april 1976 vol. nine no. two fluoride · martin luther universtgt robert winship memorial clinic...

April 1976 Vol. Nine No. Two

FLUORIDE

OFFICIAL QUARTERLY JOURNAL

OF

OFFICERS

President Vice President Second Vice President H. M. Sinclair, M. D., D. Sc.

Utah State University Laboratory of Human Nutrition Medical College Logan. Utah Oxon, England Patiala, India

Prof. G. W. Miller, Ph. D. Prof. S. S. Jolly, M.D.

Secretary G. L. Waldbott, M.D. Warren, Michiwn

Prof. G. Fraddi, M.D. Institute of Occupational Medicine

University of Palermo. Italy

Prof. G. Halbwachs, Ph. D. Institute of Botany Vienna, Austria

Prof. Dr. G. Rosonberger Veterinary University

Hannover, Germany

MUDr. G. Baluova CSc.

ADVISORY BOARD

J. V. Marhold, M. D., Ph. D. Research Institute for Organic Synthesis

Pardubice, CSSR

Prof. J. 6. Patrick, Ph. D. Mary Baldwin College Staunton. Virginia

Prof. F. Pinot, M.D. RMne, France

EDITORIAL BOARD

Prof. G. Neil Jenkins Research Institute for Hygiene The Dental School, Univ. of

Bratislava, Czechoslovakia Newcastle Upon Tyne, England

Dr. Ernest Bovay, Director Jerry Krechniak, Ph. D. Akademia Medyuna,

Liebefeld Bern, Switzerland Gdahsk, Poland

John R. McLaren, M.D.

Federal Agric. Research Station

J. Franke, M.D.

Treasurer P. E. Zanfagna, M.D.

Lawrence, Massachusetts

A. H. Siddiqui, M.D. Coon Rapids, Minnesota

Prof. Reni Truhaut, Ph. D. Facult; De Pharmacie Univenit i do Paris, France

Prof. A. W. Burgstahler, Ph. D. University of Kansas

Lawrence. Kansas

Prof. Frederick W. Oehme, D.V.S. Kansas State University Manhattan, Kansas

Prof. Albert Schatz, Ph. D. Temple University

Philadelphia, Pa.

Carlo Mangoni di S. Stefano, M. D. Martin Luther Universtgt Robert Winship Memorial Clinic Instituteof Human Physiology

Halle/Saale, DDR Emory University University of Naples, Italy Atlanta, Georgia

Prof. S. P. S. Teotia, M. D. Department of Human H. Hanhijawi, D. D. S.

Korpilahti, Finland Metabolism Medical College

University of Meerut, India. K.A.V.R. Krishnamachari, M.D. National Institute of Nutrition

Hyderabad, India

Vol. Nine No. Two April, 1976 Pages 71-122

FLUORIDE Quarterly Reports

Issued by THE INTERNATIONAL SOCIETY FOR FLUORIDE RESEARCH

Editor G. L. Waldbott, M. D.

Warren, Michigan

Co-Editors A. W. Burgstahlor, Ph. D.

Lawrence, Kansas J. A. Yiamwyiannit, Ph. D.

Monrovia, California

CONTENTS

ED IT0 R I A L The Skeletal Changes in Chronic Fluorosis . . . . . . . . . . . . . . . . . .

ORIGINAL ARTICLES Populational Variation of Fluoride Parameters in Wild Ungulates

from the Western United States - by E. Kay, P.C. Tourangeau, and C.C. Gordon, Missoula, Montana ....................

Skeletal Fluorosis: Roentgenological and Histopathological Study by S.P.S. Teotia, M. Teotia and N.P.S. Teotia, Meerut, India . .

Treatment of Endemic Fluorosis in Human Beings: An Experimental Study - by S.P.S. Teotia, M. Teotia, and R.K. Singh, Meerut, India .................................

SPECIAL ARTICLE Possible Effects of Fluoride on the Thyroid - by J.R. McLaren,

Atlanta, Georgia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ABSTRACTS

Dietary Fluoride Intake of Infants - by E. Wiatrowski, L. Kramer, D. Osis, and H. Spencer, Hines, Illinois.. . . . . . . . . . . . . . . . . .

The Role of Calcium and Fluoride in Osteoporosis in Rhesus Monkeys - by H.J. Griffiths, R.D. Hunt, R.E. Zirnmerman, H. Finberg and J. Cuttino, Boston, Massachusetts . . . . . . . . . . . . .

Long Term Results of Mass Mouth Rinsing with Sodium Fluoride Solution in the Republic of Cuba - by V. W. Kunzel, F. Soto, J. Maiwald and R.C. Borroto, Leipzig, DDR and Havana, Cuba

71

73

91

98

105

116

117

1 i a

Increased Caries-Incidence by Oral Inoculation of Cariogenic Bacteria in Rats after Dietary Fluoride - by W.B. Clark, S.N. Kreitzman, and T.H. Howell, Atlanta, Georgia . . . . . . . . . . . . .

Relationships of Human Plasma Fluoride and Bone Fluoride to Age - by F.M. Parkins, N. Tinanoff, M. Moutinho, M.B. Anstey and M.H. Waziri, Iowa City, Iowa.. .....................

120

121

Fluoride Toothpaste: A Cause of Acne-Like Eruptions - by M.A. Saunders, Jr., Virginia Beach, Virginia . . . . . . . . . . . . . . . . . . . 121

FLUORIDE is published quarterly by THE INTERNATIONAL SOCIETY FOR FLUORIDE RESEARCH, INC.,

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MANUSCRIPTS for publication should be submitted in English, double-spaced with generous margins References should be arranged according t o the order in which they are cited in the text, and written as follow: Author, title, journal, volume, pages a d year. Each paper mus& contain a summary of not more than 12 lines.

Contributors will receive copier of the h u e of FLUORIDE containing their paper, free of charge.

FLUORIDE is listed in Current Contents Agricultural Food and Veterinary Sciences

Ear l ie r it was suggested t h a t t he amount of d ie ta ry fluoride was directly re la ted t o ungulate density through overgrazing and t h e associ- a t e d ingestion of soil-contaminated forage. This may also explain a pro- portion of t h e observed geographic fluoride variation, since the m o s t crowded bighorn sheep had t h e g r e a t e s t concentrations of skeletal fluo- r ide (23 - 28). However, o the r parameters allied with aggregate fluoride composition and utilization of na tura l mineral licks, f o r example, should be investigated before a definitive conclusion is formulated.

Interspecific Variation: Fluoride concentrations in ungulates collected on the National Bison Range (Table 7) established a degree of species variability, bu t insufficient sample sizes precluded s t a t i s t i c a l evaluations. animals a r e young and t o disappear with age. observed in cervids f r o m the Sapphire Mountains (Table 8). species specific fluoride accumulations were not definable which, in a l l like- lihood, was due t o these ungulates' submaximal population densit ies o r t he i r parallel forage preferences (29, 43 - 45).

The specific differences appear t o be minimal when the An identifical tendency was

In these instances,

TABLE 7

ppm f luor ide P a r a m e t e r s of Ungulates from t h e National Bison Range

Species AgeClass N j z SD cv SEji EX!& --

Bighorn sheep 3.5 yea r s 4.5-5.5 6. 5-7. 5 8+

Mule dee r 1 .5 yea r s 2.5 3. 5 4.5 10 +

Whitetail dee r 1.5 yea r s 2.5 3. 5

Pronghorn an te lope 1 month 2 3 6 8

1 5 27

2 81 .5 7 132.4 4 139.8 2 186.5

1 124.0 3 183.0 3 187.7 2 375.0 1 456.0

3 136.0 2 130.0 5 247.4

1 5.0 1 14.0 1 29.0 1 53.0 1 81.0

12 104.1 3 154.0

3 . 5 4 5 yrs . 2 162.0 5.5-6.5 3 190.0 9.5-12.5 3 363.7

Rocky Mountain 4 yea r s 1 253.0 goa t 5. 5 1 212.4

6.5 1 277. 1 9 1 288.9

21.9 29.5 10.2 27.2

46.1 49.4 32. 5

2 1.8 43.8 85.7

29.9 43.9

7 .1 34.7

103.2

26.9 22.3

7.3 14.8

25.2 26.3

8.7

16 .0 33.7 34.6

28.8 28.5

4.3 18.3 28.4

15. 5 11.1

5. 1 19 .5

26.6 28. 5 23.0

12.6 31. 0 38.3

-

8.6 25. 3

5. 0 20. 0 59.6

-

19.0 8.4 3.7

10 .4

14.6 15.2

6.1

9.2 23.8 15 .5

-

8. 3 16. 5

3.1 10 .5 16 .4

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Volume 9 Number 2 A p r i l 1976