3protein information resource, georgetown university, … · 2013-11-12 · ‘manual curation of...

‘Manual curation of Drosophila

melanogaster in UniProtKB’

Elena Cibrián Uhalte1 and UniProt Consortium1,2,3

1EMBL-European Bioinformatics Institute, Cambridge, UK

2SIB Swiss Institute of Bioinformatics, Geneva, Switzerland

3Protein Information Resource, Georgetown University, Washington DC & University of Delaware, USA

Email: help@uniprot.org URL: www.uniprot.org

Funding

UniProt is funded by the European Molecular Biology Laboratory, National Institutes of Health, European Union, Swiss Federal Government, British Heart Foundation and National Science

Foundation.

Drosophila melanogaster in UniProtKB

Drosophila melanogaster manually curated entry

Drosophila melanogaster is a priority model organism for UniProt Knowledgebase

(UniProtKB) manual curation. The Drosophila protein annotation program

focuses on the manual curation of characterised Drosophila melanogaster proteins

with experimental data from the scientific literature. UniProtKB provides a complete

non-redundant proteome for Drosophila melanogaster based on the translation of

the Drosophila melanogaster completely sequenced genome, which currently

comprises 19,721 entries and which can be downloaded from the UniProt website.

All Drosophila melanogaster entries are cross-referenced with FlyBase with which

UniProtKB keeps close contact in order to ensure data consistency between both

databases. In addition to melanogaster, 11 other Drosophila species are currently

present in UniProtKB as complete proteome sets.

Database cross-references

Annotation of biological information

All Drosophila melanogaster

entries are cross-referenced

with FlyBase

Manually curated

FlyBase gene symbol

Synonyms captured

from literature

Current ORF symbol

Manual

Referenced

annotation

Function

References:

Protein sequence features

Drosophila melanogaster

complete proteome

Keywords and Gene Ontology annotation Drosophila complete

proteome available

on UniProt website

Gene Ontology (GO) terms are assigned

manually based on experimental data from

the literature and also added based on

automatic methods. In addition, GO terms

are imported from other GO consortium

members

Nucleotide sequence

Manual annotation protocol