constructing s.t.e.a.m.: a physicsian scientist’s perspective

Constructing S.T.E.A.M.Constructing S.T.E.A.M.: : aa PHYSICSian scientist’s perspective PHYSICSian scientist’s perspectiveSherry-Ann Brown, MD, PhD@drbrowncares, drbrowncares@gmail.com

www.myschoolhouse.com

S.T.E.M.

@drbrowncaresdrbrowncares@gmail.com

S.T.E. M.

S.T.E.A.M.www.myschoolhouse.com

Star Trek: The Next Generation sixth season episode "Second Chances"

The Cerebellum

• Latin, little brain

• Constitutes only 10% of the total volume of the brain, but contains more than half of all its neurons

• Coordinates posture, gaze, speech, handwriting, and other motor functions

The Cerebellum, Principles of Neural Science. 2000 McGraw Hill.

ATAXIAATAXIAnn. . GreekGreek. Loss of motor coordination.. Loss of motor coordination.

Climbing Fiber Stimulus Depolarization throughout PN Extracellular Calcium entry into cell!

Parallel Fiber Stimulus IP3 Production Calcium mobilization from ER!ER = endoplasmic reticulum

Cerebellar Purkinje Neuron Cerebellar Purkinje Neuron (PN)(PN)

Hernjak et al, Biophysical Journal 2005

Parallel fiber stimulus

Climbing fiber stimulus

Calcium Pathways In The Cell

Coincident Coincident IncidentIncident

Aim 1:3D Model

Purkinje neuronReconstructed Experimental 3D Geometry of

Purkinje Cell Dendrite Branchlet

Aim 1:3D Model

PIP2 Diffusion in the spine membrane

SIX Spines - Simulation Max

Aim 1:3D Model

Aim 2:Electric Model

Preserved electronic PATH in red, spine of interest in blue

Neuronal morphology

The Dendrite as an Electrical Circuit

Simplification of Purkinje Neuronal Morphology

Miyasho et al., Brain Research, 2001@drbrowncares

drbrowncares@gmail.com

Comparison of Electrical Activity in the Full and Reduced Models - soma

0 500Time (ms)

tial (

0 500Time (ms)

tial (

Full model Reduced model

Hernjak et al, Biophysical Journal 2005@drbrowncares

Aim 3:Ataxia Model

Aim 1:3D Model

Aim 2:Electric Model

Impact

CitationsTextbooks (11) + Journal articles (33)

Coincident IncidentHow Will I Dance?

Just One More Step

My Thesis CommitteeMy Thesis CommitteeCCAM, MD/PhD ProgramCCAM, MD/PhD Program

University of Connecticut Health CenterUniversity of Connecticut Health CenterNIHNIH

Primary Investigator:Primary Investigator:Dr. Leslie M. Loew Dr. Ion Moraru

Dr. James Schaff

Dr. Ann Cowan

Dr. Raquell Holmes

Dr. James WatrasDr. James WatrasMr. Frank MorganMr. Frank Morgan

Ed & ElenaEd & Elena

Karen, Donna, Karen, Donna, DebbieDebbie

Anu, Fei, Li Ye; Boris, Igor, Pavel

Sofya, Jon, Stacy

Dr. Art HandDr. Art HandDr. Bill LyttonDr. Bill Lytton

Dr. Marja HurleyDr. Marja Hurley

Stepping In & Out

Sherry-Ann Brown, MD, PhDCI Planning Meeting 2015

Thesis reception: S.T.E.A.M. poetry collection poster, art & photography@drbrowncares

Towards Patient Avatars

Shear & Tensile Stress Injury to Arteries (and Nerves)

Who I Am

S.T.E.A.M. in Action

Sherry-Ann Brown, MD, PhD@drbrowncares, drbrowncares@gmail.com

Constructing S.T.E.A.M.Constructing S.T.E.A.M.: : aa PHYSICSian scientist’s perspective PHYSICSian scientist’s perspective

Ohm’s Law & Blood Circulation

Ohms Law Darcy’s Law V = I x R BP = Q x VR

"The heart is the only organ of all organs that can not endure injury. This is expected because when the main power source is destroyed, no additional force can be brought by the organs that depend on it" (Aristotle - 384 BC).

www.slideshare.net, http://www.scielo.br/scielo.php?pid=S0102-76382010000100006&script=sci_arttext&tlng=enwww.slideshare.net, http://www.scielo.br/scielo.php?pid=S0102-76382010000100006&script=sci_arttext&tlng=en @drbrowncaresdrbrowncares@gmail.com

• In a noncompressible fluid system, flow is the same at any given point

• Flow = area x velocity

• area x velocity = area x velocity

• F V r∝ ⋅ 2

cm³ ► cm² cmx

Conservation of Mass Principle

Compliments of Dr. Hector Michelena, Mayo Clinic

Turbulent Blood Flow

www.cvphysiology.com

F V r∝ ⋅ 2

area x velocity

Heart Murmurs

Normal Narrow

www.cvphysiology.comwww.cvphysiology.com

Heart Murmurs

http://www.boxerbreedcouncil.co.uk/as.htmhttp://www.boxerbreedcouncil.co.uk/as.htm

Sherry-Ann Brown, MD, PhD@drbrowncares, drbrowncares@gmail.com

Constructing S.T.E.A.M.Constructing S.T.E.A.M.: : aa PHYSICSian scientist’s perspective PHYSICSian scientist’s perspective

constructing s.t.e.a.m.: a physicsian scientist’s perspective

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