1 introduction

Introductory Biochemistry

Bioch 200

Course Outline and Objectives

Biochemistry 200Introductory Biochemistry

Section A3

TR 12:30-1:50 amTelus 150

Dr. Jonathan Parrish

Source: http://xkcd.com

How to contact your instructor

Dr. Jonathan Parrish

Department of Biochemistry

Room 5-79 MSB

jparrish@ualberta.ca

780-492-2866

Office Hours:

Wednesday 10:00am-12:00noon

Other ContactsDr. A. Wright

Biochemistry 200 Course Coordinator5-81A Medical Sciences Buildingawright@ualberta.ca; 492-8065

Ms. Shannon Swan Biochemistry Student Services

5-81 Medical Sciences Buildingshannon.swan@ualberta.ca; 492-5006

Prerequisites

CHEM 101: Introductory University Chemistry I

CHEM 164 or 261: Organic Chemistry I

Check your registration, contact Shannon Swan if you have concerns regarding your registration status.

The add/withdraw deadline for Winter term is September 21!

Course Content1. Introduction

2. Biomolecules

3. Nucleotides and Nucleic Acids

4. Protein Structure and Function

5. Enzymes

6. Biological Membranes

7. Introduction to Metabolism

8. Glucose Metabolism

BIOCH 200: Course Objectives

A one-term overview of the scope of biochemistry.

An introduction to the subject’s extensive terminology.

Emphasis on relevance to other fields (medicine, nutrition, athletic performance).

A foundation for further study in diverse subjects (medicine, pharmacy/pharmacology, kinesiology, nutrition, agriculture).

Who takes Bioch 200?

Who wants to take Bioch 200?

Support Materials Textbook “Essential Biochemistry”

by Charlotte W. Pratt & Kathleen Cornely

Practice Questions Recommended from the textbook Problem Sets

Posted on WebCT Exam Questions

Posted on WebCT

Learning Objectives Posted on WebCT and in PowerPoint lectures

iClickers

• These can be obtained at the Bookstore.• Other courses may also use them• There is a refund/return policy for the

iClickers

Answers will not be graded or assessed, but participation will be evaluated.

iClicker Assessment Answers will not be graded

Participation will be assessed 1% if participate 25-50% 3% if participate 51-75% 5% if participate >75%

Register your iclicker

http://www.iclicker.com/registration/ First Name:

Last Name: Student ID: User ID for eClassClicker ID:

Register by September 14th 2010 If you purchase your iClicker and it has already been registered please follow the

same directions as if it were new. If the barcode has faded please bring your iClicker to me after class or to

Shannon in Rm 5-81 MSB.

Brainspan Game System

https://maggie.srv.ualberta.ca/brainspan/

Practice Exam Questions

YOU MUST change your alias (Starts as userid)

Exam Schedule: BIOCH 200 Midterm I – October 7th

20%

Midterm II – November 10th

20%

Final Exam – December 22nd

55% (Cumulative) Consolidated exam

Check the University exam schedule when it is posted.

Introductory Biochemistry

eClasswww.ualberta.ca/ELEARNING/

www.ualberta.ca/helpCall the Help Desk at 492-9400

helpdesk@ualberta.ca

Regulations Pertaining to Deferred Examinations

Do not miss exams. Medical excuse required. See Dr. Wright for permission to write

deferred exams. All deferred midterm examinations will

occur on December 9th. Deferred exams are short answer, not

multiple choice.

How to do well in this course

Attend class. Review learning objectives and make sure

you can meet them all. Do the practice questions. Read the text and do the recommended

exercises.

Study!

http://www.youtube.com/watch?v=2ArIj236UHs

Fundamentals of Biochemistry

1. IntroductionWhat is Biochemistry?

What is Biochemistry?

The scientific discipline that seeks to explain life at the molecular level.

A means for determining how organisms “work” using the tools and terminology of chemistry.

A practical science with wide-ranging applications in a range of life science subjects, in treatment of diseases, and in industry.

Levels of Organization in Organisms

Fundamentals of Biochemistry

1. IntroductionBiomolecules

Elements in Biological Systems

Biomolecules

simple molecules H2O, CO2, NH3, O2, N2

building blocks amino acids, carbohydrates, nucleotides, lipids

polymers proteins, polysaccharides, nucleic acids

supra-molecular assemblies ribosomes, chromatin, membranes, etc.

organelles

cells

tissues, organs

The Four Major Classes of Biomolecule

amino acids

carbohydrates

nucleotides

lipids

Representing Biomolecules

Functional Groups and Linkages

Table 1.1

Table 1.1

Biopolymers

Biopolymers

Functions of Biopolymers

Biopolymer Encode Information

Metabolic Reactions

Store Energy

Cellular Structures

Proteins No Yes Somewhat Yes

Nucleic Acids Yes No No No

Polysaccharides Somewhat No Yes Yes

Introductory Biochemistry

1. IntroductionWater

Water

Water

Van der Waal’s Interactions

Bond Strength in Biological Molecules

The Electronegativity of Atoms

Groups That Can Make H Bonds

Solubility in Water: Hydrophilic Interactions

The Hydrophobic Effect

The Hydrophobic Effect

Amphiphilic molecules experience hydrophilic interactions and the hydrophobic effect.

Amphiphilic molecules experience hydrophilic interactions and the hydrophobic effect.