10 years on the road to awesome! - cleantech...
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2015 LanzaTech. All rights reserved.
12 Years On the Road to Awesome! 2016 LanzaTech. All rights reserved.
“The best way to predict the future is to invent it.”
Alan Kay
What I CAN predict
linear circular
Confidential
Innovation, Strong Will and Regulation!
1950s 2013
5 Business Confidential
Los Angeles
London
Cuyahoga River
New Delhi
Lima
1969 2016
4.3
Trillion tons lost 2003-2010
0.5inches
Added to global sea level
A Carbon Smart World
Gas Feed Stream
Gas Reception Compression Fermentation Recovery Product Tank
Recycling Carbon
Gas fermentation
technology converts C-
rich gases (CO, CO2) to
fuels and chemicals
Proprietary
Microbe
Performance milestones achieved and exceeded for >1000 hours at 0.3kMTA Potential Feedstocks
Recycling Carbon Around the World
Caofeidian, China
16M
gallons/year
Gent, Belgium
21M
gallons/year
From Mill to Wing
Ethanol
Chemical
Conversion Diesel
&
Jet Fuel
4,000 gallons of on-spec jet and 600 gallons of diesel produced Excellent analytical and Fit for Purpose results
Phase 1 Research Report Submitted $4M DOE Award to Build Demo
Recycle Make
CCU
“CCS”
Enables the Circular Economy
Building a Technology Platform
Gas Feed Stream
Gas Reception Compression Fermentation Recovery Product Tank
Hydrocarbon Fuels
Ethanol
Butanediol
Acrylonitrile Butadiene Styrene (ABS)
Nylon 6,6 (from Adiponitrile/HDMA)
Propanol Butanol
LanzaTech’s Integrated Multi-Scale Platform
Industrial proven
host strain
Intellectual Property >200 granted patents on all aspects of process
Efficient genetic toolbox
Scalable reactor designs
Process optimization and scale up
Integrated models and algorithms
Synthetic Biology to Improve Selectivity
Ethanol 2,3-BDO
Biomass
Acetate
Ethanol
Biomass Acetate
From Lab to Pilot in 1st Attempt!
Inokuma et al., 2010, Improvement of isopropanol production by metabolically engineered Escherichia coli using gas stripping. J Biosci Bioeng, 110: 696-701.
Bes
t N
ati
ve P
rod
uce
r: C
. bei
jeri
nck
ii • Native Promoter
• Genome Expression
• Batch fed
• Pure Glucose
• Minimal medium
Bes
t En
gin
eere
d s
tra
in:
E. c
oli • High-cost
promoter
• Plasmid expression
• Batch fed
• Pure Glucose
• Complex medium
C. a
uto
eth
an
og
enu
m
• Low cost promoter
• Plasmid expression
• Continuous
• Waste steel mill gas
• Minimal medium
<0.1 g/L/h Stable < 3 days
0.67 g/L/h Stable <10
days
>2.5 g/L/h Stable >3 weeks
Isopropanol Production
Synthetic Biology to Develop New Products
Fluctuations in price Predict 5-10 years down line
Disrupting Market Cycles
DISRUPTION = 1) Rapid Reaction to Market Fluctuations 2) Feedstock ≠ Commodity
Same reactor Same operating
conditions
Same feedstock
“hardware”
“software”
improved efficiency, tolerance, ethanol only
new product molecule
Microbe 1.0
Microbe 1.1
Microbe 2.0
Ethanol
1 Organism, over 20 Products…
Pyruvate
CO/CO2/H2
Acetyl-CoA
Fatty Acids,
Terpenoids
Aromatics
Ethanol
Succinate
Lactate
2,3-Butanediol
Biodiesel
3-Hydroxypropionate
Isopropanol
Acetone
3-Hydroxybutyrate
1,3-Butanediol
Joint development
Isobutene
1,3-Butadiene
2-Hydroxyisobutyrate
Branched-chain Amino Acids
Methyl Ethyl Ketone
2-Butanol
Acetoin
1,2-Propanediol
1-Propanol
Jet
Isoprene
Aromatics
Acetate
(R), (S), mixed isomers
(R), (S), mixed isomers
1-Butanol
Butyrate
(R,R), meso, mixed isomers
Valine, leucine, Isoleucine
(R), (S), mixed isomers
Benzoate (p-hydroxyl, 2-amino, dihydroxy),
salicylate
Farnesene
Mevalonate
FAEE, FABE
Citramalate
Long chain alcohols
Acetone
100% 1% Selectivity
Demonstrated over 30 new products directly from gas
PHB
Jump to the Next Curve
We are the Next Curve
Diffusion
Adapt and adopt from others
Continuous improvement
at scale
Crossing the Valley of Death
Technology Evolution
Ease
of
fun
din
g
Pilot and Demonstration
First Commercial
Applied R&D
Engineering Development
Discovery
Sustainable enterprise
“There is only one way to avoid criticism: do
nothing, say nothing, and be nothing.”
Aristotle (384 - 322 BC)
We all Need to be Superheros!
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