actives company overview_incos2016_draft040516

Actives International, L.L.CHigh Quality Active Ingredients …by Design

+1.201.236.2828www.ActivesInternational.com

6G Pearl CourtAllendale, NJ 07401

Our MissionDevelop and market highly refined active ingredients for personal care applications utilizing natural sources and advanced technologies.

Our Method• Explore• Select• Enhance• Deliver

Frombiomass

To finalingredient

ViaPure® Natural ExtractsViaPure® means …. high purity

…. low use levels…. cost efficient performance

High potency means ….

High purity means….…. low odor & color…. high potency

Natural Products Chemistry

Diverse sources: plant, marine, microbial, fungal

Lead to diverse chemicals & unique activities

Selection

FractionationBioassay

Discovery Process

Harvesting

Sourcing

Processing

Sustainable Production

Custom fermentation specialists

Sustainable Processing

Thorough Testing ProtocolsEnsure Safety & Efficacy

Safety In vitro Proof of Principle

In vivoClaim Substantiation

Highly-purified, biologically active ingredients from natural sources

Solutions for Skincare Concerns

Skincare Concern: Skintone Brightening

Skincare Solutions

ViaFerm® White ShiitakeViaPure® AndrographisViaPure® Licorice White

Skincare Solution Skincare Benefits

ViaFerm® White Shiitake

123

Picture of Shiitake

Skincare Concern: Skintone Brightening

Skincare Solution Skincare Benefits

ViaPure® Andrographis

123

Picture of Andrographis

Skincare Concern: Skintone Brightening

Skincare Solution Skincare Benefit

ViaPure® Licorice White

123

Picture of Glabridin

Skincare Concern: Skintone Brightening

Skincare Concern: Photoprotection

Skincare Solutions

ViaPure® Citrus ViaPure® Coleus

Skincare Solution Skincare Benefit

ViaPure® Citrus

123

Picture of Citrus

Skincare Concern: Photoprotection

Skincare Solution Skincare Benefit

ViaPure® Coleus

123

Picture of Coleus

Skincare Concern: Photoprotection

Skincare Concern: Sensitive Skin

Skincare Solutions

ViaPure® BoswelliaViaPure® HopsViaPure® LicoriceViaPure® Poria

Skincare Solution Skincare Benefit

ViaPure® Boswellia

123

Picture of Boswellia

Skincare Concern: Sensitive Skin

Skincare Solution Skincare Benefit

ViaPure® Hops

123

Picture of Hops

Skincare Concern: Sensitive Skin

Skincare Solution Skincare Benefit

ViaPure® Licorice

123

Picture of Licorice

Skincare Concern: Sensitive Skin

Skincare Solution Skincare Benefit

ViaPure® Poria

123

Picture of Poria

Skincare Concern: Sensitive Skin

Skincare Solution Skincare Benefit

ViaPure® Coleus123

Skincare Concern: Cellulite

Skincare Concern: Oily, Troubled Skin

Skincare Solution Skincare Benefit

ViaPure® Sabal123

Skincare Solution Skincare Benefit

ViaPure® Andrographis 1

ViaPure® Hops 1ViaPure® Poria 1

Skincare Concern: Eye Area

Skincare Concern: Desquamation

Skincare Solution Skincare Benefit

ViaPure® Rice123

Skincare Concern: Mature Skin

Skincare Solutions

ViaPure® Anogeissus ViaPure® Boswellia ViaPure® Citrus

Skincare Solution Skincare Benefit

ViaPure® Anogeissus

123

Picture of Anogeissus

Skincare Concern: Mature Skin

Skincare Solution Skincare Benefit

ViaPure® Boswellia

123

Picture of Boswellia

Skincare Concern: Mature Skin

Skincare Solution Skincare Benefit

ViaPure® Citrus

123

Picture of Citrus

Skincare Concern: Mature Skin

Skincare Concern: Healthy Skin Barrier

Skincare Solutions

ViaPure® Boswellia ViaPure® Coleus

Skincare Solution Skincare Benefit

ViaPure® Boswellia

123

Picture of Boswellia

Skincare Concern: Healthy Skin Barrier

Skincare Solution Skincare Benefit

ViaPure® Coleus

123

Picture of Coleus

Skincare Concern: Healthy Skin Barrier

Skincare Concern: EcoCert Ingredients

Skincare Solutions

ViaPure® Poria ViaPure® Sabal

A Global CompanyHeadquarters New Jersey USA

AgentsAustraliaCanadaChinaFranceGermanyItalyMalaysiaTaiwanUSA

Who We Are• Private company, Founded in 1998

• Headquarters: New Jersey, USA

• President & CEO: Jon Anderson, PhD

Headquarters: Allendale, NJ

# Employees: 14 Office area: 5,000 sq ftWarehouse: 13,000 sq ft

Award-winning Customer Service

13,000 sq ft Warehouse

Order assembly area

Skidded warehouse

Tote storage

Two Cold Storage Rooms

Large room with forklift access for skidded products

Small room convenient for small pack sizes

Efficient Material Handling,In-bound & Out-bound

Two shipping bays

Tradeshow Presence20x30 booth• SCC-NY

10x10 pop-up• SCC-CA• SCC-SW

Tabletop• SCC-FL• SCC-TW

Prompt Sampling Procedures

Most sample requests are shipped within 24 hours

Benefits of Our Approach

• High-purity extraction Improves color, odor, activity

Our Core Competencies

• Natural products chemistry

• Skin biology

• Safety and clinical efficacy studies

What We Do• Expertise in cosmetic raw material development and sales

• Proprietary brands and broad product line

• US sales force and sub-agencies around the US, Europe and Asia

• Custom product development for key customers

• Plants – High purity extracts• Marine – Phytoplankton / microalgae• Biofermentation• Custom fermentation

Land, Sea, and Lab

Sources for Actives

Same info as slides 7

&9?

• Plants

• Marine organisms

• Fungi

• Micro-organisms

Advanced Technology Aids Discovery ofActives from Nature

Same info as slides 7

&12?

• Identify activity / biomass of interest

• Conduct bioassay-directed fractionation

• Purify to isolate active, resulting in bench-top prototype

• Safety studies

• Clinical efficacy substantiation

In-house Development of High Purity Actives

Same idea as slide 4

From biomass

To active ingredient

Raw Material Development

Benefits of Our Approach• Controllable production by fermentation

Eliminates supply issuesProvides alternative engineering

Sustainable, low-carbon footprint

• Key Products– Marine micro algae

• Capabilities– Bioproduction– Down stream process

• New Developments

Microalgae Production

ViaPure® Natural Extracts

ViaPure® means …. high purity

High purity means….…. low odor & color…. high potency

Developing Long Term Relationships

Open cooperation among our partner companies• Manufacturing• Bioassays • Scientific exchange

Leading to • New opportunities that benefit both parties

Partners: Synergistic Expertise• Contipro Biotech

– R&D, biofermentations, manufacturing

• Corum– R&D, biopeptides, manufacturing

• US Biologics– Bio-fermentations, manufacturing

• Monteloeder– Sourcing, industrial scale-up

• Actives International– Natural products, discovery, bioassay,

prototype development

• Alchem & Olive Lifesciences– Sourcing, purifications, industrial scale-

up

• CLR– R&D, natural products, manufacturing,

marketing

“more like a PARTNER than a Distributor”

• We represent companies whose expertise complements our own core competencies

• Our partners have diverse manufacturing & research capabilities, which creates a set of unique synergies

• We frequently collaborate on the development or improvement of our partners’ products

Natural extracts Fermentationproducts

US agent US agent

MicroAlgae In DevelopmentFermentation

Co-owner

Sales andCustomerSupport

Researchand

Development

US BioLogics

US agent

BENEFIT

ViaFermWhite Shiitake Skin-tone lightening

Age spots

RECOMMENDED FOR

Exclusive US RepresentativeEstee Lauder Companies

Specialized in the development of biologically active ingredients fromnatural sources, many of which meet EcoCert and NaTrue standards

US Agent

Specialists in research, development and productionof hyaluronic acid, hyaluronic acid derivatives, and fermentation-derived bioactive molecules

US Agent

Exclusive US Representative

Northeast andSelected Multinational Companies

Develops, manufactures, and markets innovative active ingredients for the cosmetic and personal care industry

US Agent

Key Personnel

• Jon Anderson, PhD

• Young Anderson, PhD

• Thushara Diyabalanage, PhD

• Isabelle Balle

• Priya Malhotra, Michelle Rappoport

• Mary Davis

• Rose Chiusano

President; R&D

R&D Biology

R&D Chemistry

Operations

Sales

Marketing

Finance

SummaryOur MissionDevelop and market highly refined active ingredients from natural sources, utilizing the most advanced technologies

Our Method• Develop prototype raw materials in-house• Transfer technology to partners with manufacturing expertise• Develop sustainability in sourcing and production

Our FocusSkin treatment, hair care and personal care markets

Skincare Concern: Skintone Brightening

Skincare Solutions

ViaFerm® White ShiitakeViaPure® AndrographisViaPure® Licorice White

ViaPure® Product LineRECOMMENDED FOR

ViaPure Boswellia

Anti-inflammation Barrier repair

Sensitive skinFirmness & elasticity

BENEFIT

Picture of Boswellia

ViaPure® Product LineRECOMMENDED FOR

ViaPure Citrus

Anti-inflammation Photo-protection

FirmnessWrinkles

BENEFIT

Picture of Citrus

ViaPure® Product LineRECOMMENDED FOR

ViaPure Coleus

Keratinocyte differentiationPhoto-protectionPhoto-repairLipolysis

Barrier repairHealthy skinDaily use productsCellulite

BENEFIT

Picture of Coleus

ViaPure® Product LineRECOMMENDED FOR

ViaPureHops Anti-inflammation Under-eye products

BENEFIT

Picture of Hops

ViaPure® Product LineRECOMMENDED FOR

ViaPureLicorice Anti-inflammation

Eye productsSensitive skinWrinkles

BENEFIT

Picture of Licorice

ViaPure® Product LineRECOMMENDED FOR

ViaPureLicorice White

Multiple melanogenic pathway interactions

Skin-tone lightening

BENEFIT

Picture of Licorice Root

ViaPure® Product LineRECOMMENDED FOR

ViaPurePoria Anti-inflammation Eye products

Sensitive skin

BENEFIT

Picture of Poria

ViaPure® Product LineRECOMMENDED FOR

ViaPureRice Exfoliation

Cell renewal

BENEFIT

Picture of Rice

Skincare Concern: Cellulite

Skincare Solution

ViaPure® Coleus

Picture of Cellulite

Skincare Concern: Eye Area

Skincare Solutions

ViaPure® Andrographis ViaPure® Hops ViaPure® Poria