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Our Research Fellowship
and training opportunities
in human reproduction and
infertility represent one of the
most active and state-of-the-
art programs of its kind in the
United States.
Research Fellowshipin Reproductive Medicine
Center for Reproductive Medicine
Fellowship GoalsThe overall goal of our fellowship is to
train each person to become not only a
successful independent researcher but
also, through our unique mentorship
approach, become a superior professional.
GoalsAt the end of the fellowship term, candidateswill have:
1.Demonstratedaprofoundunderstandingofhuman infertility(maleand/orfemale) 2.Participatedinclinicalandbasicscienceresearch 3.Knowledgeofdesigningandexecutingnovel scientificresearch 4.Anunderstandingoftheessentialsofscientific writing,includingliteraturereviewandanalysis 5.Developedanunderstandingofbasicbiostatistics, includingskillsinpatientchartreview,data collection,dataentry,andorganization 6.Publishedresearchfindingsinpeer-reviewed scientificjournals 7.Developedsuperiorcommunicationskillspertaining toscientificpresentationanddiscussion 8.Knowledgetoobtainthenecessarycertification forconductingresearchonhumansubjects (IRB/HIPPA) 9.Learnedhowtowriteascientificresearchproposal forfunding
ResearchFellowship2|ClevelandClinicCenterforReproductiveMedicine
WonJunChoi,MD,PhD|2004–05Jinju,SouthKorea
TamerSaid,MD,PhD|2002–06Toronto,Canada
Testimonials from past Research Fellows:
“ I was extremely fortunate to work with renowned experts in the field of Reproductive Medicine from the United States, Germany, and the U.K. as a part of their collaboration with the Center for Reproductive Medicine. The innovative research that we produced remains a cornerstone in the areas of sperm sorting and sperm genomic integrity. I was able to publish more than thirty articles in high-impact Reproductive Medicine Journals as well as book chapters. In addition, I was provided with the opportunity to attend several international conferences during which I presented more than sixty oral and poster presentations.”
“I was impressed by the systematic environment in the laboratory. Although I was unfamiliar with bench research at first, I was soon able to focus on my project
without hesitation … The experiences in the lab gave me a strong belief that if I had an idea, I could make anything possible in that setting”
“My memories of the Cleveland Clinic are of being pushed to work harder and to never accept mediocre quality of work. This program teaches one to set high goals, and to
become better at everything one does.”
FabioPasqualotto,MD|1998-99CaxiasdoSul,Brazil
“I sincerely believe that the Center for Reproductive Medicine at the Cleveland Clinic helped me accomplish my short-term and long-term goals. I would highly
recommend this program for anyone who has a desire to learn and become successful in the world of academic medicine.”
DeepinderGoyal,MD|2006-2007UCLA,California
Testimonial from past Research Fellows:How to applyPleasesendthefollowinginformation:
• Up-to-dateCurriculumVitae
• 3recentlettersofrecommendationbyyour professors,chairman,orpersonsfirst-hand knowledgeofyourwork
• Acolorpassportpictureandacopyof thepassport
• Address,telephonenumber(mobile,home,and officeforpossiblepersonalinterview)
• Thedatewhenyoucanbeginthefellowship
• Thenames,datesandplacesofbirthofall familymemberswhowillaccompanyyou. Informusiftheyneedavisatoenterthe UnitedStates.(Foreignapplicantsonly)
Where to submitCRM@ccf.org
Click here for more information
ResearchFellowship3|ClevelandClinicCenterforReproductiveMedicine
Who can apply?Medicalgraduates,residents,physicians,
andscientistsinterestedinconducting
cutting-edgebasicscienceandclinical
researchinthefieldofReproductive
Medicinecanapplytoourprogram.
Applicantsareselectedonacompetitive
basisfromapoolofcandidatesfrom
aroundtheworld.Onceapproved,the
applicantisappointedasaResearch
FellowthroughtheClevelandClinic’s
GraduateMedicalEducationProgram.
Other Important Information• Candidatesshouldnotethatallappointments forresearchtrainingareforaminimumof1 yearandthereisnofinancialsupport.
• Candidatesmusthaveindependentfundsbefore beingconsideredforanappointment.Examples are:privateorgovernmentscholarshiptosupport livingexpensesintheUnitedStates.
• Researchappointmentsdonotresultinthe awardofadegree(MSc,PhD,orMD); successfulcompletionoftrainingresultsinthe awardofaCertificateofResearchTrainingfrom theCenterforReproductiveMedicine(CRM).
• Candidatesregisteredwiththeirparentinstitution foranadvanceddegree,suchasMaster’s,PhD, orMD,canselecttheClevelandClinicfortheir researchstudiesrequirements.Researchfindings, oncecompletedinourCenter,canbesubmitted towardsfulfillmentofadegreefromthe candidate’sowninstitutions.
• ResearchFellowsareencouragedtopublish theirfindingsinAmericanandEuropean peer-reviewedjournals.
Research & Training Methods1. Hands-ontraininginrelevantlaboratory techniques
2. Personalmentorship
3. On-siteandonlinecourses
4. Literaturereviewtools
Faculty
ShyamAllamaneni,MD|2003–04Buffalo,NewYork
“The program inculcates a great deal of ability to do hard work, punctuality, sincerity, art of communication with professionals, feeling of responsibility and aptitude to
work as team-member in fellows. The fellows will learn how to do multiple tasks simultaneously and efficiently”
Testimonials from past Research Fellows
“This program helped me interact with many experts in the field of ART from around the world. My stay at the Cleveland Clinic helped me to obtain the position of Scientific Director of a leading
corporate hospital’s IVF program back in India.”
AlexC.Varghese,PhD|2007–08Calcutta,India
ResearchFellowship4|ClevelandClinicCenterforReproductiveMedicine
Clickhereformoretestimonials
Ashok Agarwal, PhD, HCLDDirector,CenterforReproductiveMedicineProfessor,LernerCollegeofMedicine
Edmund Sabanegh, MDChairman,DepartmentofUrologyHead,SectionofMaleInfertility
Sajal Gupta, MDAsst.ResearchCoordinatorCenterforReproductiveMedicine
Jeffrey M. Goldberg, MDHead,SectionofReproductiveEndocrinologyandInfertilityOB-GYN&Women’sHealthInstitute
Rakesh Sharma, PhDResearchCoordinatorCenterforReproductiveMedicine
Tommaso Falcone, MDChairman,ClevelandClinicOB-GYN&Women’sHealthInstitute
Research OverviewMale InfertilityOneofthemajorgoalsofourCenteristobetterunderstandthecausesofmaleinfertilityandtodesignstudiesaimedatimprovingsemenquality.Wehopethislineofresearchwilleventuallyresultinstrategiesthatwillenableustousethehealthiestspermatozoaforfertilizationtoimprovethechancesofpregnancy.
Alongtheseobjectives,wearecurrentlyinvolvedinprojectsevaluatingoxidativestress-inducednuclearDNAdamageanditseffectsonspermqualityandpregnancyoutcome.StudiesdesignedtounderstandhowfreeradicalscauseDNAdamageandthepossiblemethodstocounteractthemarecurrentlybeingconducted.Wearealsocurrentlyevaluatingtheroleofnutritionalsupplementsinreducingoxidativestressininfertilemenandincreasingthenumberofsuccessfulpregnancies.Furthermore,theeffectsoflifestylechoicesonmaleinfertility,suchassmokingandcellphoneusage,arebeingevaluatedinlaboratorystudies.Tolearnmoreaboutourmaleinfertilityresearchclickhere.
Female InfertilityThefocusofourresearchintheareaoffemaleinfertilityistounderstandtheetiologyofendometriosis,bothsuperficialanddeep,andstudythemechanismsassociatedwithinfertility.Acurrentprojectexaminestheroleofoxidativestressandinfertilityassociatedwithendometriosis.Inaddition,newmodelsarebeinginvestigatedtodeveloptechniquestooptimizecryopreservationofovariesandstudytheirfertilizingpotential.Weareexaminingischemia-relatedfollicularlossutilizingmicrovascularanastomosisforlong-termsurvivalandfertilizingpotentialusingsheepasthestudymodel.Also,newinnovativemethodsfortissuere-engineeringandenrichmentoftheovariangraftsarecurrentlybeingpursuedtoimprovepost-transplantationovariangraftviabilityandfunctionality.
Anotherareaofinterestisthevitrificationofembryos,blastocysts,andisolatedblastomeresinconjunctionwithinvasiveandnoninvasivetechniquesoffreezing.TheeffectofblastocystvitrificationonDNAdamagearebeingexamined.Foradditionalinformationonourfemaleinfertilityresearchclickhere.
Research Collaborators & International FacultyTheCenterforReproductiveMedicinehascollaborativerelationshipswithmanyhighlyesteemedscientistsandcliniciansfromover14countries.Someoftherenownedcollaboratorsinclude:
Stefan du Plessis PhD, MBASouth Africa
Nabil AzizMB, ChB, FRCOG, MDUnited Kingdom
Rima DadaMD, PhDIndia
Sandro EstevesMD, PhDBrazil
Uwe PaaschMD, PhDGermany
Giancarlo Balercia MD Italy
Philip KumanovMD, PhD, DMSciBulgaria
Juan Alvarez MD, PhD Spain
Research InnovationsTolearnaboutallourresearchinnovationsinmaleandfemaleinfertilityclickhere.
Scientific PublicationsOur researchers and faculty have published numerous articles in reputedscientific journals, including over 500 peer-reviewed original articles andreviews,morethan100chaptersinspecializedmedicalbooks,andovertwodozentextbookspertainingtohumanreproductionandinfertility.Inaddition,wehavepresentedover750researchpapersatnationalandinternationalmeetings.OurfacultyaremembersofeditorialboardsofesteemedmedicaljournalssuchasFertility Sterility, Urology, and Obstetrics & Gynecology.Tolearnmoreandviewourpublicationsclickhere.
ResearchFellowship5|ClevelandClinicCenterforReproductiveMedicine
About Cleveland ClinicLocatedinCleveland,Ohio,ClevelandClinicisanonprofit,multispecialtyacademicmedicalcenterthatintegratesclinicalandhospitalcarewithresearchandeducation.Foundedin1921byfourrenownedphysicianswithavisionofprovidingoutstandingpatientcarebasedupontheprinciplesofcooperation,compassionandinnovation,itisthesecondlargestgrouppracticeintheworldwith2,000physiciansandscientistspracticingandresearchinginmorethan120medicalspecialitieswithmorethan1,300beds.InadditiontothemainhospitallocatednearCleveland’shistoricUniversityCircle,theClevelandClinicoperatesnineregionalhospitals,achildren’shospital,and17familyhealthcentersinOhioaswellashospitalsinFlorida,LasVegas,Canada,andDubai,employingmorethan40,000individualsandprovidingglobalworld-classmedicalcare.Lastyearalone,3.7millionpatientsfromover80countriesandall50statesreceivedtheircareatClevelandClinic.
Themainhospitalcampus,locatedneardowntownCleveland,occupies180acresand50buildings.Itincludesahospital,anoutpatientclinic,achildren’shospital,cancerinstitute,eyeinstitute,researchinstitute,amedicalschoolandsupportinglabsandfacilities.Tolearnmore,visittheClevelandClinichomepage.
FacilitiesResearchandClinicalLaboratoriesoccupyover2500squarefeetofworkspacewithstate-of-the-artinstrumentsandfacilitiesforadvancedresearchinthepathophysiologyofmaleandfemalereproductivedysfunction.Instrumentsinclude:computerassistedsemenanalyzers,luminometerforoxidativestressmeasurements,equipmentforwesternblot,cultureroomequippedwithasterilehood,severalincubators,microscopes,aNarishigeandRImicromanipulatorfittedonaninvertedphase-contrastmicroscope,spectrophotometers,ELISAplatereader,centrifuges,liquidnitrogenstoragetanks,programmablefreezers,andcoldroom.ThecenterhasreadyaccesstooveradozenspecializedcorelaboratorieswithintheClevelandClinicResearchInstitute.Theseinclude:molecularbiotechnology,flowcytometry,geneexpression,andtransgenic/knockoutfacilities.Clickhereformoreinformationonthesecorelaboratories.
Takeavirtualtourofthecenter’slabs.
Theofficespaceforfellowsisequippedwithover2dozencomputerswithlaserprinters,scanners,copiers,andallthenecessarysoftwareprograms.AllcomputersinthecenterareconnectedtotheClevelandClinic’snetworksystemthatprovidesdirectaccesstomostonlinejournalsrelatedtothefieldofmedicine,urology,reproductivemedicine,andrology,etc.Alargecollectionofscientificjournals,electronicjournals/books,andotherdatabasesarealsoavailablethroughournewlymodernizedClevelandClinicAlumniLibrary.AteamofstatisticiansworkingintheDepartmentofQuantitativeHealthSciencesprovideresearchsupporttotheFellows,andtheArtsandGraphicsDepartmentsupportsthepreparationofresearchpostersandlectureslidesforpresentationsatnationalmeetings.
Center for Reproductive MedicineTheClevelandClinicCenterforReproductiveMedicineisajointprogramoftheGlickmanUrological&KidneyInstituteandtheObstetrics-Gynecology&Women’sHealthInstitute.Establishedin1993,theCenterisdedicatedtoitsmissionofresearch,physicianeducationandpatientcare.
TheCenterforReproductiveMedicinehasaninternationalreputationforexcellenceininnovativeresearchinhumanfertilityandisdedicatedtodisseminatingitsresults.ResearchpapersfromtheCenter’sfacultyareselectedregularlyforpublicationindistinguishedspecialtymedicaljournals.
TheCenter’swebsitehasbeenranked#1forresearchinreproductivemedicineandandrologysince2001bythetopfiveinternationalsearchengines,includingGoogleandAltavista.Morethan150physiciansandscientistsfromover40countrieshavereceivedtheirtrainingattheCenterforReproductiveMedicineinthepast18years.Also,morethan100pre-medandmedicalstudentshaveparticipatedinresearchinternshipswiththecenter.
ResearchFellowship6|ClevelandClinicCenterforReproductiveMedicine
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