cme 2014 presentation

Future of the Medicine Cellular Medicine

Dr. Pradeep MahajanStem Cells Transplant Expert | Founder @ StemRx Bioscience Solutions Pvt, ltd. India

Life Expectancy. Future of Medicine – Next 100 years. Cellular Medicine – What’s so new? Drug Discovery in a dish. Organ Shop- fiction or reality?. A paradigm shift from traditional medicine to

cellular medicine – New dimensions . Cellular medicine and Therapeutic

Applications.

Talk Outline

Limitations of proven therapies No longer medical science has remained the

domain of only physicians, clinicians . Researchers in Regenerative Medicine

developing new protocols.

Gradual increase in Life expectancy

Introduction

Antibiotics, vaccines

SanitizationSuperstitious

Visualize the future of medicine in next 100 years

Future of medicine – next 100 years

Tele-medicine-• Internets Skype• Virtual consultations• Satellite – Robotic/ diagnostics•Google Mirror –Using Sensor technology with hardware & Software with internet•Holographic consultations with doctors

Digital Medicine-• I phones• Digitalization of histopathology• Brain computed chips• Artificial augmented limbs

Robotic Medicine-• Robotic Minimal invasive surgeries• Robotic tele assisted surgeries• Intelligent autonomous robotic surgeries with high speed & resolution MRI• I-knives with cancer therapies

Cancer- No more Mystery- Cancer gene Chemotherapy, Radiotherapy- Non specific

Patient specific , organ specific & disease specific personalized therapy• DNA chips• Nanoparticles – Magnetic/ Antibody

Cell Based Therapies• DC cells• T cells• NK cells

Genomic & Molecular Medicine-Gene is software Protein is hardware• Genetic engineering• Proteomics

• Nanotechnology- applications in•Cancer •Metabolic and •Genetic diseases

DNA / Gene is software protein is hardware

Man made Macro Machines

Nature made Nano Machines

Electric Fence Membrane

Transporters Hb

Digital database Nucleus

Bulldozers Proteosomes

Control centers Centrosomes

Chain couplers Ligase

Internet Nodes Neural System

“ About 1000 years ago, humans domesticated plants and animals….now its time to domesticate molecules”

Cellular Medicine coupled with digital medicine, telemedicine , nanomedicine can create wonders………

-Use of miraculous stem cells

-Advanced applications of stem cells

-Curative medicine

The first major revolution……..Its not the science fiction – It’s the stem cells research……

“ Hope and dreams for stem cells – we live in a time where the word impossible and unsolvable are no longer part scientific communities vocabulary. Each day we move closer to trials that will not just minimize the symptoms of diseases and injuries but eliminate them”

- Christopher Reeve

( Superman )

In fact he introduced stem cells research legacy to the world

Imagine……….

Research

Dolly the Sheep

Ethical & Social Issues

ESC- Embryonic Stem Cells

Invention of IPSC’s – Reprogramming of somatic skin cells,

Embryonic Transcription factors : Oct4, Sox2, KLF4, Cmyc

Developing all 220 types of cells.

“ Its not a science fiction . Its stem cells research led to never before in the history of medical science. Such a gift received to humans – Stem Cells- which can regenerate the cells to tissue to the organs”

Science of personalized organ specific medicine

Somatic cells/ Stem Cells

Transplanted back

iPSC/ Stem Cells

Culture

Differentiation

Drug Discovery in a dish

Dustan & Haffman ( 1960 )

Biodegradable scaffolds (2012)

Body Organ Shop

Future is organ development in a dish!!!!

Breakthrough achievement in organ transplant……

The technologies for organ development 1. 3D printing technology2. Scanner technology3.Cadaver organs like liver, kidney by

washing out cellular material

Cellular Medicine – What’s so new

Cells Scaffolds

Regenerative Medicine

Grafts

Bioengineering and repair of the damaged tissue with the help of cells in scaffolds

Organ Shop

Stem cells and biological products as drugs

- PRP kits- Specialized cells developed in Petri dishes- Different cell lines like cardio-myocytes, osteocytes, chondrocytes etc…

Bone Marrow Aspiration

Adipose Tissue Aspiration

Harvesting of stem cells

Injecting Cells inside the body

Stem Cells to differentiate and form different tissues and organs

How does it work ?

Cellular Medicine & Robotics

Cellular Medicine & Genomics

Cellular Medicine & Proteomics

Healing Force Of The Future

VSEL’s T – Regulatory cells EPC NK,T, DC T-Regulatory Cytokines- Micro-medicineAnd many more…………

Advances in the new cell lines….

Therapeutic Applications of Cellular Medicine………

Applications of Stem Cells….

More than 4000 patients treated One of the leader in therapeutic

applications of stem cells Full equipped facility for sample

processing, research and quality control Trained laboratory and clinical personnel Conducting PhD/ M.Sc courses in Stem

cells in collaboration with ITM Currently working on several research

projects covering most of the clinical disorder in human being

StemRx in cellular medicine

T-regulatory cell Therapy for immune modulation .

Applications of Vsel cell. Cytokines and growth hormones for

oral and injectable therapies. DC T-cell and NK Cell therapies .

StemRx in Future

“ So many of our dreams at first looked impossible …then improvable …but when we summon the will , they soon become inevitable..”

Thank You…….