 31714

Cavanaugh, Nisha A.,31650

Chan, Kwok-Chu, 31771

Chang, Iksoo, 31225

Chang, Luan-Yin, 31373

Chao, Wei, 31308

Che, Chi-Ming, 31684

Chen, Howard H., 31308

Chen, Linjie, 31199

Chen, Philip, 31542

Chen, Shu-Chuan, 31373

Chen, Xi, 31610

Chen, Yi-Chun, 31373

Chen, Yu, 31749

Cheng, Liansheng, 31676

Chilton, Annemarie S.,31789

Chiluiza, David, 31288

Cho, Hyun-Soo, 31225

Choe, Kwang-Min, 31225

Choi, Jeong-Yun, 31180

Chokhawala, Harshal A.,31610

Christensen, Quin H.,31447

Chruszcz, Maksymilian,31742

Chu, Haiyan, 31213

Chung, Wai-Hong, 31771

Cierpicki, Tomasz, 31742

Conaway, H. Herschel,31425

Conception, Erlinda, 31168

Coothankandaswamy,Veena, 31830

Copeland, William C.,31490

Coultrap, Steven J., 31272

Cronan, John E., 31447

Cummings, Richard D.,31610

D

Danesh, Shahab M., 31064

Daniotti, Jose L., 31437

Das, Mom, 31810

Demichelis, Vanina Torres,31437

Deng, Xiaoyan, 31199

Depil, Katrin, 31557

Derler, Isabella, 31565

Derse, David, 31092

Dey, Sharmistha, 31723

Ding, Min, 31799

Ding, Yanfeng, 31799

Dnyanmote, Ankur, 31522

Dominy, Brian N., 31282

Dorjbal, Batsukh, 31092

Dork, Thilo, 31542

Doublet, Patricia, 31136

Dube, Divya, 31723

E

Egeler, Emily L., 31328

Elangovan, Selvakumar,31830

Eoff, Robert L., 31180

Eraly, Satish A., 31522

F

Fadlalla, Mohammed,31168

Fahrner, Marc, 31565

Fazry, Shazrul, 31542

Feng, Yan, 31308

Fernandez, Julio M., 31072

Ferraro, Gino B., 31418

Ferrer, Pilar, 31714

Fischer, Gerhard, 31915

Folkmann, Lindsay M.,31180

Forshammar, Johan, 31586

Fothergill-Gilmore, LindaA., 31232

Fournier, Alyson E., 31418

Fredman, Gabrielle, 31532

Frischauf, Irene, 31565

Frohlich, Thomas, 31707

Fruchart-Gaillard, Carole,31661

Fujita-Sato, Saori, 31409

G

Gabrielson, Edward, 31457

Gallegos, Tom F., 31522

Ganapathy, Vadivel, 31830

Garcia-Manyes, Sergi,31072

Garenaux, Estelle, 31250

Gatei, Magtouf, 31542

Gerencser, Akos A., 31361

Ghorpade, DevramSampat, 31347

Gierasch, Lila M., 31821

Gilbert, Christophe, 31136

Gilquin, Bernard, 31661

Glazebrook, Jane, 31297

Gnanaprakasam, Jaya P.,31830

Gohar, Michel, 31250

Graham, Sarabeth, 31799

Greenberg, David A.,31168

Greene, Mark I., 31676

Grembecka, Jolanta, 31742

Groer, Chad E., 31731

Groschner, Klaus, 31565

Gruber, Hermann J., 31565

Gryczynski, Zygmunt,31799

Guengerich, F. Peter,31180

Guerardel, Yann, 31250

Gueven, Nuri, 31542

Gurav, Ashish, 31830

H

Ha, Hyunjung, 31123

Hackett, John C., 31480

Hadad, Christopher M.,31810

Haga, Yoshimi, 31320

Hagar, Jon A., 31447

Haltiwanger, Robert S.,31623

Han, Jiahuai, 31501

Handa, Noriko, 31598

Hansson, Elisabeth, 31586

Harada, Takushi, 31598

Hasegawa, Jun, 31864

Hayashi, Fumiaki, 31598

Hayes, Christopher S.,31105

Haystead, Timothy A.,31839

He, Yang, 31159

He, Zheng-Guo, 31159

Hedfalk, Kristina, 31915

Heidecker, Gisela, 31092

Henning, Petra, 31425

Hering, Steffen, 31557

Hermoso, Juan A., 31714

Herve, Mireille, 31512

Hesek, Dusan, 31466,31714

Hirabayashi, Masumi,31885

Hirabayashi, Takahiro,31885

Hirano, Keizo, 31885

Hirayama, Teruyoshi,31885

Ho, Kenneth, 31168

Hohaus, Annette, 31557

Hong, Jeong Hee, 31799

Horler, Richard S. P., 31512

Hoshino, Daisuke, 31598

Hu, Siyi, 31676

Hu, Yan, 31145

Hu, Yanzhong, 31397

Huang, Haishan, 31199

Huang, Yuanxia, 31159

Huber, Amanda K., 31168

I

Irimia, Daniel, 31532

Ishii, Kumiko, 31320

Isobe, Takashi, 31409

Isogai, Shin, 31864

Isono, Fujio, 31409

Ito, Shuichiro, 31409

J

Jacobson, Eric M., 31168

Jaeger, Alex M., 31731

Jakob, Burkhard, 31542

Jamshidi, Neema, 31522

Janssen, Brian D., 31105

Jin, Lihua, 31473

Jin, Shikan, 31473

Jung, Haiyoung, 31123

K

Kakuda, Shinako, 31623

Kalb, Reinhard, 31542

Kaneko, Ryosuke, 31885

Karlstrom, Helena, 31153

Karunakaran, Senthil,31830

Kasiviswanathan, Rajesh,31490

Katagiri, Fumiaki, 31297

Kaur, Punit, 31723

Kaveri, Srini V., 31347

Kawamura, Yoshimi, 31885

Kigawa, Takanori, 31598

Kijas, Amanda W., 31542

Kim, Eun-Jin, 31180

Kim, Hyeyon, 31225

Kim, Tae Whan, 31213

Kissner, Teri L., 31385

Kitazume, Shinobu, 31875

Kizuka, Yasuhiko, 31337,31875

Ko, Sunggeon, 31225

Komatsu, Masaaki, 31864

Komissarova, Natalia,31576

Koshiba, Seizo, 31598

Koshikawa, Naohiko,31598

Kouno, Tetsuya, 31337

Krause, Henry M., 31225

Krishnamoorthy, Sriram,31532

Krzewinski, Frederic, 31250

Kumar, Pawan, 31213

Kumar, Sandeep, 31810

Kumarasiri, Malika, 31466

Kundu, Pallob, 31064

Kunz, Lars, 31707

Kuznicki, Jacek, 31781

L

Lamb, Audrey L., 31789

Lasanajak, Yi, 31610

Lavin, Martin F., 31542

Lawrence, Scott A., 31480

Lazzaroni, Jean-Claude,31136

Lee, Hyun-Wook, 31282

Lee, Ji-Hoon, 31542

Lee, Mijoon, 31466, 31714

Lee, Weontae, 31225

Lemmon, Colleen R. M.,31457

Lengyel, Szabolcs, 31839

Lerenthal, Yaniv, 31542

Lerner, Ulf H., 31425

Lester, Henry A., 31241

Letellier, Guillaume, 31661

Leung, Yun-Chung, 31771

Levdikov, Vladimir M.,31512

Levet-Paulo, Melanie,31136

Li, Cheuk Wun, 31168

Li, Guo, 31199

Li, Xiaoxia, 31213

Li, Yan, 31308

Li, Yong, 31473

Liao, Baisong, 31145

The Journal of Biological Chemistry

AUTHOR INDEX

SEPTEMBER 9, 2011 • VOLUME 286 • NUMBER 36 JOURNAL OF BIOLOGICAL CHEMISTRY xiii

Lin, Jinshan, 31297

Lin, Shengchen, 31473

Lindholm, Catharina,31425

Liu, Corey W., 31328

Liu, Fuli, 31684

Liu, Jing, 31676

Liu, Wallace H., 31272

Liu, Yang, 31676

Llarrull, Leticia I., 31466

Lloyd, Patricia, 31092

Loiselle, David, 31839

Lok, Chun-Nam, 31684

Lontay, Beata, 31839

Lu, Jiawei, 31501

Lu, Rong, 31064

Lubkowska, Lucyna, 31576

Lundborg, Christopher,31586

Luther, Kelvin B., 31623

M

Ma, Rong, 31799

Mackey, Elisha D. W.,31241

Maeda, Tadao, 31749

Maes, Emmanuel, 31250

Magnaudeix, Amandine,31080

Maharjan, Anu S., 31576

Mal, Gorakh, 31723

Malarkannan,Subramaniam, 31213

Mann, Enrique, 31385

Manoharan, Ravi, 31123

Maqbool, Abbas, 31512

Marcon, Elodie, 31661

Marquer, Catherine, 31661

Martínez-Ripoll, Martín,31714

Martin, Martha V., 31180

Mayerhofer, Artur, 31707

McDonnell, Donald P.,31839

McNae, Iain W., 31232

Meneely, Kathleen M.,31789

Menez, Andre, 31661

Michels, Paul A. M., 31232

Miller, Tara N., 31904

Mishra, Biswajit, 31723

Misztal, Katarzyna, 31781

Mivechi, Nahid F., 31397

Miwa, Julie M., 31241

Mo, Monica L., 31522

Mobashery, Shahriar,31466, 31714

Moberg, Andreas, 31915

Moisan, Lionel, 31385

Mora, Silvia I., 31113

Moran, Richard G., 31480

Morgan, Hugh P., 31232

Morimoto, Daichi, 31864

Morishita, Kaoru, 31409

Morrison, Charlotte J.,31418

Mourier, Gilles, 31661

Muallem, Shmuel, 31799

Muik, Martin, 31565

Mulepati, Sabin, 31896

Murai, Marcelo J., 31742

Murphy, Angus S., 31297

Musier-Forsyth, Karin,31810

N

Nagalski, Andrzej, 31781

Nagano, Makoto, 31598

Nagashima, Kunio, 31092

Nakagawa, Naoki, 31337

Naslund, Jan, 31153

Navaneetham,Duraiswamy, 31904

Neutze, Richard, 31915

Nguyen, Le V., 31297

Nigam, Sanjay K., 31522

Nita-Lazar, Aleksandra,31623

Niu, Liwen, 31676

Nowicki, Matthew W.,31232

O

Oberg, Fredrik, 31915

Ohyama, Takao, 31409

Oka, Shogo, 31337

Okano, Kiichiro, 31749

O’Leary, Heather, 31272

Olucha, Jose, 31789

Oomori, Tamotsu,31638

O’Riordan, Mary X. D.,31447

Ortiz-Ramirez, Carlos,31113

Overall, Christopher M.,31418

P

Palczewski, Krzysztof,31749

Palsson, Bernhard Ø.,31522

Pamren, Annelie, 31153

Pan, Chen, 31194

Pantoja, Omar, 31113

Pathak, Krishan M. L.,31723

Paull, Tanya T., 31542

Pedersen, Anders, 31915

Pedersen, Lee G., 31650

Pence, Matthew G., 31180

Peng, Jeffrey, 31466

Perera, Lalith, 31650

Periyasamy-Thandavan,Sudharsan, 31830

Persson, Emma, 31425

Pettersson, Ulrika, 31425

Pietrini, Sean D., 31697

Piomelli, Daniele, 31532

Pirhayati, Amir, 31425

Pollheimer, Philipp, 31565

Popa, Ionel, 31072

Prasad, Puttur D., 31830

Q

Qi, Yiping, 31297

Quinlan, Casey L., 31361

R

Rahman, M. Azizur, 31638

Rajasekaran,Kamalakannan, 31213

Rakhit, Rishi, 31328

Ramachandran, Sabarish,31830

Rana, Nadia A., 31623

Rebek, Julius, Jr., 31385

Rebek, Mitra, 31385

Reddy, Gireesh, 31742

Rhoads, Robert E., 31288

Richards, Christopher I.,31241

Robia, Seth L., 31697

Rojas-Altuve, Alzoray,31714

Romanin, Christoph,31565

Rombouts, Yoann, 31250

Rong, Hui, 31473

Rorabaugh, Jacki M., 31272

Rubin, John E., 31697

Ruthel, Gordon, 31385

S

Safi, Rachid, 31839

Saikh, Kamal U., 31385

Samarakoon, Asanga,31213

Sampson, Heidi, 31225

Schindler, Detlev, 31542

Schmid, Cullen L., 31731

Schoenlein, Patricia V.,31830

Schoonmaker, Robert T.,31904

Schwarzinger, Clemens,31565

Seidman, Jason S., 31105

Seiki, Motoharu, 31598

Seong, Hyun-A, 31123

Serhan, Charles N., 31532

Servent, Denis, 31661

Sharma, Amit, 31924

Sharma, Ashwani, 31924

Sharma, Pradeep, 31723

Sharma, Sujata, 31723

Shen, Guodong, 31676

Shi, Qicun, 31466

Shi, Ying, 31199

Shih, Hsiu-Ming, 31373

Shih, Shin-Ru, 31373

Shirakawa, Masahiro,31864

Shirouzu, Mikako, 31598

Shuo, Takuya, 31598

Si, Rui, 31308

Sidhu, Sachdev S., 31761

Silva-Martin, Noella, 31714

Singh, Nagendra, 31830

Singh, Tej P., 31723

Sinha, Dipali, 31904

Sinha, Mau, 31723

Sjohamn, Jennie, 31915

Skrabanek, Luce, 31168

Smith, David F., 31610

Smock, Robert G., 31821

So, Byung Ran, 31810

So, Pui-Kin, 31771

Soheilian, Ferri, 31092

Song, Xuezheng, 31610

Sosnovik, David E., 31308

Sou, Yu-shin, 31864

Spinnler, Katrin, 31707

Srinivasan, Rahul, 31241

Stary-Weinzinger, Anna,31557

Stefan, Mihaela, 31168

Stefani, Enrico, 31064

Strittmatter, Stephen M.,31418

Su, Ya-Chi, 31904

Sun, Wenyu, 31749

Suzuki, Tadashi, 31320

Suzuki, Takuya, 31263

Svensson, Olle, 31425

Sweet, Douglas H., 31522

Sy, Lai-King, 31684

T

Takeuchi, Hideyuki, 31623

Tanabe, Soichi, 31263

Tanaka, Keiji, 31864

Taniguchi, Naoyuki, 31875

Tappert, Mary M., 31610

Taucher-Scholz, Gisela,31542

Teng, Maikun, 31676

Tenno, Takeshi, 31864

Terro, Faraj, 31080

Thakar, Monica S., 31213

Thangaraju, Muthusamy,31830

Thomas, David D., 31697

Thomas, Gavin H., 31512

Thordal-Christensen,Hans, 31297

Timin, Eugen, 31557

Tinguely, Mathew, 31213

Tiwari, Vinod K., 31610

Tjernberg, Lars O., 31153

Tochio, Hidehito, 31864

Tochio, Naoya, 31598

Tomer, Yaron, 31168

Tomizawa, Tadashi, 31598

Toro, Ligia, 31064

Toyoda, Shunsuke, 31885

Treberg, Jason R., 31361

Trejo, Jorge, 31113

Tsuda, Kenichi, 31297

Tuckermann, Jan, 31425

Tully, Ellen, 31457

Turner, Daniel A., 31810

U

Ulrich, Robert G., 31385

Unzai, Satoru, 31864

Urner, Lorenz M., 31328

V

Vianney, Anne, 31136

Vilcaes, Aldo A., 31437

W

Wakabayashi, Kenji,31409

Walkinshaw, Malcolm D.,31232

Walsh, Peter N., 31904

Waltes, Regina, 31542

Wandless, Thomas J.,31328

Wang, Dayong, 31852

Wang, E., 31308

Wang, Jian, 31180

Wang, Rui, 31473

Wang, Xia, 31297

Wang, Xue-Kun, 31501

Wang, Yan-Hai, 31501

Wang, Yanxia, 31799

Wang, Yi, 31159

Wang, Yi-Wei, 31373

Wanngren, Johanna,31153

Warren, H. Shaw, 31308

Watanabe, Satoru, 31598

Wei, Zhengzheng, 31839

Weitzel, Douglas H., 31839

Weng, Kuo-Feng, 31373

Wilkinson, Anthony J.,31512

Wilsbach, Kathleen, 31457

Wilson, Brian, 31466

Wilson, Cornelia M., 31080

Wilson, Samuel H., 31650

Winblad, Bengt, 31153

Winters, Ali, 31799

Winters, Deborah L., 31697

Wisniewska, Marta B.,31781

Wong, Kwok-Yin, 31771

Wong, Wai-Ting, 31771

Woo, Ju-Hyung, 31457

Worheide, Gert, 31638

Wu, Chun, 31199

Wu, Su-Qin, 31501

Wu, Wei, 31522

Wu, Xiao-Nan, 31501

X

Xiang, Yang K., 31852

Xiao, Cheng, 31241

Xiao, Yechen, 31213

Xu, Xiaojuan, 31194

Xue, Chaolun, 31159

Y

Yagi, Takeshi, 31885

Yan, Zhen, 31852

Yang, Rong, 31532

Yang, Shao-Hua, 31799

Yap, Hong-Kin, 31771

Yardin, Catherine, 31080

Yokota, Shinnichi, 31885

Yokoyama, Shigeyuki,31598

Yoo, Jiho, 31225

Yoshida, Minoru, 31875

Yoshihara, Toru, 31337

Yoshinaga, Naho, 31263

Yu, Hai, 31610

Yuen, Eunice Y., 31852

Yun, Ji-Hye, 31225

Z

Zha, Zhao, 31676

Zhang, Hongbing, 31501

Zhang, Hongtao, 31676

Zhang, Jiwang, 31213

Zhang, Lina, 31194

Zhang, Ming, 31308

Zhang, Ning, 31749

Zhang, Weilie, 31714

Zhang, Yingnan, 31761

Zhao, Yanxiang, 31771

Zheng, Haojie, 31610

Zheng, Min, 31501

Zheng, Songyang, 31473

Zhong, Wenhe, 31232

Zhou, Huamin, 31501

Zhou, Huihao, 31676

Zhou, Naiming, 31199

Zhou, Qi, 31199

Zhou, Yuan, 31852

Zhu, Juanjuan, 31676

Zhu, Qubo, 31749

Zinn-Justin, Sophie, 31661

Zou, Lin, 31308

xiv JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME 286 • NUMBER 36 • SEPTEMBER 9, 2011

See what the American Society for Biochemistry and Molecular Biology can do for you!

You’re a biochemist and you belong with us!

JOIN NOW! WWW.ASBMB.ORG

All ASBMB Members receive the following benefits:

DOING RESEARCH IN THESE FIELDS?