accelerated approaches to innovation and entrepreneurship

Accelerated approaches to

innovation and entrepreneurship

in healthcare

Paul Thorning

Digital Health Enterprise Zone Seminar Series

12th May 2020

Aims of this presentation• To explore some dimensions of innovation, and specific

applications in a range of healthcare settings

• To convince you – if you are not convinced already – that it

is possible for anyone to become a successful start-up

healthcare entrepreneur

• To introduce you to our innovation and entrepreneurship

progammes at the University of Bradford

• To invite you to become ambassadors for this programme,

at home and overseas, to help develop and scout for

entrepreneurial talent

• To encourage you to have a go yourself at starting a new

business

• To outline support available (including of course, DHEZ)

Model 4 Ps of innovation (Source: Bessant & Tidd, 2013)

Accelerated health innovation

in challenging times

Necessity is the mother of invention

- Plato

Wuhan - 1,600 beds – 11 days

London - 5,000 beds – 9 days

Source: Wikimedia

Recombinant vesicular

stomatitis virus–Zaire Ebola

virus (rVSV-ZEBOV), also

known as Ebola Zaire

vaccine (Ervebo, Merck)

approved in record time…

…studies also pioneered

ring vaccination concept

and highlighted the

potential for herd

immunity

https://www.who.int/news-room/detail/23-12-

2016-final-trial-results-confirm-ebola-vaccine-

provides-high-protection-against-disease

Source : On a path to accelerate access to Ebola vaccines: The WHO's research and

development efforts during the 2014-2016 Ebola epidemic in West Africa.

Henao-Restrepo AM et al. Current Opinion in Virology, 01 Apr 2016, 17:138-144

It’s not just what you know…

Global Alliance for Vaccines and Immunisation

Radical health innovation

Drone-delivered

medical supplies The biggest

Big Data

A stem-cell

cure for

diabetes

A more

diverse

global

bio bank

A disruptive

approach

to cancer

researchA wristband

that can read

your mindAn ultrasound

in your pocket

Cancer-diagnosing

artificial intelligence

AI to

read every

science paper

Walmart-

ification of

healthcare

3-D digital

hearts

Rehab in

virtual reality

12 innovations that will

change health care and

medicine in the 2020s

Abstracted from Time

website 25th October 2019

https://www.nationalgeographic.com/maga

zine/2019/01/12-innovations-technology-

revolutionize-future-medicine/#/embark-

future-of-medicine-

mz3497_181008_01651.jpg

CRISPR – CAS（Clustered regularly interspaced short palindromic repeats)

Source: Drug Target Review

Proteus Digital Health

Microchip pill approved

by FDA in 2012

- Microscopic submarine for

drug delivery and repairs

- 4 mm length by 0.65 mm Φ

- Magnetic powered

- microTEC (Germany)

- Self-assembling Nano-rockets for

drug delivery, repair, regeneration

- Four times larger than an HIV virus

- Platinum nanoparticles as motors

and hydrogen peroxide as fuel

- Radboud University, Nijmegen

- ‘Nano-swimmers‘ pushing drug micro-beads

- 200-300nm head with a 1-2 micron tail

- Steered and propelled by magnetic fields.

- Harvard

It’s in the blood…

• Genetically engineered malaria parasites that are stunted through

precise gene deletions (genetically attenuated parasites - "GAP")

• Harmless (attenuated) version of the parasite interacts with the body.

in the same way as the infective version, but without possibility of

causing disease.

• GAP-vaccination induces immune responses that protect against

future malaria infection.

First-in-human evaluation of

genetically attenuated

Plasmodium falciparum sporozoites

administered by bite of Anopheles

mosquitoes to adult volunteers.

Vaccine, 2013

“The Flying Syringe”

Accelerated health innovation

in challenging settings

Indian Journal of Pharmacology (2012): Comparison of safety and

efficacy of papaya dressing with hydrogen peroxide solution on

wound bed preparation in patients with wound gape

• Free healthy pregnancy and child health text messages in Swahili for expectant and

new mothers – who register interest by texting “MTOTO”

• Messages linked to the stage of development of the child

• In total, 55 million free text messages have been sent to Tanzanians since the project

began in 2012

Addressing malnutrition in

Kasulu District, Tanzania

• Moderate malnutrition in under-5s ~29%

(rising to 89% in some villages in some months)

• Severe malnutrition ~4%.

• Acute setting (local hospital)

– Intravenous rehydration

– Blood transfusion

– F75 and F100 formula milk

– ReSoMal

• Community setting

– Education, Education, Education…

– Exclusive breastfeeding, and during pregnancy

– Good weaning practice

– Power food, balanced diet (spinach, peanuts etc)

– Alternatives to formula milk

A changing approach

• Initial focus on treatment of malnourished

children within mission hospital

A changing approach

• New focus on travelling to villages with the

nutrition theatre group….

Health innovation through

re-purposing

A combination of norepinephrine reuptake inhibitor and muscarinic blocker may

optimally modulate genioglossus muscle tone across sleep stages.

One-night randomized placebo-controlled double-blind crossover trial of a fixed dose

of a norepinephrine reuptake inhibitor atomoxetine and an antimuscarinic drug

oxybutynin (named ato–oxy), in 20 patients with mild to moderate sleep apnoea.

Ato–oxy dramatically improved sleep apnoea compared with placebo. As a

result of treatment, the Apnoea/Hypopnoea Index (AHI) decreased, with events per

hour reducing from 28.5 to 7.5, accompanied by an increase in oxygen saturation.

In a subset of patients with AHI ≥ 10, AHI was lowered by 74%, and all patients

exhibited ≥50% reduction of AHI with significant improvement in sleep quality.

Notably, atomoxetine or oxybutynin alone did not reduce AHI

Pharmacotherapy of Obstructive

Sleep Apnea: Is Salvation Just

Around a Corner?

American Journal of Respiratory and Critical Care

Medicine. Volume 199, Issue 10

Example: mSAS® advantage in inhaled medicines

Standard micronised Crystec mSAS® processed

68% of drugreaches thedeep lung

26% of drugreaches thedeep lung

Adverse Event Oxybutynin Tolterodine Darifenacin Solifenacin Trospium Fesoterodine

Dry mouth 29%-61% 23% 20.2%-35.3% 10.9%-27.6% 20.1% 19%-35%

Constipation 7%-13% 6% 14.8%-21.3% 5.4%-13.4% 9.6% 4%-6%

Urinary retention <5% No report No report 1.4% 1.2% 1%

Blurred vision 1%-8% 1% >1% 3.8%-4.8% >0.5% <1%

Drowsiness 2%-12% 3% 0.9%-2.1% 1%-2.1% 1.9% <1%

Source: Hesch, 2007

17% men and women with urge incontinence world-wide

60% seek treatment

27% receive treatment

59% unable to tolerate treatment

Source: Adapted from

Milsom et al, 2014 and

Gopal et al, 2008

Urge incontinence – a snapshot

Exposure modelling - extended release Tolterodine in man (EMs) vs. inhaled Tolterodine in rat (4 urges/interventions per day)Modelled from own data (single exposure) and Malhorta et al. (2011), Br J Clin Pharm. 72: 226

WakingPre-

lunchGetting home

SexWaking

Lunchmeeting

Key in the door

Sex

[Target]

4mg ER Clinical0.3mg/kg rat inhaled

Reduced side effects and a60% reduction in anticholinergic burden

A unique modality enabled by mSAS®

An on-demand regimen for urge incontinence

UK Sponsor

+

Chinese Provincial funding地方政府资金

Our open innovation model… 我们的开放式创新模式

Open

innovation

workshop

Ideas

思路+

Expertise

专门技术

Proof of

concept

projects

Collaboration

合作

New

Technology

New

Companies

Industry Academia

Academia Industry

Shared

Opportunity

机会共享

Health and

Pharmaceutical

Technology

Partners in economic growth

与经济增长引擎区合作

• Five-day workshops

– Briefing > Group speed dating > Ideation > Project Selection

• 10 workshops held to date, 25 projects, RMB 60m of funding

– Drug Delivery

– Biomedical Materials and Repair

– Medical Diagnostics

– Cancer Technologies

– Enhanced Cancer Therapeutics

– Metabolic Disease and Cancer Drug Delivery

– Connected Health for Healthy Ageing

– Point of Care Diagnostics

– Diagnostic systems

– Technologies for Wellness and Healthy Ageing

UK-China Healthtech Open Innovation

An international healthcare technology innovation network

国际化医疗技术创新网络

Interacting with elderly people through their TV screen

通过电视屏幕与老人进行交流

Maintaining organ viability for transplant for up to 3X longer

相对于当前的方法，此技术可延长待移植器官活性3倍的时间

“The result of these four week clinical

trials highlighted that back pain levels

are significantly reduced following

standardised care alongside the

intervention and use of the

LumbaCurve LC3 device.”

Accelerated Global Entrepreneurship

Development and Social enterprise

UK-China Open Innovation

Triple Crown Business SchoolBright Building

Digital Health Enterprise Zone

Prototyping accelerator A $200m spin-out

“The highest-ranking university in the north

was the University of Bradford, one in eight

(12.14%) of their students start their own

company or work in senior managerial

roles upon finishing their degree.”

This would be great…

…but this is also our goal!

我知道如果我失败了，我不会后悔；我也知道如果我没有尝试，我一定会后悔。

Bradford Accelerated Global Entrepreneurship Programme

WORKSHOP 1Meet and

agree to form enterprise

Enterprise Mentoring

Start-up and Innovator

EntrepreneurProgramme

WORKSHOP 2 Enterprise

boot camp &dragon’s den

12 Bradford (Home and International) and 12 Chinese students

1. UK-China

WORKSHOP 1Meet and

agree to form enterprise

Enterprise Mentoring

WORKSHOP 2 Enterprise

boot camp &dragon’s den

24 Bradford-based Home and International students

2. Bradford

Any

Pre-graduationPre-arrival, with

partner universities

Taster Sessions and BSc to MSc

Entrepreneur Programme

Post-graduation

Training, networking, access to funding, virtual incubation, enterprise centre support

3. Graduate

Accelerated Student Entrepreneurship Programme

Bradford Accelerated Global Entrepreneurship Programme

WORKSHOP 1Meet and

agree to form enterprise

Enterprise Mentoring

Start-up and Innovator

EntrepreneurProgramme

WORKSHOP 2 Enterprise

boot camp &dragon’s den

12 Bradford (Home and International) and 12 Chinese students

1. UK-China

WORKSHOP 1Meet and

agree to form enterprise

Enterprise Mentoring

WORKSHOP 2 Enterprise

boot camp &dragon’s den

24 Bradford-based Home and International students

2. Bradford

Any

Pre-graduationPre-arrival, with

partner universities

Taster Sessions and BSc to MSc

Entrepreneur Programme

Post-graduation

Training, networking, access to funding, virtual incubation, enterprise centre support

3. Graduate

From idea to funded enterprise in 4 months

Briefing and awareness

raisingSelection

WORKSHOP 1 Speed

networking and ideas

Enterprise support

WORKSHOP 2Business

planning and pitching

Dragon’s Den

Business and social

enterprise concepts

MentoringPreliminary

business plans

Seed funding and

Incubation

Networking events

24 students

Enterprise support company

Workshop Week 1

Workshop Week 2

Graduate (Start-up/Innovator) Entrepreneur Programme

Bradford Accelerated Global Entrepreneurship Programme

WORKSHOP 1Meet and

agree to form enterprise

Enterprise Mentoring

Start-up and Innovator

EntrepreneurProgramme

WORKSHOP 2 Enterprise

boot camp &dragon’s den

12 Bradford (Home and International) and 12 Chinese students

1. UK-China

WORKSHOP 1Meet and

agree to form enterprise

Enterprise Mentoring

WORKSHOP 2 Enterprise

boot camp &dragon’s den

24 Bradford-based Home and International students

2. Bradford

Any

Pre-graduationPre-arrival, with

partner universities

Taster Sessions and BSc to MSc

Entrepreneur Programme

Post-graduation

Training, networking, access to funding, virtual incubation, enterprise centre support

3. Graduate

UK Entrepreneur visa support

1. Start-up visa (2 years)2. Innovator visa (3 years)3. Settlement

Bradford is the first University to be authorised by the Home Office to endorse visas in all three categories

“a genuine and credible business idea”

NEWINNOVATIVE

VIABLESCALABLE

Graduate Entrepreneur (Tier 1/Start-up visa)programme design

ActionLearning

Supported Learning

Expert sessions

Requested meeting

Mentoring Coaching

University of Bradford ASEP

Coming soon…

University of Bradford ASEP

ACCELERATED

STAFF ENTREPRENEURSHIP

PROGRAMME

Coming soon…

Please let us know if you are interested

Thank you for your interest

The most dangerous risk of all – the risk of spending your life not doing what you want,

on the bet you can buy yourself the freedom to do it later.