a goat on bald mountain case 05-1829 thomas e. cecere north carolina state university presented at...

A Goat on Bald MountainCase 05-1829

Thomas E. CecereNorth Carolina State University

Presented at SEVPAC 2008 – Permission granted for use on

SEVPAC website only

Signalment/History Castrated male adult mixed-

breed goat

Complete shed in spring for past several years – hair regrows over the summer

Most recent episode – no hair regrowth

Progressive ptyalism starting in spring Presented at SEVPAC 2008 –

Permission granted for use on SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on

SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on

SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on

SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on

SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on

SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on

SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on

SEVPAC website only

Morphologic DiagnosisSalivary gland: Diffuse, severe lymphocytic and eosinophilic sialoadenitis with atrophy and interstitial fibrosis

Presented at SEVPAC 2008 – Permission granted for use on

SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on

SEVPAC website only

Thymoma associated diseases Dry mouth (Sjogren Syndrome), alopecia

areata, myesthenia gravis and others in humans

Sjogren Syndrome Keratoconjunctivitis sicca, xerostomia Immune-mediated destruction of lacrimal and

salivary gland Primary vs. secondary (rheumatoid arthritis, SLE,

polymyositis, scleroderma, thymoma)

Xerostomia vs. Ptyalism in this case?Presented at SEVPAC 2008 –

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Alopecia Areata Autoimmune skin disease

Non-scarring alopecia Lymphocytic targeting of anagen hair bulbs

Associated with thymoma in humans

Alopecia Universalis

Thymoma associated exfoliative dermatitis

Cats, rabbits Lymphocytic mural folliculitis

Rottenberg S et al. Thymoma-associated exfoliative dermatitis in cats. Vet Pathol. 2004 Jul;41(4):429-33.

Presented at SEVPAC 2008 – Permission granted for use on

SEVPAC website only

Acknowledgements Keith Linder Kristi Mozzachio NCSU Histology

Lab – Sandra Horton

Arnaud, Arun, Danielle, Crystal, Midori, Sally

Presented at SEVPAC 2008 – Permission granted for use on

SEVPAC website only

Questions?

Questions?Presented at SEVPAC 2008 –

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