articulos de nutrientes y sfc
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7/30/2019 Articulos de Nutrientes y SFC
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Major depressive disorder: probiotics may be an adjuvant therapy.
Logan AC, Katzman M.
Source
Nutrition Research Consulting, 50 Yonkers Terrace, 8-J Yonkers, NY 10704,USA. aclnd@cfs-fm.org
Abstract
Major depressive disorder (MDD) is an extremely complex and
heterogeneous condition. Emerging research suggests that nutritional
influences on MDD are currently underestimated. MDD patients have been
shown to have elevated levels of pro-inflammatory cytokines, increased
oxidative stress, altered gastrointestinal (GI) function, and lowered
micronutrient and omega-3 fatty acid status. Small intestinal bacterial
overgrowth (SIBO) is likely contributing to the limited nutrient absorption in
MDD. Stress, a significant factor in MDD, is known to alter GI microflora,
lowering levels of lactobacilli and bifidobacterium. Research suggests that
bacteria in the GI tract can communicate with the central nervous system,
even in the absence of an immune response. Probiotics have the potential
to lower systemic inflammatory cytokines, decrease oxidative stress,
improve nutritional status, and correct SIBO. The effect of probiotics on
systemic inflammatory cytokines and oxidative stress may ultimately lead to
increased brain derived neurotrophic factor (BDNF). It is our contention that
probiotics may be an adjuvant to standard care in MDD.
PMID: 15617861 [PubMed - indexed for MEDLINE]
Comparison of oral nicotinamide adenine dinucleotide (NADH) versus
conventional therapy for chronic fatigue syndrome.
Santaella ML, Font I, Disdier OM.
Source
Department of Medicine, University of Puerto Rico School of Medicine,
Medical Sciences Campus, San Juan, Puerto Rico.
Abstract
OBJECTIVE:
To compare effectiveness of oral therapy with reduced nicotinamide
adenine dinucleotide (NADH) to conventional modalities of treatment in
patients with chronic fatigue syndrome (CFS).
BACKGROUND:
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CFS is a potentially disabling condition of unknown etiology. Although its
clinical presentation is associated to a myriad of symptoms, fatigue is a
universal and essential finding for its diagnosis. No therapeutic regimen has
proven effective for this condition.
METHODS:
A total of 31 patients fulfilling the Centers for Disease Control criteria for
CFS, were randomly assigned to either NADH or nutritional supplements and
psychological therapy for 24 months. A thorough medical history, physical
examination and completion of a questionnaire on the severity of fatigue
and other symptoms were performed each trimester of therapy. In addition,
all of them underwent evaluation in terms of immunological parameters and
viral antibody titers. Statistical analysis was applied to the demographic
data, as well as to symptoms scores at baseline and at each trimester of
therapy.
RESULTS:
The twelve patients who received NADH had a dramatic and statistically
significant reduction of the mean symptom score in the first trimester (p
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