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CCA MUTATIONS

Cholangiocarcinoma Foundation - cholangiocarcinoma.org

Image provided by Foundation Medicine, Inc., Cambridge, MA, USA http://journals.sagepub.com/doi/full/10.1177/1756283X17698090

Substitution

Indel

Copy Number

Rearrangement

Splice

KEY

Figure 1. Long tail plot of the distribution of genomic alterations in 1682 cases of ICC(Provided by Foundation Medicine, Inc., Cambridge, MA, USA).

© 2017 by SAGE Publications

Long tail plot of the distribution of genomic alterations in 1682 cases of ICC

30

25

20

15

10

5

0

TP53

CD

KN2A

KRA

SC

DN

2BA

RID

1AID

H!

BAP1

FGFR

2PB

RM1

PIK3

CA

MC

L1BR

AF

MYC

SMA

D4

MD

M2

ATM

NRA

SER

BB2

PTEN

IDH

2ST

K11

CC

ND

1A

PCM

LL2

FGF1

9FB

XW7

MD

M4

FGF4

BRC

A2

FGF3

FRS2

LRP1

BRB

1EG

FRTE

RTA

RID

2C

DK6

MET

NF1

AKT

3PI

K3C

2BC

CN

E1IK

BKE

MYS

T3D

NM

T3A

ERBB

3SF

3B1

TSC

1BC

OR

GN

AS

PERC

ENT

OF

PATI

ENTS

Figure 2. Long tail plot of the distribution of genomic alterations in 251 cases of ECC(Provided by Foundation Medicine, Inc., Cambridge, MA, USA).

© 2017 by SAGE Publications

Long tail plot of the distribution of genomic alterations in 251 cases of ECC

TP53

KRA

SC

DKN

2AC

DKN

2BSM

AD

4A

RID

1AER

BB2

PBRM

1C

CN

E1A

PCAT

MM

YCM

DM

2BR

AF

PTEN

BAP1

PIK3

CA

BRC

A2

FRS2

STK1

1G

ATA

6SF

381

IDH

1C

CN

D1

NF1

ARI

D2

RBM

10KD

M6A

NRA

STE

RTA

KT2

FGFR

2FG

F4FG

F3FG

F19

FBXW

7M

CL1

PIK3

C2B

MLL

2BC

ORL

1EG

FRLR

P1B

RIC

TOR

RNF4

3G

NA

STE

T2C

DK4 AXL

BRC

A1

NTR

K1

50

40

30

20

10

0

PERC

ENT

OF

PATI

ENTS